PABPC1P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)6.23324991
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.48384030
3viral transcription (GO:0019083)5.41130855
4translational termination (GO:0006415)5.23826280
5mitochondrial fragmentation involved in apoptotic process (GO:0043653)5.22886153
6ribosomal small subunit assembly (GO:0000028)5.20959791
7ATP synthesis coupled proton transport (GO:0015986)5.01898383
8energy coupled proton transport, down electrochemical gradient (GO:0015985)5.01898383
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.84661423
10negative regulation of activin receptor signaling pathway (GO:0032926)4.83480025
11cotranslational protein targeting to membrane (GO:0006613)4.82326962
12protein targeting to ER (GO:0045047)4.77336374
13regulation of mesoderm development (GO:2000380)4.66515299
14maturation of SSU-rRNA (GO:0030490)4.60561004
15translational elongation (GO:0006414)4.58547669
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.57333620
17viral life cycle (GO:0019058)4.54438462
18regulation of activin receptor signaling pathway (GO:0032925)4.40929791
19protein localization to endoplasmic reticulum (GO:0070972)4.40915689
20anterograde synaptic vesicle transport (GO:0048490)4.21630564
21cellular protein complex disassembly (GO:0043624)4.09643461
22sequestering of extracellular ligand from receptor (GO:0035581)3.96377873
23photoreceptor cell maintenance (GO:0045494)3.96014485
24cell migration involved in gastrulation (GO:0042074)3.91297439
25nodal signaling pathway (GO:0038092)3.90728503
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.88092206
27mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.87253239
28respiratory electron transport chain (GO:0022904)3.85370243
29electron transport chain (GO:0022900)3.80620969
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79883350
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.78507943
32regulation of development, heterochronic (GO:0040034)3.74724302
33postsynaptic membrane organization (GO:0001941)3.71437999
34platelet dense granule organization (GO:0060155)3.65860946
35regulation of timing of cell differentiation (GO:0048505)3.59042912
36anterograde axon cargo transport (GO:0008089)3.56718627
37translational initiation (GO:0006413)3.54970301
38head development (GO:0060322)3.50231289
39histone exchange (GO:0043486)3.47241349
40behavioral response to nicotine (GO:0035095)3.46736867
41centriole replication (GO:0007099)3.45543320
42signal transduction involved in regulation of gene expression (GO:0023019)3.45513125
43mannosylation (GO:0097502)3.45159947
44termination of RNA polymerase III transcription (GO:0006386)3.41965123
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.41965123
46primitive streak formation (GO:0090009)3.40257055
47detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.35740474
48protein complex disassembly (GO:0043241)3.35406126
49L-serine metabolic process (GO:0006563)3.34734302
50melanosome organization (GO:0032438)3.31889661
51ribosomal small subunit biogenesis (GO:0042274)3.29319704
52epithelial cilium movement (GO:0003351)3.25791716
53protein neddylation (GO:0045116)3.20611037
54protein heterotetramerization (GO:0051290)3.19343108
55macromolecular complex disassembly (GO:0032984)3.18529181
56positive regulation of gastrulation (GO:2000543)3.18492028
57protein targeting to membrane (GO:0006612)3.17630308
58pigment granule organization (GO:0048753)3.17282812
59nuclear-transcribed mRNA catabolic process (GO:0000956)3.14796971
60cullin deneddylation (GO:0010388)3.13742844
61L-ascorbic acid metabolic process (GO:0019852)3.06261067
62serotonin receptor signaling pathway (GO:0007210)3.04621857
63phosphorelay signal transduction system (GO:0000160)3.03523549
64mitochondrial fission (GO:0000266)3.02019378
65translation (GO:0006412)2.98563132
66positive regulation of mitochondrial fission (GO:0090141)2.95841232
67positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.95031250
68organelle disassembly (GO:1903008)2.92324685
69oxidative phosphorylation (GO:0006119)2.89936147
70mRNA catabolic process (GO:0006402)2.89267471
71rRNA modification (GO:0000154)2.89062835
72ATP biosynthetic process (GO:0006754)2.84821996
73inner ear receptor cell differentiation (GO:0060113)2.84241151
74spliceosomal complex assembly (GO:0000245)2.83634242
75regulation of transmission of nerve impulse (GO:0051969)2.82940132
76DNA integration (GO:0015074)2.82681570
77deoxyribose phosphate catabolic process (GO:0046386)2.82032028
78deoxyribonucleotide catabolic process (GO:0009264)2.80973611
79CENP-A containing nucleosome assembly (GO:0034080)2.80190028
80regulation of cilium movement (GO:0003352)2.79746304
81spermatid nucleus differentiation (GO:0007289)2.77234827
82activin receptor signaling pathway (GO:0032924)2.76094059
83nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73331370
84DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.72133419
85negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.71592883
86negative regulation of calcium ion transport into cytosol (GO:0010523)2.71439282
87nucleotide transmembrane transport (GO:1901679)2.69579452
88microtubule depolymerization (GO:0007019)2.68171639
89detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.68116816
90signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.67670192
91signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.67670192
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.67670192
93DNA deamination (GO:0045006)2.67524547
94chromatin remodeling at centromere (GO:0031055)2.66559387
95purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.66423380
96pyrimidine nucleobase catabolic process (GO:0006208)2.65823955
97aldehyde catabolic process (GO:0046185)2.65177111
98regulation of DNA endoreduplication (GO:0032875)2.64277797
99hydrogen ion transmembrane transport (GO:1902600)2.63947585
100axonemal dynein complex assembly (GO:0070286)2.62316042

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.39439944
2EST1_17652178_ChIP-ChIP_JURKAT_Human4.11478001
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.90315016
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.63993085
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50605821
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43866547
7ZNF274_21170338_ChIP-Seq_K562_Hela3.07053127
8FUS_26573619_Chip-Seq_HEK293_Human2.79241397
9VDR_22108803_ChIP-Seq_LS180_Human2.70596281
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58635286
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.54165991
12ELK1_19687146_ChIP-ChIP_HELA_Human2.50323806
13TAF15_26573619_Chip-Seq_HEK293_Human2.40191435
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.35019218
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.34745467
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.27458935
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22215171
18P300_19829295_ChIP-Seq_ESCs_Human2.11272400
19VDR_23849224_ChIP-Seq_CD4+_Human2.09973366
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.09069597
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.03951707
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99032564
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98898499
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93720141
25JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85045667
26IGF1R_20145208_ChIP-Seq_DFB_Human1.81287727
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.80679112
28MYC_18940864_ChIP-ChIP_HL60_Human1.72318870
29EWS_26573619_Chip-Seq_HEK293_Human1.71733089
30FOXP3_21729870_ChIP-Seq_TREG_Human1.69421863
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62033526
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55509334
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55509334
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55509334
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50137484
36IRF1_19129219_ChIP-ChIP_H3396_Human1.47122436
37TTF2_22483619_ChIP-Seq_HELA_Human1.43101482
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42161497
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.41693693
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.40638302
41SOX2_19829295_ChIP-Seq_ESCs_Human1.39095554
42NANOG_19829295_ChIP-Seq_ESCs_Human1.39095554
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37737165
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35601254
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33729705
46HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33606196
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33501961
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32836465
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32471984
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31675326
51BCAT_22108803_ChIP-Seq_LS180_Human1.31528207
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30834058
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28058356
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.27426168
55AR_20517297_ChIP-Seq_VCAP_Human1.26534552
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.25187128
57DCP1A_22483619_ChIP-Seq_HELA_Human1.23760609
58NANOG_16153702_ChIP-ChIP_HESCs_Human1.23169962
59TCF4_22108803_ChIP-Seq_LS180_Human1.23148243
60SMAD3_21741376_ChIP-Seq_HESCs_Human1.22399497
61FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21663219
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21224578
63ER_23166858_ChIP-Seq_MCF-7_Human1.20549345
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19950309
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.16238040
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.14974545
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14974545
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14278618
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13649039
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11224304
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11031592
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.10480684
73ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09752410
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09683452
75SMAD3_21741376_ChIP-Seq_ESCs_Human1.09611461
76CBP_20019798_ChIP-Seq_JUKART_Human1.09353869
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09353869
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08515594
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.07679183
80ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07381292
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06239446
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04025647
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03797597
84MYC_19829295_ChIP-Seq_ESCs_Human1.03584503
85RNF2_27304074_Chip-Seq_NSC_Mouse1.02243024
86ELF5_23300383_ChIP-Seq_T47D_Human1.01678800
87CBX2_27304074_Chip-Seq_ESCs_Mouse0.99732187
88TP53_22573176_ChIP-Seq_HFKS_Human0.99479783
89AR_25329375_ChIP-Seq_VCAP_Human0.99479609
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98980008
91SMAD3_21741376_ChIP-Seq_EPCs_Human0.97009814
92E2F1_18555785_ChIP-Seq_MESCs_Mouse0.94433117
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94160738
94MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.93526955
95ERG_20517297_ChIP-Seq_VCAP_Human0.93476679
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93186582
97SPI1_20517297_ChIP-Seq_HL60_Human0.93010403
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.91627087
99XRN2_22483619_ChIP-Seq_HELA_Human0.90557349
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.90078576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.63448758
2MP0003890_abnormal_embryonic-extraembry4.41745765
3MP0009379_abnormal_foot_pigmentation4.15274254
4MP0003283_abnormal_digestive_organ4.10539476
5MP0010030_abnormal_orbit_morphology3.57673366
6MP0004133_heterotaxia3.45962167
7MP0006292_abnormal_olfactory_placode3.32496346
8MP0000372_irregular_coat_pigmentation3.24934133
9MP0003136_yellow_coat_color3.14706180
10MP0000566_synostosis2.70207092
11MP0001529_abnormal_vocalization2.63285740
12MP0002102_abnormal_ear_morphology2.61316185
13MP0002938_white_spotting2.53639051
14MP0001485_abnormal_pinna_reflex2.40903323
15MP0004742_abnormal_vestibular_system2.36522681
16MP0005645_abnormal_hypothalamus_physiol2.34143081
17MP0002234_abnormal_pharynx_morphology2.22043367
18MP0001293_anophthalmia2.10947761
19MP0006072_abnormal_retinal_apoptosis2.07913921
20MP0003119_abnormal_digestive_system1.80640290
21MP0005075_abnormal_melanosome_morpholog1.72701762
22MP0005174_abnormal_tail_pigmentation1.66147418
23MP0000015_abnormal_ear_pigmentation1.66141868
24MP0005394_taste/olfaction_phenotype1.57660716
25MP0005499_abnormal_olfactory_system1.57660716
26MP0006276_abnormal_autonomic_nervous1.56778797
27MP0003880_abnormal_central_pattern1.55753557
28MP0004264_abnormal_extraembryonic_tissu1.53134002
29MP0003878_abnormal_ear_physiology1.50926313
30MP0005377_hearing/vestibular/ear_phenot1.50926313
31MP0001286_abnormal_eye_development1.40867497
32MP0002638_abnormal_pupillary_reflex1.32470754
33MP0002277_abnormal_respiratory_mucosa1.28732403
34MP0002095_abnormal_skin_pigmentation1.27275754
35MP0008058_abnormal_DNA_repair1.26710113
36MP0000516_abnormal_urinary_system1.22075412
37MP0005367_renal/urinary_system_phenotyp1.22075412
38MP0003787_abnormal_imprinting1.21948204
39MP0003122_maternal_imprinting1.21261392
40MP0000026_abnormal_inner_ear1.20011652
41MP0005084_abnormal_gallbladder_morpholo1.19591283
42MP0005671_abnormal_response_to1.19219798
43MP0000631_abnormal_neuroendocrine_gland1.18207996
44MP0008789_abnormal_olfactory_epithelium1.17857237
45MP0001188_hyperpigmentation1.14653112
46MP0002736_abnormal_nociception_after1.14520540
47MP0005083_abnormal_biliary_tract1.14188856
48MP0003938_abnormal_ear_development1.13116934
49MP0002282_abnormal_trachea_morphology1.12842658
50MP0005423_abnormal_somatic_nervous1.10443079
51MP0002138_abnormal_hepatobiliary_system1.09107242
52MP0004142_abnormal_muscle_tone1.07501299
53MP0008877_abnormal_DNA_methylation1.02591135
54MP0002396_abnormal_hematopoietic_system1.00467207
55MP0004145_abnormal_muscle_electrophysio0.99414421
56MP0005646_abnormal_pituitary_gland0.98947522
57MP0005085_abnormal_gallbladder_physiolo0.98237454
58MP0002233_abnormal_nose_morphology0.97087423
59MP0003137_abnormal_impulse_conducting0.96395034
60MP0001968_abnormal_touch/_nociception0.94742645
61MP0008961_abnormal_basal_metabolism0.92607231
62MP0001963_abnormal_hearing_physiology0.88385373
63MP0008872_abnormal_physiological_respon0.87345822
64MP0009046_muscle_twitch0.87095582
65MP0001881_abnormal_mammary_gland0.85024155
66MP0001764_abnormal_homeostasis0.84241522
67MP0003121_genomic_imprinting0.82893280
68MP0005408_hypopigmentation0.81236782
69MP0003252_abnormal_bile_duct0.78539801
70MP0001486_abnormal_startle_reflex0.78183690
71MP0001346_abnormal_lacrimal_gland0.77749608
72MP0002177_abnormal_outer_ear0.77234025
73MP0005253_abnormal_eye_physiology0.76132152
74MP0005195_abnormal_posterior_eye0.75393647
75MP0003635_abnormal_synaptic_transmissio0.74727589
76MP0002837_dystrophic_cardiac_calcinosis0.73626025
77MP0001986_abnormal_taste_sensitivity0.73260998
78MP0002272_abnormal_nervous_system0.72481883
79MP0008004_abnormal_stomach_pH0.71576238
80MP0001324_abnormal_eye_pigmentation0.69666385
81MP0005551_abnormal_eye_electrophysiolog0.69009673
82MP0005391_vision/eye_phenotype0.68359591
83MP0002752_abnormal_somatic_nervous0.65499146
84MP0002075_abnormal_coat/hair_pigmentati0.65270611
85MP0000428_abnormal_craniofacial_morphol0.63555245
86MP0003937_abnormal_limbs/digits/tail_de0.63239715
87MP0008995_early_reproductive_senescence0.62794800
88MP0000462_abnormal_digestive_system0.62223368
89MP0000049_abnormal_middle_ear0.61721515
90MP0005197_abnormal_uvea_morphology0.60980591
91MP0009745_abnormal_behavioral_response0.59077190
92MP0001186_pigmentation_phenotype0.55977749
93MP0003959_abnormal_lean_body0.54306577
94MP0002295_abnormal_pulmonary_circulatio0.54285158
95MP0004885_abnormal_endolymph0.54042052
96MP0001970_abnormal_pain_threshold0.53883066
97MP0003186_abnormal_redox_activity0.53670079
98MP0002557_abnormal_social/conspecific_i0.53052010
99MP0002909_abnormal_adrenal_gland0.52730481
100MP0001929_abnormal_gametogenesis0.52595108

Predicted human phenotypes

RankGene SetZ-score
1Oligodactyly (hands) (HP:0001180)6.08161968
2Intestinal atresia (HP:0011100)5.73079186
3Nuclear cataract (HP:0100018)5.26587876
4Oligodactyly (HP:0012165)4.41619159
5Esophageal atresia (HP:0002032)4.39451868
6Congenital malformation of the right heart (HP:0011723)4.22578279
7Double outlet right ventricle (HP:0001719)4.22578279
8Aqueductal stenosis (HP:0002410)4.03031405
9Acute necrotizing encephalopathy (HP:0006965)3.89222882
10Reticulocytopenia (HP:0001896)3.88443183
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.83892815
12Chin dimple (HP:0010751)3.73553475
13Abnormal mitochondria in muscle tissue (HP:0008316)3.57928135
14Labial hypoplasia (HP:0000066)3.51237463
15Hypoplastic female external genitalia (HP:0012815)3.44069807
16Cleft eyelid (HP:0000625)3.37579653
17Gastrointestinal atresia (HP:0002589)3.21568762
18Progressive macrocephaly (HP:0004481)3.19815788
19Colon cancer (HP:0003003)3.16992149
20Hepatocellular necrosis (HP:0001404)3.16505121
21Acute encephalopathy (HP:0006846)3.10322623
22Mitochondrial inheritance (HP:0001427)3.06085824
23Bifid tongue (HP:0010297)3.03829506
24Anencephaly (HP:0002323)3.01690560
25Anophthalmia (HP:0000528)2.99709546
26Hepatic necrosis (HP:0002605)2.95879472
27Down-sloping shoulders (HP:0200021)2.95474824
28Absent radius (HP:0003974)2.88498786
29Abnormality of the pubic bones (HP:0003172)2.84712106
30Retinal dysplasia (HP:0007973)2.79668895
31Absent forearm bone (HP:0003953)2.79645224
32Aplasia involving forearm bones (HP:0009822)2.79645224
33Type II lissencephaly (HP:0007260)2.76650379
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73862925
35Absent eyebrow (HP:0002223)2.69841713
36Abnormal number of erythroid precursors (HP:0012131)2.67815365
37Abdominal situs inversus (HP:0003363)2.67435271
38Abnormality of abdominal situs (HP:0011620)2.67435271
39Abnormality of cells of the erythroid lineage (HP:0012130)2.65174715
40Triphalangeal thumb (HP:0001199)2.63776394
41Cupped ear (HP:0000378)2.62625627
42Pancreatic cysts (HP:0001737)2.61620270
43Abnormality of the parathyroid morphology (HP:0011766)2.59395829
44Renal hypoplasia (HP:0000089)2.59158691
45Increased CSF lactate (HP:0002490)2.56359195
46Abnormality of the labia (HP:0000058)2.56088296
47Cellular immunodeficiency (HP:0005374)2.52149375
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.46205036
49Hemivertebrae (HP:0002937)2.45959869
50Carpal bone hypoplasia (HP:0001498)2.43411487
51Chromsome breakage (HP:0040012)2.42382333
52Horseshoe kidney (HP:0000085)2.40816649
53Optic disc pallor (HP:0000543)2.39852298
54Stenosis of the external auditory canal (HP:0000402)2.38381456
55Abnormality of the ileum (HP:0001549)2.36816482
56Abnormality of the labia minora (HP:0012880)2.31785451
57Hypoplasia of the ulna (HP:0003022)2.29705895
58Hypoplastic labia majora (HP:0000059)2.28119927
59Cerebral edema (HP:0002181)2.27518836
60Macrocytic anemia (HP:0001972)2.25962943
61Meckel diverticulum (HP:0002245)2.22718112
62Cutaneous finger syndactyly (HP:0010554)2.20910983
63Zonular cataract (HP:0010920)2.18006875
64Mixed hearing impairment (HP:0000410)2.17781970
65Anal stenosis (HP:0002025)2.11320401
66Short thumb (HP:0009778)2.10604905
67Aplasia/Hypoplasia of the ulna (HP:0006495)2.08268872
68Septo-optic dysplasia (HP:0100842)2.07962106
69Chronic sinusitis (HP:0011109)2.05591435
70Abnormality of the phalanges of the 2nd finger (HP:0009541)2.05465913
71Congenital, generalized hypertrichosis (HP:0004540)2.05066695
72Abnormality of the labia majora (HP:0012881)2.03673011
73Bilateral microphthalmos (HP:0007633)1.99256833
74Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98700341
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98700341
76Leukodystrophy (HP:0002415)1.97615643
77Abnormality of the duodenum (HP:0002246)1.96841958
78Optic nerve hypoplasia (HP:0000609)1.95938553
79Growth hormone deficiency (HP:0000824)1.94482111
80Attenuation of retinal blood vessels (HP:0007843)1.93226929
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90278002
82Pancreatic fibrosis (HP:0100732)1.88178764
83Maternal diabetes (HP:0009800)1.86726340
84Deep palmar crease (HP:0006191)1.85175839
85Volvulus (HP:0002580)1.83630337
86Absent hair (HP:0002298)1.82974100
87Albinism (HP:0001022)1.80913313
88Cutaneous syndactyly (HP:0012725)1.80757334
89Renal agenesis (HP:0000104)1.80201291
90Anterior segment dysgenesis (HP:0007700)1.79708949
913-Methylglutaconic aciduria (HP:0003535)1.79309228
92Abnormality of midbrain morphology (HP:0002418)1.78353327
93Molar tooth sign on MRI (HP:0002419)1.78353327
94Abnormality of the pons (HP:0007361)1.77678686
95True hermaphroditism (HP:0010459)1.75131502
96Concave nail (HP:0001598)1.72258204
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.71525864
98Hypoplasia of the pons (HP:0012110)1.68547951
99Aplasia/hypoplasia of the humerus (HP:0006507)1.66348371
100Bony spicule pigmentary retinopathy (HP:0007737)1.65910963

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK25.26325862
2CDK194.35269542
3VRK24.01833567
4ERBB43.73854174
5WNK33.67889855
6NEK23.03679348
7FLT32.81793658
8BRD42.81199927
9BMPR1B2.65808209
10TLK12.60727531
11ZAK2.57892853
12MAP4K22.51776440
13VRK12.46576682
14STK162.30349904
15FRK1.82628387
16PASK1.72570413
17GRK11.59336037
18BRSK21.55038413
19OXSR11.52008773
20TNIK1.49843291
21PRKD31.45827235
22NUAK11.44930161
23TGFBR11.43496911
24ACVR1B1.41233632
25MARK31.38982203
26PLK21.37761122
27PINK11.26476764
28KIT1.19307651
29BMPR21.19153099
30MAP3K61.11848324
31DYRK21.09176128
32DAPK31.08515795
33BCKDK1.08372858
34GRK71.03692226
35MAP3K91.02146379
36PIK3CG0.99493908
37STK40.98616741
38NEK10.96984295
39MAP3K120.96300297
40CHEK20.94830247
41CASK0.92056430
42BUB10.81967626
43PLK30.81881308
44CDC70.80987396
45TAF10.79405159
46MAP4K10.75264715
47ADRBK20.75175434
48PRKCE0.73388650
49OBSCN0.69863224
50BRSK10.65201672
51DAPK10.63297605
52MAPK130.61427175
53PKN10.61144824
54ABL20.58183761
55SIK30.56723076
56ADRBK10.56214986
57CHUK0.55274216
58MAP2K70.54056468
59MATK0.53377261
60RPS6KA50.53038088
61SRPK10.52431748
62NME10.49887149
63AURKB0.47773567
64ERBB30.42399177
65RPS6KA40.42109114
66PHKG20.40874465
67PHKG10.40874465
68CDK70.40189253
69PKN20.39913906
70PRKCI0.39629262
71NTRK30.38554512
72MAP3K130.37897751
73INSRR0.35892268
74MARK10.35340104
75PRKCG0.35012461
76CSNK1A10.34378602
77CSF1R0.32188099
78MST40.31843042
79MAP2K60.30888101
80TXK0.30438470
81BCR0.30374756
82PLK10.28576065
83MYLK0.28062796
84IKBKB0.27508203
85FGFR20.26999380
86LYN0.25783242
87PRKG10.25505621
88MINK10.23789680
89TAOK30.23551888
90CSNK2A10.23323723
91AURKA0.22457954
92WNK40.21938456
93SYK0.21046899
94CSNK2A20.19499690
95PRKACB0.19062520
96TTK0.19019141
97IGF1R0.18395342
98IRAK10.17749521
99PAK10.15586835
100CDK50.14916295

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.60175984
2Oxidative phosphorylation_Homo sapiens_hsa001904.26460976
3Proteasome_Homo sapiens_hsa030504.09225516
4Parkinsons disease_Homo sapiens_hsa050123.65019754
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.36686975
6Protein export_Homo sapiens_hsa030602.99018863
7Asthma_Homo sapiens_hsa053102.63906091
8Huntingtons disease_Homo sapiens_hsa050162.55371503
9RNA polymerase_Homo sapiens_hsa030202.48330187
10Alzheimers disease_Homo sapiens_hsa050102.32697605
11Systemic lupus erythematosus_Homo sapiens_hsa053222.22714400
12Fanconi anemia pathway_Homo sapiens_hsa034601.98134344
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95895905
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70177299
15Cardiac muscle contraction_Homo sapiens_hsa042601.66730972
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63270126
17RNA degradation_Homo sapiens_hsa030181.55612601
18Homologous recombination_Homo sapiens_hsa034401.55311580
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51574850
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50455829
21Taste transduction_Homo sapiens_hsa047421.50451075
22Allograft rejection_Homo sapiens_hsa053301.44823701
23Alcoholism_Homo sapiens_hsa050341.40980598
24Nitrogen metabolism_Homo sapiens_hsa009101.39681604
25Autoimmune thyroid disease_Homo sapiens_hsa053201.38757365
26Nicotine addiction_Homo sapiens_hsa050331.36231129
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30828288
28Caffeine metabolism_Homo sapiens_hsa002321.27960021
29Type I diabetes mellitus_Homo sapiens_hsa049401.23844139
30Phototransduction_Homo sapiens_hsa047441.22418987
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.21820253
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.21473912
33Mismatch repair_Homo sapiens_hsa034301.11803036
34Graft-versus-host disease_Homo sapiens_hsa053321.08000821
35Peroxisome_Homo sapiens_hsa041461.06075702
36Nucleotide excision repair_Homo sapiens_hsa034200.98230229
37Spliceosome_Homo sapiens_hsa030400.95920740
38Purine metabolism_Homo sapiens_hsa002300.90487262
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88442602
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87505990
41Basal transcription factors_Homo sapiens_hsa030220.87463587
42Butanoate metabolism_Homo sapiens_hsa006500.86967129
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.85891073
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85310360
45One carbon pool by folate_Homo sapiens_hsa006700.84542460
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84170466
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83089638
48Selenocompound metabolism_Homo sapiens_hsa004500.80992741
49Biosynthesis of amino acids_Homo sapiens_hsa012300.78687907
50Pyrimidine metabolism_Homo sapiens_hsa002400.77198388
51DNA replication_Homo sapiens_hsa030300.75799763
52TGF-beta signaling pathway_Homo sapiens_hsa043500.75341512
53Non-homologous end-joining_Homo sapiens_hsa034500.75010786
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73533012
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73341717
56Pyruvate metabolism_Homo sapiens_hsa006200.70139201
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70098886
58Olfactory transduction_Homo sapiens_hsa047400.69445382
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68842826
60Tryptophan metabolism_Homo sapiens_hsa003800.66623940
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65496679
62RNA transport_Homo sapiens_hsa030130.63528013
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62209334
64Collecting duct acid secretion_Homo sapiens_hsa049660.61375990
65Calcium signaling pathway_Homo sapiens_hsa040200.59799752
66Basal cell carcinoma_Homo sapiens_hsa052170.59642623
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59296687
68mRNA surveillance pathway_Homo sapiens_hsa030150.54577017
69Rheumatoid arthritis_Homo sapiens_hsa053230.53173549
70Metabolic pathways_Homo sapiens_hsa011000.52061440
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50198603
72Retinol metabolism_Homo sapiens_hsa008300.49154740
73Circadian entrainment_Homo sapiens_hsa047130.48856379
74Dopaminergic synapse_Homo sapiens_hsa047280.48380865
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44420412
76Regulation of autophagy_Homo sapiens_hsa041400.44083920
77Cocaine addiction_Homo sapiens_hsa050300.42564756
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42107320
79Carbon metabolism_Homo sapiens_hsa012000.41184508
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40903740
81Base excision repair_Homo sapiens_hsa034100.38436837
82Pentose phosphate pathway_Homo sapiens_hsa000300.38098846
83Arachidonic acid metabolism_Homo sapiens_hsa005900.37405322
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36337390
85Hedgehog signaling pathway_Homo sapiens_hsa043400.35300531
86Leishmaniasis_Homo sapiens_hsa051400.34310602
87Glutathione metabolism_Homo sapiens_hsa004800.33498371
88Chemical carcinogenesis_Homo sapiens_hsa052040.32928391
89Propanoate metabolism_Homo sapiens_hsa006400.32843620
90GABAergic synapse_Homo sapiens_hsa047270.29562236
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27904244
92N-Glycan biosynthesis_Homo sapiens_hsa005100.27504448
93Serotonergic synapse_Homo sapiens_hsa047260.25714771
94Morphine addiction_Homo sapiens_hsa050320.25683205
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24869947
96Primary immunodeficiency_Homo sapiens_hsa053400.24426491
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24165778
98Linoleic acid metabolism_Homo sapiens_hsa005910.23028689
99Antigen processing and presentation_Homo sapiens_hsa046120.21349205
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21252476

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