PACSIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.15937926
2muscle filament sliding (GO:0030049)6.15937926
3sarcomere organization (GO:0045214)5.87620256
4regulation of skeletal muscle contraction (GO:0014819)5.59897037
5actin-mediated cell contraction (GO:0070252)5.12533841
6plasma membrane repair (GO:0001778)5.08611538
7response to muscle activity (GO:0014850)5.00599923
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.90660683
9myofibril assembly (GO:0030239)4.83487126
10cardiac myofibril assembly (GO:0055003)4.75443039
11carnitine shuttle (GO:0006853)4.64873687
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.61955369
13skeletal muscle fiber development (GO:0048741)4.56181735
14sarcoplasmic reticulum calcium ion transport (GO:0070296)4.40730913
15fatty acid transmembrane transport (GO:1902001)4.40415058
16lysine catabolic process (GO:0006554)4.35518214
17lysine metabolic process (GO:0006553)4.35518214
18negative regulation of potassium ion transmembrane transport (GO:1901380)4.30702139
192-oxoglutarate metabolic process (GO:0006103)4.30138949
20tricarboxylic acid cycle (GO:0006099)4.30137831
21creatine metabolic process (GO:0006600)4.24207442
22aspartate family amino acid catabolic process (GO:0009068)4.23780299
23skeletal muscle contraction (GO:0003009)4.19221419
24cardiac muscle contraction (GO:0060048)4.04272410
25regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.99728377
26striated muscle contraction (GO:0006941)3.96657198
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95290365
28L-phenylalanine catabolic process (GO:0006559)3.95290365
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.95190010
30L-phenylalanine metabolic process (GO:0006558)3.95190010
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.93198570
32myotube cell development (GO:0014904)3.91687475
33actomyosin structure organization (GO:0031032)3.89787432
34actin filament-based movement (GO:0030048)3.88274598
35response to inactivity (GO:0014854)3.84932530
36fatty acid beta-oxidation (GO:0006635)3.81355286
37glyoxylate metabolic process (GO:0046487)3.79084564
38regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.78023032
39gluconeogenesis (GO:0006094)3.77312850
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.75071931
41response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.74655320
42muscle system process (GO:0003012)3.72559745
43focal adhesion assembly (GO:0048041)3.72236574
44cell-substrate adherens junction assembly (GO:0007045)3.72236574
45acetyl-CoA metabolic process (GO:0006084)3.69346970
46ventricular cardiac muscle cell action potential (GO:0086005)3.64006210
47cardiac muscle cell development (GO:0055013)3.62080321
48regulation of sequestering of triglyceride (GO:0010889)3.61437574
49triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.57611916
50carnitine transmembrane transport (GO:1902603)3.57114883
51cellular ketone body metabolic process (GO:0046950)3.54042744
52kynurenine metabolic process (GO:0070189)3.50651421
53positive regulation of fatty acid beta-oxidation (GO:0032000)3.50266355
54regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.50222461
55regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.49981290
56hexose biosynthetic process (GO:0019319)3.49168944
57alpha-linolenic acid metabolic process (GO:0036109)3.47389073
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.45360605
59amino-acid betaine metabolic process (GO:0006577)3.45171435
60adherens junction assembly (GO:0034333)3.43443980
61short-chain fatty acid metabolic process (GO:0046459)3.43330911
62striated muscle adaptation (GO:0014888)3.42820714
63regulation of actin filament-based movement (GO:1903115)3.42116203
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.42036527
65fatty acid catabolic process (GO:0009062)3.40050227
66desmosome organization (GO:0002934)3.39167392
67regulation of fatty acid oxidation (GO:0046320)3.38686428
68fatty acid oxidation (GO:0019395)3.38667841
69cardiac cell development (GO:0055006)3.38437325
70adult heart development (GO:0007512)3.38159655
71regulation of acyl-CoA biosynthetic process (GO:0050812)3.38157584
72amino-acid betaine transport (GO:0015838)3.38129019
73carnitine transport (GO:0015879)3.38129019
74glycogen catabolic process (GO:0005980)3.34645982
75lipid oxidation (GO:0034440)3.33713134
76negative regulation of cell size (GO:0045792)3.33111345
77muscle cell fate commitment (GO:0042693)3.33071388
78ethanol oxidation (GO:0006069)3.32873586
79muscle cell cellular homeostasis (GO:0046716)3.32765962
80regulation of triglyceride catabolic process (GO:0010896)3.32397431
81branched-chain amino acid catabolic process (GO:0009083)3.31102646
82carnitine metabolic process (GO:0009437)3.30579024
83positive regulation of fatty acid oxidation (GO:0046321)3.25325368
84regulation of relaxation of muscle (GO:1901077)3.23582901
85aromatic amino acid family catabolic process (GO:0009074)3.23303457
86muscle fiber development (GO:0048747)3.22533069
87monosaccharide biosynthetic process (GO:0046364)3.21816670
88regulation of the force of heart contraction (GO:0002026)3.21786863
89cardiac muscle hypertrophy (GO:0003300)3.21395572
90cardiac muscle tissue morphogenesis (GO:0055008)3.20678804
91polysaccharide catabolic process (GO:0000272)3.19034611
92monocarboxylic acid catabolic process (GO:0072329)3.15008265
93positive regulation of myotube differentiation (GO:0010831)3.14421178
94glucan catabolic process (GO:0009251)3.14375148
95skeletal muscle adaptation (GO:0043501)3.13690887
96skeletal muscle tissue development (GO:0007519)3.13125877
97regulation of cell communication by electrical coupling (GO:0010649)3.13021569
98dicarboxylic acid biosynthetic process (GO:0043650)3.12506066
99striated muscle hypertrophy (GO:0014897)3.12339784
100cell-substrate junction assembly (GO:0007044)3.12327518
101striated muscle atrophy (GO:0014891)3.07304578
102NADH metabolic process (GO:0006734)3.07200279
103muscle hypertrophy (GO:0014896)3.06463176
104sulfur amino acid catabolic process (GO:0000098)3.05903677
105regulation of coenzyme metabolic process (GO:0051196)3.05381622
106regulation of cofactor metabolic process (GO:0051193)3.05381622
107ketone body metabolic process (GO:1902224)3.04325626
108regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.02636031
109muscle tissue morphogenesis (GO:0060415)3.02358295
110muscle contraction (GO:0006936)3.01969176
111bile acid biosynthetic process (GO:0006699)3.01774801
112branched-chain amino acid metabolic process (GO:0009081)2.99421997
113heart trabecula formation (GO:0060347)2.99065637
114biotin metabolic process (GO:0006768)2.98970584
115regulation of striated muscle contraction (GO:0006942)2.98855891
116glycogen metabolic process (GO:0005977)2.96894989
117alpha-amino acid catabolic process (GO:1901606)2.95102578
118regulation of membrane repolarization (GO:0060306)2.95054193
119negative regulation of fibrinolysis (GO:0051918)2.95015958
120valine metabolic process (GO:0006573)2.94426891
121striated muscle cell development (GO:0055002)2.93662869
122glucan biosynthetic process (GO:0009250)2.93553538
123glycogen biosynthetic process (GO:0005978)2.93553538
124response to mercury ion (GO:0046689)2.93177774
125oxaloacetate metabolic process (GO:0006107)2.92079433
126serine family amino acid catabolic process (GO:0009071)2.88489751
127cellular polysaccharide catabolic process (GO:0044247)2.88369493
128fructose metabolic process (GO:0006000)2.88140828
129cellular glucan metabolic process (GO:0006073)2.87806395
130glucan metabolic process (GO:0044042)2.87806395
131glycolytic process (GO:0006096)2.87665346
132ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.86164050
133myoblast fusion (GO:0007520)2.85852007
134muscle organ development (GO:0007517)2.80686545
135muscle atrophy (GO:0014889)2.79824707
136muscle structure development (GO:0061061)2.78726608
137proline biosynthetic process (GO:0006561)2.76356128
138epithelial cell-cell adhesion (GO:0090136)2.72892223
139cardiac muscle adaptation (GO:0014887)2.72354335
140cardiac muscle hypertrophy in response to stress (GO:0014898)2.72354335
141muscle hypertrophy in response to stress (GO:0003299)2.72354335
142positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.72164848
143hemidesmosome assembly (GO:0031581)2.70551677
144muscle adaptation (GO:0043500)2.70428692
1454-hydroxyproline metabolic process (GO:0019471)2.70180502
146positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.69369887
147negative regulation of protein localization to cell surface (GO:2000009)2.68516545
148muscle cell development (GO:0055001)2.61857232
149syncytium formation by plasma membrane fusion (GO:0000768)2.58838290
150planar cell polarity pathway involved in neural tube closure (GO:0090179)2.57787083
151IMP metabolic process (GO:0046040)2.57524469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.03396512
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.88918270
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.76783101
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.33137631
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.95413006
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.41402213
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15956942
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.11909316
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66604689
10ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.60630877
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.51787454
12ZNF263_19887448_ChIP-Seq_K562_Human2.30117592
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.29446317
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.28439034
15* TBX20_22328084_ChIP-Seq_HEART_Mouse2.26355663
16* TBX20_22080862_ChIP-Seq_HEART_Mouse2.26355663
17CLOCK_20551151_ChIP-Seq_293T_Human2.14514991
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09570002
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08189400
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.07296379
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02658721
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96952898
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89394108
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.79716198
25CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74560865
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68784136
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65355452
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.63280419
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50416145
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.49784658
31* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48800919
32TET1_21451524_ChIP-Seq_MESCs_Mouse1.47135360
33* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46160764
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.43604843
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42284090
36* FOXA2_19822575_ChIP-Seq_HepG2_Human1.41550240
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40496752
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38992585
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.38759056
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38101996
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38092917
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37723989
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.37418847
44* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36970756
45MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35540175
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.35341951
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35155406
48* SMC4_20622854_ChIP-Seq_HELA_Human1.33124140
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32990064
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.32253999
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.32182946
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30831419
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28517561
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27713405
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27276529
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26799106
57* KDM2B_26808549_Chip-Seq_DND41_Human1.26366709
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25618377
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25305214
60TCF7_22412390_ChIP-Seq_EML_Mouse1.23675214
61* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23428309
62LXR_22292898_ChIP-Seq_THP-1_Human1.21544745
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.21160980
64STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.20891954
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19761058
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17053512
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16952375
68CTCF_27219007_Chip-Seq_Bcells_Human1.16638295
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15494775
70AR_21909140_ChIP-Seq_LNCAP_Human1.15369442
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.14662193
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14248786
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.13916177
74MYC_22102868_ChIP-Seq_BL_Human1.13382845
75RACK7_27058665_Chip-Seq_MCF-7_Human1.12431940
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10675301
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.09804246
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08680379
79* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08384349
80MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07536141
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07375477
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07049557
83DROSHA_22980978_ChIP-Seq_HELA_Human1.06453482
84PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05586276
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04965716
86VDR_21846776_ChIP-Seq_THP-1_Human1.04690841
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02672694
88MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02652405
89SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02173117
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01736093
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99101238
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99085231
93PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98269008
94E2F7_22180533_ChIP-Seq_HELA_Human0.97747850
95RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94170640
96GATA4_21415370_ChIP-Seq_HL-1_Mouse0.93528376
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93414902
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92780938
99TP63_22573176_ChIP-Seq_HFKS_Human0.92068324
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90082352
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90082352
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88609486
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86377603
104SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86006664
105SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85016092
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.84417978
107* ATF3_27146783_Chip-Seq_COLON_Human0.84009194
108* HNF4A_19822575_ChIP-Seq_HepG2_Human0.82719698
109HTT_18923047_ChIP-ChIP_STHdh_Human0.82470540
110AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81769363
111SMC3_22415368_ChIP-Seq_MEFs_Mouse0.81577803
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81556322
113CREB1_26743006_Chip-Seq_LNCaP_Human0.81346168
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80606826
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80371731
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80371718
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80032093
118SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79933145
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79675276
120* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79206175
121* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79120270
122FOXH1_21741376_ChIP-Seq_ESCs_Human0.78849137
123* P68_20966046_ChIP-Seq_HELA_Human0.78815946
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78543580
125KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78065350
126OCT4_20526341_ChIP-Seq_ESCs_Human0.77747925
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.77180508
128* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.75783563
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.75516097
130* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74955245
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.74439630
132CJUN_26792858_Chip-Seq_BT549_Human0.74042967
133SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73572070
134* EZH2_27294783_Chip-Seq_ESCs_Mouse0.71894001
135NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.71492055
136CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71416377
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.71332641
138RNF2_18974828_ChIP-Seq_MESCs_Mouse0.71332641
139* KDM2B_26808549_Chip-Seq_K562_Human0.70193464
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69162247
141SMC1_22415368_ChIP-Seq_MEFs_Mouse0.68871822
142TP53_20018659_ChIP-ChIP_R1E_Mouse0.67909147
143P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.67551112
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.67290832
145GATA1_19941826_ChIP-Seq_K562_Human0.67140518
146STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66587507

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.16604214
2MP0000751_myopathy4.57344032
3MP0003646_muscle_fatigue4.50701223
4MP0000749_muscle_degeneration3.99072404
5MP0004084_abnormal_cardiac_muscle3.45239668
6MP0002139_abnormal_hepatobiliary_system3.37241378
7MP0004036_abnormal_muscle_relaxation3.33982703
8MP0004145_abnormal_muscle_electrophysio3.23857164
9MP0004215_abnormal_myocardial_fiber2.93549480
10MP0005330_cardiomyopathy2.92788706
11MP0005360_urolithiasis2.83974228
12MP0003806_abnormal_nucleotide_metabolis2.79495364
13MP0004087_abnormal_muscle_fiber2.78457657
14MP0005085_abnormal_gallbladder_physiolo2.76268097
15MP0004130_abnormal_muscle_cell2.66576709
16MP0000747_muscle_weakness2.60372241
17MP0000750_abnormal_muscle_regeneration2.51300410
18MP0005365_abnormal_bile_salt2.47837152
19MP0002269_muscular_atrophy2.47551552
20MP0002106_abnormal_muscle_physiology2.43145750
21MP0005620_abnormal_muscle_contractility2.33516511
22MP0000759_abnormal_skeletal_muscle2.17289360
23MP0002972_abnormal_cardiac_muscle2.10384549
24MP0005369_muscle_phenotype2.05411730
25MP0010030_abnormal_orbit_morphology2.00438815
26MP0009840_abnormal_foam_cell1.96790388
27MP0005083_abnormal_biliary_tract1.94364958
28MP0003137_abnormal_impulse_conducting1.88748586
29MP0008875_abnormal_xenobiotic_pharmacok1.85215310
30MP0010630_abnormal_cardiac_muscle1.82710620
31MP0001544_abnormal_cardiovascular_syste1.71468428
32MP0005385_cardiovascular_system_phenoty1.71468428
33MP0003705_abnormal_hypodermis_morpholog1.71201862
34MP0008775_abnormal_heart_ventricle1.71027709
35MP0010234_abnormal_vibrissa_follicle1.70095303
36MP0003252_abnormal_bile_duct1.67963300
37MP0006036_abnormal_mitochondrial_physio1.63696302
38MP0005666_abnormal_adipose_tissue1.59879984
39MP0001661_extended_life_span1.59574789
40MP0010329_abnormal_lipoprotein_level1.58456111
41MP0006138_congestive_heart_failure1.55163179
42MP0004233_abnormal_muscle_weight1.52874039
43MP0003195_calcinosis1.51819539
44MP0004484_altered_response_of1.48098811
45MP0003950_abnormal_plasma_membrane1.43739404
46MP0003941_abnormal_skin_development1.43687895
47MP0005332_abnormal_amino_acid1.42106816
48MP0005670_abnormal_white_adipose1.38346534
49MP0004185_abnormal_adipocyte_glucose1.35678159
50MP0002332_abnormal_exercise_endurance1.28617482
51MP0003221_abnormal_cardiomyocyte_apopto1.27831619
52MP0002108_abnormal_muscle_morphology1.26262394
53MP0002118_abnormal_lipid_homeostasis1.22055763
54MP0004085_abnormal_heartbeat1.20961244
55MP0005451_abnormal_body_composition1.16503548
56MP0005375_adipose_tissue_phenotype1.11523269
57MP0002971_abnormal_brown_adipose1.10448467
58MP0005319_abnormal_enzyme/_coenzyme1.09825960
59MP0000733_abnormal_muscle_development1.09609517
60MP0008438_abnormal_cutaneous_collagen1.07395520
61MP0004858_abnormal_nervous_system1.04373682
62MP0002234_abnormal_pharynx_morphology1.03280510
63MP0001666_abnormal_nutrient_absorption1.03054944
64MP0002127_abnormal_cardiovascular_syste0.99906125
65MP0001849_ear_inflammation0.99224369
66MP0009672_abnormal_birth_weight0.97039286
67MP0005275_abnormal_skin_tensile0.96906469
68MP0002877_abnormal_melanocyte_morpholog0.94350605
69MP0005584_abnormal_enzyme/coenzyme_acti0.92716069
70MP0006035_abnormal_mitochondrial_morpho0.92346045
71MP0005266_abnormal_metabolism0.91741218
72MP0005076_abnormal_cell_differentiation0.89370456
73MP0003279_aneurysm0.89099427
74MP0000609_abnormal_liver_physiology0.87172639
75MP0001346_abnormal_lacrimal_gland0.85822285
76MP0000467_abnormal_esophagus_morphology0.85658478
77MP0010368_abnormal_lymphatic_system0.85593391
78MP0001299_abnormal_eye_distance/0.85403486
79MP0002060_abnormal_skin_morphology0.83339636
80MP0003191_abnormal_cellular_cholesterol0.82979834
81MP0003828_pulmonary_edema0.82156511
82MP0009384_cardiac_valve_regurgitation0.81714771
83MP0005501_abnormal_skin_physiology0.80350634
84MP0005257_abnormal_intraocular_pressure0.79583027
85MP0004043_abnormal_pH_regulation0.76330996
86MP0000537_abnormal_urethra_morphology0.75126599
87MP0003453_abnormal_keratinocyte_physiol0.73962470
88MP0003123_paternal_imprinting0.73945268
89MP0004270_analgesia0.73879648
90MP0003329_amyloid_beta_deposits0.73562925
91MP0000566_synostosis0.73496117
92MP0000013_abnormal_adipose_tissue0.73282143
93MP0002249_abnormal_larynx_morphology0.72959106
94MP0000266_abnormal_heart_morphology0.70744963
95MP0000003_abnormal_adipose_tissue0.67469670
96MP0005165_increased_susceptibility_to0.66770008
97MP0000343_altered_response_to0.66502423
98MP0004510_myositis0.65618254
99MP0002896_abnormal_bone_mineralization0.65459881
100MP0002078_abnormal_glucose_homeostasis0.65252800
101MP0005409_darkened_coat_color0.64323516
102MP0000230_abnormal_systemic_arterial0.64276783
103MP0003656_abnormal_erythrocyte_physiolo0.63975344
104MP0008260_abnormal_autophagy0.63655222
105MP0000579_abnormal_nail_morphology0.62795637
106MP0002128_abnormal_blood_circulation0.59114429
107MP0001730_embryonic_growth_arrest0.57261670
108MP0002796_impaired_skin_barrier0.56753946
109MP0005623_abnormal_meninges_morphology0.56702777
110MP0009250_abnormal_appendicular_skeleto0.53576494
111MP0009780_abnormal_chondrocyte_physiolo0.53300290
112MP0003566_abnormal_cell_adhesion0.52823441
113MP0005334_abnormal_fat_pad0.52550467
114MP0009643_abnormal_urine_homeostasis0.52416102
115MP0005058_abnormal_lysosome_morphology0.52402545
116MP0000678_abnormal_parathyroid_gland0.52156346
117MP0003385_abnormal_body_wall0.51512360
118MP0003984_embryonic_growth_retardation0.51456765
119MP0002114_abnormal_axial_skeleton0.50153669
120MP0002089_abnormal_postnatal_growth/wei0.49650558
121MP0002088_abnormal_embryonic_growth/wei0.48239822
122MP0000534_abnormal_ureter_morphology0.48008096
123MP0000767_abnormal_smooth_muscle0.47621560
124MP0004197_abnormal_fetal_growth/weight/0.46104004
125MP0003567_abnormal_fetal_cardiomyocyte0.45531299
126MP0004272_abnormal_basement_membrane0.45510566
127MP0003942_abnormal_urinary_system0.45328648
128MP0005187_abnormal_penis_morphology0.44540812
129MP0005376_homeostasis/metabolism_phenot0.43540919
130MP0008961_abnormal_basal_metabolism0.43220252
131MP0003690_abnormal_glial_cell0.43177365
132MP0005535_abnormal_body_temperature0.43151945
133MP0000762_abnormal_tongue_morphology0.41847839
134MP0004019_abnormal_vitamin_homeostasis0.39339433
135MP0003011_delayed_dark_adaptation0.38543872
136MP0000604_amyloidosis0.38380313
137MP0002138_abnormal_hepatobiliary_system0.36634086

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.27562031
2Exercise-induced muscle cramps (HP:0003710)5.77659352
3Calf muscle hypertrophy (HP:0008981)5.48221971
4Muscle hypertrophy of the lower extremities (HP:0008968)5.44712157
5Muscle fiber splitting (HP:0003555)5.30945634
6Sudden death (HP:0001699)5.24353555
7Muscle fiber inclusion bodies (HP:0100299)5.23256528
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.07927192
9Hyporeflexia of lower limbs (HP:0002600)5.04121935
10Myoglobinuria (HP:0002913)4.73421218
11Type 1 muscle fiber predominance (HP:0003803)4.62622385
12Nemaline bodies (HP:0003798)4.51996572
13Abnormality of the calf musculature (HP:0001430)4.40227598
14Centrally nucleated skeletal muscle fibers (HP:0003687)4.39777436
15Ventricular tachycardia (HP:0004756)4.28212334
16EMG: myopathic abnormalities (HP:0003458)4.12223512
17Increased connective tissue (HP:0009025)4.09954013
18Difficulty running (HP:0009046)4.09321994
19Right ventricular cardiomyopathy (HP:0011663)3.94202954
20Rhabdomyolysis (HP:0003201)3.59647992
21Abnormality of the left ventricular outflow tract (HP:0011103)3.45239895
22Subaortic stenosis (HP:0001682)3.45239895
23Distal arthrogryposis (HP:0005684)3.41877804
24Myotonia (HP:0002486)3.32187295
25Round ear (HP:0100830)3.32117641
26Lipoatrophy (HP:0100578)3.31291603
27Asymmetric septal hypertrophy (HP:0001670)3.24514846
28Muscle stiffness (HP:0003552)3.21949644
29Atrial fibrillation (HP:0005110)3.21720782
30Myopathic facies (HP:0002058)3.02039678
31Difficulty climbing stairs (HP:0003551)2.99653937
32Dilated cardiomyopathy (HP:0001644)2.99631311
33Ketosis (HP:0001946)2.97572585
34Bundle branch block (HP:0011710)2.95534787
35Primary atrial arrhythmia (HP:0001692)2.94884169
36Hypoalphalipoproteinemia (HP:0003233)2.92822084
37Ketoacidosis (HP:0001993)2.92003358
38Increased variability in muscle fiber diameter (HP:0003557)2.91965219
39Abnormality of skeletal muscle fiber size (HP:0012084)2.90211901
40Xanthomatosis (HP:0000991)2.87386752
41Palpitations (HP:0001962)2.84254969
42Deep venous thrombosis (HP:0002625)2.84250338
43Supraventricular tachycardia (HP:0004755)2.82301737
44Progressive muscle weakness (HP:0003323)2.81609017
45Supraventricular arrhythmia (HP:0005115)2.77550105
46Heart block (HP:0012722)2.76618755
47Hyperammonemia (HP:0001987)2.76326128
48Hypoglycemic coma (HP:0001325)2.76042509
49Syncope (HP:0001279)2.74825515
50Abnormality of fatty-acid metabolism (HP:0004359)2.74494953
51Atrioventricular block (HP:0001678)2.72355635
52Intrahepatic cholestasis (HP:0001406)2.68100111
53Abnormal atrioventricular conduction (HP:0005150)2.67508928
54Abnormality of the calcaneus (HP:0008364)2.66336625
55Hyperlipoproteinemia (HP:0010980)2.65387031
56Bulbar palsy (HP:0001283)2.63570515
57Ventricular arrhythmia (HP:0004308)2.61599755
58Distal lower limb muscle weakness (HP:0009053)2.59580929
59Neck muscle weakness (HP:0000467)2.58859311
60Hyperglycinuria (HP:0003108)2.48361912
61Abnormality of aromatic amino acid family metabolism (HP:0004338)2.43541902
62Ulnar deviation of the wrist (HP:0003049)2.42568303
63Abnormality of glycine metabolism (HP:0010895)2.42105632
64Abnormality of serine family amino acid metabolism (HP:0010894)2.42105632
65Lower limb amyotrophy (HP:0007210)2.41066310
66Cholelithiasis (HP:0001081)2.40727936
67Ragged-red muscle fibers (HP:0003200)2.38371185
68Hypolipoproteinemia (HP:0010981)2.37378682
69Prolonged QT interval (HP:0001657)2.35005718
70Areflexia of lower limbs (HP:0002522)2.34987858
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33492860
72Dicarboxylic aciduria (HP:0003215)2.33492860
73Abnormal gallbladder morphology (HP:0012437)2.24044272
74Limb-girdle muscle atrophy (HP:0003797)2.23150034
75Mildly elevated creatine phosphokinase (HP:0008180)2.23063590
76Absent phalangeal crease (HP:0006109)2.23038483
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21927348
78Cerebral edema (HP:0002181)2.20125854
79EMG: neuropathic changes (HP:0003445)2.16494123
80Calcaneovalgus deformity (HP:0001848)2.14592595
81Hyperglycinemia (HP:0002154)2.14071627
82Abnormality of the foot musculature (HP:0001436)2.13768999
83Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.12898305
84Popliteal pterygium (HP:0009756)2.09631969
85Rimmed vacuoles (HP:0003805)2.09395219
86Foot dorsiflexor weakness (HP:0009027)2.08850663
87Abnormality of monocarboxylic acid metabolism (HP:0010996)2.06336480
88Gowers sign (HP:0003391)2.03807789
89Slender build (HP:0001533)2.02650840
90Abnormality of the Achilles tendon (HP:0005109)2.01904332
91Gout (HP:0001997)2.01004571
92Fatigable weakness (HP:0003473)2.00033680
93Abnormality of the neuromuscular junction (HP:0003398)2.00033680
94Distal lower limb amyotrophy (HP:0008944)1.97668863
95Fetal akinesia sequence (HP:0001989)1.96386079
96Deformed tarsal bones (HP:0008119)1.94103107
97Scapular winging (HP:0003691)1.93903911
98Hypoplastic ischia (HP:0003175)1.92249029
99Generalized muscle weakness (HP:0003324)1.91659200
100Ventricular fibrillation (HP:0001663)1.91640579
101Hepatic necrosis (HP:0002605)1.91591306
102Metatarsus adductus (HP:0001840)1.91085571
103Hypobetalipoproteinemia (HP:0003563)1.90315847
104Metabolic acidosis (HP:0001942)1.89904683
105Malignant hyperthermia (HP:0002047)1.89904287
106Trismus (HP:0000211)1.89683145
107Muscular dystrophy (HP:0003560)1.87984422
108Hip contracture (HP:0003273)1.87879739
109Frequent falls (HP:0002359)1.84838028
110Achilles tendon contracture (HP:0001771)1.84554814
111Weak cry (HP:0001612)1.83390260
112Abnormality of the shoulder girdle musculature (HP:0001435)1.79706957
113Generalized amyotrophy (HP:0003700)1.79377345
114Palmoplantar keratoderma (HP:0000982)1.79204292
115Abnormal finger flexion creases (HP:0006143)1.78947849
116Testicular atrophy (HP:0000029)1.78444057
117Acute encephalopathy (HP:0006846)1.78155651
118Spinal rigidity (HP:0003306)1.78146531
119Abnormality of the ischium (HP:0003174)1.77377948
120Waddling gait (HP:0002515)1.77212680
121Protrusio acetabuli (HP:0003179)1.77170791
122Pterygium (HP:0001059)1.76564449
123Breech presentation (HP:0001623)1.73629914
124Premature rupture of membranes (HP:0001788)1.72137446
125Proximal amyotrophy (HP:0007126)1.71477963
126Limb-girdle muscle weakness (HP:0003325)1.67190450
127Shoulder girdle muscle weakness (HP:0003547)1.64626094
128Back pain (HP:0003418)1.61462770
129Stridor (HP:0010307)1.60909057
130Hyperkalemia (HP:0002153)1.58256265
131Respiratory insufficiency due to muscle weakness (HP:0002747)1.58106484
132Pelvic girdle muscle weakness (HP:0003749)1.57149167
133Adducted thumb (HP:0001181)1.53305336
134Congenital hip dislocation (HP:0001374)1.47094784
135Dysmetric saccades (HP:0000641)1.45922808
136Abnormality of the musculature of the pelvis (HP:0001469)1.44864018
137Abnormality of the hip-girdle musculature (HP:0001445)1.44864018
138Thin ribs (HP:0000883)1.44269576
139Limited hip movement (HP:0008800)1.43166626
140Exercise intolerance (HP:0003546)1.39127012

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.60697514
2OBSCN5.36069990
3PHKG24.16659433
4PHKG14.16659433
5BCKDK3.68781462
6TRIB33.41693779
7EEF2K2.61601445
8LMTK22.48492571
9PDK32.46637232
10PDK42.46637232
11EPHA22.39466137
12PKN22.23416720
13PINK12.20687933
14PIK3CA2.18042063
15DMPK2.06592374
16PIK3CG1.99982772
17SIK11.91813939
18MUSK1.84783773
19MYLK1.83796766
20NEK11.81004060
21SMG11.69610382
22PDK21.63846800
23MAP3K71.57971800
24NME21.43363336
25MAPK121.41718149
26RPS6KB21.36587649
27MAP2K31.34060663
28EPHB11.33424458
29LIMK11.33110019
30RIPK11.31736443
31TESK11.19588247
32NME11.19575238
33PAK31.16779791
34ERN11.11760311
35IRAK31.09632954
36PRKD11.04576859
37TIE11.04429794
38MAP2K41.01806124
39FGFR41.00645068
40CAMK2D0.97551111
41PKN10.95127072
42PBK0.93846677
43MAP3K30.93213687
44LATS10.92943608
45ARAF0.89698415
46PRKAA20.89604766
47INSRR0.88709601
48CAMK2G0.86979105
49PAK40.86917378
50STK38L0.86719697
51ILK0.85585443
52PTK60.84531681
53PRKAA10.83574856
54MAPKAPK30.83100239
55SCYL20.82838928
56PDGFRA0.80215435
57ROCK10.77769903
58CDK120.75193645
59LATS20.72622432
60STK240.70754784
61WNK40.69109719
62MOS0.67018591
63STK390.64912045
64ICK0.63236645
65PRPF4B0.62871275
66STK380.62200806
67DAPK30.61767969
68CCNB10.61027021
69MAP3K100.59703258
70MAPK110.58952352
71ROCK20.58902299
72NEK90.58413268
73TAOK10.57577109
74TAOK20.56892747
75FGFR20.54965198
76FER0.53994206
77TRPM70.53467132
78MAP3K50.52709963
79PDPK10.51956094
80CAMK2B0.51630638
81AKT20.50444475
82MAP3K60.50210227
83CAMK40.48472421
84MET0.48126073
85PRKACB0.47766852
86MAP2K60.46814436
87CDC42BPA0.46809241
88CAMK2A0.46468129
89EPHB20.45919989
90WNK10.44967012
91MAP2K10.44902175
92MAPK70.44520348
93RPS6KA20.44141254
94NTRK10.43800998
95RPS6KC10.43677274
96RPS6KL10.43677274
97DDR20.43504288
98MST1R0.42744230
99BRAF0.42340019
100PAK60.41165382
101MTOR0.40370882
102CDK70.40133527
103VRK20.39594500
104PTK20.39389864
105MAP2K20.38920571
106DAPK20.38137911
107DYRK1B0.37663470
108PRKACG0.37348081
109MAP3K90.37291731
110CDK80.37033905
111PRKD30.36611283
112MAP3K130.33507887
113PRKACA0.33412055
114RPS6KA10.32073620
115PRKG20.32018768
116PTK2B0.31850621
117ERBB40.31724789
118RET0.31429915
119FLT30.30696461
120MAP3K10.30198316
121MAPK40.29987371
122SGK30.29114504
123ZAK0.28720510
124PIM20.28088421
125KSR20.28082327
126MAP3K80.27950689
127BMX0.27942440
128SGK4940.27367158
129SGK2230.27367158
130RPS6KA60.26211082
131PAK20.25903295
132GRK70.25084087
133RPS6KB10.25075485
134PDK10.24770420
135RPS6KA30.24683995
136SGK10.24620968
137AURKA0.24618901
138MAP3K110.24615146
139MAPK100.24514095
140PRKG10.24373822
141PRKCE0.24281077
142FGFR10.24208112
143KDR0.23756508
144TTK0.23500547

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.78441040
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.40804893
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.29899933
4Fatty acid degradation_Homo sapiens_hsa000713.11404597
5Propanoate metabolism_Homo sapiens_hsa006403.09757253
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.83829737
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.58892786
8Nitrogen metabolism_Homo sapiens_hsa009102.55649377
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52636663
10Arginine biosynthesis_Homo sapiens_hsa002202.50635925
11Fatty acid metabolism_Homo sapiens_hsa012122.39509843
12Butanoate metabolism_Homo sapiens_hsa006502.17905973
13Carbon metabolism_Homo sapiens_hsa012002.10795527
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05933073
15Tryptophan metabolism_Homo sapiens_hsa003802.00694737
16Cardiac muscle contraction_Homo sapiens_hsa042601.99235394
17Pyruvate metabolism_Homo sapiens_hsa006201.92840619
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.92819753
19Dilated cardiomyopathy_Homo sapiens_hsa054141.89890447
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87660939
21PPAR signaling pathway_Homo sapiens_hsa033201.81794998
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72607000
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72347310
24Fatty acid elongation_Homo sapiens_hsa000621.66792375
25Peroxisome_Homo sapiens_hsa041461.59251926
26Biosynthesis of amino acids_Homo sapiens_hsa012301.56502819
27beta-Alanine metabolism_Homo sapiens_hsa004101.53097323
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51872738
29Starch and sucrose metabolism_Homo sapiens_hsa005001.51313951
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48435690
31Complement and coagulation cascades_Homo sapiens_hsa046101.33439070
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29870798
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28362175
34Arginine and proline metabolism_Homo sapiens_hsa003301.28356447
35Phenylalanine metabolism_Homo sapiens_hsa003601.27437023
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17403872
37Bile secretion_Homo sapiens_hsa049761.15691806
38Parkinsons disease_Homo sapiens_hsa050121.12739419
39Oxidative phosphorylation_Homo sapiens_hsa001901.08301330
40Tyrosine metabolism_Homo sapiens_hsa003501.06090699
41Chemical carcinogenesis_Homo sapiens_hsa052041.04288284
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02443700
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01451958
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01165882
45Thyroid cancer_Homo sapiens_hsa052161.00288330
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.98628891
47Histidine metabolism_Homo sapiens_hsa003400.96618052
48Fatty acid biosynthesis_Homo sapiens_hsa000610.96221392
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95088777
50Sulfur metabolism_Homo sapiens_hsa009200.93833909
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92568337
52Fat digestion and absorption_Homo sapiens_hsa049750.91096801
53Adherens junction_Homo sapiens_hsa045200.88763339
54Alzheimers disease_Homo sapiens_hsa050100.87342065
55Caffeine metabolism_Homo sapiens_hsa002320.87231802
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87085468
57Bladder cancer_Homo sapiens_hsa052190.85244247
58Lysine degradation_Homo sapiens_hsa003100.85171329
59Insulin resistance_Homo sapiens_hsa049310.83480238
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.82399891
61Glucagon signaling pathway_Homo sapiens_hsa049220.78566820
62Retinol metabolism_Homo sapiens_hsa008300.76208357
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75406031
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74729169
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.70630447
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67185808
67Proteoglycans in cancer_Homo sapiens_hsa052050.67141640
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66755325
69Insulin signaling pathway_Homo sapiens_hsa049100.65802175
70Small cell lung cancer_Homo sapiens_hsa052220.65420092
71Selenocompound metabolism_Homo sapiens_hsa004500.63418438
72ABC transporters_Homo sapiens_hsa020100.62920481
73Glioma_Homo sapiens_hsa052140.61215835
74Sulfur relay system_Homo sapiens_hsa041220.61178068
75VEGF signaling pathway_Homo sapiens_hsa043700.60427996
76Endometrial cancer_Homo sapiens_hsa052130.58956324
77AMPK signaling pathway_Homo sapiens_hsa041520.58833164
78GnRH signaling pathway_Homo sapiens_hsa049120.57312449
79Glycerolipid metabolism_Homo sapiens_hsa005610.56879839
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53446646
81Hippo signaling pathway_Homo sapiens_hsa043900.53283475
82Prion diseases_Homo sapiens_hsa050200.53233804
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52796714
84Fructose and mannose metabolism_Homo sapiens_hsa000510.52496418
85Chronic myeloid leukemia_Homo sapiens_hsa052200.52037779
86Amoebiasis_Homo sapiens_hsa051460.51605837
87mTOR signaling pathway_Homo sapiens_hsa041500.49872569
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49039034
89Galactose metabolism_Homo sapiens_hsa000520.47195025
90Melanogenesis_Homo sapiens_hsa049160.46319400
91Non-small cell lung cancer_Homo sapiens_hsa052230.45302966
92Pentose phosphate pathway_Homo sapiens_hsa000300.43497471
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.43091993
94Other glycan degradation_Homo sapiens_hsa005110.43008677
95Huntingtons disease_Homo sapiens_hsa050160.42757017
96Vitamin B6 metabolism_Homo sapiens_hsa007500.42668281
97Staphylococcus aureus infection_Homo sapiens_hsa051500.42635695
98Basal cell carcinoma_Homo sapiens_hsa052170.41944658
99Steroid biosynthesis_Homo sapiens_hsa001000.41890372
100Viral myocarditis_Homo sapiens_hsa054160.41707317
101Tight junction_Homo sapiens_hsa045300.41170406
102Metabolic pathways_Homo sapiens_hsa011000.41160248
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39425988
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39353310
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.37507566
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37137305
107Notch signaling pathway_Homo sapiens_hsa043300.35833206
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34800315
109Glutathione metabolism_Homo sapiens_hsa004800.33870921
110DNA replication_Homo sapiens_hsa030300.33707147
111Folate biosynthesis_Homo sapiens_hsa007900.33444589
112ErbB signaling pathway_Homo sapiens_hsa040120.33173223
113Renal cell carcinoma_Homo sapiens_hsa052110.33158659
114HIF-1 signaling pathway_Homo sapiens_hsa040660.32443831
115Focal adhesion_Homo sapiens_hsa045100.31933500
116Long-term potentiation_Homo sapiens_hsa047200.30637251
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30217011
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29268456
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28784008
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.27582986
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26013349
122Oxytocin signaling pathway_Homo sapiens_hsa049210.25463169
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.25002547
124Calcium signaling pathway_Homo sapiens_hsa040200.23733962
125Pancreatic cancer_Homo sapiens_hsa052120.23725644
126ECM-receptor interaction_Homo sapiens_hsa045120.23358566
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23178525
128Estrogen signaling pathway_Homo sapiens_hsa049150.23176603
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.22181386
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21189443
131Circadian rhythm_Homo sapiens_hsa047100.19442915
132Vitamin digestion and absorption_Homo sapiens_hsa049770.18798894
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17871565
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17009672
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.16206530
136Gastric acid secretion_Homo sapiens_hsa049710.15900748
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.14517257

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