PABPC1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)4.47376715
2protein complex biogenesis (GO:0070271)4.29213702
3mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.28634852
4mitochondrial respiratory chain complex I assembly (GO:0032981)4.28634852
5NADH dehydrogenase complex assembly (GO:0010257)4.28634852
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.21078069
7negative regulation of telomere maintenance (GO:0032205)4.18168280
8establishment of protein localization to mitochondrial membrane (GO:0090151)4.16976995
9mitochondrial respiratory chain complex assembly (GO:0033108)3.89867311
10protein-cofactor linkage (GO:0018065)3.87950519
11energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85356119
12ATP synthesis coupled proton transport (GO:0015986)3.85356119
13DNA damage response, detection of DNA damage (GO:0042769)3.83226816
14transcription elongation from RNA polymerase III promoter (GO:0006385)3.81123799
15termination of RNA polymerase III transcription (GO:0006386)3.81123799
16protein neddylation (GO:0045116)3.80129947
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.76920224
18behavioral response to ethanol (GO:0048149)3.73714816
19respiratory chain complex IV assembly (GO:0008535)3.70538451
20platelet dense granule organization (GO:0060155)3.68976588
21epithelial cilium movement (GO:0003351)3.58736955
22detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.57898004
23protein polyglutamylation (GO:0018095)3.51277962
24DNA deamination (GO:0045006)3.49254454
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45275996
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43456787
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43456787
28cytochrome complex assembly (GO:0017004)3.25443830
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.21161615
30regulation of translation, ncRNA-mediated (GO:0045974)3.21161615
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.21161615
32preassembly of GPI anchor in ER membrane (GO:0016254)3.15456989
33response to pheromone (GO:0019236)3.12748874
34chaperone-mediated protein transport (GO:0072321)3.12599193
35regulation of telomere maintenance (GO:0032204)3.10791343
36behavioral response to nicotine (GO:0035095)3.08100338
37regulation of telomere maintenance via telomerase (GO:0032210)3.05941468
38GPI anchor metabolic process (GO:0006505)3.04799496
39regulation of cilium movement (GO:0003352)3.03727529
40proteasome assembly (GO:0043248)2.98602208
41GTP biosynthetic process (GO:0006183)2.96490228
42anterograde synaptic vesicle transport (GO:0048490)2.95276368
43intraciliary transport (GO:0042073)2.93360516
44tRNA processing (GO:0008033)2.93265677
45C-terminal protein lipidation (GO:0006501)2.91929338
46centriole assembly (GO:0098534)2.91310405
47axoneme assembly (GO:0035082)2.88753694
48negative regulation of telomerase activity (GO:0051974)2.83758080
49cullin deneddylation (GO:0010388)2.82409636
50electron transport chain (GO:0022900)2.80005329
51respiratory electron transport chain (GO:0022904)2.77461197
52dopamine transport (GO:0015872)2.74687793
53positive regulation of prostaglandin secretion (GO:0032308)2.74160104
54cilium morphogenesis (GO:0060271)2.71796274
55pyrimidine nucleobase catabolic process (GO:0006208)2.70377263
56regulation of helicase activity (GO:0051095)2.69622969
57fucose catabolic process (GO:0019317)2.69025478
58L-fucose metabolic process (GO:0042354)2.69025478
59L-fucose catabolic process (GO:0042355)2.69025478
60intracellular protein transmembrane import (GO:0044743)2.66781737
61detection of light stimulus involved in sensory perception (GO:0050962)2.66726868
62detection of light stimulus involved in visual perception (GO:0050908)2.66726868
63tRNA modification (GO:0006400)2.64584539
64water-soluble vitamin biosynthetic process (GO:0042364)2.63861147
65GPI anchor biosynthetic process (GO:0006506)2.63720682
66alanine transport (GO:0032328)2.59786475
67neural tube formation (GO:0001841)2.58630780
68protein deneddylation (GO:0000338)2.54813451
69regulation of feeding behavior (GO:0060259)2.52642477
70protein K6-linked ubiquitination (GO:0085020)2.52057106
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50439143
72cilium movement (GO:0003341)2.48751694
73C-terminal protein amino acid modification (GO:0018410)2.47991704
74cell proliferation in forebrain (GO:0021846)2.47256313
75protein localization to cilium (GO:0061512)2.44216855
76negative regulation of cell cycle arrest (GO:0071157)2.43953688
77purine nucleoside triphosphate biosynthetic process (GO:0009145)2.42194450
78base-excision repair, AP site formation (GO:0006285)2.41905115
79nucleobase catabolic process (GO:0046113)2.41868869
807-methylguanosine mRNA capping (GO:0006370)2.41864079
81mannosylation (GO:0097502)2.41149920
82purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.41066688
83substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.40398905
84substrate-independent telencephalic tangential migration (GO:0021826)2.40398905
85seminiferous tubule development (GO:0072520)2.40048057
86RNA capping (GO:0036260)2.36751042
877-methylguanosine RNA capping (GO:0009452)2.36751042
88negative regulation of mast cell activation (GO:0033004)2.36386502
89recombinational repair (GO:0000725)2.36353889
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.36327948
91ketone body metabolic process (GO:1902224)2.35617412
92double-strand break repair via homologous recombination (GO:0000724)2.35133023
93kinetochore assembly (GO:0051382)2.34644213
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.34322220
95positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.34122707
96regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.34122707
97single strand break repair (GO:0000012)2.33488143
98regulation of penile erection (GO:0060405)2.33245867
99positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.32295499
100regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.32295499

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.91730741
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.69412887
3ZNF274_21170338_ChIP-Seq_K562_Hela3.47634967
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.38247130
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.11695102
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.08704576
7VDR_22108803_ChIP-Seq_LS180_Human2.92323760
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.54740108
9TAF15_26573619_Chip-Seq_HEK293_Human2.42336539
10EWS_26573619_Chip-Seq_HEK293_Human2.35148924
11MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32532664
12EZH2_22144423_ChIP-Seq_EOC_Human2.31465540
13VDR_23849224_ChIP-Seq_CD4+_Human2.27798555
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26784819
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16744360
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15463874
17ELK1_19687146_ChIP-ChIP_HELA_Human2.11683669
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.03879539
19IGF1R_20145208_ChIP-Seq_DFB_Human2.03256627
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.99318218
21FUS_26573619_Chip-Seq_HEK293_Human1.94252381
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88086042
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.78215875
24MYC_18940864_ChIP-ChIP_HL60_Human1.77996482
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77782072
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.77270244
27P300_19829295_ChIP-Seq_ESCs_Human1.76589389
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76004191
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.72945178
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71701929
31TP53_22573176_ChIP-Seq_HFKS_Human1.65031835
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61244971
33ER_23166858_ChIP-Seq_MCF-7_Human1.61212519
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56748368
35FOXP3_21729870_ChIP-Seq_TREG_Human1.54733012
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.47522417
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42992004
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.42731547
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.41554659
40IRF1_19129219_ChIP-ChIP_H3396_Human1.38118711
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36062561
42CBP_20019798_ChIP-Seq_JUKART_Human1.35869914
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35869914
44GBX2_23144817_ChIP-Seq_PC3_Human1.32666740
45PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32496514
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.32213758
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30839722
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30611952
49SOX2_19829295_ChIP-Seq_ESCs_Human1.25126535
50NANOG_19829295_ChIP-Seq_ESCs_Human1.25126535
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.23632108
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23475598
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23198188
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.23198188
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.21974758
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.20727598
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20092804
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19969169
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19969169
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18015268
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.17799189
62E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17649251
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17346098
64NCOR_22424771_ChIP-Seq_293T_Human1.17090525
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.16788033
66RNF2_27304074_Chip-Seq_NSC_Mouse1.13636443
67TCF4_22108803_ChIP-Seq_LS180_Human1.13586664
68SMAD4_21799915_ChIP-Seq_A2780_Human1.11118747
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09964565
70BCAT_22108803_ChIP-Seq_LS180_Human1.08349783
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08039190
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06942671
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06413673
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06181852
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05810453
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05395791
77AR_25329375_ChIP-Seq_VCAP_Human1.05096629
78P53_22387025_ChIP-Seq_ESCs_Mouse1.03765403
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03736667
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.02908565
81AR_20517297_ChIP-Seq_VCAP_Human1.02652879
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02367178
83ETV1_20927104_ChIP-Seq_GIST48_Human1.01725104
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01390398
85RBPJ_21746931_ChIP-Seq_IB4_Human1.01035961
86DCP1A_22483619_ChIP-Seq_HELA_Human1.00405608
87FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00099902
88TTF2_22483619_ChIP-Seq_HELA_Human1.00029303
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.99784687
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99090670
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98862263
92RUNX2_22187159_ChIP-Seq_PCA_Human0.97940071
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97901107
94STAT3_23295773_ChIP-Seq_U87_Human0.97894231
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97255142
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.97160959
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.97016984
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96426285
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.95957141
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95940855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.38868605
2MP0003787_abnormal_imprinting3.48880961
3MP0006292_abnormal_olfactory_placode3.05723846
4MP0002163_abnormal_gland_morphology2.61498358
5MP0003880_abnormal_central_pattern2.56987084
6MP0005646_abnormal_pituitary_gland2.32197573
7MP0008877_abnormal_DNA_methylation2.16730211
8MP0004133_heterotaxia2.16089687
9MP0006276_abnormal_autonomic_nervous2.07309355
10MP0008058_abnormal_DNA_repair2.06412067
11MP0002938_white_spotting2.05835460
12MP0004147_increased_porphyrin_level2.05339690
13MP0005551_abnormal_eye_electrophysiolog2.00724269
14MP0000013_abnormal_adipose_tissue1.96580016
15MP0005075_abnormal_melanosome_morpholog1.91973167
16MP0004885_abnormal_endolymph1.90914353
17MP0005379_endocrine/exocrine_gland_phen1.90324558
18MP0008004_abnormal_stomach_pH1.84224793
19MP0005645_abnormal_hypothalamus_physiol1.67356562
20MP0000631_abnormal_neuroendocrine_gland1.63782076
21MP0000372_irregular_coat_pigmentation1.62800391
22MP0002736_abnormal_nociception_after1.55935836
23MP0006072_abnormal_retinal_apoptosis1.53185514
24MP0001502_abnormal_circadian_rhythm1.48447948
25MP0005377_hearing/vestibular/ear_phenot1.45112042
26MP0003878_abnormal_ear_physiology1.45112042
27MP0008875_abnormal_xenobiotic_pharmacok1.44054155
28MP0001485_abnormal_pinna_reflex1.42503253
29MP0004142_abnormal_muscle_tone1.41198087
30MP0002272_abnormal_nervous_system1.40219995
31MP0008789_abnormal_olfactory_epithelium1.39862542
32MP0001968_abnormal_touch/_nociception1.35952457
33MP0001984_abnormal_olfaction1.35839593
34MP0005084_abnormal_gallbladder_morpholo1.35711295
35MP0000427_abnormal_hair_cycle1.35266740
36MP0001986_abnormal_taste_sensitivity1.34742526
37MP0001486_abnormal_startle_reflex1.33127205
38MP0008995_early_reproductive_senescence1.32304843
39MP0003121_genomic_imprinting1.31239302
40MP0008872_abnormal_physiological_respon1.30213123
41MP0009745_abnormal_behavioral_response1.30138662
42MP0005253_abnormal_eye_physiology1.27319952
43MP0001501_abnormal_sleep_pattern1.25646905
44MP0002653_abnormal_ependyma_morphology1.22272603
45MP0002282_abnormal_trachea_morphology1.20441673
46MP0001764_abnormal_homeostasis1.19581051
47MP0003646_muscle_fatigue1.13554108
48MP0000647_abnormal_sebaceous_gland1.12936871
49MP0002751_abnormal_autonomic_nervous1.12037198
50MP0002876_abnormal_thyroid_physiology1.12029705
51MP0002160_abnormal_reproductive_system1.07020394
52MP0000778_abnormal_nervous_system1.06285776
53MP0003136_yellow_coat_color1.05136547
54MP0006036_abnormal_mitochondrial_physio1.02454122
55MP0003786_premature_aging1.02067433
56MP0002837_dystrophic_cardiac_calcinosis1.01581728
57MP0002572_abnormal_emotion/affect_behav0.99500248
58MP0008775_abnormal_heart_ventricle0.99016246
59MP0002638_abnormal_pupillary_reflex0.96316329
60MP0001919_abnormal_reproductive_system0.95459792
61MP0009046_muscle_twitch0.94940535
62MP0002095_abnormal_skin_pigmentation0.94847706
63MP0002210_abnormal_sex_determination0.93749803
64MP0003011_delayed_dark_adaptation0.93019899
65MP0003186_abnormal_redox_activity0.91897517
66MP0005389_reproductive_system_phenotype0.90709018
67MP0002234_abnormal_pharynx_morphology0.90514168
68MP0002557_abnormal_social/conspecific_i0.90195869
69MP0003195_calcinosis0.88893483
70MP0005195_abnormal_posterior_eye0.88684692
71MP0000003_abnormal_adipose_tissue0.87687349
72MP0001929_abnormal_gametogenesis0.84717105
73MP0004145_abnormal_muscle_electrophysio0.84189251
74MP0005085_abnormal_gallbladder_physiolo0.84048502
75MP0005332_abnormal_amino_acid0.83322889
76MP0001963_abnormal_hearing_physiology0.83177807
77MP0001119_abnormal_female_reproductive0.82931434
78MP0002752_abnormal_somatic_nervous0.82715049
79MP0000653_abnormal_sex_gland0.81313122
80MP0001529_abnormal_vocalization0.81015792
81MP0005499_abnormal_olfactory_system0.80960341
82MP0005394_taste/olfaction_phenotype0.80960341
83MP0004742_abnormal_vestibular_system0.80607814
84MP0002733_abnormal_thermal_nociception0.78281521
85MP0003635_abnormal_synaptic_transmissio0.78203436
86MP0005410_abnormal_fertilization0.76849729
87MP0003755_abnormal_palate_morphology0.76255198
88MP0003698_abnormal_male_reproductive0.75763082
89MP0000026_abnormal_inner_ear0.75273042
90MP0003938_abnormal_ear_development0.75238185
91MP0000230_abnormal_systemic_arterial0.74975579
92MP0009764_decreased_sensitivity_to0.73882125
93MP0002233_abnormal_nose_morphology0.73260248
94MP0005386_behavior/neurological_phenoty0.72704591
95MP0004924_abnormal_behavior0.72704591
96MP0001970_abnormal_pain_threshold0.72190031
97MP0002184_abnormal_innervation0.72119355
98MP0001145_abnormal_male_reproductive0.72034110
99MP0001324_abnormal_eye_pigmentation0.71843947
100MP0002064_seizures0.71490849

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.07212134
2Molar tooth sign on MRI (HP:0002419)4.07212134
3Pancreatic cysts (HP:0001737)3.94518841
4Pancreatic fibrosis (HP:0100732)3.81235846
5Acute necrotizing encephalopathy (HP:0006965)3.57188605
6Increased CSF lactate (HP:0002490)3.37205416
7Mitochondrial inheritance (HP:0001427)3.37158970
8Nephronophthisis (HP:0000090)3.35761536
9True hermaphroditism (HP:0010459)3.21078035
10Hepatocellular necrosis (HP:0001404)3.14422554
11Progressive macrocephaly (HP:0004481)3.12194474
12Renal Fanconi syndrome (HP:0001994)3.10248119
13Abnormal mitochondria in muscle tissue (HP:0008316)3.06110892
14Acute encephalopathy (HP:0006846)2.99347641
15Abnormality of the renal medulla (HP:0100957)2.95590116
16Abnormal biliary tract physiology (HP:0012439)2.91901790
17Bile duct proliferation (HP:0001408)2.91901790
18Hepatic necrosis (HP:0002605)2.85118028
19Hypokalemic alkalosis (HP:0001949)2.74050721
20Increased hepatocellular lipid droplets (HP:0006565)2.70270140
21Abnormality of the renal cortex (HP:0011035)2.68045639
22Optic disc pallor (HP:0000543)2.66891361
23Metabolic alkalosis (HP:0200114)2.65553362
24Chronic hepatic failure (HP:0100626)2.62971461
25Abnormality of renal resorption (HP:0011038)2.60944997
26Type II lissencephaly (HP:0007260)2.59955307
273-Methylglutaconic aciduria (HP:0003535)2.58383226
28Anterior segment dysgenesis (HP:0007700)2.56838020
29Polyuria (HP:0000103)2.55688669
30Cystic liver disease (HP:0006706)2.52795623
31Progressive microcephaly (HP:0000253)2.51828622
32Renal cortical cysts (HP:0000803)2.50016208
33Lipid accumulation in hepatocytes (HP:0006561)2.44982836
34Increased serum pyruvate (HP:0003542)2.43010618
35Increased serum lactate (HP:0002151)2.40605407
36Methylmalonic acidemia (HP:0002912)2.35121528
37Hypoplasia of the fovea (HP:0007750)2.33417495
38Aplasia/Hypoplasia of the fovea (HP:0008060)2.33417495
39Congenital stationary night blindness (HP:0007642)2.29472838
40Neoplasm of the adrenal cortex (HP:0100641)2.28985272
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26733377
42Abnormality of alanine metabolism (HP:0010916)2.26733377
43Hyperalaninemia (HP:0003348)2.26733377
44Cerebral edema (HP:0002181)2.26590261
45Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24092089
46Absent speech (HP:0001344)2.20551862
47Abnormality of the fovea (HP:0000493)2.19316186
48Abolished electroretinogram (ERG) (HP:0000550)2.13788153
49Tubulointerstitial nephritis (HP:0001970)2.13472786
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12840487
51Abnormality of methionine metabolism (HP:0010901)2.12107100
52Optic nerve hypoplasia (HP:0000609)2.10570280
53Medial flaring of the eyebrow (HP:0010747)2.08816871
54Lactic acidosis (HP:0003128)2.05533144
55Elevated erythrocyte sedimentation rate (HP:0003565)2.05235607
56Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.04418694
57Anencephaly (HP:0002323)2.01005267
58Abnormal urine output (HP:0012590)2.00307190
59Abnormal number of erythroid precursors (HP:0012131)1.98150834
60Sclerocornea (HP:0000647)1.97880160
61Abnormality of macular pigmentation (HP:0008002)1.97223014
62Inability to walk (HP:0002540)1.97206365
63Abnormality of B cell number (HP:0010975)1.94404015
64Retinal dysplasia (HP:0007973)1.92976779
65Cerebellar dysplasia (HP:0007033)1.92925089
66Congenital hepatic fibrosis (HP:0002612)1.91912715
67Absent/shortened dynein arms (HP:0200106)1.91368118
68Dynein arm defect of respiratory motile cilia (HP:0012255)1.91368118
69B lymphocytopenia (HP:0010976)1.90425916
70Posterior subcapsular cataract (HP:0007787)1.90118507
71Patent foramen ovale (HP:0001655)1.89752333
72Attenuation of retinal blood vessels (HP:0007843)1.87419631
73Polydipsia (HP:0001959)1.86340667
74Abnormal drinking behavior (HP:0030082)1.86340667
75Postaxial foot polydactyly (HP:0001830)1.85955111
76Abnormality of cells of the erythroid lineage (HP:0012130)1.85192635
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.84978687
78Chorioretinal coloboma (HP:0000567)1.83814524
79Oligodactyly (hands) (HP:0001180)1.83592832
80Hyperaldosteronism (HP:0000859)1.82776519
81Pendular nystagmus (HP:0012043)1.81797065
82Abnormal rod and cone electroretinograms (HP:0008323)1.80205644
83Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80127310
84Thyroiditis (HP:0100646)1.79683241
85Narrow forehead (HP:0000341)1.79019586
86Asplenia (HP:0001746)1.78494925
87Leukodystrophy (HP:0002415)1.78391560
88Intestinal atresia (HP:0011100)1.77127922
89Increased corneal curvature (HP:0100692)1.76882672
90Keratoconus (HP:0000563)1.76882672
91Tubulointerstitial abnormality (HP:0001969)1.74606629
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.73201638
93Hyperventilation (HP:0002883)1.71991274
94Renal salt wasting (HP:0000127)1.70727431
95Sloping forehead (HP:0000340)1.70400901
96Microvesicular hepatic steatosis (HP:0001414)1.69954424
97Aplasia/Hypoplasia of the tongue (HP:0010295)1.69017784
98Congenital, generalized hypertrichosis (HP:0004540)1.68876332
99Rib fusion (HP:0000902)1.68337620
100Decreased central vision (HP:0007663)1.67027533

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.43683364
2CASK4.03199382
3BMPR1B3.95969542
4ZAK3.25036844
5NEK12.98717739
6MAP4K22.93013454
7FRK2.78007402
8WNK32.56974003
9NUAK12.43608851
10STK162.10695694
11TAOK21.98768503
12BCKDK1.91728225
13MUSK1.85553804
14TAOK31.80227522
15TNIK1.79617370
16MAP2K61.77441541
17TSSK61.75433438
18MAPK131.74207427
19WNK41.55472900
20TRIM281.46772005
21STK391.40646112
22ADRBK21.39326071
23PINK11.36070675
24ERBB31.34845645
25GRK11.34788264
26MST41.32098804
27VRK11.31840202
28MAP3K41.24747524
29MAP3K51.24602038
30CCNB11.22223170
31BCR1.15844948
32MINK11.09637911
33OXSR11.06637454
34DYRK21.02770247
35PAK30.95003010
36BMPR20.90540841
37MAP3K120.89378045
38WEE10.88299197
39TXK0.85510586
40PLK30.84946221
41PIK3CA0.83578478
42CDK190.81882493
43PRKCG0.79935204
44TEC0.78629673
45PRKCQ0.77764998
46NLK0.72606936
47MKNK20.71157089
48PIM10.70770698
49VRK20.67605222
50CSNK1G20.67365452
51SIK30.67083031
52TNK20.67068576
53PKN10.66966809
54IKBKB0.65586054
55CSNK1G30.64873631
56FGFR20.63383645
57NTRK20.63148884
58PHKG10.61728325
59PHKG20.61728325
60MKNK10.60936558
61EIF2AK30.59728259
62CSNK1G10.58157655
63MAP2K70.57667802
64SRPK10.57591112
65CSNK1A1L0.57048206
66FLT30.55112592
67DAPK30.54165365
68ITK0.54068228
69INSRR0.54061941
70ADRBK10.53934172
71PLK40.51065872
72PLK20.49442847
73PNCK0.47459030
74ATR0.47180434
75CDK80.45838314
76MARK10.45696997
77RPS6KA50.44764207
78PLK10.38538389
79TGFBR10.37859777
80PRKCE0.37240842
81STK38L0.37027077
82DAPK20.35919273
83MAPKAPK30.34071465
84NEK20.33695752
85GRK60.33610116
86CHEK20.31895846
87NME10.31705868
88CSNK2A10.31458643
89ATM0.31227957
90CSNK2A20.30570782
91NTRK30.28785443
92PRKACA0.28494711
93CSNK1D0.27242969
94TRPM70.27043366
95AKT30.26861627
96AURKB0.25940951
97RPS6KB10.25674861
98TIE10.25017241
99PRKCD0.24999758
100PRKCA0.23793832

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.66812886
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.51257422
3RNA polymerase_Homo sapiens_hsa030203.06143023
4Protein export_Homo sapiens_hsa030602.95490755
5Parkinsons disease_Homo sapiens_hsa050122.91215847
6Proteasome_Homo sapiens_hsa030502.64193936
7Ribosome_Homo sapiens_hsa030102.55833749
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.45437474
9Phototransduction_Homo sapiens_hsa047442.38875481
10Basal transcription factors_Homo sapiens_hsa030222.31430172
11Homologous recombination_Homo sapiens_hsa034402.22756717
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.15131272
13Butanoate metabolism_Homo sapiens_hsa006502.09064655
14Fanconi anemia pathway_Homo sapiens_hsa034602.08774203
15Huntingtons disease_Homo sapiens_hsa050162.04207360
16Selenocompound metabolism_Homo sapiens_hsa004501.86552768
17RNA degradation_Homo sapiens_hsa030181.84949210
18Alzheimers disease_Homo sapiens_hsa050101.77267630
19Base excision repair_Homo sapiens_hsa034101.72110613
20Collecting duct acid secretion_Homo sapiens_hsa049661.71190499
21Propanoate metabolism_Homo sapiens_hsa006401.69913835
22Asthma_Homo sapiens_hsa053101.65323986
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62373155
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61336459
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54675682
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52857928
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52161398
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31146171
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30987338
30Pyrimidine metabolism_Homo sapiens_hsa002401.27184214
31Cardiac muscle contraction_Homo sapiens_hsa042601.25237415
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.24985545
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22766762
34Linoleic acid metabolism_Homo sapiens_hsa005911.19356351
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.16311074
36Non-homologous end-joining_Homo sapiens_hsa034501.14237347
37Olfactory transduction_Homo sapiens_hsa047401.11170310
38RNA transport_Homo sapiens_hsa030131.10166327
39Purine metabolism_Homo sapiens_hsa002301.07450031
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04794810
41Peroxisome_Homo sapiens_hsa041461.03548118
42One carbon pool by folate_Homo sapiens_hsa006701.00767251
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.98593252
44Nicotine addiction_Homo sapiens_hsa050330.98582284
45Nitrogen metabolism_Homo sapiens_hsa009100.96335689
46Regulation of autophagy_Homo sapiens_hsa041400.95914165
47Spliceosome_Homo sapiens_hsa030400.93925674
48Type I diabetes mellitus_Homo sapiens_hsa049400.85416513
49Tryptophan metabolism_Homo sapiens_hsa003800.83710240
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81344594
51Caffeine metabolism_Homo sapiens_hsa002320.78368559
52Allograft rejection_Homo sapiens_hsa053300.77888363
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75580104
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.70247830
55Sulfur metabolism_Homo sapiens_hsa009200.68754804
56p53 signaling pathway_Homo sapiens_hsa041150.68661974
57Metabolic pathways_Homo sapiens_hsa011000.68362265
58Chemical carcinogenesis_Homo sapiens_hsa052040.68222633
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66159106
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.65744246
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64216400
62Autoimmune thyroid disease_Homo sapiens_hsa053200.64071385
63Glutathione metabolism_Homo sapiens_hsa004800.64021464
64Arachidonic acid metabolism_Homo sapiens_hsa005900.63735352
65Taste transduction_Homo sapiens_hsa047420.62959888
66Fat digestion and absorption_Homo sapiens_hsa049750.62326095
67Graft-versus-host disease_Homo sapiens_hsa053320.61396145
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59603028
69Primary immunodeficiency_Homo sapiens_hsa053400.58218083
70beta-Alanine metabolism_Homo sapiens_hsa004100.58181487
71Nucleotide excision repair_Homo sapiens_hsa034200.58091683
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57211934
73Morphine addiction_Homo sapiens_hsa050320.54874578
74Retinol metabolism_Homo sapiens_hsa008300.52949743
75Fatty acid elongation_Homo sapiens_hsa000620.52855684
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49866333
77Mismatch repair_Homo sapiens_hsa034300.49809518
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49236626
79Steroid biosynthesis_Homo sapiens_hsa001000.48110358
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47764208
81Dorso-ventral axis formation_Homo sapiens_hsa043200.47091589
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47033361
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.46914512
84Circadian rhythm_Homo sapiens_hsa047100.46710640
85Rheumatoid arthritis_Homo sapiens_hsa053230.45035052
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44642458
87Hedgehog signaling pathway_Homo sapiens_hsa043400.44384841
88Ether lipid metabolism_Homo sapiens_hsa005650.43474995
89Circadian entrainment_Homo sapiens_hsa047130.41252553
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39528671
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38509760
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37703398
93Insulin secretion_Homo sapiens_hsa049110.37537235
94Fatty acid degradation_Homo sapiens_hsa000710.36346362
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35731851
96Serotonergic synapse_Homo sapiens_hsa047260.34235247
97Cocaine addiction_Homo sapiens_hsa050300.31439507
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29439803
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27556386
100Systemic lupus erythematosus_Homo sapiens_hsa053220.25230313

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