PABPC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.43924850
2DNA unwinding involved in DNA replication (GO:0006268)4.24480654
3folic acid-containing compound biosynthetic process (GO:0009396)4.23050703
4nuclear pore organization (GO:0006999)4.15022199
5formation of translation preinitiation complex (GO:0001731)4.03938295
6mitotic nuclear envelope disassembly (GO:0007077)4.02420951
7IMP biosynthetic process (GO:0006188)3.97249933
8nuclear pore complex assembly (GO:0051292)3.93507352
9mitotic metaphase plate congression (GO:0007080)3.89860903
10protein localization to chromosome, centromeric region (GO:0071459)3.78707051
11nuclear envelope disassembly (GO:0051081)3.76113331
12membrane disassembly (GO:0030397)3.76113331
13regulation of spindle organization (GO:0090224)3.63837965
14IMP metabolic process (GO:0046040)3.62050840
15pre-miRNA processing (GO:0031054)3.60415538
16nucleobase biosynthetic process (GO:0046112)3.59289531
17regulation of nucleobase-containing compound transport (GO:0032239)3.59072005
18heterochromatin organization (GO:0070828)3.58440934
19regulation of translational fidelity (GO:0006450)3.55490630
20DNA replication initiation (GO:0006270)3.55144907
21regulation of translational termination (GO:0006449)3.55122986
22mitotic sister chromatid segregation (GO:0000070)3.52823439
23ribosomal small subunit biogenesis (GO:0042274)3.51126318
24ribosome assembly (GO:0042255)3.50364468
25positive regulation of chromosome segregation (GO:0051984)3.46348706
26regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.45403666
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.42551741
28DNA replication checkpoint (GO:0000076)3.41897155
29mitotic chromosome condensation (GO:0007076)3.39331669
30maturation of SSU-rRNA (GO:0030490)3.38257616
31sister chromatid segregation (GO:0000819)3.31664927
32regulation of mitotic spindle organization (GO:0060236)3.30762627
33regulation of gene silencing by RNA (GO:0060966)3.29700871
34regulation of posttranscriptional gene silencing (GO:0060147)3.29700871
35regulation of gene silencing by miRNA (GO:0060964)3.29700871
36metaphase plate congression (GO:0051310)3.22228689
37protein complex localization (GO:0031503)3.22187415
38nuclear envelope organization (GO:0006998)3.19233683
39cellular protein complex localization (GO:0034629)3.19020298
40DNA replication-dependent nucleosome assembly (GO:0006335)3.18966399
41DNA replication-dependent nucleosome organization (GO:0034723)3.18966399
42DNA strand elongation involved in DNA replication (GO:0006271)3.16570845
43translational initiation (GO:0006413)3.15719643
44COPI coating of Golgi vesicle (GO:0048205)3.15151566
45Golgi transport vesicle coating (GO:0048200)3.15151566
46purine nucleobase biosynthetic process (GO:0009113)3.15037484
47cell-substrate adherens junction assembly (GO:0007045)3.11366564
48focal adhesion assembly (GO:0048041)3.11366564
493-UTR-mediated mRNA stabilization (GO:0070935)3.09386277
50ribosome biogenesis (GO:0042254)3.07209513
51regulation of NFAT protein import into nucleus (GO:0051532)3.07209205
52DNA duplex unwinding (GO:0032508)3.07004403
53paraxial mesoderm development (GO:0048339)3.06421049
54DNA geometric change (GO:0032392)3.04483634
55translational termination (GO:0006415)3.04292612
56regulation of histone H3-K27 methylation (GO:0061085)3.03093714
57viral transcription (GO:0019083)3.03028366
58sarcomere organization (GO:0045214)2.99787108
59negative regulation of histone methylation (GO:0031061)2.99586045
60histone H2A monoubiquitination (GO:0035518)2.98428266
61DNA strand elongation (GO:0022616)2.98133654
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97998436
63chromatin assembly (GO:0031497)2.97557576
64RNA stabilization (GO:0043489)2.95243249
65mRNA stabilization (GO:0048255)2.95243249
66regulation of RNA export from nucleus (GO:0046831)2.94768778
67adherens junction assembly (GO:0034333)2.94669194
68pinocytosis (GO:0006907)2.94310346
69protein localization to chromosome (GO:0034502)2.92805096
70chromosome condensation (GO:0030261)2.91207548
71pore complex assembly (GO:0046931)2.90265116
72translational elongation (GO:0006414)2.88241218
73regulation of early endosome to late endosome transport (GO:2000641)2.87379244
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.86946308
75folic acid metabolic process (GO:0046655)2.86402831
76regulation of glucose import in response to insulin stimulus (GO:2001273)2.82849391
77negative regulation of translational initiation (GO:0045947)2.81451539
78regulation of histone H3-K9 methylation (GO:0051570)2.78638371
79regulation of mRNA stability (GO:0043488)2.77594204
80ribonucleoprotein complex biogenesis (GO:0022613)2.76408148
81positive regulation of mitotic sister chromatid separation (GO:1901970)2.75731705
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75731705
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75731705
84protein export from nucleus (GO:0006611)2.75472360
85regulation of hippo signaling (GO:0035330)2.75262216
86cardiac myofibril assembly (GO:0055003)2.74609461
87peptidyl-arginine omega-N-methylation (GO:0035247)2.74342871
88DNA synthesis involved in DNA repair (GO:0000731)2.73161444
89regulation of sister chromatid cohesion (GO:0007063)2.73008814
90DNA topological change (GO:0006265)2.71974571
91establishment of chromosome localization (GO:0051303)2.69962807
92negative regulation of cell size (GO:0045792)2.69901621
93ribosomal large subunit biogenesis (GO:0042273)2.69105811
94chromatin assembly or disassembly (GO:0006333)2.68601996
95regulation of chromosome segregation (GO:0051983)2.67848977
96trophectodermal cell differentiation (GO:0001829)2.67682078
97negative regulation of RNA splicing (GO:0033119)2.67653702
98proline biosynthetic process (GO:0006561)2.67360895
99cellular hyperosmotic response (GO:0071474)2.67014681
100embryonic process involved in female pregnancy (GO:0060136)2.64996530
101positive regulation of SMAD protein import into nucleus (GO:0060391)2.64256302
102skeletal muscle contraction (GO:0003009)2.63158773
103mitotic sister chromatid cohesion (GO:0007064)2.62907155
104peptidyl-lysine dimethylation (GO:0018027)2.62181594
105regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62167411
106negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.61913778
107ribosomal small subunit assembly (GO:0000028)2.61840104
108histone H3-K36 demethylation (GO:0070544)2.61672935
109negative regulation of DNA repair (GO:0045738)2.61502602
110regulation of RNA stability (GO:0043487)2.61355049
111cardiac muscle cell development (GO:0055013)2.60610074
112negative regulation of mRNA metabolic process (GO:1903312)2.60020198
113cell-substrate junction assembly (GO:0007044)2.58825354
114negative regulation of mRNA processing (GO:0050686)2.58474174
115maternal placenta development (GO:0001893)2.57103914
116dosage compensation (GO:0007549)2.56596137
117histone-serine phosphorylation (GO:0035404)2.55765360
118mitotic G1 DNA damage checkpoint (GO:0031571)2.54632306
119negative regulation of erythrocyte differentiation (GO:0045647)2.54424706
120glucocorticoid receptor signaling pathway (GO:0042921)2.53960071
121spindle checkpoint (GO:0031577)2.53068007
122negative regulation of chromosome segregation (GO:0051985)2.51884302
123negative regulation of necroptotic process (GO:0060546)2.51497120
124positive regulation of myotube differentiation (GO:0010831)2.48852612
125nucleobase-containing small molecule interconversion (GO:0015949)2.48561476
126positive regulation of DNA-dependent DNA replication (GO:2000105)2.48444315
127telomere maintenance via semi-conservative replication (GO:0032201)2.48269842
128attachment of spindle microtubules to kinetochore (GO:0008608)2.48034242
129spliceosomal tri-snRNP complex assembly (GO:0000244)2.47487827
130rRNA processing (GO:0006364)2.47236366
131mitotic spindle checkpoint (GO:0071174)2.46147609
132DNA conformation change (GO:0071103)2.46021112
133ventricular cardiac muscle cell development (GO:0055015)2.45873131
134RNA splicing, via transesterification reactions (GO:0000375)2.45600661
135actin-myosin filament sliding (GO:0033275)2.44952551
136muscle filament sliding (GO:0030049)2.44952551
137actin-mediated cell contraction (GO:0070252)2.43590991
138apoptotic process involved in morphogenesis (GO:0060561)2.40853382
139DNA packaging (GO:0006323)2.39636317
140mannose metabolic process (GO:0006013)2.39534098
141regulation of chromatin binding (GO:0035561)2.39373095
142mRNA transport (GO:0051028)2.37531223
143mitochondrial fusion (GO:0008053)2.33256794
144positive regulation of nuclease activity (GO:0032075)2.32583417
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.32039965
146activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.28679098
147nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.28551120
148negative regulation of skeletal muscle tissue development (GO:0048642)2.27142244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.51509239
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.60954052
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82386912
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.77182552
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07134810
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86366465
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85367719
8MYC_22102868_ChIP-Seq_BL_Human2.58728896
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.43509225
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42967591
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23724287
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.08681903
13* AR_21909140_ChIP-Seq_LNCAP_Human2.06399032
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05404790
15XRN2_22483619_ChIP-Seq_HELA_Human2.01113545
16ZNF263_19887448_ChIP-Seq_K562_Human1.99183002
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.95341217
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89328120
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.87506290
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.85516280
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.78678021
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77816950
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.77291446
24MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72934859
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72611578
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70082994
27CIITA_25753668_ChIP-Seq_RAJI_Human1.66239902
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61731359
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60490930
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60386840
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54964831
32KDM5A_27292631_Chip-Seq_BREAST_Human1.54254931
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53593465
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52336380
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51239234
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50776077
37* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49049009
38VDR_21846776_ChIP-Seq_THP-1_Human1.48956772
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48245924
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47934961
41GABP_19822575_ChIP-Seq_HepG2_Human1.47164353
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46693866
43VDR_23849224_ChIP-Seq_CD4+_Human1.46031413
44DCP1A_22483619_ChIP-Seq_HELA_Human1.45473033
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.43779192
46* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43758380
47* LXR_22292898_ChIP-Seq_THP-1_Human1.43181249
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41270687
49TTF2_22483619_ChIP-Seq_HELA_Human1.39866555
50FOXP3_21729870_ChIP-Seq_TREG_Human1.37052084
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.36893841
52* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36843351
53* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35189873
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34934970
55* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34639687
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34219652
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33166390
58ATF3_27146783_Chip-Seq_COLON_Human1.32481452
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30931991
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29581614
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29578570
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26961229
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26605158
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.24386220
65ELK3_25401928_ChIP-Seq_HUVEC_Human1.22054258
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.20994775
67TFEB_21752829_ChIP-Seq_HELA_Human1.19347241
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18576912
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15993718
70* VDR_24763502_ChIP-Seq_THP-1_Human1.13951169
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10256982
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10094552
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09710351
74* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09318662
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08841185
76TCF7_22412390_ChIP-Seq_EML_Mouse1.08639956
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08101500
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.07671976
79TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07087509
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06842245
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05757741
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05664116
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.05470022
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05351926
85* MAF_26560356_Chip-Seq_TH2_Human1.05311204
86* CHD1_26751641_Chip-Seq_LNCaP_Human1.04396497
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04269640
88* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04021249
89KDM2B_26808549_Chip-Seq_DND41_Human1.03647341
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03455543
91NCOR1_26117541_ChIP-Seq_K562_Human1.02551202
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00869653
93* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00840256
94* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00281922
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00239888
96ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99630213
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.99589004
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99132563
99NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98298612
100* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97915028
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96615769
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96105097
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96049605
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95947840
105HIF1A_21447827_ChIP-Seq_MCF-7_Human0.95745906
106* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94779275
107CLOCK_20551151_ChIP-Seq_293T_Human0.94616811
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94429098
109CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94305205
110* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94132674
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93735054
112* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93382092
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93174465
114* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92203389
115RUNX1_22412390_ChIP-Seq_EML_Mouse0.92068883
116* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91333563
117POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91168423
118UTX_26944678_Chip-Seq_JUKART_Human0.90348986
119NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89957410
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89207881
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88533884
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88533884
123KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88533884
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86822368
125* MAF_26560356_Chip-Seq_TH1_Human0.86388068
126RACK7_27058665_Chip-Seq_MCF-7_Human0.85322474
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85013398
128ELK1_19687146_ChIP-ChIP_HELA_Human0.84800554
129E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84523059

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.65542649
2MP0005451_abnormal_body_composition3.56209529
3MP0003111_abnormal_nucleus_morphology3.48190507
4MP0004957_abnormal_blastocyst_morpholog3.19163320
5MP0003077_abnormal_cell_cycle2.82386771
6MP0010094_abnormal_chromosome_stability2.79859223
7MP0003705_abnormal_hypodermis_morpholog2.75687634
8MP0004084_abnormal_cardiac_muscle2.57604018
9MP0010352_gastrointestinal_tract_polyps2.51120166
10MP0003646_muscle_fatigue2.29100636
11MP0001730_embryonic_growth_arrest2.26126536
12MP0008057_abnormal_DNA_replication2.04847399
13MP0003123_paternal_imprinting2.01837849
14MP0003567_abnormal_fetal_cardiomyocyte1.99788411
15MP0000750_abnormal_muscle_regeneration1.97273768
16MP0001672_abnormal_embryogenesis/_devel1.95999240
17MP0005380_embryogenesis_phenotype1.95999240
18MP0003984_embryonic_growth_retardation1.90860196
19MP0000350_abnormal_cell_proliferation1.90128851
20MP0002088_abnormal_embryonic_growth/wei1.88113701
21MP0005076_abnormal_cell_differentiation1.83869979
22MP0010234_abnormal_vibrissa_follicle1.80257063
23MP0002837_dystrophic_cardiac_calcinosis1.79060247
24MP0010307_abnormal_tumor_latency1.75342605
25MP0001697_abnormal_embryo_size1.75096414
26MP0005330_cardiomyopathy1.67865190
27MP0004197_abnormal_fetal_growth/weight/1.66507189
28MP0004087_abnormal_muscle_fiber1.65933530
29MP0010630_abnormal_cardiac_muscle1.63051635
30MP0002086_abnormal_extraembryonic_tissu1.61909565
31MP0000751_myopathy1.61629621
32MP0003221_abnormal_cardiomyocyte_apopto1.61550361
33MP0008932_abnormal_embryonic_tissue1.60687039
34MP0002084_abnormal_developmental_patter1.58833419
35MP0002396_abnormal_hematopoietic_system1.58015353
36MP0008007_abnormal_cellular_replicative1.57528864
37MP0002080_prenatal_lethality1.57165377
38MP0004185_abnormal_adipocyte_glucose1.56185517
39MP0002085_abnormal_embryonic_tissue1.55144551
40MP0003566_abnormal_cell_adhesion1.50010510
41MP0002269_muscular_atrophy1.49928375
42MP0000749_muscle_degeneration1.48187408
43MP0001661_extended_life_span1.46991058
44MP0000733_abnormal_muscle_development1.46428002
45MP0004215_abnormal_myocardial_fiber1.43161242
46MP0005058_abnormal_lysosome_morphology1.40766877
47MP0008058_abnormal_DNA_repair1.40125735
48MP0004233_abnormal_muscle_weight1.39857438
49MP0004036_abnormal_muscle_relaxation1.39082746
50MP0010030_abnormal_orbit_morphology1.34454753
51MP0003656_abnormal_erythrocyte_physiolo1.33175128
52MP0008775_abnormal_heart_ventricle1.31802229
53MP0002796_impaired_skin_barrier1.29447753
54MP0003828_pulmonary_edema1.29206908
55MP0003453_abnormal_keratinocyte_physiol1.28807310
56MP0000747_muscle_weakness1.27795029
57MP0002106_abnormal_muscle_physiology1.27710312
58MP0004808_abnormal_hematopoietic_stem1.27280552
59MP0009672_abnormal_birth_weight1.26420972
60MP0002009_preneoplasia1.23812650
61MP0002060_abnormal_skin_morphology1.17679678
62MP0005666_abnormal_adipose_tissue1.16863575
63MP0003091_abnormal_cell_migration1.16601084
64MP0001544_abnormal_cardiovascular_syste1.14628515
65MP0005385_cardiovascular_system_phenoty1.14628515
66MP0002877_abnormal_melanocyte_morpholog1.14609382
67MP0009278_abnormal_bone_marrow1.13341739
68MP0000759_abnormal_skeletal_muscle1.12919007
69MP0000490_abnormal_crypts_of1.12719163
70MP0004272_abnormal_basement_membrane1.12164991
71MP0000266_abnormal_heart_morphology1.11687707
72MP0000003_abnormal_adipose_tissue1.11206285
73MP0006138_congestive_heart_failure1.10233452
74MP0000313_abnormal_cell_death1.09491644
75MP0005501_abnormal_skin_physiology1.07797418
76MP0003119_abnormal_digestive_system1.07550675
77MP0000537_abnormal_urethra_morphology1.07062695
78MP0000678_abnormal_parathyroid_gland1.06763171
79MP0005397_hematopoietic_system_phenotyp1.05150740
80MP0001545_abnormal_hematopoietic_system1.05150740
81MP0001849_ear_inflammation1.04290101
82MP0009840_abnormal_foam_cell1.03603525
83MP0003950_abnormal_plasma_membrane1.02284609
84MP0009053_abnormal_anal_canal1.00560402
85MP0000428_abnormal_craniofacial_morphol0.98089001
86MP0002019_abnormal_tumor_incidence0.97554436
87MP0002108_abnormal_muscle_morphology0.96849154
88MP0005369_muscle_phenotype0.96748424
89MP0002089_abnormal_postnatal_growth/wei0.94468242
90MP0002925_abnormal_cardiovascular_devel0.94093236
91MP0005257_abnormal_intraocular_pressure0.93142622
92MP0009703_decreased_birth_body0.92666082
93MP0001348_abnormal_lacrimal_gland0.92272279
94MP0002972_abnormal_cardiac_muscle0.91407210
95MP0003763_abnormal_thymus_physiology0.91372352
96MP0005623_abnormal_meninges_morphology0.91296140
97MP0008260_abnormal_autophagy0.90795835
98MP0005023_abnormal_wound_healing0.90380431
99MP0002127_abnormal_cardiovascular_syste0.89592229
100MP0003806_abnormal_nucleotide_metabolis0.86575437
101MP0005409_darkened_coat_color0.85718028
102MP0003786_premature_aging0.83977251
103MP0001915_intracranial_hemorrhage0.83700811
104MP0005375_adipose_tissue_phenotype0.82583627
105MP0004145_abnormal_muscle_electrophysio0.82123260
106MP0005620_abnormal_muscle_contractility0.80872731
107MP0009333_abnormal_splenocyte_physiolog0.80780129
108MP0008770_decreased_survivor_rate0.80144971
109MP0008438_abnormal_cutaneous_collagen0.79737398
110MP0000858_altered_metastatic_potential0.77150804
111MP0003718_maternal_effect0.75784600
112MP0002111_abnormal_tail_morphology0.74409878
113MP0000358_abnormal_cell_content/0.74096164
114MP0005384_cellular_phenotype0.74092044
115MP0003121_genomic_imprinting0.73115955
116MP0006036_abnormal_mitochondrial_physio0.72725826
117MP0000762_abnormal_tongue_morphology0.72382843
118MP0005621_abnormal_cell_physiology0.71968094
119MP0004858_abnormal_nervous_system0.71533072
120MP0003941_abnormal_skin_development0.71525977
121MP0001293_anophthalmia0.71467333
122MP0003300_gastrointestinal_ulcer0.71176478
123MP0003137_abnormal_impulse_conducting0.70968930
124MP0006054_spinal_hemorrhage0.70587724
125MP0004264_abnormal_extraembryonic_tissu0.69680987
126MP0009931_abnormal_skin_appearance0.69274655
127MP0003935_abnormal_craniofacial_develop0.68952902
128MP0003115_abnormal_respiratory_system0.68031496
129MP0003937_abnormal_limbs/digits/tail_de0.67854768

Predicted human phenotypes

RankGene SetZ-score
1Centrally nucleated skeletal muscle fibers (HP:0003687)3.86020981
2Muscle fiber splitting (HP:0003555)3.56628142
3Increased connective tissue (HP:0009025)3.37823704
4Exercise-induced muscle cramps (HP:0003710)3.31221251
5Difficulty climbing stairs (HP:0003551)3.28153923
6Ventricular tachycardia (HP:0004756)3.26752961
7Abnormality of skeletal muscle fiber size (HP:0012084)3.16153714
8Sudden death (HP:0001699)3.14938883
9Multiple enchondromatosis (HP:0005701)3.10656407
10Ependymoma (HP:0002888)3.00214474
11Round ear (HP:0100830)2.90434470
12Distal lower limb amyotrophy (HP:0008944)2.89988304
13Increased variability in muscle fiber diameter (HP:0003557)2.86798125
14Abnormality of the left ventricular outflow tract (HP:0011103)2.84136261
15Subaortic stenosis (HP:0001682)2.84136261
16Birth length less than 3rd percentile (HP:0003561)2.83319758
17Distal arthrogryposis (HP:0005684)2.80193172
18Distal lower limb muscle weakness (HP:0009053)2.78818134
19Spinal rigidity (HP:0003306)2.75497333
20Hyperacusis (HP:0010780)2.75173637
21Selective tooth agenesis (HP:0001592)2.65670081
22Rhabdomyolysis (HP:0003201)2.64024530
23Reticulocytosis (HP:0001923)2.58104810
24Abnormality of cells of the erythroid lineage (HP:0012130)2.53298932
25Protrusio acetabuli (HP:0003179)2.49434909
26Breast hypoplasia (HP:0003187)2.44892216
27Abnormal number of erythroid precursors (HP:0012131)2.37392868
28Abnormality of reticulocytes (HP:0004312)2.37104339
29Ankle contracture (HP:0006466)2.35158403
30Abnormality of the Achilles tendon (HP:0005109)2.35071063
31Trismus (HP:0000211)2.34956941
32Right ventricular cardiomyopathy (HP:0011663)2.33701660
33Type 1 muscle fiber predominance (HP:0003803)2.32547048
34Lipoatrophy (HP:0100578)2.31814634
35Atrioventricular block (HP:0001678)2.31318250
36Neck muscle weakness (HP:0000467)2.30002588
37Hyporeflexia of lower limbs (HP:0002600)2.27913471
38Pelvic girdle muscle weakness (HP:0003749)2.27817268
39Myoglobinuria (HP:0002913)2.27645543
40Dysmetric saccades (HP:0000641)2.25519231
41Progressive external ophthalmoplegia (HP:0000590)2.22729810
42Ragged-red muscle fibers (HP:0003200)2.20939444
43Difficulty running (HP:0009046)2.19968628
44Bundle branch block (HP:0011710)2.18424362
45Abnormality of the calcaneus (HP:0008364)2.18185980
46Patellar aplasia (HP:0006443)2.17777836
47Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.15563105
48Progressive muscle weakness (HP:0003323)2.15252035
49Calf muscle hypertrophy (HP:0008981)2.14031265
50Muscle stiffness (HP:0003552)2.13852389
51Premature rupture of membranes (HP:0001788)2.13040702
52Aplasia/Hypoplasia of the patella (HP:0006498)2.11865566
53Muscle fiber inclusion bodies (HP:0100299)2.11828936
54Disproportionate tall stature (HP:0001519)2.09146297
55Rectal prolapse (HP:0002035)2.09020213
56Generalized amyotrophy (HP:0003700)2.08524299
57Deviation of the thumb (HP:0009603)2.08469836
58Vertebral compression fractures (HP:0002953)2.06188588
59Adenoma sebaceum (HP:0009720)2.04549369
60Angiofibromas (HP:0010615)2.04549369
61Asymmetry of the thorax (HP:0001555)2.04362537
62Proximal placement of thumb (HP:0009623)2.04026647
63Ankyloglossia (HP:0010296)2.03013321
64Ureteral duplication (HP:0000073)2.02240235
65Ulnar bowing (HP:0003031)2.00054044
66Reticulocytopenia (HP:0001896)1.99770167
67Poikilocytosis (HP:0004447)1.99094598
68Carpal bone hypoplasia (HP:0001498)1.98450810
69Bulbar palsy (HP:0001283)1.98294209
70High pitched voice (HP:0001620)1.98278094
71Lower limb amyotrophy (HP:0007210)1.97663805
72Back pain (HP:0003418)1.96993773
73Exercise-induced myalgia (HP:0003738)1.96973444
74Abnormality of the astrocytes (HP:0100707)1.96295596
75Astrocytoma (HP:0009592)1.96295596
76Shallow orbits (HP:0000586)1.95611277
77Areflexia of lower limbs (HP:0002522)1.95426417
78Slender long bone (HP:0003100)1.95378799
79Long palpebral fissure (HP:0000637)1.95180242
80Colon cancer (HP:0003003)1.95011938
81Scapular winging (HP:0003691)1.94742753
82Calcaneovalgus deformity (HP:0001848)1.94626463
83Spinal cord lesions (HP:0100561)1.92886058
84Syringomyelia (HP:0003396)1.92886058
85Ulnar deviation of the wrist (HP:0003049)1.92383114
86Genu recurvatum (HP:0002816)1.92202712
87Rimmed vacuoles (HP:0003805)1.92059303
88Elbow flexion contracture (HP:0002987)1.91435568
89Increased density of long bones (HP:0006392)1.89956693
90Impulsivity (HP:0100710)1.89542544
91Fatigue (HP:0012378)1.89291109
92Abnormality of the musculature of the pelvis (HP:0001469)1.88939175
93Abnormality of the hip-girdle musculature (HP:0001445)1.88939175
94Metatarsus adductus (HP:0001840)1.88370096
95Abnormality of the calf musculature (HP:0001430)1.88135331
96Muscle hypertrophy of the lower extremities (HP:0008968)1.87860376
97Abnormality of the thoracic spine (HP:0100711)1.86599472
98Prominent nose (HP:0000448)1.86461174
99Atresia of the external auditory canal (HP:0000413)1.85992486
100Breech presentation (HP:0001623)1.85873707
101EMG: myopathic abnormalities (HP:0003458)1.85314744
102Rhabdomyosarcoma (HP:0002859)1.84969920
103Thin ribs (HP:0000883)1.83610237
104Basal cell carcinoma (HP:0002671)1.82459860
105Slender build (HP:0001533)1.81877608
106Fragile skin (HP:0001030)1.81745548
107Abnormality of the umbilical cord (HP:0010881)1.79680314
108Chromosomal breakage induced by crosslinking agents (HP:0003221)1.79134548
109Sparse lateral eyebrow (HP:0005338)1.79105762
110Atrial fibrillation (HP:0005110)1.79043726
111Insomnia (HP:0100785)1.77940041
112Cerebral aneurysm (HP:0004944)1.77776666
113Cafe-au-lait spot (HP:0000957)1.77690214
114Shoulder girdle muscle weakness (HP:0003547)1.77065436
115Deformed tarsal bones (HP:0008119)1.76533087
116Supraventricular arrhythmia (HP:0005115)1.75778129
117Limb-girdle muscle weakness (HP:0003325)1.74767448
118Asymmetric septal hypertrophy (HP:0001670)1.74416828
119Supraventricular tachycardia (HP:0004755)1.73921632
120Limb-girdle muscle atrophy (HP:0003797)1.73730714
121Abnormal atrioventricular conduction (HP:0005150)1.73713317
122Degeneration of anterior horn cells (HP:0002398)1.72527779
123Abnormality of the anterior horn cell (HP:0006802)1.72527779
124Increased nuchal translucency (HP:0010880)1.72171581
125Biliary tract neoplasm (HP:0100574)1.72152174
126Abnormality of oral frenula (HP:0000190)1.71902359
127Heart block (HP:0012722)1.71823669
128Short palpebral fissure (HP:0012745)1.71804469
129Dilated cardiomyopathy (HP:0001644)1.70501817
130Primary atrial arrhythmia (HP:0001692)1.70407412
131Microvesicular hepatic steatosis (HP:0001414)1.70051661
132Medulloblastoma (HP:0002885)1.69781072
133Chromsome breakage (HP:0040012)1.69482740
134Absent thumb (HP:0009777)1.68851634
135Neoplasm of the pancreas (HP:0002894)1.68709381
136Malignant hyperthermia (HP:0002047)1.67813168
137Achilles tendon contracture (HP:0001771)1.66037675
138Wrist flexion contracture (HP:0001239)1.65599301
139Thoracic kyphosis (HP:0002942)1.65575430
140Abnormality of the heme biosynthetic pathway (HP:0010472)1.65049722
141Mildly elevated creatine phosphokinase (HP:0008180)1.64507162
142Nemaline bodies (HP:0003798)1.64452757
143Metaphyseal cupping (HP:0003021)1.64302200
144Myopathic facies (HP:0002058)1.63610051
145Glioma (HP:0009733)1.63478615
146Cholecystitis (HP:0001082)1.63169854
147Abnormal gallbladder physiology (HP:0012438)1.63169854
148Advanced eruption of teeth (HP:0006288)1.62628431
149Oral leukoplakia (HP:0002745)1.62604142
150Osteolytic defects of the phalanges of the hand (HP:0009771)1.61685398
151Osteolytic defects of the hand bones (HP:0009699)1.61685398
152Flat acetabular roof (HP:0003180)1.61202504
153Natal tooth (HP:0000695)1.60647433
154Diaphragmatic weakness (HP:0009113)1.59466225
155Abnormality of the fingertips (HP:0001211)1.57062081
156Deep philtrum (HP:0002002)1.55688510
157Deep palmar crease (HP:0006191)1.54598520
158Upper limb amyotrophy (HP:0009129)1.53979988
159Distal upper limb amyotrophy (HP:0007149)1.53979988
160Long eyelashes (HP:0000527)1.53263179

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.48466587
2TRIB33.44897500
3EEF2K3.20639863
4SMG13.16034288
5PRPF4B2.91828388
6TTN2.85630617
7CDK122.82985708
8CDC72.78210751
9NEK22.72996393
10BUB12.52983560
11MAP3K102.41463274
12IRAK32.41313222
13NEK12.40840800
14WEE12.34532107
15TTK2.12738496
16NME22.02964025
17MAP3K131.84341003
18LATS11.82353439
19SIK11.79953846
20EIF2AK11.74731937
21CDK41.73042394
22RPS6KB21.65895146
23EPHA21.62912699
24LATS21.59878635
25TSSK61.50415559
26MAP3K81.48043435
27STK31.46896873
28STK101.45101833
29MAP3K91.36079931
30PLK11.33090842
31STK41.32061136
32AURKB1.31232321
33ALK1.31064639
34DYRK31.28131470
35KSR21.28127280
36RPS6KA41.25128306
37MTOR1.24852482
38CDK71.20415060
39BRSK21.20087122
40MAP2K31.17287648
41TAOK21.17136943
42PDK31.15048227
43PDK41.15048227
44SRPK11.14227211
45FLT31.12426572
46MOS1.12280190
47SCYL21.06106822
48CHEK11.05958611
49BRAF1.03816217
50LRRK21.03268253
51DMPK1.02302756
52CHEK21.02082091
53STK38L0.99900868
54OBSCN0.98892116
55MAP3K140.98181703
56MET0.98055462
57PAK40.97990895
58PASK0.97203802
59ARAF0.96225031
60PBK0.95939205
61CDK60.95504008
62FGFR40.94663952
63ATR0.93024468
64PTK60.92720974
65PTK20.92270323
66ICK0.90324887
67PDGFRA0.89435256
68MST1R0.89169716
69MKNK20.85618866
70BCKDK0.84378572
71MKNK10.84376061
72CAMK1G0.83556988
73AURKA0.83125727
74ILK0.82559926
75BRD40.82295587
76MAPKAPK30.82009345
77PAK20.81269753
78PLK30.79865340
79PIM10.79585255
80STK240.79510699
81PNCK0.79168361
82AKT20.79029920
83TAOK10.77844415
84CDK20.76568967
85ATM0.72084374
86TLK10.70643765
87ZAK0.69369559
88TRPM70.68898472
89BMX0.68589125
90BRSK10.68422081
91MAP3K110.67709896
92PLK40.67402316
93MAP3K30.66930550
94TGFBR10.66049259
95MELK0.61488280
96CLK10.59710917
97CDK90.59567684
98CAMK1D0.56955888
99MARK30.55819051
100RAF10.55399312
101MAP4K10.55092303
102PDPK10.55046851
103MAPK120.55039464
104MAP3K10.54011144
105PAK10.52784307
106CDK80.52019298
107MAPK110.51897674
108MAP2K20.51494361
109ACVR1B0.51488636
110PHKG20.51377657
111PHKG10.51377657
112CDC42BPA0.50723299
113PIK3CG0.50649036
114ERN10.49845640
115MAP3K50.49111357
116TAF10.49091719
117RPS6KA10.48691380
118CSNK1E0.47694881
119TESK20.47381188
120CDK10.46923539
121PDK20.45319108
122CSNK2A20.45312668
123PRKCI0.42533309
124FGFR10.41570895
125RIPK10.40010258
126LMTK20.39288606
127RPS6KA20.38529770
128PDGFRB0.36919525
129RPS6KL10.36785667
130RPS6KC10.36785667
131NEK90.36164459
132MAP3K70.35082908
133PRKDC0.34865972
134KDR0.34595589
135CSNK1D0.34448661
136EIF2AK30.34336751
137PRKAA10.34159481

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.45922384
2* RNA transport_Homo sapiens_hsa030133.12223172
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07379375
4One carbon pool by folate_Homo sapiens_hsa006702.75594144
5Mismatch repair_Homo sapiens_hsa034302.71810084
6Spliceosome_Homo sapiens_hsa030402.71427664
7Cell cycle_Homo sapiens_hsa041102.67761683
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.47980039
9Ribosome_Homo sapiens_hsa030102.35437237
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.19885773
11Base excision repair_Homo sapiens_hsa034102.14845828
12RNA polymerase_Homo sapiens_hsa030202.12016509
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.11886735
14Nucleotide excision repair_Homo sapiens_hsa034201.98589228
15* mRNA surveillance pathway_Homo sapiens_hsa030151.85709470
16Vitamin B6 metabolism_Homo sapiens_hsa007501.85244000
17Homologous recombination_Homo sapiens_hsa034401.72722342
18p53 signaling pathway_Homo sapiens_hsa041151.68815924
19Biosynthesis of amino acids_Homo sapiens_hsa012301.53609028
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48592323
21Pyrimidine metabolism_Homo sapiens_hsa002401.47388798
22Carbon metabolism_Homo sapiens_hsa012001.45231143
23Other glycan degradation_Homo sapiens_hsa005111.40859190
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29162090
25Small cell lung cancer_Homo sapiens_hsa052221.28893872
26Proteasome_Homo sapiens_hsa030501.28360943
27* RNA degradation_Homo sapiens_hsa030181.25413070
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24108510
29Fanconi anemia pathway_Homo sapiens_hsa034601.23130336
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22659555
31B cell receptor signaling pathway_Homo sapiens_hsa046621.19538436
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15666392
33MicroRNAs in cancer_Homo sapiens_hsa052061.14839077
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13819700
35Viral carcinogenesis_Homo sapiens_hsa052031.12786927
36Chronic myeloid leukemia_Homo sapiens_hsa052201.10339587
37VEGF signaling pathway_Homo sapiens_hsa043701.09368014
38mTOR signaling pathway_Homo sapiens_hsa041501.08517071
39Lysine degradation_Homo sapiens_hsa003101.07193647
40Viral myocarditis_Homo sapiens_hsa054161.05490306
41Pentose phosphate pathway_Homo sapiens_hsa000301.03305658
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.01444371
43Basal transcription factors_Homo sapiens_hsa030221.01136292
44Prion diseases_Homo sapiens_hsa050201.00890339
45Selenocompound metabolism_Homo sapiens_hsa004501.00440940
46Bladder cancer_Homo sapiens_hsa052191.00031251
47HTLV-I infection_Homo sapiens_hsa051660.97298457
48Systemic lupus erythematosus_Homo sapiens_hsa053220.97115767
49Epstein-Barr virus infection_Homo sapiens_hsa051690.97083152
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96410832
51Thyroid cancer_Homo sapiens_hsa052160.95102526
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.94883381
53Dilated cardiomyopathy_Homo sapiens_hsa054140.94785696
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92296833
55Sulfur relay system_Homo sapiens_hsa041220.91786027
56Glioma_Homo sapiens_hsa052140.90816178
57Hippo signaling pathway_Homo sapiens_hsa043900.89706842
58ErbB signaling pathway_Homo sapiens_hsa040120.89421680
59Adherens junction_Homo sapiens_hsa045200.88582365
60Non-homologous end-joining_Homo sapiens_hsa034500.86098876
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.84940131
62Oocyte meiosis_Homo sapiens_hsa041140.81528171
63HIF-1 signaling pathway_Homo sapiens_hsa040660.81008597
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80402625
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79784299
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79227799
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78153921
68AMPK signaling pathway_Homo sapiens_hsa041520.76702641
69Herpes simplex infection_Homo sapiens_hsa051680.75778210
70Notch signaling pathway_Homo sapiens_hsa043300.74517160
71N-Glycan biosynthesis_Homo sapiens_hsa005100.73314476
72Acute myeloid leukemia_Homo sapiens_hsa052210.69654751
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69528913
74Antigen processing and presentation_Homo sapiens_hsa046120.68812997
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68578913
76Shigellosis_Homo sapiens_hsa051310.68354129
77Proteoglycans in cancer_Homo sapiens_hsa052050.68101003
78Insulin resistance_Homo sapiens_hsa049310.67435623
79Purine metabolism_Homo sapiens_hsa002300.67430368
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.67298207
81Focal adhesion_Homo sapiens_hsa045100.67188538
82Pyruvate metabolism_Homo sapiens_hsa006200.66390617
83Influenza A_Homo sapiens_hsa051640.65622411
84Tight junction_Homo sapiens_hsa045300.65522705
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65471362
86Basal cell carcinoma_Homo sapiens_hsa052170.64988285
87Non-small cell lung cancer_Homo sapiens_hsa052230.64498750
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64067066
89Insulin signaling pathway_Homo sapiens_hsa049100.63708096
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63387120
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.61526292
92Amoebiasis_Homo sapiens_hsa051460.60790180
93TGF-beta signaling pathway_Homo sapiens_hsa043500.60739314
94Hepatitis C_Homo sapiens_hsa051600.60711156
95Prolactin signaling pathway_Homo sapiens_hsa049170.60100222
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59892494
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59305611
98Apoptosis_Homo sapiens_hsa042100.57837515
99T cell receptor signaling pathway_Homo sapiens_hsa046600.55706986
100Fructose and mannose metabolism_Homo sapiens_hsa000510.55415569
101Arginine biosynthesis_Homo sapiens_hsa002200.55197563
102Measles_Homo sapiens_hsa051620.54932964
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54379658
104Prostate cancer_Homo sapiens_hsa052150.52878114
105Toxoplasmosis_Homo sapiens_hsa051450.52449111
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51926174
107ECM-receptor interaction_Homo sapiens_hsa045120.51661671
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50984520
109TNF signaling pathway_Homo sapiens_hsa046680.50554781
110Galactose metabolism_Homo sapiens_hsa000520.50211493
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50009442
112Endometrial cancer_Homo sapiens_hsa052130.48846921
113FoxO signaling pathway_Homo sapiens_hsa040680.48663014
114Colorectal cancer_Homo sapiens_hsa052100.47011730
115Glucagon signaling pathway_Homo sapiens_hsa049220.44857680
116Pathways in cancer_Homo sapiens_hsa052000.42976065
117Legionellosis_Homo sapiens_hsa051340.42040122
118Renal cell carcinoma_Homo sapiens_hsa052110.41839776
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.41541470
120Hepatitis B_Homo sapiens_hsa051610.39605838
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39454187
122Arginine and proline metabolism_Homo sapiens_hsa003300.39241118
123Pancreatic cancer_Homo sapiens_hsa052120.37455008
124Folate biosynthesis_Homo sapiens_hsa007900.36511776
125Drug metabolism - other enzymes_Homo sapiens_hsa009830.35581131
126Cardiac muscle contraction_Homo sapiens_hsa042600.35503531
127Melanoma_Homo sapiens_hsa052180.34519831

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