ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	detection of light stimulus involved in visual perception (GO:0050908)	4.80730499
2	detection of light stimulus involved in sensory perception (GO:0050962)	4.80730499
3	behavioral response to nicotine (GO:0035095)	4.77045330
4	tachykinin receptor signaling pathway (GO:0007217)	4.76441942
5	piRNA metabolic process (GO:0034587)	4.20335198
6	gonadal mesoderm development (GO:0007506)	3.99572802
7	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.96461769
8	protein import into peroxisome matrix (GO:0016558)	3.75577475
9	cellular ketone body metabolic process (GO:0046950)	3.71590615
10	photoreceptor cell maintenance (GO:0045494)	3.69450023
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63684096
12	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.57878505
13	cilium or flagellum-dependent cell motility (GO:0001539)	3.50118985
14	negative regulation of response to food (GO:0032096)	3.47144989
15	negative regulation of appetite (GO:0032099)	3.47144989
16	mating behavior (GO:0007617)	3.46033197
17	sulfation (GO:0051923)	3.45624523
18	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.40493041
19	membrane depolarization during action potential (GO:0086010)	3.36861090
20	inositol phosphate-mediated signaling (GO:0048016)	3.31259775
21	signal peptide processing (GO:0006465)	3.28874974
22	response to pheromone (GO:0019236)	3.28857431
23	icosanoid secretion (GO:0032309)	3.27143576
24	arachidonic acid secretion (GO:0050482)	3.27143576
25	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.25358065
26	ketone body metabolic process (GO:1902224)	3.24014283
27	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.23422998
28	transmission of nerve impulse (GO:0019226)	3.23150854
29	gamma-aminobutyric acid transport (GO:0015812)	3.17722369
30	mechanosensory behavior (GO:0007638)	3.14697562
31	striated muscle atrophy (GO:0014891)	3.13579560
32	regulation of phospholipase A2 activity (GO:0032429)	3.12996684
33	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.11576714
34	oxidative demethylation (GO:0070989)	3.08716928
35	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.07684763
36	regulation of cilium movement (GO:0003352)	3.06391095
37	auditory behavior (GO:0031223)	3.05489157
38	respiratory chain complex IV assembly (GO:0008535)	2.98184093
39	fusion of sperm to egg plasma membrane (GO:0007342)	2.95095446
40	synaptic transmission, cholinergic (GO:0007271)	2.94164571
41	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.93918067
42	neuronal action potential propagation (GO:0019227)	2.92702716
43	positive regulation of meiosis (GO:0045836)	2.86766041
44	indolalkylamine metabolic process (GO:0006586)	2.86339688
45	protein neddylation (GO:0045116)	2.84596970
46	epithelial cilium movement (GO:0003351)	2.83292327
47	spermatid development (GO:0007286)	2.83055386
48	skeletal muscle adaptation (GO:0043501)	2.82667476
49	male meiosis I (GO:0007141)	2.82208666
50	neuropeptide signaling pathway (GO:0007218)	2.80592728
51	prenylation (GO:0097354)	2.79950878
52	protein prenylation (GO:0018342)	2.79950878
53	multicellular organism reproduction (GO:0032504)	2.79406013
54	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.79336337
55	somite development (GO:0061053)	2.77857232
56	male meiosis (GO:0007140)	2.77120674
57	retinal cone cell development (GO:0046549)	2.76465332
58	rhodopsin mediated signaling pathway (GO:0016056)	2.72755240
59	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.72632766
60	cilium movement (GO:0003341)	2.72305628
61	negative regulation of protein oligomerization (GO:0032460)	2.70022204
62	regulation of posttranscriptional gene silencing (GO:0060147)	2.68481635
63	regulation of gene silencing by miRNA (GO:0060964)	2.68481635
64	regulation of gene silencing by RNA (GO:0060966)	2.68481635
65	regulation of memory T cell differentiation (GO:0043380)	2.67135500
66	negative regulation of heart rate (GO:0010459)	2.65306624
67	sperm motility (GO:0030317)	2.63651045
68	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.62904427
69	serotonin metabolic process (GO:0042428)	2.62851491
70	positive regulation of meiotic cell cycle (GO:0051446)	2.62581693
71	type B pancreatic cell development (GO:0003323)	2.62540740
72	pyrimidine nucleobase catabolic process (GO:0006208)	2.61219508
73	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.60802000
74	potassium ion transmembrane transport (GO:0071805)	2.60295386
75	cellular potassium ion transport (GO:0071804)	2.60295386
76	kynurenine metabolic process (GO:0070189)	2.58519655
77	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.58465830
78	NADH dehydrogenase complex assembly (GO:0010257)	2.58465830
79	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.58465830
80	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.57979885
81	auditory receptor cell stereocilium organization (GO:0060088)	2.57530566
82	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.57177271
83	indole-containing compound metabolic process (GO:0042430)	2.52278769
84	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.51534263
85	indole-containing compound catabolic process (GO:0042436)	2.50688708
86	indolalkylamine catabolic process (GO:0046218)	2.50688708
87	tryptophan catabolic process (GO:0006569)	2.50688708
88	regulation of defense response to virus by host (GO:0050691)	2.50504496
89	regulation of sarcomere organization (GO:0060297)	2.49869260
90	DNA methylation involved in gamete generation (GO:0043046)	2.47806487
91	icosanoid transport (GO:0071715)	2.47575459
92	fatty acid derivative transport (GO:1901571)	2.47575459
93	calcium ion import (GO:0070509)	2.46784265
94	synaptic transmission, glutamatergic (GO:0035249)	2.45699233
95	male sex determination (GO:0030238)	2.45643872
96	neural tube formation (GO:0001841)	2.44960428
97	ectoderm development (GO:0007398)	2.44853264
98	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.43944378
99	protein complex biogenesis (GO:0070271)	2.43706846
100	seminiferous tubule development (GO:0072520)	2.42136440

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.62177222
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.30336061
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.09950292
4	VDR_22108803_ChIP-Seq_LS180_Human	3.50481405
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.18046867
6	GBX2_23144817_ChIP-Seq_PC3_Human	3.06813160
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.95566775
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.76633825
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.46520944
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.46023116
11	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.35088723
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33192213
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.01478059
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.01378698
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.98669105
16	P300_19829295_ChIP-Seq_ESCs_Human	1.88506414
17	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.84072923
18	EWS_26573619_Chip-Seq_HEK293_Human	1.83286691
19	FUS_26573619_Chip-Seq_HEK293_Human	1.80352876
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.74978624
21	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.66432260
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.65269726
23	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.63822810
24	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.59612487
25	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.59612487
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.54970216
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.54241704
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53853395
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.53484502
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52791840
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.50322933
32	SMAD4_21799915_ChIP-Seq_A2780_Human	1.49814911
33	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46919511
34	STAT3_23295773_ChIP-Seq_U87_Human	1.45597160
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.44733583
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43850392
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41925085
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.38542182
39	CBP_20019798_ChIP-Seq_JUKART_Human	1.38542182
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37699593
41	TCF4_23295773_ChIP-Seq_U87_Human	1.37055812
42	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.34204207
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.33480622
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.32666477
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32377745
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32189662
47	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30959912
48	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.30810389
49	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30478130
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30196548
51	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.28284053
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28047899
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.26645996
54	AR_25329375_ChIP-Seq_VCAP_Human	1.25595494
55	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.25471568
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20415370
57	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19337369
58	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19130688
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18888561
60	NANOG_19829295_ChIP-Seq_ESCs_Human	1.18270009
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.18270009
62	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.17920898
63	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17588582
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.15544628
65	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.12408727
66	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.11023361
67	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.10704893
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09719942
69	AR_20517297_ChIP-Seq_VCAP_Human	1.08531696
70	TP53_16413492_ChIP-PET_HCT116_Human	1.07351431
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.07267645
72	RXR_22108803_ChIP-Seq_LS180_Human	1.07223261
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06590209
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06320964
75	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.05407841
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04403515
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04403515
78	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.04029007
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.03548942
80	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.03494988
81	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.01916112
82	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.01139588
83	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.00437063
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99944228
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99906423
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.99262976
87	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.99063645
88	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.98152191
89	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.97959237
90	AR_21572438_ChIP-Seq_LNCaP_Human	0.97410314
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97237281
92	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.96873764
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.96424629
94	HTT_18923047_ChIP-ChIP_STHdh_Human	0.96121201
95	DROSHA_22980978_ChIP-Seq_HELA_Human	0.95827926
96	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.95362914
97	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94019204
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.93202158
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.92553283
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92418738

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.08522290
2	MP0002735_abnormal_chemical_nociception	2.97397223
3	MP0005645_abnormal_hypothalamus_physiol	2.79036209
4	MP0003787_abnormal_imprinting	2.69142284
5	MP0005551_abnormal_eye_electrophysiolog	2.57898757
6	MP0000569_abnormal_digit_pigmentation	2.49806681
7	MP0006276_abnormal_autonomic_nervous	2.48970954
8	MP0002736_abnormal_nociception_after	2.45955818
9	MP0005646_abnormal_pituitary_gland	2.41801773
10	MP0003880_abnormal_central_pattern	2.39411820
11	MP0001968_abnormal_touch/_nociception	2.34597530
12	MP0003879_abnormal_hair_cell	2.22467067
13	MP0002160_abnormal_reproductive_system	2.17903483
14	MP0002163_abnormal_gland_morphology	2.14861656
15	MP0005083_abnormal_biliary_tract	2.10881889
16	MP0001542_abnormal_bone_strength	2.10020233
17	MP0002138_abnormal_hepatobiliary_system	1.99975296
18	MP0003011_delayed_dark_adaptation	1.97001547
19	MP0005410_abnormal_fertilization	1.94091719
20	MP0005379_endocrine/exocrine_gland_phen	1.93125161
21	MP0002822_catalepsy	1.91354096
22	MP0004142_abnormal_muscle_tone	1.91030576
23	MP0002733_abnormal_thermal_nociception	1.84907617
24	MP0002272_abnormal_nervous_system	1.83956770
25	MP0008004_abnormal_stomach_pH	1.77679678
26	MP0009046_muscle_twitch	1.75012752
27	MP0009745_abnormal_behavioral_response	1.66444248
28	MP0005394_taste/olfaction_phenotype	1.65176672
29	MP0005499_abnormal_olfactory_system	1.65176672
30	MP0003638_abnormal_response/metabolism_	1.63513067
31	MP0003045_fibrosis	1.63196949
32	MP0001501_abnormal_sleep_pattern	1.61290415
33	MP0001970_abnormal_pain_threshold	1.59724568
34	MP0002837_dystrophic_cardiac_calcinosis	1.58484980
35	MP0001440_abnormal_grooming_behavior	1.58401546
36	MP0010368_abnormal_lymphatic_system	1.55059398
37	MP0001485_abnormal_pinna_reflex	1.54269622
38	MP0001486_abnormal_startle_reflex	1.53853155
39	MP0003195_calcinosis	1.46501182
40	MP0001529_abnormal_vocalization	1.45083501
41	MP0003646_muscle_fatigue	1.44375804
42	MP0004885_abnormal_endolymph	1.42290795
43	MP0004043_abnormal_pH_regulation	1.40605959
44	MP0003635_abnormal_synaptic_transmissio	1.39470697
45	MP0004147_increased_porphyrin_level	1.37151102
46	MP0008789_abnormal_olfactory_epithelium	1.35944199
47	MP0002638_abnormal_pupillary_reflex	1.29285244
48	MP0005389_reproductive_system_phenotype	1.27728593
49	MP0002064_seizures	1.19491188
50	MP0003698_abnormal_male_reproductive	1.18608352
51	MP0002184_abnormal_innervation	1.18464176
52	MP0008875_abnormal_xenobiotic_pharmacok	1.18107938
53	MP0000372_irregular_coat_pigmentation	1.18008439
54	MP0005084_abnormal_gallbladder_morpholo	1.13131564
55	MP0005195_abnormal_posterior_eye	1.12680116
56	MP0002234_abnormal_pharynx_morphology	1.11552889
57	MP0002067_abnormal_sensory_capabilities	1.10375927
58	MP0008775_abnormal_heart_ventricle	1.10321510
59	MP0002938_white_spotting	1.08502663
60	MP0005253_abnormal_eye_physiology	1.06743984
61	MP0002572_abnormal_emotion/affect_behav	1.06289682
62	MP0002210_abnormal_sex_determination	1.05820587
63	MP0004215_abnormal_myocardial_fiber	1.04894373
64	MP0002752_abnormal_somatic_nervous	1.04393443
65	MP0002102_abnormal_ear_morphology	1.03117975
66	MP0002557_abnormal_social/conspecific_i	0.98728600
67	MP0000778_abnormal_nervous_system	0.98705416
68	MP0001929_abnormal_gametogenesis	0.98245683
69	MP0000653_abnormal_sex_gland	0.98145290
70	MP0005187_abnormal_penis_morphology	0.97860773
71	MP0003959_abnormal_lean_body	0.96681568
72	MP0001145_abnormal_male_reproductive	0.96331003
73	MP0004924_abnormal_behavior	0.95194409
74	MP0005386_behavior/neurological_phenoty	0.95194409
75	MP0000631_abnormal_neuroendocrine_gland	0.95005500
76	MP0003121_genomic_imprinting	0.94624575
77	MP0006292_abnormal_olfactory_placode	0.94203627
78	MP0005423_abnormal_somatic_nervous	0.93858575
79	MP0008872_abnormal_physiological_respon	0.93659775
80	MP0002063_abnormal_learning/memory/cond	0.93591921
81	MP0001963_abnormal_hearing_physiology	0.92745775
82	MP0005360_urolithiasis	0.91356349
83	MP0000026_abnormal_inner_ear	0.90691657
84	MP0005448_abnormal_energy_balance	0.90606285
85	MP0003633_abnormal_nervous_system	0.89335807
86	MP0003119_abnormal_digestive_system	0.89131520
87	MP0000230_abnormal_systemic_arterial	0.88473974
88	MP0005377_hearing/vestibular/ear_phenot	0.88099203
89	MP0003878_abnormal_ear_physiology	0.88099203
90	MP0004742_abnormal_vestibular_system	0.86786620
91	MP0001502_abnormal_circadian_rhythm	0.86243479
92	MP0005174_abnormal_tail_pigmentation	0.85403907
93	MP0002653_abnormal_ependyma_morphology	0.85312290
94	MP0006035_abnormal_mitochondrial_morpho	0.85092189
95	MP0000538_abnormal_urinary_bladder	0.84967311
96	MP0002882_abnormal_neuron_morphology	0.83690946
97	MP0003631_nervous_system_phenotype	0.83268144
98	MP0001879_abnormal_lymphatic_vessel	0.82938934
99	MP0009053_abnormal_anal_canal	0.81564662
100	MP0010386_abnormal_urinary_bladder	0.79707209

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Bony spicule pigmentary retinopathy (HP:0007737)	4.19141536
2	Pancreatic cysts (HP:0001737)	3.83981763
3	Abolished electroretinogram (ERG) (HP:0000550)	3.75270400
4	Congenital stationary night blindness (HP:0007642)	3.67674379
5	Pancreatic fibrosis (HP:0100732)	3.61476555
6	Type II lissencephaly (HP:0007260)	3.60996372
7	Cerebellar dysplasia (HP:0007033)	3.43327413
8	Renal cortical cysts (HP:0000803)	3.41458134
9	True hermaphroditism (HP:0010459)	3.39003201
10	Attenuation of retinal blood vessels (HP:0007843)	3.18742782
11	Hyperventilation (HP:0002883)	3.07930252
12	Hypoplasia of the uterus (HP:0000013)	2.99497831
13	Abnormality of the renal cortex (HP:0011035)	2.89205416
14	Abnormal number of erythroid precursors (HP:0012131)	2.88042687
15	Febrile seizures (HP:0002373)	2.78507011
16	Cystic liver disease (HP:0006706)	2.75183486
17	Congenital sensorineural hearing impairment (HP:0008527)	2.71707833
18	Central scotoma (HP:0000603)	2.70429648
19	Clumsiness (HP:0002312)	2.69249642
20	Abnormality of macular pigmentation (HP:0008002)	2.68408478
21	Decreased circulating renin level (HP:0003351)	2.65675868
22	Nephronophthisis (HP:0000090)	2.63913535
23	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.58167558
24	Medial flaring of the eyebrow (HP:0010747)	2.54049558
25	Abnormality of cells of the erythroid lineage (HP:0012130)	2.51599176
26	Gaze-evoked nystagmus (HP:0000640)	2.48411825
27	Male pseudohermaphroditism (HP:0000037)	2.46002705
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.43716372
29	Elevated erythrocyte sedimentation rate (HP:0003565)	2.41426755
30	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.38776144
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.38776144
32	Abnormality of the renal medulla (HP:0100957)	2.37694181
33	Molar tooth sign on MRI (HP:0002419)	2.37518992
34	Abnormality of midbrain morphology (HP:0002418)	2.37518992
35	Abnormal ciliary motility (HP:0012262)	2.34359577
36	Menorrhagia (HP:0000132)	2.33211152
37	Enlarged kidneys (HP:0000105)	2.30884126
38	Broad-based gait (HP:0002136)	2.24402712
39	Abnormal rod and cone electroretinograms (HP:0008323)	2.23296632
40	Increased mean platelet volume (HP:0011877)	2.22343154
41	Hyperglycinemia (HP:0002154)	2.19709990
42	Ketosis (HP:0001946)	2.18456637
43	3-Methylglutaconic aciduria (HP:0003535)	2.18357262
44	Prolonged bleeding time (HP:0003010)	2.18257068
45	Abnormal spermatogenesis (HP:0008669)	2.18091802
46	Scotoma (HP:0000575)	2.17870767
47	Sclerocornea (HP:0000647)	2.17862888
48	Small hand (HP:0200055)	2.14195324
49	Aplasia/hypoplasia of the uterus (HP:0008684)	2.13427370
50	Focal motor seizures (HP:0011153)	2.13292497
51	Lipid accumulation in hepatocytes (HP:0006561)	2.12440624
52	Increased corneal curvature (HP:0100692)	2.11452623
53	Keratoconus (HP:0000563)	2.11452623
54	Tubulointerstitial nephritis (HP:0001970)	2.10002441
55	Gait imbalance (HP:0002141)	2.08755714
56	Protruding tongue (HP:0010808)	2.07625020
57	Abnormal respiratory motile cilium physiology (HP:0012261)	2.07446396
58	Inability to walk (HP:0002540)	2.06179220
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.03814473
60	Tubular atrophy (HP:0000092)	2.03655448
61	Concave nail (HP:0001598)	2.02177175
62	Progressive cerebellar ataxia (HP:0002073)	2.02058706
63	Osteomalacia (HP:0002749)	1.99252368
64	Intestinal atresia (HP:0011100)	1.99153893
65	Absent speech (HP:0001344)	1.97943076
66	Decreased central vision (HP:0007663)	1.97152447
67	Abnormal platelet volume (HP:0011876)	1.96333978
68	Abnormality of binocular vision (HP:0011514)	1.95095733
69	Diplopia (HP:0000651)	1.95095733
70	Retinitis pigmentosa (HP:0000510)	1.94824312
71	Congenital primary aphakia (HP:0007707)	1.94595878
72	Optic nerve hypoplasia (HP:0000609)	1.89844120
73	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.89671868
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.89495821
75	Abnormality of alanine metabolism (HP:0010916)	1.89231537
76	Hyperalaninemia (HP:0003348)	1.89231537
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.89231537
78	Lissencephaly (HP:0001339)	1.88904553
79	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.88068366
80	Nephrogenic diabetes insipidus (HP:0009806)	1.87680885
81	Focal seizures (HP:0007359)	1.86908268
82	Generalized aminoaciduria (HP:0002909)	1.83621235
83	Abnormality of fatty-acid metabolism (HP:0004359)	1.83444283
84	Epileptic encephalopathy (HP:0200134)	1.82467514
85	Chorioretinal atrophy (HP:0000533)	1.82407073
86	Fair hair (HP:0002286)	1.82128681
87	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.80826793
88	Stomatitis (HP:0010280)	1.79001868
89	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.78975397
90	Congenital hepatic fibrosis (HP:0002612)	1.77810978
91	Abnormality of the fovea (HP:0000493)	1.77679102
92	Gonadal dysgenesis (HP:0000133)	1.75425485
93	Methylmalonic acidemia (HP:0002912)	1.74766515
94	Brushfield spots (HP:0001088)	1.74182029
95	Pendular nystagmus (HP:0012043)	1.74104423
96	Anencephaly (HP:0002323)	1.73857412
97	Anterior segment dysgenesis (HP:0007700)	1.72497906
98	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.71371261
99	Status epilepticus (HP:0002133)	1.68399619
100	Azoospermia (HP:0000027)	1.67868655

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.00895066
2	ADRBK2	2.99005089
3	NUAK1	2.73802087
4	BMPR1B	2.55954156
5	TAOK3	2.13123336
6	INSRR	2.12553869
7	ACVR1B	2.11570635
8	EPHA4	2.09168436
9	VRK2	1.96475033
10	MKNK2	1.96351611
11	STK16	1.94157120
12	WNK4	1.92962915
13	CASK	1.92347601
14	STK39	1.84916152
15	MAPKAPK3	1.74944446
16	WNK3	1.73675734
17	BCKDK	1.73398974
18	VRK1	1.71158217
19	MATK	1.67362395
20	ZAK	1.64674120
21	MAPK13	1.60033209
22	TEC	1.59023405
23	PRKCG	1.58980524
24	DYRK2	1.51554267
25	MAP4K2	1.45127577
26	DAPK2	1.42184857
27	ADRBK1	1.41354643
28	STK3	1.31079284
29	TIE1	1.30601388
30	TLK1	1.29513671
31	BMPR2	1.27420183
32	OXSR1	1.24982038
33	NTRK3	1.24780812
34	GRK1	1.23171260
35	EPHB2	1.17577969
36	PKN1	1.13785055
37	IRAK1	1.11682644
38	MAP3K4	1.04716658
39	DAPK1	1.03967356
40	PHKG2	0.98546185
41	PHKG1	0.98546185
42	IKBKB	0.98082900
43	STK24	0.92667386
44	MAP3K9	0.89910572
45	PLK4	0.87708080
46	MARK1	0.87228599
47	MKNK1	0.87205344
48	KIT	0.85850825
49	PAK6	0.84659485
50	TGFBR1	0.83693512
51	PAK3	0.81897219
52	LATS1	0.81386991
53	GRK7	0.81285778
54	TNIK	0.78245093
55	PIK3CG	0.77590608
56	CAMKK2	0.77385886
57	MARK3	0.71913123
58	SIK2	0.70884792
59	PIK3CA	0.68977540
60	KSR1	0.67433890
61	RIPK4	0.67319798
62	MINK1	0.66986966
63	PRKG1	0.65546645
64	PRKCE	0.64936659
65	PRKCQ	0.63848954
66	PRKACA	0.63152197
67	TYRO3	0.62228886
68	ERBB2	0.61190587
69	PTK2B	0.58716360
70	CDK19	0.57988718
71	CAMK2A	0.57515692
72	PRKACG	0.57436410
73	MUSK	0.56077160
74	ITK	0.56015270
75	GRK5	0.53559428
76	AKT3	0.49755946
77	CAMK1	0.48875303
78	PINK1	0.48521594
79	PRKCB	0.46923380
80	STK11	0.44508545
81	TXK	0.43878021
82	BTK	0.42299838
83	TNK2	0.40659328
84	PRKD3	0.39398783
85	TAOK1	0.38379181
86	RPS6KA6	0.37243376
87	MAP2K7	0.36943415
88	IGF1R	0.36115181
89	RPS6KA3	0.35691906
90	PASK	0.35655072
91	PRKCD	0.35180330
92	MAP3K5	0.34348129
93	DYRK3	0.33278145
94	RPS6KA2	0.32110605
95	CAMK2B	0.31387897
96	TAF1	0.31283262
97	BRAF	0.31121499
98	BMX	0.31010075
99	CSNK1E	0.30875733
100	PRKCA	0.29716848

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	3.40839395
2	Nicotine addiction_Homo sapiens_hsa05033	2.88634993
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.75550315
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.30312091
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.30255181
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.27230835
7	Circadian entrainment_Homo sapiens_hsa04713	2.22807179
8	Butanoate metabolism_Homo sapiens_hsa00650	2.20439966
9	Linoleic acid metabolism_Homo sapiens_hsa00591	2.07703018
10	Olfactory transduction_Homo sapiens_hsa04740	2.03726203
11	Morphine addiction_Homo sapiens_hsa05032	1.93995595
12	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.85366256
13	Glycerolipid metabolism_Homo sapiens_hsa00561	1.75870565
14	GABAergic synapse_Homo sapiens_hsa04727	1.74028440
15	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.73537751
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71388862
17	Glutamatergic synapse_Homo sapiens_hsa04724	1.71268370
18	ABC transporters_Homo sapiens_hsa02010	1.68582272
19	Taste transduction_Homo sapiens_hsa04742	1.64218577
20	Serotonergic synapse_Homo sapiens_hsa04726	1.61461198
21	Sulfur relay system_Homo sapiens_hsa04122	1.61231604
22	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.61214504
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.50037345
24	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.46842326
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.40973146
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.35518330
27	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.33133487
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31059846
29	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.30373129
30	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.29825835
31	Homologous recombination_Homo sapiens_hsa03440	1.26346503
32	Insulin secretion_Homo sapiens_hsa04911	1.24187159
33	Retinol metabolism_Homo sapiens_hsa00830	1.24060651
34	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.23784378
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.20593383
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.19082647
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.18091719
38	Selenocompound metabolism_Homo sapiens_hsa00450	1.16026561
39	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.15210698
40	Long-term depression_Homo sapiens_hsa04730	1.13759250
41	RNA polymerase_Homo sapiens_hsa03020	1.10168419
42	Propanoate metabolism_Homo sapiens_hsa00640	1.06124321
43	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.04647749
44	Salivary secretion_Homo sapiens_hsa04970	1.03324339
45	Parkinsons disease_Homo sapiens_hsa05012	1.00635397
46	Calcium signaling pathway_Homo sapiens_hsa04020	0.99442290
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98863533
48	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95674920
49	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.94665613
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.94043490
51	Sulfur metabolism_Homo sapiens_hsa00920	0.92392291
52	Alcoholism_Homo sapiens_hsa05034	0.87877013
53	Ether lipid metabolism_Homo sapiens_hsa00565	0.85038632
54	Huntingtons disease_Homo sapiens_hsa05016	0.84635068
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83555531
56	Peroxisome_Homo sapiens_hsa04146	0.83441830
57	Fatty acid degradation_Homo sapiens_hsa00071	0.81472616
58	Protein export_Homo sapiens_hsa03060	0.81430929
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.79551905
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77969753
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77684748
62	Ribosome_Homo sapiens_hsa03010	0.77680184
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.76834275
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.76552575
65	Pancreatic secretion_Homo sapiens_hsa04972	0.75822893
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.75040087
67	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72667482
68	Gastric acid secretion_Homo sapiens_hsa04971	0.72393425
69	Cholinergic synapse_Homo sapiens_hsa04725	0.70658970
70	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.70246400
71	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67405592
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.66543380
73	Histidine metabolism_Homo sapiens_hsa00340	0.65077985
74	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.64884503
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.62101473
76	Alzheimers disease_Homo sapiens_hsa05010	0.58416263
77	Purine metabolism_Homo sapiens_hsa00230	0.56802441
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55947894
79	cAMP signaling pathway_Homo sapiens_hsa04024	0.55902600
80	Amphetamine addiction_Homo sapiens_hsa05031	0.54748857
81	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.53317722
82	Caffeine metabolism_Homo sapiens_hsa00232	0.52953077
83	Fatty acid metabolism_Homo sapiens_hsa01212	0.50978263
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49479468
85	Bile secretion_Homo sapiens_hsa04976	0.49343299
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48672871
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48347742
88	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.48253272
89	Mineral absorption_Homo sapiens_hsa04978	0.47641961
90	Ras signaling pathway_Homo sapiens_hsa04014	0.47485695
91	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.45465171
92	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.44319051
93	PPAR signaling pathway_Homo sapiens_hsa03320	0.44235553
94	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.42653944
95	Platelet activation_Homo sapiens_hsa04611	0.42445410
96	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.40409411
97	Metabolic pathways_Homo sapiens_hsa01100	0.39754045
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38150971
99	Melanoma_Homo sapiens_hsa05218	0.37720672
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.37119393

PABPC1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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