ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.36138677
2	response to pheromone (GO:0019236)	4.15435709
3	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.88676267
4	protein K11-linked deubiquitination (GO:0035871)	3.77177189
5	limb bud formation (GO:0060174)	3.71524111
6	neural tube formation (GO:0001841)	3.64789966
7	detection of light stimulus involved in visual perception (GO:0050908)	3.63602725
8	detection of light stimulus involved in sensory perception (GO:0050962)	3.63602725
9	L-fucose catabolic process (GO:0042355)	3.60929638
10	fucose catabolic process (GO:0019317)	3.60929638
11	L-fucose metabolic process (GO:0042354)	3.60929638
12	DNA double-strand break processing (GO:0000729)	3.51505281
13	platelet dense granule organization (GO:0060155)	3.50842795
14	cornea development in camera-type eye (GO:0061303)	3.41082707
15	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.35314248
16	regulation of cilium movement (GO:0003352)	3.34960721
17	C4-dicarboxylate transport (GO:0015740)	3.31084249
18	behavioral response to ethanol (GO:0048149)	3.29119107
19	hindbrain development (GO:0030902)	3.25106862
20	nonmotile primary cilium assembly (GO:0035058)	3.17034710
21	atrial cardiac muscle cell action potential (GO:0086014)	3.15451149
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13189611
23	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13189611
24	NADH dehydrogenase complex assembly (GO:0010257)	3.13189611
25	glycerophospholipid catabolic process (GO:0046475)	3.08262672
26	retinal cone cell development (GO:0046549)	3.02404721
27	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.02394078
28	protein localization to cilium (GO:0061512)	3.01451779
29	regulation of meiosis I (GO:0060631)	3.00132596
30	axoneme assembly (GO:0035082)	2.98654517
31	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.98276689
32	cilium morphogenesis (GO:0060271)	2.95413333
33	piRNA metabolic process (GO:0034587)	2.94038967
34	protein complex biogenesis (GO:0070271)	2.93773830
35	reflex (GO:0060004)	2.91391227
36	indolalkylamine metabolic process (GO:0006586)	2.90676872
37	regulation of hippo signaling (GO:0035330)	2.90191401
38	transmission of nerve impulse (GO:0019226)	2.89090088
39	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.88013418
40	gamma-aminobutyric acid transport (GO:0015812)	2.87194897
41	photoreceptor cell maintenance (GO:0045494)	2.86827904
42	replication fork processing (GO:0031297)	2.82470793
43	tryptophan catabolic process (GO:0006569)	2.81780136
44	indole-containing compound catabolic process (GO:0042436)	2.81780136
45	indolalkylamine catabolic process (GO:0046218)	2.81780136
46	negative regulation of telomere maintenance (GO:0032205)	2.80421432
47	epithelial cilium movement (GO:0003351)	2.79805231
48	protein polyglutamylation (GO:0018095)	2.77801738
49	inner ear receptor stereocilium organization (GO:0060122)	2.76754079
50	cilium organization (GO:0044782)	2.74766232
51	sympathetic nervous system development (GO:0048485)	2.73373331
52	regulation of hexokinase activity (GO:1903299)	2.73201314
53	regulation of glucokinase activity (GO:0033131)	2.73201314
54	water-soluble vitamin biosynthetic process (GO:0042364)	2.71959772
55	pyrimidine nucleobase catabolic process (GO:0006208)	2.71437142
56	respiratory chain complex IV assembly (GO:0008535)	2.70377569
57	proline transport (GO:0015824)	2.69835380
58	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.69764922
59	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.69764922
60	regulation of translation, ncRNA-mediated (GO:0045974)	2.69764922
61	protein-cofactor linkage (GO:0018065)	2.68452644
62	cilium assembly (GO:0042384)	2.68177074
63	presynaptic membrane assembly (GO:0097105)	2.66345221
64	mitochondrial respiratory chain complex assembly (GO:0033108)	2.66313599
65	somite development (GO:0061053)	2.65810704
66	auditory receptor cell stereocilium organization (GO:0060088)	2.64144517
67	kidney morphogenesis (GO:0060993)	2.63722659
68	male meiosis (GO:0007140)	2.62097623
69	nucleobase catabolic process (GO:0046113)	2.61322771
70	regulation of telomere maintenance (GO:0032204)	2.59272258
71	intraciliary transport (GO:0042073)	2.57094869
72	glial cell proliferation (GO:0014009)	2.55781305
73	glycosphingolipid biosynthetic process (GO:0006688)	2.55269099
74	kynurenine metabolic process (GO:0070189)	2.54791872
75	photoreceptor cell development (GO:0042461)	2.54361598
76	dopamine transport (GO:0015872)	2.52479841
77	neuronal action potential (GO:0019228)	2.52099543
78	keratinocyte development (GO:0003334)	2.51793148
79	cellular ketone body metabolic process (GO:0046950)	2.51764645
80	prenylation (GO:0097354)	2.51383620
81	protein prenylation (GO:0018342)	2.51383620
82	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.49566730
83	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.49326157
84	recombinational repair (GO:0000725)	2.48806985
85	regulation of neurotransmitter uptake (GO:0051580)	2.48724104
86	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.48603294
87	neuronal action potential propagation (GO:0019227)	2.48084644
88	double-strand break repair via homologous recombination (GO:0000724)	2.47709061
89	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.46565008
90	regulation of collateral sprouting (GO:0048670)	2.45998205
91	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.45670436
92	embryonic epithelial tube formation (GO:0001838)	2.44285881
93	positive regulation of meiosis (GO:0045836)	2.44272002
94	centriole replication (GO:0007099)	2.42769942
95	DNA deamination (GO:0045006)	2.42578555
96	rhodopsin mediated signaling pathway (GO:0016056)	2.42252557
97	regulation of DNA endoreduplication (GO:0032875)	2.40333901
98	tachykinin receptor signaling pathway (GO:0007217)	2.40292772
99	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.39142593
100	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.38016407

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.44336948
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.27333280
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.91622971
4	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.83967439
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.69544317
6	VDR_22108803_ChIP-Seq_LS180_Human	2.67813136
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.60696900
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.55932571
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.51656021
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35838585
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.34454516
12	EWS_26573619_Chip-Seq_HEK293_Human	2.33858188
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.32772405
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.30880866
15	FUS_26573619_Chip-Seq_HEK293_Human	2.21771418
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.18719896
17	P300_19829295_ChIP-Seq_ESCs_Human	2.16733384
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14558569
19	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.14305808
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.94841955
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.83906987
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83706815
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.79230721
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.77735186
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72591267
26	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.72500600
27	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.72264693
28	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69386166
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.64289956
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64289956
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.60659515
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.60352787
33	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.60104829
34	AR_25329375_ChIP-Seq_VCAP_Human	1.58686303
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58396326
36	STAT3_23295773_ChIP-Seq_U87_Human	1.57508162
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55587746
38	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53599425
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.52885837
40	TCF4_23295773_ChIP-Seq_U87_Human	1.51909968
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.49664986
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48526674
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.47912026
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.45190196
45	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.45048855
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.44875981
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44709385
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38901845
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.38091074
50	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37377698
51	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.36630205
52	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.36384763
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36375849
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.35807928
55	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.34805154
56	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.33103802
57	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.32681803
58	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.30830282
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29249846
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27363505
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27363505
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.27053825
63	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27053825
64	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.26692039
65	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.26162371
66	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26059220
67	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.25427436
68	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.24559343
69	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.24013670
70	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23768072
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.23344156
72	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22598207
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.21987838
74	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.21538935
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.20246389
76	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17453670
77	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.17330838
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.16933726
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.13520915
80	REST_21632747_ChIP-Seq_MESCs_Mouse	1.12621807
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.12489148
82	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11307459
83	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.11199437
84	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.11092676
85	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.10805698
86	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.10185735
87	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.08876001
88	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07654153
89	P300_18555785_Chip-Seq_ESCs_Mouse	1.06387730
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06385154
91	ELK1_19687146_ChIP-ChIP_HELA_Human	1.06084955
92	CDX2_22108803_ChIP-Seq_LS180_Human	1.05850895
93	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05522568
94	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05499126
95	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04221049
96	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03927770
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.02779674
98	TP53_16413492_ChIP-PET_HCT116_Human	1.02035593
99	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.98961810
100	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.98517088

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	3.41624542
2	MP0003195_calcinosis	3.28215185
3	MP0005551_abnormal_eye_electrophysiolog	2.76825462
4	MP0001968_abnormal_touch/_nociception	2.69602512
5	MP0008877_abnormal_DNA_methylation	2.62556938
6	MP0003880_abnormal_central_pattern	2.46352784
7	MP0002102_abnormal_ear_morphology	2.45168681
8	MP0003787_abnormal_imprinting	2.43313344
9	MP0002736_abnormal_nociception_after	2.43286807
10	MP0009046_muscle_twitch	2.37701577
11	MP0005645_abnormal_hypothalamus_physiol	2.37440685
12	MP0005646_abnormal_pituitary_gland	2.10814281
13	MP0009745_abnormal_behavioral_response	2.09034561
14	MP0000372_irregular_coat_pigmentation	1.99360279
15	MP0008872_abnormal_physiological_respon	1.98370819
16	MP0002837_dystrophic_cardiac_calcinosis	1.91963649
17	MP0006072_abnormal_retinal_apoptosis	1.91947501
18	MP0005253_abnormal_eye_physiology	1.89519983
19	MP0003646_muscle_fatigue	1.84887148
20	MP0002876_abnormal_thyroid_physiology	1.84767798
21	MP0002272_abnormal_nervous_system	1.84610335
22	MP0004043_abnormal_pH_regulation	1.84448813
23	MP0002234_abnormal_pharynx_morphology	1.83544732
24	MP0000427_abnormal_hair_cycle	1.74391584
25	MP0001501_abnormal_sleep_pattern	1.60570229
26	MP0004147_increased_porphyrin_level	1.58297028
27	MP0006276_abnormal_autonomic_nervous	1.57296145
28	MP0001486_abnormal_startle_reflex	1.56700568
29	MP0001529_abnormal_vocalization	1.56580962
30	MP0006292_abnormal_olfactory_placode	1.55154502
31	MP0002938_white_spotting	1.55032496
32	MP0000631_abnormal_neuroendocrine_gland	1.54053297
33	MP0001984_abnormal_olfaction	1.49486665
34	MP0002735_abnormal_chemical_nociception	1.48494458
35	MP0002064_seizures	1.46980218
36	MP0005174_abnormal_tail_pigmentation	1.39165248
37	MP0004133_heterotaxia	1.37781597
38	MP0002751_abnormal_autonomic_nervous	1.37215196
39	MP0000647_abnormal_sebaceous_gland	1.36295477
40	MP0004924_abnormal_behavior	1.35496101
41	MP0005386_behavior/neurological_phenoty	1.35496101
42	MP0002653_abnormal_ependyma_morphology	1.35250802
43	MP0001986_abnormal_taste_sensitivity	1.35157518
44	MP0002638_abnormal_pupillary_reflex	1.34423768
45	MP0004885_abnormal_endolymph	1.34294256
46	MP0005084_abnormal_gallbladder_morpholo	1.31023560
47	MP0008058_abnormal_DNA_repair	1.30345015
48	MP0002572_abnormal_emotion/affect_behav	1.28695064
49	MP0002557_abnormal_social/conspecific_i	1.27934945
50	MP0002734_abnormal_mechanical_nocicepti	1.27658337
51	MP0005379_endocrine/exocrine_gland_phen	1.27652086
52	MP0000778_abnormal_nervous_system	1.24746870
53	MP0008789_abnormal_olfactory_epithelium	1.24136528
54	MP0001970_abnormal_pain_threshold	1.22944356
55	MP0002163_abnormal_gland_morphology	1.22578192
56	MP0003121_genomic_imprinting	1.22051123
57	MP0008875_abnormal_xenobiotic_pharmacok	1.22049291
58	MP0001485_abnormal_pinna_reflex	1.21175679
59	MP0003635_abnormal_synaptic_transmissio	1.19169800
60	MP0002733_abnormal_thermal_nociception	1.14708529
61	MP0001764_abnormal_homeostasis	1.14549780
62	MP0004142_abnormal_muscle_tone	1.13083418
63	MP0002095_abnormal_skin_pigmentation	1.08513277
64	MP0003718_maternal_effect	1.07884658
65	MP0002063_abnormal_learning/memory/cond	1.06271604
66	MP0005195_abnormal_posterior_eye	1.05339016
67	MP0002067_abnormal_sensory_capabilities	1.03023225
68	MP0005389_reproductive_system_phenotype	1.01692409
69	MP0009780_abnormal_chondrocyte_physiolo	0.98389135
70	MP0003136_yellow_coat_color	0.97247861
71	MP0003950_abnormal_plasma_membrane	0.96906614
72	MP0001324_abnormal_eye_pigmentation	0.96394325
73	MP0001919_abnormal_reproductive_system	0.95976512
74	MP0002184_abnormal_innervation	0.95781456
75	MP0005075_abnormal_melanosome_morpholog	0.94474855
76	MP0008775_abnormal_heart_ventricle	0.93485089
77	MP0004215_abnormal_myocardial_fiber	0.93403398
78	MP0005187_abnormal_penis_morphology	0.92781283
79	MP0002160_abnormal_reproductive_system	0.92357785
80	MP0005410_abnormal_fertilization	0.91485417
81	MP0002752_abnormal_somatic_nervous	0.91347776
82	MP0004145_abnormal_muscle_electrophysio	0.91118486
83	MP0002909_abnormal_adrenal_gland	0.90852668
84	MP0004270_analgesia	0.90230334
85	MP0003698_abnormal_male_reproductive	0.88714196
86	MP0000015_abnormal_ear_pigmentation	0.85642882
87	MP0002090_abnormal_vision	0.84540243
88	MP0003122_maternal_imprinting	0.84470269
89	MP0001929_abnormal_gametogenesis	0.83712300
90	MP0010386_abnormal_urinary_bladder	0.80375214
91	MP0004742_abnormal_vestibular_system	0.79143586
92	MP0003137_abnormal_impulse_conducting	0.78467021
93	MP0003890_abnormal_embryonic-extraembry	0.77900351
94	MP0005367_renal/urinary_system_phenotyp	0.77331018
95	MP0000516_abnormal_urinary_system	0.77331018
96	MP0000230_abnormal_systemic_arterial	0.77207413
97	MP0002210_abnormal_sex_determination	0.77203903
98	MP0005499_abnormal_olfactory_system	0.76215067
99	MP0005394_taste/olfaction_phenotype	0.76215067
100	MP0002229_neurodegeneration	0.74518754

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.42197283
2	Hyperventilation (HP:0002883)	4.07374015
3	Molar tooth sign on MRI (HP:0002419)	3.86112681
4	Abnormality of midbrain morphology (HP:0002418)	3.86112681
5	Pancreatic fibrosis (HP:0100732)	3.82899221
6	True hermaphroditism (HP:0010459)	3.81791217
7	Congenital stationary night blindness (HP:0007642)	3.65216421
8	Nephronophthisis (HP:0000090)	3.32154798
9	Abnormality of the labia minora (HP:0012880)	3.04536104
10	Medial flaring of the eyebrow (HP:0010747)	3.00994203
11	Abnormality of the renal medulla (HP:0100957)	2.99622219
12	Abnormality of the renal cortex (HP:0011035)	2.86519669
13	Type II lissencephaly (HP:0007260)	2.83916141
14	Inability to walk (HP:0002540)	2.77540133
15	Intestinal atresia (HP:0011100)	2.71898094
16	Focal motor seizures (HP:0011153)	2.70412161
17	Chronic hepatic failure (HP:0100626)	2.67619049
18	Fair hair (HP:0002286)	2.65036708
19	Attenuation of retinal blood vessels (HP:0007843)	2.64015866
20	Absent speech (HP:0001344)	2.63349151
21	Cystic liver disease (HP:0006706)	2.63243515
22	Broad-based gait (HP:0002136)	2.57912604
23	Pendular nystagmus (HP:0012043)	2.57331589
24	Abnormal drinking behavior (HP:0030082)	2.54044181
25	Polydipsia (HP:0001959)	2.54044181
26	Gait imbalance (HP:0002141)	2.50206146
27	Progressive inability to walk (HP:0002505)	2.49500612
28	Hypothermia (HP:0002045)	2.48337190
29	Gaze-evoked nystagmus (HP:0000640)	2.47624898
30	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.47210785
31	Congenital primary aphakia (HP:0007707)	2.44936180
32	Febrile seizures (HP:0002373)	2.42392351
33	Tubular atrophy (HP:0000092)	2.41917660
34	Abolished electroretinogram (ERG) (HP:0000550)	2.41143657
35	Hypoproteinemia (HP:0003075)	2.38458451
36	Volvulus (HP:0002580)	2.32627326
37	Lissencephaly (HP:0001339)	2.31500186
38	Genital tract atresia (HP:0001827)	2.28401288
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.26755587
40	Keratoconus (HP:0000563)	2.26143353
41	Increased corneal curvature (HP:0100692)	2.26143353
42	Nephrogenic diabetes insipidus (HP:0009806)	2.23730162
43	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.12614321
44	Sclerocornea (HP:0000647)	2.12355084
45	Protruding tongue (HP:0010808)	2.11951087
46	Vaginal atresia (HP:0000148)	2.10602344
47	Polyuria (HP:0000103)	2.07919224
48	Anencephaly (HP:0002323)	2.06023088
49	Generalized hypopigmentation of hair (HP:0011358)	2.05746959
50	Congenital sensorineural hearing impairment (HP:0008527)	2.04311058
51	Drooling (HP:0002307)	2.03901395
52	Abnormality of macular pigmentation (HP:0008002)	2.02952667
53	Focal seizures (HP:0007359)	2.02483335
54	Hypomagnesemia (HP:0002917)	2.02250717
55	Hypoplasia of the fovea (HP:0007750)	2.01984915
56	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.01984915
57	Renal cortical cysts (HP:0000803)	2.00541636
58	Dialeptic seizures (HP:0011146)	1.99357391
59	Male pseudohermaphroditism (HP:0000037)	1.97857161
60	Postaxial foot polydactyly (HP:0001830)	1.97307046
61	Optic nerve hypoplasia (HP:0000609)	1.95291151
62	Congenital hepatic fibrosis (HP:0002612)	1.94354083
63	Pachygyria (HP:0001302)	1.94222112
64	Large for gestational age (HP:0001520)	1.94159853
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.93653980
66	Chorioretinal atrophy (HP:0000533)	1.93272467
67	Atonic seizures (HP:0010819)	1.92842989
68	Ketoacidosis (HP:0001993)	1.92526329
69	Furrowed tongue (HP:0000221)	1.91151569
70	Gastrointestinal atresia (HP:0002589)	1.90957949
71	Stomach cancer (HP:0012126)	1.90680431
72	Cerebellar dysplasia (HP:0007033)	1.90025297
73	Progressive cerebellar ataxia (HP:0002073)	1.89580567
74	Hemiparesis (HP:0001269)	1.89383183
75	Thyroiditis (HP:0100646)	1.88001305
76	Postaxial hand polydactyly (HP:0001162)	1.87219707
77	Widely spaced teeth (HP:0000687)	1.86473812
78	Albinism (HP:0001022)	1.86058859
79	Poor coordination (HP:0002370)	1.83495792
80	Bile duct proliferation (HP:0001408)	1.82015737
81	Abnormal biliary tract physiology (HP:0012439)	1.82015737
82	Absent/shortened dynein arms (HP:0200106)	1.81593359
83	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81593359
84	Excessive salivation (HP:0003781)	1.80989252
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79797936
86	Abnormality of alanine metabolism (HP:0010916)	1.79797936
87	Hyperalaninemia (HP:0003348)	1.79797936
88	Decreased central vision (HP:0007663)	1.79770067
89	Increased CSF lactate (HP:0002490)	1.78734182
90	3-Methylglutaconic aciduria (HP:0003535)	1.78675886
91	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.78347730
92	Abnormal protein N-linked glycosylation (HP:0012347)	1.78347730
93	Abnormal protein glycosylation (HP:0012346)	1.78347730
94	Abnormal glycosylation (HP:0012345)	1.78347730
95	Narrow forehead (HP:0000341)	1.78242862
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.78210118
97	Astigmatism (HP:0000483)	1.76867534
98	Progressive macrocephaly (HP:0004481)	1.76516459
99	Acute necrotizing encephalopathy (HP:0006965)	1.74159581
100	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.72716640

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.32268078
2	MAP4K2	3.31733831
3	WNK3	3.08435852
4	CASK	2.93023641
5	INSRR	2.43076725
6	NUAK1	2.35263983
7	ADRBK2	2.31720522
8	TNIK	2.30158687
9	ZAK	2.27983312
10	GRK1	2.25366451
11	MAPK13	2.20181084
12	STK39	2.19262726
13	EIF2AK3	1.99039269
14	NTRK3	1.97937285
15	TRIM28	1.86152077
16	WNK4	1.81231594
17	EPHA4	1.77873099
18	BMPR1B	1.67410248
19	MARK1	1.67393066
20	PINK1	1.63275985
21	PNCK	1.62010826
22	OXSR1	1.60973736
23	MAP3K4	1.50765144
24	TLK1	1.44782812
25	BCR	1.44047044
26	ERBB3	1.43770106
27	ACVR1B	1.39326335
28	PLK2	1.32450991
29	MKNK2	1.28072227
30	PAK3	1.24752702
31	BRSK2	1.23394038
32	STK38L	1.18715546
33	WEE1	1.09076174
34	PRKCE	1.07748423
35	TIE1	1.03739078
36	MAP2K6	1.00174212
37	NEK1	0.98585004
38	TAOK3	0.97543708
39	CAMKK2	0.94167634
40	CSNK1G1	0.93100658
41	DYRK2	0.89154345
42	CSNK1G2	0.87651688
43	VRK1	0.87377355
44	PRKCG	0.86154609
45	DAPK2	0.83394433
46	MST4	0.83087981
47	CSNK1G3	0.81829020
48	LATS1	0.81444020
49	PLK3	0.77874877
50	VRK2	0.74789243
51	STK3	0.73213968
52	MAP2K7	0.73107994
53	PLK4	0.70284081
54	NLK	0.68719836
55	PKN1	0.67687267
56	ADRBK1	0.65918665
57	SIK2	0.65000837
58	IRAK1	0.64585099
59	EIF2AK1	0.64005140
60	PHKG2	0.63833153
61	PHKG1	0.63833153
62	CSNK1A1L	0.62301798
63	MARK3	0.61486928
64	AKT3	0.61046040
65	FER	0.57430186
66	FGFR2	0.57100917
67	TXK	0.56675718
68	SIK3	0.56511904
69	PTK2B	0.55515416
70	CAMK2A	0.53332505
71	TAF1	0.52797661
72	MAPKAPK3	0.51649337
73	PDK2	0.50044047
74	CAMK4	0.49743533
75	SGK2	0.49495569
76	CSNK1A1	0.47650113
77	MKNK1	0.46876453
78	RPS6KA4	0.45324935
79	CAMK1	0.44574470
80	PIK3CA	0.43707084
81	PRKCZ	0.41506647
82	MAPKAPK5	0.40071929
83	DYRK3	0.38080349
84	ATM	0.37975413
85	CDK3	0.37564324
86	CAMK1G	0.36286950
87	PRKACA	0.35836620
88	DYRK1A	0.34843820
89	MINK1	0.33417782
90	CSNK1D	0.32974538
91	TGFBR1	0.32448164
92	STK11	0.31746526
93	PRKG1	0.31381318
94	YES1	0.30581109
95	TSSK6	0.29586351
96	KSR1	0.28946502
97	PLK1	0.28730290
98	RPS6KA5	0.27939422
99	CSNK1E	0.26693266
100	MUSK	0.26230182

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.16091408
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.53444941
3	Protein export_Homo sapiens_hsa03060	2.43222005
4	Butanoate metabolism_Homo sapiens_hsa00650	2.41014445
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.34511516
6	Nitrogen metabolism_Homo sapiens_hsa00910	2.27972530
7	Nicotine addiction_Homo sapiens_hsa05033	2.21916479
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.17333900
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15753336
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.15438923
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.06226698
12	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.05278045
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99257996
14	Basal transcription factors_Homo sapiens_hsa03022	1.98643836
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.97603045
16	Propanoate metabolism_Homo sapiens_hsa00640	1.81683299
17	Ether lipid metabolism_Homo sapiens_hsa00565	1.78106690
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.76364829
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75179148
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.74026981
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72218319
22	RNA polymerase_Homo sapiens_hsa03020	1.71955979
23	Regulation of autophagy_Homo sapiens_hsa04140	1.67298962
24	Homologous recombination_Homo sapiens_hsa03440	1.66264049
25	Non-homologous end-joining_Homo sapiens_hsa03450	1.57021802
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.55505300
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.47515502
28	Taste transduction_Homo sapiens_hsa04742	1.45737026
29	Oxidative phosphorylation_Homo sapiens_hsa00190	1.44938255
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38914686
31	Olfactory transduction_Homo sapiens_hsa04740	1.36740853
32	RNA degradation_Homo sapiens_hsa03018	1.28826862
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.28167059
34	Morphine addiction_Homo sapiens_hsa05032	1.24360330
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.23295288
36	Circadian entrainment_Homo sapiens_hsa04713	1.23215521
37	Circadian rhythm_Homo sapiens_hsa04710	1.21782571
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20432726
39	Caffeine metabolism_Homo sapiens_hsa00232	1.17225493
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.16267065
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.16071821
42	Insulin secretion_Homo sapiens_hsa04911	1.13713283
43	Glutamatergic synapse_Homo sapiens_hsa04724	1.12808923
44	GABAergic synapse_Homo sapiens_hsa04727	1.09956450
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.03987321
46	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.00443207
47	Fatty acid elongation_Homo sapiens_hsa00062	0.99405235
48	Peroxisome_Homo sapiens_hsa04146	0.97358463
49	Serotonergic synapse_Homo sapiens_hsa04726	0.96323633
50	ABC transporters_Homo sapiens_hsa02010	0.92255338
51	Parkinsons disease_Homo sapiens_hsa05012	0.92080624
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91170491
53	Retinol metabolism_Homo sapiens_hsa00830	0.88764528
54	Salivary secretion_Homo sapiens_hsa04970	0.87598330
55	Proteasome_Homo sapiens_hsa03050	0.86322051
56	Steroid biosynthesis_Homo sapiens_hsa00100	0.78494582
57	One carbon pool by folate_Homo sapiens_hsa00670	0.77722511
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.72227834
59	Long-term depression_Homo sapiens_hsa04730	0.72195642
60	Sulfur metabolism_Homo sapiens_hsa00920	0.70558510
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70095049
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.69920681
63	Glycerolipid metabolism_Homo sapiens_hsa00561	0.69530458
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69230168
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.68970659
66	Amphetamine addiction_Homo sapiens_hsa05031	0.68804702
67	Huntingtons disease_Homo sapiens_hsa05016	0.68561051
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.68438743
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.63091280
70	Purine metabolism_Homo sapiens_hsa00230	0.62698646
71	Cocaine addiction_Homo sapiens_hsa05030	0.62083239
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61359205
73	Histidine metabolism_Homo sapiens_hsa00340	0.59557728
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59349440
75	Metabolic pathways_Homo sapiens_hsa01100	0.58998484
76	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.57326461
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57062522
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.56641548
79	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56086282
80	Alzheimers disease_Homo sapiens_hsa05010	0.56072251
81	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55065323
82	Lysine degradation_Homo sapiens_hsa00310	0.54216836
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52868876
84	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.50986602
85	Fatty acid degradation_Homo sapiens_hsa00071	0.50740244
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46947110
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44688110
88	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.44320536
89	Cholinergic synapse_Homo sapiens_hsa04725	0.41378625
90	Pyrimidine metabolism_Homo sapiens_hsa00240	0.39181416
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.38096485
92	Cardiac muscle contraction_Homo sapiens_hsa04260	0.36515803
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.34173791
94	Pancreatic secretion_Homo sapiens_hsa04972	0.33256669
95	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.32593213
96	Renin secretion_Homo sapiens_hsa04924	0.32551762
97	Folate biosynthesis_Homo sapiens_hsa00790	0.32253429
98	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31889867
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.29874229
100	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.29319321

PABPC1P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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