ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	transcription from mitochondrial promoter (GO:0006390)	6.48715194
2	DNA deamination (GO:0045006)	4.87864692
3	pseudouridine synthesis (GO:0001522)	4.25233612
4	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.23456348
5	head development (GO:0060322)	4.20553710
6	rRNA modification (GO:0000154)	4.16758249
7	bone trabecula formation (GO:0060346)	4.14264594
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.12991532
9	rRNA methylation (GO:0031167)	4.02320868
10	signal peptide processing (GO:0006465)	3.93179824
11	detection of light stimulus involved in visual perception (GO:0050908)	3.84805476
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.84805476
13	kidney morphogenesis (GO:0060993)	3.79349358
14	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.69009578
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.60975159
16	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.59948420
17	proteasome assembly (GO:0043248)	3.58700445
18	negative regulation of keratinocyte proliferation (GO:0010839)	3.57928766
19	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.56094640
20	isotype switching (GO:0045190)	3.56094640
21	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.56094640
22	maturation of SSU-rRNA (GO:0030490)	3.51654513
23	multicellular organism reproduction (GO:0032504)	3.48138525
24	regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)	3.46629741
25	positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)	3.46629741
26	chaperone-mediated protein transport (GO:0072321)	3.46182730
27	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.42698972
28	termination of RNA polymerase III transcription (GO:0006386)	3.42698972
29	auditory receptor cell differentiation (GO:0042491)	3.37940891
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34715328
31	piRNA metabolic process (GO:0034587)	3.32876671
32	regulation of immunoglobulin secretion (GO:0051023)	3.31492051
33	mitochondrial RNA metabolic process (GO:0000959)	3.31288776
34	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.30169187
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.26814063
36	ATP synthesis coupled proton transport (GO:0015986)	3.26814063
37	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.22332238
38	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.20999616
39	behavioral response to nicotine (GO:0035095)	3.20693746
40	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.13473226
41	regulation of mitotic spindle checkpoint (GO:1903504)	3.13473226
42	maturation of 5.8S rRNA (GO:0000460)	3.12755546
43	tRNA processing (GO:0008033)	3.10224563
44	protein neddylation (GO:0045116)	3.08980888
45	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.07759712
46	termination of RNA polymerase I transcription (GO:0006363)	3.07217706
47	retinal cone cell development (GO:0046549)	3.05783843
48	transcription from RNA polymerase I promoter (GO:0006360)	3.04263029
49	protein complex biogenesis (GO:0070271)	3.00684499
50	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.97629348
51	regulation of alkaline phosphatase activity (GO:0010692)	2.93590215
52	hair cell differentiation (GO:0035315)	2.92907549
53	GTP biosynthetic process (GO:0006183)	2.91712873
54	mitochondrial respiratory chain complex assembly (GO:0033108)	2.90631620
55	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	2.90243121
56	indolalkylamine metabolic process (GO:0006586)	2.85464679
57	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.85228475
58	regulation of action potential (GO:0098900)	2.84310019
59	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.80845713
60	G-protein coupled receptor internalization (GO:0002031)	2.80767475
61	RNA localization (GO:0006403)	2.80752810
62	positive regulation of prostaglandin secretion (GO:0032308)	2.79655464
63	tRNA metabolic process (GO:0006399)	2.79620204
64	ribosome biogenesis (GO:0042254)	2.74049772
65	single strand break repair (GO:0000012)	2.70756920
66	fucose catabolic process (GO:0019317)	2.70300754
67	L-fucose metabolic process (GO:0042354)	2.70300754
68	L-fucose catabolic process (GO:0042355)	2.70300754
69	somatic diversification of immunoglobulins (GO:0016445)	2.69083823
70	amino acid activation (GO:0043038)	2.68229573
71	tRNA aminoacylation (GO:0043039)	2.68229573
72	central nervous system projection neuron axonogenesis (GO:0021952)	2.68194329
73	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.68038615
74	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.68038615
75	NADH dehydrogenase complex assembly (GO:0010257)	2.68038615
76	regulation of gene silencing by miRNA (GO:0060964)	2.66155752
77	regulation of gene silencing by RNA (GO:0060966)	2.66155752
78	regulation of posttranscriptional gene silencing (GO:0060147)	2.66155752
79	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.65768617
80	7-methylguanosine mRNA capping (GO:0006370)	2.64187440
81	neurotransmitter-gated ion channel clustering (GO:0072578)	2.63918470
82	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.63048961
83	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61723218
84	ncRNA metabolic process (GO:0034660)	2.61612192
85	rRNA processing (GO:0006364)	2.61345315
86	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.61015321
87	translation (GO:0006412)	2.60039024
88	serotonin receptor signaling pathway (GO:0007210)	2.59766208
89	tRNA aminoacylation for protein translation (GO:0006418)	2.59365933
90	rRNA metabolic process (GO:0016072)	2.58604276
91	tRNA modification (GO:0006400)	2.58287779
92	positive regulation of phosphatase activity (GO:0010922)	2.57826737
93	ncRNA catabolic process (GO:0034661)	2.57525550
94	7-methylguanosine RNA capping (GO:0009452)	2.56409887
95	RNA capping (GO:0036260)	2.56409887
96	ncRNA processing (GO:0034470)	2.56193168
97	neuronal action potential (GO:0019228)	2.55986992
98	RNA phosphodiester bond hydrolysis (GO:0090501)	2.54178646
99	interferon-gamma production (GO:0032609)	2.53394843
100	retinal ganglion cell axon guidance (GO:0031290)	2.53205617

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.39032730
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23715556
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.41599445
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.31038440
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.23594264
6	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.92672208
7	VDR_22108803_ChIP-Seq_LS180_Human	2.69532784
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.60202656
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.58021676
10	* EWS_26573619_Chip-Seq_HEK293_Human	2.46813799
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41178242
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37536574
13	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.18858761
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.08576707
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.06192694
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.04948944
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.98677728
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97950602
19	* P300_19829295_ChIP-Seq_ESCs_Human	1.95450533
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.95285819
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.89367489
22	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.86634343
23	EZH2_22144423_ChIP-Seq_EOC_Human	1.82831250
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.81634488
25	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.76965803
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.76162890
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.72408075
28	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.71576136
29	VDR_23849224_ChIP-Seq_CD4+_Human	1.68905601
30	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.67062764
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66420701
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62615996
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61232207
34	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57589508
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.48107305
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46521286
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.44523964
38	FUS_26573619_Chip-Seq_HEK293_Human	1.44453711
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.44017512
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.39965344
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38399022
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38371168
43	AR_21572438_ChIP-Seq_LNCaP_Human	1.38321803
44	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.37268674
45	CBP_20019798_ChIP-Seq_JUKART_Human	1.36031935
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36031935
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.34163283
48	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32241477
49	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31012110
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30945536
51	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.30800065
52	* TCF4_22108803_ChIP-Seq_LS180_Human	1.30709476
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29854493
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27508473
55	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27508473
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.27015358
57	SOX2_19829295_ChIP-Seq_ESCs_Human	1.27015358
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.25435022
59	IGF1R_20145208_ChIP-Seq_DFB_Human	1.21397892
60	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19757506
61	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.18523840
62	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18523840
63	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.18400652
64	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.16991786
65	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.16973830
66	ER_23166858_ChIP-Seq_MCF-7_Human	1.15776729
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14462380
68	TCF4_23295773_ChIP-Seq_U87_Human	1.14271020
69	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.13656429
70	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.13083216
71	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.12124707
72	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.08773660
73	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.08700249
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07272686
75	* TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07000135
76	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05841665
77	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.04863137
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03886649
79	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.03745667
80	STAT3_23295773_ChIP-Seq_U87_Human	1.03510307
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.02845957
82	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02684013
83	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02106114
84	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.01986841
85	* PIAS1_25552417_ChIP-Seq_VCAP_Human	1.01733920
86	* RUNX2_22187159_ChIP-Seq_PCA_Human	0.99951021
87	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.98635140
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.97401494
89	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96677578
90	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.95899679
91	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.95077888
92	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.94986675
93	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.94856137
94	MYC_19829295_ChIP-Seq_ESCs_Human	0.93389358
95	ERG_20517297_ChIP-Seq_VCAP_Human	0.92764529
96	AR_20517297_ChIP-Seq_VCAP_Human	0.92400510
97	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.92384423
98	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.91828270
99	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.91657451
100	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.90670802

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.26429096
2	MP0002234_abnormal_pharynx_morphology	3.75503533
3	MP0005084_abnormal_gallbladder_morpholo	3.57776992
4	MP0006292_abnormal_olfactory_placode	2.85152187
5	MP0003718_maternal_effect	2.84832829
6	MP0005423_abnormal_somatic_nervous	2.82789846
7	MP0003890_abnormal_embryonic-extraembry	2.60442604
8	MP0003567_abnormal_fetal_cardiomyocyte	2.47715801
9	MP0008057_abnormal_DNA_replication	2.38528561
10	MP0008058_abnormal_DNA_repair	2.14693593
11	MP0006035_abnormal_mitochondrial_morpho	2.13658906
12	MP0003119_abnormal_digestive_system	1.98347515
13	MP0001984_abnormal_olfaction	1.92392161
14	MP0005551_abnormal_eye_electrophysiolog	1.91628723
15	MP0001293_anophthalmia	1.82277807
16	MP0002138_abnormal_hepatobiliary_system	1.79989432
17	MP0001968_abnormal_touch/_nociception	1.76760581
18	MP0002736_abnormal_nociception_after	1.76418420
19	MP0004885_abnormal_endolymph	1.73819674
20	MP0003195_calcinosis	1.68200679
21	MP0001501_abnormal_sleep_pattern	1.67012592
22	MP0000631_abnormal_neuroendocrine_gland	1.66785672
23	MP0002254_reproductive_system_inflammat	1.66347758
24	MP0008872_abnormal_physiological_respon	1.64690093
25	MP0005670_abnormal_white_adipose	1.62040256
26	MP0000778_abnormal_nervous_system	1.61502073
27	MP0001485_abnormal_pinna_reflex	1.60330497
28	MP0008775_abnormal_heart_ventricle	1.57768201
29	MP0006276_abnormal_autonomic_nervous	1.56031263
30	MP0008877_abnormal_DNA_methylation	1.53227956
31	MP0005410_abnormal_fertilization	1.49088696
32	MP0002272_abnormal_nervous_system	1.47852080
33	MP0008875_abnormal_xenobiotic_pharmacok	1.44144150
34	MP0002638_abnormal_pupillary_reflex	1.37726305
35	MP0002277_abnormal_respiratory_mucosa	1.33552115
36	MP0002938_white_spotting	1.29404795
37	MP0004085_abnormal_heartbeat	1.28693245
38	MP0004133_heterotaxia	1.25764788
39	MP0003693_abnormal_embryo_hatching	1.25503686
40	MP0009384_cardiac_valve_regurgitation	1.25334139
41	MP0006072_abnormal_retinal_apoptosis	1.19846742
42	MP0002876_abnormal_thyroid_physiology	1.17663965
43	MP0001286_abnormal_eye_development	1.16862486
44	MP0005365_abnormal_bile_salt	1.15811090
45	MP0002184_abnormal_innervation	1.15334075
46	MP0004957_abnormal_blastocyst_morpholog	1.14175584
47	MP0005595_abnormal_vascular_smooth	1.08198059
48	MP0002160_abnormal_reproductive_system	1.08176910
49	MP0004145_abnormal_muscle_electrophysio	1.07164838
50	MP0010234_abnormal_vibrissa_follicle	1.03406841
51	MP0003011_delayed_dark_adaptation	1.02511334
52	MP0004264_abnormal_extraembryonic_tissu	1.01994061
53	MP0004084_abnormal_cardiac_muscle	1.00117603
54	MP0002233_abnormal_nose_morphology	0.99728250
55	MP0009745_abnormal_behavioral_response	0.98300392
56	MP0005389_reproductive_system_phenotype	0.97129225
57	MP0003880_abnormal_central_pattern	0.96725640
58	MP0003137_abnormal_impulse_conducting	0.96336253
59	MP0006036_abnormal_mitochondrial_physio	0.95945731
60	MP0002210_abnormal_sex_determination	0.95607457
61	MP0001529_abnormal_vocalization	0.95046358
62	MP0005645_abnormal_hypothalamus_physiol	0.94819605
63	MP0003878_abnormal_ear_physiology	0.94236522
64	MP0005377_hearing/vestibular/ear_phenot	0.94236522
65	MP0005266_abnormal_metabolism	0.92990615
66	MP0000230_abnormal_systemic_arterial	0.91940088
67	MP0002332_abnormal_exercise_endurance	0.90803609
68	MP0004142_abnormal_muscle_tone	0.89894123
69	MP0005253_abnormal_eye_physiology	0.87651089
70	MP0005395_other_phenotype	0.87547213
71	MP0002928_abnormal_bile_duct	0.87401759
72	MP0001346_abnormal_lacrimal_gland	0.86695147
73	MP0003786_premature_aging	0.83849889
74	MP0008789_abnormal_olfactory_epithelium	0.82933977
75	MP0003936_abnormal_reproductive_system	0.82394873
76	MP0002572_abnormal_emotion/affect_behav	0.79614069
77	MP0003943_abnormal_hepatobiliary_system	0.79125470
78	MP0009046_muscle_twitch	0.78790487
79	MP0005195_abnormal_posterior_eye	0.77706642
80	MP0002734_abnormal_mechanical_nocicepti	0.76476504
81	MP0002752_abnormal_somatic_nervous	0.76230208
82	MP0000685_abnormal_immune_system	0.76102106
83	MP0003303_peritoneal_inflammation	0.75432799
84	MP0008770_decreased_survivor_rate	0.74304893
85	MP0001544_abnormal_cardiovascular_syste	0.73204438
86	MP0005385_cardiovascular_system_phenoty	0.73204438
87	MP0002067_abnormal_sensory_capabilities	0.72850246
88	MP0003787_abnormal_imprinting	0.72033650
89	MP0003635_abnormal_synaptic_transmissio	0.71883709
90	MP0003698_abnormal_male_reproductive	0.71198404
91	MP0001986_abnormal_taste_sensitivity	0.69557423
92	MP0004924_abnormal_behavior	0.69030724
93	MP0005386_behavior/neurological_phenoty	0.69030724
94	MP0001881_abnormal_mammary_gland	0.68464451
95	MP0000049_abnormal_middle_ear	0.67494166
96	MP0005174_abnormal_tail_pigmentation	0.67220316
97	MP0001970_abnormal_pain_threshold	0.66981781
98	MP0002909_abnormal_adrenal_gland	0.66833054
99	MP0004215_abnormal_myocardial_fiber	0.66812826
100	MP0003938_abnormal_ear_development	0.66753050

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.40133228
2	Abnormality of the labia minora (HP:0012880)	4.02351888
3	Congenital, generalized hypertrichosis (HP:0004540)	3.65002331
4	Pancreatic cysts (HP:0001737)	3.46369505
5	Abnormal biliary tract physiology (HP:0012439)	3.41453111
6	Bile duct proliferation (HP:0001408)	3.41453111
7	Colon cancer (HP:0003003)	3.39887470
8	Tubular atrophy (HP:0000092)	3.24121081
9	Abnormal drinking behavior (HP:0030082)	3.14988464
10	Polydipsia (HP:0001959)	3.14988464
11	Pancreatic fibrosis (HP:0100732)	3.14884818
12	Congenital stationary night blindness (HP:0007642)	3.09531183
13	Abnormality of the renal cortex (HP:0011035)	3.02058021
14	Hyperglycinemia (HP:0002154)	2.97262207
15	Acute necrotizing encephalopathy (HP:0006965)	2.95084796
16	Inability to walk (HP:0002540)	2.90717654
17	Increased corneal curvature (HP:0100692)	2.90571634
18	Keratoconus (HP:0000563)	2.90571634
19	Polyuria (HP:0000103)	2.87485179
20	Nephronophthisis (HP:0000090)	2.84857624
21	Abnormality of the renal medulla (HP:0100957)	2.84841796
22	Increased CSF lactate (HP:0002490)	2.83642514
23	Mitochondrial inheritance (HP:0001427)	2.81971329
24	Abnormal number of erythroid precursors (HP:0012131)	2.80270541
25	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.78926049
26	Optic disc pallor (HP:0000543)	2.66760348
27	Patellar aplasia (HP:0006443)	2.66639130
28	Hypochromic microcytic anemia (HP:0004840)	2.56916815
29	Pendular nystagmus (HP:0012043)	2.55602155
30	Hepatocellular necrosis (HP:0001404)	2.53447568
31	Abolished electroretinogram (ERG) (HP:0000550)	2.52163714
32	Progressive macrocephaly (HP:0004481)	2.50262633
33	Aplasia/Hypoplasia of the patella (HP:0006498)	2.49236044
34	Increased serum lactate (HP:0002151)	2.45908619
35	Abnormality of cells of the erythroid lineage (HP:0012130)	2.45718600
36	Abnormal mitochondria in muscle tissue (HP:0008316)	2.39452421
37	True hermaphroditism (HP:0010459)	2.38048727
38	3-Methylglutaconic aciduria (HP:0003535)	2.35199319
39	Acute encephalopathy (HP:0006846)	2.32995418
40	Tubulointerstitial fibrosis (HP:0005576)	2.32592994
41	Hyperglycinuria (HP:0003108)	2.32077880
42	Sclerocornea (HP:0000647)	2.29587950
43	Progressive inability to walk (HP:0002505)	2.29393075
44	Abnormal urine output (HP:0012590)	2.27880550
45	Lipid accumulation in hepatocytes (HP:0006561)	2.27254822
46	Aplastic anemia (HP:0001915)	2.26495774
47	Hepatic necrosis (HP:0002605)	2.26047186
48	Hypoplasia of the pons (HP:0012110)	2.20906672
49	Poor head control (HP:0002421)	2.20896480
50	Optic nerve coloboma (HP:0000588)	2.19772984
51	Optic nerve hypoplasia (HP:0000609)	2.17992821
52	Increased hepatocellular lipid droplets (HP:0006565)	2.16117453
53	Attenuation of retinal blood vessels (HP:0007843)	2.15485418
54	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.15134813
55	Exotropia (HP:0000577)	2.14329397
56	Fair hair (HP:0002286)	2.13956384
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.11538890
58	Lissencephaly (HP:0001339)	2.10835507
59	Abnormality of the pons (HP:0007361)	2.10534786
60	Impulsivity (HP:0100710)	2.10284665
61	Cystic liver disease (HP:0006706)	2.09728942
62	Constricted visual fields (HP:0001133)	2.09235798
63	Molar tooth sign on MRI (HP:0002419)	2.07520522
64	Abnormality of midbrain morphology (HP:0002418)	2.07520522
65	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.04893570
66	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.04636022
67	Progressive cerebellar ataxia (HP:0002073)	2.03256379
68	IgG deficiency (HP:0004315)	1.96873750
69	Hypophosphatemic rickets (HP:0004912)	1.95378084
70	Tubulointerstitial abnormality (HP:0001969)	1.94826212
71	Congenital hepatic fibrosis (HP:0002612)	1.94267541
72	Abnormality of urine glucose concentration (HP:0011016)	1.92433182
73	Glycosuria (HP:0003076)	1.92433182
74	Volvulus (HP:0002580)	1.92142259
75	Hypomagnesemia (HP:0002917)	1.90763521
76	Abnormality of renal excretion (HP:0011036)	1.88903213
77	Chorioretinal atrophy (HP:0000533)	1.87481399
78	Renal Fanconi syndrome (HP:0001994)	1.87302569
79	Genetic anticipation (HP:0003743)	1.86477128
80	Asplenia (HP:0001746)	1.82691148
81	Chronic hepatic failure (HP:0100626)	1.80825231
82	Birth length less than 3rd percentile (HP:0003561)	1.80409377
83	Supernumerary spleens (HP:0009799)	1.79988653
84	Hypoalbuminemia (HP:0003073)	1.79449946
85	Abnormal albumin level (HP:0012116)	1.79449946
86	Respiratory failure (HP:0002878)	1.79133282
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.79129097
88	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.78279452
89	Pachygyria (HP:0001302)	1.77993565
90	Septo-optic dysplasia (HP:0100842)	1.77111818
91	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76934199
92	Abnormality of glycine metabolism (HP:0010895)	1.76934199
93	Limb dystonia (HP:0002451)	1.74943423
94	Concave nail (HP:0001598)	1.73836788
95	Posterior subcapsular cataract (HP:0007787)	1.72648244
96	Abnormality of the anterior horn cell (HP:0006802)	1.72454621
97	Degeneration of anterior horn cells (HP:0002398)	1.72454621
98	Potter facies (HP:0002009)	1.72245285
99	Facial shape deformation (HP:0011334)	1.72245285
100	Progressive microcephaly (HP:0000253)	1.71415307

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	5.29571938
2	TRIM28	4.30999632
3	TAF1	4.12592218
4	MST4	3.83275672
5	FRK	3.46580858
6	NUAK1	3.29863027
7	TSSK6	2.90617989
8	ADRBK2	2.57682322
9	TIE1	2.55434826
10	MARK1	2.51436394
11	WNK3	2.46036302
12	STK16	2.21456965
13	VRK2	2.12046763
14	ZAK	2.05967862
15	MAP3K4	1.98466235
16	MAP2K7	1.91639068
17	GRK1	1.88052825
18	BMPR1B	1.82880281
19	VRK1	1.65463604
20	ACVR1B	1.64455467
21	WNK4	1.56854042
22	PAK3	1.56256667
23	STK39	1.48946692
24	OXSR1	1.45953886
25	PLK3	1.43360810
26	TAOK3	1.36999060
27	MAP4K2	1.27173895
28	TGFBR1	1.23708962
29	TEC	1.21243855
30	DAPK2	1.17268379
31	NME1	1.06368624
32	TYRO3	1.04287957
33	EPHA3	1.03143103
34	DYRK3	0.96133242
35	TXK	0.95019022
36	ADRBK1	0.93610411
37	PINK1	0.90358276
38	MAP3K9	0.85425530
39	DMPK	0.84524802
40	PASK	0.84393708
41	CDC7	0.84382800
42	BUB1	0.84341822
43	DYRK2	0.80222206
44	ERBB3	0.76032169
45	CAMKK2	0.69612555
46	MAP2K6	0.68042158
47	BCKDK	0.67950674
48	CDK19	0.67660423
49	PDK2	0.66665899
50	PNCK	0.66494569
51	PBK	0.65759724
52	BLK	0.64081737
53	NLK	0.63195544
54	TNIK	0.59325027
55	PIK3CG	0.56136910
56	FGFR2	0.53991879
57	PRKG1	0.52787459
58	MAP2K4	0.52664232
59	TLK1	0.52131106
60	WNK1	0.50928331
61	INSRR	0.50670104
62	PRKCG	0.47471046
63	TTK	0.46375371
64	PLK1	0.46119633
65	BCR	0.44796829
66	IKBKB	0.43692507
67	SRPK1	0.43269759
68	ITK	0.43167764
69	CCNB1	0.41325879
70	PHKG1	0.40617544
71	PHKG2	0.40617544
72	DYRK1B	0.39389698
73	CHEK2	0.39290098
74	STK38L	0.36115429
75	CDK3	0.34549025
76	MAPK13	0.34533520
77	ATR	0.34346198
78	FGR	0.32183148
79	RPS6KA5	0.31842591
80	CSNK1E	0.30720233
81	CSNK2A1	0.27809204
82	PRKAA1	0.27724246
83	MINK1	0.27136998
84	PRKACA	0.26379668
85	ATM	0.25766704
86	PIK3CA	0.25706136
87	ALK	0.24956417
88	CSNK2A2	0.24267890
89	MAPK15	0.23674762
90	WEE1	0.23259710
91	CSNK1G1	0.22866971
92	LYN	0.22798394
93	BTK	0.22603526
94	CDK5	0.21615147
95	STK3	0.21425737
96	MKNK2	0.21350562
97	CAMK2A	0.20084766
98	MAPK9	0.19897315
99	PRKCE	0.19626486
100	PLK4	0.19460581

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.99100464
2	Ribosome_Homo sapiens_hsa03010	3.40846659
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.07134358
4	Basal transcription factors_Homo sapiens_hsa03022	2.94987910
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.88714022
6	Protein export_Homo sapiens_hsa03060	2.85190218
7	RNA polymerase_Homo sapiens_hsa03020	2.70391230
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.39901395
9	One carbon pool by folate_Homo sapiens_hsa00670	2.35485032
10	Parkinsons disease_Homo sapiens_hsa05012	2.23033469
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18036824
12	RNA degradation_Homo sapiens_hsa03018	1.98292868
13	Phototransduction_Homo sapiens_hsa04744	1.93132465
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.92559224
15	Homologous recombination_Homo sapiens_hsa03440	1.88630095
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80569900
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.79389367
18	Caffeine metabolism_Homo sapiens_hsa00232	1.73946038
19	Huntingtons disease_Homo sapiens_hsa05016	1.72942416
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.59946665
21	Propanoate metabolism_Homo sapiens_hsa00640	1.59041237
22	Tryptophan metabolism_Homo sapiens_hsa00380	1.54606186
23	Nicotine addiction_Homo sapiens_hsa05033	1.50263852
24	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44180261
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.38927852
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.32009724
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.30877577
28	Alzheimers disease_Homo sapiens_hsa05010	1.29169529
29	Asthma_Homo sapiens_hsa05310	1.27278434
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.27018438
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.26386781
32	Spliceosome_Homo sapiens_hsa03040	1.22821654
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.20998964
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.20742963
35	Olfactory transduction_Homo sapiens_hsa04740	1.13974398
36	Sulfur relay system_Homo sapiens_hsa04122	1.12184475
37	Allograft rejection_Homo sapiens_hsa05330	1.11898881
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10112212
39	RNA transport_Homo sapiens_hsa03013	1.08982347
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.06256097
41	Butanoate metabolism_Homo sapiens_hsa00650	1.05493425
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.99644056
43	Taste transduction_Homo sapiens_hsa04742	0.99082351
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.98317776
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.98211493
46	DNA replication_Homo sapiens_hsa03030	0.97191137
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95633448
48	Purine metabolism_Homo sapiens_hsa00230	0.94460462
49	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93120628
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91646618
51	Insulin secretion_Homo sapiens_hsa04911	0.91034749
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90435985
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.88212079
54	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.85450997
55	Type I diabetes mellitus_Homo sapiens_hsa04940	0.84789952
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.84620463
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83845667
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.79552230
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79314733
60	Non-homologous end-joining_Homo sapiens_hsa03450	0.74939463
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73544656
62	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70298636
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.70126301
64	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69680032
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.68869533
66	Retinol metabolism_Homo sapiens_hsa00830	0.68271259
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.68080604
68	Mismatch repair_Homo sapiens_hsa03430	0.67904746
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.66416282
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.64604001
71	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.64477349
72	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58722606
73	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.58281665
74	Metabolic pathways_Homo sapiens_hsa01100	0.57755545
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56563762
76	Sulfur metabolism_Homo sapiens_hsa00920	0.56062875
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55145914
78	Chemical carcinogenesis_Homo sapiens_hsa05204	0.53502482
79	Morphine addiction_Homo sapiens_hsa05032	0.53027225
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.50893937
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50510546
82	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.49117106
83	Nitrogen metabolism_Homo sapiens_hsa00910	0.47027114
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.46700552
85	Glutathione metabolism_Homo sapiens_hsa00480	0.46259411
86	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.45451031
87	Fatty acid degradation_Homo sapiens_hsa00071	0.44154956
88	Calcium signaling pathway_Homo sapiens_hsa04020	0.40190653
89	Base excision repair_Homo sapiens_hsa03410	0.39900203
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39442839
91	Histidine metabolism_Homo sapiens_hsa00340	0.39072098
92	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.37692248
93	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.37408698
94	Glutamatergic synapse_Homo sapiens_hsa04724	0.35774601
95	Serotonergic synapse_Homo sapiens_hsa04726	0.34343622
96	Salivary secretion_Homo sapiens_hsa04970	0.32299844
97	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31968744
98	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.26555969
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.26516364
100	ABC transporters_Homo sapiens_hsa02010	0.22765285

PABPC1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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