ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.71450076
2	behavioral response to nicotine (GO:0035095)	4.55218592
3	piRNA metabolic process (GO:0034587)	4.27002009
4	fucose catabolic process (GO:0019317)	4.09112615
5	L-fucose metabolic process (GO:0042354)	4.09112615
6	L-fucose catabolic process (GO:0042355)	4.09112615
7	epithelial cilium movement (GO:0003351)	4.07028392
8	cilium or flagellum-dependent cell motility (GO:0001539)	4.04334842
9	axoneme assembly (GO:0035082)	3.95790271
10	cilium movement (GO:0003341)	3.66120648
11	kynurenine metabolic process (GO:0070189)	3.64497559
12	regulation of meiosis I (GO:0060631)	3.59054804
13	indole-containing compound catabolic process (GO:0042436)	3.55646838
14	indolalkylamine catabolic process (GO:0046218)	3.55646838
15	tryptophan catabolic process (GO:0006569)	3.55646838
16	intraciliary transport (GO:0042073)	3.39826636
17	response to pheromone (GO:0019236)	3.37458541
18	cilium morphogenesis (GO:0060271)	3.36596187
19	regulation of cilium movement (GO:0003352)	3.36563863
20	cilium organization (GO:0044782)	3.34839526
21	protein localization to cilium (GO:0061512)	3.31008408
22	cilium assembly (GO:0042384)	3.27653621
23	protein polyglutamylation (GO:0018095)	3.26066460
24	DNA methylation involved in gamete generation (GO:0043046)	3.21172491
25	indolalkylamine metabolic process (GO:0006586)	3.20049579
26	synapsis (GO:0007129)	3.16105042
27	axonemal dynein complex assembly (GO:0070286)	3.15641053
28	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.14562633
29	nonmotile primary cilium assembly (GO:0035058)	3.12631332
30	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.11395588
31	rRNA catabolic process (GO:0016075)	3.09059126
32	male meiosis I (GO:0007141)	3.05628782
33	tryptophan metabolic process (GO:0006568)	3.02567556
34	centriole replication (GO:0007099)	3.00652954
35	reciprocal meiotic recombination (GO:0007131)	2.96683034
36	reciprocal DNA recombination (GO:0035825)	2.96683034
37	photoreceptor cell maintenance (GO:0045494)	2.92733153
38	behavioral response to ethanol (GO:0048149)	2.90784356
39	establishment of protein localization to Golgi (GO:0072600)	2.90128223
40	neural tube formation (GO:0001841)	2.87038228
41	oxidative demethylation (GO:0070989)	2.83540849
42	retinal cone cell development (GO:0046549)	2.83196153
43	male meiosis (GO:0007140)	2.82343062
44	negative regulation of telomere maintenance (GO:0032205)	2.81511307
45	reflex (GO:0060004)	2.80817721
46	DNA double-strand break processing (GO:0000729)	2.79340224
47	neuronal action potential (GO:0019228)	2.75479309
48	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.72371988
49	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.72371988
50	cellular ketone body metabolic process (GO:0046950)	2.72212164
51	water-soluble vitamin biosynthetic process (GO:0042364)	2.71521881
52	respiratory chain complex IV assembly (GO:0008535)	2.71084803
53	sperm motility (GO:0030317)	2.67212594
54	gamma-aminobutyric acid transport (GO:0015812)	2.65671227
55	replication fork processing (GO:0031297)	2.63910568
56	detection of light stimulus involved in visual perception (GO:0050908)	2.63632197
57	detection of light stimulus involved in sensory perception (GO:0050962)	2.63632197
58	multicellular organism reproduction (GO:0032504)	2.60852496
59	indole-containing compound metabolic process (GO:0042430)	2.60225342
60	cellular component assembly involved in morphogenesis (GO:0010927)	2.59931436
61	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.58015904
62	cornea development in camera-type eye (GO:0061303)	2.57868871
63	recombinational repair (GO:0000725)	2.57412998
64	meiotic chromosome segregation (GO:0045132)	2.56892875
65	double-strand break repair via homologous recombination (GO:0000724)	2.56697123
66	sulfation (GO:0051923)	2.55696096
67	regulation of microtubule-based movement (GO:0060632)	2.55603785
68	preassembly of GPI anchor in ER membrane (GO:0016254)	2.55068919
69	platelet dense granule organization (GO:0060155)	2.54330466
70	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.53398888
71	negative regulation of systemic arterial blood pressure (GO:0003085)	2.50799548
72	prenylation (GO:0097354)	2.49960850
73	protein prenylation (GO:0018342)	2.49960850
74	primary amino compound metabolic process (GO:1901160)	2.49865122
75	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.49229355
76	ubiquinone metabolic process (GO:0006743)	2.47613425
77	acrosome reaction (GO:0007340)	2.46726057
78	ubiquinone biosynthetic process (GO:0006744)	2.43553213
79	kidney morphogenesis (GO:0060993)	2.42797600
80	DNA deamination (GO:0045006)	2.41889503
81	resolution of meiotic recombination intermediates (GO:0000712)	2.40384795
82	ketone body metabolic process (GO:1902224)	2.40189332
83	signal peptide processing (GO:0006465)	2.39384554
84	protein-cofactor linkage (GO:0018065)	2.37914902
85	motile cilium assembly (GO:0044458)	2.37494089
86	photoreceptor cell development (GO:0042461)	2.36429743
87	protein complex biogenesis (GO:0070271)	2.36356612
88	regulation of telomere maintenance (GO:0032204)	2.36217545
89	protein K11-linked deubiquitination (GO:0035871)	2.35987237
90	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.35946448
91	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.35946448
92	regulation of translation, ncRNA-mediated (GO:0045974)	2.35946448
93	positive regulation of meiosis (GO:0045836)	2.35829649
94	smoothened signaling pathway (GO:0007224)	2.35761233
95	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.32930969
96	meiosis I (GO:0007127)	2.32599353
97	anterograde synaptic vesicle transport (GO:0048490)	2.32598373
98	regulation of hexokinase activity (GO:1903299)	2.32426698
99	regulation of glucokinase activity (GO:0033131)	2.32426698
100	positive regulation of mitochondrial fission (GO:0090141)	2.32246524

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.77527175
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.00800567
3	VDR_22108803_ChIP-Seq_LS180_Human	2.94938021
4	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.81505912
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70494486
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69728998
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.63464751
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.54067626
9	FUS_26573619_Chip-Seq_HEK293_Human	2.43105687
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36798255
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.34862812
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.34861444
13	EWS_26573619_Chip-Seq_HEK293_Human	2.33115206
14	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.20933086
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15188797
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.13800412
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.12701192
18	P300_19829295_ChIP-Seq_ESCs_Human	2.11839938
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.01734763
20	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93851490
21	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91971692
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.90127777
23	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.83855220
24	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.78676116
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.78299624
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.71678196
27	* STAT3_23295773_ChIP-Seq_U87_Human	1.67266416
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.66419997
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65513078
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64763371
31	CBP_20019798_ChIP-Seq_JUKART_Human	1.64605070
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64605070
33	* PIAS1_25552417_ChIP-Seq_VCAP_Human	1.54857026
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.54341108
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.52538274
36	AR_25329375_ChIP-Seq_VCAP_Human	1.52211753
37	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.50566259
38	TCF4_23295773_ChIP-Seq_U87_Human	1.49532718
39	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48010717
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.47479615
41	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46496213
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.44307190
43	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.43499772
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.41596358
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40237848
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.39645943
47	MYC_18940864_ChIP-ChIP_HL60_Human	1.37409380
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.36460110
49	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.36052730
50	TCF4_22108803_ChIP-Seq_LS180_Human	1.35103412
51	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.33390502
52	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32829733
53	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32273136
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.32051155
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31724337
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31724337
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30289506
58	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30289506
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.29703367
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29625111
61	ELK1_19687146_ChIP-ChIP_HELA_Human	1.29433244
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27818142
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27220839
64	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27142816
65	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.26117553
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26033278
67	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26033278
68	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25275161
69	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24338876
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23296822
71	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.22776757
72	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.21458590
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.20887528
74	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.20774699
75	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.20583694
76	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19102191
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17647469
78	REST_21632747_ChIP-Seq_MESCs_Mouse	1.16386851
79	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15857862
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.15435810
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13104840
82	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09520121
83	AR_21572438_ChIP-Seq_LNCaP_Human	1.09399136
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07906163
85	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.07835366
86	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.07186075
87	AR_20517297_ChIP-Seq_VCAP_Human	1.06813936
88	VDR_23849224_ChIP-Seq_CD4+_Human	1.06112758
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.05816943
90	NCOR_22424771_ChIP-Seq_293T_Human	1.05134345
91	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.04676000
92	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.04531939
93	CDX2_22108803_ChIP-Seq_LS180_Human	1.04423040
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.03667743
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.03081191
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02117468
97	JUN_21703547_ChIP-Seq_K562_Human	1.01563582
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01013334
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00754952
100	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.98636372

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.53429618
2	MP0003195_calcinosis	2.65028003
3	MP0005551_abnormal_eye_electrophysiolog	2.35821927
4	MP0002102_abnormal_ear_morphology	2.34264629
5	MP0009046_muscle_twitch	2.28504285
6	MP0006072_abnormal_retinal_apoptosis	2.18763147
7	MP0002837_dystrophic_cardiac_calcinosis	2.12584467
8	MP0003787_abnormal_imprinting	2.10151556
9	MP0000569_abnormal_digit_pigmentation	2.09581732
10	MP0005253_abnormal_eye_physiology	1.96099866
11	MP0001968_abnormal_touch/_nociception	1.94407588
12	MP0008058_abnormal_DNA_repair	1.93441985
13	MP0004885_abnormal_endolymph	1.92551758
14	MP0004133_heterotaxia	1.91862386
15	MP0004147_increased_porphyrin_level	1.85200753
16	MP0000427_abnormal_hair_cycle	1.84501423
17	MP0005645_abnormal_hypothalamus_physiol	1.82612084
18	MP0009745_abnormal_behavioral_response	1.79298732
19	MP0005646_abnormal_pituitary_gland	1.79208274
20	MP0003646_muscle_fatigue	1.76188828
21	MP0003136_yellow_coat_color	1.73118228
22	MP0003890_abnormal_embryonic-extraembry	1.70106060
23	MP0006292_abnormal_olfactory_placode	1.69437184
24	MP0004142_abnormal_muscle_tone	1.69267261
25	MP0004043_abnormal_pH_regulation	1.69242091
26	MP0008872_abnormal_physiological_respon	1.66169590
27	MP0008875_abnormal_xenobiotic_pharmacok	1.65925537
28	MP0002272_abnormal_nervous_system	1.64989432
29	MP0002638_abnormal_pupillary_reflex	1.63411174
30	MP0003880_abnormal_central_pattern	1.63007306
31	MP0002736_abnormal_nociception_after	1.62766918
32	MP0001984_abnormal_olfaction	1.61776735
33	MP0006276_abnormal_autonomic_nervous	1.51682327
34	MP0002653_abnormal_ependyma_morphology	1.51101379
35	MP0000631_abnormal_neuroendocrine_gland	1.48141325
36	MP0002938_white_spotting	1.44658441
37	MP0001486_abnormal_startle_reflex	1.42445840
38	MP0001485_abnormal_pinna_reflex	1.42076013
39	MP0000383_abnormal_hair_follicle	1.40754631
40	MP0001501_abnormal_sleep_pattern	1.39332993
41	MP0002160_abnormal_reproductive_system	1.37838921
42	MP0001529_abnormal_vocalization	1.37573681
43	MP0002572_abnormal_emotion/affect_behav	1.36497759
44	MP0003718_maternal_effect	1.36244326
45	MP0003698_abnormal_male_reproductive	1.33790483
46	MP0001929_abnormal_gametogenesis	1.32731454
47	MP0003011_delayed_dark_adaptation	1.29259818
48	MP0000372_irregular_coat_pigmentation	1.28258206
49	MP0005410_abnormal_fertilization	1.25283706
50	MP0002210_abnormal_sex_determination	1.23955334
51	MP0005174_abnormal_tail_pigmentation	1.23790921
52	MP0010386_abnormal_urinary_bladder	1.23167676
53	MP0002557_abnormal_social/conspecific_i	1.19903011
54	MP0001986_abnormal_taste_sensitivity	1.18010607
55	MP0008995_early_reproductive_senescence	1.17367061
56	MP0005084_abnormal_gallbladder_morpholo	1.17136369
57	MP0004145_abnormal_muscle_electrophysio	1.17115754
58	MP0004215_abnormal_myocardial_fiber	1.14906477
59	MP0005389_reproductive_system_phenotype	1.13710107
60	MP0002876_abnormal_thyroid_physiology	1.13620132
61	MP0002064_seizures	1.12844350
62	MP0002067_abnormal_sensory_capabilities	1.12373692
63	MP0008057_abnormal_DNA_replication	1.10962949
64	MP0000778_abnormal_nervous_system	1.09314708
65	MP0005386_behavior/neurological_phenoty	1.08875874
66	MP0004924_abnormal_behavior	1.08875874
67	MP0000653_abnormal_sex_gland	1.05962709
68	MP0002063_abnormal_learning/memory/cond	1.05829375
69	MP0003937_abnormal_limbs/digits/tail_de	1.05182987
70	MP0002928_abnormal_bile_duct	1.04886238
71	MP0000647_abnormal_sebaceous_gland	1.04469100
72	MP0001970_abnormal_pain_threshold	1.04322747
73	MP0004742_abnormal_vestibular_system	1.04043496
74	MP0002735_abnormal_chemical_nociception	1.02423249
75	MP0001145_abnormal_male_reproductive	1.02168376
76	MP0002734_abnormal_mechanical_nocicepti	1.01650494
77	MP0003635_abnormal_synaptic_transmissio	1.01041815
78	MP0002751_abnormal_autonomic_nervous	1.00729383
79	MP0002234_abnormal_pharynx_morphology	1.00514174
80	MP0003119_abnormal_digestive_system	1.00445084
81	MP0001188_hyperpigmentation	1.00037485
82	MP0002733_abnormal_thermal_nociception	0.99557648
83	MP0003121_genomic_imprinting	0.99530898
84	MP0005195_abnormal_posterior_eye	0.98186845
85	MP0002184_abnormal_innervation	0.93773094
86	MP0005379_endocrine/exocrine_gland_phen	0.93258646
87	MP0002229_neurodegeneration	0.93226319
88	MP0008775_abnormal_heart_ventricle	0.89799942
89	MP0002752_abnormal_somatic_nervous	0.89420748
90	MP0002095_abnormal_skin_pigmentation	0.88944148
91	MP0002163_abnormal_gland_morphology	0.87375534
92	MP0002909_abnormal_adrenal_gland	0.86145261
93	MP0005391_vision/eye_phenotype	0.85604993
94	MP0001324_abnormal_eye_pigmentation	0.85560296
95	MP0008961_abnormal_basal_metabolism	0.84171630
96	MP0001905_abnormal_dopamine_level	0.82530072
97	MP0001963_abnormal_hearing_physiology	0.82161622
98	MP0010094_abnormal_chromosome_stability	0.81684345
99	MP0001293_anophthalmia	0.81490707
100	MP0000026_abnormal_inner_ear	0.79579855

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.83771711
2	Pancreatic fibrosis (HP:0100732)	4.59672078
3	True hermaphroditism (HP:0010459)	4.33392294
4	Molar tooth sign on MRI (HP:0002419)	4.32061759
5	Abnormality of midbrain morphology (HP:0002418)	4.32061759
6	Nephronophthisis (HP:0000090)	4.16318319
7	Medial flaring of the eyebrow (HP:0010747)	3.69001675
8	Abnormality of the renal medulla (HP:0100957)	3.65305231
9	Abnormality of the renal cortex (HP:0011035)	3.46975477
10	Cystic liver disease (HP:0006706)	3.16566126
11	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.14858952
12	Absent/shortened dynein arms (HP:0200106)	3.14858952
13	Congenital stationary night blindness (HP:0007642)	3.08476673
14	Gait imbalance (HP:0002141)	3.04943367
15	Attenuation of retinal blood vessels (HP:0007843)	3.02913101
16	Congenital primary aphakia (HP:0007707)	3.02605046
17	Chronic hepatic failure (HP:0100626)	2.91906736
18	Hyperventilation (HP:0002883)	2.87752509
19	Type II lissencephaly (HP:0007260)	2.84955042
20	Nephrogenic diabetes insipidus (HP:0009806)	2.83998248
21	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.82795124
22	Abnormality of alanine metabolism (HP:0010916)	2.82795124
23	Hyperalaninemia (HP:0003348)	2.82795124
24	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.77697844
25	Tubular atrophy (HP:0000092)	2.77307540
26	Abnormal respiratory epithelium morphology (HP:0012253)	2.77003554
27	Abnormal respiratory motile cilium morphology (HP:0005938)	2.77003554
28	Sclerocornea (HP:0000647)	2.75660524
29	Abnormal ciliary motility (HP:0012262)	2.68106009
30	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.63923170
31	Abolished electroretinogram (ERG) (HP:0000550)	2.51671078
32	Genital tract atresia (HP:0001827)	2.51464813
33	Renal cortical cysts (HP:0000803)	2.46162603
34	Postaxial foot polydactyly (HP:0001830)	2.44997703
35	Gaze-evoked nystagmus (HP:0000640)	2.42494561
36	Vaginal atresia (HP:0000148)	2.42014339
37	Congenital hepatic fibrosis (HP:0002612)	2.40977798
38	Abnormal respiratory motile cilium physiology (HP:0012261)	2.40313923
39	Anencephaly (HP:0002323)	2.40095749
40	Inability to walk (HP:0002540)	2.28481181
41	Poor coordination (HP:0002370)	2.28301762
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.24879262
43	Furrowed tongue (HP:0000221)	2.24133086
44	Preaxial hand polydactyly (HP:0001177)	2.22393226
45	Lissencephaly (HP:0001339)	2.20684208
46	Progressive inability to walk (HP:0002505)	2.17993004
47	Polydipsia (HP:0001959)	2.17302498
48	Abnormal drinking behavior (HP:0030082)	2.17302498
49	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.16679338
50	Abnormal biliary tract physiology (HP:0012439)	2.15630766
51	Bile duct proliferation (HP:0001408)	2.15630766
52	Tubulointerstitial nephritis (HP:0001970)	2.14465580
53	Progressive cerebellar ataxia (HP:0002073)	2.11080099
54	Male pseudohermaphroditism (HP:0000037)	2.08532312
55	Cerebellar dysplasia (HP:0007033)	2.05363947
56	Increased corneal curvature (HP:0100692)	2.05170064
57	Keratoconus (HP:0000563)	2.05170064
58	Postaxial hand polydactyly (HP:0001162)	2.04451200
59	Protruding tongue (HP:0010808)	2.01850974
60	Tubulointerstitial abnormality (HP:0001969)	1.99672648
61	Genetic anticipation (HP:0003743)	1.97517790
62	Decreased central vision (HP:0007663)	1.97202547
63	Concave nail (HP:0001598)	1.97045739
64	Bony spicule pigmentary retinopathy (HP:0007737)	1.92510269
65	Abnormality of the labia minora (HP:0012880)	1.91231645
66	Broad-based gait (HP:0002136)	1.90680883
67	Occipital encephalocele (HP:0002085)	1.88654442
68	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.87498423
69	Fair hair (HP:0002286)	1.86318508
70	Retinal dysplasia (HP:0007973)	1.86179404
71	Rhinitis (HP:0012384)	1.86046376
72	Pendular nystagmus (HP:0012043)	1.84884011
73	Volvulus (HP:0002580)	1.81302374
74	Oligodactyly (hands) (HP:0001180)	1.81187500
75	Hypothermia (HP:0002045)	1.80734390
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80550545
77	Patellar aplasia (HP:0006443)	1.80336629
78	Febrile seizures (HP:0002373)	1.79265124
79	Short tibia (HP:0005736)	1.78428663
80	Chorioretinal atrophy (HP:0000533)	1.78229059
81	Methylmalonic acidemia (HP:0002912)	1.77726273
82	Dandy-Walker malformation (HP:0001305)	1.77581432
83	Abnormality of macular pigmentation (HP:0008002)	1.77432554
84	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.77214607
85	Colon cancer (HP:0003003)	1.77129641
86	Large for gestational age (HP:0001520)	1.76579328
87	Narrow forehead (HP:0000341)	1.76577627
88	Polyuria (HP:0000103)	1.76067196
89	Astigmatism (HP:0000483)	1.75787372
90	Oculomotor apraxia (HP:0000657)	1.72992840
91	Sloping forehead (HP:0000340)	1.72923021
92	Constricted visual fields (HP:0001133)	1.72855564
93	Increased CSF lactate (HP:0002490)	1.72684826
94	Aganglionic megacolon (HP:0002251)	1.71653835
95	Aplasia/Hypoplasia of the patella (HP:0006498)	1.70516791
96	Specific learning disability (HP:0001328)	1.69848562
97	Optic nerve hypoplasia (HP:0000609)	1.69618739
98	Prominent nasal bridge (HP:0000426)	1.69050038
99	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.69005977
100	Intestinal atresia (HP:0011100)	1.68335079

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.00864572
2	MAP4K2	3.56980133
3	BMPR1B	3.19617333
4	ZAK	2.76431944
5	PNCK	2.75548958
6	NUAK1	2.52044211
7	ACVR1B	2.43000434
8	ADRBK2	2.28687715
9	MAP3K4	2.27535896
10	WNK3	2.27236395
11	CASK	2.17716642
12	INSRR	2.16574878
13	TAOK3	2.07352968
14	GRK1	1.84495520
15	TLK1	1.70046970
16	WNK4	1.69641198
17	PINK1	1.62217881
18	MKNK2	1.61874649
19	OXSR1	1.55363508
20	MAP2K7	1.43348082
21	CDK19	1.43077651
22	MAPK13	1.40778131
23	PLK4	1.37149379
24	TRIM28	1.35701523
25	STK39	1.19479283
26	PLK2	1.19338612
27	BCR	1.14644825
28	MST4	1.14208685
29	TNIK	1.12674593
30	CSNK1G2	1.11127939
31	STK38L	1.07649476
32	TGFBR1	1.02298072
33	CSNK1G1	0.99816915
34	TSSK6	0.98127922
35	ADRBK1	0.97361233
36	MAPK15	0.96212081
37	CSNK1G3	0.95750803
38	PTK2B	0.94910767
39	MKNK1	0.94889709
40	CAMKK2	0.94302780
41	PRKCE	0.92993555
42	PRKCG	0.90199242
43	CSNK1A1L	0.89565737
44	PAK3	0.89565317
45	DAPK2	0.88534583
46	MUSK	0.87528374
47	NTRK3	0.86186009
48	EIF2AK3	0.84042464
49	ERBB3	0.82786328
50	PLK3	0.81931129
51	TIE1	0.80142226
52	WEE1	0.79180534
53	MARK1	0.77810717
54	BCKDK	0.77197784
55	VRK1	0.75864821
56	MAPKAPK3	0.74043602
57	BRSK2	0.72318511
58	AKT3	0.70599172
59	STK3	0.65779737
60	CAMK1G	0.65173717
61	DYRK2	0.64654701
62	EPHA4	0.64381645
63	PLK1	0.64105952
64	PHKG2	0.60850619
65	PHKG1	0.60850619
66	TXK	0.58184933
67	MAPKAPK5	0.55756975
68	NEK1	0.55503468
69	MAP2K4	0.54801129
70	TRPM7	0.52291864
71	CAMK2A	0.49686035
72	PIK3CA	0.48962428
73	ATR	0.46006577
74	FGFR2	0.45467960
75	TAF1	0.45361730
76	DYRK3	0.45297645
77	ATM	0.44818254
78	MAP2K6	0.44028018
79	CHEK2	0.42405882
80	IRAK1	0.42402347
81	TEC	0.40859645
82	STK16	0.40591958
83	RPS6KA5	0.39765322
84	PRKCI	0.38084991
85	MET	0.37493381
86	CSNK1D	0.36635477
87	CSNK1A1	0.36240932
88	CDK3	0.35450841
89	NTRK2	0.33508734
90	PRKACA	0.32169191
91	PRKG1	0.31997237
92	TTK	0.31722225
93	FER	0.31377603
94	LATS1	0.31270775
95	NEK2	0.31060467
96	PKN1	0.30906033
97	PRKCQ	0.28256136
98	STK24	0.28220687
99	MAP3K12	0.27612705
100	NLK	0.27292972

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.73214039
2	Caffeine metabolism_Homo sapiens_hsa00232	2.57232123
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.43506818
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36382107
5	Protein export_Homo sapiens_hsa03060	2.29689466
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.27545403
7	Nicotine addiction_Homo sapiens_hsa05033	2.26967962
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22398060
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.19903206
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.16038859
11	Basal transcription factors_Homo sapiens_hsa03022	2.15703475
12	Butanoate metabolism_Homo sapiens_hsa00650	2.14750217
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.05884455
14	Homologous recombination_Homo sapiens_hsa03440	2.03952364
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02065987
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.00067659
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.85950593
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.82445891
19	Propanoate metabolism_Homo sapiens_hsa00640	1.74605468
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.73844792
21	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.72847530
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67928811
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.60270582
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.59734269
25	RNA polymerase_Homo sapiens_hsa03020	1.59701812
26	Taste transduction_Homo sapiens_hsa04742	1.58141763
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.54267095
28	RNA degradation_Homo sapiens_hsa03018	1.53815186
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.48942633
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.48557390
31	Regulation of autophagy_Homo sapiens_hsa04140	1.44160053
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.41705667
33	Olfactory transduction_Homo sapiens_hsa04740	1.41255950
34	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39582233
35	One carbon pool by folate_Homo sapiens_hsa00670	1.21803589
36	Morphine addiction_Homo sapiens_hsa05032	1.12779207
37	ABC transporters_Homo sapiens_hsa02010	1.11820011
38	Steroid biosynthesis_Homo sapiens_hsa00100	1.08414860
39	GABAergic synapse_Homo sapiens_hsa04727	1.07338139
40	Parkinsons disease_Homo sapiens_hsa05012	1.06629392
41	Peroxisome_Homo sapiens_hsa04146	1.05396251
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04619266
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03348361
44	Insulin secretion_Homo sapiens_hsa04911	1.02500497
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01963929
46	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.01915838
47	Huntingtons disease_Homo sapiens_hsa05016	0.98043571
48	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.96018967
49	Circadian entrainment_Homo sapiens_hsa04713	0.95233701
50	Serotonergic synapse_Homo sapiens_hsa04726	0.94076181
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91984963
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89672032
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.87377489
54	RNA transport_Homo sapiens_hsa03013	0.86350714
55	Purine metabolism_Homo sapiens_hsa00230	0.83724068
56	Salivary secretion_Homo sapiens_hsa04970	0.80490787
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.79409593
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.79073578
59	Retinol metabolism_Homo sapiens_hsa00830	0.78663724
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.78541980
61	Circadian rhythm_Homo sapiens_hsa04710	0.77947780
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.77643678
63	Cardiac muscle contraction_Homo sapiens_hsa04260	0.77175457
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.73304908
65	Mismatch repair_Homo sapiens_hsa03430	0.73184022
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71235682
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70328617
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.67982291
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67803493
70	Sulfur metabolism_Homo sapiens_hsa00920	0.67354905
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65599879
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.64908146
73	Metabolic pathways_Homo sapiens_hsa01100	0.63579000
74	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63133528
75	Calcium signaling pathway_Homo sapiens_hsa04020	0.63089003
76	Long-term depression_Homo sapiens_hsa04730	0.58723935
77	Fatty acid elongation_Homo sapiens_hsa00062	0.58222393
78	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56030299
79	Alzheimers disease_Homo sapiens_hsa05010	0.56017202
80	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54734696
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54470077
82	Proteasome_Homo sapiens_hsa03050	0.53785173
83	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.53596482
84	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53412869
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.53274122
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49759229
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.49192697
88	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48321399
89	Amphetamine addiction_Homo sapiens_hsa05031	0.47155930
90	Histidine metabolism_Homo sapiens_hsa00340	0.43822428
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.43612719
92	Cocaine addiction_Homo sapiens_hsa05030	0.43422537
93	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.42470657
94	Oocyte meiosis_Homo sapiens_hsa04114	0.40512210
95	Base excision repair_Homo sapiens_hsa03410	0.36490957
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.36352454
97	Lysine degradation_Homo sapiens_hsa00310	0.35286467
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34485409
99	Sphingolipid metabolism_Homo sapiens_hsa00600	0.31327626
100	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.30167214

PACRGL

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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