PACRG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.77702690
2axonemal dynein complex assembly (GO:0070286)9.66606191
3sperm motility (GO:0030317)9.56224007
4epithelial cilium movement (GO:0003351)9.21420714
5acrosome reaction (GO:0007340)8.86930223
6cilium movement (GO:0003341)8.78093444
7fusion of sperm to egg plasma membrane (GO:0007342)8.60535231
8regulation of cilium movement (GO:0003352)7.81185328
9motile cilium assembly (GO:0044458)7.66648460
10cell wall macromolecule catabolic process (GO:0016998)7.65248330
11cell wall macromolecule metabolic process (GO:0044036)7.65248330
12acrosome assembly (GO:0001675)7.51579775
13sperm-egg recognition (GO:0035036)7.50992647
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.48828632
15multicellular organism reproduction (GO:0032504)7.43121019
16binding of sperm to zona pellucida (GO:0007339)6.77127565
17* spermatid development (GO:0007286)6.72777354
18plasma membrane fusion (GO:0045026)6.70992653
19cell-cell recognition (GO:0009988)6.63022026
20piRNA metabolic process (GO:0034587)6.22234311
21reproduction (GO:0000003)6.11683878
22negative regulation of inclusion body assembly (GO:0090084)5.87792722
23ventricular system development (GO:0021591)5.81216429
24male meiosis (GO:0007140)5.65912536
25single fertilization (GO:0007338)5.51482400
26sperm capacitation (GO:0048240)5.47109664
27synaptonemal complex organization (GO:0070193)5.19369630
28protein localization to cilium (GO:0061512)5.16508635
29regulation of inclusion body assembly (GO:0090083)5.11687600
30axoneme assembly (GO:0035082)5.07322838
31regulation of microtubule-based movement (GO:0060632)5.05703932
32calcium ion-dependent exocytosis (GO:0017156)5.04921061
33synaptonemal complex assembly (GO:0007130)4.65571930
34intraciliary transport (GO:0042073)4.60099188
35fertilization (GO:0009566)4.59262718
36spermatogenesis (GO:0007283)4.58047342
37male gamete generation (GO:0048232)4.55623657
38left/right pattern formation (GO:0060972)4.27924416
39microtubule severing (GO:0051013)4.26408342
40gamete generation (GO:0007276)4.22277680
41organic cation transport (GO:0015695)4.06742016
42protein polyglutamylation (GO:0018095)3.91404814
43male meiosis I (GO:0007141)3.86863881
44cell recognition (GO:0008037)3.85288903
45cilium morphogenesis (GO:0060271)3.84575015
46DNA methylation involved in gamete generation (GO:0043046)3.84089393
47cilium organization (GO:0044782)3.80863439
48cilium assembly (GO:0042384)3.72129895
49centriole assembly (GO:0098534)3.72126807
50* germ cell development (GO:0007281)3.71804999
51microtubule depolymerization (GO:0007019)3.69193032
52* cellular process involved in reproduction in multicellular organism (GO:0022412)3.68705233
53nucleoside diphosphate phosphorylation (GO:0006165)3.61374602
54vitamin transmembrane transport (GO:0035461)3.53001581
55GTP biosynthetic process (GO:0006183)3.46675320
56microtubule-based movement (GO:0007018)3.38187581
57multicellular organismal reproductive process (GO:0048609)3.33652655
58spermatid nucleus differentiation (GO:0007289)3.32463872
59primary alcohol catabolic process (GO:0034310)3.30106634
60cellular component assembly involved in morphogenesis (GO:0010927)3.24761656
61one-carbon compound transport (GO:0019755)3.19579511
62negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19295767
63lactate metabolic process (GO:0006089)3.14555820
64retinal rod cell development (GO:0046548)3.12493755
65determination of left/right symmetry (GO:0007368)3.11398972
66ethanol metabolic process (GO:0006067)3.05649353
67membrane depolarization during action potential (GO:0086010)2.94986519
68sensory perception of smell (GO:0007608)2.94857492
69centriole replication (GO:0007099)2.94664705
70determination of bilateral symmetry (GO:0009855)2.94495171
71left/right axis specification (GO:0070986)2.93893978
72meiotic nuclear division (GO:0007126)2.92305811
73chromosome organization involved in meiosis (GO:0070192)2.89705393
74regulation of protein kinase A signaling (GO:0010738)2.89375318
75meiosis I (GO:0007127)2.89185773
76specification of symmetry (GO:0009799)2.86296607
77cellular ketone body metabolic process (GO:0046950)2.85507913
78UTP biosynthetic process (GO:0006228)2.85398296
79diterpenoid biosynthetic process (GO:0016102)2.85090386
80neuron cell-cell adhesion (GO:0007158)2.84584979
81glutathione derivative metabolic process (GO:1901685)2.83979759
82glutathione derivative biosynthetic process (GO:1901687)2.83979759
83pyrimidine-containing compound transmembrane transport (GO:0072531)2.81659793
84protein refolding (GO:0042026)2.80749958
85cytoplasmic microtubule organization (GO:0031122)2.78947811
86cornea development in camera-type eye (GO:0061303)2.76912466
87glycerol ether metabolic process (GO:0006662)2.76502632
88exogenous drug catabolic process (GO:0042738)2.76252407
89retinal cone cell development (GO:0046549)2.75606704
90ATP hydrolysis coupled proton transport (GO:0015991)2.73279583
91energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.73279583
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73071574
93negative regulation of T cell differentiation in thymus (GO:0033085)2.72525173
94response to acidic pH (GO:0010447)2.71414376
95glomerular epithelial cell development (GO:0072310)2.70797324
96response to xenobiotic stimulus (GO:0009410)2.67952676
97microtubule bundle formation (GO:0001578)2.67567799
98seminiferous tubule development (GO:0072520)2.65745667
99calcium ion import (GO:0070509)2.64516697
100detection of calcium ion (GO:0005513)2.63234900
101auditory behavior (GO:0031223)2.61076208
102ether metabolic process (GO:0018904)2.60572564
103multicellular organismal development (GO:0007275)2.59800344
104UTP metabolic process (GO:0046051)2.58936528
105polyol catabolic process (GO:0046174)2.54552983
106lung epithelium development (GO:0060428)2.53656948
107brain morphogenesis (GO:0048854)2.53433166
108ethanol oxidation (GO:0006069)2.52945704
109ketone body metabolic process (GO:1902224)2.52029566
110guanosine-containing compound biosynthetic process (GO:1901070)2.51723251
111behavioral response to nicotine (GO:0035095)2.48724390
112retinoic acid metabolic process (GO:0042573)2.47514619
113meiotic cell cycle (GO:0051321)2.47358888
114microtubule polymerization or depolymerization (GO:0031109)2.45652917
115spinal cord motor neuron differentiation (GO:0021522)2.45197238
116neurotransmitter metabolic process (GO:0042133)2.44361716
117synaptic vesicle exocytosis (GO:0016079)2.43259381
118limb development (GO:0060173)2.43069465
119appendage development (GO:0048736)2.43069465
120transmission of nerve impulse (GO:0019226)2.41998688
121gamma-aminobutyric acid transport (GO:0015812)2.40534293
122genitalia morphogenesis (GO:0035112)2.37857332
123neurotransmitter catabolic process (GO:0042135)2.37484685
124cell projection assembly (GO:0030031)2.36720852
125lateral ventricle development (GO:0021670)2.35934727
126behavioral response to ethanol (GO:0048149)2.34881826
127protein localization to synapse (GO:0035418)2.33906319
128negative regulation of organelle assembly (GO:1902116)2.33819304
129negative regulation of B cell mediated immunity (GO:0002713)2.32649013
130negative regulation of immunoglobulin mediated immune response (GO:0002890)2.32649013
131neuronal action potential (GO:0019228)2.32282860
132negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.29683464
133negative regulation of humoral immune response (GO:0002921)2.28325959
134carnitine metabolic process (GO:0009437)2.27744160
135nonmotile primary cilium assembly (GO:0035058)2.26411565
136regulation of short-term neuronal synaptic plasticity (GO:0048172)2.26229294
137retinol metabolic process (GO:0042572)2.25738464
138regulation of collateral sprouting (GO:0048670)2.25605782
139regulation of interleukin-5 production (GO:0032674)2.25402690
140regulation of autophagic vacuole assembly (GO:2000785)2.25233571
141response to pheromone (GO:0019236)2.24967431
142chaperone-mediated protein complex assembly (GO:0051131)2.23898925
143organelle assembly (GO:0070925)2.22924398
144drug catabolic process (GO:0042737)2.22919347
145neurotransmitter biosynthetic process (GO:0042136)2.22731424
146mitochondrial fission (GO:0000266)2.21637243
147glycolytic process (GO:0006096)2.20312009
148sensory perception of chemical stimulus (GO:0007606)2.19945490
149establishment of planar polarity (GO:0001736)2.19781349
150establishment of tissue polarity (GO:0007164)2.19781349
151neuronal action potential propagation (GO:0019227)2.19737648
152smoothened signaling pathway (GO:0007224)2.18674152
153photoreceptor cell differentiation (GO:0046530)2.17805142
154eye photoreceptor cell differentiation (GO:0001754)2.17805142
155presynaptic membrane assembly (GO:0097105)2.17275270
156terpenoid biosynthetic process (GO:0016114)2.17019895
157cellular response to pH (GO:0071467)2.16820578
158mechanosensory behavior (GO:0007638)2.15661419
159photoreceptor cell maintenance (GO:0045494)2.14778041
160photoreceptor cell development (GO:0042461)2.13159133
161presynaptic membrane organization (GO:0097090)2.12927355
162microtubule-based process (GO:0007017)2.12130077
163detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.11609229
164ubiquinone biosynthetic process (GO:0006744)2.10945895
165regulation of neurotransmitter uptake (GO:0051580)2.10908438
166pyrimidine nucleobase catabolic process (GO:0006208)2.10855596

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09338234
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.64299364
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.96828925
4VDR_22108803_ChIP-Seq_LS180_Human2.35728613
5GBX2_23144817_ChIP-Seq_PC3_Human2.29345445
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29096617
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.25800927
8REST_21632747_ChIP-Seq_MESCs_Mouse2.21026485
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17495849
10CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93447760
11TAF15_26573619_Chip-Seq_HEK293_Human1.89816460
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88464762
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86996013
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.78727894
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73925059
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69235559
17NR3C1_21868756_ChIP-Seq_MCF10A_Human1.68745118
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67227970
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65523934
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63069623
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60563655
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.58664914
23IGF1R_20145208_ChIP-Seq_DFB_Human1.57354462
24RNF2_27304074_Chip-Seq_NSC_Mouse1.57263252
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.56978314
26ZNF274_21170338_ChIP-Seq_K562_Hela1.53151438
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52051210
28GATA1_26923725_Chip-Seq_HPCs_Mouse1.49708615
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.49641027
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49418281
31SMAD4_21799915_ChIP-Seq_A2780_Human1.48993309
32MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48116335
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47675557
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46674984
35AR_21572438_ChIP-Seq_LNCaP_Human1.45366331
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44288092
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42978139
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42194737
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.36246445
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.36082403
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36043913
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36043913
43TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.34136831
44EWS_26573619_Chip-Seq_HEK293_Human1.33539015
45TAL1_26923725_Chip-Seq_HPCs_Mouse1.32551557
46CBP_20019798_ChIP-Seq_JUKART_Human1.32474758
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32474758
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31816684
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31694799
50TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31500459
51DROSHA_22980978_ChIP-Seq_HELA_Human1.30986157
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29295682
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.28882387
54ELK4_26923725_Chip-Seq_MESODERM_Mouse1.28683640
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27938850
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.27409404
57KDM2B_26808549_Chip-Seq_REH_Human1.27254709
58* TCF4_22108803_ChIP-Seq_LS180_Human1.26971736
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.23839316
60* P300_19829295_ChIP-Seq_ESCs_Human1.23286629
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23028346
62RUNX2_22187159_ChIP-Seq_PCA_Human1.22657865
63JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22376758
64ARNT_22903824_ChIP-Seq_MCF-7_Human1.20869669
65* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19575791
66SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19312324
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.18946674
68ER_23166858_ChIP-Seq_MCF-7_Human1.18873435
69SOX2_19829295_ChIP-Seq_ESCs_Human1.18065751
70NANOG_19829295_ChIP-Seq_ESCs_Human1.18065751
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15278829
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14494286
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14404301
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.14104047
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14104047
76WDR5_24793694_ChIP-Seq_LNCAP_Human1.14046725
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14040082
78* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13284321
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12996779
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11910519
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11387066
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10930126
83P53_22387025_ChIP-Seq_ESCs_Mouse1.09965520
84TP53_18474530_ChIP-ChIP_U2OS_Human1.09666904
85* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09269603
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08850097
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.08769466
88PHF8_20622853_ChIP-Seq_HELA_Human1.08489494
89* TCF4_23295773_ChIP-Seq_U87_Human1.08441310
90RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08196261
91TBL1_22424771_ChIP-Seq_293T_Human1.06700419
92CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06383885
93* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05676620
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.05531665
95SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05327059
96IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05309737
97* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05156036
98SMAD3_21741376_ChIP-Seq_ESCs_Human1.04879834
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04349492
100CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04125000
101AHR_22903824_ChIP-Seq_MCF-7_Human1.04080700
102BCAT_22108803_ChIP-Seq_LS180_Human1.03825531
103ETV1_20927104_ChIP-Seq_GIST48_Human1.03247578
104FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02604353
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.02489650
106CMYC_18555785_Chip-Seq_ESCs_Mouse1.02144974
107AR_25329375_ChIP-Seq_VCAP_Human1.01918636
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01521694
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01307477
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01192768
111STAT1_17558387_ChIP-Seq_HELA_Human1.00356701
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00298999
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00233137
114* FUS_26573619_Chip-Seq_HEK293_Human1.00159899
115* STAT3_23295773_ChIP-Seq_U87_Human0.99840660
116NCOR_22424771_ChIP-Seq_293T_Human0.99618847
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99337372
118NFYA_21822215_ChIP-Seq_K562_Human0.98913304
119NFYB_21822215_ChIP-Seq_K562_Human0.97850454
120GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.97829772
121EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97072779
122RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97072779
123PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96892595
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96063133
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95860135
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.95746746
127CDX2_22108803_ChIP-Seq_LS180_Human0.95630931
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95370050
129E2F1_18555785_Chip-Seq_ESCs_Mouse0.95233558
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.94796468
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.94626079
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94374504
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.93522505
134EED_16625203_ChIP-ChIP_MESCs_Mouse0.93278595
135* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93278325

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.57396967
2MP0003698_abnormal_male_reproductive3.71763468
3MP0001984_abnormal_olfaction3.63166224
4MP0008875_abnormal_xenobiotic_pharmacok3.21818899
5MP0001929_abnormal_gametogenesis3.11492160
6MP0002653_abnormal_ependyma_morphology2.98871569
7MP0004133_heterotaxia2.72326645
8MP0009046_muscle_twitch2.59595404
9MP0008877_abnormal_DNA_methylation2.58897508
10MP0004859_abnormal_synaptic_plasticity2.39742858
11MP0004270_analgesia2.35707397
12MP0005646_abnormal_pituitary_gland2.21839803
13MP0003635_abnormal_synaptic_transmissio2.20777218
14MP0003880_abnormal_central_pattern2.20266328
15MP0008789_abnormal_olfactory_epithelium2.04684186
16MP0005645_abnormal_hypothalamus_physiol1.99385220
17MP0009745_abnormal_behavioral_response1.96957009
18MP0002277_abnormal_respiratory_mucosa1.96903474
19MP0002161_abnormal_fertility/fecundity1.95915720
20MP0002272_abnormal_nervous_system1.94378273
21MP0005551_abnormal_eye_electrophysiolog1.93842879
22MP0002210_abnormal_sex_determination1.93796740
23MP0002064_seizures1.90724431
24MP0002132_abnormal_respiratory_system1.89607381
25MP0001986_abnormal_taste_sensitivity1.88288917
26MP0002734_abnormal_mechanical_nocicepti1.86740676
27MP0002572_abnormal_emotion/affect_behav1.86356054
28MP0005423_abnormal_somatic_nervous1.85128192
29MP0001486_abnormal_startle_reflex1.80379774
30MP0002063_abnormal_learning/memory/cond1.80339776
31MP0000566_synostosis1.72460248
32MP0001968_abnormal_touch/_nociception1.70259455
33MP0002736_abnormal_nociception_after1.61951914
34MP0001145_abnormal_male_reproductive1.59383962
35MP0001440_abnormal_grooming_behavior1.48485939
36MP0006276_abnormal_autonomic_nervous1.48092454
37MP0000013_abnormal_adipose_tissue1.46287037
38MP0000653_abnormal_sex_gland1.41538098
39MP0002735_abnormal_chemical_nociception1.39435550
40MP0004019_abnormal_vitamin_homeostasis1.37990772
41MP0003195_calcinosis1.36347889
42MP0002102_abnormal_ear_morphology1.35908685
43MP0002557_abnormal_social/conspecific_i1.35014564
44MP0002067_abnormal_sensory_capabilities1.34721710
45MP0006072_abnormal_retinal_apoptosis1.33950515
46MP0003329_amyloid_beta_deposits1.33585340
47MP0001501_abnormal_sleep_pattern1.33043829
48MP0005253_abnormal_eye_physiology1.31954237
49MP0003646_muscle_fatigue1.31655414
50MP0005084_abnormal_gallbladder_morpholo1.29395787
51MP0002160_abnormal_reproductive_system1.28957063
52MP0005623_abnormal_meninges_morphology1.26815696
53MP0002733_abnormal_thermal_nociception1.24690307
54MP0002909_abnormal_adrenal_gland1.23194490
55MP0004742_abnormal_vestibular_system1.21631010
56MP0001529_abnormal_vocalization1.20767901
57MP0001970_abnormal_pain_threshold1.20532663
58MP0000778_abnormal_nervous_system1.18724362
59MP0008872_abnormal_physiological_respon1.16967430
60MP0001502_abnormal_circadian_rhythm1.16314778
61MP0002882_abnormal_neuron_morphology1.16299645
62MP0003011_delayed_dark_adaptation1.14407773
63MP0002184_abnormal_innervation1.12697218
64MP0003634_abnormal_glial_cell1.12538145
65MP0002822_catalepsy1.10529054
66MP0002229_neurodegeneration1.07768838
67MP0008569_lethality_at_weaning1.07454280
68MP0000955_abnormal_spinal_cord1.06696295
69MP0000383_abnormal_hair_follicle1.05623701
70MP0004811_abnormal_neuron_physiology1.05289343
71MP0003879_abnormal_hair_cell1.04796001
72MP0001905_abnormal_dopamine_level1.01946596
73MP0003283_abnormal_digestive_organ1.01550131
74MP0001485_abnormal_pinna_reflex1.01187372
75MP0004142_abnormal_muscle_tone0.99569289
76MP0004043_abnormal_pH_regulation0.98549487
77MP0003633_abnormal_nervous_system0.97159852
78MP0002152_abnormal_brain_morphology0.96375915
79MP0003136_yellow_coat_color0.96274608
80MP0002752_abnormal_somatic_nervous0.96133547
81MP0002638_abnormal_pupillary_reflex0.95999438
82MP0000372_irregular_coat_pigmentation0.95348033
83MP0009780_abnormal_chondrocyte_physiolo0.94617124
84MP0004233_abnormal_muscle_weight0.94459589
85MP0005085_abnormal_gallbladder_physiolo0.94008407
86MP0001765_abnormal_ion_homeostasis0.93764004
87MP0001963_abnormal_hearing_physiology0.92894876
88MP0000631_abnormal_neuroendocrine_gland0.92195937
89MP0002837_dystrophic_cardiac_calcinosis0.91912520
90MP0004858_abnormal_nervous_system0.91589238
91MP0004924_abnormal_behavior0.91446192
92MP0005386_behavior/neurological_phenoty0.91446192
93MP0010386_abnormal_urinary_bladder0.90495668
94MP0001944_abnormal_pancreas_morphology0.89754487
95MP0002066_abnormal_motor_capabilities/c0.89711769
96MP0002282_abnormal_trachea_morphology0.89688491
97MP0003183_abnormal_peptide_metabolism0.88700091
98MP0002938_white_spotting0.86453890
99MP0005083_abnormal_biliary_tract0.85579345
100MP0003122_maternal_imprinting0.85169029
101MP0005636_abnormal_mineral_homeostasis0.82849857
102MP0005187_abnormal_penis_morphology0.82474626
103MP0005365_abnormal_bile_salt0.81205133
104MP0003631_nervous_system_phenotype0.79527306
105MP0004885_abnormal_endolymph0.78903797
106MP0005379_endocrine/exocrine_gland_phen0.76068495
107MP0005499_abnormal_olfactory_system0.75976893
108MP0005394_taste/olfaction_phenotype0.75976893
109MP0002168_other_aberrant_phenotype0.75901702
110MP0000026_abnormal_inner_ear0.75497087
111MP0005377_hearing/vestibular/ear_phenot0.75427798
112MP0003878_abnormal_ear_physiology0.75427798
113MP0003690_abnormal_glial_cell0.72590760
114MP0002876_abnormal_thyroid_physiology0.72085998
115MP0005195_abnormal_posterior_eye0.71718858
116MP0005171_absent_coat_pigmentation0.71686062
117MP0005670_abnormal_white_adipose0.71685264
118MP0003787_abnormal_imprinting0.67649806
119MP0005389_reproductive_system_phenotype0.64715077
120MP0008995_early_reproductive_senescence0.63519780
121MP0002928_abnormal_bile_duct0.63049648
122MP0005535_abnormal_body_temperature0.60768928
123MP0001324_abnormal_eye_pigmentation0.59341609

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.00641257
2Abnormal respiratory epithelium morphology (HP:0012253)7.99990929
3Abnormal respiratory motile cilium morphology (HP:0005938)7.99990929
4Abnormal ciliary motility (HP:0012262)7.56109573
5Rhinitis (HP:0012384)7.47075067
6Chronic bronchitis (HP:0004469)6.55660486
7Infertility (HP:0000789)4.85870675
8Bronchiectasis (HP:0002110)4.03668663
9Nephronophthisis (HP:0000090)4.00140660
10Nasal polyposis (HP:0100582)3.97835026
11Medial flaring of the eyebrow (HP:0010747)3.59665598
12Molar tooth sign on MRI (HP:0002419)3.39504075
13Abnormality of midbrain morphology (HP:0002418)3.39504075
14Bronchitis (HP:0012387)3.31783407
15Abnormality of the nasal mucosa (HP:0000433)3.04638445
16Abnormality of the renal medulla (HP:0100957)3.00621255
17Gait imbalance (HP:0002141)2.87481754
18Tubulointerstitial nephritis (HP:0001970)2.80962522
19Congenital primary aphakia (HP:0007707)2.78862125
20Male pseudohermaphroditism (HP:0000037)2.58142331
21Sclerocornea (HP:0000647)2.55961997
22Recurrent otitis media (HP:0000403)2.55646626
23Anencephaly (HP:0002323)2.52274936
24Male infertility (HP:0003251)2.51776117
25Nephrogenic diabetes insipidus (HP:0009806)2.45769341
26Retinal dysplasia (HP:0007973)2.44600774
27Pancreatic fibrosis (HP:0100732)2.44446073
28Atonic seizures (HP:0010819)2.42101764
29Furrowed tongue (HP:0000221)2.36038203
30True hermaphroditism (HP:0010459)2.30424596
31Recurrent sinusitis (HP:0011108)2.28943017
32Genital tract atresia (HP:0001827)2.23500762
33Postaxial hand polydactyly (HP:0001162)2.22082584
34Abnormality of the renal cortex (HP:0011035)2.20741101
35Focal motor seizures (HP:0011153)2.19903007
36Vaginal atresia (HP:0000148)2.18960771
37Postaxial foot polydactyly (HP:0001830)2.17768383
38Dyschromatopsia (HP:0007641)2.15081593
39Hemiparesis (HP:0001269)2.11067318
40Aplasia/Hypoplasia of the lens (HP:0008063)2.10282184
41Tubular atrophy (HP:0000092)2.08559842
42Oculomotor apraxia (HP:0000657)2.06017764
43Progressive cerebellar ataxia (HP:0002073)2.02835899
44Poor coordination (HP:0002370)2.01081521
45Atelectasis (HP:0100750)2.00689711
46Hyperactive renin-angiotensin system (HP:0000841)2.00306585
47Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6730850
48Absent/shortened dynein arms (HP:0200106)10.1251424
49Dynein arm defect of respiratory motile cilia (HP:0012255)10.1251424
50Decreased central vision (HP:0007663)1.98374507
51Chronic otitis media (HP:0000389)1.98363594
52Median cleft lip (HP:0000161)1.97893813
53Tubulointerstitial abnormality (HP:0001969)1.97201320
54Neurofibrillary tangles (HP:0002185)1.96629328
55Congenital hepatic fibrosis (HP:0002612)1.95945011
56Abnormal drinking behavior (HP:0030082)1.93537497
57Polydipsia (HP:0001959)1.93537497
58Chronic hepatic failure (HP:0100626)1.93531513
59Decreased circulating renin level (HP:0003351)1.93126589
60Epileptic encephalopathy (HP:0200134)1.88173181
61Preaxial hand polydactyly (HP:0001177)1.87334681
62Stage 5 chronic kidney disease (HP:0003774)1.86714150
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.83785113
64Abnormality of the dental root (HP:0006486)1.83458066
65Taurodontia (HP:0000679)1.83458066
66Abnormality of permanent molar morphology (HP:0011071)1.83458066
67Myokymia (HP:0002411)1.81532978
68Bifid tongue (HP:0010297)1.80818104
69Abnormal rod and cone electroretinograms (HP:0008323)1.79421151
70Cystic liver disease (HP:0006706)1.78500368
71Choroideremia (HP:0001139)1.77145993
72Abnormality of the dental pulp (HP:0006479)1.76880173
73Abnormality of dentin (HP:0010299)1.76850575
74Tubulointerstitial fibrosis (HP:0005576)1.75471455
75Bony spicule pigmentary retinopathy (HP:0007737)1.73794219
76Chronic sinusitis (HP:0011109)1.72114637
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.70302832
78Occipital encephalocele (HP:0002085)1.69079690
79Polyuria (HP:0000103)1.69004425
80Gonadotropin excess (HP:0000837)1.68259573
81Abnormality of molar (HP:0011077)1.67026947
82Abnormality of molar morphology (HP:0011070)1.67026947
83Renal salt wasting (HP:0000127)1.66610487
84Abnormal gallbladder physiology (HP:0012438)1.65330713
85Cholecystitis (HP:0001082)1.65330713
86Focal seizures (HP:0007359)1.64140822
87Congenital stationary night blindness (HP:0007642)1.62388992
88Retinitis pigmentosa (HP:0000510)1.61612167
89Large for gestational age (HP:0001520)1.61486838
90Pancreatic cysts (HP:0001737)1.61218166
91Abnormal spermatogenesis (HP:0008669)1.60647470
92Asplenia (HP:0001746)1.59176394
93Attenuation of retinal blood vessels (HP:0007843)1.57878510
94Optic disc pallor (HP:0000543)1.57338920
95Bell-shaped thorax (HP:0001591)1.57326549
96Cerebral inclusion bodies (HP:0100314)1.56609202
97Absence seizures (HP:0002121)1.56366517
98Abnormality of macular pigmentation (HP:0008002)1.55799305
99Abnormality of renal excretion (HP:0011036)1.54097771
100Narrow forehead (HP:0000341)1.52269987
101Absent speech (HP:0001344)1.52261841
102Fibular hypoplasia (HP:0003038)1.52134175
103Type II lissencephaly (HP:0007260)1.51959620
104Abnormal biliary tract physiology (HP:0012439)1.51521847
105Bile duct proliferation (HP:0001408)1.51521847
106Retinal atrophy (HP:0001105)1.51358422
107Specific learning disability (HP:0001328)1.50424900
108Supranuclear gaze palsy (HP:0000605)1.49317122
109Febrile seizures (HP:0002373)1.47604554
110Hyperventilation (HP:0002883)1.47296457
111Hyperaldosteronism (HP:0000859)1.45731933
112Central scotoma (HP:0000603)1.45655056
113Aganglionic megacolon (HP:0002251)1.44943711
114Abnormality of renin-angiotensin system (HP:0000847)1.44738816
115Nephropathy (HP:0000112)1.43739984
116Visual hallucinations (HP:0002367)1.43338229
117Acute necrotizing encephalopathy (HP:0006965)1.43311288
118Microglossia (HP:0000171)1.42969700
119Progressive inability to walk (HP:0002505)1.42352560
120Supernumerary spleens (HP:0009799)1.42175951
121Left ventricular hypertrophy (HP:0001712)1.42137983
122Renal dysplasia (HP:0000110)1.40427523
123Polyphagia (HP:0002591)1.40177706
124Prominent nasal bridge (HP:0000426)1.40095498
125Broad-based gait (HP:0002136)1.37546107
126Abnormal urine output (HP:0012590)1.35317244
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.35156410
128Progressive macrocephaly (HP:0004481)1.34658383
129Agitation (HP:0000713)1.34221723
130Aplasia/Hypoplasia of the tibia (HP:0005772)1.33020895
131Multicystic kidney dysplasia (HP:0000003)1.31557022
132Abolished electroretinogram (ERG) (HP:0000550)1.30928059
133Broad foot (HP:0001769)1.29572780
134Abnormality of abdominal situs (HP:0011620)1.26587464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.06094762
2PDK46.06094762
3PRKD34.70426807
4TESK14.19625323
5PDK23.74089409
6FRK3.46999094
7PNCK3.45094124
8MAPK152.99115565
9ICK2.97042008
10MST42.36902450
11WNK42.33970651
12STK392.24415094
13MAP4K22.18407653
14PTK2B2.03894171
15NTRK31.94652724
16CASK1.93785793
17MAP3K41.77505168
18NTRK21.70976440
19MAP2K71.69468036
20MAPKAPK31.63329031
21STK381.62669916
22MARK11.39104754
23ERBB31.35386053
24PHKG11.33311362
25PHKG21.33311362
26WNK31.29323262
27ACVR1B1.28926648
28FGFR21.28583594
29TLK11.28282994
30INSRR1.24712456
31MUSK1.22093290
32EPHA21.21587833
33MINK11.17853728
34EPHA31.17337576
35WNK11.13963605
36TNIK1.12226507
37PRKCG1.10522689
38BCR1.09868975
39BMPR1B1.00706759
40MAPK130.98775205
41PRPF4B0.96431059
42GRK50.95632147
43EPHA40.92485005
44LMTK20.91897112
45TYRO30.86055103
46TSSK60.84437341
47CAMK1G0.82408910
48DYRK20.81559553
49DYRK1B0.80929509
50ARAF0.80494943
51AKT30.79923517
52IRAK10.77515207
53CAMK2A0.75364593
54PDK10.74658055
55OXSR10.72286841
56WEE10.67420078
57NTRK10.67285688
58BRAF0.67113973
59CSNK1G20.67053042
60CDK50.66739456
61MAP2K40.66570558
62SGK4940.65911561
63SGK2230.65911561
64PLK20.65694492
65TAOK10.64412049
66TIE10.63174617
67PAK60.61429460
68CCNB10.60091441
69MAP3K120.59361017
70RIPK40.59265013
71PINK10.58881072
72PAK30.57376810
73IRAK20.56604267
74PRKCI0.54831078
75STK240.54444722
76VRK10.53977276
77MAP3K90.53682049
78CAMK2B0.52592879
79DAPK20.52335823
80PDPK10.52152998
81NEK60.51551428
82TRIM280.50397124
83SGK20.50080695
84NLK0.49046174
85STK160.48690157
86CAMK2D0.47977548
87OBSCN0.47598839
88DAPK10.46670662
89ROCK10.46154201
90BCKDK0.45789648
91MAP3K20.45625981
92CAMKK10.45200673
93CSNK1G10.43704822
94MAPKAPK50.42473534
95TRPM70.42014115
96CDK30.41829273
97DYRK1A0.41724041
98CSNK1G30.40419266
99ERBB20.39329746
100TAOK30.38866585
101FES0.38631228
102FER0.38402807
103LIMK10.37282647
104CAMK2G0.37022806
105CDK140.36877742
106MAP3K70.36637279
107PRKAA20.36589619
108PRKCE0.36318483
109PRKCZ0.35944559
110PASK0.35708288
111PRKACA0.35375900
112BMPR20.33732567
113GRK70.32618001
114NUAK10.31953201
115PRKG10.31833525
116CDK180.31831684
117NME10.31601387
118ADRBK20.31095485
119STK110.30828766
120STK38L0.30683443
121CDK150.30661747
122PKN10.30345880
123CDK190.30066552
124CSNK1A1L0.28791040
125MARK20.28748607
126UHMK10.26407489
127GRK10.26224733
128CDK11A0.25499375
129RPS6KB10.25478415
130PRKCA0.23156300
131PRKACG0.23147684
132CAMKK20.22359538
133RPS6KA30.22209930
134DYRK30.22005790
135RPS6KA20.21623730
136ADRBK10.20717633
137PRKCQ0.19995630
138PRKCB0.19386341
139CAMK10.19140187

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97490651
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.90717076
3Olfactory transduction_Homo sapiens_hsa047402.88762277
4Synaptic vesicle cycle_Homo sapiens_hsa047212.67129093
5Nicotine addiction_Homo sapiens_hsa050332.65435067
6Phototransduction_Homo sapiens_hsa047442.64655533
7Chemical carcinogenesis_Homo sapiens_hsa052042.60971303
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.54636836
9Butanoate metabolism_Homo sapiens_hsa006502.41773361
10Collecting duct acid secretion_Homo sapiens_hsa049662.41022582
11Fatty acid biosynthesis_Homo sapiens_hsa000612.35879742
12Amphetamine addiction_Homo sapiens_hsa050312.33970328
13Histidine metabolism_Homo sapiens_hsa003402.16651449
14Insulin secretion_Homo sapiens_hsa049112.15654561
15Pyruvate metabolism_Homo sapiens_hsa006202.14850370
16beta-Alanine metabolism_Homo sapiens_hsa004102.10817366
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.09900415
18Oxidative phosphorylation_Homo sapiens_hsa001902.06471643
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.05679086
20Vitamin B6 metabolism_Homo sapiens_hsa007501.99324183
21Huntingtons disease_Homo sapiens_hsa050161.94817366
22Taste transduction_Homo sapiens_hsa047421.91675427
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.91629386
24Phenylalanine metabolism_Homo sapiens_hsa003601.88950209
25GABAergic synapse_Homo sapiens_hsa047271.84516078
26Circadian entrainment_Homo sapiens_hsa047131.81568726
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.77141400
28Glucagon signaling pathway_Homo sapiens_hsa049221.75865404
29Long-term potentiation_Homo sapiens_hsa047201.74640105
30Dorso-ventral axis formation_Homo sapiens_hsa043201.72267234
31Glutamatergic synapse_Homo sapiens_hsa047241.72019383
32Cardiac muscle contraction_Homo sapiens_hsa042601.71308546
33Morphine addiction_Homo sapiens_hsa050321.67646159
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67364519
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.64492545
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62873799
37Tyrosine metabolism_Homo sapiens_hsa003501.62385833
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.59581657
39Caffeine metabolism_Homo sapiens_hsa002321.59512335
40Vibrio cholerae infection_Homo sapiens_hsa051101.54302961
41Tryptophan metabolism_Homo sapiens_hsa003801.51570458
42Dopaminergic synapse_Homo sapiens_hsa047281.49691887
43Renin secretion_Homo sapiens_hsa049241.49200465
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46452468
45Parkinsons disease_Homo sapiens_hsa050121.46404461
46Retinol metabolism_Homo sapiens_hsa008301.46016099
47Alzheimers disease_Homo sapiens_hsa050101.45712327
48Glutathione metabolism_Homo sapiens_hsa004801.43522668
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41589795
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39557818
51Peroxisome_Homo sapiens_hsa041461.39425357
52Salivary secretion_Homo sapiens_hsa049701.33963240
53Cocaine addiction_Homo sapiens_hsa050301.33898723
54Nitrogen metabolism_Homo sapiens_hsa009101.30062037
55ABC transporters_Homo sapiens_hsa020101.29012880
56Calcium signaling pathway_Homo sapiens_hsa040201.23022265
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.22889976
58Gastric acid secretion_Homo sapiens_hsa049711.20817760
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.20569007
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19218800
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18775693
62Linoleic acid metabolism_Homo sapiens_hsa005911.11211899
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07908508
64Propanoate metabolism_Homo sapiens_hsa006401.04899154
65Ether lipid metabolism_Homo sapiens_hsa005651.04105448
66Serotonergic synapse_Homo sapiens_hsa047261.02466143
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01916680
68cAMP signaling pathway_Homo sapiens_hsa040241.00402542
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96335410
70Oocyte meiosis_Homo sapiens_hsa041140.95196662
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94685770
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94158276
73Mineral absorption_Homo sapiens_hsa049780.93793645
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.93511761
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92391381
76Cholinergic synapse_Homo sapiens_hsa047250.91791932
77Estrogen signaling pathway_Homo sapiens_hsa049150.91756937
78Arachidonic acid metabolism_Homo sapiens_hsa005900.91718510
79Basal transcription factors_Homo sapiens_hsa030220.91192444
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91118133
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88700632
82Glycerolipid metabolism_Homo sapiens_hsa005610.86659894
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.86631015
84Sulfur metabolism_Homo sapiens_hsa009200.85551595
85Regulation of autophagy_Homo sapiens_hsa041400.83214827
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79233604
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75282860
88Protein export_Homo sapiens_hsa030600.75087267
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.73895798
90Fructose and mannose metabolism_Homo sapiens_hsa000510.73494311
91Pancreatic secretion_Homo sapiens_hsa049720.72976196
92Hedgehog signaling pathway_Homo sapiens_hsa043400.71818437
93Thyroid hormone synthesis_Homo sapiens_hsa049180.71746548
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71058920
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70507160
96Oxytocin signaling pathway_Homo sapiens_hsa049210.70380935
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70297884
98Alcoholism_Homo sapiens_hsa050340.64964839
99Arginine and proline metabolism_Homo sapiens_hsa003300.63750701
100Sphingolipid metabolism_Homo sapiens_hsa006000.62465173
101Basal cell carcinoma_Homo sapiens_hsa052170.62438927
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62049181
103Type II diabetes mellitus_Homo sapiens_hsa049300.61594450
104Steroid biosynthesis_Homo sapiens_hsa001000.61454789
105Fatty acid metabolism_Homo sapiens_hsa012120.60410735
106Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59311558
107Tight junction_Homo sapiens_hsa045300.56547241
108PPAR signaling pathway_Homo sapiens_hsa033200.56353537
109Long-term depression_Homo sapiens_hsa047300.54793324
110Melanogenesis_Homo sapiens_hsa049160.53316867
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52023569
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51692887
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51447029
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.51413887
115N-Glycan biosynthesis_Homo sapiens_hsa005100.47502131
116Type I diabetes mellitus_Homo sapiens_hsa049400.46471599
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46072348
118Purine metabolism_Homo sapiens_hsa002300.44073393
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43414113
120Wnt signaling pathway_Homo sapiens_hsa043100.42856346
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42777641
122Phagosome_Homo sapiens_hsa041450.42646307
123Circadian rhythm_Homo sapiens_hsa047100.42052739
124Ovarian steroidogenesis_Homo sapiens_hsa049130.41506600
125Rheumatoid arthritis_Homo sapiens_hsa053230.41316786
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40061863
127Axon guidance_Homo sapiens_hsa043600.38485619
128Inositol phosphate metabolism_Homo sapiens_hsa005620.36985978
129RNA polymerase_Homo sapiens_hsa030200.35557880
130Bile secretion_Homo sapiens_hsa049760.34177837
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33697065
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31547634
133Gap junction_Homo sapiens_hsa045400.30971020
134Metabolic pathways_Homo sapiens_hsa011000.29905583
135Fatty acid degradation_Homo sapiens_hsa000710.29590793
136Hippo signaling pathway_Homo sapiens_hsa043900.29282845
137GnRH signaling pathway_Homo sapiens_hsa049120.29036938
138Drug metabolism - other enzymes_Homo sapiens_hsa009830.28762450

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