PADI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.55356540
2axon ensheathment in central nervous system (GO:0032291)9.55356540
3axon ensheathment (GO:0008366)5.66376595
4ensheathment of neurons (GO:0007272)5.66376595
5myelination (GO:0042552)5.61546617
6myelin maintenance (GO:0043217)5.11822947
7actin-myosin filament sliding (GO:0033275)5.09757071
8muscle filament sliding (GO:0030049)5.09757071
9skeletal muscle contraction (GO:0003009)4.84572407
10creatine metabolic process (GO:0006600)4.72775443
11L-amino acid import (GO:0043092)4.57322018
12fatty acid elongation (GO:0030497)4.37136021
13positive regulation by symbiont of host defense response (GO:0052509)4.31234730
14modulation by symbiont of host defense response (GO:0052031)4.31234730
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.31234730
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.31234730
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.31234730
18modulation by symbiont of host immune response (GO:0052553)4.31234730
19regulation of skeletal muscle contraction (GO:0014819)4.30594516
20macrophage activation involved in immune response (GO:0002281)4.29382040
21regulation of relaxation of muscle (GO:1901077)4.14987809
22actin-mediated cell contraction (GO:0070252)4.05347235
23regulation of somitogenesis (GO:0014807)3.92238623
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.91517067
25detection of molecule of bacterial origin (GO:0032490)3.85753758
26oligodendrocyte differentiation (GO:0048709)3.77765895
27negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.76839742
28activated T cell proliferation (GO:0050798)3.73820166
29astrocyte development (GO:0014002)3.73756654
30regulation of collateral sprouting (GO:0048670)3.72142484
31leukocyte aggregation (GO:0070486)3.68074902
32auditory receptor cell differentiation (GO:0042491)3.66250949
33mast cell activation (GO:0045576)3.63452051
34striated muscle contraction (GO:0006941)3.62299127
35long-chain fatty acid biosynthetic process (GO:0042759)3.61778309
36response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.58928771
37glycine transport (GO:0015816)3.56112751
38negative regulation of neurotransmitter secretion (GO:0046929)3.55214880
39microglial cell activation (GO:0001774)3.55137659
40detection of other organism (GO:0098543)3.52839643
41interferon-gamma production (GO:0032609)3.49348388
42actin filament-based movement (GO:0030048)3.46561873
43amyloid precursor protein metabolic process (GO:0042982)3.45742292
44skeletal muscle adaptation (GO:0043501)3.43638339
45plasma membrane repair (GO:0001778)3.41671919
46detection of external biotic stimulus (GO:0098581)3.39946789
47amino acid import (GO:0043090)3.38465812
48response to inactivity (GO:0014854)3.36101132
49neutrophil activation involved in immune response (GO:0002283)3.35964559
50peptidyl-tyrosine autophosphorylation (GO:0038083)3.34119815
51skeletal muscle fiber development (GO:0048741)3.32831243
52photoreceptor cell differentiation (GO:0046530)3.31020147
53eye photoreceptor cell differentiation (GO:0001754)3.31020147
54mast cell activation involved in immune response (GO:0002279)3.28989932
55mast cell degranulation (GO:0043303)3.28989932
56negative regulation of protein localization to cell surface (GO:2000009)3.27461783
57import into cell (GO:0098657)3.27435863
58T cell migration (GO:0072678)3.24845677
59negative regulation of neurotransmitter transport (GO:0051589)3.24503437
60response to peptidoglycan (GO:0032494)3.23385901
61detection of bacterium (GO:0016045)3.23123792
62macrophage activation (GO:0042116)3.22295552
63positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.22106685
64peripheral nervous system axon ensheathment (GO:0032292)3.18563996
65myelination in peripheral nervous system (GO:0022011)3.18563996
66myofibril assembly (GO:0030239)3.17553532
67regulation of interferon-beta biosynthetic process (GO:0045357)3.13361274
68negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13063145
69negative regulation of cell killing (GO:0031342)3.13063145
70response to host immune response (GO:0052572)3.12818566
71response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.12818566
72leukocyte migration involved in inflammatory response (GO:0002523)3.09494126
73positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05669605
74regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05116948
75germinal center formation (GO:0002467)3.04933704
76positive regulation of gliogenesis (GO:0014015)3.04503846
77response to methylmercury (GO:0051597)3.03626422
78glycosylceramide metabolic process (GO:0006677)3.02792058
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.02134014
80membrane tubulation (GO:0097320)3.01567806
81response to host (GO:0075136)2.99498838
82response to host defenses (GO:0052200)2.99498838
83response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99498838
84antigen processing and presentation of endogenous antigen (GO:0019883)2.98473961
85potassium ion import (GO:0010107)2.97815154
86regulation of gamma-delta T cell activation (GO:0046643)2.95590436
87cellular response to interleukin-15 (GO:0071350)2.95427336
88regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.93385376
89detection of biotic stimulus (GO:0009595)2.92163775
90neuronal action potential propagation (GO:0019227)2.91450781
91regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.90243835
92regulation of natural killer cell mediated immunity (GO:0002715)2.90049559
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90049559
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.88250651
95glucan catabolic process (GO:0009251)2.86503966
96neutrophil activation (GO:0042119)2.86414298
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86077954
98cellular extravasation (GO:0045123)2.84777118
99cortical actin cytoskeleton organization (GO:0030866)2.84738174
100negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.83721941
101negative regulation of lymphocyte mediated immunity (GO:0002707)2.82322922
102myotube cell development (GO:0014904)2.81685908
103positive regulation of oligodendrocyte differentiation (GO:0048714)2.79055255
104cardiac muscle contraction (GO:0060048)2.78132386
105protein palmitoylation (GO:0018345)2.77845516
106negative T cell selection (GO:0043383)2.77695151
107cellular polysaccharide catabolic process (GO:0044247)2.77381914
108positive regulation of glial cell differentiation (GO:0045687)2.76456146
109Golgi to endosome transport (GO:0006895)2.75826617
110negative regulation of muscle contraction (GO:0045932)2.75073197
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.73714947
112response to lipoprotein particle (GO:0055094)2.73346679
113striated muscle atrophy (GO:0014891)2.73321320
114asymmetric protein localization (GO:0008105)2.73088811
115glycogen catabolic process (GO:0005980)2.73084878
116ear development (GO:0043583)2.72836412
117striated muscle adaptation (GO:0014888)2.69393083
118neurotransmitter uptake (GO:0001504)2.69386503
119regulation of B cell receptor signaling pathway (GO:0050855)2.69130940
120negative regulation of inclusion body assembly (GO:0090084)2.69045946
121myeloid cell activation involved in immune response (GO:0002275)2.68909566
122regulation of ARF protein signal transduction (GO:0032012)2.68899050
123positive regulation of myotube differentiation (GO:0010831)2.68706095
124regulation of mast cell degranulation (GO:0043304)2.67059058
125negative thymic T cell selection (GO:0045060)2.66335799
126positive regulation of astrocyte differentiation (GO:0048711)2.66334605
127regulation of macrophage cytokine production (GO:0010935)2.65827028
128* substantia nigra development (GO:0021762)2.65694193
129regulation of T-helper 2 cell differentiation (GO:0045628)2.65274270
130negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.65011433
131positive regulation of cellular amide metabolic process (GO:0034250)2.64249760
132response to interleukin-15 (GO:0070672)2.63755910
133regulation of leukocyte degranulation (GO:0043300)2.62770916
134response to muscle activity (GO:0014850)2.62572580
135adult walking behavior (GO:0007628)2.62445412
136tolerance induction (GO:0002507)2.62223229
137antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61524490
138negative regulation of macroautophagy (GO:0016242)2.60312554
139positive regulation of mast cell activation (GO:0033005)2.59990291
140cortical cytoskeleton organization (GO:0030865)2.59378674
141positive regulation of gamma-delta T cell activation (GO:0046645)2.59333513
142negative regulation of leukocyte mediated immunity (GO:0002704)2.59172277
143respiratory burst (GO:0045730)2.59132704
144regulation of regulated secretory pathway (GO:1903305)2.57973148
145production of molecular mediator involved in inflammatory response (GO:0002532)2.57574001
146muscle contraction (GO:0006936)2.54440299
147negative regulation of myotube differentiation (GO:0010832)2.54378718
148negative regulation of axonogenesis (GO:0050771)2.54096594
149nerve growth factor signaling pathway (GO:0038180)2.53813791
150negative regulation of erythrocyte differentiation (GO:0045647)2.53464861
151positive regulation of mast cell activation involved in immune response (GO:0033008)2.52983448
152positive regulation of mast cell degranulation (GO:0043306)2.52983448
153transmission of nerve impulse (GO:0019226)2.52882901
154amyloid precursor protein catabolic process (GO:0042987)2.52814889
155regulation of cell communication by electrical coupling (GO:0010649)2.52472808
156granulocyte activation (GO:0036230)2.51895861
157glial cell development (GO:0021782)2.51154908
158lysosome localization (GO:0032418)2.50704960
159negative regulation of interleukin-12 production (GO:0032695)2.49863734
160positive regulation of macrophage cytokine production (GO:0060907)2.49099692
161polysaccharide catabolic process (GO:0000272)2.48786967
162positive regulation of toll-like receptor signaling pathway (GO:0034123)2.48274227
163regulation of autophagic vacuole assembly (GO:2000785)2.42992331
164sarcoplasmic reticulum calcium ion transport (GO:0070296)2.39224520
165positive regulation of Rap GTPase activity (GO:0032854)2.38180624
166positive regulation of natural killer cell mediated immunity (GO:0002717)2.35814664
167positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.35814664
168regulation of gamma-delta T cell differentiation (GO:0045586)2.33860212
169presynaptic membrane organization (GO:0097090)2.33622361
170cyclic nucleotide catabolic process (GO:0009214)2.32595416
171regulation of extracellular matrix disassembly (GO:0010715)2.30364632
172neuronal ion channel clustering (GO:0045161)2.30042558
173glycerophospholipid catabolic process (GO:0046475)2.28809172
174protein localization to endosome (GO:0036010)2.28667357
175neuroblast proliferation (GO:0007405)2.28571659
176heterotypic cell-cell adhesion (GO:0034113)2.27485695
177regulation of lipoprotein metabolic process (GO:0050746)2.26761795
178interleukin-6-mediated signaling pathway (GO:0070102)2.26034483
179negative regulation of JUN kinase activity (GO:0043508)2.24553939
180regulation of Rap GTPase activity (GO:0032317)2.24108674
181peripheral nervous system development (GO:0007422)2.24030330
182negative regulation of execution phase of apoptosis (GO:1900118)2.23423670
183positive thymic T cell selection (GO:0045059)2.23388919
184adenosine receptor signaling pathway (GO:0001973)2.23252120
185apical protein localization (GO:0045176)2.23113001
186regulation of ARF GTPase activity (GO:0032312)2.22518666
187leukocyte degranulation (GO:0043299)2.21947943
188T cell receptor signaling pathway (GO:0050852)2.21433225
189glial cell differentiation (GO:0010001)2.21271247
190positive regulation of cell fate commitment (GO:0010455)2.20358576

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.00797629
2VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.46629531
3RUNX_20019798_ChIP-Seq_JUKART_Human2.91657640
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.83435874
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.71524779
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.59356043
7DROSHA_22980978_ChIP-Seq_HELA_Human2.50338258
8AR_21572438_ChIP-Seq_LNCaP_Human2.28625862
9STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99857618
10BP1_19119308_ChIP-ChIP_Hs578T_Human1.97058583
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.82550459
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82542460
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79938530
14SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79470575
15SCL_19346495_ChIP-Seq_HPC-7_Human1.77677620
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67952193
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65193158
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63486590
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63416266
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63210219
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60672609
22LXR_22292898_ChIP-Seq_THP-1_Human1.58759322
23MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58541043
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56890722
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56667501
26SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56628558
27NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.55359927
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54357059
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54192014
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54192014
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52692595
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.50637755
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.49617861
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.48964338
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47002167
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.45239025
37MYB_26560356_Chip-Seq_TH2_Human1.40964372
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40941313
39SPI1_23127762_ChIP-Seq_K562_Human1.39669233
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38292240
41KDM2B_26808549_Chip-Seq_DND41_Human1.36319553
42VDR_24787735_ChIP-Seq_THP-1_Human1.36049292
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.35729318
44TBX20_22328084_ChIP-Seq_HEART_Mouse1.33448107
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.33448107
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31428787
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30519066
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.30002903
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29865626
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28719699
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28540169
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.27940945
53VDR_24763502_ChIP-Seq_THP-1_Human1.27824271
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27309983
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.27225506
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24590455
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22783095
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20199564
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18819267
60GATA3_27048872_Chip-Seq_THYMUS_Human1.17943739
61SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17613917
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17388806
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15114636
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14438177
65GBX2_23144817_ChIP-Seq_PC3_Human1.14255743
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13709289
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13146048
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11379637
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10427139
70KDM2B_26808549_Chip-Seq_JURKAT_Human1.08716968
71GATA1_19941826_ChIP-Seq_K562_Human1.08532175
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07440333
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07157864
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07013734
75MAF_26560356_Chip-Seq_TH1_Human1.06676715
76GATA1_22025678_ChIP-Seq_K562_Human1.06107241
77RACK7_27058665_Chip-Seq_MCF-7_Human1.05973313
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05566851
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.04084481
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03801709
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03376520
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02942890
83ER_23166858_ChIP-Seq_MCF-7_Human1.02671921
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02558825
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.02303012
86VDR_21846776_ChIP-Seq_THP-1_Human1.02074611
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01433570
88KDM2B_26808549_Chip-Seq_K562_Human0.99909715
89* RUNX1_22412390_ChIP-Seq_EML_Mouse0.98804224
90ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97538981
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96394466
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96255386
93SMC4_20622854_ChIP-Seq_HELA_Human0.96100998
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95276325
95ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95248321
96EZH2_22144423_ChIP-Seq_EOC_Human0.95099797
97* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95091465
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94839527
99NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94395554
100PRDM14_20953172_ChIP-Seq_ESCs_Human0.94250570
101* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94216216
102EZH2_27304074_Chip-Seq_ESCs_Mouse0.93981664
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93573314
104AHR_22903824_ChIP-Seq_MCF-7_Human0.93489146
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93155408
106* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93143940
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92814815
108* OCT4_19829295_ChIP-Seq_ESCs_Human0.92782208
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92073160
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.91694105
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.91646014
112* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91613536
113GATA2_19941826_ChIP-Seq_K562_Human0.91602933
114* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90961381
115GATA1_19941827_ChIP-Seq_MEL86_Mouse0.90794093
116GATA1_19941827_ChIP-Seq_MEL_Mouse0.90384081
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.90306213
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90237071
119TCF7_22412390_ChIP-Seq_EML_Mouse0.89796621
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89481701
121STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89307667
122PU_27001747_Chip-Seq_BMDM_Mouse0.88615633
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88596322
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88319207
125NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88221257
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87855452
127* SPI1_23547873_ChIP-Seq_NB4_Human0.87175190
128UTX_26944678_Chip-Seq_JUKART_Human0.87145184
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85659313
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.85393052
131SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85248279
132* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84164550
133SPI1_20517297_ChIP-Seq_HL60_Human0.83762085
134PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83619526
135MYB_26560356_Chip-Seq_TH1_Human0.83227497
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83188279
137RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83137336
138EGR1_19032775_ChIP-ChIP_M12_Human0.83008953
139SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82048469
140* SA1_27219007_Chip-Seq_Bcells_Human0.81808316
141MAF_26560356_Chip-Seq_TH2_Human0.81466696
142IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81459867
143SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.80535561
144EED_16625203_ChIP-ChIP_MESCs_Mouse0.79515863
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.79384738
146LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78110993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination4.74010361
2MP0003646_muscle_fatigue3.93488810
3MP0001485_abnormal_pinna_reflex3.61831122
4MP0003690_abnormal_glial_cell3.34307981
5MP0003724_increased_susceptibility_to3.20423458
6MP0005451_abnormal_body_composition2.96837330
7MP0004885_abnormal_endolymph2.96600451
8MP0003950_abnormal_plasma_membrane2.93447557
9MP0004130_abnormal_muscle_cell2.79154400
10MP0005671_abnormal_response_to2.74504812
11MP0003303_peritoneal_inflammation2.50640675
12MP0004742_abnormal_vestibular_system2.48694925
13MP0001486_abnormal_startle_reflex2.47281964
14MP0004145_abnormal_muscle_electrophysio2.43704139
15MP0006082_CNS_inflammation2.41126320
16MP0002332_abnormal_exercise_endurance2.36381586
17MP0000383_abnormal_hair_follicle2.32491828
18MP0003436_decreased_susceptibility_to2.22626405
19MP0003880_abnormal_central_pattern2.16161289
20MP0005377_hearing/vestibular/ear_phenot2.15687951
21MP0003878_abnormal_ear_physiology2.15687951
22MP0003879_abnormal_hair_cell2.10773554
23MP0003329_amyloid_beta_deposits2.10505431
24MP0004087_abnormal_muscle_fiber2.08630337
25MP0003191_abnormal_cellular_cholesterol2.03424391
26MP0005171_absent_coat_pigmentation2.02754194
27MP0004859_abnormal_synaptic_plasticity2.01443631
28MP0010678_abnormal_skin_adnexa1.99746297
29MP0003634_abnormal_glial_cell1.98043754
30MP0004142_abnormal_muscle_tone1.95848663
31MP0002269_muscular_atrophy1.93591491
32MP0004270_analgesia1.92235887
33MP0002272_abnormal_nervous_system1.90211721
34MP0001963_abnormal_hearing_physiology1.90203723
35MP0008569_lethality_at_weaning1.85818442
36MP0000750_abnormal_muscle_regeneration1.79022044
37MP0004381_abnormal_hair_follicle1.78115919
38MP0000747_muscle_weakness1.76169941
39MP0002064_seizures1.73591896
40MP0000749_muscle_degeneration1.67611996
41MP0002229_neurodegeneration1.66739705
42MP0005620_abnormal_muscle_contractility1.60556517
43MP0003828_pulmonary_edema1.60076262
44MP0008260_abnormal_autophagy1.58252002
45MP0004484_altered_response_of1.51761147
46MP0001835_abnormal_antigen_presentation1.51534248
47MP0004134_abnormal_chest_morphology1.48898631
48MP0003136_yellow_coat_color1.48634292
49MP0005058_abnormal_lysosome_morphology1.45753334
50MP0001851_eye_inflammation1.44269255
51MP0005166_decreased_susceptibility_to1.44210971
52MP0003172_abnormal_lysosome_physiology1.43563785
53MP0005409_darkened_coat_color1.40010978
54MP0005423_abnormal_somatic_nervous1.39475058
55MP0009785_altered_susceptibility_to1.38790483
56MP0004233_abnormal_muscle_weight1.38261090
57MP0000026_abnormal_inner_ear1.38119175
58MP0005167_abnormal_blood-brain_barrier1.36552569
59MP0003633_abnormal_nervous_system1.34637382
60MP0003183_abnormal_peptide_metabolism1.33520884
61MP0001905_abnormal_dopamine_level1.31574740
62MP0009745_abnormal_behavioral_response1.31222001
63MP0001790_abnormal_immune_system1.30160743
64MP0005387_immune_system_phenotype1.30160743
65MP0003763_abnormal_thymus_physiology1.28767683
66MP0001533_abnormal_skeleton_physiology1.28705190
67MP0002420_abnormal_adaptive_immunity1.27462926
68MP0005330_cardiomyopathy1.26540489
69MP0004084_abnormal_cardiac_muscle1.25933639
70MP0003632_abnormal_nervous_system1.24487218
71MP0005000_abnormal_immune_tolerance1.24412692
72MP0003631_nervous_system_phenotype1.23874332
73MP0001819_abnormal_immune_cell1.23699525
74MP0000778_abnormal_nervous_system1.21956983
75MP0002723_abnormal_immune_serum1.20710196
76MP0000604_amyloidosis1.20667763
77MP0001800_abnormal_humoral_immune1.19216314
78MP0002972_abnormal_cardiac_muscle1.18378655
79MP0002971_abnormal_brown_adipose1.18148463
80MP0003635_abnormal_synaptic_transmissio1.18064782
81MP0005623_abnormal_meninges_morphology1.15317908
82MP0000465_gastrointestinal_hemorrhage1.14661445
83MP0002882_abnormal_neuron_morphology1.09317614
84MP0005310_abnormal_salivary_gland1.09305083
85MP0000955_abnormal_spinal_cord1.05476965
86MP0005464_abnormal_platelet_physiology1.05233171
87MP0002419_abnormal_innate_immunity1.03914114
88MP0003300_gastrointestinal_ulcer1.03901306
89MP0009333_abnormal_splenocyte_physiolog1.01925713
90MP0009278_abnormal_bone_marrow1.01686474
91MP0005551_abnormal_eye_electrophysiolog1.01671040
92MP0000733_abnormal_muscle_development0.99865803
93MP0003866_abnormal_defecation0.98840822
94MP0002452_abnormal_antigen_presenting0.97537240
95MP0002752_abnormal_somatic_nervous0.97152230
96MP0001529_abnormal_vocalization0.96776115
97MP0008874_decreased_physiological_sensi0.95754758
98MP0000685_abnormal_immune_system0.93896142
99MP0001986_abnormal_taste_sensitivity0.93840744
100MP0010630_abnormal_cardiac_muscle0.92495357
101MP0002066_abnormal_motor_capabilities/c0.92305894
102MP0002933_joint_inflammation0.91965985
103MP0009046_muscle_twitch0.90912396
104MP0000372_irregular_coat_pigmentation0.89943297
105MP0005025_abnormal_response_to0.89576186
106MP0000716_abnormal_immune_system0.89396154
107MP0001502_abnormal_circadian_rhythm0.89183577
108MP0002106_abnormal_muscle_physiology0.89123728
109MP0003448_altered_tumor_morphology0.87524315
110MP0002067_abnormal_sensory_capabilities0.86681144
111MP0005075_abnormal_melanosome_morpholog0.86208953
112MP0004883_abnormal_blood_vessel0.86179325
113MP0002277_abnormal_respiratory_mucosa0.86101037
114MP0002398_abnormal_bone_marrow0.84826145
115MP0005645_abnormal_hypothalamus_physiol0.83447490
116MP0001970_abnormal_pain_threshold0.82897519
117MP0002108_abnormal_muscle_morphology0.81491357
118MP0002998_abnormal_bone_remodeling0.81223437
119MP0001299_abnormal_eye_distance/0.78886297
120MP0005535_abnormal_body_temperature0.78835101
121MP0010155_abnormal_intestine_physiology0.78450750
122MP0002148_abnormal_hypersensitivity_rea0.78076213
123MP0004185_abnormal_adipocyte_glucose0.77983751
124MP0002405_respiratory_system_inflammati0.77252208
125MP0000759_abnormal_skeletal_muscle0.76965885
126MP0003705_abnormal_hypodermis_morpholog0.76934177
127MP0004510_myositis0.76774666
128MP0001873_stomach_inflammation0.76729145
129MP0000751_myopathy0.76345856
130MP0005666_abnormal_adipose_tissue0.76038945
131MP0002063_abnormal_learning/memory/cond0.75964946
132MP0005266_abnormal_metabolism0.75380664
133MP0004043_abnormal_pH_regulation0.75126224
134MP0002734_abnormal_mechanical_nocicepti0.74708659
135MP0001845_abnormal_inflammatory_respons0.74510184
136MP0000703_abnormal_thymus_morphology0.74434991
137MP0003075_altered_response_to0.73891301
138MP0004036_abnormal_muscle_relaxation0.73637749
139MP0003045_fibrosis0.73610508
140MP0006036_abnormal_mitochondrial_physio0.73543270
141MP0002132_abnormal_respiratory_system0.73476888
142MP0003656_abnormal_erythrocyte_physiolo0.73460624
143MP0004147_increased_porphyrin_level0.71870292
144MP0001765_abnormal_ion_homeostasis0.71484080
145MP0004947_skin_inflammation0.71039515
146MP0004924_abnormal_behavior0.70872005
147MP0005386_behavior/neurological_phenoty0.70872005
148MP0004858_abnormal_nervous_system0.70329917
149MP0005369_muscle_phenotype0.68626743
150MP0005385_cardiovascular_system_phenoty0.65094609
151MP0001544_abnormal_cardiovascular_syste0.65094609
152MP0008469_abnormal_protein_level0.64802831

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)5.88468045
2Peripheral hypomyelination (HP:0007182)4.73423838
3Neurofibrillary tangles (HP:0002185)4.41614728
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.26390872
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.26390872
6Supranuclear gaze palsy (HP:0000605)4.09550743
7Slow saccadic eye movements (HP:0000514)3.93626629
8Abnormal auditory evoked potentials (HP:0006958)3.91173694
9Onion bulb formation (HP:0003383)3.89402360
10Muscle fiber inclusion bodies (HP:0100299)3.70738840
11Cerebral hypomyelination (HP:0006808)3.69200408
12Increased connective tissue (HP:0009025)3.67198331
13Abnormality of skeletal muscle fiber size (HP:0012084)3.63552267
14Nemaline bodies (HP:0003798)3.54660864
15Exercise-induced myalgia (HP:0003738)3.54176531
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.52645420
17Ulnar deviation of the wrist (HP:0003049)3.47205748
18Rhabdomyolysis (HP:0003201)3.42838261
19Abnormality of the left ventricular outflow tract (HP:0011103)3.40978877
20Subaortic stenosis (HP:0001682)3.40978877
21Eczematoid dermatitis (HP:0000976)3.38416703
22Ankle clonus (HP:0011448)3.26793196
23Increased variability in muscle fiber diameter (HP:0003557)3.21973574
24Distal lower limb muscle weakness (HP:0009053)3.16696646
25Myoglobinuria (HP:0002913)3.14405253
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.11317557
27Frequent falls (HP:0002359)3.05999855
28Muscle hypertrophy of the lower extremities (HP:0008968)3.03786119
29Premature skin wrinkling (HP:0100678)2.98408322
30Cerebral inclusion bodies (HP:0100314)2.96413550
31Spastic gait (HP:0002064)2.91252385
32Sensory axonal neuropathy (HP:0003390)2.86543214
33Parakeratosis (HP:0001036)2.85418177
34Abnormality of the corticospinal tract (HP:0002492)2.84644320
35Intention tremor (HP:0002080)2.82896511
36Dysmetria (HP:0001310)2.82785683
37Alacrima (HP:0000522)2.82300675
38Morphological abnormality of the inner ear (HP:0011390)2.81124851
39Exercise-induced muscle cramps (HP:0003710)2.80479100
40Abnormality of the calf musculature (HP:0001430)2.77908353
41Asymmetric septal hypertrophy (HP:0001670)2.77043925
42EMG: neuropathic changes (HP:0003445)2.75402922
43Fetal akinesia sequence (HP:0001989)2.74984569
44Bundle branch block (HP:0011710)2.68513069
45Orchitis (HP:0100796)2.67793534
46Myositis (HP:0100614)2.67281674
47Segmental peripheral demyelination/remyelination (HP:0003481)2.62508234
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.62311118
49Malignant hyperthermia (HP:0002047)2.60868941
50Epiphyseal dysplasia (HP:0002656)2.60762838
51Recurrent bacterial skin infections (HP:0005406)2.59793958
52Areflexia of lower limbs (HP:0002522)2.54031242
53T lymphocytopenia (HP:0005403)2.53357371
54Myopathic facies (HP:0002058)2.52917748
55Bulbar palsy (HP:0001283)2.52906596
56White forelock (HP:0002211)2.51602584
57Round ear (HP:0100830)2.50257618
58Hyperkalemia (HP:0002153)2.48900014
59Hypoplastic ischia (HP:0003175)2.48456355
60Difficulty running (HP:0009046)2.46996505
61Akinesia (HP:0002304)2.44216230
62Clumsiness (HP:0002312)2.43736464
63Abnormality of binocular vision (HP:0011514)2.41357456
64Diplopia (HP:0000651)2.41357456
65Sudden death (HP:0001699)2.40850785
66Stridor (HP:0010307)2.39354926
67Abnormality of glycolipid metabolism (HP:0010969)2.35089067
68Abnormality of liposaccharide metabolism (HP:0010968)2.35089067
69Abnormality of glycosphingolipid metabolism (HP:0004343)2.35089067
70Stomatitis (HP:0010280)2.33495866
71Distal lower limb amyotrophy (HP:0008944)2.33061700
72Patchy hypopigmentation of hair (HP:0011365)2.32867327
73Decreased lacrimation (HP:0000633)2.32757121
74Muscle fiber splitting (HP:0003555)2.32572811
75Absent phalangeal crease (HP:0006109)2.31931140
76Bell-shaped thorax (HP:0001591)2.27314466
77Gowers sign (HP:0003391)2.25754711
78Abnormality of T cell number (HP:0011839)2.25748618
79Calf muscle hypertrophy (HP:0008981)2.25481805
80Hemiplegia (HP:0002301)2.25233445
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.24712168
82Increased cerebral lipofuscin (HP:0011813)2.24229291
83Generalized muscle weakness (HP:0003324)2.22034573
84Rimmed vacuoles (HP:0003805)2.19823023
85Hyporeflexia of lower limbs (HP:0002600)2.18501679
86Ventricular fibrillation (HP:0001663)2.18198648
87Optic neuritis (HP:0100653)2.16953234
88Retrobulbar optic neuritis (HP:0100654)2.16953234
89Calcaneovalgus deformity (HP:0001848)2.16950906
90Distal arthrogryposis (HP:0005684)2.16199168
91Mixed hearing impairment (HP:0000410)2.16019025
92Recurrent gram-negative bacterial infections (HP:0005420)2.15724830
93Chronic otitis media (HP:0000389)2.13966342
94Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.13668263
95Bowel incontinence (HP:0002607)2.13354333
96Myotonia (HP:0002486)2.11273658
97Scanning speech (HP:0002168)2.10863628
98Muscle stiffness (HP:0003552)2.10835591
99Urinary urgency (HP:0000012)2.10471415
100Hypoplasia of the iris (HP:0007676)2.09980761
101Anomalous pulmonary venous return (HP:0010772)2.08987420
102Abnormality of the ischium (HP:0003174)2.08766858
103Postural instability (HP:0002172)2.07701615
104Weak cry (HP:0001612)2.06347792
105Obstructive sleep apnea (HP:0002870)2.05911231
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04652667
107Abnormality of macrophages (HP:0004311)2.04017807
108Chest pain (HP:0100749)2.03388669
109Congenital sensorineural hearing impairment (HP:0008527)2.03038440
110Abnormal large intestine physiology (HP:0012700)2.02252693
111Ventricular arrhythmia (HP:0004308)1.97586779
112Gastrointestinal infarctions (HP:0005244)1.97241657
113Lower limb amyotrophy (HP:0007210)1.97046772
114Rapidly progressive (HP:0003678)1.96294382
115Foot dorsiflexor weakness (HP:0009027)1.95077869
116Increased CSF protein (HP:0002922)1.93920228
117Nonprogressive disorder (HP:0003680)1.90244889
118Hypoproteinemia (HP:0003075)1.89573309
119Abnormal finger flexion creases (HP:0006143)1.89460993
120CNS hypomyelination (HP:0003429)1.89025886
121EMG: myopathic abnormalities (HP:0003458)1.88629249
122Axonal loss (HP:0003447)1.86233959
123Mediastinal lymphadenopathy (HP:0100721)1.85658112
124Abnormality of saccadic eye movements (HP:0000570)1.85306025
125Absent septum pellucidum (HP:0001331)1.84968894
126Spontaneous hematomas (HP:0007420)1.83580361
127Difficulty climbing stairs (HP:0003551)1.82651035
128Scapular winging (HP:0003691)1.82079368
129Abnormality of the neuromuscular junction (HP:0003398)1.81008245
130Fatigable weakness (HP:0003473)1.81008245
131Deformed tarsal bones (HP:0008119)1.80978721
132Poor speech (HP:0002465)1.80917320
133Slender build (HP:0001533)1.80055066
134Panhypogammaglobulinemia (HP:0003139)1.80021904
135Gingivitis (HP:0000230)1.79568484
136Recurrent fungal infections (HP:0002841)1.77391052
137Heart block (HP:0012722)1.77320298
138Abnormality of the foot musculature (HP:0001436)1.77248598
139Neck muscle weakness (HP:0000467)1.77140017
140Urinary incontinence (HP:0000020)1.77036902
141Paraparesis (HP:0002385)1.75492965
142Amyloidosis (HP:0011034)1.75492751
143Increased IgE level (HP:0003212)1.75045606
144Waddling gait (HP:0002515)1.75009006
145Metabolic alkalosis (HP:0200114)1.74171346
146Spastic paraparesis (HP:0002313)1.73409859
147Neuronal loss in central nervous system (HP:0002529)1.73025698
148Obstructive lung disease (HP:0006536)1.72697206
149Chronic obstructive pulmonary disease (HP:0006510)1.72697206
150Ventricular tachycardia (HP:0004756)1.72600387
151Anteriorly placed anus (HP:0001545)1.71810596
152Mildly elevated creatine phosphokinase (HP:0008180)1.71296696
153Abnormality of the endocardium (HP:0004306)1.70748199
154Increased circulating renin level (HP:0000848)1.70079539
155Loss of speech (HP:0002371)1.69811636
156Episodic fever (HP:0001954)1.69759379
157Elevated erythrocyte sedimentation rate (HP:0003565)1.69678257
158Recurrent abscess formation (HP:0002722)1.69186892
159Recurrent skin infections (HP:0001581)1.69133109
160Facial diplegia (HP:0001349)1.67976271
161Meningitis (HP:0001287)1.67843255
162Rigidity (HP:0002063)1.67749641
163Keratoconjunctivitis sicca (HP:0001097)1.67644907
164Hypochromic microcytic anemia (HP:0004840)1.65247889
165Easy fatigability (HP:0003388)1.63955021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.36242395
2EPHB14.26036456
3RIPK43.46403328
4TXK3.35579628
5OXSR12.81553306
6MAP2K32.70857469
7CLK12.47606741
8MAPKAPK52.27026848
9PKN12.22771255
10NEK62.13827711
11WNK12.08879612
12MAP4K12.02315728
13PHKG11.86882283
14PHKG21.86882283
15UHMK11.80029231
16TNIK1.77848656
17ROCK21.72841204
18TYK21.72316405
19ITK1.70901197
20CDK191.68901350
21ERN11.66009077
22TRPM71.65153817
23KSR21.63543810
24TESK21.62651512
25FGFR21.61665911
26PRPF4B1.60023764
27TNK21.59276295
28TRIB31.55896469
29OBSCN1.50356838
30LIMK11.46973017
31CSNK1A1L1.45960989
32RIPK11.42493314
33FES1.41646419
34SGK2231.36815715
35SGK4941.36815715
36DAPK21.29618683
37PINK11.29343422
38MAP3K11.28513406
39MAP2K41.26493301
40DDR21.25779945
41CSNK1G31.24403246
42MAP3K111.23587467
43TAOK11.23075352
44MAP3K31.21006030
45SGK31.18041473
46PRKCH1.17934852
47JAK21.17933371
48PRKCQ1.13936094
49JAK11.13289048
50GRK71.12656071
51FGR1.09646240
52CAMK2B1.09369512
53BLK1.08718170
54MAP3K71.06893330
55DMPK1.05091230
56WNK41.05037791
57ICK1.03190237
58SGK21.02703037
59MAP3K131.00706287
60TYRO30.98415945
61BMX0.98074331
62MAPK150.96654252
63NTRK30.96069618
64EEF2K0.95051185
65CSNK1G10.91824232
66GRK60.91234487
67STK100.90916832
68MARK20.89548523
69MAP2K60.88152888
70LCK0.87632037
71CSNK1G20.87238718
72MAP3K20.87114196
73NTRK20.85611910
74ADRBK20.83479545
75JAK30.83362381
76MET0.83046094
77BCR0.82449039
78NME10.81334467
79IRAK40.78929791
80KIT0.78724198
81TBK10.78262266
82CAMK1G0.75803991
83NTRK10.75454014
84PIK3CA0.73727930
85PDK10.71908366
86SIK10.71896474
87CSK0.71822032
88HCK0.71813567
89MST40.71386551
90PTK60.70695312
91PRKAA20.70032457
92PDPK10.69730427
93CAMK2D0.67696936
94PRKD10.67688543
95CDK50.66617818
96CAMK40.66367769
97IRAK20.66152602
98CAMK2G0.65674242
99BTK0.65412475
100MOS0.64512163
101STK380.63689139
102ALK0.62897942
103FYN0.62041675
104CAMK10.61825546
105MARK10.61631124
106RET0.61629742
107YES10.61130968
108PAK60.61107590
109HIPK20.60753386
110PIK3CG0.60293095
111ZAP700.60181871
112DYRK1B0.58154855
113TTN0.57195368
114CSF1R0.56676881
115CAMKK10.56622922
116MAP3K60.55956296
117PDGFRB0.55651021
118CDC42BPA0.53860258
119MAPK120.52819134
120TGFBR20.52310457
121PTK2B0.52175283
122SGK10.49950412
123EPHA30.48748547
124PRKG20.47124360
125MAPK100.45411286
126PNCK0.45356567
127FGFR30.44713156
128SYK0.44058076
129IRAK10.44047887
130MAP3K140.43965283
131MAP2K10.43767355
132PRKD20.43400734
133KSR10.41690143
134MAPK40.41446076
135CSNK1D0.41347685
136TAOK20.40515811
137CDK140.40318060
138IRAK30.36884889
139PBK0.36876155
140MUSK0.36826539
141MAPK130.35918015
142CDK150.34558684
143IKBKE0.34432838
144LYN0.34299783
145MAPK70.33502807
146PRKG10.33445478
147LRRK20.32849000
148STK110.31935452

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.95241985
2Autoimmune thyroid disease_Homo sapiens_hsa053202.29523457
3Allograft rejection_Homo sapiens_hsa053302.25593698
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.22764305
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19032341
6Steroid biosynthesis_Homo sapiens_hsa001001.97028215
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95518114
8Ether lipid metabolism_Homo sapiens_hsa005651.86921920
9Staphylococcus aureus infection_Homo sapiens_hsa051501.85666735
10Pancreatic secretion_Homo sapiens_hsa049721.82654522
11Primary immunodeficiency_Homo sapiens_hsa053401.79425112
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74895649
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.70619492
14Long-term potentiation_Homo sapiens_hsa047201.68017334
15Fatty acid elongation_Homo sapiens_hsa000621.67370472
16T cell receptor signaling pathway_Homo sapiens_hsa046601.65358911
17Tuberculosis_Homo sapiens_hsa051521.60643776
18Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.56798352
19GnRH signaling pathway_Homo sapiens_hsa049121.46244370
20B cell receptor signaling pathway_Homo sapiens_hsa046621.36900941
21Axon guidance_Homo sapiens_hsa043601.34127049
22Renal cell carcinoma_Homo sapiens_hsa052111.32436394
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.29341690
24Endocytosis_Homo sapiens_hsa041441.28478534
25Insulin signaling pathway_Homo sapiens_hsa049101.27777488
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27058114
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23842190
28Lysosome_Homo sapiens_hsa041421.21359762
29Chemokine signaling pathway_Homo sapiens_hsa040621.19226056
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19208730
31Gastric acid secretion_Homo sapiens_hsa049711.14577406
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13361006
33Sphingolipid signaling pathway_Homo sapiens_hsa040711.12583141
34Asthma_Homo sapiens_hsa053101.12506458
35Osteoclast differentiation_Homo sapiens_hsa043801.08356480
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08126937
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08031105
38Dorso-ventral axis formation_Homo sapiens_hsa043201.07030494
39Acute myeloid leukemia_Homo sapiens_hsa052211.06275328
40Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05350294
41Insulin resistance_Homo sapiens_hsa049311.04618173
42Morphine addiction_Homo sapiens_hsa050321.04287292
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.03489468
44Glucagon signaling pathway_Homo sapiens_hsa049221.03471251
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03404669
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02739050
47Sphingolipid metabolism_Homo sapiens_hsa006001.01768347
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01630132
49Glutamatergic synapse_Homo sapiens_hsa047241.01016414
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.99882586
51Non-small cell lung cancer_Homo sapiens_hsa052230.99037074
52Circadian rhythm_Homo sapiens_hsa047100.98952471
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.97458890
54GABAergic synapse_Homo sapiens_hsa047270.97448272
55Viral myocarditis_Homo sapiens_hsa054160.96259699
56Estrogen signaling pathway_Homo sapiens_hsa049150.94380404
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94023203
58Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93043448
59Inositol phosphate metabolism_Homo sapiens_hsa005620.92708398
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91502903
61Insulin secretion_Homo sapiens_hsa049110.91448622
62Notch signaling pathway_Homo sapiens_hsa043300.89985092
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89311600
64Synaptic vesicle cycle_Homo sapiens_hsa047210.88984734
65Type I diabetes mellitus_Homo sapiens_hsa049400.88128307
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86266805
67Ras signaling pathway_Homo sapiens_hsa040140.86205264
68Histidine metabolism_Homo sapiens_hsa003400.86124713
69Other glycan degradation_Homo sapiens_hsa005110.86121471
70Antigen processing and presentation_Homo sapiens_hsa046120.85565320
71Legionellosis_Homo sapiens_hsa051340.83844963
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.83370368
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83001114
74Platelet activation_Homo sapiens_hsa046110.82750695
75MAPK signaling pathway_Homo sapiens_hsa040100.82295826
76ErbB signaling pathway_Homo sapiens_hsa040120.80704662
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80669992
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80406871
79Protein digestion and absorption_Homo sapiens_hsa049740.80291029
80Hematopoietic cell lineage_Homo sapiens_hsa046400.79845692
81Tight junction_Homo sapiens_hsa045300.78502013
82Glioma_Homo sapiens_hsa052140.78244230
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77555491
84Pertussis_Homo sapiens_hsa051330.77400112
85Prolactin signaling pathway_Homo sapiens_hsa049170.77388064
86FoxO signaling pathway_Homo sapiens_hsa040680.75357752
87Cholinergic synapse_Homo sapiens_hsa047250.74957555
88Olfactory transduction_Homo sapiens_hsa047400.74942096
89Amphetamine addiction_Homo sapiens_hsa050310.74753785
90Malaria_Homo sapiens_hsa051440.74545669
91Serotonergic synapse_Homo sapiens_hsa047260.74426586
92Toxoplasmosis_Homo sapiens_hsa051450.73865426
93Cardiac muscle contraction_Homo sapiens_hsa042600.73663496
94Phagosome_Homo sapiens_hsa041450.73429218
95Oxytocin signaling pathway_Homo sapiens_hsa049210.71929702
96Choline metabolism in cancer_Homo sapiens_hsa052310.71810308
97VEGF signaling pathway_Homo sapiens_hsa043700.71117523
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70572051
99Long-term depression_Homo sapiens_hsa047300.70456329
100Measles_Homo sapiens_hsa051620.70356204
101Leishmaniasis_Homo sapiens_hsa051400.70056310
102Pancreatic cancer_Homo sapiens_hsa052120.69468349
103Endometrial cancer_Homo sapiens_hsa052130.69358202
104Nitrogen metabolism_Homo sapiens_hsa009100.69279417
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.69102748
106Salivary secretion_Homo sapiens_hsa049700.68576433
107Cocaine addiction_Homo sapiens_hsa050300.67732239
108Dopaminergic synapse_Homo sapiens_hsa047280.67548904
109AMPK signaling pathway_Homo sapiens_hsa041520.66613397
110Influenza A_Homo sapiens_hsa051640.66468917
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66284813
112Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65664220
113HIF-1 signaling pathway_Homo sapiens_hsa040660.64831549
114Calcium signaling pathway_Homo sapiens_hsa040200.64710991
115Rheumatoid arthritis_Homo sapiens_hsa053230.63284788
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62597722
117cAMP signaling pathway_Homo sapiens_hsa040240.62222761
118Circadian entrainment_Homo sapiens_hsa047130.62188472
119Hepatitis C_Homo sapiens_hsa051600.61749238
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61320951
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61299606
122African trypanosomiasis_Homo sapiens_hsa051430.61277054
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60726590
124Dilated cardiomyopathy_Homo sapiens_hsa054140.60558306
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60219681
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58999760
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58347976
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.57542231
129Linoleic acid metabolism_Homo sapiens_hsa005910.57166146
130Vascular smooth muscle contraction_Homo sapiens_hsa042700.56432790
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54896689
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.54587893
133Salmonella infection_Homo sapiens_hsa051320.54205332
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.53953537
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53807886
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53664118
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53631717
138Rap1 signaling pathway_Homo sapiens_hsa040150.53300557
139Chronic myeloid leukemia_Homo sapiens_hsa052200.53134596
140Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52849685
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52657163
142Shigellosis_Homo sapiens_hsa051310.52456284
143Renin secretion_Homo sapiens_hsa049240.51813521

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