PABPC1P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mating behavior (GO:0007617)7.60613536
2hydrogen peroxide biosynthetic process (GO:0050665)6.99730806
3superoxide anion generation (GO:0042554)6.96135373
4Rap protein signal transduction (GO:0032486)6.22590156
5reactive oxygen species biosynthetic process (GO:1903409)6.22314356
6respiratory burst (GO:0045730)5.39036312
7genitalia morphogenesis (GO:0035112)5.38931567
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36405311
9phagocytosis, recognition (GO:0006910)4.96752434
10regulation of interferon-beta biosynthetic process (GO:0045357)4.65643813
11positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.63755499
12negative regulation of T-helper cell differentiation (GO:0045623)4.62950187
13negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.62950187
14negative regulation of type 2 immune response (GO:0002829)4.35077332
15negative regulation of immunoglobulin mediated immune response (GO:0002890)4.19248830
16negative regulation of B cell mediated immunity (GO:0002713)4.19248830
17germinal center formation (GO:0002467)4.16322706
18positive regulation of mast cell activation (GO:0033005)4.13425814
19positive regulation of RNA splicing (GO:0033120)4.12911486
20proline transport (GO:0015824)4.02369346
21positive regulation of mast cell activation involved in immune response (GO:0033008)3.93442873
22positive regulation of mast cell degranulation (GO:0043306)3.93442873
23fatty acid elongation (GO:0030497)3.90492333
24negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.88074211
25positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.76411837
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.75955620
27positive regulation of granulocyte differentiation (GO:0030854)3.53620731
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.51815090
29monoubiquitinated protein deubiquitination (GO:0035520)3.50295051
30regulation of hypersensitivity (GO:0002883)3.42020422
31regulation of memory T cell differentiation (GO:0043380)3.40866998
32histamine secretion (GO:0001821)3.37786569
33signal peptide processing (GO:0006465)3.37466578
34inner cell mass cell proliferation (GO:0001833)3.37047263
35histone H2B ubiquitination (GO:0033523)3.35819361
36growth hormone receptor signaling pathway (GO:0060396)3.30655670
37Arp2/3 complex-mediated actin nucleation (GO:0034314)3.28312157
38negative regulation of DNA recombination (GO:0045910)3.27161057
39actin nucleation (GO:0045010)3.26862081
40microglial cell activation (GO:0001774)3.26833743
41detection of molecule of bacterial origin (GO:0032490)3.25948204
42innate immune response in mucosa (GO:0002227)3.21165926
43hepatocyte apoptotic process (GO:0097284)3.19940884
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.18847535
45N-acetylneuraminate metabolic process (GO:0006054)3.17615439
46positive regulation of cellular amide metabolic process (GO:0034250)3.17445112
47homeostasis of number of cells within a tissue (GO:0048873)3.15585217
48regulation of mast cell activation (GO:0033003)3.14612264
49cell wall macromolecule catabolic process (GO:0016998)3.14490778
50negative regulation of alpha-beta T cell differentiation (GO:0046639)3.12834127
51positive regulation of developmental pigmentation (GO:0048087)3.10067649
52regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08171024
53regulation of myeloid leukocyte mediated immunity (GO:0002886)3.07282112
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.06922742
55positive regulation by organism of defense response of other organism involved in symbiotic interact3.06922742
56modulation by symbiont of host immune response (GO:0052553)3.06922742
57positive regulation by symbiont of host defense response (GO:0052509)3.06922742
58modulation by symbiont of host defense response (GO:0052031)3.06922742
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.06922742
60purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.06565977
61alanine transport (GO:0032328)3.02808778
62negative regulation of lymphocyte mediated immunity (GO:0002707)2.99940723
63detection of other organism (GO:0098543)2.99448484
64negative regulation of adaptive immune response (GO:0002820)2.96621892
65regulation of mast cell activation involved in immune response (GO:0033006)2.93243589
66regulation of mast cell degranulation (GO:0043304)2.91330119
67myeloid leukocyte mediated immunity (GO:0002444)2.91021977
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90379664
69positive regulation of leukocyte degranulation (GO:0043302)2.90359681
70cellular response to growth hormone stimulus (GO:0071378)2.89674006
71regulation of T cell tolerance induction (GO:0002664)2.88888786
72antigen processing and presentation of endogenous antigen (GO:0019883)2.88629241
73negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87602040
74cellular response to thyroid hormone stimulus (GO:0097067)2.87487200
75protein prenylation (GO:0018342)2.86113064
76prenylation (GO:0097354)2.86113064
77phagosome maturation (GO:0090382)2.85655319
78protein import into peroxisome matrix (GO:0016558)2.83885069
79positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82986011
80regulation of tolerance induction (GO:0002643)2.82058866
81negative regulation of viral entry into host cell (GO:0046597)2.79839198
82indole-containing compound catabolic process (GO:0042436)2.76602987
83indolalkylamine catabolic process (GO:0046218)2.76602987
84tryptophan catabolic process (GO:0006569)2.76602987
85mucosal immune response (GO:0002385)2.73250018
86detection of external biotic stimulus (GO:0098581)2.71167059
87macrophage activation (GO:0042116)2.70337029
88regulation of hematopoietic progenitor cell differentiation (GO:1901532)2.68875361
89synapsis (GO:0007129)2.68779477
90regulation of B cell mediated immunity (GO:0002712)2.68222260
91antigen processing and presentation via MHC class Ib (GO:0002475)2.67723548
92regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.66597419
93regulation of B cell apoptotic process (GO:0002902)2.65228246
94regulation of isotype switching to IgG isotypes (GO:0048302)2.64836425
95superoxide metabolic process (GO:0006801)2.63245684
96organ or tissue specific immune response (GO:0002251)2.60810148
97histamine transport (GO:0051608)2.60219319
98regulation of germinal center formation (GO:0002634)2.58993498
99negative regulation of defense response to virus (GO:0050687)2.58725962
100resolution of meiotic recombination intermediates (GO:0000712)2.56739284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.77985540
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.17835383
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.00866679
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.63217222
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38474959
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.85555290
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.75001031
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64993209
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.59445354
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52226541
11ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.49413409
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27440988
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23990632
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21889851
15ZNF274_21170338_ChIP-Seq_K562_Hela2.20295649
16TAF15_26573619_Chip-Seq_HEK293_Human2.05642243
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.03989080
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91428459
19GATA3_26560356_Chip-Seq_TH2_Human1.86250021
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78533761
21VDR_22108803_ChIP-Seq_LS180_Human1.77394159
22RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.76786241
23HTT_18923047_ChIP-ChIP_STHdh_Human1.69986641
24TP53_16413492_ChIP-PET_HCT116_Human1.60667695
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58890496
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55582424
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45489076
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43167500
29GATA3_26560356_Chip-Seq_TH1_Human1.42227777
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40510053
31P300_19829295_ChIP-Seq_ESCs_Human1.40356161
32RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38715446
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.38309479
34SPI1_23127762_ChIP-Seq_K562_Human1.38307752
35EWS_26573619_Chip-Seq_HEK293_Human1.37996522
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37951530
37MYB_26560356_Chip-Seq_TH2_Human1.37787942
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35706745
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35650126
40SPI1_23547873_ChIP-Seq_NB4_Human1.35643530
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34126649
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.32823172
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32571357
44ER_23166858_ChIP-Seq_MCF-7_Human1.30156443
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28761390
46TP53_22573176_ChIP-Seq_HFKS_Human1.24202965
47CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22883588
48GATA3_27048872_Chip-Seq_THYMUS_Human1.22345561
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.19786408
50ETS1_22383799_ChIP-Seq_G1ME_Mouse1.19760923
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.19175638
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18660401
53GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.17692889
54FLI1_21867929_ChIP-Seq_TH2_Mouse1.16976595
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16606380
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15264341
57VDR_24787735_ChIP-Seq_THP-1_Human1.15229657
58CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14355225
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14218002
60TFEB_21752829_ChIP-Seq_HELA_Human1.13728278
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.12101148
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11565268
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11565268
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.09092156
65EZH2_22144423_ChIP-Seq_EOC_Human1.08409933
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07788597
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07003998
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06521296
69OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06498993
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04301383
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04111782
72GATA1_22025678_ChIP-Seq_K562_Human0.99191626
73E2F4_17652178_ChIP-ChIP_JURKAT_Human0.98997735
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98997582
75CIITA_25753668_ChIP-Seq_RAJI_Human0.98469508
76PRDM14_20953172_ChIP-Seq_ESCs_Human0.98149249
77TCF4_22108803_ChIP-Seq_LS180_Human0.97120526
78BCAT_22108803_ChIP-Seq_LS180_Human0.96910964
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96174089
80FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95719525
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.95312727
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94836048
83GATA1_19941826_ChIP-Seq_K562_Human0.94596602
84PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94391729
85TCF4_23295773_ChIP-Seq_U87_Human0.94065931
86CBP_20019798_ChIP-Seq_JUKART_Human0.94063051
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94063051
88CRX_20693478_ChIP-Seq_RETINA_Mouse0.92343110
89SALL4_22934838_ChIP-ChIP_CD34+_Human0.91640262
90RUNX1_22412390_ChIP-Seq_EML_Mouse0.90280323
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88579200
92ELK1_19687146_ChIP-ChIP_HELA_Human0.87893958
93NFE2_27457419_Chip-Seq_LIVER_Mouse0.87640886
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87318623
95VDR_23849224_ChIP-Seq_CD4+_Human0.85624974
96MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85610319
97STAT3_23295773_ChIP-Seq_U87_Human0.85578774
98PU_27001747_Chip-Seq_BMDM_Mouse0.85042916
99SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84523124
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84502260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.20126766
2MP0000569_abnormal_digit_pigmentation4.18831027
3MP0008057_abnormal_DNA_replication3.95337843
4MP0002138_abnormal_hepatobiliary_system3.54053562
5MP0003724_increased_susceptibility_to3.47937038
6MP0004381_abnormal_hair_follicle3.44725445
7MP0003787_abnormal_imprinting3.23862990
8MP0009785_altered_susceptibility_to2.93765841
9MP0001835_abnormal_antigen_presentation2.64258094
10MP0003183_abnormal_peptide_metabolism2.38748099
11MP0002254_reproductive_system_inflammat2.37358396
12MP0005075_abnormal_melanosome_morpholog2.35057541
13MP0006082_CNS_inflammation2.34234592
14MP0005310_abnormal_salivary_gland2.32685917
15MP0002166_altered_tumor_susceptibility2.29736506
16MP0001502_abnormal_circadian_rhythm2.28325919
17MP0000685_abnormal_immune_system2.17604433
18MP0001790_abnormal_immune_system1.96267516
19MP0005387_immune_system_phenotype1.96267516
20MP0001800_abnormal_humoral_immune1.83895800
21MP0000427_abnormal_hair_cycle1.80314661
22MP0004043_abnormal_pH_regulation1.77800885
23MP0003300_gastrointestinal_ulcer1.68162221
24MP0002419_abnormal_innate_immunity1.59788056
25MP0002006_tumorigenesis1.58948716
26MP0002723_abnormal_immune_serum1.58921603
27MP0005025_abnormal_response_to1.57097721
28MP0002452_abnormal_antigen_presenting1.52629727
29MP0005167_abnormal_blood-brain_barrier1.49802242
30MP0001853_heart_inflammation1.48075797
31MP0002420_abnormal_adaptive_immunity1.46475195
32MP0005000_abnormal_immune_tolerance1.45886805
33MP0001819_abnormal_immune_cell1.43122630
34MP0008875_abnormal_xenobiotic_pharmacok1.40004104
35MP0008775_abnormal_heart_ventricle1.36785322
36MP0002837_dystrophic_cardiac_calcinosis1.35996749
37MP0000371_diluted_coat_color1.35607797
38MP0004147_increased_porphyrin_level1.32443775
39MP0003690_abnormal_glial_cell1.32024230
40MP0005671_abnormal_response_to1.30573638
41MP0003195_calcinosis1.30071463
42MP0002405_respiratory_system_inflammati1.29438097
43MP0004215_abnormal_myocardial_fiber1.28840714
44MP0004947_skin_inflammation1.28828801
45MP0003646_muscle_fatigue1.24969627
46MP0001845_abnormal_inflammatory_respons1.24686576
47MP0000013_abnormal_adipose_tissue1.21655014
48MP0001542_abnormal_bone_strength1.20683005
49MP0002148_abnormal_hypersensitivity_rea1.20532190
50MP0005646_abnormal_pituitary_gland1.20521898
51MP0004130_abnormal_muscle_cell1.20398843
52MP0009333_abnormal_splenocyte_physiolog1.18110480
53MP0003763_abnormal_thymus_physiology1.16693231
54MP0000858_altered_metastatic_potential1.14076104
55MP0002822_catalepsy1.11301161
56MP0000716_abnormal_immune_system1.04958721
57MP0008260_abnormal_autophagy1.04834856
58MP0003828_pulmonary_edema1.04206494
59MP0005464_abnormal_platelet_physiology1.04170515
60MP0005058_abnormal_lysosome_morphology1.01996343
61MP0000383_abnormal_hair_follicle1.01556138
62MP0000647_abnormal_sebaceous_gland1.00543748
63MP0003172_abnormal_lysosome_physiology1.00117940
64MP0010678_abnormal_skin_adnexa1.00080125
65MP0005408_hypopigmentation0.99500641
66MP0003221_abnormal_cardiomyocyte_apopto0.99447066
67MP0003436_decreased_susceptibility_to0.96731442
68MP0001851_eye_inflammation0.96414832
69MP0005174_abnormal_tail_pigmentation0.95971764
70MP0002332_abnormal_exercise_endurance0.93363527
71MP0003303_peritoneal_inflammation0.93252222
72MP0001727_abnormal_embryo_implantation0.92514713
73MP0000015_abnormal_ear_pigmentation0.92080982
74MP0000372_irregular_coat_pigmentation0.90755309
75MP0005332_abnormal_amino_acid0.89914799
76MP0001756_abnormal_urination0.86332099
77MP0002736_abnormal_nociception_after0.86101442
78MP0002132_abnormal_respiratory_system0.85057028
79MP0002090_abnormal_vision0.84762023
80MP0002398_abnormal_bone_marrow0.84509866
81MP0001533_abnormal_skeleton_physiology0.83895043
82MP0008469_abnormal_protein_level0.83230097
83MP0002998_abnormal_bone_remodeling0.81597850
84MP0001873_stomach_inflammation0.81493096
85MP0010234_abnormal_vibrissa_follicle0.75827091
86MP0002693_abnormal_pancreas_physiology0.75549081
87MP0003191_abnormal_cellular_cholesterol0.75050383
88MP0002429_abnormal_blood_cell0.74784255
89MP0000609_abnormal_liver_physiology0.73724829
90MP0001545_abnormal_hematopoietic_system0.73107555
91MP0005397_hematopoietic_system_phenotyp0.73107555
92MP0001968_abnormal_touch/_nociception0.71023080
93MP0002971_abnormal_brown_adipose0.70959413
94MP0002722_abnormal_immune_system0.70787628
95MP0003448_altered_tumor_morphology0.70345904
96MP0005266_abnormal_metabolism0.67591070
97MP0000689_abnormal_spleen_morphology0.66889631
98MP0000703_abnormal_thymus_morphology0.66425155
99MP0004484_altered_response_of0.65837763
100MP0001186_pigmentation_phenotype0.62612118

Predicted human phenotypes

RankGene SetZ-score
1Recurrent gram-negative bacterial infections (HP:0005420)9.69002386
2Recurrent bacterial skin infections (HP:0005406)7.49332649
3Recurrent abscess formation (HP:0002722)6.07495958
4Mediastinal lymphadenopathy (HP:0100721)5.46573991
5Elevated erythrocyte sedimentation rate (HP:0003565)4.72331964
6Abnormality of macrophages (HP:0004311)4.50973865
7Recurrent fungal infections (HP:0002841)4.13302458
8Recurrent skin infections (HP:0001581)4.00436968
9Gingivitis (HP:0000230)3.68660241
10Chronic otitis media (HP:0000389)3.68316266
11Cellulitis (HP:0100658)3.67536947
12Large eyes (HP:0001090)3.62858754
13Chronic obstructive pulmonary disease (HP:0006510)3.32798020
14Obstructive lung disease (HP:0006536)3.32798020
15Hypoplasia of the uterus (HP:0000013)3.15088772
16Osteomyelitis (HP:0002754)3.06857003
17Stomatitis (HP:0010280)3.01705125
18Recurrent pneumonia (HP:0006532)2.98523133
19Recurrent viral infections (HP:0004429)2.91394776
20Aplasia/hypoplasia of the uterus (HP:0008684)2.88134672
21Meningitis (HP:0001287)2.86613055
22Urticaria (HP:0001025)2.82862469
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.82520636
24Degeneration of the lateral corticospinal tracts (HP:0002314)2.82520636
25Chronic sinusitis (HP:0011109)2.78747508
26Basal ganglia calcification (HP:0002135)2.72301061
27Retrobulbar optic neuritis (HP:0100654)2.56352493
28Optic neuritis (HP:0100653)2.56352493
29Pancreatic cysts (HP:0001737)2.50615701
30Short chin (HP:0000331)2.48322724
31Flat occiput (HP:0005469)2.44234568
32Enlarged epiphyses (HP:0010580)2.44147174
33Menstrual irregularities (HP:0000858)2.42895016
343-Methylglutaconic aciduria (HP:0003535)2.41421565
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.38031193
36Absent/shortened dynein arms (HP:0200106)2.38031193
37Abnormality of the corticospinal tract (HP:0002492)2.31524894
38Abnormality of lateral ventricle (HP:0030047)2.26862278
39Agitation (HP:0000713)2.24600288
40Myositis (HP:0100614)2.22459638
41Recurrent cutaneous fungal infections (HP:0011370)2.21752767
42Chronic mucocutaneous candidiasis (HP:0002728)2.21752767
43Congenital sensorineural hearing impairment (HP:0008527)2.20098405
44Stomach cancer (HP:0012126)2.18827112
45Orchitis (HP:0100796)2.17715232
46Erythema (HP:0010783)2.17631805
47Microcytic anemia (HP:0001935)2.17151962
48Pheochromocytoma (HP:0002666)2.16311023
49Azoospermia (HP:0000027)2.15832158
50Congenital stationary night blindness (HP:0007642)2.03737847
51Mitral stenosis (HP:0001718)2.03157765
52Eczematoid dermatitis (HP:0000976)10.0853103
53Encephalitis (HP:0002383)1.98592023
54Abnormality of the fingertips (HP:0001211)1.97073226
55Overriding aorta (HP:0002623)1.94748666
56Urinary bladder sphincter dysfunction (HP:0002839)1.92368344
57Vertebral arch anomaly (HP:0008438)1.91666408
58Clubbing of toes (HP:0100760)1.89600069
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89424254
60Hypokalemic alkalosis (HP:0001949)1.85169331
61Infertility (HP:0000789)1.78930765
62Neuroendocrine neoplasm (HP:0100634)1.78339240
63Delayed epiphyseal ossification (HP:0002663)1.76281128
64Papillary thyroid carcinoma (HP:0002895)1.75570678
65Cardiomegaly (HP:0001640)1.75043275
66Recurrent bronchitis (HP:0002837)1.74368428
67Neoplasm of the heart (HP:0100544)1.73922103
68Macroglossia (HP:0000158)1.73099233
69Abnormality of B cell number (HP:0010975)1.72007986
70Abnormal spermatogenesis (HP:0008669)1.71232649
71Abnormality of glycolipid metabolism (HP:0010969)1.70725401
72Abnormality of liposaccharide metabolism (HP:0010968)1.70725401
73Abnormality of glycosphingolipid metabolism (HP:0004343)1.70725401
74Hyperventilation (HP:0002883)1.69990033
75Recurrent lower respiratory tract infections (HP:0002783)1.69234605
76Reduced subcutaneous adipose tissue (HP:0003758)1.69145378
77Keratoconjunctivitis sicca (HP:0001097)1.68874674
78Thin bony cortex (HP:0002753)1.68753149
79Abnormality of the basal ganglia (HP:0002134)1.68579628
80True hermaphroditism (HP:0010459)1.67877036
81Neonatal hypoglycemia (HP:0001998)1.66915752
82Cutaneous photosensitivity (HP:0000992)1.66798013
83Keratoconjunctivitis (HP:0001096)1.65213233
84Abnormality of vitamin B metabolism (HP:0004340)1.64746144
85Abnormality of the fovea (HP:0000493)1.62597910
86Sclerocornea (HP:0000647)1.62544714
87Sepsis (HP:0100806)1.62411726
88Intellectual disability, progressive (HP:0006887)1.61900451
89Abnormal ciliary motility (HP:0012262)1.61783148
90Attenuation of retinal blood vessels (HP:0007843)1.60802510
91Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.60560291
92Fair hair (HP:0002286)1.59730885
93Febrile seizures (HP:0002373)1.59569077
94Aplasia/Hypoplasia of the fovea (HP:0008060)1.58976151
95Hypoplasia of the fovea (HP:0007750)1.58976151
96Widely spaced teeth (HP:0000687)1.57006106
97Downturned corners of mouth (HP:0002714)1.56825714
98Brushfield spots (HP:0001088)1.54195670
99Cystic liver disease (HP:0006706)1.54155673
100Panhypogammaglobulinemia (HP:0003139)1.53462729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK4.44901074
2FRK4.13071573
3CAMKK23.34672092
4DYRK32.73030651
5ACVR1B2.70420905
6TAOK32.53672327
7MAP3K142.52259023
8TXK2.48568457
9MAP3K122.43641471
10CAMK1D2.40882740
11MKNK22.28150705
12TRPM72.11166162
13MAP4K12.09172195
14MAP3K52.07526370
15BMPR21.82527745
16SIK21.78178956
17CAMK1G1.77132811
18WNK41.74134243
19PIK3CG1.61397439
20BRD41.56178985
21JAK21.55088888
22MAP3K21.48235652
23PBK1.47542144
24IRAK11.46751245
25MARK31.37572799
26RIPK41.36622859
27MST41.31203076
28ADRBK21.25919763
29SIK31.23801044
30MAP3K91.22201204
31IKBKB1.18512643
32MKNK11.16857921
33CHUK1.16568872
34STK41.15767419
35MAPKAPK31.05634242
36IKBKE1.04062352
37RPS6KA40.99769676
38JAK10.99253681
39STK38L0.98104282
40CDK120.95808379
41MAP3K10.93493656
42BLK0.93313611
43SYK0.92911138
44MAP3K110.91910985
45TEC0.86464701
46KSR10.85493730
47ITK0.84697035
48SCYL20.82383423
49NLK0.82299198
50TYK20.82235988
51CAMKK10.79942010
52CAMK40.79877741
53SGK20.79846505
54BMX0.78983414
55NTRK30.78749740
56LYN0.78245698
57TTK0.75896561
58WNK10.72413736
59WNK30.71371251
60PIM10.70596374
61CAMK10.69072458
62MAP2K40.68435210
63PKN10.67961160
64RPS6KA50.67778021
65KSR20.67554209
66NEK90.66641130
67KIT0.66274422
68NUAK10.66096869
69TAOK10.65133148
70BTK0.61480228
71MAP2K30.61255174
72FGR0.60874909
73GRK70.60678155
74MELK0.57777292
75IRAK20.57451868
76DYRK1B0.57123427
77AKT30.55980659
78SGK30.52727711
79FER0.52303580
80TGFBR20.50812805
81FGFR30.48049657
82EPHA30.44220162
83EIF2AK30.43764099
84TLK10.42761789
85ADRBK10.40811238
86PRKG10.40503217
87HCK0.39635469
88CDK60.38728584
89TYRO30.38652325
90MATK0.38255658
91OXSR10.37634134
92RPS6KB10.37540327
93TBK10.37372751
94SGK4940.37347258
95SGK2230.37347258
96ZAP700.37012895
97TNIK0.35869190
98JAK30.34504699
99MAPK130.33578315
100STK30.33215220

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.55681290
2Allograft rejection_Homo sapiens_hsa053302.77721099
3Autoimmune thyroid disease_Homo sapiens_hsa053202.52213358
4Asthma_Homo sapiens_hsa053102.49721036
5Leishmaniasis_Homo sapiens_hsa051402.25786349
6Renin-angiotensin system_Homo sapiens_hsa046142.19427464
7Alcoholism_Homo sapiens_hsa050342.15903795
8Propanoate metabolism_Homo sapiens_hsa006402.10752440
9Staphylococcus aureus infection_Homo sapiens_hsa051502.10362528
10Osteoclast differentiation_Homo sapiens_hsa043802.05789351
11Viral carcinogenesis_Homo sapiens_hsa052031.99572576
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.99406085
13Phagosome_Homo sapiens_hsa041451.95024307
14Rheumatoid arthritis_Homo sapiens_hsa053231.89459653
15Graft-versus-host disease_Homo sapiens_hsa053321.83770321
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83704948
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69417068
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66955676
19Antigen processing and presentation_Homo sapiens_hsa046121.65081767
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.60367183
21Primary immunodeficiency_Homo sapiens_hsa053401.58186125
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.54003463
23Selenocompound metabolism_Homo sapiens_hsa004501.53685763
24Tuberculosis_Homo sapiens_hsa051521.50949905
25Nitrogen metabolism_Homo sapiens_hsa009101.49385358
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48549710
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48437572
28RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46633086
29Type I diabetes mellitus_Homo sapiens_hsa049401.40276215
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34649952
31Homologous recombination_Homo sapiens_hsa034401.32950220
32Circadian rhythm_Homo sapiens_hsa047101.32211114
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.28416762
34Regulation of autophagy_Homo sapiens_hsa041401.23819151
35Dorso-ventral axis formation_Homo sapiens_hsa043201.22043978
36Legionellosis_Homo sapiens_hsa051341.21962128
37Pertussis_Homo sapiens_hsa051331.19478963
38TNF signaling pathway_Homo sapiens_hsa046681.16977458
39T cell receptor signaling pathway_Homo sapiens_hsa046601.13078194
40Circadian entrainment_Homo sapiens_hsa047131.12805021
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12649460
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11069920
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.08546631
44Hematopoietic cell lineage_Homo sapiens_hsa046401.08294805
45Basal transcription factors_Homo sapiens_hsa030221.06081783
46Chemokine signaling pathway_Homo sapiens_hsa040621.00565929
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99505839
48B cell receptor signaling pathway_Homo sapiens_hsa046620.97426851
49Malaria_Homo sapiens_hsa051440.92708467
50Fatty acid elongation_Homo sapiens_hsa000620.92224159
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90295888
52Measles_Homo sapiens_hsa051620.87618907
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84111211
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83757253
55Herpes simplex infection_Homo sapiens_hsa051680.82784094
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79521150
57Phototransduction_Homo sapiens_hsa047440.77522160
58FoxO signaling pathway_Homo sapiens_hsa040680.77368155
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75826525
60Sulfur metabolism_Homo sapiens_hsa009200.74936069
61Influenza A_Homo sapiens_hsa051640.66553967
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66024395
63Olfactory transduction_Homo sapiens_hsa047400.63747401
64Toxoplasmosis_Homo sapiens_hsa051450.61116230
65Tryptophan metabolism_Homo sapiens_hsa003800.58740562
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.58283716
67Fanconi anemia pathway_Homo sapiens_hsa034600.58173923
68Salmonella infection_Homo sapiens_hsa051320.58059297
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57418953
70Apoptosis_Homo sapiens_hsa042100.57209566
71PPAR signaling pathway_Homo sapiens_hsa033200.56022729
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54377606
73p53 signaling pathway_Homo sapiens_hsa041150.52741409
74ABC transporters_Homo sapiens_hsa020100.52552542
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51999496
76Lysosome_Homo sapiens_hsa041420.51168479
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.49775528
78Collecting duct acid secretion_Homo sapiens_hsa049660.49628969
79Non-small cell lung cancer_Homo sapiens_hsa052230.45166856
80Epstein-Barr virus infection_Homo sapiens_hsa051690.45094903
81Prolactin signaling pathway_Homo sapiens_hsa049170.43719758
82Viral myocarditis_Homo sapiens_hsa054160.41474528
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.40947912
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38545230
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38324469
86Acute myeloid leukemia_Homo sapiens_hsa052210.37146323
87Salivary secretion_Homo sapiens_hsa049700.36636529
88Shigellosis_Homo sapiens_hsa051310.34494454
89mTOR signaling pathway_Homo sapiens_hsa041500.34329121
90Mismatch repair_Homo sapiens_hsa034300.32406324
91Hepatitis B_Homo sapiens_hsa051610.31737745
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.31082548
93Taste transduction_Homo sapiens_hsa047420.29582567
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26659655
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.26052783
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25797642
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25581356
98Non-homologous end-joining_Homo sapiens_hsa034500.24783325
99Morphine addiction_Homo sapiens_hsa050320.23469839
100Inositol phosphate metabolism_Homo sapiens_hsa005620.23364265

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