ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptic vesicle maturation (GO:0016188)	8.08669109
2	synaptic vesicle docking involved in exocytosis (GO:0016081)	7.69040508
3	regulation of short-term neuronal synaptic plasticity (GO:0048172)	7.10301776
4	glutamate secretion (GO:0014047)	7.07539327
5	synaptic vesicle exocytosis (GO:0016079)	6.24058846
6	regulation of synaptic vesicle exocytosis (GO:2000300)	6.13037915
7	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	5.99391816
8	sodium ion export (GO:0071436)	5.83118909
9	cellular potassium ion homeostasis (GO:0030007)	5.76494095
10	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	5.58268836
11	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	5.55850166
12	neurotransmitter secretion (GO:0007269)	5.48009136
13	regulation of synaptic vesicle transport (GO:1902803)	5.42120808
14	gamma-aminobutyric acid signaling pathway (GO:0007214)	5.25945719
15	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.78975572
16	regulation of neuronal synaptic plasticity (GO:0048168)	4.77509268
17	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	4.69610268
18	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.67355012
19	locomotory exploration behavior (GO:0035641)	4.66421397
20	vocalization behavior (GO:0071625)	4.65288773
21	neuronal action potential propagation (GO:0019227)	4.65285110
22	neurotransmitter transport (GO:0006836)	4.64258712
23	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	4.50428870
24	protein localization to synapse (GO:0035418)	4.50064177
25	cerebellar granule cell differentiation (GO:0021707)	4.46460313
26	synaptic transmission, glutamatergic (GO:0035249)	4.46078951
27	neuron-neuron synaptic transmission (GO:0007270)	4.38559096
28	potassium ion import (GO:0010107)	4.37955357
29	proline transport (GO:0015824)	4.37877296
30	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	4.37178757
31	regulation of long-term neuronal synaptic plasticity (GO:0048169)	4.25989186
32	gamma-aminobutyric acid transport (GO:0015812)	4.25516580
33	positive regulation of synapse maturation (GO:0090129)	4.23701396
34	response to histamine (GO:0034776)	4.19054279
35	exploration behavior (GO:0035640)	4.17512335
36	regulation of neurotransmitter levels (GO:0001505)	4.15127627
37	regulation of glutamate receptor signaling pathway (GO:1900449)	4.14646031
38	postsynaptic membrane organization (GO:0001941)	4.10380064
39	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	4.08013742
40	regulation of neurotransmitter secretion (GO:0046928)	4.07781597
41	neuron cell-cell adhesion (GO:0007158)	3.98974960
42	cochlea development (GO:0090102)	3.92911093
43	L-amino acid import (GO:0043092)	3.91232357
44	mating behavior (GO:0007617)	3.90783879
45	regulation of excitatory postsynaptic membrane potential (GO:0060079)	3.90694310
46	neuronal ion channel clustering (GO:0045161)	3.88568131
47	synaptic vesicle endocytosis (GO:0048488)	3.88025512
48	cellular sodium ion homeostasis (GO:0006883)	3.87369268
49	glutamate receptor signaling pathway (GO:0007215)	3.82575970
50	dendritic spine morphogenesis (GO:0060997)	3.81963407
51	membrane depolarization during action potential (GO:0086010)	3.81269440
52	potassium ion homeostasis (GO:0055075)	3.79388015
53	regulation of synapse structural plasticity (GO:0051823)	3.78324711
54	cell communication by electrical coupling (GO:0010644)	3.77748231
55	neurotransmitter-gated ion channel clustering (GO:0072578)	3.77423382
56	presynaptic membrane organization (GO:0097090)	3.75545048
57	positive regulation of membrane potential (GO:0045838)	3.74968318
58	regulation of neurotransmitter transport (GO:0051588)	3.74322068
59	axon ensheathment in central nervous system (GO:0032291)	3.73209545
60	central nervous system myelination (GO:0022010)	3.73209545
61	regulation of voltage-gated calcium channel activity (GO:1901385)	3.71429548
62	regulation of vesicle fusion (GO:0031338)	3.70650510
63	regulation of synaptic plasticity (GO:0048167)	3.68429893
64	innervation (GO:0060384)	3.67382227
65	positive regulation of neurotransmitter secretion (GO:0001956)	3.65678043
66	positive regulation of neurotransmitter transport (GO:0051590)	3.63238347
67	layer formation in cerebral cortex (GO:0021819)	3.61582379
68	regulation of postsynaptic membrane potential (GO:0060078)	3.60249925
69	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.54425720
70	transmission of nerve impulse (GO:0019226)	3.53500493
71	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.49910650
72	cerebellar Purkinje cell differentiation (GO:0021702)	3.49586229
73	positive regulation of dendritic spine development (GO:0060999)	3.49367257
74	membrane depolarization (GO:0051899)	3.48294744
75	amino acid import (GO:0043090)	3.47280688
76	neuromuscular process controlling balance (GO:0050885)	3.43980348
77	presynaptic membrane assembly (GO:0097105)	3.42960214
78	neuromuscular synaptic transmission (GO:0007274)	3.40581396
79	regulation of synapse maturation (GO:0090128)	3.36721362
80	synaptic transmission (GO:0007268)	3.30993904
81	long-term memory (GO:0007616)	3.22781627
82	regulation of synaptic transmission, glutamatergic (GO:0051966)	3.21925458
83	prepulse inhibition (GO:0060134)	3.21774956
84	auditory behavior (GO:0031223)	3.17413052
85	regulation of synaptic transmission (GO:0050804)	3.14863064
86	cell communication involved in cardiac conduction (GO:0086065)	3.13970939
87	regulation of ARF protein signal transduction (GO:0032012)	3.12589741
88	detection of calcium ion (GO:0005513)	3.10428180
89	establishment of synaptic vesicle localization (GO:0097480)	3.08734974
90	synaptic vesicle transport (GO:0048489)	3.08734974
91	long-term synaptic potentiation (GO:0060291)	3.08598906
92	behavioral response to cocaine (GO:0048148)	3.05975164
93	adult walking behavior (GO:0007628)	3.04897736
94	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.03291146
95	regulation of catecholamine metabolic process (GO:0042069)	3.03191532
96	regulation of dopamine metabolic process (GO:0042053)	3.03191532
97	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.02683501
98	behavioral defense response (GO:0002209)	3.02479417
99	behavioral fear response (GO:0001662)	3.02479417
100	negative regulation of dendrite morphogenesis (GO:0050774)	3.01989107

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.87433332
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.51071013
3	REST_21632747_ChIP-Seq_MESCs_Mouse	3.38199767
4	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	3.14415264
5	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	3.07641940
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	3.07164642
7	DROSHA_22980978_ChIP-Seq_HELA_Human	2.92923370
8	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.74844038
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.73223815
10	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	2.68674120
11	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.67849103
12	RARB_27405468_Chip-Seq_BRAIN_Mouse	2.60702472
13	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.59139864
14	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.59139864
15	MTF2_20144788_ChIP-Seq_MESCs_Mouse	2.56092292
16	GBX2_23144817_ChIP-Seq_PC3_Human	2.55347341
17	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.52902755
18	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.47705193
19	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.45379568
20	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.43438253
21	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	2.36290544
22	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.34275943
23	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.30521963
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.29285132
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.28915081
26	AR_21572438_ChIP-Seq_LNCaP_Human	2.03364483
27	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.95145715
28	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.91142962
29	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.83113928
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81873646
31	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.81743726
32	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.80482538
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.62409843
34	RNF2_27304074_Chip-Seq_NSC_Mouse	1.54088184
35	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.51164028
36	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.49280751
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.46592683
38	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.40358984
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.38080002
40	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.37432073
41	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.37215779
42	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.35453238
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34962097
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30040064
45	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.28414711
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27601341
47	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.26210017
48	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.25389400
49	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23006870
50	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.17051677
51	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.14959280
52	KDM2B_26808549_Chip-Seq_K562_Human	1.14732467
53	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.12568612
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11068744
55	AR_19668381_ChIP-Seq_PC3_Human	1.09947970
56	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09022523
57	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.06232422
58	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.05077486
59	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.04999187
60	CTCF_27219007_Chip-Seq_Bcells_Human	1.02962365
61	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.02640741
62	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.01262089
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.99794165
64	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	0.99463749
65	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.97435337
66	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.97262259
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.95175103
68	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.95039126
69	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.91650394
70	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.91625551
71	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91615257
72	TCF4_23295773_ChIP-Seq_U87_Human	0.91130575
73	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90163053
74	STAT3_23295773_ChIP-Seq_U87_Human	0.89198308
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88961606
76	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.88320670
77	P300_19829295_ChIP-Seq_ESCs_Human	0.87907961
78	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.87539663
79	IGF1R_20145208_ChIP-Seq_DFB_Human	0.86882972
80	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.86483778
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.85282121
82	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.85127927
83	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.84284063
84	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.84190777
85	AR_25329375_ChIP-Seq_VCAP_Human	0.83926975
86	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.81511981
87	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.80927092
88	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79484996
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.78037325
90	OCT4_19829295_ChIP-Seq_ESCs_Human	0.77192682
91	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.77034580
92	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.75395366
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.75234424
94	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.75161515
95	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.74549489
96	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.73326739
97	KDM2B_26808549_Chip-Seq_REH_Human	0.73259270
98	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.72898147
99	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.72631041
100	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.72123177

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004859_abnormal_synaptic_plasticity	6.02415137
2	MP0003880_abnormal_central_pattern	5.04779606
3	MP0003635_abnormal_synaptic_transmissio	4.26736186
4	MP0005423_abnormal_somatic_nervous	4.18374090
5	MP0004270_analgesia	4.06800212
6	MP0002064_seizures	3.81015871
7	MP0009745_abnormal_behavioral_response	3.69682319
8	MP0009046_muscle_twitch	3.56915376
9	MP0002063_abnormal_learning/memory/cond	3.30796359
10	MP0002272_abnormal_nervous_system	3.08443144
11	MP0002572_abnormal_emotion/affect_behav	2.93443564
12	MP0001486_abnormal_startle_reflex	2.86658129
13	MP0001501_abnormal_sleep_pattern	2.83296020
14	MP0001968_abnormal_touch/_nociception	2.79078392
15	MP0002734_abnormal_mechanical_nocicepti	2.71859807
16	MP0008569_lethality_at_weaning	2.40888477
17	MP0002735_abnormal_chemical_nociception	2.31444364
18	MP0003879_abnormal_hair_cell	2.21390621
19	MP0002736_abnormal_nociception_after	2.14363226
20	MP0003329_amyloid_beta_deposits	2.09927511
21	MP0001970_abnormal_pain_threshold	2.04841105
22	MP0002733_abnormal_thermal_nociception	2.04563605
23	MP0002067_abnormal_sensory_capabilities	2.01084632
24	MP0001440_abnormal_grooming_behavior	1.93343374
25	MP0002557_abnormal_social/conspecific_i	1.80452994
26	MP0006276_abnormal_autonomic_nervous	1.76312761
27	MP0001905_abnormal_dopamine_level	1.71947300
28	MP0000778_abnormal_nervous_system	1.69053757
29	MP0005646_abnormal_pituitary_gland	1.67270617
30	MP0003787_abnormal_imprinting	1.65768868
31	MP0004811_abnormal_neuron_physiology	1.65303342
32	MP0004924_abnormal_behavior	1.59699776
33	MP0005386_behavior/neurological_phenoty	1.59699776
34	MP0002184_abnormal_innervation	1.59257638
35	MP0002066_abnormal_motor_capabilities/c	1.55128633
36	MP0002822_catalepsy	1.51118413
37	MP0004742_abnormal_vestibular_system	1.48780180
38	MP0002882_abnormal_neuron_morphology	1.46621506
39	MP0003633_abnormal_nervous_system	1.46485438
40	MP0000955_abnormal_spinal_cord	1.46078472
41	MP0003122_maternal_imprinting	1.41022256
42	MP0003690_abnormal_glial_cell	1.34609950
43	MP0003123_paternal_imprinting	1.33395397
44	MP0001502_abnormal_circadian_rhythm	1.29680372
45	MP0003631_nervous_system_phenotype	1.28591952
46	MP0009780_abnormal_chondrocyte_physiolo	1.26281530
47	MP0002229_neurodegeneration	1.25476589
48	MP0001177_atelectasis	1.22744726
49	MP0004885_abnormal_endolymph	1.21193970
50	MP0000920_abnormal_myelination	1.18794279
51	MP0000569_abnormal_digit_pigmentation	1.18042133
52	MP0010386_abnormal_urinary_bladder	1.17740394
53	MP0008877_abnormal_DNA_methylation	1.13302697
54	MP0001963_abnormal_hearing_physiology	1.12462337
55	MP0008872_abnormal_physiological_respon	1.10922809
56	MP0002909_abnormal_adrenal_gland	1.09881529
57	MP0001984_abnormal_olfaction	1.09054091
58	MP0002152_abnormal_brain_morphology	1.07627043
59	MP0008874_decreased_physiological_sensi	1.07294073
60	MP0001529_abnormal_vocalization	0.99802806
61	MP0002638_abnormal_pupillary_reflex	0.99210214
62	MP0004147_increased_porphyrin_level	0.99169496
63	MP0005551_abnormal_eye_electrophysiolog	0.97600694
64	MP0003634_abnormal_glial_cell	0.94939566
65	MP0003632_abnormal_nervous_system	0.94435488
66	MP0004510_myositis	0.93389039
67	MP0000604_amyloidosis	0.91150647
68	MP0004142_abnormal_muscle_tone	0.87821378
69	MP0002069_abnormal_eating/drinking_beha	0.84814224
70	MP0001485_abnormal_pinna_reflex	0.84439159
71	MP0001348_abnormal_lacrimal_gland	0.82885443
72	MP0004130_abnormal_muscle_cell	0.82277956
73	MP0001188_hyperpigmentation	0.79607132
74	MP0002752_abnormal_somatic_nervous	0.76599371
75	MP0000026_abnormal_inner_ear	0.71887771
76	MP0004043_abnormal_pH_regulation	0.71056845
77	MP0005645_abnormal_hypothalamus_physiol	0.68439871
78	MP0005535_abnormal_body_temperature	0.68068282
79	MP0003283_abnormal_digestive_organ	0.66320506
80	MP0005167_abnormal_blood-brain_barrier	0.63926694
81	MP0003137_abnormal_impulse_conducting	0.61423787
82	MP0004085_abnormal_heartbeat	0.61177454
83	MP0003121_genomic_imprinting	0.58919311
84	MP0002089_abnormal_postnatal_growth/wei	0.58533775
85	MP0001664_abnormal_digestion	0.57953598
86	MP0010769_abnormal_survival	0.56536628
87	MP0005187_abnormal_penis_morphology	0.55827629
88	MP0001986_abnormal_taste_sensitivity	0.54418532
89	MP0010768_mortality/aging	0.53615695
90	MP0000631_abnormal_neuroendocrine_gland	0.53383690
91	MP0010770_preweaning_lethality	0.52966460
92	MP0002082_postnatal_lethality	0.52966460
93	MP0003956_abnormal_body_size	0.52104650
94	MP0004484_altered_response_of	0.51464440
95	MP0003861_abnormal_nervous_system	0.51338256
96	MP0000534_abnormal_ureter_morphology	0.50806733
97	MP0000579_abnormal_nail_morphology	0.50313426
98	MP0003075_altered_response_to	0.50136330
99	MP0002090_abnormal_vision	0.49792486
100	MP0000566_synostosis	0.47453573

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	8.36050641
2	Focal motor seizures (HP:0011153)	7.72325913
3	Atonic seizures (HP:0010819)	6.52082354
4	Febrile seizures (HP:0002373)	6.28525196
5	Focal seizures (HP:0007359)	6.24889267
6	Limb dystonia (HP:0002451)	5.63082052
7	Epileptic encephalopathy (HP:0200134)	5.30800043
8	Supranuclear gaze palsy (HP:0000605)	5.12295700
9	Action tremor (HP:0002345)	4.96796341
10	Diplopia (HP:0000651)	4.94377819
11	Abnormality of binocular vision (HP:0011514)	4.94377819
12	Absence seizures (HP:0002121)	4.78038339
13	Generalized tonic-clonic seizures (HP:0002069)	4.62519812
14	Dialeptic seizures (HP:0011146)	4.41270695
15	Postural instability (HP:0002172)	4.19654569
16	Progressive cerebellar ataxia (HP:0002073)	4.13233734
17	Mutism (HP:0002300)	4.13126412
18	Neurofibrillary tangles (HP:0002185)	3.79640967
19	Visual hallucinations (HP:0002367)	3.68874363
20	Torticollis (HP:0000473)	3.54841324
21	Spastic gait (HP:0002064)	3.53611979
22	Abnormal eating behavior (HP:0100738)	3.51471951
23	Akinesia (HP:0002304)	3.43670455
24	Ankle clonus (HP:0011448)	3.39128206
25	Status epilepticus (HP:0002133)	3.27218767
26	Papilledema (HP:0001085)	3.25502042
27	Cerebral inclusion bodies (HP:0100314)	3.24069752
28	Bradykinesia (HP:0002067)	3.21241581
29	Urinary bladder sphincter dysfunction (HP:0002839)	3.11067810
30	Morphological abnormality of the pyramidal tract (HP:0002062)	3.00439149
31	Impaired vibration sensation in the lower limbs (HP:0002166)	2.98733804
32	Truncal ataxia (HP:0002078)	2.97578520
33	Hemiplegia (HP:0002301)	2.94368990
34	Focal dystonia (HP:0004373)	2.93206922
35	Neuronal loss in central nervous system (HP:0002529)	2.91521027
36	Rigidity (HP:0002063)	2.90910130
37	Anxiety (HP:0000739)	2.85247699
38	Dysmetria (HP:0001310)	2.81494520
39	Abnormality of the corticospinal tract (HP:0002492)	2.75597716
40	Craniofacial dystonia (HP:0012179)	2.74405913
41	Epileptiform EEG discharges (HP:0011182)	2.72931814
42	Obstructive sleep apnea (HP:0002870)	2.69160623
43	Poor eye contact (HP:0000817)	2.68184201
44	Hyperventilation (HP:0002883)	2.66245247
45	Polyphagia (HP:0002591)	2.60332867
46	Annular pancreas (HP:0001734)	2.58872464
47	Urinary urgency (HP:0000012)	2.54402741
48	Spastic tetraparesis (HP:0001285)	2.53404601
49	Depression (HP:0000716)	2.51297030
50	Amblyopia (HP:0000646)	2.49308253
51	Drooling (HP:0002307)	2.44990764
52	Intention tremor (HP:0002080)	2.44212153
53	Cerebral hypomyelination (HP:0006808)	2.42770848
54	Impaired smooth pursuit (HP:0007772)	2.38682041
55	EEG with generalized epileptiform discharges (HP:0011198)	2.37634383
56	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.32847015
57	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.32847015
58	Dysdiadochokinesis (HP:0002075)	2.31742337
59	Hemiparesis (HP:0001269)	2.31007024
60	Tetraplegia (HP:0002445)	2.30878357
61	Delusions (HP:0000746)	2.27813431
62	Ventricular fibrillation (HP:0001663)	2.27524135
63	Excessive salivation (HP:0003781)	2.26783868
64	Lower limb muscle weakness (HP:0007340)	2.26007461
65	Decreased central vision (HP:0007663)	2.25693666
66	Broad-based gait (HP:0002136)	2.25677633
67	Hypsarrhythmia (HP:0002521)	2.23836577
68	Impaired social interactions (HP:0000735)	2.22748962
69	Abnormal social behavior (HP:0012433)	2.22748962
70	Sleep apnea (HP:0010535)	2.22395652
71	Prolonged QT interval (HP:0001657)	2.20230658
72	Abnormality of the lower motor neuron (HP:0002366)	2.19124132
73	Gaze-evoked nystagmus (HP:0000640)	2.14758654
74	Amyotrophic lateral sclerosis (HP:0007354)	2.12401480
75	Stereotypic behavior (HP:0000733)	2.12083126
76	Rapidly progressive (HP:0003678)	2.05347924
77	Syncope (HP:0001279)	2.04196091
78	Abnormal EKG (HP:0003115)	2.03419201
79	Choreoathetosis (HP:0001266)	2.03332675
80	Apathy (HP:0000741)	2.00960613
81	Impaired vibratory sensation (HP:0002495)	2.00504332
82	Abnormality of ocular smooth pursuit (HP:0000617)	1.96045018
83	Incomplete penetrance (HP:0003829)	1.94174146
84	Diminished movement (HP:0002374)	1.92766823
85	Diminished motivation (HP:0000745)	1.90986821
86	Genetic anticipation (HP:0003743)	1.86505958
87	Abnormality of saccadic eye movements (HP:0000570)	1.83321837
88	Protruding tongue (HP:0010808)	1.83317891
89	Aplasia involving bones of the extremities (HP:0009825)	1.83235559
90	Aplasia involving bones of the upper limbs (HP:0009823)	1.83235559
91	Aplasia of the phalanges of the hand (HP:0009802)	1.83235559
92	Peripheral hypomyelination (HP:0007182)	1.79218088
93	Clonus (HP:0002169)	1.79013836
94	Generalized myoclonic seizures (HP:0002123)	1.75818234
95	Turricephaly (HP:0000262)	1.74964442
96	Inability to walk (HP:0002540)	1.73144141
97	Dyskinesia (HP:0100660)	1.71975884
98	Bronchomalacia (HP:0002780)	1.69871192
99	Abnormality of macular pigmentation (HP:0008002)	1.67493608
100	CNS hypomyelination (HP:0003429)	1.66807392

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	4.76701638
2	MARK1	4.40938688
3	NTRK3	3.53409604
4	DAPK2	3.32163407
5	PAK6	3.27853837
6	MAP3K9	3.06653795
7	CASK	2.81298522
8	NTRK1	2.61668684
9	NTRK2	2.40859437
10	UHMK1	2.33290781
11	LATS2	2.27652384
12	MINK1	2.21920924
13	CAMKK1	2.16795730
14	PINK1	1.86347159
15	MAPK13	1.83151671
16	INSRR	1.76755335
17	PRKD3	1.67281690
18	GRK5	1.65887548
19	CDK5	1.63865598
20	ARAF	1.63066635
21	PHKG2	1.59376114
22	PHKG1	1.59376114
23	PLK2	1.54924593
24	NEK6	1.50396871
25	RIPK4	1.49827387
26	PRKCG	1.42596996
27	KSR2	1.40963057
28	MAP3K4	1.34450892
29	CAMK1	1.30149753
30	CAMK2B	1.29770680
31	MAP2K7	1.23177088
32	CDK19	1.20468070
33	CAMKK2	1.19533216
34	TYRO3	1.18643688
35	CAMK2A	1.18597674
36	DYRK1A	1.11001912
37	DAPK1	1.10955193
38	SGK223	1.10511593
39	SGK494	1.10511593
40	MAP2K4	1.10087485
41	MAP3K12	1.08724980
42	CDK15	1.08590407
43	PNCK	1.08493278
44	MAP2K6	1.05481060
45	CDK18	1.05326112
46	STK38	1.02182676
47	OXSR1	1.02145161
48	CDK14	1.01077201
49	PRKCH	1.00342015
50	WNK1	1.00323428
51	CDK11A	0.98175315
52	CAMK1G	0.91825031
53	PAK3	0.89879418
54	STK11	0.85892487
55	SGK2	0.84077198
56	ICK	0.83923427
57	CSNK1G2	0.81932459
58	MAP3K11	0.81541289
59	BMPR2	0.81116334
60	CAMK1D	0.79794225
61	CAMK2G	0.77323335
62	MAPK12	0.77094811
63	MAPKAPK5	0.74510784
64	SIK2	0.74096745
65	MARK2	0.71338086
66	RIPK1	0.69687562
67	SGK1	0.69358174
68	CAMK4	0.65935311
69	LIMK1	0.64269201
70	MAP3K13	0.63674666
71	PKN1	0.62647793
72	PDK1	0.62582276
73	BRAF	0.58749721
74	MAP3K2	0.57709556
75	ALK	0.56526643
76	RET	0.55413869
77	SGK3	0.53582111
78	MAPK10	0.53078833
79	PRKCZ	0.52863472
80	DYRK2	0.52099080
81	RPS6KA3	0.51688155
82	CAMK2D	0.50910130
83	PDPK1	0.50475634
84	BRSK1	0.49081760
85	KSR1	0.44206134
86	PRKCE	0.41656425
87	PRKCA	0.39297921
88	PTK2B	0.38501432
89	FYN	0.36893748
90	PRKG2	0.35997209
91	CSNK1G3	0.35943401
92	TESK1	0.33573765
93	CSNK1D	0.33133396
94	CSNK1A1L	0.32521005
95	MAPK8	0.28905496
96	PRKACA	0.27723416
97	STK39	0.27602809
98	MAP3K1	0.27284515
99	PRKG1	0.26950858
100	FES	0.26419049

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	5.18762206
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.93517603
3	GABAergic synapse_Homo sapiens_hsa04727	3.13670691
4	Morphine addiction_Homo sapiens_hsa05032	3.07874753
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.92293067
6	Amphetamine addiction_Homo sapiens_hsa05031	2.90480385
7	Long-term potentiation_Homo sapiens_hsa04720	2.63202069
8	Circadian entrainment_Homo sapiens_hsa04713	2.62969372
9	Glutamatergic synapse_Homo sapiens_hsa04724	2.51008339
10	Insulin secretion_Homo sapiens_hsa04911	2.44109197
11	Cocaine addiction_Homo sapiens_hsa05030	2.36855557
12	Dopaminergic synapse_Homo sapiens_hsa04728	2.34950784
13	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.30685453
14	Gastric acid secretion_Homo sapiens_hsa04971	2.21154855
15	Cholinergic synapse_Homo sapiens_hsa04725	1.86405663
16	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.80713718
17	Salivary secretion_Homo sapiens_hsa04970	1.80213607
18	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.77093495
19	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.74903635
20	Taste transduction_Homo sapiens_hsa04742	1.72394552
21	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.66295676
22	Serotonergic synapse_Homo sapiens_hsa04726	1.53474538
23	Calcium signaling pathway_Homo sapiens_hsa04020	1.51459009
24	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.50854437
25	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.42682563
26	Long-term depression_Homo sapiens_hsa04730	1.36507193
27	cAMP signaling pathway_Homo sapiens_hsa04024	1.33811763
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.33507061
29	Olfactory transduction_Homo sapiens_hsa04740	1.25465203
30	Renin secretion_Homo sapiens_hsa04924	1.25199115
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.24509907
32	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.23879382
33	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.17640679
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.16804643
35	GnRH signaling pathway_Homo sapiens_hsa04912	1.11164698
36	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.06833541
37	Estrogen signaling pathway_Homo sapiens_hsa04915	1.06597034
38	Phototransduction_Homo sapiens_hsa04744	1.05988654
39	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.02713210
40	Type II diabetes mellitus_Homo sapiens_hsa04930	1.00728718
41	Gap junction_Homo sapiens_hsa04540	0.96275146
42	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.94797348
43	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.93502560
44	Pancreatic secretion_Homo sapiens_hsa04972	0.89884215
45	Oocyte meiosis_Homo sapiens_hsa04114	0.87790163
46	Bile secretion_Homo sapiens_hsa04976	0.87162848
47	ErbB signaling pathway_Homo sapiens_hsa04012	0.85570421
48	Melanogenesis_Homo sapiens_hsa04916	0.83424086
49	Glioma_Homo sapiens_hsa05214	0.82379001
50	Vibrio cholerae infection_Homo sapiens_hsa05110	0.80547137
51	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76912731
52	Axon guidance_Homo sapiens_hsa04360	0.74380027
53	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.73578975
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.73401771
55	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.69764051
56	VEGF signaling pathway_Homo sapiens_hsa04370	0.64878869
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.63077822
58	MAPK signaling pathway_Homo sapiens_hsa04010	0.62889506
59	Ras signaling pathway_Homo sapiens_hsa04014	0.57954547
60	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.53414665
61	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.53302923
62	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.53175897
63	Prion diseases_Homo sapiens_hsa05020	0.52494741
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52025507
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.49494503
66	Choline metabolism in cancer_Homo sapiens_hsa05231	0.49025816
67	Rap1 signaling pathway_Homo sapiens_hsa04015	0.47212565
68	Histidine metabolism_Homo sapiens_hsa00340	0.46208910
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.45083633
70	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.44634590
71	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.44139698
72	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.42319006
73	Circadian rhythm_Homo sapiens_hsa04710	0.42240581
74	Alcoholism_Homo sapiens_hsa05034	0.41476947
75	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.41229223
76	Alzheimers disease_Homo sapiens_hsa05010	0.39610515
77	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.38424032
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37203440
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36973567
80	Endocytosis_Homo sapiens_hsa04144	0.35340481
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35205608
82	Mineral absorption_Homo sapiens_hsa04978	0.33519776
83	Renal cell carcinoma_Homo sapiens_hsa05211	0.30051371
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.28390754
85	Butanoate metabolism_Homo sapiens_hsa00650	0.26744955
86	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.26448991
87	Wnt signaling pathway_Homo sapiens_hsa04310	0.26303555
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.24230850
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.23820259
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.23525876
91	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.21352054
92	mTOR signaling pathway_Homo sapiens_hsa04150	0.19892971
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.19433110
94	Parkinsons disease_Homo sapiens_hsa05012	0.19420668
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.18865454
96	AMPK signaling pathway_Homo sapiens_hsa04152	0.18626203
97	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.17679613
98	Oxidative phosphorylation_Homo sapiens_hsa00190	0.17008433
99	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.16518173
100	Insulin signaling pathway_Homo sapiens_hsa04910	0.16255504

PABPC1L2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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