PACSIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.83401272
2regulation of integrin activation (GO:0033623)5.04792670
3positive regulation by symbiont of host defense response (GO:0052509)4.58745733
4modulation by symbiont of host defense response (GO:0052031)4.58745733
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58745733
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58745733
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.58745733
8modulation by symbiont of host immune response (GO:0052553)4.58745733
9embryonic process involved in female pregnancy (GO:0060136)4.56938720
10proline metabolic process (GO:0006560)4.24344870
11transcription from mitochondrial promoter (GO:0006390)4.06681680
12negative regulation of cell killing (GO:0031342)3.99590647
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99590647
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.94934123
15negative regulation of fatty acid biosynthetic process (GO:0045717)3.85480010
16detection of molecule of bacterial origin (GO:0032490)3.84378941
17regulation of hippo signaling (GO:0035330)3.84088016
18neutrophil activation involved in immune response (GO:0002283)3.83917918
19sarcomere organization (GO:0045214)3.83114565
20regulation of translational fidelity (GO:0006450)3.82205205
21response to peptidoglycan (GO:0032494)3.82031513
22establishment of apical/basal cell polarity (GO:0035089)3.81489879
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.78747144
24macrophage activation involved in immune response (GO:0002281)3.71727155
25negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.71009636
26mitotic G1 DNA damage checkpoint (GO:0031571)3.66590592
27plasma membrane repair (GO:0001778)3.63962049
28negative regulation of erythrocyte differentiation (GO:0045647)3.61203811
29positive regulation of gamma-delta T cell activation (GO:0046645)3.61084816
30apoptotic process involved in morphogenesis (GO:0060561)3.60852460
31embryonic placenta development (GO:0001892)3.58076472
32antigen processing and presentation of endogenous antigen (GO:0019883)3.53613043
33detection of other organism (GO:0098543)3.52817477
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46593467
35regulation of tight junction assembly (GO:2000810)3.44111313
36detection of external biotic stimulus (GO:0098581)3.41001709
37carnitine shuttle (GO:0006853)3.40832323
38cardiac myofibril assembly (GO:0055003)3.37740150
39epithelial cell-cell adhesion (GO:0090136)3.33931232
40lysine metabolic process (GO:0006553)3.29295347
41lysine catabolic process (GO:0006554)3.29295347
42detection of bacterium (GO:0016045)3.26022104
43apoptotic cell clearance (GO:0043277)3.20639787
44bundle of His cell to Purkinje myocyte communication (GO:0086069)3.20107094
45positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.19143545
46fatty acid transmembrane transport (GO:1902001)3.18424338
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14436991
48response to host (GO:0075136)3.14436991
49response to host defenses (GO:0052200)3.14436991
50positive regulation of Cdc42 GTPase activity (GO:0043089)3.14332036
51barbed-end actin filament capping (GO:0051016)3.11027394
52regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.10004583
53regulation of leukocyte degranulation (GO:0043300)3.09937703
54mitotic G1/S transition checkpoint (GO:0044819)3.09690753
55cardiac muscle cell development (GO:0055013)3.09050378
56response to host immune response (GO:0052572)3.06717149
57response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.06717149
58cellular extravasation (GO:0045123)3.06082313
59negative regulation of interleukin-12 production (GO:0032695)3.04386398
60regulation of interferon-beta biosynthetic process (GO:0045357)3.04250919
61positive regulation of cellular amide metabolic process (GO:0034250)3.03137563
62stress fiber assembly (GO:0043149)3.01295951
63positive regulation of protein homooligomerization (GO:0032464)3.00698312
64mitochondrial DNA metabolic process (GO:0032042)3.00466960
65pinocytosis (GO:0006907)3.00454251
66response to muramyl dipeptide (GO:0032495)2.98929472
67hypotonic response (GO:0006971)2.98574369
68establishment of monopolar cell polarity (GO:0061162)2.98563592
69establishment or maintenance of monopolar cell polarity (GO:0061339)2.98563592
70regulation of mast cell degranulation (GO:0043304)2.97784773
71tricarboxylic acid cycle (GO:0006099)2.97770053
72detection of biotic stimulus (GO:0009595)2.97356203
73regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96197274
74regulation of cholesterol homeostasis (GO:2000188)2.93647261
75regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.93525315
764-hydroxyproline metabolic process (GO:0019471)2.91062542
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.91009269
78cardiac cell development (GO:0055006)2.90135221
79peptidyl-proline hydroxylation (GO:0019511)2.89701299
80lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88783965
81negative regulation of fatty acid metabolic process (GO:0045922)2.87028835
82negative regulation of potassium ion transmembrane transport (GO:1901380)2.86945838
83G1 DNA damage checkpoint (GO:0044783)2.86761650
84regulation of protein homooligomerization (GO:0032462)2.86234551
85protein hydroxylation (GO:0018126)2.83684005
86embryonic camera-type eye development (GO:0031076)2.80883899
87sulfur amino acid catabolic process (GO:0000098)2.80856468
88response to laminar fluid shear stress (GO:0034616)2.80290702
89COPI coating of Golgi vesicle (GO:0048205)2.79441483
90Golgi transport vesicle coating (GO:0048200)2.79441483
91germinal center formation (GO:0002467)2.77946571
92positive regulation of receptor recycling (GO:0001921)2.77921035
93replication fork processing (GO:0031297)2.77134835
94trophectodermal cell differentiation (GO:0001829)2.76494908
95cell-substrate junction assembly (GO:0007044)2.76128236
96positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.75181809
97regulation of integrin-mediated signaling pathway (GO:2001044)2.74265870
98antigen processing and presentation via MHC class Ib (GO:0002475)2.73366669
99regulation of gamma-delta T cell activation (GO:0046643)2.72045124
100regulation of early endosome to late endosome transport (GO:2000641)2.70280342
101positive regulation of protein oligomerization (GO:0032461)2.68970623
1022-oxoglutarate metabolic process (GO:0006103)2.67844601
103macrophage activation (GO:0042116)2.67261345
104cellular response to thyroid hormone stimulus (GO:0097067)2.66673288
105neutrophil activation (GO:0042119)2.66459769
106* protein localization to endosome (GO:0036010)2.66417812
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65742204
108cellular response to zinc ion (GO:0071294)2.65540007
109actomyosin structure organization (GO:0031032)2.64236272
110negative regulation of toll-like receptor signaling pathway (GO:0034122)2.63995454
111regulation of T-helper 2 cell differentiation (GO:0045628)2.63121055
112immunoglobulin mediated immune response (GO:0016064)2.63084171
113myofibril assembly (GO:0030239)2.61230187
114regulation of mast cell activation involved in immune response (GO:0033006)2.60936569
115oxidative demethylation (GO:0070989)2.60828329
116basement membrane organization (GO:0071711)2.60647923
117respiratory burst (GO:0045730)2.60386503
118protein retention in ER lumen (GO:0006621)2.60121570
119amino-acid betaine transport (GO:0015838)2.59429354
120carnitine transport (GO:0015879)2.59429354
121mannose metabolic process (GO:0006013)2.59389219
122granulocyte activation (GO:0036230)2.58972189
123regulation of B cell receptor signaling pathway (GO:0050855)2.58667663
124adherens junction assembly (GO:0034333)2.56521303
125fibroblast migration (GO:0010761)2.56285518
126regulation of necroptotic process (GO:0060544)2.55611014
127carnitine transmembrane transport (GO:1902603)2.55126409
128actin-myosin filament sliding (GO:0033275)2.54573366
129muscle filament sliding (GO:0030049)2.54573366
130positive regulation of SMAD protein import into nucleus (GO:0060391)2.54167474
131maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53306782
132maternal placenta development (GO:0001893)2.53065931
133positive regulation of leukocyte degranulation (GO:0043302)2.52851855
134regulation of macrophage cytokine production (GO:0010935)2.51640448
135regulation of sister chromatid cohesion (GO:0007063)2.50816504
136glutamine family amino acid biosynthetic process (GO:0009084)2.48269115
137regulation of regulated secretory pathway (GO:1903305)2.47881575
138apoptotic process involved in development (GO:1902742)2.46940562
139aspartate family amino acid catabolic process (GO:0009068)2.46570397
140low-density lipoprotein particle clearance (GO:0034383)2.45943009
141cell adhesion mediated by integrin (GO:0033627)2.45852525
142positive regulation of p38MAPK cascade (GO:1900745)2.45682578
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.45252969
144myeloid cell activation involved in immune response (GO:0002275)2.45157153
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.44998960
146positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.43921692
147positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.43921692
148positive regulation of mitotic sister chromatid separation (GO:1901970)2.43921692
149leukocyte migration involved in inflammatory response (GO:0002523)2.43255022
150epithelial cell differentiation involved in prostate gland development (GO:0060742)2.42364734
151positive regulation of myotube differentiation (GO:0010831)2.41836220
152activation of Rac GTPase activity (GO:0032863)2.41167414
153negative regulation of chondrocyte differentiation (GO:0032331)2.40910130
154negative regulation of cardiac muscle tissue growth (GO:0055022)2.39961217
155negative regulation of heart growth (GO:0061117)2.39961217
156labyrinthine layer development (GO:0060711)2.39897173
157negative regulation of lymphocyte mediated immunity (GO:0002707)2.39730585
158regulation of SMAD protein import into nucleus (GO:0060390)2.39694705
159pentose-phosphate shunt (GO:0006098)2.39592481
160hemidesmosome assembly (GO:0031581)2.38968319
161positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38445630
162anatomical structure regression (GO:0060033)2.37803202
163regulation of superoxide anion generation (GO:0032928)2.37524679
164negative regulation of cell size (GO:0045792)2.36536886
165positive regulation of mast cell activation (GO:0033005)2.36524527
166negative regulation of leukocyte mediated immunity (GO:0002704)2.36183190
167regulation of podosome assembly (GO:0071801)2.36009950
168regulation of gamma-delta T cell differentiation (GO:0045586)2.35814642
169cell-substrate adherens junction assembly (GO:0007045)2.35388497
170focal adhesion assembly (GO:0048041)2.35388497
171peptide catabolic process (GO:0043171)2.34757136
172regulation of macrophage chemotaxis (GO:0010758)2.33961991
173mitochondrial fusion (GO:0008053)2.33897626
174fatty acid beta-oxidation (GO:0006635)2.33654462
175microglial cell activation (GO:0001774)2.33442616
176substrate adhesion-dependent cell spreading (GO:0034446)2.32867198
177paraxial mesoderm development (GO:0048339)2.32519201
178endodermal cell differentiation (GO:0035987)2.32338557
179modulation by symbiont of host cellular process (GO:0044068)2.32245209
180response to thyroid hormone (GO:0097066)2.32231134
181positive regulation of lamellipodium assembly (GO:0010592)2.32120317
182leukocyte aggregation (GO:0070486)2.31634819
183cellular response to type I interferon (GO:0071357)2.26259484
184type I interferon signaling pathway (GO:0060337)2.26259484
185negative regulation of protein localization to plasma membrane (GO:1903077)2.25570972
186positive regulation of macrophage cytokine production (GO:0060907)2.25005286
187response to type I interferon (GO:0034340)2.24776024
188positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.24225961
189NIK/NF-kappaB signaling (GO:0038061)2.23734642
190glycosphingolipid catabolic process (GO:0046479)2.23602761
191B cell receptor signaling pathway (GO:0050853)2.22238106
192regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.21273465
1933-UTR-mediated mRNA stabilization (GO:0070935)2.20460555
194negative regulation of necroptotic process (GO:0060546)2.19675537
195regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.19600588
196production of molecular mediator involved in inflammatory response (GO:0002532)2.17483980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.98473132
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61739874
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47314953
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.43157097
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.34665470
6* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31726812
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31016638
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28752628
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.28328475
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.23280679
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.17375871
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10969853
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08651282
14RXR_22158963_ChIP-Seq_LIVER_Mouse2.05390525
15VDR_24763502_ChIP-Seq_THP-1_Human2.03966475
16PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03740560
17VDR_21846776_ChIP-Seq_THP-1_Human2.02829483
18* IRF8_27001747_Chip-Seq_BMDM_Mouse1.94698004
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94048281
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.93401101
21STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90776448
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.90493467
23ZNF263_19887448_ChIP-Seq_K562_Human1.87778894
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.86587133
25SPI1_23127762_ChIP-Seq_K562_Human1.85125593
26CLOCK_20551151_ChIP-Seq_293T_Human1.84458488
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84417815
28RACK7_27058665_Chip-Seq_MCF-7_Human1.84281401
29MYC_22102868_ChIP-Seq_BL_Human1.83746930
30ATF3_27146783_Chip-Seq_COLON_Human1.81484822
31* RUNX1_22412390_ChIP-Seq_EML_Mouse1.78260917
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77301154
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76776353
34LXR_22292898_ChIP-Seq_THP-1_Human1.75542377
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.73811412
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.70656036
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69368437
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.67769472
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65115172
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63665321
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.63417276
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62801290
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.62786685
44SCL_19346495_ChIP-Seq_HPC-7_Human1.62678039
45* LXR_22158963_ChIP-Seq_LIVER_Mouse1.62215568
46* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.62180751
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61896796
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.61167759
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.59795709
50* GATA1_19941827_ChIP-Seq_MEL_Mouse1.59660465
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.59377138
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59268752
53SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58584317
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56731853
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55059534
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54944855
57TRIM28_21343339_ChIP-Seq_HEK293_Human1.51299422
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51235733
59KDM2B_26808549_Chip-Seq_DND41_Human1.49767190
60SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49039383
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48927205
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.48577791
63KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47764293
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46647162
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45689738
66UTX_26944678_Chip-Seq_JUKART_Human1.44536098
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43251817
68GATA1_19941826_ChIP-Seq_K562_Human1.42898439
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42597032
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41605928
71* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41494483
72* SPI1_23547873_ChIP-Seq_NB4_Human1.40394378
73AR_21909140_ChIP-Seq_LNCAP_Human1.39700285
74* TBX20_22328084_ChIP-Seq_HEART_Mouse1.38954112
75* TBX20_22080862_ChIP-Seq_HEART_Mouse1.38954112
76ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37262868
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35235914
78* TCF7_22412390_ChIP-Seq_EML_Mouse1.33777559
79E2F7_22180533_ChIP-Seq_HELA_Human1.33608566
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32948482
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31592296
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.28718238
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28113411
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.26245238
85GATA6_25053715_ChIP-Seq_YYC3_Human1.25973418
86SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25750588
87* GATA2_21666600_ChIP-Seq_HMVEC_Human1.25525842
88FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23989575
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23960242
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.21301765
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.21269556
92IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20963466
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19148933
94TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18767004
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18547993
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17636905
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17621834
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17582082
99* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17252286
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16849000
101* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16718578
102CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16591886
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.15205444
104MAF_26560356_Chip-Seq_TH2_Human1.14681197
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14381276
106* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14332872
107TP53_22127205_ChIP-Seq_IMR90_Human1.12801526
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12029973
109RUNX_20019798_ChIP-Seq_JUKART_Human1.11579984
110* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09443565
111* GATA2_19941826_ChIP-Seq_K562_Human1.07627358
112NCOR1_26117541_ChIP-Seq_K562_Human1.07301884
113* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06927824
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06411270
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06019927
116* RUNX1_27514584_Chip-Seq_MCF-7_Human1.05900947
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05346209
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05323804
119* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05268063
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05220223
121MYB_26560356_Chip-Seq_TH1_Human1.04869431
122SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04743879
123ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03714416
124PU_27001747_Chip-Seq_BMDM_Mouse1.02983339
125ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02966022
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.01618404
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00895332
128FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00242006
129POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00026581
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99965437
131FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98917277
132GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98423420
133* KDM2B_26808549_Chip-Seq_K562_Human0.98033723
134MAF_26560356_Chip-Seq_TH1_Human0.97900550
135SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97765947
136* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97708395
137TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97264070
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96044088
139WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95713328
140NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.95547682
141P68_20966046_ChIP-Seq_HELA_Human0.95466921
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94238497
143E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93287698
144GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93266596
145CREB1_26743006_Chip-Seq_LNCaP_Human0.92755623
146* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92750348
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92132356
148CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91824929
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90724608
150UBF1/2_26484160_Chip-Seq_HMECs_Human0.90303628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.54858266
2MP0003303_peritoneal_inflammation3.22872196
3MP0003436_decreased_susceptibility_to3.08522998
4MP0005451_abnormal_body_composition2.95960991
5MP0003724_increased_susceptibility_to2.88763867
6MP0008260_abnormal_autophagy2.67034184
7MP0000751_myopathy2.65128656
8MP0004233_abnormal_muscle_weight2.61675585
9MP0004084_abnormal_cardiac_muscle2.52815128
10MP0005464_abnormal_platelet_physiology2.37900626
11MP0003566_abnormal_cell_adhesion2.37637710
12MP0009278_abnormal_bone_marrow2.35852588
13MP0010352_gastrointestinal_tract_polyps2.33884169
14MP0003646_muscle_fatigue2.23735545
15MP0002419_abnormal_innate_immunity2.22471311
16MP0005330_cardiomyopathy2.05250701
17MP0001835_abnormal_antigen_presentation2.00603287
18MP0002837_dystrophic_cardiac_calcinosis1.99556273
19MP0000685_abnormal_immune_system1.96180346
20MP0004087_abnormal_muscle_fiber1.92709206
21MP0002269_muscular_atrophy1.91800748
22MP0004947_skin_inflammation1.88357807
23MP0000858_altered_metastatic_potential1.87882922
24MP0005025_abnormal_response_to1.86412776
25MP0008438_abnormal_cutaneous_collagen1.81730203
26MP0010630_abnormal_cardiac_muscle1.80098653
27MP0000749_muscle_degeneration1.79028237
28MP0010234_abnormal_vibrissa_follicle1.78558948
29MP0010030_abnormal_orbit_morphology1.72990742
30MP0005000_abnormal_immune_tolerance1.70262480
31MP0001533_abnormal_skeleton_physiology1.67895951
32MP0001790_abnormal_immune_system1.66883573
33MP0005387_immune_system_phenotype1.66883573
34MP0000750_abnormal_muscle_regeneration1.65072328
35MP0005076_abnormal_cell_differentiation1.64366266
36MP0003828_pulmonary_edema1.63020210
37MP0002998_abnormal_bone_remodeling1.60297920
38MP0005023_abnormal_wound_healing1.60175203
39MP0009785_altered_susceptibility_to1.57698469
40MP0008775_abnormal_heart_ventricle1.56860837
41MP0004185_abnormal_adipocyte_glucose1.56234252
42MP0002452_abnormal_antigen_presenting1.53740597
43MP0003279_aneurysm1.53115982
44MP0006082_CNS_inflammation1.51115184
45MP0003183_abnormal_peptide_metabolism1.49044301
46MP0001800_abnormal_humoral_immune1.48505858
47MP0009840_abnormal_foam_cell1.48038119
48MP0002723_abnormal_immune_serum1.46416191
49MP0010155_abnormal_intestine_physiology1.45402796
50MP0003075_altered_response_to1.44523321
51MP0002877_abnormal_melanocyte_morpholog1.43730345
52MP0002420_abnormal_adaptive_immunity1.43671571
53MP0001819_abnormal_immune_cell1.43131875
54MP0001545_abnormal_hematopoietic_system1.42260998
55MP0005397_hematopoietic_system_phenotyp1.42260998
56MP0004858_abnormal_nervous_system1.42178404
57MP0005360_urolithiasis1.41281429
58MP0002148_abnormal_hypersensitivity_rea1.41264549
59MP0005409_darkened_coat_color1.39934662
60MP0004510_myositis1.37573659
61MP0008057_abnormal_DNA_replication1.37441527
62MP0005058_abnormal_lysosome_morphology1.37250379
63MP0000733_abnormal_muscle_development1.36312511
64MP0004130_abnormal_muscle_cell1.35692889
65MP0004036_abnormal_muscle_relaxation1.30583727
66MP0004215_abnormal_myocardial_fiber1.30565612
67MP0003453_abnormal_keratinocyte_physiol1.29791976
68MP0002405_respiratory_system_inflammati1.28563337
69MP0005671_abnormal_response_to1.28214817
70MP0000604_amyloidosis1.26436432
71MP0003329_amyloid_beta_deposits1.25037594
72MP0003191_abnormal_cellular_cholesterol1.24710511
73MP0005085_abnormal_gallbladder_physiolo1.24397074
74MP0003091_abnormal_cell_migration1.24121066
75MP0003950_abnormal_plasma_membrane1.23427530
76MP0005365_abnormal_bile_salt1.21019506
77MP0005666_abnormal_adipose_tissue1.20867274
78MP0000465_gastrointestinal_hemorrhage1.20591851
79MP0001845_abnormal_inflammatory_respons1.19602673
80MP0001544_abnormal_cardiovascular_syste1.18714494
81MP0005385_cardiovascular_system_phenoty1.18714494
82MP0003656_abnormal_erythrocyte_physiolo1.18393846
83MP0002106_abnormal_muscle_physiology1.16979359
84MP0006138_congestive_heart_failure1.16274027
85MP0002086_abnormal_extraembryonic_tissu1.16247192
86MP0010368_abnormal_lymphatic_system1.15638690
87MP0003045_fibrosis1.14981598
88MP0001851_eye_inflammation1.13481032
89MP0000747_muscle_weakness1.12400878
90MP0002398_abnormal_bone_marrow1.12350399
91MP0005623_abnormal_meninges_morphology1.10770989
92MP0003806_abnormal_nucleotide_metabolis1.10571578
93MP0001915_intracranial_hemorrhage1.10564668
94MP0000759_abnormal_skeletal_muscle1.10455089
95MP0003763_abnormal_thymus_physiology1.08903383
96MP0002972_abnormal_cardiac_muscle1.08538352
97MP0005164_abnormal_response_to1.08152911
98MP0000716_abnormal_immune_system1.07803382
99MP0003567_abnormal_fetal_cardiomyocyte1.06476339
100MP0003448_altered_tumor_morphology1.05776223
101MP0004272_abnormal_basement_membrane1.05626627
102MP0003984_embryonic_growth_retardation1.05448084
103MP0004264_abnormal_extraembryonic_tissu1.04973381
104MP0000343_altered_response_to1.04014145
105MP0005166_decreased_susceptibility_to1.02724818
106MP0010307_abnormal_tumor_latency1.02018254
107MP0002088_abnormal_embryonic_growth/wei1.01893925
108MP0001958_emphysema1.01667938
109MP0009333_abnormal_splenocyte_physiolog1.01655459
110MP0005380_embryogenesis_phenotype1.01032294
111MP0001672_abnormal_embryogenesis/_devel1.01032294
112MP0003866_abnormal_defecation1.00973921
113MP0002132_abnormal_respiratory_system1.00850556
114MP0001697_abnormal_embryo_size1.00527928
115MP0008469_abnormal_protein_level0.99938115
116MP0002332_abnormal_exercise_endurance0.99707426
117MP0004381_abnormal_hair_follicle0.99463455
118MP0002139_abnormal_hepatobiliary_system0.99170106
119MP0004883_abnormal_blood_vessel0.99160391
120MP0008004_abnormal_stomach_pH0.98761114
121MP0005257_abnormal_intraocular_pressure0.97872629
122MP0005310_abnormal_salivary_gland0.97025247
123MP0002166_altered_tumor_susceptibility0.96677109
124MP0000767_abnormal_smooth_muscle0.96534419
125MP0000266_abnormal_heart_morphology0.96294447
126MP0002429_abnormal_blood_cell0.95730232
127MP0004197_abnormal_fetal_growth/weight/0.95360899
128MP0003252_abnormal_bile_duct0.94801139
129MP0003221_abnormal_cardiomyocyte_apopto0.94453687
130MP0002722_abnormal_immune_system0.93702049
131MP0003283_abnormal_digestive_organ0.93059530
132MP0001730_embryonic_growth_arrest0.91855588
133MP0004808_abnormal_hematopoietic_stem0.91654769
134MP0005369_muscle_phenotype0.90703708
135MP0000015_abnormal_ear_pigmentation0.89649958
136MP0001853_heart_inflammation0.89481363
137MP0002084_abnormal_developmental_patter0.88464082
138MP0005620_abnormal_muscle_contractility0.88308867
139MP0003690_abnormal_glial_cell0.88092727
140MP0005275_abnormal_skin_tensile0.88054143
141MP0002060_abnormal_skin_morphology0.87827424
142MP0003137_abnormal_impulse_conducting0.86656732
143MP0005083_abnormal_biliary_tract0.86489101
144MP0005319_abnormal_enzyme/_coenzyme0.86096620
145MP0002925_abnormal_cardiovascular_devel0.85317096
146MP0000689_abnormal_spleen_morphology0.84340326
147MP0002282_abnormal_trachea_morphology0.84039117
148MP0003300_gastrointestinal_ulcer0.83988332
149MP0003172_abnormal_lysosome_physiology0.83429490
150MP0002396_abnormal_hematopoietic_system0.82994371
151MP0004957_abnormal_blastocyst_morpholog0.81614879
152MP0005621_abnormal_cell_physiology0.81257477
153MP0002128_abnormal_blood_circulation0.81124518
154MP0000350_abnormal_cell_proliferation0.80556168
155MP0009115_abnormal_fat_cell0.80205851
156MP0003795_abnormal_bone_structure0.79345242
157MP0005165_increased_susceptibility_to0.79184252
158MP0002085_abnormal_embryonic_tissue0.79159172
159MP0005266_abnormal_metabolism0.79039056
160MP0002168_other_aberrant_phenotype0.78048563
161MP0002653_abnormal_ependyma_morphology0.78014630
162MP0009384_cardiac_valve_regurgitation0.77922362
163MP0005375_adipose_tissue_phenotype0.77829161
164MP0005670_abnormal_white_adipose0.77303475
165MP0000249_abnormal_blood_vessel0.76857101
166MP0001849_ear_inflammation0.75179964
167MP0009764_decreased_sensitivity_to0.74897733
168MP0009763_increased_sensitivity_to0.74065767
169MP0005390_skeleton_phenotype0.73424383

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.48591076
2Cerebral aneurysm (HP:0004944)4.00078287
3Right ventricular cardiomyopathy (HP:0011663)3.96838877
4Increased connective tissue (HP:0009025)3.90339284
5Abnormality of macrophages (HP:0004311)3.79845643
6Recurrent abscess formation (HP:0002722)3.52280739
7Ulnar bowing (HP:0003031)3.47138909
8Ventricular tachycardia (HP:0004756)3.43818117
9Muscle fiber splitting (HP:0003555)3.37188862
10Recurrent bacterial skin infections (HP:0005406)3.33640095
11Alopecia of scalp (HP:0002293)3.26734297
12Asymmetric septal hypertrophy (HP:0001670)3.25055712
13Difficulty climbing stairs (HP:0003551)3.22213304
14Protrusio acetabuli (HP:0003179)3.09292481
15Recurrent gram-negative bacterial infections (HP:0005420)3.09195759
16Sudden death (HP:0001699)3.06418576
17Polycythemia (HP:0001901)2.97108929
18Hyporeflexia of lower limbs (HP:0002600)2.94607887
19Hypoplastic ischia (HP:0003175)2.87954801
20Flat acetabular roof (HP:0003180)2.85581231
21Abnormality of glycolipid metabolism (HP:0010969)2.81615033
22Abnormality of liposaccharide metabolism (HP:0010968)2.81615033
23Abnormality of glycosphingolipid metabolism (HP:0004343)2.81615033
24Myositis (HP:0100614)2.80620073
25Orchitis (HP:0100796)2.78194769
26Cellulitis (HP:0100658)2.64807448
27Spontaneous hematomas (HP:0007420)2.63982619
28Gingivitis (HP:0000230)2.62963131
29Prolonged bleeding time (HP:0003010)2.62777441
30Purpura (HP:0000979)2.62431770
31Pustule (HP:0200039)2.61098782
32Premature rupture of membranes (HP:0001788)2.57826778
33Metaphyseal cupping (HP:0003021)2.57541502
34Lipoatrophy (HP:0100578)2.54537669
35Exercise-induced muscle cramps (HP:0003710)2.51307036
36Abnormal platelet volume (HP:0011876)2.49358399
37Aneurysm (HP:0002617)2.49134381
38Ankle contracture (HP:0006466)2.48707393
39Gingival bleeding (HP:0000225)2.48691109
40Aplasia of the musculature (HP:0100854)2.47978027
41Myoglobinuria (HP:0002913)2.45538910
42Exercise-induced myalgia (HP:0003738)2.45321706
43Bowed forearm bones (HP:0003956)2.45318026
44Bowing of the arm (HP:0006488)2.45318026
45Male infertility (HP:0003251)2.44869233
46Abnormality of the ischium (HP:0003174)2.44340795
47Mediastinal lymphadenopathy (HP:0100721)2.39511534
48Epistaxis (HP:0000421)2.39313525
49Diaphragmatic weakness (HP:0009113)2.39104991
50Loss of speech (HP:0002371)2.39092755
51Amyloidosis (HP:0011034)2.38195987
52Obstructive lung disease (HP:0006536)2.37394630
53Chronic obstructive pulmonary disease (HP:0006510)2.37394630
54Atrial fibrillation (HP:0005110)2.35398888
55Type 1 muscle fiber predominance (HP:0003803)2.34332322
56Generalized amyotrophy (HP:0003700)2.34086922
57Increased cerebral lipofuscin (HP:0011813)2.33923693
58Gastrointestinal infarctions (HP:0005244)2.33152709
59Muscle fibrillation (HP:0010546)2.33072628
60Vertebral compression fractures (HP:0002953)2.29393191
61Interstitial pulmonary disease (HP:0006530)2.28873827
62Aortic aneurysm (HP:0004942)2.26708233
63Optic neuritis (HP:0100653)2.24919652
64Retrobulbar optic neuritis (HP:0100654)2.24919652
65Hemorrhage of the eye (HP:0011885)2.23483185
66Peritonitis (HP:0002586)2.23169589
67Segmental peripheral demyelination/remyelination (HP:0003481)2.22645849
68Myocardial infarction (HP:0001658)2.22515508
69Distal lower limb muscle weakness (HP:0009053)2.22496738
70Mildly elevated creatine phosphokinase (HP:0008180)2.20854975
71Thin ribs (HP:0000883)2.18268510
72Turricephaly (HP:0000262)2.17982716
73Increased mean platelet volume (HP:0011877)2.17206591
74Difficulty running (HP:0009046)2.17197276
75Primary atrial arrhythmia (HP:0001692)2.17058230
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.16822076
77Menorrhagia (HP:0000132)2.16623248
78Mucopolysacchariduria (HP:0008155)2.15100685
79Urinary glycosaminoglycan excretion (HP:0003541)2.15100685
80Vertebral hypoplasia (HP:0008417)2.14720586
81Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.14720586
82Increased IgE level (HP:0003212)2.12792054
83Systemic lupus erythematosus (HP:0002725)2.12724302
84Upper limb amyotrophy (HP:0009129)2.12652419
85Distal upper limb amyotrophy (HP:0007149)2.12652419
86Petechiae (HP:0000967)2.12619670
87Supraventricular arrhythmia (HP:0005115)2.09627652
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09312885
89Urticaria (HP:0001025)2.08053480
90Abnormality of the calf musculature (HP:0001430)2.07813015
91Subacute progressive viral hepatitis (HP:0006572)2.06975897
92Supraventricular tachycardia (HP:0004755)2.06283974
93Cerebral inclusion bodies (HP:0100314)2.06059204
94Short humerus (HP:0005792)2.04231162
95Cervical subluxation (HP:0003308)2.02891443
96Bilateral sensorineural hearing impairment (HP:0008619)2.02738856
97Rib fusion (HP:0000902)2.02446628
98Centrally nucleated skeletal muscle fibers (HP:0003687)2.01426243
99EMG: myopathic abnormalities (HP:0003458)2.01123804
100Deep venous thrombosis (HP:0002625)2.00811410
101Generalized muscle weakness (HP:0003324)1.98047562
102Scapular winging (HP:0003691)1.97288299
103Arterial thrombosis (HP:0004420)1.96933888
104Recurrent skin infections (HP:0001581)1.96500521
105Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95882456
106Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95882456
107Abnormality of polysaccharide metabolism (HP:0011012)1.95882456
108Amniotic constriction ring (HP:0009775)1.93693313
109Abnormality of placental membranes (HP:0011409)1.93693313
110Joint stiffness (HP:0001387)1.93282249
111Neurofibrillary tangles (HP:0002185)1.93043851
112Recurrent fungal infections (HP:0002841)1.92911363
113Popliteal pterygium (HP:0009756)1.92681882
114Dilated cardiomyopathy (HP:0001644)1.92049249
115Palpitations (HP:0001962)1.91011698
116Osteolytic defects of the hand bones (HP:0009699)1.89643236
117Osteolytic defects of the phalanges of the hand (HP:0009771)1.89643236
118Meningitis (HP:0001287)1.89357671
119Rhabdomyolysis (HP:0003201)1.88929094
120Dysostosis multiplex (HP:0000943)1.88726101
121Ventricular arrhythmia (HP:0004308)1.88474855
122Broad face (HP:0000283)1.88285582
123Gastrointestinal inflammation (HP:0004386)1.87968424
124Abnormality of the neuromuscular junction (HP:0003398)1.87488263
125Fatigable weakness (HP:0003473)1.87488263
126Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86707622
127Hip contracture (HP:0003273)1.86504670
128Congenital hip dislocation (HP:0001374)1.85883648
129Spinal rigidity (HP:0003306)1.85575676
130Hyperacusis (HP:0010780)1.85411836
131Colitis (HP:0002583)1.84927902
132Dilatation of the ascending aorta (HP:0005111)1.84590971
133Atrioventricular block (HP:0001678)1.83686382
134Slow saccadic eye movements (HP:0000514)1.83629848
135Limb-girdle muscle atrophy (HP:0003797)1.83452779
136Osteomyelitis (HP:0002754)1.82788629
137Polygenic inheritance (HP:0010982)1.82647937
138Arterial tortuosity (HP:0005116)1.81823544
139Vertebral clefting (HP:0008428)1.80981410
140Aortic dissection (HP:0002647)1.80863717
141Disproportionate tall stature (HP:0001519)1.79166858
142Vasculitis (HP:0002633)1.79128898
143Elevated erythrocyte sedimentation rate (HP:0003565)1.79080436
144Distal lower limb amyotrophy (HP:0008944)1.78688113
145Ketoacidosis (HP:0001993)1.78467213
146Abnormal platelet function (HP:0011869)1.77837587
147Impaired platelet aggregation (HP:0003540)1.77837587
148Aplasia/hypoplasia of the humerus (HP:0006507)1.77626291
149Chest pain (HP:0100749)1.77585252
150Esophageal varix (HP:0002040)1.77548151
151Abnormality of the peritoneum (HP:0002585)1.77427581
152Inflammation of the large intestine (HP:0002037)1.77393166
153Broad metatarsal (HP:0001783)1.77123017
154Pathologic fracture (HP:0002756)1.77011888
155Increased neuronal autofluorescent lipopigment (HP:0002074)1.76926340
156Gowers sign (HP:0003391)1.75424962
157Mesangial abnormality (HP:0001966)1.75274546
158Ovoid vertebral bodies (HP:0003300)1.74040559
159Abnormality of the distal phalanges of the toes (HP:0010182)1.73828911
160Pterygium (HP:0001059)1.73739473
161Upper motor neuron abnormality (HP:0002127)1.73626630
162Bundle branch block (HP:0011710)1.73014710
163Hepatosplenomegaly (HP:0001433)1.71290342
164Abnormal atrioventricular conduction (HP:0005150)1.71226715
165Tongue fasciculations (HP:0001308)1.71168621
166Bone pain (HP:0002653)1.70999514
167Thin bony cortex (HP:0002753)1.70906077
168Blue sclerae (HP:0000592)1.70744416
169Malnutrition (HP:0004395)1.70532431
170Increased variability in muscle fiber diameter (HP:0003557)1.70498607
171Abnormality of proline metabolism (HP:0010907)1.70226145
172Hydroxyprolinuria (HP:0003080)1.70226145
173Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69390408
174Axonal loss (HP:0003447)1.68830937
175Onion bulb formation (HP:0003383)1.68776080
176Gastrointestinal stroma tumor (HP:0100723)1.68353716
177Cupped ribs (HP:0000887)1.67698676
178Keratoconjunctivitis sicca (HP:0001097)1.67637058
179Abnormal hemoglobin (HP:0011902)1.67604856
180Vacuolated lymphocytes (HP:0001922)1.66596547
181Viral hepatitis (HP:0006562)1.65044227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.69787591
2DDR23.50312787
3RIPK43.25725330
4ICK3.23096618
5TTN3.16407877
6PRPF4B2.76763647
7PKN22.64161227
8MAP3K62.45457573
9LATS12.44328517
10SMG12.30814058
11PDGFRA2.19060122
12MAP3K112.16260401
13LATS22.03089806
14BLK1.90149077
15FGFR41.89654773
16IRAK31.82318590
17BMX1.77104905
18TYK21.76762158
19PINK11.76740536
20NEK11.76714267
21MAP3K131.76616627
22TRPM71.76041408
23IRAK41.74247468
24MAP4K11.73324317
25ERN11.69692605
26EPHA21.69455847
27MAP3K141.66451095
28STK101.65061914
29MAPK151.61517142
30RIPK11.56404838
31ZAP701.56039237
32DMPK1.51838943
33MAPKAPK31.51711805
34MATK1.51282364
35MAP3K101.49821692
36STK38L1.46481635
37KSR21.46151140
38EEF2K1.42132838
39CDK121.39807134
40PAK41.36861365
41MAP3K11.30119738
42PIM21.28826398
43TYRO31.25993366
44CDK61.25175378
45TBK11.24161246
46JAK31.22767041
47MARK21.18124390
48STK31.17753169
49TGFBR21.16573328
50CSK1.14822121
51LRRK21.14657622
52PDK31.14393054
53PDK41.14393054
54LMTK21.13441108
55MAP3K31.12878898
56SIK11.12133806
57MOS1.11691339
58PRKD21.10692362
59MTOR1.08508808
60GRK61.07741869
61PDPK11.07301530
62FES1.06983700
63DYRK1B1.02502185
64TAOK11.02496988
65MAP3K21.00960554
66FGR0.98911029
67MAP2K30.98154572
68JAK10.96980085
69HCK0.96404303
70PTK60.96361858
71BCKDK0.95144365
72RPS6KB20.93457395
73PTK20.92087965
74FGFR30.91837358
75MST1R0.90670271
76PDK20.90590937
77TESK20.89619988
78FLT30.88058025
79NEK20.87858165
80IRAK20.87226482
81BTK0.86614846
82CDK70.86389770
83PHKG20.84909660
84PHKG10.84909660
85JAK20.83184252
86PIM10.81935447
87SGK30.81043526
88MAPK110.80625852
89YES10.80083436
90PDK10.78878437
91TTK0.78540688
92TNK20.76965498
93CSF1R0.75795938
94CDC42BPA0.75170493
95PAK20.74511822
96MAP3K80.74314167
97CAMK1D0.74090860
98MYLK0.73670233
99RPS6KA20.73531548
100PRKAA10.73056160
101PRKAA20.72921874
102PDGFRB0.71373341
103NEK90.70863180
104RPS6KL10.68599720
105RPS6KC10.68599720
106EPHB10.67904886
107RET0.67840348
108IKBKE0.66276283
109SIK30.65118439
110ARAF0.63470321
111SYK0.63371627
112NME20.62516849
113RPS6KA60.62361894
114RPS6KA40.62182626
115MAP3K70.59289194
116GSK3A0.58449059
117CDK40.58195603
118PRKD10.56090842
119LYN0.55589451
120SCYL20.55313749
121STK380.52497314
122DAPK10.51547828
123ILK0.51198768
124CAMK1G0.50411109
125TESK10.49827989
126IRAK10.49746831
127PRKG20.49514714
128TIE10.49016270
129MAPK120.47387067
130LCK0.46649516
131TAOK30.44501770
132FYN0.43648270
133RPS6KA10.43259367
134TAOK20.42984900
135AURKB0.42877057
136MAP3K50.42629381
137HIPK20.42561244
138KSR10.40646612
139CDC70.40359874
140WNK10.39300585
141PLK10.38022079
142MAP2K10.36021858
143AKT20.35927946
144EGFR0.35499710
145MAPKAPK20.34818537
146FER0.33818979
147CHEK20.33597483
148MET0.33204157
149STK40.33186131
150OBSCN0.33006791
151CDK80.32991742
152STK240.30591175

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.84535400
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28039313
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.05839049
4Fatty acid biosynthesis_Homo sapiens_hsa000612.59030461
5Other glycan degradation_Homo sapiens_hsa005112.35913035
6Osteoclast differentiation_Homo sapiens_hsa043802.19305300
7Biosynthesis of amino acids_Homo sapiens_hsa012302.06400531
8Leishmaniasis_Homo sapiens_hsa051402.03218273
9Fatty acid metabolism_Homo sapiens_hsa012121.97128906
10Adherens junction_Homo sapiens_hsa045201.96342307
11Arginine biosynthesis_Homo sapiens_hsa002201.96176930
12B cell receptor signaling pathway_Homo sapiens_hsa046621.88487910
13Fatty acid degradation_Homo sapiens_hsa000711.86573275
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84387500
15Staphylococcus aureus infection_Homo sapiens_hsa051501.82793253
16Carbon metabolism_Homo sapiens_hsa012001.76012270
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.68383062
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63722962
19Lysine degradation_Homo sapiens_hsa003101.59982733
20Propanoate metabolism_Homo sapiens_hsa006401.59342139
21Dilated cardiomyopathy_Homo sapiens_hsa054141.55701820
22Bladder cancer_Homo sapiens_hsa052191.54556679
23Focal adhesion_Homo sapiens_hsa045101.54483506
24Tuberculosis_Homo sapiens_hsa051521.53217247
25Non-small cell lung cancer_Homo sapiens_hsa052231.51243723
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48244707
27Arginine and proline metabolism_Homo sapiens_hsa003301.46958013
28Small cell lung cancer_Homo sapiens_hsa052221.44764428
29mTOR signaling pathway_Homo sapiens_hsa041501.43351883
30Viral myocarditis_Homo sapiens_hsa054161.38121371
31Malaria_Homo sapiens_hsa051441.37675935
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.37025629
33ECM-receptor interaction_Homo sapiens_hsa045121.37008743
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36237627
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33072743
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31600793
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.31366627
38Influenza A_Homo sapiens_hsa051641.28671839
39Pyruvate metabolism_Homo sapiens_hsa006201.27861459
40Base excision repair_Homo sapiens_hsa034101.24922129
41Hepatitis C_Homo sapiens_hsa051601.24432352
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21642788
43Renal cell carcinoma_Homo sapiens_hsa052111.21011504
44Hippo signaling pathway_Homo sapiens_hsa043901.20957191
45TNF signaling pathway_Homo sapiens_hsa046681.20630696
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16842559
47Endometrial cancer_Homo sapiens_hsa052131.16658976
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16576943
49Chemokine signaling pathway_Homo sapiens_hsa040621.16512873
50Phagosome_Homo sapiens_hsa041451.15748252
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.12848463
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.11081611
53Measles_Homo sapiens_hsa051621.10581764
54Proteoglycans in cancer_Homo sapiens_hsa052051.10514926
55Hepatitis B_Homo sapiens_hsa051611.09877349
56Platelet activation_Homo sapiens_hsa046111.09220905
57Starch and sucrose metabolism_Homo sapiens_hsa005001.08017419
58p53 signaling pathway_Homo sapiens_hsa041151.07454222
59Chronic myeloid leukemia_Homo sapiens_hsa052201.07152761
60Notch signaling pathway_Homo sapiens_hsa043301.07097956
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.06909613
62Salmonella infection_Homo sapiens_hsa051321.04763878
63PPAR signaling pathway_Homo sapiens_hsa033201.04735509
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01408358
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01398074
66Endocytosis_Homo sapiens_hsa041441.00358460
67Tight junction_Homo sapiens_hsa045301.00031419
68Nitrogen metabolism_Homo sapiens_hsa009100.98660181
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97829074
70Circadian rhythm_Homo sapiens_hsa047100.95310706
71T cell receptor signaling pathway_Homo sapiens_hsa046600.94590656
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94568536
73Fructose and mannose metabolism_Homo sapiens_hsa000510.94332822
74TGF-beta signaling pathway_Homo sapiens_hsa043500.93429573
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92660367
76MicroRNAs in cancer_Homo sapiens_hsa052060.92523817
77Fat digestion and absorption_Homo sapiens_hsa049750.90020792
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89667664
79Caffeine metabolism_Homo sapiens_hsa002320.89633690
80Prolactin signaling pathway_Homo sapiens_hsa049170.88499158
81Hematopoietic cell lineage_Homo sapiens_hsa046400.87864660
82Mismatch repair_Homo sapiens_hsa034300.86952243
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86561602
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.86409178
85Pertussis_Homo sapiens_hsa051330.85616675
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85555635
87Prion diseases_Homo sapiens_hsa050200.85133985
88Shigellosis_Homo sapiens_hsa051310.84951687
89Tryptophan metabolism_Homo sapiens_hsa003800.84762127
90Herpes simplex infection_Homo sapiens_hsa051680.84334612
91Allograft rejection_Homo sapiens_hsa053300.84123181
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.83690891
93Pancreatic cancer_Homo sapiens_hsa052120.83661040
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.83470457
95AMPK signaling pathway_Homo sapiens_hsa041520.83452681
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.82591702
97Galactose metabolism_Homo sapiens_hsa000520.81249623
98Insulin resistance_Homo sapiens_hsa049310.80861863
99Graft-versus-host disease_Homo sapiens_hsa053320.80156463
100Prostate cancer_Homo sapiens_hsa052150.79921296
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77877583
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77758087
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.77315550
104VEGF signaling pathway_Homo sapiens_hsa043700.77300876
105HIF-1 signaling pathway_Homo sapiens_hsa040660.77179245
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.76317650
107Insulin signaling pathway_Homo sapiens_hsa049100.76168854
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75700525
109GnRH signaling pathway_Homo sapiens_hsa049120.75693273
110Cell cycle_Homo sapiens_hsa041100.75345122
111ErbB signaling pathway_Homo sapiens_hsa040120.75318248
112Autoimmune thyroid disease_Homo sapiens_hsa053200.75205661
113Amoebiasis_Homo sapiens_hsa051460.74750986
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73281687
115DNA replication_Homo sapiens_hsa030300.73218498
116Glioma_Homo sapiens_hsa052140.72427138
117Antigen processing and presentation_Homo sapiens_hsa046120.70788127
118Choline metabolism in cancer_Homo sapiens_hsa052310.70751577
119Selenocompound metabolism_Homo sapiens_hsa004500.70409418
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.69769165
121Protein digestion and absorption_Homo sapiens_hsa049740.69562714
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68784413
123Inositol phosphate metabolism_Homo sapiens_hsa005620.67586109
124Folate biosynthesis_Homo sapiens_hsa007900.65415602
125Sulfur relay system_Homo sapiens_hsa041220.65311790
126One carbon pool by folate_Homo sapiens_hsa006700.63642709
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62972845
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62910809
129FoxO signaling pathway_Homo sapiens_hsa040680.62256323
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62169130
131African trypanosomiasis_Homo sapiens_hsa051430.62055923
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.61513338
133Colorectal cancer_Homo sapiens_hsa052100.61203360
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60809563
135Bile secretion_Homo sapiens_hsa049760.59926164
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56634373
137Glutathione metabolism_Homo sapiens_hsa004800.56232016
138Acute myeloid leukemia_Homo sapiens_hsa052210.55540104
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54376294
140Estrogen signaling pathway_Homo sapiens_hsa049150.53989995
141Lysosome_Homo sapiens_hsa041420.52704084
142Legionellosis_Homo sapiens_hsa051340.52490246
143Apoptosis_Homo sapiens_hsa042100.51929455
144Rap1 signaling pathway_Homo sapiens_hsa040150.50818142
145Thyroid cancer_Homo sapiens_hsa052160.50260464
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49897451
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48334599
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48282845
149HTLV-I infection_Homo sapiens_hsa051660.48156704
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.47251464
151Complement and coagulation cascades_Homo sapiens_hsa046100.46532405
152Mineral absorption_Homo sapiens_hsa049780.46140365
153Dorso-ventral axis formation_Homo sapiens_hsa043200.46085575
154Glycerolipid metabolism_Homo sapiens_hsa005610.44811206
155Hedgehog signaling pathway_Homo sapiens_hsa043400.44521362
156beta-Alanine metabolism_Homo sapiens_hsa004100.44451309
157RNA transport_Homo sapiens_hsa030130.44279377
158Toxoplasmosis_Homo sapiens_hsa051450.42826109
159Viral carcinogenesis_Homo sapiens_hsa052030.42480348
160Pentose phosphate pathway_Homo sapiens_hsa000300.40617394
161Glucagon signaling pathway_Homo sapiens_hsa049220.39584851

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »