PABPC5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.35757994
2DNA double-strand break processing (GO:0000729)5.13607991
3interleukin-6-mediated signaling pathway (GO:0070102)4.74327367
4glutamate secretion (GO:0014047)4.47745391
5presynaptic membrane assembly (GO:0097105)4.43638566
6presynaptic membrane organization (GO:0097090)4.27160150
7synaptic vesicle exocytosis (GO:0016079)4.25801300
8transmission of nerve impulse (GO:0019226)4.23504476
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.22862948
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.20229459
11axonal fasciculation (GO:0007413)4.19531840
12neuron cell-cell adhesion (GO:0007158)4.18244867
13regulation of type B pancreatic cell apoptotic process (GO:2000674)4.14103535
14limb bud formation (GO:0060174)4.13584608
15protein localization to synapse (GO:0035418)4.09716584
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.04820879
17regulation of transmission of nerve impulse (GO:0051969)4.04055276
18neuron recognition (GO:0008038)4.03699035
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.97296183
20vocalization behavior (GO:0071625)3.96248263
21cellular potassium ion homeostasis (GO:0030007)3.92930714
22postsynaptic membrane organization (GO:0001941)3.89209813
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.87644206
24cerebral cortex neuron differentiation (GO:0021895)3.87205616
25regulation of synaptic vesicle exocytosis (GO:2000300)3.84814407
26somite development (GO:0061053)3.75570913
27relaxation of cardiac muscle (GO:0055119)3.60810426
28long-term synaptic potentiation (GO:0060291)3.60126537
29regulation of skeletal muscle contraction (GO:0014819)3.58177399
30negative regulation of neurotransmitter transport (GO:0051589)3.56910241
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.50287836
32negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.48836836
33ionotropic glutamate receptor signaling pathway (GO:0035235)3.47830468
34regulation of long-term neuronal synaptic plasticity (GO:0048169)3.44920408
35regulation of glutamate receptor signaling pathway (GO:1900449)3.44722511
36behavioral defense response (GO:0002209)3.43966315
37behavioral fear response (GO:0001662)3.43966315
38fear response (GO:0042596)3.42883158
39negative regulation of neurotransmitter secretion (GO:0046929)3.42727721
40gamma-aminobutyric acid transport (GO:0015812)3.40477848
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.38929742
42synaptic vesicle maturation (GO:0016188)3.38624250
43regulation of T-helper 2 cell differentiation (GO:0045628)3.34697679
44central nervous system projection neuron axonogenesis (GO:0021952)3.33962977
45regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32336347
46dentate gyrus development (GO:0021542)3.31979517
47regulation of neuronal synaptic plasticity (GO:0048168)3.31238096
48cerebellar granule cell differentiation (GO:0021707)3.26823110
49retinal ganglion cell axon guidance (GO:0031290)3.24696255
50response to dietary excess (GO:0002021)3.24568093
51negative regulation of axon extension involved in axon guidance (GO:0048843)3.24349801
52locomotory exploration behavior (GO:0035641)3.23811024
53positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.22531036
54calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.21066094
55pyrimidine nucleobase catabolic process (GO:0006208)3.20207840
56regulation of synaptic vesicle transport (GO:1902803)3.16253394
57dendrite morphogenesis (GO:0048813)3.15818158
58regulation of postsynaptic membrane potential (GO:0060078)3.15735998
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15708326
60membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.14696907
61ganglion development (GO:0061548)3.14492394
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14037126
63glutamate receptor signaling pathway (GO:0007215)3.13858928
64olfactory bulb development (GO:0021772)3.09907091
65atrial cardiac muscle cell action potential (GO:0086014)3.08098255
66synaptic transmission, glutamatergic (GO:0035249)3.07707098
67head development (GO:0060322)3.07595191
68regulation of vesicle fusion (GO:0031338)3.07182810
69neuron-neuron synaptic transmission (GO:0007270)3.06540645
70magnesium ion transport (GO:0015693)3.06457115
71behavioral response to nicotine (GO:0035095)3.03630242
72paraxial mesoderm development (GO:0048339)3.03221238
73neuronal action potential propagation (GO:0019227)3.02531957
74cerebral cortex radially oriented cell migration (GO:0021799)3.01926298
75exploration behavior (GO:0035640)3.01009289
76gamma-aminobutyric acid signaling pathway (GO:0007214)2.99861950
77cell migration in hindbrain (GO:0021535)2.98629767
78neurotransmitter-gated ion channel clustering (GO:0072578)2.96188943
79lateral sprouting from an epithelium (GO:0060601)2.95009611
80dendritic spine morphogenesis (GO:0060997)2.94923177
81proline transport (GO:0015824)2.93434547
82regulation of synapse structural plasticity (GO:0051823)2.93141126
83spinal cord development (GO:0021510)2.91608003
84response to nitrosative stress (GO:0051409)2.91037250
85multicellular organismal signaling (GO:0035637)2.88998897
86axon extension (GO:0048675)2.87320101
87neurotransmitter secretion (GO:0007269)2.85959624
88regulation of synaptic plasticity (GO:0048167)2.84057471
89synapse assembly (GO:0007416)2.83917694
90regulation of timing of cell differentiation (GO:0048505)2.83888903
91xenobiotic catabolic process (GO:0042178)2.83735445
92positive regulation of neurological system process (GO:0031646)2.82887609
93membrane assembly (GO:0071709)2.81285249
94negative regulation of cation channel activity (GO:2001258)2.81216453
95CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77674321
96membrane repolarization during action potential (GO:0086011)2.77435857
97positive regulation of neurotransmitter secretion (GO:0001956)2.76775263
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75844451
99regulation of axon extension involved in axon guidance (GO:0048841)2.74151814
100negative regulation of astrocyte differentiation (GO:0048712)2.73540253
101response to caffeine (GO:0031000)2.72752844
102generation of neurons (GO:0048699)2.72075669
103sympathetic nervous system development (GO:0048485)2.69446309
104positive regulation of synapse assembly (GO:0051965)2.69080030
105synaptic vesicle endocytosis (GO:0048488)2.68899586
106nucleobase catabolic process (GO:0046113)2.68535494
107serotonin metabolic process (GO:0042428)2.68486426
108negative regulation of axon guidance (GO:1902668)2.67345513
109nonmotile primary cilium assembly (GO:0035058)2.66995739
110positive regulation of membrane potential (GO:0045838)2.65987623
111muscle cell cellular homeostasis (GO:0046716)2.65949952
112central nervous system neuron axonogenesis (GO:0021955)2.65395786
113neuromuscular synaptic transmission (GO:0007274)2.64212234
114neural tube formation (GO:0001841)2.63513637
115neuron projection extension involved in neuron projection guidance (GO:1902284)2.62028588
116axon extension involved in axon guidance (GO:0048846)2.62028588
117negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61571882
118positive regulation of vesicle fusion (GO:0031340)2.61461495
119dendrite development (GO:0016358)2.60527109
120inner ear receptor stereocilium organization (GO:0060122)2.57633336
121glycosphingolipid biosynthetic process (GO:0006688)2.56165499
122behavioral response to ethanol (GO:0048149)2.55746937
123prostate gland growth (GO:0060736)2.54809625
124heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.54407355
125platelet dense granule organization (GO:0060155)2.54188802
126glomerulus development (GO:0032835)2.53291237
127positive regulation of neuroblast proliferation (GO:0002052)2.53195806
128regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52761289
129regulation of synapse assembly (GO:0051963)2.51748758
130positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49993825
131cellular response to BMP stimulus (GO:0071773)2.49205543
132response to BMP (GO:0071772)2.49205543
133intraciliary transport (GO:0042073)2.46446027
134epithelial cilium movement (GO:0003351)2.44494670
135neuron fate determination (GO:0048664)2.44046593
136positive regulation of mitochondrial fission (GO:0090141)2.43845755
137homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.40958530
138cerebral cortex cell migration (GO:0021795)2.40852615
139fatty acid elongation (GO:0030497)2.37496423
140positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.37193941
141negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37023053
142auditory behavior (GO:0031223)2.37011078
143mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.33172876
144negative chemotaxis (GO:0050919)2.33165945
145regulation of neurotransmitter uptake (GO:0051580)2.30572528
146cilium morphogenesis (GO:0060271)2.28165343
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.27596789
148cellular response to gonadotropin stimulus (GO:0071371)2.26177300
149smoothened signaling pathway (GO:0007224)2.25647584
150short-term memory (GO:0007614)2.24836023
151establishment of mitochondrion localization (GO:0051654)2.23275815
152cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.22859880
153brain morphogenesis (GO:0048854)2.21546746
154regulation of action potential (GO:0098900)2.21128742
155facial nerve structural organization (GO:0021612)2.20849692
156cranial nerve structural organization (GO:0021604)2.20702223
157outer ear morphogenesis (GO:0042473)2.20548445
158apical protein localization (GO:0045176)2.19005353
159limb development (GO:0060173)2.18866311
160appendage development (GO:0048736)2.18866311
161vascular smooth muscle contraction (GO:0014829)2.18772452
162regulation of respiratory system process (GO:0044065)2.18001460
163startle response (GO:0001964)2.17580259
164synapse organization (GO:0050808)2.17186590
165eye photoreceptor cell differentiation (GO:0001754)2.15983938
166photoreceptor cell differentiation (GO:0046530)2.15983938
167gastrulation with mouth forming second (GO:0001702)2.14842699
168regulation of protein kinase A signaling (GO:0010738)2.14434211
169kidney morphogenesis (GO:0060993)2.14278187
170positive regulation of amino acid transport (GO:0051957)2.14044274
171cilium organization (GO:0044782)2.13993778
172neurofilament cytoskeleton organization (GO:0060052)2.13624849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.68959800
2GBX2_23144817_ChIP-Seq_PC3_Human4.30276778
3TAF15_26573619_Chip-Seq_HEK293_Human3.06479031
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78424718
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.72674792
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.66915559
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56885564
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45553736
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37393652
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29641006
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29641006
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.26679890
13VDR_22108803_ChIP-Seq_LS180_Human2.26291662
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.21251169
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.21092807
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16637049
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.16142346
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15261633
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12334076
20DROSHA_22980978_ChIP-Seq_HELA_Human2.11849214
21REST_21632747_ChIP-Seq_MESCs_Mouse2.11009294
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06285604
23SALL1_21062744_ChIP-ChIP_HESCs_Human2.00639567
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96487451
25* EWS_26573619_Chip-Seq_HEK293_Human1.95648301
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.94253957
27* GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93595569
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93577202
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92611031
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91411611
31AR_21572438_ChIP-Seq_LNCaP_Human1.91130194
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90820018
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.84673377
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83696056
35SMAD4_21799915_ChIP-Seq_A2780_Human1.82222957
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.75877237
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74147438
38P300_19829295_ChIP-Seq_ESCs_Human1.71153766
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.69289808
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66936822
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66660260
42SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63806344
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63603428
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61344137
45* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61335355
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.60234315
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59977198
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.59385512
49* FUS_26573619_Chip-Seq_HEK293_Human1.55481335
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53956356
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.51767947
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49655381
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47970284
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.47493644
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46654413
56TP53_16413492_ChIP-PET_HCT116_Human1.44708921
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43949647
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.43185485
59CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42873167
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40637298
61IGF1R_20145208_ChIP-Seq_DFB_Human1.37802685
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.37105367
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36659056
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34131422
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33541784
66BCAT_22108803_ChIP-Seq_LS180_Human1.33259350
67AHR_22903824_ChIP-Seq_MCF-7_Human1.32896730
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.31547392
69* RNF2_27304074_Chip-Seq_NSC_Mouse1.30429955
70AR_25329375_ChIP-Seq_VCAP_Human1.30415688
71STAT3_23295773_ChIP-Seq_U87_Human1.30180800
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.28986436
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.28953439
74TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27042573
75TBX3_20139965_ChIP-Seq_ESCs_Mouse1.27026312
76TP53_18474530_ChIP-ChIP_U2OS_Human1.25375669
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25075455
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22358084
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20978935
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20978935
81ER_23166858_ChIP-Seq_MCF-7_Human1.20754866
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19677566
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19645672
84ERG_21242973_ChIP-ChIP_JURKAT_Human1.18172242
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.17434304
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17055278
87P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16398147
88TCF4_23295773_ChIP-Seq_U87_Human1.15818846
89NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14910323
90NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14910323
91AR_19668381_ChIP-Seq_PC3_Human1.13836814
92TCF4_22108803_ChIP-Seq_LS180_Human1.13149740
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.11984656
94PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11753611
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.10190883
96ZNF274_21170338_ChIP-Seq_K562_Hela1.09321341
97TAL1_26923725_Chip-Seq_HPCs_Mouse1.09236314
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09111088
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08965779
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08531873
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08351687
102RUNX2_22187159_ChIP-Seq_PCA_Human1.07998455
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07621293
104YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06714285
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06492084
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06251524
107KDM2B_26808549_Chip-Seq_REH_Human1.06220163
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05495419
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.04557860
110* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04418355
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.04363620
112TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04133593
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.03905607
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.03042959
115* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02973665
116SMAD3_21741376_ChIP-Seq_ESCs_Human1.02068771
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01588274
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00228385
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99966099
120WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99225438
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98378316
122JUN_21703547_ChIP-Seq_K562_Human0.98271458
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97927126
124CBP_20019798_ChIP-Seq_JUKART_Human0.97612590
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97612590
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.97312217
127RXR_22108803_ChIP-Seq_LS180_Human0.96901016
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.96653308
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.94971989
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94826468
131CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94567254

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.76077726
2MP0003880_abnormal_central_pattern4.40537583
3MP0004270_analgesia3.91023476
4MP0003635_abnormal_synaptic_transmissio3.32498761
5MP0001501_abnormal_sleep_pattern3.23866945
6MP0009745_abnormal_behavioral_response3.05218490
7MP0002063_abnormal_learning/memory/cond2.92317987
8MP0002064_seizures2.79976121
9MP0002734_abnormal_mechanical_nocicepti2.78855455
10MP0009780_abnormal_chondrocyte_physiolo2.71137537
11MP0001968_abnormal_touch/_nociception2.55188474
12MP0005503_abnormal_tendon_morphology2.54896564
13MP0001905_abnormal_dopamine_level2.52051646
14MP0004043_abnormal_pH_regulation2.50742697
15MP0002572_abnormal_emotion/affect_behav2.39849242
16MP0001486_abnormal_startle_reflex2.30716785
17MP0000778_abnormal_nervous_system2.23156388
18MP0002272_abnormal_nervous_system2.19774753
19MP0002736_abnormal_nociception_after2.17492513
20MP0002909_abnormal_adrenal_gland2.17339593
21MP0003690_abnormal_glial_cell2.12732835
22MP0009046_muscle_twitch2.09404005
23MP0002102_abnormal_ear_morphology2.07242392
24MP0005394_taste/olfaction_phenotype2.06274948
25MP0005499_abnormal_olfactory_system2.06274948
26MP0004924_abnormal_behavior1.97733753
27MP0005386_behavior/neurological_phenoty1.97733753
28MP0000049_abnormal_middle_ear1.96757458
29MP0010030_abnormal_orbit_morphology1.90631897
30MP0001970_abnormal_pain_threshold1.87941857
31MP0002557_abnormal_social/conspecific_i1.87547543
32MP0001440_abnormal_grooming_behavior1.84667409
33MP0002067_abnormal_sensory_capabilities1.82075210
34MP0004742_abnormal_vestibular_system1.81098870
35MP0002733_abnormal_thermal_nociception1.80884275
36MP0002837_dystrophic_cardiac_calcinosis1.77826997
37MP0002938_white_spotting1.77197944
38MP0006276_abnormal_autonomic_nervous1.70430813
39MP0003122_maternal_imprinting1.69382504
40MP0001299_abnormal_eye_distance/1.68939133
41MP0005646_abnormal_pituitary_gland1.68531880
42MP0002735_abnormal_chemical_nociception1.68512704
43MP0002184_abnormal_innervation1.66168094
44MP0004885_abnormal_endolymph1.64614363
45MP0008875_abnormal_xenobiotic_pharmacok1.59030884
46MP0000537_abnormal_urethra_morphology1.58990411
47MP0003121_genomic_imprinting1.57885568
48MP0008789_abnormal_olfactory_epithelium1.57589901
49MP0003937_abnormal_limbs/digits/tail_de1.56456988
50MP0005253_abnormal_eye_physiology1.56205932
51MP0001984_abnormal_olfaction1.55965535
52MP0005248_abnormal_Harderian_gland1.51958328
53MP0000534_abnormal_ureter_morphology1.51504001
54MP0002090_abnormal_vision1.47583307
55MP0003633_abnormal_nervous_system1.47477110
56MP0001529_abnormal_vocalization1.45102571
57MP0003119_abnormal_digestive_system1.44673316
58MP0005171_absent_coat_pigmentation1.41175366
59MP0004811_abnormal_neuron_physiology1.39084292
60MP0000516_abnormal_urinary_system1.35776578
61MP0005367_renal/urinary_system_phenotyp1.35776578
62MP0003136_yellow_coat_color1.34315843
63MP0005423_abnormal_somatic_nervous1.34284074
64MP0008569_lethality_at_weaning1.34079209
65MP0002876_abnormal_thyroid_physiology1.33294191
66MP0003329_amyloid_beta_deposits1.32855598
67MP0002882_abnormal_neuron_morphology1.31463586
68MP0003879_abnormal_hair_cell1.25825317
69MP0002638_abnormal_pupillary_reflex1.25537607
70MP0002822_catalepsy1.25375993
71MP0001293_anophthalmia1.23064819
72MP0001188_hyperpigmentation1.22378920
73MP0002066_abnormal_motor_capabilities/c1.22179105
74MP0004145_abnormal_muscle_electrophysio1.21953891
75MP0000955_abnormal_spinal_cord1.21313069
76MP0003137_abnormal_impulse_conducting1.19467671
77MP0003567_abnormal_fetal_cardiomyocyte1.17567719
78MP0003385_abnormal_body_wall1.17483140
79MP0005535_abnormal_body_temperature1.16086581
80MP0004858_abnormal_nervous_system1.15322898
81MP0003755_abnormal_palate_morphology1.14297715
82MP0005391_vision/eye_phenotype1.13647229
83MP0009250_abnormal_appendicular_skeleto1.12752396
84MP0005551_abnormal_eye_electrophysiolog1.11447116
85MP0002295_abnormal_pulmonary_circulatio1.10938050
86MP0000569_abnormal_digit_pigmentation1.10415625
87MP0003634_abnormal_glial_cell1.09767522
88MP0003631_nervous_system_phenotype1.09630327
89MP0003315_abnormal_perineum_morphology1.08315253
90MP0002108_abnormal_muscle_morphology1.08002017
91MP0005379_endocrine/exocrine_gland_phen1.07294917
92MP0004215_abnormal_myocardial_fiber1.06317854
93MP0003942_abnormal_urinary_system1.04788949
94MP0005187_abnormal_penis_morphology1.01036522
95MP0001502_abnormal_circadian_rhythm0.99919436
96MP0004085_abnormal_heartbeat0.99810287
97MP0000631_abnormal_neuroendocrine_gland0.98957136
98MP0004142_abnormal_muscle_tone0.97816542
99MP0004272_abnormal_basement_membrane0.96437156
100MP0000372_irregular_coat_pigmentation0.95829178
101MP0005623_abnormal_meninges_morphology0.94932218
102MP0002152_abnormal_brain_morphology0.93742698
103MP0000462_abnormal_digestive_system0.93653689
104MP0000920_abnormal_myelination0.93600766
105MP0008872_abnormal_physiological_respon0.91621419
106MP0002282_abnormal_trachea_morphology0.91014687
107MP0010386_abnormal_urinary_bladder0.90305395
108MP0001485_abnormal_pinna_reflex0.90163263
109MP0002653_abnormal_ependyma_morphology0.90106295
110MP0005409_darkened_coat_color0.89850466
111MP0002229_neurodegeneration0.89777658
112MP0001963_abnormal_hearing_physiology0.89621484
113MP0002751_abnormal_autonomic_nervous0.88879571
114MP0009384_cardiac_valve_regurgitation0.87192502
115MP0005275_abnormal_skin_tensile0.86416317
116MP0003195_calcinosis0.85965562
117MP0008877_abnormal_DNA_methylation0.84533849
118MP0008995_early_reproductive_senescence0.84352219
119MP0006072_abnormal_retinal_apoptosis0.83945366
120MP0003890_abnormal_embryonic-extraembry0.81778185
121MP0002069_abnormal_eating/drinking_beha0.81776707
122MP0005645_abnormal_hypothalamus_physiol0.81068229
123MP0003283_abnormal_digestive_organ0.81060868
124MP0003787_abnormal_imprinting0.78082078
125MP0006292_abnormal_olfactory_placode0.77506578
126MP0001177_atelectasis0.76866016
127MP0006082_CNS_inflammation0.75891831
128MP0002752_abnormal_somatic_nervous0.73309516
129MP0000013_abnormal_adipose_tissue0.72413986
130MP0002234_abnormal_pharynx_morphology0.70206021
131MP0005164_abnormal_response_to0.69188820
132MP0002332_abnormal_exercise_endurance0.65426744
133MP0002233_abnormal_nose_morphology0.65410486
134MP0001943_abnormal_respiration0.63864298
135MP0000026_abnormal_inner_ear0.60876951
136MP0001944_abnormal_pancreas_morphology0.59318342
137MP0009379_abnormal_foot_pigmentation0.58924211
138MP0003938_abnormal_ear_development0.57921822
139MP0003861_abnormal_nervous_system0.54299552
140MP0004133_heterotaxia0.53653516
141MP0001348_abnormal_lacrimal_gland0.52719358

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.61714773
2Epileptic encephalopathy (HP:0200134)5.34888090
3Myokymia (HP:0002411)5.24545400
4Focal seizures (HP:0007359)4.32973302
5Hyperventilation (HP:0002883)4.20799842
6Visual hallucinations (HP:0002367)4.09142780
7Glucose intolerance (HP:0000833)3.81614364
8Excessive salivation (HP:0003781)3.72193452
9Drooling (HP:0002307)3.72193452
10Abnormality of the corticospinal tract (HP:0002492)3.60871999
11Broad-based gait (HP:0002136)3.51357960
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.46928363
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.46928363
14Termporal pattern (HP:0011008)3.45996618
15Insidious onset (HP:0003587)3.45996618
16Atonic seizures (HP:0010819)3.40462436
17Absence seizures (HP:0002121)3.35864873
18Progressive cerebellar ataxia (HP:0002073)3.24020941
19Dialeptic seizures (HP:0011146)3.20281639
20Generalized tonic-clonic seizures (HP:0002069)3.18178127
21Supranuclear gaze palsy (HP:0000605)3.12410672
22True hermaphroditism (HP:0010459)3.11672875
23Agitation (HP:0000713)3.06097016
24Blue irides (HP:0000635)3.01835594
25Cerebral inclusion bodies (HP:0100314)2.97140891
26Action tremor (HP:0002345)2.95790902
27Neurofibrillary tangles (HP:0002185)2.93198488
28Hyperthyroidism (HP:0000836)2.92364713
29Epileptiform EEG discharges (HP:0011182)2.91255131
30Febrile seizures (HP:0002373)2.90557407
31Postural tremor (HP:0002174)2.87335408
32Pancreatic fibrosis (HP:0100732)2.86411531
33Abnormality of the labia minora (HP:0012880)2.81618817
34Amblyopia (HP:0000646)2.81206026
35Pancreatic cysts (HP:0001737)2.79506374
36Morphological abnormality of the middle ear (HP:0008609)2.75143463
37EEG with generalized epileptiform discharges (HP:0011198)2.74631377
38Truncal ataxia (HP:0002078)2.71895688
39Gaze-evoked nystagmus (HP:0000640)2.67608805
40Abnormal glucose tolerance (HP:0001952)2.66102448
41Anxiety (HP:0000739)2.65871940
42Pheochromocytoma (HP:0002666)2.61942961
43Hypsarrhythmia (HP:0002521)2.61454330
44Poor eye contact (HP:0000817)2.59241149
45Scanning speech (HP:0002168)2.58360766
46Abnormality of the ischium (HP:0003174)2.57511284
47Persistence of primary teeth (HP:0006335)2.55043446
48Septo-optic dysplasia (HP:0100842)2.52639722
49Impaired vibration sensation in the lower limbs (HP:0002166)2.48530137
50Abnormality of salivation (HP:0100755)2.46495840
51Myelomeningocele (HP:0002475)2.45487913
52Urinary bladder sphincter dysfunction (HP:0002839)2.42370920
53Torticollis (HP:0000473)2.38458339
54Spastic gait (HP:0002064)2.38329408
55Dysmetria (HP:0001310)2.36116210
56Dysmetric saccades (HP:0000641)2.34530327
57Neuroendocrine neoplasm (HP:0100634)2.33491496
58Cutaneous syndactyly (HP:0012725)2.30581624
59Hypoplasia of the thymus (HP:0000778)2.30508834
60Renal hypoplasia (HP:0000089)2.29247088
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.28416813
62Diplopia (HP:0000651)2.27812798
63Abnormality of binocular vision (HP:0011514)2.27812798
64Anophthalmia (HP:0000528)2.26775493
65Ankle clonus (HP:0011448)2.26595862
66Genital tract atresia (HP:0001827)2.25261412
67Slender build (HP:0001533)2.24693561
68Intestinal atresia (HP:0011100)2.23170259
69Hydroureter (HP:0000072)2.22228940
70Optic nerve hypoplasia (HP:0000609)2.21458239
71Impaired smooth pursuit (HP:0007772)2.21156497
72Short tibia (HP:0005736)2.21155537
73Bifid scrotum (HP:0000048)2.21047385
74Hypoplastic ischia (HP:0003175)2.20221661
75Abnormality of the pubic bones (HP:0003172)2.20114338
76Preaxial foot polydactyly (HP:0001841)2.18953279
77Depression (HP:0000716)2.18766607
78Vaginal atresia (HP:0000148)2.18502669
79Syncope (HP:0001279)2.17877013
80Bifid tongue (HP:0010297)2.16566574
81Abnormal eating behavior (HP:0100738)2.16531744
82Mutism (HP:0002300)2.14766757
83Labial hypoplasia (HP:0000066)2.13727037
84Occipital encephalocele (HP:0002085)2.12916880
85Nephronophthisis (HP:0000090)2.11248988
86Progressive inability to walk (HP:0002505)2.10996576
87Anencephaly (HP:0002323)2.10807254
88Papilledema (HP:0001085)2.09824164
89Postaxial hand polydactyly (HP:0001162)2.09246818
90Impaired social interactions (HP:0000735)2.08867338
91Abnormal social behavior (HP:0012433)2.08867338
92Limb dystonia (HP:0002451)2.07490218
93Gait imbalance (HP:0002141)2.07376866
94Protruding tongue (HP:0010808)2.07262715
95Hepatoblastoma (HP:0002884)2.07225431
96Impaired vibratory sensation (HP:0002495)2.06787981
97Abnormality of midbrain morphology (HP:0002418)2.06450183
98Molar tooth sign on MRI (HP:0002419)2.06450183
99Sensory axonal neuropathy (HP:0003390)2.06179477
100Dysdiadochokinesis (HP:0002075)2.05376773
101Focal dystonia (HP:0004373)2.04866128
102Medial flaring of the eyebrow (HP:0010747)2.03970405
103Abnormality of the frontal sinuses (HP:0002687)2.03119945
104Inability to walk (HP:0002540)2.02942551
105Generalized hypopigmentation of hair (HP:0011358)2.02676230
106Lissencephaly (HP:0001339)2.01926123
107Fair hair (HP:0002286)2.01795551
108Craniofacial dystonia (HP:0012179)2.01212953
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.99570111
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99512141
111Short 4th metacarpal (HP:0010044)1.99512141
112Akinesia (HP:0002304)1.99159825
113Postaxial foot polydactyly (HP:0001830)1.97452010
114Scrotal hypoplasia (HP:0000046)1.97080852
115Midline defect of the nose (HP:0004122)1.96706654
116Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94465856
117Preaxial hand polydactyly (HP:0001177)1.93866688
118Specific learning disability (HP:0001328)1.93426917
119Cutaneous finger syndactyly (HP:0010554)1.92777783
120Hypoventilation (HP:0002791)1.92688678
121Bowel incontinence (HP:0002607)1.92162183
122Gait ataxia (HP:0002066)1.91941072
123Ulnar claw (HP:0001178)1.91915598
124Morphological abnormality of the pyramidal tract (HP:0002062)1.90567164
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90556027
126Absent septum pellucidum (HP:0001331)1.90226812
127Lower limb muscle weakness (HP:0007340)1.90018847
128Broad metatarsal (HP:0001783)1.89646611
129Urinary urgency (HP:0000012)1.89302886
130Aqueductal stenosis (HP:0002410)1.89209192
131Stereotypic behavior (HP:0000733)1.89054391
132Abnormality of the antihelix (HP:0009738)1.88147431
133Abnormality of ocular smooth pursuit (HP:0000617)1.87560998
134Congenital primary aphakia (HP:0007707)1.86721596
135Hypoplastic female external genitalia (HP:0012815)1.86319089
136Atelectasis (HP:0100750)1.86254303
137Abnormality of the metopic suture (HP:0005556)1.85922861
138Hypoplastic labia majora (HP:0000059)1.85862683
139Absent speech (HP:0001344)1.85716119
140Pachygyria (HP:0001302)1.85493252
141Cortical dysplasia (HP:0002539)1.84926106
142Generalized myoclonic seizures (HP:0002123)1.82973796
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82836092
144Aplasia/Hypoplasia of the sternum (HP:0006714)1.82260153
145Micropenis (HP:0000054)1.82047811
146Abnormal EKG (HP:0003115)1.81750805
147Psychosis (HP:0000709)1.81265794
148Abnormality of saccadic eye movements (HP:0000570)1.81059309
149Clumsiness (HP:0002312)1.80846547
150Sleep apnea (HP:0010535)1.80371079
151Bilateral microphthalmos (HP:0007633)1.80075562
152Prominent supraorbital ridges (HP:0000336)1.79896373
153Polyphagia (HP:0002591)1.79844070
154Nephrogenic diabetes insipidus (HP:0009806)1.79238065
155Colon cancer (HP:0003003)1.78962557
156Thyroid-stimulating hormone excess (HP:0002925)1.78706852
157Tented upper lip vermilion (HP:0010804)1.77339195
158Abnormality of the labia majora (HP:0012881)1.76597391
159Broad foot (HP:0001769)1.76405090
160Restlessness (HP:0000711)1.76278841
161Open mouth (HP:0000194)1.75072637
162Hemivertebrae (HP:0002937)1.74202170
163Abnormal large intestine physiology (HP:0012700)1.73335745
164Choanal stenosis (HP:0000452)1.73145267
165Hemiparesis (HP:0001269)1.72579552
166Absent eyebrow (HP:0002223)1.71465527
167Cystic liver disease (HP:0006706)1.69201008
168Severe Myopia (HP:0011003)1.66568621
169Narrow forehead (HP:0000341)1.65519942
170Exotropia (HP:0000577)1.65050625
171Spastic tetraplegia (HP:0002510)1.64920402
172Neoplasm of the oral cavity (HP:0100649)1.63275852
173Keratoconus (HP:0000563)1.62807792
174Increased corneal curvature (HP:0100692)1.62807792
175Long clavicles (HP:0000890)1.62709190
176Sclerocornea (HP:0000647)1.62301257
177Chronic hepatic failure (HP:0100626)1.62291028
178Chorioretinal coloboma (HP:0000567)1.61646865
179Limb-girdle muscle weakness (HP:0003325)1.60515961
180Abnormality of the septum pellucidum (HP:0007375)1.60389662
181Short hallux (HP:0010109)1.59968583
182Intellectual disability, moderate (HP:0002342)1.59781833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K44.63868703
2NTRK33.74977260
3CASK3.60079214
4MARK13.48024252
5EPHA43.18160148
6BMPR23.06202201
7DAPK22.96089236
8TRIM282.78630182
9EPHA32.53937946
10MAP2K72.16656952
11PINK12.06510646
12MAP3K122.03407009
13EPHB11.86196679
14MAP3K21.85667318
15CDK191.77426216
16MKNK21.72700567
17MAP3K91.72087992
18MINK11.70271463
19PLK21.64231244
20MUSK1.58486160
21FRK1.56310265
22MKNK11.51653203
23DAPK11.46746719
24OXSR11.46514299
25STK38L1.43762562
26ERBB31.42901872
27PAK31.42698975
28BMPR1B1.40471001
29WEE11.39438256
30RIPK41.37790657
31NTRK11.36773080
32GRK11.36166921
33MAP2K41.30680062
34PAK61.29518106
35MAPK131.24964951
36TNIK1.24686282
37CDK51.23567088
38BCR1.22873308
39GRK51.21776821
40NTRK21.21696748
41NUAK11.17753979
42IRAK11.13418267
43NME11.11982977
44FER1.11725615
45ADRBK21.06020482
46PRPF4B1.05705019
47FGFR21.03789470
48OBSCN1.01621165
49INSRR0.96162235
50WNK40.95230069
51STK390.94870339
52UHMK10.93724763
53CAMK2A0.93616380
54SGK4940.92270148
55SGK2230.92270148
56RET0.89130368
57PRKCE0.88385951
58DYRK20.88005485
59PRKD30.85071021
60PRKCG0.82524905
61SIK20.82404034
62KSR10.80578901
63SRPK10.80420817
64CAMK2B0.79068794
65MAPKAPK50.78382363
66WNK30.77656504
67PLK30.77041393
68HIPK20.76843912
69MAPK150.76412887
70PHKG20.73964207
71PHKG10.73964207
72SIK30.72837475
73ZAK0.72783157
74LATS10.72685243
75CSNK1G10.69259196
76NEK10.68475847
77FGFR10.67950866
78CSNK1G20.67727562
79MAP3K60.64347010
80MAP3K10.63919784
81PLK40.63736058
82SGK20.61909987
83MAP4K20.59956162
84PTK2B0.59620539
85LIMK10.59497030
86SGK10.59263540
87AKT30.59223444
88FGR0.58300764
89CAMKK10.57253051
90DYRK30.57003065
91GRK70.55931120
92RPS6KA40.55676288
93PNCK0.55616641
94CDK140.55495189
95TGFBR10.55397283
96CAMK2D0.55290090
97FES0.54737792
98MST40.54572249
99ROCK10.54509189
100CAMKK20.53666063
101DYRK1A0.53519274
102MYLK0.52614416
103CSNK1G30.52575910
104TSSK60.52243117
105STK110.49962945
106CCNB10.49817908
107CSNK1A1L0.49226782
108NLK0.48560351
109CDK180.48405322
110PKN20.47881536
111CAMK10.47300892
112WNK10.46332496
113ROCK20.46314469
114ADRBK10.46127323
115PRKCH0.46089568
116PKN10.45048301
117MAPK70.44772968
118BRD40.44743226
119CDK150.43931628
120CDC42BPA0.43927279
121FGFR40.43715935
122EPHB20.43445124
123KSR20.42235496
124DMPK0.41891687
125CDK30.41768443
126STK380.41652922
127PRKCZ0.41499080
128DDR20.40960743
129CSNK1A10.40706781
130SGK30.40309664
131RPS6KA20.39394916
132LATS20.38632091
133FGFR30.38347442
134PIK3CA0.38197232
135BRSK20.37848500
136PRKACA0.37393802
137PRKACB0.37279502
138CAMK40.36701482
139CSNK1D0.34180547
140FLT30.30022370
141PRKG10.29702566
142CSNK1E0.27021891

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29764149
2Synaptic vesicle cycle_Homo sapiens_hsa047213.04556027
3Amphetamine addiction_Homo sapiens_hsa050312.53867728
4Collecting duct acid secretion_Homo sapiens_hsa049662.48098800
5Circadian entrainment_Homo sapiens_hsa047132.47749707
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41428218
7Long-term potentiation_Homo sapiens_hsa047202.35420488
8Morphine addiction_Homo sapiens_hsa050322.27579107
9GABAergic synapse_Homo sapiens_hsa047272.21444105
10Glutamatergic synapse_Homo sapiens_hsa047242.18101910
11Insulin secretion_Homo sapiens_hsa049112.09909993
12Dopaminergic synapse_Homo sapiens_hsa047282.04741794
13Serotonergic synapse_Homo sapiens_hsa047262.04203472
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.01357969
15Protein export_Homo sapiens_hsa030601.99775294
16Renin secretion_Homo sapiens_hsa049241.96463214
17Gastric acid secretion_Homo sapiens_hsa049711.90842560
18Olfactory transduction_Homo sapiens_hsa047401.90761185
19Cocaine addiction_Homo sapiens_hsa050301.90120461
20Vibrio cholerae infection_Homo sapiens_hsa051101.83680415
21Hedgehog signaling pathway_Homo sapiens_hsa043401.82063524
22Taste transduction_Homo sapiens_hsa047421.81781349
23Cholinergic synapse_Homo sapiens_hsa047251.76315217
24Basal cell carcinoma_Homo sapiens_hsa052171.76141587
25Salivary secretion_Homo sapiens_hsa049701.74228370
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69805183
27Long-term depression_Homo sapiens_hsa047301.63491554
28Axon guidance_Homo sapiens_hsa043601.60588672
29Propanoate metabolism_Homo sapiens_hsa006401.54080274
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51460391
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49288014
32African trypanosomiasis_Homo sapiens_hsa051431.49032419
33RNA polymerase_Homo sapiens_hsa030201.44699802
34Hippo signaling pathway_Homo sapiens_hsa043901.42535251
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.40327703
36Nitrogen metabolism_Homo sapiens_hsa009101.36975546
37Oxytocin signaling pathway_Homo sapiens_hsa049211.36963713
38GnRH signaling pathway_Homo sapiens_hsa049121.34358506
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34182015
40Prion diseases_Homo sapiens_hsa050201.33863702
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33231751
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33112344
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30473864
44Gap junction_Homo sapiens_hsa045401.29007955
45Calcium signaling pathway_Homo sapiens_hsa040201.25202845
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.23932174
47Type II diabetes mellitus_Homo sapiens_hsa049301.21634285
48Fatty acid elongation_Homo sapiens_hsa000621.21073359
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18703336
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18053223
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16590931
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16498650
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.13733133
54Rheumatoid arthritis_Homo sapiens_hsa053231.13020079
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08952194
56TGF-beta signaling pathway_Homo sapiens_hsa043501.05749414
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05002571
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.00818026
59Chemical carcinogenesis_Homo sapiens_hsa052040.99179140
60cAMP signaling pathway_Homo sapiens_hsa040240.98239756
61Graft-versus-host disease_Homo sapiens_hsa053320.97495634
62Sulfur metabolism_Homo sapiens_hsa009200.96615363
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95098800
64Oxidative phosphorylation_Homo sapiens_hsa001900.94967416
65Fanconi anemia pathway_Homo sapiens_hsa034600.91553485
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90500372
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89600063
68Selenocompound metabolism_Homo sapiens_hsa004500.88878388
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88125641
70Oocyte meiosis_Homo sapiens_hsa041140.85902502
71Melanogenesis_Homo sapiens_hsa049160.84599519
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84201351
73Estrogen signaling pathway_Homo sapiens_hsa049150.83722616
74Caffeine metabolism_Homo sapiens_hsa002320.81631698
75Protein digestion and absorption_Homo sapiens_hsa049740.80733029
76MAPK signaling pathway_Homo sapiens_hsa040100.80511603
77Peroxisome_Homo sapiens_hsa041460.77342897
78Glioma_Homo sapiens_hsa052140.76810164
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75391287
80Alzheimers disease_Homo sapiens_hsa050100.73580499
81ErbB signaling pathway_Homo sapiens_hsa040120.73248628
82Butanoate metabolism_Homo sapiens_hsa006500.73176953
83Cardiac muscle contraction_Homo sapiens_hsa042600.72610695
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72450743
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71002283
86ECM-receptor interaction_Homo sapiens_hsa045120.69206916
87Basal transcription factors_Homo sapiens_hsa030220.67349558
88Pancreatic secretion_Homo sapiens_hsa049720.66981014
89Huntingtons disease_Homo sapiens_hsa050160.66835656
90Phototransduction_Homo sapiens_hsa047440.65437248
91Melanoma_Homo sapiens_hsa052180.65428547
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65393939
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63999406
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63288338
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.63223826
96Thyroid hormone synthesis_Homo sapiens_hsa049180.62531060
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61587062
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60758097
99Adherens junction_Homo sapiens_hsa045200.57648941
100Linoleic acid metabolism_Homo sapiens_hsa005910.57163349
101Tryptophan metabolism_Homo sapiens_hsa003800.56076060
102Mineral absorption_Homo sapiens_hsa049780.54455113
103Dilated cardiomyopathy_Homo sapiens_hsa054140.54271891
104beta-Alanine metabolism_Homo sapiens_hsa004100.54232464
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.54176791
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53795841
107Ras signaling pathway_Homo sapiens_hsa040140.50767447
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49682980
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49534979
110Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49102659
111Phagosome_Homo sapiens_hsa041450.48643555
112Fatty acid metabolism_Homo sapiens_hsa012120.46843617
113Circadian rhythm_Homo sapiens_hsa047100.46524053
114Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46434353
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45665234
116Alcoholism_Homo sapiens_hsa050340.45619752
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.45014789
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.44958452
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44495340
120* RNA degradation_Homo sapiens_hsa030180.44484525
121Purine metabolism_Homo sapiens_hsa002300.43574812
122FoxO signaling pathway_Homo sapiens_hsa040680.41340862
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.40697067
124* RNA transport_Homo sapiens_hsa030130.40618110
125Pertussis_Homo sapiens_hsa051330.40332263
126Steroid biosynthesis_Homo sapiens_hsa001000.39980960
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39887050
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38405490
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.37533651
130Dorso-ventral axis formation_Homo sapiens_hsa043200.35174842
131Wnt signaling pathway_Homo sapiens_hsa043100.33557659
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.32925666
133Choline metabolism in cancer_Homo sapiens_hsa052310.32696544
134Parkinsons disease_Homo sapiens_hsa050120.32355283
135Phenylalanine metabolism_Homo sapiens_hsa003600.31961195
136Amoebiasis_Homo sapiens_hsa051460.31236387
137Bile secretion_Homo sapiens_hsa049760.30087466
138Ether lipid metabolism_Homo sapiens_hsa005650.29621813
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28916860
140Glucagon signaling pathway_Homo sapiens_hsa049220.28044428
141Ovarian steroidogenesis_Homo sapiens_hsa049130.27773866
142Renal cell carcinoma_Homo sapiens_hsa052110.27425336
143Rap1 signaling pathway_Homo sapiens_hsa040150.27010340
144Tight junction_Homo sapiens_hsa045300.26086137
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25994025
146Salmonella infection_Homo sapiens_hsa051320.25596026

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