ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.25114249
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.56959551
3	cytidine deamination (GO:0009972)	5.31509227
4	cytidine metabolic process (GO:0046087)	5.31509227
5	cytidine catabolic process (GO:0006216)	5.31509227
6	ATP synthesis coupled proton transport (GO:0015986)	5.29169021
7	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.29169021
8	ribosomal small subunit assembly (GO:0000028)	4.97631709
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.94603890
10	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.44833272
11	water-soluble vitamin biosynthetic process (GO:0042364)	4.30366729
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.28982508
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.28645925
14	protein complex biogenesis (GO:0070271)	3.86646831
15	negative regulation by host of viral transcription (GO:0043922)	3.79633257
16	cellular ketone body metabolic process (GO:0046950)	3.78691154
17	respiratory electron transport chain (GO:0022904)	3.77767764
18	electron transport chain (GO:0022900)	3.73972360
19	protein neddylation (GO:0045116)	3.68671495
20	platelet dense granule organization (GO:0060155)	3.43314087
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.42782903
22	NADH dehydrogenase complex assembly (GO:0010257)	3.42782903
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.42782903
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.42111458
25	proteasome assembly (GO:0043248)	3.40467297
26	maturation of SSU-rRNA (GO:0030490)	3.38658587
27	chaperone-mediated protein transport (GO:0072321)	3.36175102
28	protein polyglutamylation (GO:0018095)	3.35606541
29	ketone body metabolic process (GO:1902224)	3.34402238
30	rRNA modification (GO:0000154)	3.31744828
31	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.24239706
32	viral transcription (GO:0019083)	3.23095700
33	protein targeting to ER (GO:0045047)	3.22476593
34	translational termination (GO:0006415)	3.19070616
35	cotranslational protein targeting to membrane (GO:0006613)	3.17034730
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.15014793
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.15014793
38	aggressive behavior (GO:0002118)	3.13955140
39	aldehyde catabolic process (GO:0046185)	3.13304932
40	respiratory chain complex IV assembly (GO:0008535)	3.12536538
41	GPI anchor biosynthetic process (GO:0006506)	3.10702829
42	cytochrome complex assembly (GO:0017004)	3.09412863
43	protein localization to endoplasmic reticulum (GO:0070972)	3.07277997
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06153995
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.05832742
46	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.05377396
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.04671914
48	termination of RNA polymerase III transcription (GO:0006386)	3.04671914
49	ATP biosynthetic process (GO:0006754)	2.99719071
50	hydrogen ion transmembrane transport (GO:1902600)	2.98886776
51	regulation of regulatory T cell differentiation (GO:0045589)	2.98370895
52	GPI anchor metabolic process (GO:0006505)	2.97777411
53	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.91008484
54	DNA demethylation (GO:0080111)	2.90574084
55	regulation of chronic inflammatory response (GO:0002676)	2.90556203
56	translational elongation (GO:0006414)	2.87889997
57	pseudouridine synthesis (GO:0001522)	2.86389358
58	mannosylation (GO:0097502)	2.84704642
59	translation (GO:0006412)	2.83850127
60	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.83089255
61	negative regulation of T cell apoptotic process (GO:0070233)	2.82839954
62	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.82642356
63	proton transport (GO:0015992)	2.80268518
64	intracellular protein transmembrane import (GO:0044743)	2.80026329
65	regulation of activation of Janus kinase activity (GO:0010533)	2.79851786
66	regulation of cellular amino acid metabolic process (GO:0006521)	2.78571628
67	positive regulation of digestive system process (GO:0060456)	2.76754875
68	eosinophil chemotaxis (GO:0048245)	2.76731391
69	hydrogen transport (GO:0006818)	2.75831130
70	actin nucleation (GO:0045010)	2.71461049
71	sequestering of actin monomers (GO:0042989)	2.69770168
72	translational initiation (GO:0006413)	2.68756503
73	piRNA metabolic process (GO:0034587)	2.67481758
74	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.64738257
75	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.64484368
76	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.61459190
77	rRNA methylation (GO:0031167)	2.59356884
78	positive regulation of interleukin-17 production (GO:0032740)	2.58606781
79	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57813183
80	S-adenosylmethionine metabolic process (GO:0046500)	2.55402898
81	base-excision repair, AP site formation (GO:0006285)	2.54819711
82	synapsis (GO:0007129)	2.54249251
83	positive regulation of defense response to virus by host (GO:0002230)	2.54135754
84	response to pheromone (GO:0019236)	2.54107257
85	DNA dealkylation (GO:0035510)	2.51780805
86	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	2.51594222
87	positive regulation of prostaglandin secretion (GO:0032308)	2.51020063
88	eosinophil migration (GO:0072677)	2.49761634
89	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.48316953
90	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.47269900
91	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.42563921
92	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.41591815
93	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.41591815
94	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.41591815
95	protein peptidyl-prolyl isomerization (GO:0000413)	2.40804352
96	positive regulation of calcium-mediated signaling (GO:0050850)	2.38207743
97	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.37087860
98	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.35615644
99	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.35264208
100	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.35264208

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.86046860
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.53832894
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.59673028
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.33173849
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.26284118
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.22177314
7	VDR_22108803_ChIP-Seq_LS180_Human	2.98276451
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.83639790
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.67450039
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.62346214
11	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.33888700
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.33040054
13	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.31971251
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.18524951
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.14022538
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.13048351
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.12226090
18	FUS_26573619_Chip-Seq_HEK293_Human	2.01496049
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.01185747
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.89384639
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.72648490
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.71987827
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.70015788
24	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.68861951
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67466385
26	EWS_26573619_Chip-Seq_HEK293_Human	1.66789415
27	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.66376846
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.66241781
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.66201012
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60285739
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60114263
32	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.59448705
33	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.59448705
34	ELK1_19687146_ChIP-ChIP_HELA_Human	1.59030022
35	AR_20517297_ChIP-Seq_VCAP_Human	1.57201856
36	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.55589922
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.55090462
38	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.52744444
39	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.51800591
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.44971023
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.43944955
42	GATA3_26560356_Chip-Seq_TH2_Human	1.39041298
43	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.36626800
44	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.35256844
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34932876
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.31107916
47	GBX2_23144817_ChIP-Seq_PC3_Human	1.29654981
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29633325
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28271458
50	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.27717049
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24929870
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.24248238
53	P300_19829295_ChIP-Seq_ESCs_Human	1.24149815
54	ERG_20517297_ChIP-Seq_VCAP_Human	1.22892015
55	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21680603
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21680603
57	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.20218746
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20131149
59	CBP_20019798_ChIP-Seq_JUKART_Human	1.20131149
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.19794002
61	ER_23166858_ChIP-Seq_MCF-7_Human	1.17701614
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16607630
63	NCOR_22424771_ChIP-Seq_293T_Human	1.16320477
64	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15540625
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14642228
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14074433
67	MYB_26560356_Chip-Seq_TH2_Human	1.13520395
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.12041622
69	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08727291
70	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08376251
71	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07414248
72	PHF8_20622853_ChIP-Seq_HELA_Human	1.06372862
73	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.04233793
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.04182891
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.03660189
76	BCAT_22108803_ChIP-Seq_LS180_Human	1.03622593
77	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.02464002
78	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02314670
79	RBPJ_21746931_ChIP-Seq_IB4_Human	1.01914942
80	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.00834227
81	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00833687
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00336927
83	HTT_18923047_ChIP-ChIP_STHdh_Human	0.99898503
84	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.98719082
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.98451518
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96962823
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96834374
88	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.96826157
89	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95382291
90	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.95128279
91	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94844663
92	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94533469
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.93950279
94	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93662197
95	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92116726
96	GATA3_27048872_Chip-Seq_THYMUS_Human	0.91631953
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90761754
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.90186410
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.89331588
100	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.88863264

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.48098079
2	MP0005671_abnormal_response_to	3.13458463
3	MP0002837_dystrophic_cardiac_calcinosis	2.74712956
4	MP0002876_abnormal_thyroid_physiology	2.55897024
5	MP0003195_calcinosis	2.39226843
6	MP0005645_abnormal_hypothalamus_physiol	2.36767811
7	MP0006072_abnormal_retinal_apoptosis	2.32142807
8	MP0005084_abnormal_gallbladder_morpholo	2.28888926
9	MP0003786_premature_aging	2.23537249
10	MP0001835_abnormal_antigen_presentation	2.20358469
11	MP0003283_abnormal_digestive_organ	2.17184789
12	MP0006292_abnormal_olfactory_placode	2.08921071
13	MP0005646_abnormal_pituitary_gland	2.08301344
14	MP0005377_hearing/vestibular/ear_phenot	1.96891716
15	MP0003878_abnormal_ear_physiology	1.96891716
16	MP0005551_abnormal_eye_electrophysiolog	1.95440721
17	MP0001968_abnormal_touch/_nociception	1.94360036
18	MP0002163_abnormal_gland_morphology	1.90533824
19	MP0005379_endocrine/exocrine_gland_phen	1.83364975
20	MP0008872_abnormal_physiological_respon	1.82823041
21	MP0009785_altered_susceptibility_to	1.77290044
22	MP0004147_increased_porphyrin_level	1.76826409
23	MP0001188_hyperpigmentation	1.76710092
24	MP0000013_abnormal_adipose_tissue	1.76306226
25	MP0008877_abnormal_DNA_methylation	1.76280335
26	MP0002160_abnormal_reproductive_system	1.73368770
27	MP0000372_irregular_coat_pigmentation	1.72568134
28	MP0008875_abnormal_xenobiotic_pharmacok	1.72441857
29	MP0003252_abnormal_bile_duct	1.66991122
30	MP0002166_altered_tumor_susceptibility	1.65557588
31	MP0002102_abnormal_ear_morphology	1.61783610
32	MP0002148_abnormal_hypersensitivity_rea	1.54446500
33	MP0005075_abnormal_melanosome_morpholog	1.52804907
34	MP0001905_abnormal_dopamine_level	1.52394775
35	MP0002006_tumorigenesis	1.52047852
36	MP0005389_reproductive_system_phenotype	1.48646199
37	MP0002277_abnormal_respiratory_mucosa	1.42653485
38	MP0008058_abnormal_DNA_repair	1.42245594
39	MP0003763_abnormal_thymus_physiology	1.39381272
40	MP0001501_abnormal_sleep_pattern	1.37443433
41	MP0002736_abnormal_nociception_after	1.33460316
42	MP0002693_abnormal_pancreas_physiology	1.31623789
43	MP0005636_abnormal_mineral_homeostasis	1.29460133
44	MP0008995_early_reproductive_senescence	1.28740663
45	MP0004885_abnormal_endolymph	1.24812082
46	MP0009333_abnormal_splenocyte_physiolog	1.23844812
47	MP0005253_abnormal_eye_physiology	1.22010201
48	MP0002138_abnormal_hepatobiliary_system	1.21986606
49	MP0001485_abnormal_pinna_reflex	1.20327027
50	MP0001800_abnormal_humoral_immune	1.20231524
51	MP0003567_abnormal_fetal_cardiomyocyte	1.17526450
52	MP0001765_abnormal_ion_homeostasis	1.17323471
53	MP0001873_stomach_inflammation	1.16756794
54	MP0000685_abnormal_immune_system	1.15590832
55	MP0005332_abnormal_amino_acid	1.14711443
56	MP0005000_abnormal_immune_tolerance	1.12070744
57	MP0002234_abnormal_pharynx_morphology	1.11337607
58	MP0005174_abnormal_tail_pigmentation	1.07731120
59	MP0005387_immune_system_phenotype	1.07644056
60	MP0001790_abnormal_immune_system	1.07644056
61	MP0005410_abnormal_fertilization	1.05073455
62	MP0003136_yellow_coat_color	1.04933560
63	MP0002723_abnormal_immune_serum	1.02625319
64	MP0002272_abnormal_nervous_system	1.02587569
65	MP0006036_abnormal_mitochondrial_physio	1.00861143
66	MP0002420_abnormal_adaptive_immunity	0.98490293
67	MP0001661_extended_life_span	0.96765540
68	MP0003646_muscle_fatigue	0.96435243
69	MP0001819_abnormal_immune_cell	0.95329923
70	MP0002132_abnormal_respiratory_system	0.94610676
71	MP0003186_abnormal_redox_activity	0.94090849
72	MP0000569_abnormal_digit_pigmentation	0.93651072
73	MP0001664_abnormal_digestion	0.92220152
74	MP0000230_abnormal_systemic_arterial	0.91035629
75	MP0001764_abnormal_homeostasis	0.90769425
76	MP0002638_abnormal_pupillary_reflex	0.90354148
77	MP0005085_abnormal_gallbladder_physiolo	0.88895571
78	MP0000631_abnormal_neuroendocrine_gland	0.88662046
79	MP0009745_abnormal_behavioral_response	0.87893480
80	MP0006082_CNS_inflammation	0.84981988
81	MP0001919_abnormal_reproductive_system	0.80796754
82	MP0006276_abnormal_autonomic_nervous	0.80609858
83	MP0002405_respiratory_system_inflammati	0.79027158
84	MP0003806_abnormal_nucleotide_metabolis	0.78784132
85	MP0004215_abnormal_myocardial_fiber	0.78612800
86	MP0002095_abnormal_skin_pigmentation	0.78550997
87	MP0002139_abnormal_hepatobiliary_system	0.77282343
88	MP0010386_abnormal_urinary_bladder	0.77221135
89	MP0002398_abnormal_bone_marrow	0.75549706
90	MP0002933_joint_inflammation	0.75312792
91	MP0005025_abnormal_response_to	0.75254555
92	MP0004142_abnormal_muscle_tone	0.75198092
93	MP0002938_white_spotting	0.74416569
94	MP0004145_abnormal_muscle_electrophysio	0.74354856
95	MP0000716_abnormal_immune_system	0.74238581
96	MP0001502_abnormal_circadian_rhythm	0.73904255
97	MP0003718_maternal_effect	0.73479957
98	MP0003638_abnormal_response/metabolism_	0.73356954
99	MP0008469_abnormal_protein_level	0.72755566
100	MP0001944_abnormal_pancreas_morphology	0.71622466

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.00803211
2	Mitochondrial inheritance (HP:0001427)	3.97911999
3	Acute necrotizing encephalopathy (HP:0006965)	3.97206458
4	Aplastic anemia (HP:0001915)	3.81095022
5	Renal Fanconi syndrome (HP:0001994)	3.67403495
6	Increased hepatocellular lipid droplets (HP:0006565)	3.65809470
7	Lipid accumulation in hepatocytes (HP:0006561)	3.55258399
8	3-Methylglutaconic aciduria (HP:0003535)	3.53419868
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.44094287
10	Increased CSF lactate (HP:0002490)	3.43174774
11	Hepatocellular necrosis (HP:0001404)	3.39464988
12	Cerebellar dysplasia (HP:0007033)	3.37754601
13	Progressive macrocephaly (HP:0004481)	3.36647012
14	Congenital stationary night blindness (HP:0007642)	3.34044487
15	Abolished electroretinogram (ERG) (HP:0000550)	3.29027904
16	Abnormality of midbrain morphology (HP:0002418)	3.20002001
17	Molar tooth sign on MRI (HP:0002419)	3.20002001
18	Acute encephalopathy (HP:0006846)	3.16708687
19	Hypoproteinemia (HP:0003075)	3.15591410
20	Hepatic necrosis (HP:0002605)	3.13669912
21	IgG deficiency (HP:0004315)	3.09796699
22	T lymphocytopenia (HP:0005403)	3.01155166
23	Methylmalonic acidemia (HP:0002912)	2.99082056
24	Pancreatic cysts (HP:0001737)	2.98887374
25	Severe combined immunodeficiency (HP:0004430)	2.98349790
26	Abnormal rod and cone electroretinograms (HP:0008323)	2.93440185
27	Increased intramyocellular lipid droplets (HP:0012240)	2.91359399
28	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.90224977
29	True hermaphroditism (HP:0010459)	2.87360564
30	Hypoplasia of the pons (HP:0012110)	2.86179225
31	Nephronophthisis (HP:0000090)	2.83045058
32	Pancreatic fibrosis (HP:0100732)	2.78003127
33	Abnormality of T cell number (HP:0011839)	2.75472297
34	Thyroiditis (HP:0100646)	2.75000341
35	Attenuation of retinal blood vessels (HP:0007843)	2.71046770
36	Elevated erythrocyte sedimentation rate (HP:0003565)	2.70793983
37	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.69823314
38	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.69823314
39	Cerebral edema (HP:0002181)	2.64633939
40	Glycosuria (HP:0003076)	2.59957770
41	Abnormality of urine glucose concentration (HP:0011016)	2.59957770
42	Abnormality of the pons (HP:0007361)	2.59410652
43	Retinal dysplasia (HP:0007973)	2.55592570
44	Generalized aminoaciduria (HP:0002909)	2.53278077
45	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.51405343
46	Methylmalonic aciduria (HP:0012120)	2.49526230
47	Optic disc pallor (HP:0000543)	2.48353892
48	Increased muscle lipid content (HP:0009058)	2.47628355
49	Exertional dyspnea (HP:0002875)	2.45920776
50	Reduced antithrombin III activity (HP:0001976)	2.45145017
51	Abnormality of renal resorption (HP:0011038)	2.36434045
52	Abnormality of vitamin B metabolism (HP:0004340)	2.35428092
53	Abnormal drinking behavior (HP:0030082)	2.31192378
54	Polydipsia (HP:0001959)	2.31192378
55	Retinal atrophy (HP:0001105)	2.27304906
56	Decreased central vision (HP:0007663)	2.24301358
57	Respiratory difficulties (HP:0002880)	2.24262376
58	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.23726647
59	Abnormality of alanine metabolism (HP:0010916)	2.23726647
60	Hyperalaninemia (HP:0003348)	2.23726647
61	Abnormality of the renal medulla (HP:0100957)	2.20154325
62	Pancytopenia (HP:0001876)	2.15706385
63	Abnormality of B cell number (HP:0010975)	2.14430727
64	Renal cortical cysts (HP:0000803)	2.13738992
65	Abnormality of the renal cortex (HP:0011035)	2.13654455
66	B lymphocytopenia (HP:0010976)	2.09773350
67	Congenital, generalized hypertrichosis (HP:0004540)	2.08402793
68	Hypoalbuminemia (HP:0003073)	2.08392217
69	Abnormal albumin level (HP:0012116)	2.08392217
70	Increased serum lactate (HP:0002151)	2.08319940
71	Combined immunodeficiency (HP:0005387)	2.07697538
72	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.06590077
73	Lactic acidosis (HP:0003128)	2.05676956
74	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.03438661
75	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.03112900
76	Dicarboxylic aciduria (HP:0003215)	2.03112900
77	Abnormal number of erythroid precursors (HP:0012131)	2.02646885
78	Abnormality of eosinophils (HP:0001879)	2.02574684
79	Lethargy (HP:0001254)	2.01117665
80	Abnormal protein glycosylation (HP:0012346)	2.00109284
81	Abnormal glycosylation (HP:0012345)	2.00109284
82	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.00109284
83	Abnormal protein N-linked glycosylation (HP:0012347)	2.00109284
84	Abnormality of cells of the erythroid lineage (HP:0012130)	1.97894578
85	Intestinal atresia (HP:0011100)	1.92457998
86	Abnormality of T cells (HP:0002843)	1.91496842
87	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.91367419
88	Respiratory failure (HP:0002878)	1.89123495
89	Stomatitis (HP:0010280)	1.88984772
90	Delayed CNS myelination (HP:0002188)	1.88170228
91	Increased IgM level (HP:0003496)	1.87183480
92	Pendular nystagmus (HP:0012043)	1.86812420
93	Hypothermia (HP:0002045)	1.84057167
94	Abnormality of fatty-acid metabolism (HP:0004359)	1.81864252
95	Leukodystrophy (HP:0002415)	1.81273501
96	Eosinophilia (HP:0001880)	1.80935678
97	Hypoglycemic seizures (HP:0002173)	1.78702520
98	Ketosis (HP:0001946)	1.78151450
99	Large for gestational age (HP:0001520)	1.77429645
100	Type I transferrin isoform profile (HP:0003642)	1.74069646

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.70831915
2	ZAK	3.50834164
3	MAP4K2	3.28625479
4	KDR	3.10775358
5	GRK1	2.78047224
6	VRK2	2.73448208
7	ADRBK2	2.51578469
8	TLK1	2.24325216
9	BCKDK	2.17663045
10	SCYL2	2.17587593
11	INSRR	2.16637418
12	FRK	2.11805509
13	BMPR2	2.03693251
14	MAP3K12	1.94560679
15	WNK3	1.86390172
16	CDK19	1.85767837
17	PINK1	1.78077338
18	TAOK3	1.77402443
19	WNK4	1.72740219
20	VRK1	1.67738973
21	NUAK1	1.63035974
22	MST4	1.62392056
23	MYLK	1.54702509
24	ITK	1.45511287
25	STK16	1.44194697
26	TIE1	1.33266837
27	MAP4K1	1.28733003
28	DAPK2	1.28172996
29	TEC	1.25049262
30	PIK3CG	1.22375650
31	NLK	1.21340231
32	MARK3	1.19718867
33	KIT	1.17175528
34	OXSR1	1.17004135
35	AKT3	1.13279557
36	EIF2AK3	1.12407890
37	PRKCQ	1.10522651
38	MAP2K6	1.02619772
39	TESK2	0.95729751
40	FLT3	0.94846335
41	GRK7	0.92743694
42	PRKG2	0.91005610
43	NME1	0.90479083
44	STK39	0.90018249
45	TRPM7	0.87627458
46	IKBKB	0.86423610
47	PLK4	0.86274311
48	BUB1	0.81032110
49	BMPR1B	0.79066928
50	ERBB3	0.77818596
51	MAPKAPK3	0.77799810
52	STK10	0.77446545
53	RPS6KA5	0.76864022
54	SYK	0.76711155
55	TAF1	0.76160582
56	TSSK6	0.75575220
57	PHKG2	0.75222043
58	PHKG1	0.75222043
59	LIMK1	0.75170469
60	ZAP70	0.73786854
61	DAPK1	0.72600692
62	PRKCE	0.71564213
63	IKBKE	0.71129268
64	PIM1	0.69937009
65	BRSK2	0.67983878
66	PRKCH	0.66099033
67	CSNK1G1	0.64161702
68	TNK2	0.64102892
69	PLK3	0.63466553
70	ADRBK1	0.63454300
71	PLK2	0.61136319
72	LCK	0.60837412
73	DAPK3	0.59512305
74	GRK6	0.56514436
75	PASK	0.56286440
76	TNIK	0.55679052
77	PTK2B	0.53944888
78	PBK	0.53268820
79	DYRK2	0.51517934
80	MKNK1	0.51400979
81	CSNK2A2	0.50159629
82	GRK5	0.47763589
83	TGFBR1	0.45475921
84	OBSCN	0.45389344
85	PRKACA	0.41480770
86	BTK	0.41298296
87	CSF1R	0.40369732
88	CSNK1G3	0.40244968
89	LYN	0.39417823
90	FES	0.38969095
91	PRKCG	0.38227209
92	PRKCA	0.38116982
93	TESK1	0.36762098
94	STK11	0.34169145
95	CSNK1A1	0.33922533
96	MAPKAPK5	0.33107578
97	MAPK13	0.32868154
98	STK4	0.32643357
99	PAK3	0.31200742
100	CAMK2A	0.30777587

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.79306220
2	Proteasome_Homo sapiens_hsa03050	3.65526773
3	Ribosome_Homo sapiens_hsa03010	3.37534200
4	Parkinsons disease_Homo sapiens_hsa05012	2.96305931
5	Protein export_Homo sapiens_hsa03060	2.88487632
6	Primary immunodeficiency_Homo sapiens_hsa05340	2.84575816
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43662974
8	RNA polymerase_Homo sapiens_hsa03020	2.32688783
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.20991911
10	Type I diabetes mellitus_Homo sapiens_hsa04940	2.19221003
11	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.06426968
12	Alzheimers disease_Homo sapiens_hsa05010	2.02110544
13	Allograft rejection_Homo sapiens_hsa05330	1.99912496
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.99342589
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.95825529
16	Huntingtons disease_Homo sapiens_hsa05016	1.82912835
17	Asthma_Homo sapiens_hsa05310	1.82365920
18	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.64508859
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63892486
20	One carbon pool by folate_Homo sapiens_hsa00670	1.62657708
21	Phototransduction_Homo sapiens_hsa04744	1.61869002
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56113697
23	Butanoate metabolism_Homo sapiens_hsa00650	1.52144870
24	Sulfur metabolism_Homo sapiens_hsa00920	1.50747775
25	Antigen processing and presentation_Homo sapiens_hsa04612	1.47062779
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.45579413
27	Homologous recombination_Homo sapiens_hsa03440	1.35188961
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.34596375
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.31712224
30	RNA degradation_Homo sapiens_hsa03018	1.30307024
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.30213234
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26207023
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24042005
34	Peroxisome_Homo sapiens_hsa04146	1.16498579
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.10167733
36	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.09165329
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.03995092
38	Propanoate metabolism_Homo sapiens_hsa00640	1.02212852
39	Purine metabolism_Homo sapiens_hsa00230	1.00862887
40	Tryptophan metabolism_Homo sapiens_hsa00380	0.98943094
41	Caffeine metabolism_Homo sapiens_hsa00232	0.97946662
42	Selenocompound metabolism_Homo sapiens_hsa00450	0.96742916
43	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96638615
44	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95714103
45	Olfactory transduction_Homo sapiens_hsa04740	0.94907298
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94370021
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92371471
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91899735
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90890403
50	Pyrimidine metabolism_Homo sapiens_hsa00240	0.90366872
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87748118
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86684877
53	Retinol metabolism_Homo sapiens_hsa00830	0.83854427
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.83836318
55	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.80278835
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.80017271
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78603131
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76211194
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75203180
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73683721
61	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.72238875
62	Basal transcription factors_Homo sapiens_hsa03022	0.71020341
63	Metabolic pathways_Homo sapiens_hsa01100	0.70590452
64	RNA transport_Homo sapiens_hsa03013	0.67562896
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.66910532
66	Glutathione metabolism_Homo sapiens_hsa00480	0.65558287
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.65272775
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.63830191
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.60836058
70	Spliceosome_Homo sapiens_hsa03040	0.59804545
71	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.58247428
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.58040820
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58031272
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.55562723
75	Mismatch repair_Homo sapiens_hsa03430	0.55309365
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.53489152
77	Salivary secretion_Homo sapiens_hsa04970	0.53262600
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.53016938
79	Regulation of autophagy_Homo sapiens_hsa04140	0.51459932
80	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45613717
81	DNA replication_Homo sapiens_hsa03030	0.45194807
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.42895725
83	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42786538
84	Fatty acid elongation_Homo sapiens_hsa00062	0.42540041
85	Insulin secretion_Homo sapiens_hsa04911	0.41697115
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.41539304
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41318198
88	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.40444108
89	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.38673680
90	Fat digestion and absorption_Homo sapiens_hsa04975	0.38023746
91	Mineral absorption_Homo sapiens_hsa04978	0.36407853
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.35990711
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34173432
94	Base excision repair_Homo sapiens_hsa03410	0.31114929
95	Folate biosynthesis_Homo sapiens_hsa00790	0.30218109
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.29355728
97	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28580259
98	Measles_Homo sapiens_hsa05162	0.28417260
99	Renin secretion_Homo sapiens_hsa04924	0.27184111
100	Circadian entrainment_Homo sapiens_hsa04713	0.27003509

PABPC1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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