PABPC1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)5.26852644
2behavioral response to nicotine (GO:0035095)5.07813082
3regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)4.91484640
4centriole replication (GO:0007099)4.86283861
5DNA replication checkpoint (GO:0000076)4.65037659
6regulation of meiosis I (GO:0060631)4.62601131
7regulation of double-strand break repair via homologous recombination (GO:0010569)4.55421548
8chromatin remodeling at centromere (GO:0031055)4.55099293
9sister chromatid segregation (GO:0000819)4.50701202
10rRNA methylation (GO:0031167)4.47596549
11protein localization to cilium (GO:0061512)4.41161009
12attachment of spindle microtubules to kinetochore (GO:0008608)4.31625823
13rRNA modification (GO:0000154)4.28518924
14somite rostral/caudal axis specification (GO:0032525)4.02884732
15behavioral response to ethanol (GO:0048149)4.01670271
16regulation of hypersensitivity (GO:0002883)3.93080090
17regulation of cilium movement (GO:0003352)3.88540642
18DNA catabolic process, exonucleolytic (GO:0000738)3.88463421
19negative regulation of interleukin-1 beta production (GO:0032691)3.82126289
20DNA double-strand break processing (GO:0000729)3.78584888
21protein K6-linked ubiquitination (GO:0085020)3.78050777
22regulation of translational termination (GO:0006449)3.77795640
23microtubule anchoring (GO:0034453)3.71115695
24CENP-A containing nucleosome assembly (GO:0034080)3.65569300
25mitochondrial DNA replication (GO:0006264)3.64683389
26monoubiquitinated protein deubiquitination (GO:0035520)3.62750079
27positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.57143701
28microtubule depolymerization (GO:0007019)3.50618778
29DNA deamination (GO:0045006)3.44850309
30neural tube formation (GO:0001841)3.43171168
31recombinational repair (GO:0000725)3.42292763
32double-strand break repair via homologous recombination (GO:0000724)3.39659668
33proteasome assembly (GO:0043248)3.38576807
34regulation of centriole replication (GO:0046599)3.37650438
35male meiosis (GO:0007140)3.34475398
36replication fork processing (GO:0031297)3.31619943
37negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.29513977
38otic vesicle formation (GO:0030916)3.23916528
39mitotic sister chromatid segregation (GO:0000070)3.22762393
40negative regulation of interleukin-1 production (GO:0032692)3.20241423
41histone exchange (GO:0043486)3.18539336
42negative regulation of cell cycle G2/M phase transition (GO:1902750)3.18370719
43microtubule polymerization or depolymerization (GO:0031109)3.16704745
44centriole assembly (GO:0098534)3.12354412
45positive regulation of mast cell activation involved in immune response (GO:0033008)3.09899238
46positive regulation of mast cell degranulation (GO:0043306)3.09899238
47single strand break repair (GO:0000012)3.09507812
48regulation of pigment cell differentiation (GO:0050932)3.08623268
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.05961033
50somatic diversification of immune receptors via somatic mutation (GO:0002566)3.05961033
51dopamine biosynthetic process (GO:0042416)3.05748621
52positive regulation of alpha-beta T cell proliferation (GO:0046641)3.04758694
53positive regulation of male gonad development (GO:2000020)3.04268657
54piRNA metabolic process (GO:0034587)2.97234206
55phosphatidylethanolamine biosynthetic process (GO:0006646)2.97093157
56regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.96323267
57meiotic chromosome segregation (GO:0045132)2.94658612
58synapsis (GO:0007129)2.94494992
59DNA-dependent DNA replication (GO:0006261)2.89601327
60positive regulation of DNA repair (GO:0045739)2.88335486
61limb bud formation (GO:0060174)2.87461814
62left/right axis specification (GO:0070986)2.87126419
63centrosome organization (GO:0051297)2.85833906
64positive regulation of meiosis (GO:0045836)2.84991228
65mismatch repair (GO:0006298)2.84627131
66regulation of centrosome duplication (GO:0010824)2.83692058
67adenosine metabolic process (GO:0046085)2.83203583
68mitochondrial respiratory chain complex I assembly (GO:0032981)2.82149115
69NADH dehydrogenase complex assembly (GO:0010257)2.82149115
70mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82149115
71protein neddylation (GO:0045116)2.81944082
72phosphatidylethanolamine metabolic process (GO:0046337)2.79931956
73protein complex biogenesis (GO:0070271)2.78951892
74microtubule organizing center organization (GO:0031023)2.77513929
75regulation of centrosome cycle (GO:0046605)2.75933135
76inner ear receptor cell development (GO:0060119)2.72083375
77phosphorelay signal transduction system (GO:0000160)2.71548486
78negative regulation of mRNA processing (GO:0050686)2.70316897
79positive regulation of meiotic cell cycle (GO:0051446)2.69080249
80postreplication repair (GO:0006301)2.68419123
81regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.66787230
82keratinocyte development (GO:0003334)2.65556731
83cullin deneddylation (GO:0010388)2.62200984
84mitotic G2/M transition checkpoint (GO:0044818)2.59569397
85regulation of T cell chemotaxis (GO:0010819)2.59090460
86positive regulation of T cell chemotaxis (GO:0010820)2.59090460
87dopamine transport (GO:0015872)2.57991922
88mitochondrial respiratory chain complex assembly (GO:0033108)2.57632171
89somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.57217135
90isotype switching (GO:0045190)2.57217135
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.57217135
92male meiosis I (GO:0007141)2.56525775
93intraciliary transport (GO:0042073)2.54194550
94RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.53965299
95DNA damage response, detection of DNA damage (GO:0042769)2.53890950
96preassembly of GPI anchor in ER membrane (GO:0016254)2.53101544
97deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.51576233
98exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51221486
99positive regulation of mast cell activation (GO:0033005)2.49417097
100DNA replication-independent nucleosome organization (GO:0034724)2.47695598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.84978181
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46276797
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40640624
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.34328038
5VDR_22108803_ChIP-Seq_LS180_Human2.93554162
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.62548692
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.59728573
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.57933257
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.53964412
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.47773420
11FUS_26573619_Chip-Seq_HEK293_Human2.44878622
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.28248750
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26417979
14ELK1_19687146_ChIP-ChIP_HELA_Human2.25730885
15EWS_26573619_Chip-Seq_HEK293_Human2.17227633
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.15125844
17IGF1R_20145208_ChIP-Seq_DFB_Human2.14170003
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13633372
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09620099
20TAF15_26573619_Chip-Seq_HEK293_Human2.07013872
21ZNF274_21170338_ChIP-Seq_K562_Hela2.06052217
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.03511870
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.00670165
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96729542
25TP63_19390658_ChIP-ChIP_HaCaT_Human1.96595247
26VDR_23849224_ChIP-Seq_CD4+_Human1.89868163
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85421284
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84569366
29GATA1_22025678_ChIP-Seq_K562_Human1.80346708
30P300_19829295_ChIP-Seq_ESCs_Human1.80275411
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80022532
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72492245
33MYC_18940864_ChIP-ChIP_HL60_Human1.65001262
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63687400
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62861906
36FOXP3_21729870_ChIP-Seq_TREG_Human1.61697877
37ER_23166858_ChIP-Seq_MCF-7_Human1.59748742
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56905262
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.49122348
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46180529
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41008322
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.39788779
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35711261
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33401422
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33185136
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.32966350
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31915523
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29517216
49TP53_22573176_ChIP-Seq_HFKS_Human1.29413500
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28103901
51CBP_20019798_ChIP-Seq_JUKART_Human1.28103901
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.27891771
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27548579
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.26717713
55GBX2_23144817_ChIP-Seq_PC3_Human1.23596917
56ETS1_20019798_ChIP-Seq_JURKAT_Human1.23586608
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23469295
58SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23080085
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.23038272
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.19823224
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19798746
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19545077
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18029952
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17966178
65CRX_20693478_ChIP-Seq_RETINA_Mouse1.17850648
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16894821
67P300_18555785_Chip-Seq_ESCs_Mouse1.16798564
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15661318
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.15083202
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14724324
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.14472926
72IRF8_21731497_ChIP-ChIP_J774_Mouse1.14089321
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.13735439
74P53_22387025_ChIP-Seq_ESCs_Mouse1.13507934
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12845827
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12375686
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12375686
78GATA3_26560356_Chip-Seq_TH2_Human1.12304737
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10924807
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.10521749
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09913704
82STAT3_23295773_ChIP-Seq_U87_Human1.09650693
83NANOG_19829295_ChIP-Seq_ESCs_Human1.09252825
84SOX2_19829295_ChIP-Seq_ESCs_Human1.09252825
85STAT3_18555785_Chip-Seq_ESCs_Mouse1.08747559
86RBPJ_21746931_ChIP-Seq_IB4_Human1.08648056
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.07682556
88BCAT_22108803_ChIP-Seq_LS180_Human1.07523150
89FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07047498
90IRF1_19129219_ChIP-ChIP_H3396_Human1.07034870
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06231111
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06134588
93AR_25329375_ChIP-Seq_VCAP_Human1.05247090
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04563311
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.03802051
96TCF4_23295773_ChIP-Seq_U87_Human1.03643361
97SMAD4_21799915_ChIP-Seq_A2780_Human1.03008314
98TCF4_22108803_ChIP-Seq_LS180_Human1.02735066
99EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01597817
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01528443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation5.48165506
2MP0008057_abnormal_DNA_replication4.70814214
3MP0004043_abnormal_pH_regulation3.64016887
4MP0003950_abnormal_plasma_membrane3.58328717
5MP0008058_abnormal_DNA_repair3.07155922
6MP0000372_irregular_coat_pigmentation2.87546591
7MP0010094_abnormal_chromosome_stability2.60365832
8MP0003123_paternal_imprinting2.59359234
9MP0006292_abnormal_olfactory_placode2.37946357
10MP0000569_abnormal_digit_pigmentation2.36595787
11MP0003786_premature_aging2.30334500
12MP0006072_abnormal_retinal_apoptosis2.29975885
13MP0001188_hyperpigmentation2.04352505
14MP0004957_abnormal_blastocyst_morpholog1.94973634
15MP0005075_abnormal_melanosome_morpholog1.93409741
16MP0001984_abnormal_olfaction1.84071908
17MP0002938_white_spotting1.78736662
18MP0003693_abnormal_embryo_hatching1.77466525
19MP0005671_abnormal_response_to1.72313152
20MP0003111_abnormal_nucleus_morphology1.70197774
21MP0005551_abnormal_eye_electrophysiolog1.67168314
22MP0001501_abnormal_sleep_pattern1.65916264
23MP0002102_abnormal_ear_morphology1.62925363
24MP0008877_abnormal_DNA_methylation1.55279958
25MP0002090_abnormal_vision1.47658819
26MP0002148_abnormal_hypersensitivity_rea1.45442808
27MP0003718_maternal_effect1.38346876
28MP0005253_abnormal_eye_physiology1.36079192
29MP0005174_abnormal_tail_pigmentation1.34608257
30MP0002876_abnormal_thyroid_physiology1.32500983
31MP0003077_abnormal_cell_cycle1.30955593
32MP0003763_abnormal_thymus_physiology1.30807822
33MP0000427_abnormal_hair_cycle1.26587483
34MP0005310_abnormal_salivary_gland1.23653755
35MP0004381_abnormal_hair_follicle1.14936700
36MP0009333_abnormal_splenocyte_physiolog1.13985020
37MP0002095_abnormal_skin_pigmentation1.13169175
38MP0009785_altered_susceptibility_to1.09050742
39MP0001835_abnormal_antigen_presentation1.08958074
40MP0005367_renal/urinary_system_phenotyp1.08305382
41MP0000516_abnormal_urinary_system1.08305382
42MP0008789_abnormal_olfactory_epithelium1.07837103
43MP0001764_abnormal_homeostasis1.07070133
44MP0000647_abnormal_sebaceous_gland1.05588142
45MP0000015_abnormal_ear_pigmentation1.03277214
46MP0004885_abnormal_endolymph1.02987450
47MP0003943_abnormal_hepatobiliary_system1.02696094
48MP0001119_abnormal_female_reproductive1.01997588
49MP0003646_muscle_fatigue1.01544157
50MP0000631_abnormal_neuroendocrine_gland1.01445016
51MP0009379_abnormal_foot_pigmentation0.99836899
52MP0001873_stomach_inflammation0.99554223
53MP0006035_abnormal_mitochondrial_morpho0.99057861
54MP0002210_abnormal_sex_determination0.97398858
55MP0005646_abnormal_pituitary_gland0.97092236
56MP0003121_genomic_imprinting0.97025598
57MP0002751_abnormal_autonomic_nervous0.96724800
58MP0001929_abnormal_gametogenesis0.95673606
59MP0008872_abnormal_physiological_respon0.95260314
60MP0003698_abnormal_male_reproductive0.94832534
61MP0003136_yellow_coat_color0.94787435
62MP0002398_abnormal_bone_marrow0.90240601
63MP0001800_abnormal_humoral_immune0.89934488
64MP0006036_abnormal_mitochondrial_physio0.89578173
65MP0008932_abnormal_embryonic_tissue0.89541528
66MP0000465_gastrointestinal_hemorrhage0.89433861
67MP0001177_atelectasis0.88798789
68MP0002163_abnormal_gland_morphology0.85514367
69MP0006082_CNS_inflammation0.85195504
70MP0003937_abnormal_limbs/digits/tail_de0.84743614
71MP0003567_abnormal_fetal_cardiomyocyte0.84626038
72MP0000703_abnormal_thymus_morphology0.84375116
73MP0005394_taste/olfaction_phenotype0.84033963
74MP0005499_abnormal_olfactory_system0.84033963
75MP0002019_abnormal_tumor_incidence0.83069237
76MP0002822_catalepsy0.82065005
77MP0005645_abnormal_hypothalamus_physiol0.82021554
78MP0000653_abnormal_sex_gland0.80257073
79MP0001293_anophthalmia0.79778725
80MP0009745_abnormal_behavioral_response0.79515370
81MP0002006_tumorigenesis0.78118931
82MP0002653_abnormal_ependyma_morphology0.77930449
83MP0003195_calcinosis0.76712892
84MP0003724_increased_susceptibility_to0.74044039
85MP0000716_abnormal_immune_system0.73199829
86MP0003880_abnormal_central_pattern0.72081406
87MP0009764_decreased_sensitivity_to0.71414751
88MP0005084_abnormal_gallbladder_morpholo0.71240423
89MP0004147_increased_porphyrin_level0.70555002
90MP0008873_increased_physiological_sensi0.70310966
91MP0000689_abnormal_spleen_morphology0.69045382
92MP0002420_abnormal_adaptive_immunity0.68310160
93MP0001324_abnormal_eye_pigmentation0.67778821
94MP0001819_abnormal_immune_cell0.67360030
95MP0000685_abnormal_immune_system0.67170264
96MP0005000_abnormal_immune_tolerance0.66751021
97MP0002723_abnormal_immune_serum0.66236794
98MP0002272_abnormal_nervous_system0.66123278
99MP0003699_abnormal_female_reproductive0.66102094
100MP0001145_abnormal_male_reproductive0.64066075

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)4.07884618
2Volvulus (HP:0002580)3.93986596
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.63284143
4Congenital stationary night blindness (HP:0007642)3.41066928
5Chronic bronchitis (HP:0004469)3.37956984
6Abnormality of the renal medulla (HP:0100957)3.26128629
7Chromsome breakage (HP:0040012)3.24034306
8Pancreatic cysts (HP:0001737)3.14695353
9Severe combined immunodeficiency (HP:0004430)3.09196310
10Intestinal atresia (HP:0011100)3.01200228
11Renal cortical cysts (HP:0000803)2.89901083
12Pancreatic fibrosis (HP:0100732)2.84301161
13True hermaphroditism (HP:0010459)2.81328097
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74294036
15Medial flaring of the eyebrow (HP:0010747)2.70724302
16Abnormality of midbrain morphology (HP:0002418)2.70397230
17Molar tooth sign on MRI (HP:0002419)2.70397230
18Thyroiditis (HP:0100646)2.70265344
19Concave nail (HP:0001598)2.69818380
20Abnormality of B cell number (HP:0010975)2.65614732
21Combined immunodeficiency (HP:0005387)2.64597316
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.58457204
23Abnormality of the renal cortex (HP:0011035)2.55569509
24B lymphocytopenia (HP:0010976)2.53866250
25Postaxial foot polydactyly (HP:0001830)2.53791528
26IgG deficiency (HP:0004315)2.53630657
27Stomach cancer (HP:0012126)2.47775174
28Acute lymphatic leukemia (HP:0006721)2.45307788
29Clubbing of toes (HP:0100760)2.39926073
30Acute necrotizing encephalopathy (HP:0006965)2.37173189
31Duplicated collecting system (HP:0000081)2.35454083
323-Methylglutaconic aciduria (HP:0003535)2.35165469
33Increased CSF lactate (HP:0002490)2.34904591
34Meckel diverticulum (HP:0002245)2.30298669
35Mitochondrial inheritance (HP:0001427)2.29752180
36Abnormality of the ileum (HP:0001549)2.28871336
37Abnormality of chromosome stability (HP:0003220)2.27064127
38Congenital primary aphakia (HP:0007707)2.26224453
39Progressive inability to walk (HP:0002505)2.23929935
40Abnormality of the preputium (HP:0100587)2.21518827
41Abnormality of the renal collecting system (HP:0004742)2.20842100
42Abolished electroretinogram (ERG) (HP:0000550)2.20043906
43Hypoproteinemia (HP:0003075)2.19523146
44Sloping forehead (HP:0000340)2.18481602
45Exertional dyspnea (HP:0002875)2.16824470
46Abnormality of eosinophils (HP:0001879)2.15256127
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.14974943
48Abnormality of alanine metabolism (HP:0010916)2.14974943
49Hyperalaninemia (HP:0003348)2.14974943
50Gait imbalance (HP:0002141)2.13716124
51Stomatitis (HP:0010280)2.11258555
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.10854051
53Absent/shortened dynein arms (HP:0200106)2.10854051
54Aqueductal stenosis (HP:0002410)2.10615218
55Abnormality of the labia minora (HP:0012880)2.08834939
56Aplasia/Hypoplasia of the tongue (HP:0010295)2.06427195
57Hypoplastic iliac wings (HP:0002866)2.04949070
58Abnormality of the pons (HP:0007361)2.03343831
59Microvesicular hepatic steatosis (HP:0001414)2.03300731
60Duodenal stenosis (HP:0100867)2.02754848
61Small intestinal stenosis (HP:0012848)2.02754848
62Acute encephalopathy (HP:0006846)2.01149779
63Facial diplegia (HP:0001349)2.00837090
64Colon cancer (HP:0003003)1.99367519
65Gaze-evoked nystagmus (HP:0000640)1.98695318
66Hypoplasia of the fovea (HP:0007750)1.94267565
67Aplasia/Hypoplasia of the fovea (HP:0008060)1.94267565
68Abnormality of the duodenum (HP:0002246)1.93807667
69Oligodactyly (hands) (HP:0001180)1.93442097
70Abnormality of T cell number (HP:0011839)1.93365715
71Abnormal mitochondria in muscle tissue (HP:0008316)1.90781970
72Myelodysplasia (HP:0002863)1.90552467
73Progressive macrocephaly (HP:0004481)1.89642975
74Vaginal atresia (HP:0000148)1.89318739
75Increased hepatocellular lipid droplets (HP:0006565)1.88561265
76Nephrogenic diabetes insipidus (HP:0009806)1.87967854
77Genital tract atresia (HP:0001827)1.87627119
78Methylmalonic acidemia (HP:0002912)1.87362154
79Triphalangeal thumb (HP:0001199)1.87129791
80Astigmatism (HP:0000483)1.86707626
81Hypothermia (HP:0002045)1.86475150
82Congenital, generalized hypertrichosis (HP:0004540)1.86248608
83Cerebral hypomyelination (HP:0006808)1.85429975
84Abnormality of renal resorption (HP:0011038)1.84959277
85Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.82760221
86Preaxial hand polydactyly (HP:0001177)1.80474377
87Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80340248
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79428452
89Abnormality of T cells (HP:0002843)1.78312287
90Cystic liver disease (HP:0006706)1.77807396
91Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77140044
92Aplasia/Hypoplasia of the earlobes (HP:0009906)1.76382246
93Inability to walk (HP:0002540)1.76324816
94Anencephaly (HP:0002323)1.76088985
95Absent speech (HP:0001344)1.75720783
96Hepatocellular necrosis (HP:0001404)1.73880158
97Premature ovarian failure (HP:0008209)1.72912678
98Abnormal lung lobation (HP:0002101)1.72239317
99Carpal bone hypoplasia (HP:0001498)1.71881993
100Absent radius (HP:0003974)1.71633978

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK16.37084971
2LATS16.17561066
3NUAK15.09737336
4MAP4K24.28498097
5PLK43.11292371
6IRAK22.81295316
7NEK22.73345779
8CDC72.37389613
9ERBB32.26480514
10IRAK12.23800970
11EIF2AK32.03149229
12ZAK1.82985515
13BUB11.80276770
14TAOK31.52390208
15WEE11.51571647
16ACVR1B1.47047721
17STK31.45416662
18FRK1.37185134
19TAF11.31216264
20ADRBK21.28107596
21GRK11.26679827
22VRK21.24163518
23TRIM281.23991913
24MST41.16970402
25PNCK1.15128735
26BMPR1B1.10563518
27MKNK21.07083967
28BMPR21.04731150
29AKT31.03467147
30PLK21.01340693
31BRSK20.99946280
32VRK10.97085896
33TSSK60.96941217
34TXK0.95765513
35RPS6KA40.94708034
36MKNK10.94209187
37EIF2AK20.94016321
38CAMK1D0.92484410
39BCR0.89610231
40SRPK10.87465495
41PLK30.85907361
42MAPK130.84974878
43EIF2AK10.84942582
44WNK30.79859832
45TNIK0.79176865
46PDK20.76752824
47PBK0.76619464
48CDK80.70746571
49TLK10.70363647
50CAMK1G0.70008867
51SIK20.67952269
52CDK190.64711511
53CSNK1G20.63313540
54TEC0.60829055
55OXSR10.59250845
56AURKB0.58898961
57PLK10.58278111
58STK38L0.55405442
59TTK0.44227799
60DYRK30.44108576
61CHEK20.43151530
62ATR0.41846871
63FLT30.39835251
64ATM0.39091862
65MAPKAPK50.38941750
66DAPK10.38178114
67SIK30.37029080
68PIK3CG0.35007001
69TYK20.31178971
70STK160.31083357
71INSRR0.30953136
72CSNK1G10.30402508
73CSNK1A10.30080442
74PRKCQ0.29646614
75CDK30.29376289
76CSNK1G30.29318814
77GRK50.28412732
78CAMK10.28257426
79ITK0.27902523
80TGFBR10.26719187
81CAMKK20.26540185
82IKBKB0.26349874
83RPS6KA50.25079535
84CSNK2A20.24556719
85STK40.23936650
86MELK0.23783879
87CCNB10.23783117
88MARK30.21859452
89ERBB40.21473543
90SYK0.20344891
91CHEK10.20148485
92PIM10.19874337
93CSNK1E0.19837278
94CSNK1D0.19404923
95CSNK2A10.19397516
96PRKG10.18906052
97GRK70.18152671
98NTRK30.17201670
99IGF1R0.16786602
100EPHA40.15673331

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.41111630
2Proteasome_Homo sapiens_hsa030503.32546608
3Homologous recombination_Homo sapiens_hsa034403.21254267
4Basal transcription factors_Homo sapiens_hsa030223.15430258
5Mismatch repair_Homo sapiens_hsa034302.59355788
6Fanconi anemia pathway_Homo sapiens_hsa034602.42117200
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33933630
8Nucleotide excision repair_Homo sapiens_hsa034202.24747359
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21733720
10RNA degradation_Homo sapiens_hsa030182.14345984
11Non-homologous end-joining_Homo sapiens_hsa034502.12616362
12Primary immunodeficiency_Homo sapiens_hsa053402.07952263
13Fatty acid elongation_Homo sapiens_hsa000622.04303080
14Allograft rejection_Homo sapiens_hsa053302.04278641
15Autoimmune thyroid disease_Homo sapiens_hsa053201.99781346
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.93984019
17DNA replication_Homo sapiens_hsa030301.84927604
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77368673
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68192489
20Oxidative phosphorylation_Homo sapiens_hsa001901.64909092
21Graft-versus-host disease_Homo sapiens_hsa053321.62626106
22RNA transport_Homo sapiens_hsa030131.57371802
23Propanoate metabolism_Homo sapiens_hsa006401.55373360
24Parkinsons disease_Homo sapiens_hsa050121.49856787
25Cell cycle_Homo sapiens_hsa041101.44712809
26RNA polymerase_Homo sapiens_hsa030201.44683567
27Protein export_Homo sapiens_hsa030601.43280471
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35818314
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35767043
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34157450
31Type I diabetes mellitus_Homo sapiens_hsa049401.33598540
32Base excision repair_Homo sapiens_hsa034101.32676025
33One carbon pool by folate_Homo sapiens_hsa006701.19023042
34p53 signaling pathway_Homo sapiens_hsa041151.13234500
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12184706
36Ether lipid metabolism_Homo sapiens_hsa005651.11717378
37Spliceosome_Homo sapiens_hsa030401.07648607
38Nicotine addiction_Homo sapiens_hsa050331.07172195
39Selenocompound metabolism_Homo sapiens_hsa004501.06061625
40Huntingtons disease_Homo sapiens_hsa050161.05260751
41Caffeine metabolism_Homo sapiens_hsa002321.04726938
42Nitrogen metabolism_Homo sapiens_hsa009101.03953682
43Chemical carcinogenesis_Homo sapiens_hsa052041.03357440
44Regulation of autophagy_Homo sapiens_hsa041401.01566586
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97390547
46Butanoate metabolism_Homo sapiens_hsa006500.96816409
47Sulfur metabolism_Homo sapiens_hsa009200.95430495
48Alzheimers disease_Homo sapiens_hsa050100.93867376
49Phototransduction_Homo sapiens_hsa047440.92245428
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92169167
51Herpes simplex infection_Homo sapiens_hsa051680.91104553
52Linoleic acid metabolism_Homo sapiens_hsa005910.90725374
53Peroxisome_Homo sapiens_hsa041460.90450663
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89505091
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87579731
56Ribosome_Homo sapiens_hsa030100.87409954
57Antigen processing and presentation_Homo sapiens_hsa046120.85319249
58Oocyte meiosis_Homo sapiens_hsa041140.83449765
59mRNA surveillance pathway_Homo sapiens_hsa030150.83422059
60Purine metabolism_Homo sapiens_hsa002300.80857067
61Pyrimidine metabolism_Homo sapiens_hsa002400.78472702
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.75512524
63Retinol metabolism_Homo sapiens_hsa008300.72986230
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72285132
65Rheumatoid arthritis_Homo sapiens_hsa053230.71983384
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.71014470
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68347162
68African trypanosomiasis_Homo sapiens_hsa051430.67670608
69Systemic lupus erythematosus_Homo sapiens_hsa053220.67645349
70Legionellosis_Homo sapiens_hsa051340.67444007
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64748671
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63013241
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60317634
74Hematopoietic cell lineage_Homo sapiens_hsa046400.60263008
75Tryptophan metabolism_Homo sapiens_hsa003800.60193038
76Taste transduction_Homo sapiens_hsa047420.58985610
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.58819979
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57552330
79Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54347528
80Salivary secretion_Homo sapiens_hsa049700.51947452
81Viral myocarditis_Homo sapiens_hsa054160.49254441
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43719707
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.42820773
84Epstein-Barr virus infection_Homo sapiens_hsa051690.42712594
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42333216
86Measles_Homo sapiens_hsa051620.41494935
87Olfactory transduction_Homo sapiens_hsa047400.40078545
88Lysine degradation_Homo sapiens_hsa003100.39699247
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.38550454
90Dorso-ventral axis formation_Homo sapiens_hsa043200.36210611
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36183498
92Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35386601
93Fatty acid metabolism_Homo sapiens_hsa012120.32461742
94Glutathione metabolism_Homo sapiens_hsa004800.29939084
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28101427
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.27590483
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27440402
98Fatty acid degradation_Homo sapiens_hsa000710.27152506
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26988295
100Pyruvate metabolism_Homo sapiens_hsa006200.26609047

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