PACS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.84452055
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70258256
3antigen processing and presentation of endogenous antigen (GO:0019883)4.59643191
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45513455
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.15734164
6modulation by symbiont of host immune response (GO:0052553)4.15734164
7positive regulation by symbiont of host defense response (GO:0052509)4.15734164
8modulation by symbiont of host defense response (GO:0052031)4.15734164
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.15734164
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.15734164
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14891875
12negative regulation of cell killing (GO:0031342)4.14891875
13synaptic vesicle maturation (GO:0016188)3.90091773
14locomotory exploration behavior (GO:0035641)3.84770605
15leukocyte aggregation (GO:0070486)3.81455868
16regulation of B cell receptor signaling pathway (GO:0050855)3.81161053
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.59274664
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52361992
19layer formation in cerebral cortex (GO:0021819)3.50423447
20detection of bacterium (GO:0016045)3.48925603
21B cell receptor signaling pathway (GO:0050853)3.48180263
22detection of other organism (GO:0098543)3.48137180
23positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.47633385
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.39232615
25macrophage activation involved in immune response (GO:0002281)3.31735293
26G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.31060025
27synaptic vesicle docking involved in exocytosis (GO:0016081)3.25260295
28positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.16819971
29regulation of NFAT protein import into nucleus (GO:0051532)3.16082815
30germinal center formation (GO:0002467)3.12342522
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.12188132
32synaptic vesicle exocytosis (GO:0016079)3.10832161
33response to muramyl dipeptide (GO:0032495)3.09382319
34tolerance induction (GO:0002507)3.08680649
35vocalization behavior (GO:0071625)3.08266684
36regulation of synapse structural plasticity (GO:0051823)3.07839488
37response to laminar fluid shear stress (GO:0034616)3.06579516
38exploration behavior (GO:0035640)3.05497766
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.04965863
40regulation of ARF protein signal transduction (GO:0032012)3.03658770
41sodium ion export (GO:0071436)2.98035914
42mannose metabolic process (GO:0006013)2.95711143
43detection of external biotic stimulus (GO:0098581)2.95609955
44regulation of interferon-beta biosynthetic process (GO:0045357)2.95145746
45negative regulation of leukocyte mediated immunity (GO:0002704)2.93709061
46activation of protein kinase A activity (GO:0034199)2.92254434
47regulation of synaptic vesicle exocytosis (GO:2000300)2.91807246
48regulation of glutamate receptor signaling pathway (GO:1900449)2.91686516
49response to host (GO:0075136)2.90368854
50response to host defenses (GO:0052200)2.90368854
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.90368854
52cellular response to interleukin-15 (GO:0071350)2.90266949
53regulation of T-helper 2 cell differentiation (GO:0045628)2.89957246
54establishment of nucleus localization (GO:0040023)2.81484173
55response to peptidoglycan (GO:0032494)2.78649691
56regulation of ARF GTPase activity (GO:0032312)2.78599789
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77996967
58cellular extravasation (GO:0045123)2.77737757
59regulation of B cell differentiation (GO:0045577)2.77476013
60response to host immune response (GO:0052572)2.76668084
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76668084
62negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76450710
63negative regulation of phagocytosis (GO:0050765)2.75441086
64pre-miRNA processing (GO:0031054)2.75052873
65peptidyl-lysine dimethylation (GO:0018027)2.74505893
66negative regulation of T cell mediated immunity (GO:0002710)2.73948946
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.70733933
68clathrin coat assembly (GO:0048268)2.69719377
69neutrophil activation involved in immune response (GO:0002283)2.68256947
70response to type I interferon (GO:0034340)2.68214069
71cellular response to type I interferon (GO:0071357)2.65680418
72type I interferon signaling pathway (GO:0060337)2.65680418
73regulation of T cell tolerance induction (GO:0002664)2.65056281
74cytoskeletal anchoring at plasma membrane (GO:0007016)2.64799532
75detection of molecule of bacterial origin (GO:0032490)2.63636029
76positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.63029472
77NIK/NF-kappaB signaling (GO:0038061)2.62782081
78regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.60812832
79regulation of natural killer cell mediated immunity (GO:0002715)2.60812832
80glutamate secretion (GO:0014047)2.60212211
81regulation of extracellular matrix disassembly (GO:0010715)2.60036617
82positive regulation of B cell differentiation (GO:0045579)2.59523671
83modulation by symbiont of host cellular process (GO:0044068)2.58767570
84regulation of synaptic vesicle transport (GO:1902803)2.57554366
85T cell migration (GO:0072678)2.55329947
86cytoplasmic mRNA processing body assembly (GO:0033962)2.54247583
87positive regulation of Cdc42 GTPase activity (GO:0043089)2.53896120
88negative regulation of type 2 immune response (GO:0002829)2.53819717
89regulation of leukocyte degranulation (GO:0043300)2.52203331
90detection of biotic stimulus (GO:0009595)2.52096912
91regulation of gamma-delta T cell differentiation (GO:0045586)2.51761120
92regulation of clathrin-mediated endocytosis (GO:2000369)2.51086475
93positive regulation of Rap GTPase activity (GO:0032854)2.51044860
94regulation of dendritic cell antigen processing and presentation (GO:0002604)2.50988944
95cerebellar Purkinje cell differentiation (GO:0021702)2.50475135
96positive regulation of histone deacetylation (GO:0031065)2.50461268
97protein localization to synapse (GO:0035418)2.49563416
98protein localization to endosome (GO:0036010)2.48789788
99modulation by virus of host process (GO:0019054)2.48429765
100immunoglobulin mediated immune response (GO:0016064)2.47524539
101regulation of interleukin-12 biosynthetic process (GO:0045075)2.46039814
102regulation of long-term neuronal synaptic plasticity (GO:0048169)2.45511663
103positive regulation of gamma-delta T cell activation (GO:0046645)2.45227425
104negative regulation of T-helper cell differentiation (GO:0045623)2.44700441
105negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.44700441
106dendritic spine morphogenesis (GO:0060997)2.44699059
107regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43916139
108B cell homeostasis (GO:0001782)2.43909104
109antigen receptor-mediated signaling pathway (GO:0050851)2.43876324
110regulation of tolerance induction (GO:0002643)2.41619716
111peptidyl-threonine phosphorylation (GO:0018107)2.41415017
112signal complex assembly (GO:0007172)2.40755191
113regulation of Rap GTPase activity (GO:0032317)2.40719292
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.40208901
115regulation of macrophage cytokine production (GO:0010935)2.40083945
116regulation of mast cell degranulation (GO:0043304)2.39369097
117thymic T cell selection (GO:0045061)2.39250896
118positive regulation of lamellipodium assembly (GO:0010592)2.38914975
119proline transport (GO:0015824)2.38902879
120histone H3-K36 demethylation (GO:0070544)2.38252979
121regulation of myeloid leukocyte mediated immunity (GO:0002886)2.38085327
122activation of JUN kinase activity (GO:0007257)2.37965375
123negative regulation of microtubule polymerization (GO:0031115)2.37900177
124regulation of necroptotic process (GO:0060544)2.37733358
125T cell homeostasis (GO:0043029)2.37712088
126defense response to protozoan (GO:0042832)2.37588309
127negative regulation of interleukin-12 production (GO:0032695)2.36746748
128negative regulation of toll-like receptor signaling pathway (GO:0034122)2.36055093
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.35680240
130NLS-bearing protein import into nucleus (GO:0006607)2.34725553
131cell communication by electrical coupling (GO:0010644)2.34242138
132synaptic vesicle endocytosis (GO:0048488)2.32841134
133peptidyl-threonine modification (GO:0018210)2.32523890
134positive regulation of synapse maturation (GO:0090129)2.32027169
135glucocorticoid receptor signaling pathway (GO:0042921)2.30635490
136response to interleukin-15 (GO:0070672)2.30599802
137piRNA metabolic process (GO:0034587)2.28941766
138regulation of neuronal synaptic plasticity (GO:0048168)2.28661296
139negative thymic T cell selection (GO:0045060)2.27660209
140cellular potassium ion homeostasis (GO:0030007)2.26842195
141positive thymic T cell selection (GO:0045059)2.26474201
142negative T cell selection (GO:0043383)2.24931667
143positive T cell selection (GO:0043368)2.23649135
144T cell selection (GO:0045058)2.22562443
145antigen processing and presentation via MHC class Ib (GO:0002475)2.21520847
146neurotransmitter secretion (GO:0007269)2.19892805
147positive regulation of lamellipodium organization (GO:1902745)2.18843916
148vesicle transport along microtubule (GO:0047496)2.18753457
149synaptonemal complex assembly (GO:0007130)2.18537621
150mitotic sister chromatid cohesion (GO:0007064)2.17860047
151negative regulation of organelle assembly (GO:1902116)2.17731454
152ionotropic glutamate receptor signaling pathway (GO:0035235)2.17529718
153positive regulation of CREB transcription factor activity (GO:0032793)2.16549543
154intracellular estrogen receptor signaling pathway (GO:0030520)2.14874205
155sperm motility (GO:0030317)2.13836052
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.13729717
157neuron cell-cell adhesion (GO:0007158)2.13659764
158dopamine receptor signaling pathway (GO:0007212)2.13391483
159synaptonemal complex organization (GO:0070193)2.13367331
160regulation of gamma-delta T cell activation (GO:0046643)2.12429683
161* regulation of defense response to virus by virus (GO:0050690)2.12101736
162cell migration in hindbrain (GO:0021535)2.11800607
163negative regulation of erythrocyte differentiation (GO:0045647)2.11638749
164negative regulation of inclusion body assembly (GO:0090084)2.11441290
165positive regulation of dendrite morphogenesis (GO:0050775)2.11302091
166innervation (GO:0060384)2.10967476
167dendrite morphogenesis (GO:0048813)2.10317857
168cilium or flagellum-dependent cell motility (GO:0001539)2.08573062
169calcium ion-dependent exocytosis (GO:0017156)2.07883408
170regulation of glycogen (starch) synthase activity (GO:2000465)2.07780736
171stress fiber assembly (GO:0043149)2.07271480
172cerebellar Purkinje cell layer development (GO:0021680)2.07062817
173regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.06320602
174negative regulation of cell size (GO:0045792)2.02634346
175acrosome reaction (GO:0007340)2.02263730
176fusion of sperm to egg plasma membrane (GO:0007342)2.01847637
177glial cell proliferation (GO:0014009)2.01757800
178positive regulation of fibroblast migration (GO:0010763)2.01751828
179regulation of dendritic spine morphogenesis (GO:0061001)2.01629695
180positive regulation of vesicle fusion (GO:0031340)2.00827808

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.90614892
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.82913069
3MYC_22102868_ChIP-Seq_BL_Human2.79034202
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.75203862
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.73796163
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.53829712
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41489980
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.39544432
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37750871
10* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.36960337
11KDM2B_26808549_Chip-Seq_DND41_Human2.35178379
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.33901518
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.16118346
14DROSHA_22980978_ChIP-Seq_HELA_Human2.10305733
15KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.06878360
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01632313
17IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98604051
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97601369
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95452946
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.92098153
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.92036099
22KDM2B_26808549_Chip-Seq_JURKAT_Human1.88845885
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85279575
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84473504
25* RUNX1_22412390_ChIP-Seq_EML_Mouse1.84288702
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83810383
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79290288
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.79154326
29DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78812478
30* RACK7_27058665_Chip-Seq_MCF-7_Human1.78605762
31KDM2B_26808549_Chip-Seq_K562_Human1.76857177
32WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.76352846
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76135022
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.75234770
35MAF_26560356_Chip-Seq_TH2_Human1.72626246
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71815211
37REST_21632747_ChIP-Seq_MESCs_Mouse1.68951163
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66691787
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66355709
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.65168398
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.63931719
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.63419133
43VDR_21846776_ChIP-Seq_THP-1_Human1.63329444
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.62781451
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.57734067
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57319515
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.56242350
48IRF8_27001747_Chip-Seq_BMDM_Mouse1.55147986
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.50599633
50SPI1_23127762_ChIP-Seq_K562_Human1.48676912
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.48186449
52SCL_19346495_ChIP-Seq_HPC-7_Human1.46579550
53UTX_26944678_Chip-Seq_JUKART_Human1.41825617
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40704774
55LXR_22292898_ChIP-Seq_THP-1_Human1.39998081
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39348837
57JARID2_20064375_ChIP-Seq_MESCs_Mouse1.39142930
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.39023284
59MAF_26560356_Chip-Seq_TH1_Human1.38593653
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38317389
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.38042520
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37185209
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37055195
64RUNX_20019798_ChIP-Seq_JUKART_Human1.36569587
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35985837
66* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35765809
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34594633
68EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34154900
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33866547
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33277715
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32255102
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31341038
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25934667
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25883641
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25211859
76EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25211859
77* SA1_27219007_Chip-Seq_ERYTHROID_Human1.25146840
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25134912
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24493144
80SPI1_23547873_ChIP-Seq_NB4_Human1.21983900
81ZNF274_21170338_ChIP-Seq_K562_Hela1.21820350
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.21310264
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21067318
84P68_20966046_ChIP-Seq_HELA_Human1.19199420
85GATA1_19941826_ChIP-Seq_K562_Human1.19086163
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18732694
87* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17430362
88* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16974533
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.16754333
90ELK3_25401928_ChIP-Seq_HUVEC_Human1.16550887
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15467684
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15263105
93* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15216655
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.15199760
95GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14594484
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13727944
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13708185
98TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13291798
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11726881
100PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10735773
101NCOR1_26117541_ChIP-Seq_K562_Human1.10422779
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04982813
103* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04258505
104JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03153100
105AR_21572438_ChIP-Seq_LNCaP_Human1.03063230
106MYB_26560356_Chip-Seq_TH2_Human1.02906991
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02784582
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02558687
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02129082
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.01802952
111VDR_24763502_ChIP-Seq_THP-1_Human1.01727663
112SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.01306850
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.00919761
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00560722
115* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00108029
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.99794172
117BCOR_27268052_Chip-Seq_Bcells_Human0.99751031
118ELK4_26923725_Chip-Seq_MESODERM_Mouse0.99571139
119CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99161869
120* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98817410
121* SMC4_20622854_ChIP-Seq_HELA_Human0.98800095
122WDR5_24793694_ChIP-Seq_LNCAP_Human0.98498883
123SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98354730
124GATA1_19941827_ChIP-Seq_MEL_Mouse0.98257074
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97421001
126RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97153596
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96823133
128GATA1_26923725_Chip-Seq_HPCs_Mouse0.96689545
129LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95598023
130NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95411346
131AR_19668381_ChIP-Seq_PC3_Human0.95058366
132GATA3_27048872_Chip-Seq_THYMUS_Human0.94884155
133P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94812717
134GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94369371
135RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93574954
136GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93534129
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.93426595
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.92632677
139CREB1_26743006_Chip-Seq_LNCaP_Human0.90720995
140RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89959013
141MYB_26560356_Chip-Seq_TH1_Human0.89923958
142SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88419266
143YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87087347
144CIITA_25753668_ChIP-Seq_RAJI_Human0.86450699
145OCT4_19829295_ChIP-Seq_ESCs_Human0.85997619
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85572905
147* TET1_21490601_ChIP-Seq_MESCs_Mouse0.85189028
148* RUNX1_27514584_Chip-Seq_MCF-7_Human0.84413789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.68036064
2MP0003436_decreased_susceptibility_to3.66945341
3MP0003705_abnormal_hypodermis_morpholog2.86922438
4MP0000569_abnormal_digit_pigmentation2.76576122
5MP0003724_increased_susceptibility_to2.72513095
6MP0001835_abnormal_antigen_presentation2.72152438
7MP0003635_abnormal_synaptic_transmissio2.56793192
8MP0001790_abnormal_immune_system2.48606276
9MP0005387_immune_system_phenotype2.48606276
10MP0005000_abnormal_immune_tolerance2.29780799
11MP0005410_abnormal_fertilization2.22915986
12MP0004510_myositis2.19348323
13MP0002419_abnormal_innate_immunity2.15023722
14MP0005025_abnormal_response_to2.09881463
15MP0008260_abnormal_autophagy2.09118345
16MP0008961_abnormal_basal_metabolism2.08709441
17MP0002723_abnormal_immune_serum2.04498148
18MP0003787_abnormal_imprinting2.01172897
19MP0002452_abnormal_antigen_presenting1.97904604
20MP0002063_abnormal_learning/memory/cond1.97759242
21MP0005451_abnormal_body_composition1.97573041
22MP0004947_skin_inflammation1.96596946
23MP0005423_abnormal_somatic_nervous1.90909341
24MP0003566_abnormal_cell_adhesion1.89875261
25MP0003303_peritoneal_inflammation1.88380405
26MP0003279_aneurysm1.88157397
27MP0003122_maternal_imprinting1.87874716
28MP0003191_abnormal_cellular_cholesterol1.87139539
29MP0005464_abnormal_platelet_physiology1.85630154
30MP0001958_emphysema1.83135778
31MP0008877_abnormal_DNA_methylation1.82735731
32MP0001533_abnormal_skeleton_physiology1.77913505
33MP0008438_abnormal_cutaneous_collagen1.74948692
34MP0004808_abnormal_hematopoietic_stem1.71349077
35MP0002909_abnormal_adrenal_gland1.71310462
36MP0003880_abnormal_central_pattern1.67049540
37MP0002405_respiratory_system_inflammati1.66991292
38MP0005076_abnormal_cell_differentiation1.66468415
39MP0003300_gastrointestinal_ulcer1.62908459
40MP0005623_abnormal_meninges_morphology1.61230847
41MP0001873_stomach_inflammation1.58283925
42MP0004270_analgesia1.57605289
43MP0009333_abnormal_splenocyte_physiolog1.54008188
44MP0008569_lethality_at_weaning1.52864322
45MP0004381_abnormal_hair_follicle1.51645844
46MP0010155_abnormal_intestine_physiology1.51303912
47MP0003121_genomic_imprinting1.49384879
48MP0002396_abnormal_hematopoietic_system1.48999797
49MP0009278_abnormal_bone_marrow1.48555122
50MP0004811_abnormal_neuron_physiology1.46355424
51MP0000858_altered_metastatic_potential1.44280885
52MP0002572_abnormal_emotion/affect_behav1.42323094
53MP0003828_pulmonary_edema1.41918813
54MP0005058_abnormal_lysosome_morphology1.41650468
55MP0002998_abnormal_bone_remodeling1.41336962
56MP0003123_paternal_imprinting1.40937945
57MP0009745_abnormal_behavioral_response1.40705139
58MP0004858_abnormal_nervous_system1.40417221
59MP0003763_abnormal_thymus_physiology1.40144787
60MP0001851_eye_inflammation1.39127053
61MP0006082_CNS_inflammation1.35924984
62MP0009785_altered_susceptibility_to1.33916037
63MP0005409_darkened_coat_color1.31905044
64MP0005174_abnormal_tail_pigmentation1.31190093
65MP0002429_abnormal_blood_cell1.31153997
66MP0009780_abnormal_chondrocyte_physiolo1.30747254
67MP0000751_myopathy1.30631310
68MP0002933_joint_inflammation1.30356987
69MP0000689_abnormal_spleen_morphology1.27755963
70MP0004233_abnormal_muscle_weight1.26232389
71MP0002064_seizures1.25969472
72MP0002837_dystrophic_cardiac_calcinosis1.25701634
73MP0003183_abnormal_peptide_metabolism1.25382220
74MP0002148_abnormal_hypersensitivity_rea1.22871124
75MP0002166_altered_tumor_susceptibility1.20694422
76MP0003698_abnormal_male_reproductive1.19582299
77MP0001849_ear_inflammation1.16912822
78MP0001845_abnormal_inflammatory_respons1.16780987
79MP0000703_abnormal_thymus_morphology1.14537025
80MP0000465_gastrointestinal_hemorrhage1.13188375
81MP0003172_abnormal_lysosome_physiology1.11988244
82MP0000767_abnormal_smooth_muscle1.11125468
83MP0003879_abnormal_hair_cell1.10361042
84MP0003045_fibrosis1.07869703
85MP0002184_abnormal_innervation1.07648052
86MP0005390_skeleton_phenotype1.07066134
87MP0001968_abnormal_touch/_nociception1.06385199
88MP0002398_abnormal_bone_marrow1.05844187
89MP0002089_abnormal_postnatal_growth/wei1.05491666
90MP0002877_abnormal_melanocyte_morpholog1.03579820
91MP0002132_abnormal_respiratory_system1.00990844
92MP0005023_abnormal_wound_healing1.00360786
93MP0002557_abnormal_social/conspecific_i0.98662663
94MP0009046_muscle_twitch0.97588417
95MP0001348_abnormal_lacrimal_gland0.97064511
96MP0005397_hematopoietic_system_phenotyp0.96660702
97MP0001545_abnormal_hematopoietic_system0.96660702
98MP0000778_abnormal_nervous_system0.96612230
99MP0002653_abnormal_ependyma_morphology0.94131607
100MP0004883_abnormal_blood_vessel0.94088681
101MP0001929_abnormal_gametogenesis0.94041224
102MP0003453_abnormal_keratinocyte_physiol0.93995289
103MP0002234_abnormal_pharynx_morphology0.92892482
104MP0001501_abnormal_sleep_pattern0.89909335
105MP0004084_abnormal_cardiac_muscle0.89346220
106MP0000955_abnormal_spinal_cord0.88205965
107MP0008770_decreased_survivor_rate0.87986693
108MP0002152_abnormal_brain_morphology0.87886734
109MP0005671_abnormal_response_to0.87555020
110MP0004185_abnormal_adipocyte_glucose0.85814303
111MP0005187_abnormal_penis_morphology0.85034244
112MP0002733_abnormal_thermal_nociception0.83519415
113MP0010352_gastrointestinal_tract_polyps0.83148135
114MP0000685_abnormal_immune_system0.82911713
115MP0008469_abnormal_protein_level0.82638088
116MP0003448_altered_tumor_morphology0.82553326
117MP0000678_abnormal_parathyroid_gland0.82408588
118MP0000249_abnormal_blood_vessel0.81631147
119MP0008874_decreased_physiological_sensi0.81147053
120MP0003075_altered_response_to0.81038895
121MP0009840_abnormal_foam_cell0.80404520
122MP0004085_abnormal_heartbeat0.78082283
123MP0000534_abnormal_ureter_morphology0.78006904
124MP0005310_abnormal_salivary_gland0.77812746
125MP0002925_abnormal_cardiovascular_devel0.77394301
126MP0003795_abnormal_bone_structure0.76981952
127MP0003091_abnormal_cell_migration0.76922754
128MP0003866_abnormal_defecation0.76900519
129MP0001486_abnormal_startle_reflex0.76464679
130MP0005275_abnormal_skin_tensile0.76139780
131MP0002734_abnormal_mechanical_nocicepti0.75960945
132MP0005621_abnormal_cell_physiology0.75764869
133MP0005666_abnormal_adipose_tissue0.75515801
134MP0005645_abnormal_hypothalamus_physiol0.75465359
135MP0003861_abnormal_nervous_system0.75319747
136MP0004484_altered_response_of0.75256911
137MP0003646_muscle_fatigue0.75098660
138MP0001970_abnormal_pain_threshold0.74893410
139MP0005386_behavior/neurological_phenoty0.74570755
140MP0004924_abnormal_behavior0.74570755
141MP0008004_abnormal_stomach_pH0.74516856
142MP0005375_adipose_tissue_phenotype0.74313622
143MP0010630_abnormal_cardiac_muscle0.74008196
144MP0005164_abnormal_response_to0.73711476
145MP0000604_amyloidosis0.73675364
146MP0002882_abnormal_neuron_morphology0.72137111
147MP0003329_amyloid_beta_deposits0.72133647
148MP0003115_abnormal_respiratory_system0.71750614
149MP0002420_abnormal_adaptive_immunity0.69996235
150MP0002272_abnormal_nervous_system0.69310028
151MP0004885_abnormal_endolymph0.68405109
152MP0001663_abnormal_digestive_system0.68234557
153MP0003690_abnormal_glial_cell0.67951283
154MP0001819_abnormal_immune_cell0.67860625
155MP0004130_abnormal_muscle_cell0.67120564
156MP0004087_abnormal_muscle_fiber0.66790513
157MP0000716_abnormal_immune_system0.65691910
158MP0002009_preneoplasia0.65065646
159MP0010234_abnormal_vibrissa_follicle0.64943516
160MP0005166_decreased_susceptibility_to0.64189687
161MP0000733_abnormal_muscle_development0.64085507
162MP0002161_abnormal_fertility/fecundity0.63744551
163MP0000266_abnormal_heart_morphology0.63705477
164MP0001800_abnormal_humoral_immune0.63038285
165MP0002006_tumorigenesis0.62168056
166MP0002210_abnormal_sex_determination0.62059792
167MP0000015_abnormal_ear_pigmentation0.61839013
168MP0004215_abnormal_myocardial_fiber0.61318926
169MP0002067_abnormal_sensory_capabilities0.60625602
170MP0002722_abnormal_immune_system0.60095973

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.48149826
2Visual hallucinations (HP:0002367)3.30082589
3Cellulitis (HP:0100658)3.22078252
4Myositis (HP:0100614)3.14825017
5Recurrent abscess formation (HP:0002722)3.12311505
6Abnormality of macrophages (HP:0004311)3.09658073
7Recurrent bacterial skin infections (HP:0005406)3.05338833
8Hyperacusis (HP:0010780)3.04081442
9Increased IgE level (HP:0003212)2.99020337
10Amyotrophic lateral sclerosis (HP:0007354)2.86319708
11Nasal polyposis (HP:0100582)2.85538435
12Papilledema (HP:0001085)2.84645836
13Spontaneous hematomas (HP:0007420)2.81446975
14Orchitis (HP:0100796)2.79391166
15Protrusio acetabuli (HP:0003179)2.77840865
16Peritonitis (HP:0002586)2.75489566
17Meningitis (HP:0001287)2.74364889
18Broad face (HP:0000283)2.70729574
19Elevated erythrocyte sedimentation rate (HP:0003565)2.66595126
20Short 4th metacarpal (HP:0010044)2.64821068
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.64821068
22Macroorchidism (HP:0000053)2.64119302
23Recurrent fungal infections (HP:0002841)2.62383727
24Gastrointestinal infarctions (HP:0005244)2.60978607
25Prolonged bleeding time (HP:0003010)2.59416093
26Abnormality of the nasal mucosa (HP:0000433)2.54418015
27Genetic anticipation (HP:0003743)2.50769431
28Gastrointestinal stroma tumor (HP:0100723)2.49877887
29Gastrointestinal inflammation (HP:0004386)2.49050866
30Mediastinal lymphadenopathy (HP:0100721)2.46973885
31Focal seizures (HP:0007359)2.44951511
32Gingivitis (HP:0000230)2.43676381
33Pointed chin (HP:0000307)2.43656209
34Absent/shortened dynein arms (HP:0200106)2.39009295
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.39009295
36Insomnia (HP:0100785)2.38599405
37Colitis (HP:0002583)2.38012846
38Vasculitis (HP:0002633)2.37726305
39Abnormality of the lower motor neuron (HP:0002366)2.37643243
40Emphysema (HP:0002097)2.37116546
41Dilatation of the ascending aorta (HP:0005111)2.35668517
42Neoplasm of the heart (HP:0100544)2.34676464
43Chronic obstructive pulmonary disease (HP:0006510)2.34137151
44Obstructive lung disease (HP:0006536)2.34137151
45Recurrent gram-negative bacterial infections (HP:0005420)2.33459697
46Inflammation of the large intestine (HP:0002037)2.33306033
47Agammaglobulinemia (HP:0004432)2.32342645
48Retrobulbar optic neuritis (HP:0100654)2.32307879
49Optic neuritis (HP:0100653)2.32307879
50Mutism (HP:0002300)2.30050311
51Myokymia (HP:0002411)2.25644630
52Abnormality of the fingertips (HP:0001211)2.25293688
53Recurrent viral infections (HP:0004429)2.22232006
54Spondylolisthesis (HP:0003302)2.21854600
55Chest pain (HP:0100749)2.21164898
56Dysmetric saccades (HP:0000641)2.20208993
57Pustule (HP:0200039)2.19394700
58Impaired smooth pursuit (HP:0007772)2.16057208
59Heterotopia (HP:0002282)2.16001919
60Cerebral aneurysm (HP:0004944)2.15811113
61Chronic mucocutaneous candidiasis (HP:0002728)2.13595762
62Recurrent cutaneous fungal infections (HP:0011370)2.13595762
63Recurrent skin infections (HP:0001581)2.12879412
64Epistaxis (HP:0000421)2.11333337
65Supranuclear gaze palsy (HP:0000605)2.09372410
66Panhypogammaglobulinemia (HP:0003139)2.09132170
67Elfin facies (HP:0004428)2.08895813
68Increased variability in muscle fiber diameter (HP:0003557)2.07685395
69Premature rupture of membranes (HP:0001788)2.07608792
70Increased connective tissue (HP:0009025)2.05727717
71Vascular tortuosity (HP:0004948)2.05365789
72Verrucae (HP:0200043)2.04793646
73Papilloma (HP:0012740)2.04793646
74Aneurysm (HP:0002617)2.04507970
75Disproportionate tall stature (HP:0001519)2.03932106
76Stomatitis (HP:0010280)2.03759384
77Hemiplegia (HP:0002301)2.03499570
78Depression (HP:0000716)2.03029211
79Sacral dimple (HP:0000960)2.02785455
80Progressive cerebellar ataxia (HP:0002073)2.02648082
81Slow saccadic eye movements (HP:0000514)2.02604262
82Renal duplication (HP:0000075)2.02448686
83Broad palm (HP:0001169)2.02388801
84Frequent falls (HP:0002359)2.01347484
85Abnormality of ocular smooth pursuit (HP:0000617)2.01309855
86Trigonocephaly (HP:0000243)2.01004343
87Cervical subluxation (HP:0003308)1.99741038
88Recurrent bronchitis (HP:0002837)1.97012847
89Abnormality of the peritoneum (HP:0002585)1.96765705
90Abnormality of oral frenula (HP:0000190)1.96725380
91T lymphocytopenia (HP:0005403)1.95975411
92Abnormality of the 4th metacarpal (HP:0010012)1.94698383
93Urinary urgency (HP:0000012)1.94220539
94Mitral regurgitation (HP:0001653)1.93471205
95Lymphopenia (HP:0001888)1.93195257
96Aortic dissection (HP:0002647)1.93187398
97Narrow palate (HP:0000189)1.93127858
98Urticaria (HP:0001025)1.92263460
99Focal motor seizures (HP:0011153)1.91865344
100Abnormal platelet volume (HP:0011876)1.91070241
101Dislocated radial head (HP:0003083)1.89772411
102Thin bony cortex (HP:0002753)1.88429305
103Encephalitis (HP:0002383)1.87713016
104Abnormality of skeletal muscle fiber size (HP:0012084)1.87202741
105Urinary bladder sphincter dysfunction (HP:0002839)1.86727284
106Spinal cord lesions (HP:0100561)1.86355922
107Syringomyelia (HP:0003396)1.86355922
108Striae distensae (HP:0001065)1.86353614
109Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86122054
110Shallow orbits (HP:0000586)1.85642901
111Gingival bleeding (HP:0000225)1.85347819
112Abnormality of binocular vision (HP:0011514)1.85041059
113Diplopia (HP:0000651)1.85041059
114Obsessive-compulsive behavior (HP:0000722)1.84835369
115Viral hepatitis (HP:0006562)1.84403327
116Inappropriate behavior (HP:0000719)1.83960253
117Segmental peripheral demyelination/remyelination (HP:0003481)1.83551991
118Restrictive lung disease (HP:0002091)1.83458952
119Pulmonary infiltrates (HP:0002113)1.82973769
120Distal lower limb amyotrophy (HP:0008944)1.82905419
121Apathy (HP:0000741)1.82766127
122Osteomyelitis (HP:0002754)1.82172949
123Abnormality of cells of the lymphoid lineage (HP:0012140)1.81566866
124Increased density of long bones (HP:0006392)1.81499371
125Mitral valve prolapse (HP:0001634)1.79783412
126Absent frontal sinuses (HP:0002688)1.79312093
127Ankyloglossia (HP:0010296)1.78880611
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.78151664
129Metaphyseal cupping (HP:0003021)1.78058201
130Genu recurvatum (HP:0002816)1.77858792
131Subacute progressive viral hepatitis (HP:0006572)1.77660985
132Renovascular hypertension (HP:0100817)1.77483904
133Abnormality of the radial head (HP:0003995)1.77327593
134Long palpebral fissure (HP:0000637)1.76777145
135Abnormality of T cell number (HP:0011839)1.76600866
136Truncal obesity (HP:0001956)1.74315276
137Volvulus (HP:0002580)1.74164777
138Blue sclerae (HP:0000592)1.73559916
139Truncal ataxia (HP:0002078)1.71825735
140Distal lower limb muscle weakness (HP:0009053)1.71818692
141Impaired vibration sensation in the lower limbs (HP:0002166)1.71621293
142Hypochromic anemia (HP:0001931)1.71219186
143Increased nuchal translucency (HP:0010880)1.70539581
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70262090
145Dysostosis multiplex (HP:0000943)1.69971896
146Abnormality of the astrocytes (HP:0100707)1.69866926
147Astrocytoma (HP:0009592)1.69866926
148Vertebral compression fractures (HP:0002953)1.69733110
149Ankle clonus (HP:0011448)1.69085545
150Enlarged penis (HP:0000040)1.69063205
151Sepsis (HP:0100806)1.68853759
152Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.68260121
153Bowel diverticulosis (HP:0005222)1.67556701
154Arterial thrombosis (HP:0004420)1.67148398
155Fragile skin (HP:0001030)1.66847415
156Diminished motivation (HP:0000745)1.66311271
157Arterial tortuosity (HP:0005116)1.65881356
158Overriding aorta (HP:0002623)1.65029415
159Postural instability (HP:0002172)1.64717273
160Infertility (HP:0000789)1.64193613
161Stereotypic behavior (HP:0000733)1.63964341
162Spinal canal stenosis (HP:0003416)1.63784725
163Aortic aneurysm (HP:0004942)1.63763496
164Hypercortisolism (HP:0001578)1.63192738
165Epileptic encephalopathy (HP:0200134)1.62956317
166Obstructive sleep apnea (HP:0002870)1.61330460
167Abnormal delayed hypersensitivity skin test (HP:0002963)1.61169431
168Long toe (HP:0010511)1.59842419
169Bronchitis (HP:0012387)1.59364746
170Papillary thyroid carcinoma (HP:0002895)1.59321849
171Open mouth (HP:0000194)1.58916252
172Bicuspid aortic valve (HP:0001647)1.58107263
173Fatigue (HP:0012378)1.58071706
174Flat cornea (HP:0007720)1.57821060
175Deep palmar crease (HP:0006191)1.55521691
176Lower limb amyotrophy (HP:0007210)1.55475769
177Hemiparesis (HP:0001269)1.54975027
178Annular pancreas (HP:0001734)1.54738899
179Hand muscle atrophy (HP:0009130)1.53661798
180Megalocornea (HP:0000485)1.53610522
181Intellectual disability, profound (HP:0002187)1.52066430
182Rapidly progressive (HP:0003678)1.51746568
183Urethral obstruction (HP:0000796)1.51113637
184Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.48142708
185Thick eyebrow (HP:0000574)1.47961914
186Asymmetric septal hypertrophy (HP:0001670)1.47872938
187Gaze-evoked nystagmus (HP:0000640)1.46574933
188Long eyelashes (HP:0000527)1.43910563
189Basal cell carcinoma (HP:0002671)1.43635148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD33.68783632
2PRPF4B3.48364342
3EEF2K3.34863437
4MAP3K93.22215863
5TRIB32.87291297
6MARK12.51598979
7TAOK12.32668560
8SIK12.32232943
9MAP3K42.27133937
10SIK22.21042396
11PKN22.16959887
12NTRK32.15384271
13SMG12.12840361
14MAP4K12.05611788
15PAK62.01522381
16EPHB11.99654678
17KSR21.92073022
18ICK1.88130896
19TYK21.85619428
20MAP2K31.81408035
21CAMK1G1.73353797
22MAP3K101.72742184
23CDK121.70251274
24IRAK41.68658763
25NTRK21.63669465
26FGFR41.60864751
27MINK11.56605106
28CAMKK11.51827767
29BLK1.50837490
30EPHA41.49961808
31DMPK1.46713312
32TYRO31.45335445
33CSK1.44910394
34STK381.40667408
35PRKCH1.37625069
36BTK1.37299807
37KSR11.34221142
38RIPK11.33640438
39MARK21.33094447
40RET1.32209182
41ALK1.29422550
42MAP3K31.26344932
43DAPK21.17590232
44PDK41.12985437
45PDK31.12985437
46MAP3K141.11317933
47PTK2B1.10824064
48MAP2K71.09346977
49TESK11.08658723
50TBK11.05531133
51DAPK11.01903872
52MAP3K111.00857114
53FES1.00459953
54MAP2K41.00007557
55LATS20.98997025
56MAP3K120.98880906
57IKBKE0.91589014
58CAMK1D0.89852730
59CSF1R0.89459178
60STK110.88975620
61TAOK20.86706893
62CDK50.86617180
63SCYL20.86078120
64RIPK40.85497919
65SIK30.85248005
66PDK10.81228094
67MAP3K60.80678405
68MAPK70.79980592
69RPS6KA20.78292038
70MAP3K70.76639547
71LCK0.76372686
72PTK60.76266869
73PNCK0.75128587
74TTN0.74663833
75PRKD20.74053608
76RAF10.72546476
77MAP3K10.72180408
78MAPK130.71803557
79FGFR30.71798705
80HCK0.71703494
81GRK60.71499111
82IRAK30.70898493
83TESK20.69617428
84TAOK30.68443641
85CAMK10.67041737
86SGK30.66981261
87PHKG10.66814020
88PHKG20.66814020
89MTOR0.65882288
90ZAP700.64477076
91JAK10.63794373
92TNK20.63369898
93PDGFRA0.63050565
94RPS6KL10.61734537
95RPS6KC10.61734537
96JAK30.60765949
97UHMK10.59504608
98LYN0.59146118
99HIPK20.56246614
100SYK0.55999142
101FGR0.55480871
102MAPK110.55275044
103MAP3K20.53100284
104LRRK20.52991473
105TXK0.52913692
106CDC42BPA0.52359739
107LMTK20.52305287
108MARK30.51422197
109IRAK20.51150517
110MAP2K20.50213719
111CDK190.50100819
112KIT0.48966834
113ITK0.47025688
114MAP3K130.45606650
115PDGFRB0.45375892
116RPS6KA60.45184389
117WNK10.44817701
118DYRK1B0.44075671
119TRPM70.43880141
120MELK0.43827746
121PRKD10.43500199
122NEK20.42975341
123CDK40.42924001
124PAK30.42528735
125IKBKB0.41982941
126PAK20.41859222
127NEK90.40589038
128MAPK80.40452656
129NTRK10.40067771
130BMX0.39910517
131ERN10.39613029
132MAPKAPK20.39402674
133JAK20.38690868
134CDK180.38240214
135FYN0.37576710
136TGFBR20.36781606
137CDK150.36753551
138MAPK120.36519037
139CDK11A0.36179747
140CAMK40.36178104
141PDPK10.35425961
142STK100.35292769
143SGK20.34810937

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047201.79453777
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53020780
3Circadian entrainment_Homo sapiens_hsa047131.49997733
4Olfactory transduction_Homo sapiens_hsa047401.48160969
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44883306
6Amphetamine addiction_Homo sapiens_hsa050311.43073543
7Allograft rejection_Homo sapiens_hsa053301.40552394
8Synaptic vesicle cycle_Homo sapiens_hsa047211.39776419
9Neurotrophin signaling pathway_Homo sapiens_hsa047221.38581667
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38490732
11Dopaminergic synapse_Homo sapiens_hsa047281.37770370
12VEGF signaling pathway_Homo sapiens_hsa043701.34501908
13Autoimmune thyroid disease_Homo sapiens_hsa053201.34253696
14Graft-versus-host disease_Homo sapiens_hsa053321.34009759
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33702863
16Estrogen signaling pathway_Homo sapiens_hsa049151.32755790
17Measles_Homo sapiens_hsa051621.31284878
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31246377
19Glioma_Homo sapiens_hsa052141.31019427
20Dorso-ventral axis formation_Homo sapiens_hsa043201.30253192
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.30069798
22Nicotine addiction_Homo sapiens_hsa050331.29021909
23B cell receptor signaling pathway_Homo sapiens_hsa046621.28561911
24Morphine addiction_Homo sapiens_hsa050321.28179066
25Colorectal cancer_Homo sapiens_hsa052101.26825649
26Tuberculosis_Homo sapiens_hsa051521.26259258
27T cell receptor signaling pathway_Homo sapiens_hsa046601.25262910
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24801024
29Type II diabetes mellitus_Homo sapiens_hsa049301.24303912
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.23899296
31Renin secretion_Homo sapiens_hsa049241.23835740
32Oxytocin signaling pathway_Homo sapiens_hsa049211.23787051
33Cholinergic synapse_Homo sapiens_hsa047251.23579664
34Other glycan degradation_Homo sapiens_hsa005111.21750110
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.21694359
36Insulin secretion_Homo sapiens_hsa049111.20275950
37Chronic myeloid leukemia_Homo sapiens_hsa052201.19531287
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19360379
39Staphylococcus aureus infection_Homo sapiens_hsa051501.18537189
40Glutamatergic synapse_Homo sapiens_hsa047241.17711883
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17484833
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17100547
43Endometrial cancer_Homo sapiens_hsa052131.16790947
44Influenza A_Homo sapiens_hsa051641.16562828
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16282866
46mTOR signaling pathway_Homo sapiens_hsa041501.16251111
47Gastric acid secretion_Homo sapiens_hsa049711.14643813
48Salivary secretion_Homo sapiens_hsa049701.14285811
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13412716
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12957842
51GnRH signaling pathway_Homo sapiens_hsa049121.11854017
52Non-small cell lung cancer_Homo sapiens_hsa052231.11246817
53TNF signaling pathway_Homo sapiens_hsa046681.11158396
54Malaria_Homo sapiens_hsa051441.10735692
55Cocaine addiction_Homo sapiens_hsa050301.06911597
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06395304
57Renal cell carcinoma_Homo sapiens_hsa052111.04918427
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04765833
59Hepatitis C_Homo sapiens_hsa051601.04514178
60ErbB signaling pathway_Homo sapiens_hsa040121.04442643
61Prolactin signaling pathway_Homo sapiens_hsa049171.03816328
62GABAergic synapse_Homo sapiens_hsa047271.03431161
63Acute myeloid leukemia_Homo sapiens_hsa052211.03341475
64Oocyte meiosis_Homo sapiens_hsa041141.02113485
65Pancreatic cancer_Homo sapiens_hsa052121.01842045
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.01659382
67Osteoclast differentiation_Homo sapiens_hsa043801.01576648
68Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01328812
69Hematopoietic cell lineage_Homo sapiens_hsa046400.99001960
70cAMP signaling pathway_Homo sapiens_hsa040240.98570876
71Gap junction_Homo sapiens_hsa045400.98103002
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96793863
73Inositol phosphate metabolism_Homo sapiens_hsa005620.96330104
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96004957
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95288945
76MAPK signaling pathway_Homo sapiens_hsa040100.93227934
77Herpes simplex infection_Homo sapiens_hsa051680.92315169
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92104883
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.91879268
80Dilated cardiomyopathy_Homo sapiens_hsa054140.91671172
81Viral myocarditis_Homo sapiens_hsa054160.91457463
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90782789
83Platelet activation_Homo sapiens_hsa046110.89418005
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.89086390
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88477967
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88234222
87Amoebiasis_Homo sapiens_hsa051460.87909073
88Long-term depression_Homo sapiens_hsa047300.87776533
89Calcium signaling pathway_Homo sapiens_hsa040200.87710887
90Axon guidance_Homo sapiens_hsa043600.87084194
91Apoptosis_Homo sapiens_hsa042100.86927951
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86249873
93Antigen processing and presentation_Homo sapiens_hsa046120.85280232
94Type I diabetes mellitus_Homo sapiens_hsa049400.84742147
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84330629
96Chemokine signaling pathway_Homo sapiens_hsa040620.84172948
97Thyroid cancer_Homo sapiens_hsa052160.84023017
98Melanogenesis_Homo sapiens_hsa049160.83919358
99Endocytosis_Homo sapiens_hsa041440.82307116
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.82221758
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82201630
102Prostate cancer_Homo sapiens_hsa052150.81816950
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81657732
104Glucagon signaling pathway_Homo sapiens_hsa049220.81554369
105Insulin signaling pathway_Homo sapiens_hsa049100.78771621
106Toxoplasmosis_Homo sapiens_hsa051450.78438295
107Shigellosis_Homo sapiens_hsa051310.78078203
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.77425017
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77388579
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.77358439
111FoxO signaling pathway_Homo sapiens_hsa040680.77186476
112Rap1 signaling pathway_Homo sapiens_hsa040150.76714755
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75961117
114Choline metabolism in cancer_Homo sapiens_hsa052310.74725938
115Hepatitis B_Homo sapiens_hsa051610.73638137
116Small cell lung cancer_Homo sapiens_hsa052220.73270770
117Taste transduction_Homo sapiens_hsa047420.72843658
118Wnt signaling pathway_Homo sapiens_hsa043100.72359275
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72314591
120Serotonergic synapse_Homo sapiens_hsa047260.70965556
121Focal adhesion_Homo sapiens_hsa045100.70585729
122Adherens junction_Homo sapiens_hsa045200.70313820
123Leishmaniasis_Homo sapiens_hsa051400.68119829
124Proteoglycans in cancer_Homo sapiens_hsa052050.67829296
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.67618015
126HIF-1 signaling pathway_Homo sapiens_hsa040660.67294885
127Phagosome_Homo sapiens_hsa041450.66822997
128HTLV-I infection_Homo sapiens_hsa051660.66105450
129Primary immunodeficiency_Homo sapiens_hsa053400.64603965
130Notch signaling pathway_Homo sapiens_hsa043300.64329645
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64241012
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63887739
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.63714284
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63348714
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.63015378
136Viral carcinogenesis_Homo sapiens_hsa052030.62380717
137Insulin resistance_Homo sapiens_hsa049310.61733125
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61350408
139African trypanosomiasis_Homo sapiens_hsa051430.59914326
140Bladder cancer_Homo sapiens_hsa052190.59516283
141Salmonella infection_Homo sapiens_hsa051320.59326148

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