ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	centriole replication (GO:0007099)	4.47376715
2	protein complex biogenesis (GO:0070271)	4.29213702
3	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.28634852
4	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.28634852
5	NADH dehydrogenase complex assembly (GO:0010257)	4.28634852
6	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.21078069
7	negative regulation of telomere maintenance (GO:0032205)	4.18168280
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.16976995
9	mitochondrial respiratory chain complex assembly (GO:0033108)	3.89867311
10	protein-cofactor linkage (GO:0018065)	3.87950519
11	ATP synthesis coupled proton transport (GO:0015986)	3.85356119
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.85356119
13	DNA damage response, detection of DNA damage (GO:0042769)	3.83226816
14	termination of RNA polymerase III transcription (GO:0006386)	3.81123799
15	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.81123799
16	protein neddylation (GO:0045116)	3.80129947
17	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.76920224
18	behavioral response to ethanol (GO:0048149)	3.73714816
19	respiratory chain complex IV assembly (GO:0008535)	3.70538451
20	platelet dense granule organization (GO:0060155)	3.68976588
21	epithelial cilium movement (GO:0003351)	3.58736955
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.57898004
23	protein polyglutamylation (GO:0018095)	3.51277962
24	DNA deamination (GO:0045006)	3.49254454
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.45275996
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.43456787
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.43456787
28	cytochrome complex assembly (GO:0017004)	3.25443830
29	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.21161615
30	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.21161615
31	regulation of translation, ncRNA-mediated (GO:0045974)	3.21161615
32	preassembly of GPI anchor in ER membrane (GO:0016254)	3.15456989
33	response to pheromone (GO:0019236)	3.12748874
34	chaperone-mediated protein transport (GO:0072321)	3.12599193
35	regulation of telomere maintenance (GO:0032204)	3.10791343
36	behavioral response to nicotine (GO:0035095)	3.08100338
37	regulation of telomere maintenance via telomerase (GO:0032210)	3.05941468
38	GPI anchor metabolic process (GO:0006505)	3.04799496
39	regulation of cilium movement (GO:0003352)	3.03727529
40	proteasome assembly (GO:0043248)	2.98602208
41	GTP biosynthetic process (GO:0006183)	2.96490228
42	anterograde synaptic vesicle transport (GO:0048490)	2.95276368
43	intraciliary transport (GO:0042073)	2.93360516
44	tRNA processing (GO:0008033)	2.93265677
45	C-terminal protein lipidation (GO:0006501)	2.91929338
46	centriole assembly (GO:0098534)	2.91310405
47	axoneme assembly (GO:0035082)	2.88753694
48	negative regulation of telomerase activity (GO:0051974)	2.83758080
49	cullin deneddylation (GO:0010388)	2.82409636
50	electron transport chain (GO:0022900)	2.80005329
51	respiratory electron transport chain (GO:0022904)	2.77461197
52	dopamine transport (GO:0015872)	2.74687793
53	positive regulation of prostaglandin secretion (GO:0032308)	2.74160104
54	cilium morphogenesis (GO:0060271)	2.71796274
55	pyrimidine nucleobase catabolic process (GO:0006208)	2.70377263
56	regulation of helicase activity (GO:0051095)	2.69622969
57	L-fucose catabolic process (GO:0042355)	2.69025478
58	fucose catabolic process (GO:0019317)	2.69025478
59	L-fucose metabolic process (GO:0042354)	2.69025478
60	intracellular protein transmembrane import (GO:0044743)	2.66781737
61	detection of light stimulus involved in visual perception (GO:0050908)	2.66726868
62	detection of light stimulus involved in sensory perception (GO:0050962)	2.66726868
63	tRNA modification (GO:0006400)	2.64584539
64	water-soluble vitamin biosynthetic process (GO:0042364)	2.63861147
65	GPI anchor biosynthetic process (GO:0006506)	2.63720682
66	alanine transport (GO:0032328)	2.59786475
67	neural tube formation (GO:0001841)	2.58630780
68	protein deneddylation (GO:0000338)	2.54813451
69	regulation of feeding behavior (GO:0060259)	2.52642477
70	protein K6-linked ubiquitination (GO:0085020)	2.52057106
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.50439143
72	cilium movement (GO:0003341)	2.48751694
73	C-terminal protein amino acid modification (GO:0018410)	2.47991704
74	cell proliferation in forebrain (GO:0021846)	2.47256313
75	protein localization to cilium (GO:0061512)	2.44216855
76	negative regulation of cell cycle arrest (GO:0071157)	2.43953688
77	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.42194450
78	base-excision repair, AP site formation (GO:0006285)	2.41905115
79	nucleobase catabolic process (GO:0046113)	2.41868869
80	7-methylguanosine mRNA capping (GO:0006370)	2.41864079
81	mannosylation (GO:0097502)	2.41149920
82	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.41066688
83	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.40398905
84	substrate-independent telencephalic tangential migration (GO:0021826)	2.40398905
85	seminiferous tubule development (GO:0072520)	2.40048057
86	7-methylguanosine RNA capping (GO:0009452)	2.36751042
87	RNA capping (GO:0036260)	2.36751042
88	negative regulation of mast cell activation (GO:0033004)	2.36386502
89	recombinational repair (GO:0000725)	2.36353889
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.36327948
91	ketone body metabolic process (GO:1902224)	2.35617412
92	double-strand break repair via homologous recombination (GO:0000724)	2.35133023
93	kinetochore assembly (GO:0051382)	2.34644213
94	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.34322220
95	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.34122707
96	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.34122707
97	single strand break repair (GO:0000012)	2.33488143
98	regulation of penile erection (GO:0060405)	2.33245867
99	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.32295499
100	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.32295499

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.91730741
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.69412887
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.47634967
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.38247130
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.11695102
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08704576
7	VDR_22108803_ChIP-Seq_LS180_Human	2.92323760
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.54740108
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.42336539
10	EWS_26573619_Chip-Seq_HEK293_Human	2.35148924
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32532664
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.31465540
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.27798555
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.26784819
15	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.16744360
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.15463874
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11683669
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03879539
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03256627
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.99318218
21	FUS_26573619_Chip-Seq_HEK293_Human	1.94252381
22	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88086042
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.78215875
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.77996482
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77782072
26	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.77270244
27	P300_19829295_ChIP-Seq_ESCs_Human	1.76589389
28	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.76004191
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.72945178
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.71701929
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.65031835
32	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61244971
33	ER_23166858_ChIP-Seq_MCF-7_Human	1.61212519
34	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.56748368
35	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54733012
36	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47522417
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.42992004
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.42731547
39	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41554659
40	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38118711
41	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.36062561
42	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.35869914
43	CBP_20019798_ChIP-Seq_JUKART_Human	1.35869914
44	GBX2_23144817_ChIP-Seq_PC3_Human	1.32666740
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32496514
46	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.32213758
47	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30839722
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30611952
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25126535
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25126535
51	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.23632108
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23475598
53	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23198188
54	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23198188
55	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21974758
56	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.20727598
57	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.20092804
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19969169
59	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19969169
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18015268
61	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17799189
62	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.17649251
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17346098
64	NCOR_22424771_ChIP-Seq_293T_Human	1.17090525
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.16788033
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.13636443
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.13586664
68	SMAD4_21799915_ChIP-Seq_A2780_Human	1.11118747
69	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.09964565
70	BCAT_22108803_ChIP-Seq_LS180_Human	1.08349783
71	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.08039190
72	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06942671
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06413673
74	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06181852
75	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.05810453
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.05395791
77	AR_25329375_ChIP-Seq_VCAP_Human	1.05096629
78	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03765403
79	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03736667
80	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.02908565
81	AR_20517297_ChIP-Seq_VCAP_Human	1.02652879
82	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02367178
83	ETV1_20927104_ChIP-Seq_GIST48_Human	1.01725104
84	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.01390398
85	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01035961
86	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00405608
87	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.00099902
88	TTF2_22483619_ChIP-Seq_HELA_Human	1.00029303
89	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.99784687
90	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99090670
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98862263
92	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97940071
93	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97901107
94	STAT3_23295773_ChIP-Seq_U87_Human	0.97894231
95	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97255142
96	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.97160959
97	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.97016984
98	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.96426285
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95957141
100	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.95940855

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.38868605
2	MP0003787_abnormal_imprinting	3.48880961
3	MP0006292_abnormal_olfactory_placode	3.05723846
4	MP0002163_abnormal_gland_morphology	2.61498358
5	MP0003880_abnormal_central_pattern	2.56987084
6	MP0005646_abnormal_pituitary_gland	2.32197573
7	MP0008877_abnormal_DNA_methylation	2.16730211
8	MP0004133_heterotaxia	2.16089687
9	MP0006276_abnormal_autonomic_nervous	2.07309355
10	MP0008058_abnormal_DNA_repair	2.06412067
11	MP0002938_white_spotting	2.05835460
12	MP0004147_increased_porphyrin_level	2.05339690
13	MP0005551_abnormal_eye_electrophysiolog	2.00724269
14	MP0000013_abnormal_adipose_tissue	1.96580016
15	MP0005075_abnormal_melanosome_morpholog	1.91973167
16	MP0004885_abnormal_endolymph	1.90914353
17	MP0005379_endocrine/exocrine_gland_phen	1.90324558
18	MP0008004_abnormal_stomach_pH	1.84224793
19	MP0005645_abnormal_hypothalamus_physiol	1.67356562
20	MP0000631_abnormal_neuroendocrine_gland	1.63782076
21	MP0000372_irregular_coat_pigmentation	1.62800391
22	MP0002736_abnormal_nociception_after	1.55935836
23	MP0006072_abnormal_retinal_apoptosis	1.53185514
24	MP0001502_abnormal_circadian_rhythm	1.48447948
25	MP0003878_abnormal_ear_physiology	1.45112042
26	MP0005377_hearing/vestibular/ear_phenot	1.45112042
27	MP0008875_abnormal_xenobiotic_pharmacok	1.44054155
28	MP0001485_abnormal_pinna_reflex	1.42503253
29	MP0004142_abnormal_muscle_tone	1.41198087
30	MP0002272_abnormal_nervous_system	1.40219995
31	MP0008789_abnormal_olfactory_epithelium	1.39862542
32	MP0001968_abnormal_touch/_nociception	1.35952457
33	MP0001984_abnormal_olfaction	1.35839593
34	MP0005084_abnormal_gallbladder_morpholo	1.35711295
35	MP0000427_abnormal_hair_cycle	1.35266740
36	MP0001986_abnormal_taste_sensitivity	1.34742526
37	MP0001486_abnormal_startle_reflex	1.33127205
38	MP0008995_early_reproductive_senescence	1.32304843
39	MP0003121_genomic_imprinting	1.31239302
40	MP0008872_abnormal_physiological_respon	1.30213123
41	MP0009745_abnormal_behavioral_response	1.30138662
42	MP0005253_abnormal_eye_physiology	1.27319952
43	MP0001501_abnormal_sleep_pattern	1.25646905
44	MP0002653_abnormal_ependyma_morphology	1.22272603
45	MP0002282_abnormal_trachea_morphology	1.20441673
46	MP0001764_abnormal_homeostasis	1.19581051
47	MP0003646_muscle_fatigue	1.13554108
48	MP0000647_abnormal_sebaceous_gland	1.12936871
49	MP0002751_abnormal_autonomic_nervous	1.12037198
50	MP0002876_abnormal_thyroid_physiology	1.12029705
51	MP0002160_abnormal_reproductive_system	1.07020394
52	MP0000778_abnormal_nervous_system	1.06285776
53	MP0003136_yellow_coat_color	1.05136547
54	MP0006036_abnormal_mitochondrial_physio	1.02454122
55	MP0003786_premature_aging	1.02067433
56	MP0002837_dystrophic_cardiac_calcinosis	1.01581728
57	MP0002572_abnormal_emotion/affect_behav	0.99500248
58	MP0008775_abnormal_heart_ventricle	0.99016246
59	MP0002638_abnormal_pupillary_reflex	0.96316329
60	MP0001919_abnormal_reproductive_system	0.95459792
61	MP0009046_muscle_twitch	0.94940535
62	MP0002095_abnormal_skin_pigmentation	0.94847706
63	MP0002210_abnormal_sex_determination	0.93749803
64	MP0003011_delayed_dark_adaptation	0.93019899
65	MP0003186_abnormal_redox_activity	0.91897517
66	MP0005389_reproductive_system_phenotype	0.90709018
67	MP0002234_abnormal_pharynx_morphology	0.90514168
68	MP0002557_abnormal_social/conspecific_i	0.90195869
69	MP0003195_calcinosis	0.88893483
70	MP0005195_abnormal_posterior_eye	0.88684692
71	MP0000003_abnormal_adipose_tissue	0.87687349
72	MP0001929_abnormal_gametogenesis	0.84717105
73	MP0004145_abnormal_muscle_electrophysio	0.84189251
74	MP0005085_abnormal_gallbladder_physiolo	0.84048502
75	MP0005332_abnormal_amino_acid	0.83322889
76	MP0001963_abnormal_hearing_physiology	0.83177807
77	MP0001119_abnormal_female_reproductive	0.82931434
78	MP0002752_abnormal_somatic_nervous	0.82715049
79	MP0000653_abnormal_sex_gland	0.81313122
80	MP0001529_abnormal_vocalization	0.81015792
81	MP0005499_abnormal_olfactory_system	0.80960341
82	MP0005394_taste/olfaction_phenotype	0.80960341
83	MP0004742_abnormal_vestibular_system	0.80607814
84	MP0002733_abnormal_thermal_nociception	0.78281521
85	MP0003635_abnormal_synaptic_transmissio	0.78203436
86	MP0005410_abnormal_fertilization	0.76849729
87	MP0003755_abnormal_palate_morphology	0.76255198
88	MP0003698_abnormal_male_reproductive	0.75763082
89	MP0000026_abnormal_inner_ear	0.75273042
90	MP0003938_abnormal_ear_development	0.75238185
91	MP0000230_abnormal_systemic_arterial	0.74975579
92	MP0009764_decreased_sensitivity_to	0.73882125
93	MP0002233_abnormal_nose_morphology	0.73260248
94	MP0005386_behavior/neurological_phenoty	0.72704591
95	MP0004924_abnormal_behavior	0.72704591
96	MP0001970_abnormal_pain_threshold	0.72190031
97	MP0002184_abnormal_innervation	0.72119355
98	MP0001145_abnormal_male_reproductive	0.72034110
99	MP0001324_abnormal_eye_pigmentation	0.71843947
100	MP0002064_seizures	0.71490849

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	4.07212134
2	Molar tooth sign on MRI (HP:0002419)	4.07212134
3	Pancreatic cysts (HP:0001737)	3.94518841
4	Pancreatic fibrosis (HP:0100732)	3.81235846
5	Acute necrotizing encephalopathy (HP:0006965)	3.57188605
6	Increased CSF lactate (HP:0002490)	3.37205416
7	Mitochondrial inheritance (HP:0001427)	3.37158970
8	Nephronophthisis (HP:0000090)	3.35761536
9	True hermaphroditism (HP:0010459)	3.21078035
10	Hepatocellular necrosis (HP:0001404)	3.14422554
11	Progressive macrocephaly (HP:0004481)	3.12194474
12	Renal Fanconi syndrome (HP:0001994)	3.10248119
13	Abnormal mitochondria in muscle tissue (HP:0008316)	3.06110892
14	Acute encephalopathy (HP:0006846)	2.99347641
15	Abnormality of the renal medulla (HP:0100957)	2.95590116
16	Abnormal biliary tract physiology (HP:0012439)	2.91901790
17	Bile duct proliferation (HP:0001408)	2.91901790
18	Hepatic necrosis (HP:0002605)	2.85118028
19	Hypokalemic alkalosis (HP:0001949)	2.74050721
20	Increased hepatocellular lipid droplets (HP:0006565)	2.70270140
21	Abnormality of the renal cortex (HP:0011035)	2.68045639
22	Optic disc pallor (HP:0000543)	2.66891361
23	Metabolic alkalosis (HP:0200114)	2.65553362
24	Chronic hepatic failure (HP:0100626)	2.62971461
25	Abnormality of renal resorption (HP:0011038)	2.60944997
26	Type II lissencephaly (HP:0007260)	2.59955307
27	3-Methylglutaconic aciduria (HP:0003535)	2.58383226
28	Anterior segment dysgenesis (HP:0007700)	2.56838020
29	Polyuria (HP:0000103)	2.55688669
30	Cystic liver disease (HP:0006706)	2.52795623
31	Progressive microcephaly (HP:0000253)	2.51828622
32	Renal cortical cysts (HP:0000803)	2.50016208
33	Lipid accumulation in hepatocytes (HP:0006561)	2.44982836
34	Increased serum pyruvate (HP:0003542)	2.43010618
35	Increased serum lactate (HP:0002151)	2.40605407
36	Methylmalonic acidemia (HP:0002912)	2.35121528
37	Hypoplasia of the fovea (HP:0007750)	2.33417495
38	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.33417495
39	Congenital stationary night blindness (HP:0007642)	2.29472838
40	Neoplasm of the adrenal cortex (HP:0100641)	2.28985272
41	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.26733377
42	Abnormality of alanine metabolism (HP:0010916)	2.26733377
43	Hyperalaninemia (HP:0003348)	2.26733377
44	Cerebral edema (HP:0002181)	2.26590261
45	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.24092089
46	Absent speech (HP:0001344)	2.20551862
47	Abnormality of the fovea (HP:0000493)	2.19316186
48	Abolished electroretinogram (ERG) (HP:0000550)	2.13788153
49	Tubulointerstitial nephritis (HP:0001970)	2.13472786
50	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.12840487
51	Abnormality of methionine metabolism (HP:0010901)	2.12107100
52	Optic nerve hypoplasia (HP:0000609)	2.10570280
53	Medial flaring of the eyebrow (HP:0010747)	2.08816871
54	Lactic acidosis (HP:0003128)	2.05533144
55	Elevated erythrocyte sedimentation rate (HP:0003565)	2.05235607
56	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.04418694
57	Anencephaly (HP:0002323)	2.01005267
58	Abnormal urine output (HP:0012590)	2.00307190
59	Abnormal number of erythroid precursors (HP:0012131)	1.98150834
60	Sclerocornea (HP:0000647)	1.97880160
61	Abnormality of macular pigmentation (HP:0008002)	1.97223014
62	Inability to walk (HP:0002540)	1.97206365
63	Abnormality of B cell number (HP:0010975)	1.94404015
64	Retinal dysplasia (HP:0007973)	1.92976779
65	Cerebellar dysplasia (HP:0007033)	1.92925089
66	Congenital hepatic fibrosis (HP:0002612)	1.91912715
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.91368118
68	Absent/shortened dynein arms (HP:0200106)	1.91368118
69	B lymphocytopenia (HP:0010976)	1.90425916
70	Posterior subcapsular cataract (HP:0007787)	1.90118507
71	Patent foramen ovale (HP:0001655)	1.89752333
72	Attenuation of retinal blood vessels (HP:0007843)	1.87419631
73	Polydipsia (HP:0001959)	1.86340667
74	Abnormal drinking behavior (HP:0030082)	1.86340667
75	Postaxial foot polydactyly (HP:0001830)	1.85955111
76	Abnormality of cells of the erythroid lineage (HP:0012130)	1.85192635
77	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.84978687
78	Chorioretinal coloboma (HP:0000567)	1.83814524
79	Oligodactyly (hands) (HP:0001180)	1.83592832
80	Hyperaldosteronism (HP:0000859)	1.82776519
81	Pendular nystagmus (HP:0012043)	1.81797065
82	Abnormal rod and cone electroretinograms (HP:0008323)	1.80205644
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.80127310
84	Thyroiditis (HP:0100646)	1.79683241
85	Narrow forehead (HP:0000341)	1.79019586
86	Asplenia (HP:0001746)	1.78494925
87	Leukodystrophy (HP:0002415)	1.78391560
88	Intestinal atresia (HP:0011100)	1.77127922
89	Increased corneal curvature (HP:0100692)	1.76882672
90	Keratoconus (HP:0000563)	1.76882672
91	Tubulointerstitial abnormality (HP:0001969)	1.74606629
92	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.73201638
93	Hyperventilation (HP:0002883)	1.71991274
94	Renal salt wasting (HP:0000127)	1.70727431
95	Sloping forehead (HP:0000340)	1.70400901
96	Microvesicular hepatic steatosis (HP:0001414)	1.69954424
97	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.69017784
98	Congenital, generalized hypertrichosis (HP:0004540)	1.68876332
99	Rib fusion (HP:0000902)	1.68337620
100	Decreased central vision (HP:0007663)	1.67027533

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.43683364
2	CASK	4.03199382
3	BMPR1B	3.95969542
4	ZAK	3.25036844
5	NEK1	2.98717739
6	MAP4K2	2.93013454
7	FRK	2.78007402
8	WNK3	2.56974003
9	NUAK1	2.43608851
10	STK16	2.10695694
11	TAOK2	1.98768503
12	BCKDK	1.91728225
13	MUSK	1.85553804
14	TAOK3	1.80227522
15	TNIK	1.79617370
16	MAP2K6	1.77441541
17	TSSK6	1.75433438
18	MAPK13	1.74207427
19	WNK4	1.55472900
20	TRIM28	1.46772005
21	STK39	1.40646112
22	ADRBK2	1.39326071
23	PINK1	1.36070675
24	ERBB3	1.34845645
25	GRK1	1.34788264
26	MST4	1.32098804
27	VRK1	1.31840202
28	MAP3K4	1.24747524
29	MAP3K5	1.24602038
30	CCNB1	1.22223170
31	BCR	1.15844948
32	MINK1	1.09637911
33	OXSR1	1.06637454
34	DYRK2	1.02770247
35	PAK3	0.95003010
36	BMPR2	0.90540841
37	MAP3K12	0.89378045
38	WEE1	0.88299197
39	TXK	0.85510586
40	PLK3	0.84946221
41	PIK3CA	0.83578478
42	CDK19	0.81882493
43	PRKCG	0.79935204
44	TEC	0.78629673
45	PRKCQ	0.77764998
46	NLK	0.72606936
47	MKNK2	0.71157089
48	PIM1	0.70770698
49	VRK2	0.67605222
50	CSNK1G2	0.67365452
51	SIK3	0.67083031
52	TNK2	0.67068576
53	PKN1	0.66966809
54	IKBKB	0.65586054
55	CSNK1G3	0.64873631
56	FGFR2	0.63383645
57	NTRK2	0.63148884
58	PHKG1	0.61728325
59	PHKG2	0.61728325
60	MKNK1	0.60936558
61	EIF2AK3	0.59728259
62	CSNK1G1	0.58157655
63	MAP2K7	0.57667802
64	SRPK1	0.57591112
65	CSNK1A1L	0.57048206
66	FLT3	0.55112592
67	DAPK3	0.54165365
68	ITK	0.54068228
69	INSRR	0.54061941
70	ADRBK1	0.53934172
71	PLK4	0.51065872
72	PLK2	0.49442847
73	PNCK	0.47459030
74	ATR	0.47180434
75	CDK8	0.45838314
76	MARK1	0.45696997
77	RPS6KA5	0.44764207
78	PLK1	0.38538389
79	TGFBR1	0.37859777
80	PRKCE	0.37240842
81	STK38L	0.37027077
82	DAPK2	0.35919273
83	MAPKAPK3	0.34071465
84	NEK2	0.33695752
85	GRK6	0.33610116
86	CHEK2	0.31895846
87	NME1	0.31705868
88	CSNK2A1	0.31458643
89	ATM	0.31227957
90	CSNK2A2	0.30570782
91	NTRK3	0.28785443
92	PRKACA	0.28494711
93	CSNK1D	0.27242969
94	TRPM7	0.27043366
95	AKT3	0.26861627
96	AURKB	0.25940951
97	RPS6KB1	0.25674861
98	TIE1	0.25017241
99	PRKCD	0.24999758
100	PRKCA	0.23793832

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.66812886
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.51257422
3	RNA polymerase_Homo sapiens_hsa03020	3.06143023
4	Protein export_Homo sapiens_hsa03060	2.95490755
5	Parkinsons disease_Homo sapiens_hsa05012	2.91215847
6	Proteasome_Homo sapiens_hsa03050	2.64193936
7	Ribosome_Homo sapiens_hsa03010	2.55833749
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.45437474
9	Phototransduction_Homo sapiens_hsa04744	2.38875481
10	Basal transcription factors_Homo sapiens_hsa03022	2.31430172
11	Homologous recombination_Homo sapiens_hsa03440	2.22756717
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.15131272
13	Butanoate metabolism_Homo sapiens_hsa00650	2.09064655
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.08774203
15	Huntingtons disease_Homo sapiens_hsa05016	2.04207360
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.86552768
17	RNA degradation_Homo sapiens_hsa03018	1.84949210
18	Alzheimers disease_Homo sapiens_hsa05010	1.77267630
19	Base excision repair_Homo sapiens_hsa03410	1.72110613
20	Collecting duct acid secretion_Homo sapiens_hsa04966	1.71190499
21	Propanoate metabolism_Homo sapiens_hsa00640	1.69913835
22	Asthma_Homo sapiens_hsa05310	1.65323986
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.62373155
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.61336459
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.54675682
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.52857928
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52161398
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.31146171
29	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.30987338
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27184214
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.25237415
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.24985545
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22766762
34	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19356351
35	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.16311074
36	Non-homologous end-joining_Homo sapiens_hsa03450	1.14237347
37	Olfactory transduction_Homo sapiens_hsa04740	1.11170310
38	RNA transport_Homo sapiens_hsa03013	1.10166327
39	Purine metabolism_Homo sapiens_hsa00230	1.07450031
40	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.04794810
41	Peroxisome_Homo sapiens_hsa04146	1.03548118
42	One carbon pool by folate_Homo sapiens_hsa00670	1.00767251
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.98593252
44	Nicotine addiction_Homo sapiens_hsa05033	0.98582284
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.96335689
46	Regulation of autophagy_Homo sapiens_hsa04140	0.95914165
47	Spliceosome_Homo sapiens_hsa03040	0.93925674
48	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85416513
49	Tryptophan metabolism_Homo sapiens_hsa00380	0.83710240
50	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.81344594
51	Caffeine metabolism_Homo sapiens_hsa00232	0.78368559
52	Allograft rejection_Homo sapiens_hsa05330	0.77888363
53	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.75580104
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.70247830
55	Sulfur metabolism_Homo sapiens_hsa00920	0.68754804
56	p53 signaling pathway_Homo sapiens_hsa04115	0.68661974
57	Metabolic pathways_Homo sapiens_hsa01100	0.68362265
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.68222633
59	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.66159106
60	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.65744246
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64216400
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.64071385
63	Glutathione metabolism_Homo sapiens_hsa00480	0.64021464
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63735352
65	Taste transduction_Homo sapiens_hsa04742	0.62959888
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.62326095
67	Graft-versus-host disease_Homo sapiens_hsa05332	0.61396145
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.59603028
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.58218083
70	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58181487
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.58091683
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57211934
73	Morphine addiction_Homo sapiens_hsa05032	0.54874578
74	Retinol metabolism_Homo sapiens_hsa00830	0.52949743
75	Fatty acid elongation_Homo sapiens_hsa00062	0.52855684
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49866333
77	Mismatch repair_Homo sapiens_hsa03430	0.49809518
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.49236626
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.48110358
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.47764208
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47091589
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.47033361
83	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.46914512
84	Circadian rhythm_Homo sapiens_hsa04710	0.46710640
85	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45035052
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44642458
87	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44384841
88	Ether lipid metabolism_Homo sapiens_hsa00565	0.43474995
89	Circadian entrainment_Homo sapiens_hsa04713	0.41252553
90	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.39528671
91	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.38509760
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37703398
93	Insulin secretion_Homo sapiens_hsa04911	0.37537235
94	Fatty acid degradation_Homo sapiens_hsa00071	0.36346362
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.35731851
96	Serotonergic synapse_Homo sapiens_hsa04726	0.34235247
97	Cocaine addiction_Homo sapiens_hsa05030	0.31439507
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29439803
99	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.27556386
100	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.25230313

PABPC1P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »