PABPN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of translational fidelity (GO:0006450)8.16591592
2ribosomal small subunit assembly (GO:0000028)6.56330196
3cellular protein complex disassembly (GO:0043624)5.64754640
4* viral life cycle (GO:0019058)5.17132807
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.13953419
6protein targeting to ER (GO:0045047)5.05869066
7cotranslational protein targeting to membrane (GO:0006613)5.05717261
8negative regulation of viral release from host cell (GO:1902187)4.84257738
9establishment of protein localization to endoplasmic reticulum (GO:0072599)4.77179942
10macromolecular complex disassembly (GO:0032984)4.76641085
11protein localization to endoplasmic reticulum (GO:0070972)4.60182618
12mitotic metaphase plate congression (GO:0007080)4.58571174
13pre-miRNA processing (GO:0031054)4.48957511
14protein localization to kinetochore (GO:0034501)4.33247003
15negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.26979485
16planar cell polarity pathway involved in neural tube closure (GO:0090179)4.23232882
17heterochromatin organization (GO:0070828)4.08846130
18regulation of translational elongation (GO:0006448)3.96867222
19negative regulation of RNA splicing (GO:0033119)3.95850146
20regulation of posttranscriptional gene silencing (GO:0060147)3.95570896
21regulation of gene silencing by miRNA (GO:0060964)3.95570896
22regulation of gene silencing by RNA (GO:0060966)3.95570896
23protein localization to chromosome, centromeric region (GO:0071459)3.93162885
24negative regulation of histone methylation (GO:0031061)3.81857638
25negative regulation of mRNA processing (GO:0050686)3.81245687
26nuclear-transcribed mRNA catabolic process (GO:0000956)3.78053822
27peptidyl-arginine omega-N-methylation (GO:0035247)3.77472816
28maturation of SSU-rRNA (GO:0030490)3.71166509
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.68130118
30peptidyl-arginine methylation (GO:0018216)3.64645612
31peptidyl-arginine N-methylation (GO:0035246)3.64645612
32mRNA catabolic process (GO:0006402)3.63842692
33metaphase plate congression (GO:0051310)3.63338367
34paraxial mesoderm development (GO:0048339)3.63274310
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.62473201
36protein targeting to membrane (GO:0006612)3.60941109
37phosphatidylserine acyl-chain remodeling (GO:0036150)3.60388527
38DNA unwinding involved in DNA replication (GO:0006268)3.59688672
39convergent extension (GO:0060026)3.59632779
40negative regulation of viral entry into host cell (GO:0046597)3.58518857
41mRNA splice site selection (GO:0006376)3.58377589
42intracellular estrogen receptor signaling pathway (GO:0030520)3.54574861
43regulation of sister chromatid cohesion (GO:0007063)3.54354171
44RNA catabolic process (GO:0006401)3.45844318
45positive regulation of chromosome segregation (GO:0051984)3.45445116
46mitotic sister chromatid segregation (GO:0000070)3.39079754
47negative regulation of mRNA metabolic process (GO:1903312)3.38322979
48regulation of spindle organization (GO:0090224)3.32537442
49regulation of RNA export from nucleus (GO:0046831)3.31912519
50viral transcription (GO:0019083)3.30512038
51histone arginine methylation (GO:0034969)3.26398322
52G1 DNA damage checkpoint (GO:0044783)3.24495714
53histone H2B ubiquitination (GO:0033523)3.23058722
54histone H4-K12 acetylation (GO:0043983)3.20663711
55regulation of hippo signaling (GO:0035330)3.20630254
56translational termination (GO:0006415)3.19873468
57regulation of meiosis I (GO:0060631)3.18944319
58histone H2A monoubiquitination (GO:0035518)3.18164053
59chromatin silencing (GO:0006342)3.17820306
60regulation of mitotic spindle organization (GO:0060236)3.16483147
61phosphatidylinositol acyl-chain remodeling (GO:0036149)3.16183425
62regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.10503344
63negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.09771138
64hematopoietic stem cell differentiation (GO:0060218)3.09417085
65* mRNA splicing, via spliceosome (GO:0000398)3.08646255
66* RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.08646255
67DNA replication checkpoint (GO:0000076)3.07835582
68sister chromatid segregation (GO:0000819)3.06867110
69protein localization to chromosome (GO:0034502)3.06015091
70* RNA splicing, via transesterification reactions (GO:0000375)3.05583680
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.04468117
72regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02689129
73protein complex localization (GO:0031503)3.02600846
74translational initiation (GO:0006413)3.02410011
75inner cell mass cell proliferation (GO:0001833)3.02384267
76negative regulation of erythrocyte differentiation (GO:0045647)3.01481966
77mitotic chromosome condensation (GO:0007076)2.99848654
78nucleosome disassembly (GO:0006337)2.99713090
79protein-DNA complex disassembly (GO:0032986)2.99713090
80positive regulation of gene expression, epigenetic (GO:0045815)2.99299155
81regulation of viral release from host cell (GO:1902186)2.99260122
82mRNA stabilization (GO:0048255)2.98550707
83RNA stabilization (GO:0043489)2.98550707
84* termination of RNA polymerase II transcription (GO:0006369)2.98384843
85chromatin assembly (GO:0031497)2.96844060
86regulation of histone H3-K9 methylation (GO:0051570)2.96047081
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.94870958
88regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94576134
89mitotic sister chromatid cohesion (GO:0007064)2.93162313
90calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.92882336
91mitotic nuclear envelope disassembly (GO:0007077)2.92509876
92DNA replication initiation (GO:0006270)2.92230224
93ribosome biogenesis (GO:0042254)2.90549835
94negative regulation of gene expression, epigenetic (GO:0045814)2.90021521
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.87996870
96vesicle targeting (GO:0006903)2.87645461
97neutrophil activation involved in immune response (GO:0002283)2.85720361
98peptidyl-lysine dimethylation (GO:0018027)2.85484724
99ribosomal small subunit biogenesis (GO:0042274)2.85013655
100histone H4-K5 acetylation (GO:0043981)2.82812783
101histone H4-K8 acetylation (GO:0043982)2.82812783
102cell-cell junction maintenance (GO:0045217)2.81381226
103chromatin assembly or disassembly (GO:0006333)2.81159827
104ribonucleoprotein complex biogenesis (GO:0022613)2.80720651
105ATP-dependent chromatin remodeling (GO:0043044)2.79449067
106establishment of chromosome localization (GO:0051303)2.78805103
107nuclear pore complex assembly (GO:0051292)2.78294315
108DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.77597888
109DNA replication-dependent nucleosome assembly (GO:0006335)2.77595021
110DNA replication-dependent nucleosome organization (GO:0034723)2.77595021
111spliceosomal snRNP assembly (GO:0000387)2.77372483
112synaptonemal complex assembly (GO:0007130)2.76363118
113positive regulation of mitotic sister chromatid separation (GO:1901970)2.76256236
114positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76256236
115positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76256236
116translational elongation (GO:0006414)2.76239454
117regulation of chromosome segregation (GO:0051983)2.76049934
118regulation of histone H3-K27 methylation (GO:0061085)2.75784109
119nuclear pore organization (GO:0006999)2.75736462
120spliceosomal complex assembly (GO:0000245)2.75536417
121membrane disassembly (GO:0030397)2.74962635
122nuclear envelope disassembly (GO:0051081)2.74962635
123DNA topological change (GO:0006265)2.73102803
124cell migration in hindbrain (GO:0021535)2.72802727
125regulation of mRNA splicing, via spliceosome (GO:0048024)2.72399338
126positive regulation of synapse maturation (GO:0090129)2.72107131
127regulation of mRNA stability (GO:0043488)2.71531199
128regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71250480
129histone H4-K16 acetylation (GO:0043984)2.70843906
130regulation of exit from mitosis (GO:0007096)2.68308158
131negative regulation of fatty acid transport (GO:2000192)2.67272974
132DNA damage response, signal transduction resulting in transcription (GO:0042772)2.65486252
133regulation of RNA splicing (GO:0043484)2.63387401
134establishment of apical/basal cell polarity (GO:0035089)2.61981366
135negative regulation of histone modification (GO:0031057)2.61339337
136formation of translation preinitiation complex (GO:0001731)2.61296340
137DNA duplex unwinding (GO:0032508)2.61087033
138positive regulation of extracellular matrix organization (GO:1903055)2.60704877
139CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.60461425
140protein complex disassembly (GO:0043241)2.60197183
141histone H2A acetylation (GO:0043968)2.59235452
142ribosomal large subunit biogenesis (GO:0042273)2.58900980
143Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.58893193
144apoptotic process involved in morphogenesis (GO:0060561)2.58047063
145lung epithelium development (GO:0060428)2.58027688
146chromosome condensation (GO:0030261)2.56495685
147skin morphogenesis (GO:0043589)2.56026379
148regulation of apoptotic cell clearance (GO:2000425)2.55165659
149regulation of RNA stability (GO:0043487)2.55079209
150peptidyl-tyrosine autophosphorylation (GO:0038083)2.53473037
151regulation of stem cell maintenance (GO:2000036)2.52365629
152dorsal/ventral neural tube patterning (GO:0021904)2.51639928
153cochlea morphogenesis (GO:0090103)2.49404009
154cell-substrate adherens junction assembly (GO:0007045)2.49119804
155focal adhesion assembly (GO:0048041)2.49119804
156cerebral cortex neuron differentiation (GO:0021895)2.48221996
157proline biosynthetic process (GO:0006561)2.46909405
158regulation of chromatin binding (GO:0035561)2.46636924
159positive regulation of translation (GO:0045727)2.45223250
160establishment of protein localization to membrane (GO:0090150)2.40876042
161phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.40415002
162mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.40044774
163cerebellar Purkinje cell layer development (GO:0021680)2.37211362
164regulation of nucleobase-containing compound transport (GO:0032239)2.32610113
165DNA strand elongation involved in DNA replication (GO:0006271)2.32203338
166regulation of establishment of planar polarity (GO:0090175)2.29054243
167translation (GO:0006412)2.28759574
168cellular response to epidermal growth factor stimulus (GO:0071364)2.28639291
169regulation of extracellular matrix organization (GO:1903053)2.27872000
170proline metabolic process (GO:0006560)2.27593712
171DNA strand elongation (GO:0022616)2.27352905

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.04134666
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.07855683
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.43103368
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19772981
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95261841
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.84304132
7LXR_22292898_ChIP-Seq_THP-1_Human2.74514195
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.73393029
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.62278532
10MYC_22102868_ChIP-Seq_BL_Human2.61617894
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.61450763
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47490899
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26888221
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25119831
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09244453
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07772985
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.07396401
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.07396401
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.07396401
20* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07034370
21* XRN2_22483619_ChIP-Seq_HELA_Human2.05418954
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00027661
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.92206057
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90567292
25* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.87475104
26TET1_21451524_ChIP-Seq_MESCs_Mouse1.82726591
27ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81140557
28CIITA_25753668_ChIP-Seq_RAJI_Human1.78324604
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75926015
30SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.74167267
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73835103
32* ELK3_25401928_ChIP-Seq_HUVEC_Human1.73492413
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68588434
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68572803
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.68388309
36* E2F1_21310950_ChIP-Seq_MCF-7_Human1.67489615
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67479389
38KDM5A_27292631_Chip-Seq_BREAST_Human1.67285470
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66981396
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.66495114
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64285817
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63657057
43* RACK7_27058665_Chip-Seq_MCF-7_Human1.60332573
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60256778
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59878914
46MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.59392326
47* KDM2B_26808549_Chip-Seq_DND41_Human1.57488580
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57147325
49AR_21909140_ChIP-Seq_LNCAP_Human1.56445909
50TCF3_18692474_ChIP-Seq_MEFs_Mouse1.53316401
51POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52066620
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51021933
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50594048
54ZNF263_19887448_ChIP-Seq_K562_Human1.49174495
55VDR_21846776_ChIP-Seq_THP-1_Human1.48988863
56SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.48561840
57NANOG_21062744_ChIP-ChIP_HESCs_Human1.48079349
58TCF3_18692474_ChIP-Seq_MESCs_Mouse1.47976209
59TTF2_22483619_ChIP-Seq_HELA_Human1.45651037
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.45593582
61SMC4_20622854_ChIP-Seq_HELA_Human1.40841474
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40059915
63* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39110169
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37535005
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37498937
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.36918956
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36661413
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35884975
69VDR_24763502_ChIP-Seq_THP-1_Human1.34643321
70* CTCF_27219007_Chip-Seq_Bcells_Human1.34495303
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33151997
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.33064194
73SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32788194
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.30729837
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30683135
76* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30137357
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.29403106
78NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29039741
79NCOR1_26117541_ChIP-Seq_K562_Human1.25393604
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25007519
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.24775062
82STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.24428223
83KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24153131
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23610642
85NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23597705
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23061328
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21941717
88TCF7_22412390_ChIP-Seq_EML_Mouse1.21356165
89* MAF_26560356_Chip-Seq_TH2_Human1.20929767
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20677493
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20168727
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19885091
93KDM2B_26808549_Chip-Seq_JURKAT_Human1.18945534
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18053856
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17563241
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17095792
97CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16840382
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16043642
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15816096
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15010988
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14656120
102* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14515268
103* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14455003
104PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14055333
105* FOXP1_21924763_ChIP-Seq_HESCs_Human1.12998987
106CTCF_26484167_Chip-Seq_Bcells_Mouse1.11775101
107PHF8_20622854_ChIP-Seq_HELA_Human1.11066276
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10432905
109* CREB1_26743006_Chip-Seq_LNCaP_Human1.10426144
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09843714
111YY1_21170310_ChIP-Seq_MESCs_Mouse1.09840294
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09815255
113GABP_19822575_ChIP-Seq_HepG2_Human1.08397423
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.08120545
115KDM2B_26808549_Chip-Seq_K562_Human1.07752685
116P68_20966046_ChIP-Seq_HELA_Human1.07637235
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06972905
118CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06706773
119* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.06705464
120TP53_20018659_ChIP-ChIP_R1E_Mouse1.06509066
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06329393
122ESR2_21235772_ChIP-Seq_MCF-7_Human1.06192038
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05659508
124TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.04830148
125SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04797190
126* SA1_27219007_Chip-Seq_Bcells_Human1.04795209
127TP63_17297297_ChIP-ChIP_HaCaT_Human1.04734854
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04293571
129RARA_24833708_ChIP-Seq_LIVER_Mouse1.03426562
130POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03349738
131* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03205757
132MYC_18940864_ChIP-ChIP_HL60_Human1.03145447
133TP53_22127205_ChIP-Seq_IMR90_Human1.02793688
134RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02202107
135ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01859435
136* MAF_26560356_Chip-Seq_TH1_Human1.01482302
137* EST1_17652178_ChIP-ChIP_JURKAT_Human1.00458771
138E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.00152307
139SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00114761
140* CHD1_26751641_Chip-Seq_LNCaP_Human0.99428941
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99029566
142ETS1_21867929_ChIP-Seq_TH2_Mouse0.99017357
143E2F1_20622854_ChIP-Seq_HELA_Human0.98176971
144* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97839440
145CTCF_21964334_Chip-Seq_Bcells_Human0.96970070
146* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96582689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.35242993
2MP0000566_synostosis4.13014820
3MP0003693_abnormal_embryo_hatching3.78048837
4MP0003111_abnormal_nucleus_morphology3.70157604
5MP0002089_abnormal_postnatal_growth/wei3.68267472
6MP0004957_abnormal_blastocyst_morpholog3.24069698
7MP0003123_paternal_imprinting3.10462381
8MP0004858_abnormal_nervous_system3.07849959
9MP0002653_abnormal_ependyma_morphology2.77424785
10MP0008877_abnormal_DNA_methylation2.69638123
11MP0003077_abnormal_cell_cycle2.65256833
12MP0008057_abnormal_DNA_replication2.50616238
13MP0010094_abnormal_chromosome_stability2.49863436
14MP0003283_abnormal_digestive_organ2.41289912
15MP0006292_abnormal_olfactory_placode2.39339250
16MP0001730_embryonic_growth_arrest2.21170140
17MP0003119_abnormal_digestive_system2.18258582
18MP0001348_abnormal_lacrimal_gland2.10445501
19MP0002102_abnormal_ear_morphology2.06155488
20MP0002084_abnormal_developmental_patter2.02335617
21MP0003315_abnormal_perineum_morphology1.98037960
22MP0002085_abnormal_embryonic_tissue1.97543640
23MP0003890_abnormal_embryonic-extraembry1.91625538
24MP0000537_abnormal_urethra_morphology1.88171359
25MP0010030_abnormal_orbit_morphology1.86293069
26MP0000350_abnormal_cell_proliferation1.85811096
27MP0005360_urolithiasis1.82658415
28MP0001672_abnormal_embryogenesis/_devel1.81579510
29MP0005380_embryogenesis_phenotype1.81579510
30MP0003121_genomic_imprinting1.76108065
31MP0003329_amyloid_beta_deposits1.75518245
32MP0001346_abnormal_lacrimal_gland1.74928196
33MP0003787_abnormal_imprinting1.71275865
34MP0002249_abnormal_larynx_morphology1.70786917
35MP0003878_abnormal_ear_physiology1.68343845
36MP0005377_hearing/vestibular/ear_phenot1.68343845
37MP0008932_abnormal_embryonic_tissue1.65866111
38MP0001697_abnormal_embryo_size1.63340814
39MP0003861_abnormal_nervous_system1.55007827
40MP0005409_darkened_coat_color1.52840266
41MP0003937_abnormal_limbs/digits/tail_de1.52787395
42MP0008007_abnormal_cellular_replicative1.52141111
43MP0003984_embryonic_growth_retardation1.52052903
44MP0004197_abnormal_fetal_growth/weight/1.51137726
45MP0002088_abnormal_embryonic_growth/wei1.50969156
46MP0003938_abnormal_ear_development1.50810322
47MP0000678_abnormal_parathyroid_gland1.48921089
48MP0001849_ear_inflammation1.48328590
49MP0008058_abnormal_DNA_repair1.48146272
50MP0001915_intracranial_hemorrhage1.48141551
51MP0003136_yellow_coat_color1.46085145
52MP0009672_abnormal_birth_weight1.44160431
53MP0008995_early_reproductive_senescence1.41869224
54MP0002086_abnormal_extraembryonic_tissu1.41854701
55MP0002080_prenatal_lethality1.41450262
56MP0005076_abnormal_cell_differentiation1.40590670
57MP0009053_abnormal_anal_canal1.39140132
58MP0003385_abnormal_body_wall1.36808900
59MP0002210_abnormal_sex_determination1.34962705
60MP0000462_abnormal_digestive_system1.34845049
61MP0005666_abnormal_adipose_tissue1.34083878
62MP0004133_heterotaxia1.33021247
63MP0003115_abnormal_respiratory_system1.31375171
64MP0001727_abnormal_embryo_implantation1.30711972
65MP0001293_anophthalmia1.27645490
66MP0004185_abnormal_adipocyte_glucose1.26011229
67MP0000428_abnormal_craniofacial_morphol1.19879904
68MP0009703_decreased_birth_body1.19093488
69MP0001929_abnormal_gametogenesis1.19076860
70MP0001145_abnormal_male_reproductive1.18730915
71MP0004859_abnormal_synaptic_plasticity1.18443903
72MP0003935_abnormal_craniofacial_develop1.18222578
73MP0002697_abnormal_eye_size1.16939691
74MP0003122_maternal_imprinting1.16322368
75MP0000049_abnormal_middle_ear1.14985338
76MP0009278_abnormal_bone_marrow1.14409196
77MP0000432_abnormal_head_morphology1.14330454
78MP0010234_abnormal_vibrissa_follicle1.14173063
79MP0001188_hyperpigmentation1.13503141
80MP0003567_abnormal_fetal_cardiomyocyte1.10693535
81MP0000955_abnormal_spinal_cord1.08238164
82MP0000653_abnormal_sex_gland1.08060228
83MP0004264_abnormal_extraembryonic_tissu1.06186780
84MP0005423_abnormal_somatic_nervous1.05753995
85MP0003755_abnormal_palate_morphology1.05351916
86MP0003436_decreased_susceptibility_to1.01676877
87MP0000534_abnormal_ureter_morphology1.01400036
88MP0005187_abnormal_penis_morphology1.01163760
89MP0001299_abnormal_eye_distance/1.01007768
90MP0003718_maternal_effect1.00455957
91MP0001502_abnormal_circadian_rhythm0.98409063
92MP0000778_abnormal_nervous_system0.97492090
93MP0002114_abnormal_axial_skeleton0.97147562
94MP0002138_abnormal_hepatobiliary_system0.96714082
95MP0001485_abnormal_pinna_reflex0.96533791
96MP0005394_taste/olfaction_phenotype0.95751027
97MP0005499_abnormal_olfactory_system0.95751027
98MP0001286_abnormal_eye_development0.94981077
99MP0003698_abnormal_male_reproductive0.94960048
100MP0000631_abnormal_neuroendocrine_gland0.94844884
101MP0006072_abnormal_retinal_apoptosis0.94486267
102MP0002111_abnormal_tail_morphology0.94337291
103MP0008770_decreased_survivor_rate0.93518648
104MP0002932_abnormal_joint_morphology0.93454881
105MP0002116_abnormal_craniofacial_bone0.93019764
106MP0004885_abnormal_endolymph0.92225627
107MP0002152_abnormal_brain_morphology0.92148701
108MP0003942_abnormal_urinary_system0.91819790
109MP0009384_cardiac_valve_regurgitation0.90942511
110MP0002938_white_spotting0.90315400
111MP0010352_gastrointestinal_tract_polyps0.90042468
112MP0002254_reproductive_system_inflammat0.89454073
113MP0003705_abnormal_hypodermis_morpholog0.89069065
114MP0000313_abnormal_cell_death0.88592805
115MP0003635_abnormal_synaptic_transmissio0.87599025
116MP0002396_abnormal_hematopoietic_system0.86892502
117MP0002233_abnormal_nose_morphology0.84596457
118MP0005375_adipose_tissue_phenotype0.83974514
119MP0003879_abnormal_hair_cell0.83952753
120MP0002161_abnormal_fertility/fecundity0.83755495
121MP0002081_perinatal_lethality0.83574406
122MP0004145_abnormal_muscle_electrophysio0.83573887
123MP0002092_abnormal_eye_morphology0.82408452
124MP0008789_abnormal_olfactory_epithelium0.82148203
125MP0009250_abnormal_appendicular_skeleto0.80990296
126MP0002234_abnormal_pharynx_morphology0.79767163
127MP0003699_abnormal_female_reproductive0.79665168
128MP0001486_abnormal_startle_reflex0.79576237
129MP0005171_absent_coat_pigmentation0.78785526
130MP0002184_abnormal_innervation0.78573788
131MP0008569_lethality_at_weaning0.76541691
132MP0000750_abnormal_muscle_regeneration0.72799887
133MP0003303_peritoneal_inflammation0.72124720
134MP0003786_premature_aging0.72070656
135MP0005058_abnormal_lysosome_morphology0.71116086
136MP0000467_abnormal_esophagus_morphology0.70397049

Predicted human phenotypes

RankGene SetZ-score
1Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)7.25128848
2Agnosia (HP:0010524)6.04786515
3Progressive external ophthalmoplegia (HP:0000590)5.17973860
4Axonal loss (HP:0003447)4.38778889
5Disinhibition (HP:0000734)4.28934254
6Breast hypoplasia (HP:0003187)3.77718165
7Personality changes (HP:0000751)3.65581590
8Turricephaly (HP:0000262)3.56800750
9Patellar aplasia (HP:0006443)3.56037470
10Upper motor neuron abnormality (HP:0002127)3.55862493
11Aplasia/Hypoplasia of the patella (HP:0006498)3.43486477
12Choanal stenosis (HP:0000452)3.41548283
13Neurofibrillary tangles (HP:0002185)3.34222723
14Deep venous thrombosis (HP:0002625)3.30342236
15Facial hemangioma (HP:0000329)3.09525214
16Shawl scrotum (HP:0000049)3.07722935
17Ependymoma (HP:0002888)3.06692603
18Partial duplication of thumb phalanx (HP:0009944)3.04541359
19Multiple enchondromatosis (HP:0005701)3.02871946
20Birth length less than 3rd percentile (HP:0003561)3.02849901
21Partial duplication of the phalanx of hand (HP:0009999)2.88801247
22Abnormality of the labia minora (HP:0012880)2.84188930
23Oligodactyly (HP:0012165)2.83215296
24Rib fusion (HP:0000902)2.81751485
25Inappropriate behavior (HP:0000719)2.79177854
26Ulnar bowing (HP:0003031)2.78383233
27Supernumerary spleens (HP:0009799)2.66290699
28Coronal craniosynostosis (HP:0004440)2.65703443
29Cerebral inclusion bodies (HP:0100314)2.61737136
30Supernumerary ribs (HP:0005815)2.58979164
31Vaginal fistula (HP:0004320)2.58713291
32Obstructive sleep apnea (HP:0002870)2.57618422
33Aplasia involving forearm bones (HP:0009822)2.53522623
34Absent forearm bone (HP:0003953)2.53522623
35Absent radius (HP:0003974)2.52372409
36Abnormality of cells of the erythroid lineage (HP:0012130)2.49325130
37Supernumerary bones of the axial skeleton (HP:0009144)2.46719150
38External ophthalmoplegia (HP:0000544)2.44769996
39Abdominal situs inversus (HP:0003363)2.44074079
40Abnormality of abdominal situs (HP:0011620)2.44074079
41Intestinal fistula (HP:0100819)2.41478676
42Abnormality of cochlea (HP:0000375)2.39119979
43Abnormality of the fingertips (HP:0001211)2.37668611
44Broad palm (HP:0001169)2.37213314
45Pallor (HP:0000980)2.37036023
46Annular pancreas (HP:0001734)2.34056191
47Reticulocytopenia (HP:0001896)2.33811947
48Neoplasm of striated muscle (HP:0009728)2.32996874
49Male infertility (HP:0003251)2.32770320
50Basal cell carcinoma (HP:0002671)2.32148563
51Trismus (HP:0000211)2.31912860
52Rectovaginal fistula (HP:0000143)2.31287325
53Rectal fistula (HP:0100590)2.31287325
54Short phalanx of the thumb (HP:0009660)2.30097284
55Medulloblastoma (HP:0002885)2.29830330
56Hyperacusis (HP:0010780)2.29522220
57Anal stenosis (HP:0002025)2.28861917
58Abnormal number of incisors (HP:0011064)2.25433659
59Astrocytoma (HP:0009592)2.25047481
60Abnormality of the astrocytes (HP:0100707)2.25047481
61Bronchomalacia (HP:0002780)2.24792714
62Aplasia/hypoplasia of the humerus (HP:0006507)2.17976931
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17175321
64Atresia of the external auditory canal (HP:0000413)2.15084413
65Aplasia/Hypoplasia of the breasts (HP:0010311)2.14852302
66Abnormal number of erythroid precursors (HP:0012131)2.14834744
67Horseshoe kidney (HP:0000085)2.14196443
68Renal duplication (HP:0000075)2.14108212
69Nasolacrimal duct obstruction (HP:0000579)2.13962306
70Pseudobulbar signs (HP:0002200)2.13117267
71Morphological abnormality of the inner ear (HP:0011390)2.12740143
72High anterior hairline (HP:0009890)2.12281052
73Truncus arteriosus (HP:0001660)2.12135730
74Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12035177
75Concave nail (HP:0001598)2.10632146
76Myokymia (HP:0002411)2.10346224
77Colon cancer (HP:0003003)2.09145286
78Oligodactyly (hands) (HP:0001180)2.07092141
79Abnormality of the lacrimal duct (HP:0011481)2.04648627
80Esophageal atresia (HP:0002032)2.04436772
81Increased nuchal translucency (HP:0010880)2.03306430
82Abnormality of reticulocytes (HP:0004312)2.03228424
83Broad face (HP:0000283)2.02397101
84Aplasia involving bones of the upper limbs (HP:0009823)2.00806432
85Aplasia of the phalanges of the hand (HP:0009802)2.00806432
86Aplasia involving bones of the extremities (HP:0009825)2.00806432
87Overlapping toe (HP:0001845)2.00629971
88Skin tags (HP:0010609)2.00110750
89Short 4th metacarpal (HP:0010044)1.99964856
90Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99964856
91Abnormality of the lower motor neuron (HP:0002366)1.99489320
92Proximal placement of thumb (HP:0009623)1.99011322
93Thin ribs (HP:0000883)1.98799001
94Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98194821
95Sandal gap (HP:0001852)1.97567267
96Breast aplasia (HP:0100783)1.97545312
97Broad distal phalanx of finger (HP:0009836)1.96538003
98Short thumb (HP:0009778)1.95866581
99Genu recurvatum (HP:0002816)1.95397114
100Rhabdomyosarcoma (HP:0002859)1.94982097
101Acute lymphatic leukemia (HP:0006721)1.93860448
102Aplasia/Hypoplasia of the sternum (HP:0006714)1.93591089
103Metaphyseal cupping (HP:0003021)1.93528179
104Pointed chin (HP:0000307)1.93516097
105Selective tooth agenesis (HP:0001592)1.92387344
106Deep palmar crease (HP:0006191)1.91320512
107Hypoplasia of the radius (HP:0002984)1.91292079
108Chromsome breakage (HP:0040012)1.89763845
109Absent thumb (HP:0009777)1.89380314
110Abnormality of the 1st metacarpal (HP:0010009)1.89200397
111Spina bifida occulta (HP:0003298)1.88703843
112Tracheoesophageal fistula (HP:0002575)1.88686667
113Long eyelashes (HP:0000527)1.86622760
11411 pairs of ribs (HP:0000878)1.86251200
115Short humerus (HP:0005792)1.86170048
116Renovascular hypertension (HP:0100817)1.85767213
117Disproportionate tall stature (HP:0001519)1.84880014
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84862407
119Chin dimple (HP:0010751)1.84612205
120Oral leukoplakia (HP:0002745)1.83313801
121Macrocytic anemia (HP:0001972)1.83313615
122Septo-optic dysplasia (HP:0100842)1.82958904
123Duplication of thumb phalanx (HP:0009942)1.82293547
124Neoplasm of the oral cavity (HP:0100649)1.82291620
125Shallow orbits (HP:0000586)1.81880129
126Preauricular skin tag (HP:0000384)1.80419867
127Trigonocephaly (HP:0000243)1.80270134
128Heterotopia (HP:0002282)1.79975570
129Squamous cell carcinoma (HP:0002860)1.78706232
130Overriding aorta (HP:0002623)1.78667724
131Facial cleft (HP:0002006)1.78598698
132Glioma (HP:0009733)1.78083475
133Prominent nose (HP:0000448)1.77764132
134Meckel diverticulum (HP:0002245)1.77305291
135Limited elbow extension (HP:0001377)1.77075419
136Abnormality of the diencephalon (HP:0010662)1.76634821
137Carpal bone hypoplasia (HP:0001498)1.76418499
138Microtia (HP:0008551)1.76334738
139Abnormality of the aortic arch (HP:0012303)1.76128860
140Impulsivity (HP:0100710)1.75931393
141Broad thumb (HP:0011304)1.75793818
142Deviation of the thumb (HP:0009603)1.74952147
143Pathologic fracture (HP:0002756)1.74620069
144Cortical dysplasia (HP:0002539)1.74378501
145Long palpebral fissure (HP:0000637)1.74225495
146Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.72756116
147Abnormality of the distal phalanx of the thumb (HP:0009617)1.72747984
148Insomnia (HP:0100785)1.72194241
149Abnormality of the parietal bone (HP:0002696)1.72149777
150Achilles tendon contracture (HP:0001771)1.71834636
151Anal atresia (HP:0002023)1.71429061
152Neoplasm of the pancreas (HP:0002894)1.71359997
153Vertebral fusion (HP:0002948)1.71080986
154Anophthalmia (HP:0000528)1.70811827
155Cheekbone underdevelopment (HP:0010669)1.70344060
156Abnormality of the phalanges of the hallux (HP:0010057)1.69329688
157Abnormality of the middle phalanges of the toes (HP:0010183)1.68641705
158Abnormality of the ileum (HP:0001549)1.67379843
159Abnormality of the nasolacrimal system (HP:0000614)1.66739579
160Glossoptosis (HP:0000162)1.66239995
161Broad toe (HP:0001837)1.65958374
162Arnold-Chiari malformation (HP:0002308)1.64225059
163Broad phalanges of the hand (HP:0009768)1.63223694
164Biconcave vertebral bodies (HP:0004586)1.61709042
165Elfin facies (HP:0004428)1.60719010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.64426438
2CDC73.42315387
3LATS22.92936807
4PNCK2.91191527
5NEK22.82765941
6FGFR42.81367695
7EEF2K2.68239569
8SMG12.63058947
9LATS12.61138060
10SRPK12.37011675
11MAP3K102.32865625
12TYRO32.24514860
13MKNK22.17698613
14EIF2AK12.15416202
15WEE12.15324634
16BRD42.14753808
17ICK2.06576920
18TTK2.02192061
19PRPF4B2.00114864
20TAOK11.99047605
21SIK11.90651762
22TRIB31.90464707
23CDK71.85451911
24MAP3K61.81776730
25ALK1.66535385
26KSR21.65487366
27SCYL21.64833830
28MKNK11.57498962
29DYRK31.54950983
30MAP3K91.52618963
31BUB11.45172688
32MAPK151.42884676
33PKN21.41433011
34PLK11.41068773
35NME21.40550529
36FGFR21.39329394
37CDK41.34953387
38MAPK121.34056456
39CHEK11.30520045
40CHEK21.28839888
41TLK11.17883405
42FGFR11.16567676
43RPS6KB21.12697674
44AURKB1.12606837
45CDK91.10677101
46PRKD21.09817914
47PDGFRA1.09339746
48CDK21.09180791
49CSNK1E1.04896931
50PAK61.04107619
51MTOR1.02436619
52STK381.01475623
53CDK191.00821886
54NME11.00645877
55VRK20.99965763
56MAP2K60.99577330
57KSR10.98471013
58STK38L0.97124437
59CAMK1G0.96773907
60DYRK1A0.96436240
61BRSK20.95751482
62MAP3K10.95348686
63FGFR30.95060544
64SIK20.93035177
65MAP3K40.91641544
66NTRK10.91464117
67RIPK40.90479855
68ATR0.89566227
69DDR20.87546263
70MAP3K80.87372896
71PRKCI0.86856087
72ATM0.85531211
73PASK0.83471265
74TAOK20.82512118
75RET0.81847470
76DMPK0.81362354
77PRKD30.81264016
78EPHB20.80194994
79CDK10.75484778
80MARK20.75329713
81STK110.74565899
82PAK40.74218480
83CDK30.73783558
84PTK60.72959087
85BRSK10.71939005
86AURKA0.71295463
87CDK180.70415982
88NTRK20.70118378
89CDK60.69937051
90ERN10.69725351
91GRK60.69071901
92AKT20.68451799
93STK30.67752872
94LRRK20.66110919
95WNK40.64999216
96PDPK10.64624447
97MAP2K40.62658338
98CAMK1D0.62184888
99RAF10.61907586
100NTRK30.61222657
101UHMK10.60563720
102BMX0.60158644
103PLK30.59419962
104WNK10.59069928
105GSK3B0.58551127
106CDK140.57704772
107NEK10.57391281
108RPS6KL10.56962606
109RPS6KC10.56962606
110MAPK100.56911835
111SGK4940.55060172
112SGK2230.55060172
113PRKDC0.54941052
114MAP2K20.53860922
115CDK11A0.52981613
116RPS6KA20.52702640
117IRAK40.52282186
118PAK10.51144372
119CSNK1G10.50801319
120CSNK2A20.50558824
121DYRK1B0.50071623
122RPS6KA10.49640340
123MAP3K130.49291097
124PAK20.48183103
125MAPK140.47608072
126RPS6KA40.45548894
127CDK150.43618154
128RPS6KA60.43506707
129CSNK1D0.42759365
130ERBB20.42525025
131MAPKAPK50.41863829
132MAP4K10.41628368
133EPHA40.41109404
134PTK20.41046854
135PRKCZ0.40200681
136MAP3K110.40195923
137MAP2K30.39693344
138HIPK20.39177864
139IRAK30.38564914
140CAMKK10.38371419
141CSNK1G20.38240103
142RIPK10.37418807
143DYRK20.37097923
144MAPK110.35026938
145CSNK1A1L0.35000027
146CSNK1G30.34826654
147CDC42BPA0.34722641
148AKT10.33473833

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.51883532
2RNA transport_Homo sapiens_hsa030133.12248824
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07393294
4* mRNA surveillance pathway_Homo sapiens_hsa030152.99227821
5RNA polymerase_Homo sapiens_hsa030202.74274447
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71229798
7DNA replication_Homo sapiens_hsa030302.66385660
8Cell cycle_Homo sapiens_hsa041102.46506157
9Ribosome_Homo sapiens_hsa030102.41977288
10Mismatch repair_Homo sapiens_hsa034302.27787018
11Basal cell carcinoma_Homo sapiens_hsa052172.17150327
12Homologous recombination_Homo sapiens_hsa034402.00503996
13Linoleic acid metabolism_Homo sapiens_hsa005911.98856017
14Hedgehog signaling pathway_Homo sapiens_hsa043401.90328040
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.82095558
16Basal transcription factors_Homo sapiens_hsa030221.78282041
17Oocyte meiosis_Homo sapiens_hsa041141.77367446
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.71434714
19Sulfur relay system_Homo sapiens_hsa041221.68771095
20Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.65285350
21Fanconi anemia pathway_Homo sapiens_hsa034601.64058465
22RNA degradation_Homo sapiens_hsa030181.60211450
23Nucleotide excision repair_Homo sapiens_hsa034201.58448660
24Base excision repair_Homo sapiens_hsa034101.57787545
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55819104
26Hippo signaling pathway_Homo sapiens_hsa043901.54383369
27Lysine degradation_Homo sapiens_hsa003101.39532429
28MicroRNAs in cancer_Homo sapiens_hsa052061.32126172
29Notch signaling pathway_Homo sapiens_hsa043301.29771646
30Wnt signaling pathway_Homo sapiens_hsa043101.29413210
31One carbon pool by folate_Homo sapiens_hsa006701.24427936
32Thyroid cancer_Homo sapiens_hsa052161.23641862
33Ether lipid metabolism_Homo sapiens_hsa005651.22391820
34Other glycan degradation_Homo sapiens_hsa005111.20764956
35Pyrimidine metabolism_Homo sapiens_hsa002401.19449710
36Prion diseases_Homo sapiens_hsa050201.17993146
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16339907
38Bladder cancer_Homo sapiens_hsa052191.12921754
39mTOR signaling pathway_Homo sapiens_hsa041501.11526183
40TGF-beta signaling pathway_Homo sapiens_hsa043501.10237109
41p53 signaling pathway_Homo sapiens_hsa041151.05429065
42Endometrial cancer_Homo sapiens_hsa052131.03978425
43B cell receptor signaling pathway_Homo sapiens_hsa046621.01942921
44Melanogenesis_Homo sapiens_hsa049160.99162293
45Chronic myeloid leukemia_Homo sapiens_hsa052200.97124905
46Long-term potentiation_Homo sapiens_hsa047200.95694198
47Colorectal cancer_Homo sapiens_hsa052100.95033979
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.93856523
49Tight junction_Homo sapiens_hsa045300.93168177
50GnRH signaling pathway_Homo sapiens_hsa049120.93048050
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92528974
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.91800658
53Non-small cell lung cancer_Homo sapiens_hsa052230.91582337
54Nicotine addiction_Homo sapiens_hsa050330.91360309
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.90987333
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90850559
57Choline metabolism in cancer_Homo sapiens_hsa052310.88720715
58Dorso-ventral axis formation_Homo sapiens_hsa043200.88484633
59Glioma_Homo sapiens_hsa052140.87521164
60Adherens junction_Homo sapiens_hsa045200.85405659
61VEGF signaling pathway_Homo sapiens_hsa043700.84258903
62Small cell lung cancer_Homo sapiens_hsa052220.81422235
63Estrogen signaling pathway_Homo sapiens_hsa049150.81386239
64Long-term depression_Homo sapiens_hsa047300.79876650
65Renal cell carcinoma_Homo sapiens_hsa052110.79363431
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79325639
67HTLV-I infection_Homo sapiens_hsa051660.77882177
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77095451
69ErbB signaling pathway_Homo sapiens_hsa040120.75552398
70Glutamatergic synapse_Homo sapiens_hsa047240.75316563
71Vitamin digestion and absorption_Homo sapiens_hsa049770.75124781
72Axon guidance_Homo sapiens_hsa043600.71743595
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71318165
74Cardiac muscle contraction_Homo sapiens_hsa042600.70709291
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68606725
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67917562
77Prostate cancer_Homo sapiens_hsa052150.67133815
78Pathways in cancer_Homo sapiens_hsa052000.66915461
79Epstein-Barr virus infection_Homo sapiens_hsa051690.66318923
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.66095152
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.65476318
82Ras signaling pathway_Homo sapiens_hsa040140.65460361
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.65041076
84Gap junction_Homo sapiens_hsa045400.64802884
85Acute myeloid leukemia_Homo sapiens_hsa052210.64104714
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63050249
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62394136
88Amphetamine addiction_Homo sapiens_hsa050310.61923223
89Proteoglycans in cancer_Homo sapiens_hsa052050.61342281
90MAPK signaling pathway_Homo sapiens_hsa040100.59327652
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58924334
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58829594
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58268074
94Hepatitis C_Homo sapiens_hsa051600.57700037
95Vitamin B6 metabolism_Homo sapiens_hsa007500.56531818
96Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54925132
97Thyroid hormone synthesis_Homo sapiens_hsa049180.54346717
98Herpes simplex infection_Homo sapiens_hsa051680.53265665
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53082497
100Melanoma_Homo sapiens_hsa052180.51668108
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50962113
102Dopaminergic synapse_Homo sapiens_hsa047280.50587072
103HIF-1 signaling pathway_Homo sapiens_hsa040660.50275551
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50020341
105Biosynthesis of amino acids_Homo sapiens_hsa012300.49546159
106Bile secretion_Homo sapiens_hsa049760.49457067
107Cocaine addiction_Homo sapiens_hsa050300.48932807
108Oxytocin signaling pathway_Homo sapiens_hsa049210.48850366
109Pancreatic cancer_Homo sapiens_hsa052120.48553617
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48460489
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48366908
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46908069
113FoxO signaling pathway_Homo sapiens_hsa040680.46277303
114Purine metabolism_Homo sapiens_hsa002300.46133967
115Non-homologous end-joining_Homo sapiens_hsa034500.46065698
116Complement and coagulation cascades_Homo sapiens_hsa046100.45453803
117Rap1 signaling pathway_Homo sapiens_hsa040150.44744301
118Prolactin signaling pathway_Homo sapiens_hsa049170.44454244
119Cholinergic synapse_Homo sapiens_hsa047250.44203599
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43276033
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42878124
122AMPK signaling pathway_Homo sapiens_hsa041520.39428841
123Arachidonic acid metabolism_Homo sapiens_hsa005900.39163560
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39001768
125Fat digestion and absorption_Homo sapiens_hsa049750.38497676
126Viral carcinogenesis_Homo sapiens_hsa052030.38040276
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36441422
128Glucagon signaling pathway_Homo sapiens_hsa049220.35849747
129Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35216485
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.35089444
131Insulin signaling pathway_Homo sapiens_hsa049100.34424632
132Huntingtons disease_Homo sapiens_hsa050160.34405245
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33403225
134Arginine biosynthesis_Homo sapiens_hsa002200.33311783
135Circadian rhythm_Homo sapiens_hsa047100.31977065

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