PABPN1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein kinase C signaling (GO:0070528)8.67153778
2positive regulation of humoral immune response (GO:0002922)8.09774752
3regulation of DNA methylation (GO:0044030)8.02997374
4piRNA metabolic process (GO:0034587)7.77536541
5regulation of meiosis (GO:0040020)7.68672015
6female gamete generation (GO:0007292)7.66904032
7negative regulation of meiotic cell cycle (GO:0051447)7.60771637
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)7.24047942
9mitotic chromosome condensation (GO:0007076)7.07077982
10meiotic cell cycle (GO:0051321)6.64485646
11reproduction (GO:0000003)6.60116848
12regulation of histone H3-K9 methylation (GO:0051570)6.43961731
13protein K6-linked ubiquitination (GO:0085020)6.38566019
14positive regulation of histone H3-K4 methylation (GO:0051571)6.35245437
15negative regulation of meiosis (GO:0045835)6.34652370
16regulation of histone H3-K27 methylation (GO:0061085)6.09937232
17regulation of meiotic cell cycle (GO:0051445)6.08536088
18mitotic metaphase plate congression (GO:0007080)5.99283820
19retinal cone cell development (GO:0046549)5.92284674
20attachment of spindle microtubules to kinetochore (GO:0008608)5.84322780
21citrulline biosynthetic process (GO:0019240)5.55314735
22protein localization to kinetochore (GO:0034501)5.53163051
23glycine transport (GO:0015816)5.52297444
24base-excision repair, AP site formation (GO:0006285)5.49555703
25binding of sperm to zona pellucida (GO:0007339)5.47840593
26regulation of steroid hormone secretion (GO:2000831)5.24636027
27histone H2A monoubiquitination (GO:0035518)5.19430173
28histone H2A ubiquitination (GO:0033522)5.14970508
29pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.96694992
30metaphase plate congression (GO:0051310)4.94190435
31protein localization to chromosome, centromeric region (GO:0071459)4.90158344
32negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.85330675
33establishment of spindle localization (GO:0051293)4.78427708
34positive regulation of reproductive process (GO:2000243)4.69497654
35establishment of spindle orientation (GO:0051294)4.69180445
36single fertilization (GO:0007338)4.56020776
37fertilization (GO:0009566)4.51693319
38regulation of calcium ion-dependent exocytosis (GO:0017158)4.49872788
39negative regulation of DNA-templated transcription, elongation (GO:0032785)4.46451735
40negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.46451735
41notochord development (GO:0030903)4.41832084
42establishment of chromosome localization (GO:0051303)4.38304320
43DNA damage induced protein phosphorylation (GO:0006975)4.38147569
44chaperone-mediated protein transport (GO:0072321)4.33296198
45oocyte maturation (GO:0001556)4.33135243
46regulation of phospholipid biosynthetic process (GO:0071071)4.31863432
47DNA methylation involved in gamete generation (GO:0043046)4.30585579
48sperm-egg recognition (GO:0035036)4.26866658
49regulation of sister chromatid cohesion (GO:0007063)4.24641339
50maturation of 5.8S rRNA (GO:0000460)4.23924961
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.22435948
52protein localization to chromosome (GO:0034502)4.18264971
53regulation of cell maturation (GO:1903429)4.15464423
54regulation of histone H3-K4 methylation (GO:0051569)4.13607655
55pyrimidine nucleotide catabolic process (GO:0006244)4.07888635
56mitotic sister chromatid segregation (GO:0000070)4.05154461
57positive regulation of gastrulation (GO:2000543)4.01446156
58regulation of reproductive process (GO:2000241)4.01270266
59positive regulation of uterine smooth muscle contraction (GO:0070474)3.98882546
60chromatin assembly or disassembly (GO:0006333)3.97220646
61negative regulation of smooth muscle cell differentiation (GO:0051151)3.96336773
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.95242672
63positive regulation of histone methylation (GO:0031062)3.93813161
64CENP-A containing nucleosome assembly (GO:0034080)3.91854099
65phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.90296606
66male meiosis (GO:0007140)3.90064434
67regulation of exit from mitosis (GO:0007096)3.89990225
68male meiosis I (GO:0007141)3.85914685
69regulation of mitotic spindle organization (GO:0060236)3.84782255
70chromatin remodeling at centromere (GO:0031055)3.79631223
71L-amino acid import (GO:0043092)3.78507393
72regulation of acrosome reaction (GO:0060046)3.78070782
73negative regulation of histone methylation (GO:0031061)3.76367214
74regulation of steroid hormone biosynthetic process (GO:0090030)3.76094855
75positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.73245035
76regulation of histone methylation (GO:0031060)3.71377827
77regulation of spindle organization (GO:0090224)3.70291848
78negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.69881681
79microtubule severing (GO:0051013)3.69410931
80N-terminal protein amino acid acetylation (GO:0006474)3.67718983
81regulation of cytokine production involved in inflammatory response (GO:1900015)3.66650413
82multicellular organism reproduction (GO:0032504)3.65109650
83histone exchange (GO:0043486)3.64967184
84gene silencing by RNA (GO:0031047)3.64955491
85DNA replication-independent nucleosome assembly (GO:0006336)3.64681738
86DNA replication-independent nucleosome organization (GO:0034724)3.64681738
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.64051292
88folic acid-containing compound biosynthetic process (GO:0009396)3.64050484
89positive regulation of megakaryocyte differentiation (GO:0045654)3.61126103
90positive regulation of chromosome segregation (GO:0051984)3.61003480
91primitive streak formation (GO:0090009)3.60114394
92phosphorelay signal transduction system (GO:0000160)3.59357300
93DNA replication checkpoint (GO:0000076)3.58498929
94positive regulation of Cdc42 GTPase activity (GO:0043089)3.57416759
95negative regulation of reproductive process (GO:2000242)3.54707031
96chromosome segregation (GO:0007059)3.53398156
97chromatin assembly (GO:0031497)3.49639308
98meiotic chromosome segregation (GO:0045132)3.46793528
99cell-cell recognition (GO:0009988)3.45828659
100DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.42223224
101DNA damage response, signal transduction resulting in transcription (GO:0042772)3.38903982
102stress granule assembly (GO:0034063)3.38238883
103mitotic nuclear envelope disassembly (GO:0007077)3.37782687
104histone phosphorylation (GO:0016572)3.37176463
105spindle checkpoint (GO:0031577)3.36651335
106meiosis I (GO:0007127)3.33397712
107type B pancreatic cell development (GO:0003323)3.32207730
108gene silencing (GO:0016458)3.30478397
109negative regulation of histone modification (GO:0031057)3.29641950
110citrulline metabolic process (GO:0000052)3.29317569
111glycerophospholipid catabolic process (GO:0046475)3.29093647
112endothelium development (GO:0003158)3.28653387
113phosphatidylinositol dephosphorylation (GO:0046856)3.28194378
114regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.28125942
115regulation of RIG-I signaling pathway (GO:0039535)3.26654702
116membrane disassembly (GO:0030397)3.26583756
117nuclear envelope disassembly (GO:0051081)3.26583756
118regulation of chromatin binding (GO:0035561)3.23679045
119sister chromatid segregation (GO:0000819)3.23363667
120cellular response to pH (GO:0071467)3.21193322
121regulation of transforming growth factor beta2 production (GO:0032909)3.20928334
122synapsis (GO:0007129)3.20864002
123histone H3-K9 demethylation (GO:0033169)3.20709349
124regulation of hypersensitivity (GO:0002883)3.20022291
125oocyte development (GO:0048599)3.18829129
126ventricular cardiac muscle cell development (GO:0055015)3.18610991
127regulation of meiosis I (GO:0060631)3.16882604
128aggressive behavior (GO:0002118)3.14064349
129regulation of chromosome segregation (GO:0051983)3.13329533
130positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11862459
131positive regulation of mitotic sister chromatid separation (GO:1901970)3.11862459
132positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11862459
133regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.10906235
134one-carbon metabolic process (GO:0006730)3.10689517
135negative regulation of nuclear division (GO:0051784)3.09792566
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.07584319
137microtubule nucleation (GO:0007020)3.07375757
138mitotic spindle checkpoint (GO:0071174)3.06132261
139regulation of chromatin silencing (GO:0031935)3.04731868
140protein K48-linked ubiquitination (GO:0070936)3.02605161
141DNA replication-dependent nucleosome assembly (GO:0006335)3.02443923
142DNA replication-dependent nucleosome organization (GO:0034723)3.02443923
143DNA alkylation (GO:0006305)3.01951975
144DNA methylation (GO:0006306)3.01951975
145positive regulation of mitochondrial fission (GO:0090141)3.01210383
146phospholipid dephosphorylation (GO:0046839)3.01118507
147response to acidic pH (GO:0010447)3.00667332
148positive regulation of T cell apoptotic process (GO:0070234)2.98022105
149phosphatidylglycerol biosynthetic process (GO:0006655)2.96830495
150regulation of corticosteroid hormone secretion (GO:2000846)2.96483418
151negative regulation of hormone biosynthetic process (GO:0032353)2.96074415
152negative regulation of chromosome segregation (GO:0051985)2.95780394
153hyperosmotic salinity response (GO:0042538)2.95635748
154regulation of uterine smooth muscle contraction (GO:0070472)2.95616945
155sister chromatid cohesion (GO:0007062)2.95203555
156negative regulation of cell division (GO:0051782)2.94365534
157protein monoubiquitination (GO:0006513)2.93702284
158positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.93296966
159interkinetic nuclear migration (GO:0022027)2.93149297
160centriole replication (GO:0007099)2.91528615
161regulation of cell cycle G2/M phase transition (GO:1902749)2.91033993
162negative regulation of chromatin modification (GO:1903309)2.89944839
163negative regulation of execution phase of apoptosis (GO:1900118)2.88547032
164regulation of female gonad development (GO:2000194)11.7695290
165regulation of retinoic acid receptor signaling pathway (GO:0048385)10.6602919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.62463423
2FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.56023980
3AR_21909140_ChIP-Seq_LNCAP_Human3.85912875
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.68705065
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.65541148
6E2F7_22180533_ChIP-Seq_HELA_Human3.40622370
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.40554357
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.16697505
9STAT6_21828071_ChIP-Seq_BEAS2B_Human3.14560087
10NOTCH1_21737748_ChIP-Seq_TLL_Human3.07981989
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.07164408
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.07164408
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.07164408
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.98253888
15KAP1_22055183_ChIP-Seq_ESCs_Mouse2.85081393
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.84296609
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51742916
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.35640091
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.31408670
20MYC_18940864_ChIP-ChIP_HL60_Human2.29011387
21RUNX1_26923725_Chip-Seq_HPCs_Mouse2.28549694
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.27314704
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10789752
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07828884
25MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.02766512
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86830635
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79470040
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76979144
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76644046
30E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67753646
31ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.51902829
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.49458189
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.47801333
34NANOG_21062744_ChIP-ChIP_HESCs_Human1.46166817
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.44780376
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.44649382
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.43418852
38CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43148971
39LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38116277
40TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35148944
41CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33789309
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.31393783
43TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30546373
44SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.29187290
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27908872
46SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25503295
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.24662257
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24455208
49ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23167848
50RNF2_27304074_Chip-Seq_NSC_Mouse1.22565264
51ERG_20517297_ChIP-Seq_VCAP_Human1.17426948
52CDX2_22108803_ChIP-Seq_LS180_Human1.17081721
53SMRT_27268052_Chip-Seq_Bcells_Human1.14489863
54GATA3_21867929_ChIP-Seq_TH1_Mouse1.14377513
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13670145
56GF1B_26923725_Chip-Seq_HPCs_Mouse1.13106232
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12328716
58TBX5_21415370_ChIP-Seq_HL-1_Mouse1.11763774
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11693229
60NFYA_21822215_ChIP-Seq_K562_Human1.10866561
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09138434
62SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09044402
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08301728
64NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07648327
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06514859
66KLF4_19829295_ChIP-Seq_ESCs_Human1.05623791
67OCT4_19829295_ChIP-Seq_ESCs_Human1.04858691
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03147374
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02696509
70NANOG_20526341_ChIP-Seq_ESCs_Human1.02641612
71EWS_26573619_Chip-Seq_HEK293_Human1.01921771
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00956154
73STAT3_23295773_ChIP-Seq_U87_Human1.00403990
74P68_20966046_ChIP-Seq_HELA_Human1.00340432
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.99776004
76PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99621261
77* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98722792
78MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98676570
79* VDR_21846776_ChIP-Seq_THP-1_Human0.97947162
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97805245
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97293434
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.97084272
83BCOR_27268052_Chip-Seq_Bcells_Human0.96109837
84OCT1_27270436_Chip-Seq_PROSTATE_Human0.96069654
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95961035
86BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.92149991
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92014385
88STAT1_17558387_ChIP-Seq_HELA_Human0.91136501
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90947334
90CTCF_21964334_Chip-Seq_Bcells_Human0.89661873
91GATA3_26560356_Chip-Seq_TH1_Human0.89583597
92FOXO3_23340844_ChIP-Seq_DLD1_Human0.89107259
93BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88227662
94P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88220723
95ESR1_20079471_ChIP-ChIP_T-47D_Human0.88111336
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87871966
97CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87273941
98SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87250443
99* TP63_23658742_ChIP-Seq_EP156T_Human0.85361363
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.85230845
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84744372
102KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82857098
103VDR_22108803_ChIP-Seq_LS180_Human0.82303240
104FUS_26573619_Chip-Seq_HEK293_Human0.82235324
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81718819
106MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81696534
107EZH2_22144423_ChIP-Seq_EOC_Human0.81224030
108CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80403789
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80260584
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.79971854
111PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.79730458
112HNFA_21074721_ChIP-Seq_CACO-2_Human0.79574462
113PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79422273
114ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.79303191
115ETV1_20927104_ChIP-Seq_GIST48_Human0.79265644
116STAT1_20625510_ChIP-Seq_HELA_Human0.79182662
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78457012
118PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78350410
119GF1_26923725_Chip-Seq_HPCs_Mouse0.78269328
120FOXP3_21729870_ChIP-Seq_TREG_Human0.77735567
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76864986
122ATF3_27146783_Chip-Seq_COLON_Human0.76180355
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.76111854
124GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75508481
125NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75353547
126TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75306640
127EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75175138
128EP300_21415370_ChIP-Seq_HL-1_Mouse0.75138529
129CTCF_20526341_ChIP-Seq_ESCs_Human0.74917418
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.74821608
131VDR_24763502_ChIP-Seq_THP-1_Human0.73611534
132ZNF274_21170338_ChIP-Seq_K562_Hela0.72788579
133TP53_22573176_ChIP-Seq_HFKS_Human0.72197557
134PHF8_20622854_ChIP-Seq_HELA_Human0.71747059
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71100542
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71100542
137BCL6_27268052_Chip-Seq_Bcells_Human0.70814771
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.70514992
139CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70474773
140GBX2_23144817_ChIP-Seq_PC3_Human0.69720008
141POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.69211640
142YY1_21170310_ChIP-Seq_MESCs_Mouse0.67366739
143SOX2_21211035_ChIP-Seq_LN229_Human0.66690678
144E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.64371552
145KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.64332988
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.62825822
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.62619886
148DROSHA_22980978_ChIP-Seq_HELA_Human0.61096109
149E2F1_17053090_ChIP-ChIP_MCF-7_Human0.60973825
150E2F1_20622854_ChIP-Seq_HELA_Human0.60421920
151TAF2_19829295_ChIP-Seq_ESCs_Human0.60100827
152RAC3_21632823_ChIP-Seq_H3396_Human0.59685475
153CBP_20019798_ChIP-Seq_JUKART_Human0.59088745
154IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.59088745
155TCF4_23295773_ChIP-Seq_U87_Human0.58874009
156THAP11_20581084_ChIP-Seq_MESCs_Mouse0.58186504
157OCT4_20526341_ChIP-Seq_ESCs_Human0.58032718
158KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.57379590
159GATA3_21878914_ChIP-Seq_MCF-7_Human0.56864251
160CBP_21632823_ChIP-Seq_H3396_Human0.56550323
161RUNX2_22187159_ChIP-Seq_PCA_Human0.55641874
162REST_21632747_ChIP-Seq_MESCs_Mouse0.54590437
163ESR1_15608294_ChIP-ChIP_MCF-7_Human0.53624440
164CTCF_26484167_Chip-Seq_Bcells_Mouse0.53008701
165CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.51218293
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.50747502
167IRF1_19129219_ChIP-ChIP_H3396_Human0.49913270
168AR_25329375_ChIP-Seq_VCAP_Human0.49906248
169NCOR_22424771_ChIP-Seq_293T_Human0.49772206
170CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.48896682
171MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.48797026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect7.42809701
2MP0005451_abnormal_body_composition6.54467036
3MP0003646_muscle_fatigue5.25361119
4MP0002653_abnormal_ependyma_morphology4.77149633
5MP0008789_abnormal_olfactory_epithelium3.49120998
6MP0005394_taste/olfaction_phenotype3.33890151
7MP0005499_abnormal_olfactory_system3.33890151
8MP0005395_other_phenotype3.30759682
9MP0003699_abnormal_female_reproductive3.22401846
10MP0001119_abnormal_female_reproductive3.20485810
11MP0003693_abnormal_embryo_hatching3.18711208
12MP0008057_abnormal_DNA_replication3.16935419
13MP0010094_abnormal_chromosome_stability3.16800063
14MP0003111_abnormal_nucleus_morphology2.94895957
15MP0001986_abnormal_taste_sensitivity2.92047344
16MP0008877_abnormal_DNA_methylation2.78965064
17MP0003077_abnormal_cell_cycle2.76293528
18MP0002102_abnormal_ear_morphology2.51768886
19MP0002138_abnormal_hepatobiliary_system2.51550619
20MP0001929_abnormal_gametogenesis2.38420106
21MP0000653_abnormal_sex_gland2.31573526
22MP0003879_abnormal_hair_cell2.31163883
23MP0004957_abnormal_blastocyst_morpholog2.14075388
24MP0008260_abnormal_autophagy2.11532161
25MP0002210_abnormal_sex_determination1.99255906
26MP0001915_intracranial_hemorrhage1.96211432
27MP0005408_hypopigmentation1.94844414
28MP0010030_abnormal_orbit_morphology1.90768751
29MP0008058_abnormal_DNA_repair1.89361162
30MP0006292_abnormal_olfactory_placode1.84689001
31MP0004264_abnormal_extraembryonic_tissu1.75584150
32MP0005410_abnormal_fertilization1.75393535
33MP0010307_abnormal_tumor_latency1.70074358
34MP0001529_abnormal_vocalization1.68812140
35MP0002161_abnormal_fertility/fecundity1.67869053
36MP0003183_abnormal_peptide_metabolism1.66817574
37MP0002295_abnormal_pulmonary_circulatio1.66372070
38MP0003136_yellow_coat_color1.64673183
39MP0000579_abnormal_nail_morphology1.62152303
40MP0001905_abnormal_dopamine_level1.59042132
41MP0005423_abnormal_somatic_nervous1.57384716
42MP0002234_abnormal_pharynx_morphology1.56371417
43MP0006072_abnormal_retinal_apoptosis1.55291520
44MP0005310_abnormal_salivary_gland1.53207158
45MP0009379_abnormal_foot_pigmentation1.52054670
46MP0008932_abnormal_embryonic_tissue1.51531193
47MP0010234_abnormal_vibrissa_follicle1.51113519
48MP0002160_abnormal_reproductive_system1.48543786
49MP0004510_myositis1.48284137
50MP0004185_abnormal_adipocyte_glucose1.43736390
51MP0003937_abnormal_limbs/digits/tail_de1.43140981
52MP0004859_abnormal_synaptic_plasticity1.37523274
53MP0009840_abnormal_foam_cell1.36120510
54MP0003950_abnormal_plasma_membrane1.33523526
55MP0003705_abnormal_hypodermis_morpholog1.31761084
56MP0005174_abnormal_tail_pigmentation1.28922163
57MP0000350_abnormal_cell_proliferation1.28190825
58MP0006276_abnormal_autonomic_nervous1.19855296
59MP0010368_abnormal_lymphatic_system1.19609975
60MP0000015_abnormal_ear_pigmentation1.18906061
61MP0000566_synostosis1.16417183
62MP0001145_abnormal_male_reproductive1.15655940
63MP0005409_darkened_coat_color1.15272545
64MP0000639_abnormal_adrenal_gland1.11398054
65MP0002019_abnormal_tumor_incidence1.09644978
66MP0003252_abnormal_bile_duct1.08498222
67MP0002085_abnormal_embryonic_tissue1.08391932
68MP0004142_abnormal_muscle_tone1.07276402
69MP0001664_abnormal_digestion1.04976322
70MP0001293_anophthalmia1.03546587
71MP0003453_abnormal_keratinocyte_physiol1.03186572
72MP0002932_abnormal_joint_morphology1.02887072
73MP0001849_ear_inflammation1.01247016
74MP0001730_embryonic_growth_arrest1.00433059
75MP0002249_abnormal_larynx_morphology0.99827803
76MP0010386_abnormal_urinary_bladder0.97395569
77MP0004381_abnormal_hair_follicle0.94672003
78MP0001697_abnormal_embryo_size0.93469973
79MP0000490_abnormal_crypts_of0.91420496
80MP0003890_abnormal_embryonic-extraembry0.90330742
81MP0001346_abnormal_lacrimal_gland0.90309267
82MP0000427_abnormal_hair_cycle0.88911513
83MP0003763_abnormal_thymus_physiology0.88296308
84MP0009384_cardiac_valve_regurgitation0.85666378
85MP0002084_abnormal_developmental_patter0.84495032
86MP0001485_abnormal_pinna_reflex0.82571576
87MP0000465_gastrointestinal_hemorrhage0.82045841
88MP0003121_genomic_imprinting0.80482505
89MP0003315_abnormal_perineum_morphology0.79683516
90MP0001919_abnormal_reproductive_system0.79612355
91MP0005360_urolithiasis0.78129306
92MP0000762_abnormal_tongue_morphology0.77261974
93MP0001324_abnormal_eye_pigmentation0.77211495
94MP0005085_abnormal_gallbladder_physiolo0.76519655
95MP0005646_abnormal_pituitary_gland0.76067438
96MP0003119_abnormal_digestive_system0.75765296
97MP0005621_abnormal_cell_physiology0.75480584
98MP0002233_abnormal_nose_morphology0.75247298
99MP0005257_abnormal_intraocular_pressure0.74594965
100MP0005501_abnormal_skin_physiology0.74340952
101MP0002127_abnormal_cardiovascular_syste0.73624205
102MP0002177_abnormal_outer_ear0.73305498
103MP0000631_abnormal_neuroendocrine_gland0.72055920
104MP0002272_abnormal_nervous_system0.72028652
105MP0001672_abnormal_embryogenesis/_devel0.71831297
106MP0005380_embryogenesis_phenotype0.71831297
107MP0005076_abnormal_cell_differentiation0.71461203
108MP0005197_abnormal_uvea_morphology0.70575263
109MP0008007_abnormal_cellular_replicative0.70447227
110MP0001666_abnormal_nutrient_absorption0.69898413
111MP0003123_paternal_imprinting0.69385288
112MP0005551_abnormal_eye_electrophysiolog0.68591215
113MP0001545_abnormal_hematopoietic_system0.65667287
114MP0005397_hematopoietic_system_phenotyp0.65667287
115MP0001502_abnormal_circadian_rhythm0.64860499
116MP0005187_abnormal_penis_morphology0.63914688
117MP0002796_impaired_skin_barrier0.60906047
118MP0002735_abnormal_chemical_nociception0.59543223
119MP0002877_abnormal_melanocyte_morpholog0.59456775
120MP0002928_abnormal_bile_duct0.57895085
121MP0005023_abnormal_wound_healing0.56296110
122MP0003698_abnormal_male_reproductive0.56078917
123MP0003959_abnormal_lean_body0.55716235
124MP0000733_abnormal_muscle_development0.55425710
125MP0005647_abnormal_sex_gland0.54349606
126MP0003984_embryonic_growth_retardation0.53547278
127MP0003787_abnormal_imprinting0.53144051
128MP0005389_reproductive_system_phenotype0.52843977
129MP0004484_altered_response_of0.52390045
130MP0000678_abnormal_parathyroid_gland0.51759134
131MP0005075_abnormal_melanosome_morpholog0.51128864
132MP0003755_abnormal_palate_morphology0.50735797
133MP0002080_prenatal_lethality0.50428347
134MP0002089_abnormal_postnatal_growth/wei0.50128944
135MP0001944_abnormal_pancreas_morphology0.49101760
136MP0002088_abnormal_embryonic_growth/wei0.48801931
137MP0010678_abnormal_skin_adnexa0.48463098
138MP0002269_muscular_atrophy0.48204938
139MP0004782_abnormal_surfactant_physiolog0.47371309
140MP0005384_cellular_phenotype0.47156386
141MP0000313_abnormal_cell_death0.46929416
142MP0005319_abnormal_enzyme/_coenzyme0.45538504
143MP0002873_normal_phenotype0.45534178
144MP0002169_no_abnormal_phenotype0.45174911
145MP0005379_endocrine/exocrine_gland_phen0.44830323
146MP0008995_early_reproductive_senescence0.44830026
147MP0002139_abnormal_hepatobiliary_system0.44463404
148MP0002095_abnormal_skin_pigmentation0.44324723
149MP0001881_abnormal_mammary_gland0.44263792
150MP0002168_other_aberrant_phenotype0.43345284
151MP0001963_abnormal_hearing_physiology0.42593197
152MP0003632_abnormal_nervous_system0.42213149
153MP0004043_abnormal_pH_regulation0.42187794
154MP0001851_eye_inflammation0.42143629
155MP0004145_abnormal_muscle_electrophysio0.41677269
156MP0003861_abnormal_nervous_system0.41039471
157MP0000462_abnormal_digestive_system0.40136432

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.19256784
2Cholecystitis (HP:0001082)5.55340188
3Abnormal gallbladder physiology (HP:0012438)5.55340188
4Premature ovarian failure (HP:0008209)5.40852439
5Birth length less than 3rd percentile (HP:0003561)5.35844934
6Impulsivity (HP:0100710)5.24619090
7Infertility (HP:0000789)4.97461301
8Breast hypoplasia (HP:0003187)4.84377395
9Lip pit (HP:0100267)4.80959420
10Hypophosphatemic rickets (HP:0004912)4.78407170
11Abnormality of abdominal situs (HP:0011620)4.73118870
12Abdominal situs inversus (HP:0003363)4.73118870
13Osteomalacia (HP:0002749)4.69329271
14Secondary amenorrhea (HP:0000869)4.01777287
15Supernumerary spleens (HP:0009799)4.01509010
16Cortical dysplasia (HP:0002539)3.90150398
17Aplasia/Hypoplasia of the sternum (HP:0006714)3.76213889
18Rhabdomyosarcoma (HP:0002859)3.66194982
19Papillary thyroid carcinoma (HP:0002895)3.63414497
20Aplasia/Hypoplasia of the macula (HP:0008059)3.58727896
21Aplasia of the musculature (HP:0100854)3.58646815
22Chromsome breakage (HP:0040012)3.55993872
23Septo-optic dysplasia (HP:0100842)3.55211444
24Apathy (HP:0000741)3.51141243
25Adrenal hypoplasia (HP:0000835)3.50301703
26Azoospermia (HP:0000027)3.39098292
27Patellar aplasia (HP:0006443)3.32594558
28Diminished motivation (HP:0000745)3.32053043
29Aplasia/Hypoplasia affecting the retina (HP:0008061)3.28648814
30Arterial tortuosity (HP:0005116)3.19871803
31Hypokinesia (HP:0002375)3.15546541
32Flat capital femoral epiphysis (HP:0003370)3.15504355
33Shawl scrotum (HP:0000049)3.13552887
34Abnormality of the labia minora (HP:0012880)3.13470823
35Hypergonadotropic hypogonadism (HP:0000815)3.11057604
36Aplasia/Hypoplasia of the patella (HP:0006498)3.05584667
37Combined immunodeficiency (HP:0005387)3.05062621
38Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03411956
39Abnormality of alanine metabolism (HP:0010916)3.01715104
40Hyperalaninemia (HP:0003348)3.01715104
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.01715104
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.98922347
43Muscle stiffness (HP:0003552)2.92086901
44Absent septum pellucidum (HP:0001331)2.91141228
45Truncal obesity (HP:0001956)2.79782156
46Oligodactyly (hands) (HP:0001180)2.79339687
47Breast aplasia (HP:0100783)2.78961732
48Pulmonary fibrosis (HP:0002206)2.77812515
49Aplasia/Hypoplasia of the breasts (HP:0010311)2.77167754
50Loss of speech (HP:0002371)2.76530874
51Overlapping toe (HP:0001845)2.75259283
52Vascular tortuosity (HP:0004948)2.74024536
53Myokymia (HP:0002411)2.73800065
54Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.72811886
55Neoplasm of striated muscle (HP:0009728)2.69633470
56Abnormality of chromosome segregation (HP:0002916)2.65358200
57Metaphyseal irregularity (HP:0003025)2.61990194
58Gonadotropin excess (HP:0000837)2.60952250
59Median cleft lip (HP:0000161)2.60380073
60Chronic bronchitis (HP:0004469)2.57771046
61Abnormality of the septum pellucidum (HP:0007375)2.53751057
62Skin pits (HP:0100276)2.53035069
63Abnormality of the proximal phalanges of the hand (HP:0009834)2.51032797
64Hypercortisolism (HP:0001578)2.50732644
65Abnormality of lateral ventricle (HP:0030047)2.50048779
66Abnormal spermatogenesis (HP:0008669)2.49585557
67Short 1st metacarpal (HP:0010034)2.48451126
68Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.48451126
69Poikiloderma (HP:0001029)2.45843355
70Insulin-resistant diabetes mellitus (HP:0000831)2.43105837
71Spondylolisthesis (HP:0003302)2.41844072
72Sandal gap (HP:0001852)2.40095827
73Rib fusion (HP:0000902)2.37777672
74Urethral obstruction (HP:0000796)2.35719058
75Fetal akinesia sequence (HP:0001989)2.35287501
76Abnormality of the fingertips (HP:0001211)2.34629838
77Lower limb hyperreflexia (HP:0002395)2.34594940
78Abnormality of placental membranes (HP:0011409)2.28766886
79Amniotic constriction ring (HP:0009775)2.28766886
80Fibular aplasia (HP:0002990)2.27964474
81Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27893803
82Spinal cord compression (HP:0002176)2.26101963
83Anhidrosis (HP:0000970)2.24868861
84Short tibia (HP:0005736)2.24471560
85Abnormality of the anterior chamber (HP:0000593)2.23124202
86Abnormality of cochlea (HP:0000375)2.22963217
87Duodenal stenosis (HP:0100867)2.22697995
88Small intestinal stenosis (HP:0012848)2.22697995
89Increased circulating renin level (HP:0000848)2.20926940
90Attenuation of retinal blood vessels (HP:0007843)2.19591436
91Congenital sensorineural hearing impairment (HP:0008527)2.16565545
92Capillary hemangiomas (HP:0005306)2.16043000
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.14466252
94Primary amenorrhea (HP:0000786)2.13462660
95Abnormal sex determination (HP:0012244)2.13309045
96Sex reversal (HP:0012245)2.13309045
97Decreased circulating renin level (HP:0003351)2.12349918
98Hypoplastic iliac wings (HP:0002866)2.11875030
99Abnormality of the 1st metacarpal (HP:0010009)2.10804593
100Absent hand (HP:0004050)2.10418791
101Abnormality of the intervertebral disk (HP:0005108)2.09468081
102Facial hemangioma (HP:0000329)2.08997072
103Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.08172175
104Oligodactyly (HP:0012165)2.07917868
105Sensory axonal neuropathy (HP:0003390)2.07872442
106Uterine leiomyosarcoma (HP:0002891)2.07062387
107Leiomyosarcoma (HP:0100243)2.07062387
108Abnormality of the fovea (HP:0000493)2.04617847
109Carpal bone hypoplasia (HP:0001498)2.04258014
110Anomalous pulmonary venous return (HP:0010772)2.03994264
111Hypoplasia of the fovea (HP:0007750)2.03841616
112Aplasia/Hypoplasia of the fovea (HP:0008060)2.03841616
113Conjunctival telangiectasia (HP:0000524)2.03823509
114Supranuclear gaze palsy (HP:0000605)2.02804741
115Diastasis recti (HP:0001540)2.00412279
116Short phalanx of the thumb (HP:0009660)2.00172549
117Male infertility (HP:0003251)10.1692723
118Dysdiadochokinesis (HP:0002075)1.98741892
119Intrahepatic cholestasis (HP:0001406)1.98162960
120Chin dimple (HP:0010751)1.98152690
121Abnormality of chromosome stability (HP:0003220)1.97310089
122Posterior embryotoxon (HP:0000627)1.95471432
123Nephroblastoma (Wilms tumor) (HP:0002667)1.94562155
124Rickets (HP:0002748)1.93401606
125Generalized aminoaciduria (HP:0002909)1.93127977
126Anterior segment dysgenesis (HP:0007700)1.91985228
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.90845089
128Absent thumb (HP:0009777)1.90678707
129Acute myeloid leukemia (HP:0004808)1.89819643
130Bundle branch block (HP:0011710)1.89628333
131Preauricular pit (HP:0004467)1.88296024
132Periauricular skin pits (HP:0100277)1.88296024
133Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88107683
134Bile duct proliferation (HP:0001408)1.86475176
135Abnormal biliary tract physiology (HP:0012439)1.86475176
136Abnormal lung lobation (HP:0002101)1.86467345
137Atelectasis (HP:0100750)1.86237722
138Bony spicule pigmentary retinopathy (HP:0007737)1.86041312
139Cerebral hypomyelination (HP:0006808)1.85601665
140Ectopic kidney (HP:0000086)1.83666733
141Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82673894
142Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81388837
143Cleft eyelid (HP:0000625)1.80684151
144Myelodysplasia (HP:0002863)1.80458057
145Cone-rod dystrophy (HP:0000548)1.80432570
146Sloping forehead (HP:0000340)1.80008907
147Diminished movement (HP:0002374)1.79392309
148Abnormality of the line of Schwalbe (HP:0008048)1.79211393
149Embryonal renal neoplasm (HP:0011794)1.77972676
150Testicular atrophy (HP:0000029)1.77501244
151Absent radius (HP:0003974)1.77061561
152Abnormality of the phalanges of the hallux (HP:0010057)1.76956784
153Maternal diabetes (HP:0009800)1.75965362
154Short thumb (HP:0009778)1.75452697
155Subcapsular cataract (HP:0000523)1.75258553
156Transitional cell carcinoma of the bladder (HP:0006740)1.73946177
157Aplasia involving bones of the extremities (HP:0009825)1.73924619
158Aplasia involving bones of the upper limbs (HP:0009823)1.73924619
159Aplasia of the phalanges of the hand (HP:0009802)1.73924619
160Oral leukoplakia (HP:0002745)1.73901760
161Aplastic anemia (HP:0001915)1.73829253
162Malnutrition (HP:0004395)1.73295250
163Thyroid carcinoma (HP:0002890)1.72057484
164Striae distensae (HP:0001065)1.72014550
165Abnormality of the duodenum (HP:0002246)1.71572945
166Absent forearm bone (HP:0003953)1.71007586
167Aplasia involving forearm bones (HP:0009822)1.71007586
168Posterior subcapsular cataract (HP:0007787)1.69196977
169Abnormality of calcium-phosphate metabolism (HP:0100530)1.68309649
170Popliteal pterygium (HP:0009756)1.68095186
171Elevated alkaline phosphatase (HP:0003155)1.66751987
172Cranial hyperostosis (HP:0004437)1.65221113
173Non-midline cleft lip (HP:0100335)1.63870309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR27.20402587
2MOS7.03005556
3TAOK35.07134957
4LATS14.19513017
5CDK123.99495012
6MAP3K63.43090811
7LATS23.40266059
8NEK63.29590417
9STK38L2.74626095
10KSR22.67738798
11TTK2.66482423
12MAP3K92.60887735
13MAP3K132.26033393
14PLK42.25826612
15CDK82.05391172
16ARAF2.02016935
17TRIM281.96784110
18STK101.81306882
19MET1.76824559
20CDC71.69215924
21TAOK11.63556137
22ERBB41.61215194
23BRSK11.60048895
24TESK21.59880646
25BRAF1.56468633
26NTRK21.56431794
27DYRK21.53545799
28RAF11.45540469
29WNK11.44010548
30TNK21.40903065
31CDK91.29628139
32PRKD31.28501097
33BUB11.26195787
34MELK1.25738375
35MARK31.14103188
36STK31.12434474
37EEF2K1.08237757
38NLK1.07659372
39PIM11.07278075
40CDK191.03053005
41ERN11.01130774
42ZAK1.00354045
43CSNK1G10.99417008
44CAMK1D0.97389331
45MAP3K40.96923904
46PAK60.96322134
47MUSK0.95206859
48KSR10.92838295
49PLK10.92469716
50STK380.91997107
51NEK20.91938237
52MTOR0.91910357
53TNIK0.91549302
54PTK20.91365638
55RET0.89166223
56MAP3K80.87659178
57CHEK20.85798336
58TLK10.79228095
59CSNK1G30.76145223
60MAPK130.73967103
61PINK10.73267085
62ABL20.70052674
63CSNK1G20.69804656
64MAPKAPK30.67589450
65HIPK20.66569694
66TGFBR10.65785213
67EIF2AK30.65784491
68SRPK10.63201011
69CSNK1A1L0.62236930
70PRKD20.61900879
71BRD40.59686049
72MAP2K70.58663229
73PKN10.57614027
74MAPK150.57070775
75NTRK30.55116469
76BRSK20.53987268
77TYRO30.53898336
78AURKA0.50272243
79PDK10.49802623
80PRKCZ0.48903826
81WNK40.46532205
82AURKB0.45719434
83DMPK0.44027618
84ZAP700.43964716
85PDPK10.43505373
86CSNK1E0.42792081
87PRKG10.42427557
88TRIB30.40969185
89PRKAA10.39719776
90CDK50.38472500
91NEK10.37743333
92MAPKAPK50.37739708
93CAMK1G0.37616730
94TIE10.34683352
95GSK3B0.34283308
96MAP2K40.34199462
97ACVR1B0.32492585
98AKT20.32447095
99CDC42BPA0.32438468
100LRRK20.29513890
101MAPK100.29479248
102CDK40.29235771
103STK390.28751764
104PKN20.27844908
105TAOK20.27311648
106MAP3K10.27170637
107KIT0.26338583
108NUAK10.25752379
109IRAK20.25719398
110SGK20.24835291
111MAP3K70.24833542
112CDK70.24655469
113CLK10.23895094
114SGK4940.23686195
115SGK2230.23686195
116PRKAA20.23097132
117CAMK10.21916431
118CHUK0.21822886
119PRKACA0.20741503
120MAP3K50.20501084
121ABL10.20319667
122MAP2K10.19218958
123MST40.19046586
124MARK20.18637837
125MAPK110.17501573
126STK240.17462486
127ATM0.16611379
128CSNK1D0.16090320
129CAMK2A0.15154093
130PLK30.14736761
131CDK10.13204104
132PLK20.12051375
133PAK10.10075205
134CDK20.09424215
135EPHA30.09291096
136JAK20.08668398
137EIF2AK10.08304205
138CHEK10.08281757
139EPHA40.07441001
140ROCK20.03696037
141MAPK10.03570753
142ROCK10.03564636
143SGK30.03311406
144PRKCI0.02367505
145AKT10.02169527
146CSNK1A10.01911139
147MAP3K20.00505848
148SGK10.00084262
149STK11-0.0038308
150BMPR1B-0.0023112
151ATR-0.0009491

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049135.23316267
2Cell cycle_Homo sapiens_hsa041103.87366692
3RNA degradation_Homo sapiens_hsa030183.80428644
4Basal transcription factors_Homo sapiens_hsa030223.64379553
5Oocyte meiosis_Homo sapiens_hsa041143.45174726
6Circadian rhythm_Homo sapiens_hsa047103.39610057
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.81444481
8Vitamin B6 metabolism_Homo sapiens_hsa007502.76121407
9Pancreatic cancer_Homo sapiens_hsa052122.24683927
10Caffeine metabolism_Homo sapiens_hsa002322.21762320
11Folate biosynthesis_Homo sapiens_hsa007902.14518403
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.09677007
13Linoleic acid metabolism_Homo sapiens_hsa005912.04970603
14Base excision repair_Homo sapiens_hsa034102.04246328
15Ether lipid metabolism_Homo sapiens_hsa005651.90066026
16Dorso-ventral axis formation_Homo sapiens_hsa043201.80781344
17DNA replication_Homo sapiens_hsa030301.70673967
18TGF-beta signaling pathway_Homo sapiens_hsa043501.64979146
19Inositol phosphate metabolism_Homo sapiens_hsa005621.62670812
20GnRH signaling pathway_Homo sapiens_hsa049121.62535270
21Fanconi anemia pathway_Homo sapiens_hsa034601.61807146
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.60186760
23Non-homologous end-joining_Homo sapiens_hsa034501.60073391
24MicroRNAs in cancer_Homo sapiens_hsa052061.59306458
25Homologous recombination_Homo sapiens_hsa034401.41756614
26RNA polymerase_Homo sapiens_hsa030201.40628040
27RNA transport_Homo sapiens_hsa030131.38268644
28p53 signaling pathway_Homo sapiens_hsa041151.38104731
29Taste transduction_Homo sapiens_hsa047421.33008536
30Prolactin signaling pathway_Homo sapiens_hsa049171.31191498
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28632843
32Colorectal cancer_Homo sapiens_hsa052101.26834198
33Nucleotide excision repair_Homo sapiens_hsa034201.23203862
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22846873
35ABC transporters_Homo sapiens_hsa020101.21825136
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19961908
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09907165
38Notch signaling pathway_Homo sapiens_hsa043301.09487811
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08277684
40Choline metabolism in cancer_Homo sapiens_hsa052311.08065429
41Thyroid cancer_Homo sapiens_hsa052161.06418226
42Phototransduction_Homo sapiens_hsa047441.03227566
43Long-term depression_Homo sapiens_hsa047301.01092890
44mTOR signaling pathway_Homo sapiens_hsa041501.00603353
45VEGF signaling pathway_Homo sapiens_hsa043700.99627893
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93430512
47Glycosaminoglycan degradation_Homo sapiens_hsa005310.88304137
48Hippo signaling pathway_Homo sapiens_hsa043900.86949621
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.84617446
50Morphine addiction_Homo sapiens_hsa050320.81203317
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80838092
52Herpes simplex infection_Homo sapiens_hsa051680.80537325
53Nicotine addiction_Homo sapiens_hsa050330.79712668
54Renal cell carcinoma_Homo sapiens_hsa052110.79415095
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79190813
56Adherens junction_Homo sapiens_hsa045200.77091228
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76699956
58Bladder cancer_Homo sapiens_hsa052190.75475658
59FoxO signaling pathway_Homo sapiens_hsa040680.73612464
60Viral carcinogenesis_Homo sapiens_hsa052030.71311183
61GABAergic synapse_Homo sapiens_hsa047270.70696711
62Bile secretion_Homo sapiens_hsa049760.70406940
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70119866
64Ras signaling pathway_Homo sapiens_hsa040140.69752690
65Chronic myeloid leukemia_Homo sapiens_hsa052200.68689524
66MAPK signaling pathway_Homo sapiens_hsa040100.67727616
67Endometrial cancer_Homo sapiens_hsa052130.66639907
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66129315
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61816943
70Regulation of autophagy_Homo sapiens_hsa041400.59567441
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59232272
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.57810808
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57169592
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56608386
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55622948
76Sulfur relay system_Homo sapiens_hsa041220.55445901
77HTLV-I infection_Homo sapiens_hsa051660.54322428
78* mRNA surveillance pathway_Homo sapiens_hsa030150.52819222
79Non-small cell lung cancer_Homo sapiens_hsa052230.52695109
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51573899
81Estrogen signaling pathway_Homo sapiens_hsa049150.51082818
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50757845
83Pyrimidine metabolism_Homo sapiens_hsa002400.50100472
84Small cell lung cancer_Homo sapiens_hsa052220.47256288
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46427124
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45667495
87Mismatch repair_Homo sapiens_hsa034300.45653247
88Wnt signaling pathway_Homo sapiens_hsa043100.44597776
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43643990
90Glioma_Homo sapiens_hsa052140.41863130
91Shigellosis_Homo sapiens_hsa051310.39760379
92Purine metabolism_Homo sapiens_hsa002300.39164484
93Glutamatergic synapse_Homo sapiens_hsa047240.38709659
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38113663
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37074449
96Vitamin digestion and absorption_Homo sapiens_hsa049770.34737423
97Gap junction_Homo sapiens_hsa045400.34711755
98ErbB signaling pathway_Homo sapiens_hsa040120.34525953
99Acute myeloid leukemia_Homo sapiens_hsa052210.33275023
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33118810
101Serotonergic synapse_Homo sapiens_hsa047260.32067017
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.31601317
103Synaptic vesicle cycle_Homo sapiens_hsa047210.31171267
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30919514
105B cell receptor signaling pathway_Homo sapiens_hsa046620.30394976
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27678197
107Complement and coagulation cascades_Homo sapiens_hsa046100.27428893
108Melanoma_Homo sapiens_hsa052180.27132556
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27045260
110Prostate cancer_Homo sapiens_hsa052150.26934727
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.26443033
112Hepatitis B_Homo sapiens_hsa051610.26332517
113Chemokine signaling pathway_Homo sapiens_hsa040620.26302752
114Spliceosome_Homo sapiens_hsa030400.26246724
115Phagosome_Homo sapiens_hsa041450.25711267
116Cholinergic synapse_Homo sapiens_hsa047250.25584254
117Hedgehog signaling pathway_Homo sapiens_hsa043400.25069652
118Arachidonic acid metabolism_Homo sapiens_hsa005900.24348945
119Long-term potentiation_Homo sapiens_hsa047200.24224505
120Other glycan degradation_Homo sapiens_hsa005110.22925123
121Tight junction_Homo sapiens_hsa045300.22151340
122Epstein-Barr virus infection_Homo sapiens_hsa051690.21657054
123Sphingolipid metabolism_Homo sapiens_hsa006000.21420191
124Oxytocin signaling pathway_Homo sapiens_hsa049210.21264969
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21237377
126cAMP signaling pathway_Homo sapiens_hsa040240.21157799
127Insulin signaling pathway_Homo sapiens_hsa049100.20429189
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.20254322
129Olfactory transduction_Homo sapiens_hsa047400.19180928
130Melanogenesis_Homo sapiens_hsa049160.19019995
131Calcium signaling pathway_Homo sapiens_hsa040200.18853796
132Pathways in cancer_Homo sapiens_hsa052000.17859585
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17595440
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.16867904
135Lysine degradation_Homo sapiens_hsa003100.16635238
136Huntingtons disease_Homo sapiens_hsa050160.15475922
137Glucagon signaling pathway_Homo sapiens_hsa049220.15036330

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