PADI3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.64357466
2virion attachment to host cell (GO:0019062)8.45028997
3adhesion of symbiont to host cell (GO:0044650)8.45028997
4response to nitrosative stress (GO:0051409)7.71972295
5peptide cross-linking (GO:0018149)7.62490681
6hair follicle morphogenesis (GO:0031069)7.40447384
7adhesion of symbiont to host (GO:0044406)7.16085986
8one-carbon compound transport (GO:0019755)6.82578703
9xenobiotic catabolic process (GO:0042178)6.57256118
10intermediate filament cytoskeleton organization (GO:0045104)5.96811519
11cell wall macromolecule catabolic process (GO:0016998)5.93938279
12cell wall macromolecule metabolic process (GO:0044036)5.93938279
13keratinocyte differentiation (GO:0030216)5.77225925
14intermediate filament-based process (GO:0045103)5.74919888
15epidermis development (GO:0008544)5.72445417
16hemidesmosome assembly (GO:0031581)5.49424307
17establishment of skin barrier (GO:0061436)5.46805671
18molting cycle process (GO:0022404)5.03785836
19hair cycle process (GO:0022405)5.03785836
20activation of Rac GTPase activity (GO:0032863)4.93983372
21regulation of water loss via skin (GO:0033561)4.85600108
22positive regulation of Cdc42 GTPase activity (GO:0043089)4.83939410
23bundle of His cell to Purkinje myocyte communication (GO:0086069)4.80158019
24branching involved in mammary gland duct morphogenesis (GO:0060444)4.76556194
25COPI coating of Golgi vesicle (GO:0048205)4.59507484
26Golgi transport vesicle coating (GO:0048200)4.59507484
27epidermal cell differentiation (GO:0009913)4.36623481
28lung epithelium development (GO:0060428)4.36038228
29epithelial cell differentiation involved in prostate gland development (GO:0060742)4.19719427
30establishment of tissue polarity (GO:0007164)4.19514286
31establishment of planar polarity (GO:0001736)4.19514286
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.13402869
33skin morphogenesis (GO:0043589)4.10357453
34molting cycle (GO:0042303)31.4587320
35hair cycle (GO:0042633)31.4587320
36response to water (GO:0009415)3.93198995
37keratinocyte proliferation (GO:0043616)3.88596051
38face development (GO:0060324)3.88517179
39response to phenylpropanoid (GO:0080184)3.69275775
40atrioventricular valve morphogenesis (GO:0003181)3.68879954
41surfactant homeostasis (GO:0043129)3.66374278
42polarized epithelial cell differentiation (GO:0030859)3.61296123
43semaphorin-plexin signaling pathway (GO:0071526)3.61041633
44keratinocyte development (GO:0003334)3.60707800
45positive regulation of keratinocyte differentiation (GO:0045618)3.59141375
46negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.56132354
47negative regulation of keratinocyte proliferation (GO:0010839)3.55314015
48eyelid development in camera-type eye (GO:0061029)3.54599582
49mammary gland epithelial cell differentiation (GO:0060644)3.47645996
50ear development (GO:0043583)3.46550594
51mesodermal cell differentiation (GO:0048333)3.45549333
52regulation of Cdc42 GTPase activity (GO:0043088)3.42373611
53regulation of clathrin-mediated endocytosis (GO:2000369)3.36246215
54glutathione derivative metabolic process (GO:1901685)3.34807656
55glutathione derivative biosynthetic process (GO:1901687)3.34807656
56intestinal epithelial cell development (GO:0060576)3.31776554
57positive regulation of hair follicle development (GO:0051798)3.28055624
58positive regulation of hair cycle (GO:0042635)3.28055624
59hair follicle development (GO:0001942)3.25068460
60glutathione biosynthetic process (GO:0006750)3.23330624
61tooth mineralization (GO:0034505)3.20897666
62receptor recycling (GO:0001881)3.20260187
63proline biosynthetic process (GO:0006561)3.18151909
64flavonoid metabolic process (GO:0009812)3.18141642
65cyclooxygenase pathway (GO:0019371)3.17855367
66regulation of keratinocyte differentiation (GO:0045616)3.17725071
67cellular glucuronidation (GO:0052695)3.17517978
68regulation of hair follicle development (GO:0051797)3.12631637
69regulation of ruffle assembly (GO:1900027)3.11050827
70mammary gland epithelial cell proliferation (GO:0033598)3.09408909
71prostanoid metabolic process (GO:0006692)3.07656300
72prostaglandin metabolic process (GO:0006693)3.07656300
73renal system development (GO:0072001)3.07624351
74regulation of endothelial cell chemotaxis (GO:2001026)3.07043316
75diol metabolic process (GO:0034311)3.05762497
76multicellular organismal water homeostasis (GO:0050891)3.04674228
77alditol phosphate metabolic process (GO:0052646)3.04272756
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03982419
79negative regulation of kidney development (GO:0090185)3.01553865
80morphogenesis of embryonic epithelium (GO:0016331)2.99432471
81endothelial cell chemotaxis (GO:0035767)2.98293279
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.94202586
83glucuronate metabolic process (GO:0019585)2.92143259
84uronic acid metabolic process (GO:0006063)2.92143259
85regulation of hair cycle (GO:0042634)2.90127016
86positive regulation of epidermis development (GO:0045684)2.88278103
87nonribosomal peptide biosynthetic process (GO:0019184)2.87564725
88focal adhesion assembly (GO:0048041)2.86912024
89cell-substrate adherens junction assembly (GO:0007045)2.86912024
90cranial suture morphogenesis (GO:0060363)2.86587764
91negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.85586882
92protein localization to endosome (GO:0036010)2.82111779
93mesonephros development (GO:0001823)2.81601333
94sphingosine metabolic process (GO:0006670)2.81360106
95glucose catabolic process (GO:0006007)2.81305048
96Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.79861672
97cell differentiation involved in embryonic placenta development (GO:0060706)2.79525471
98cytoskeletal anchoring at plasma membrane (GO:0007016)2.77890101
99maternal placenta development (GO:0001893)2.77547364
100lipoxygenase pathway (GO:0019372)2.72703509
101regulation of lamellipodium assembly (GO:0010591)2.72479057
102epithelium development (GO:0060429)2.71427079
103establishment of apical/basal cell polarity (GO:0035089)2.70184008
104negative regulation of cell fate specification (GO:0009996)2.69874110
105phosphatidylinositol acyl-chain remodeling (GO:0036149)2.69462356
106sodium ion homeostasis (GO:0055078)2.69389363
107regulation of establishment of planar polarity (GO:0090175)2.68074943
108gap junction assembly (GO:0016264)2.65996845
109positive regulation of meiotic cell cycle (GO:0051446)2.63811989
110regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.57857610
111ectoderm development (GO:0007398)2.57698829
112bone trabecula formation (GO:0060346)2.51313819
113phosphatidylserine acyl-chain remodeling (GO:0036150)2.50408355
114epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.50034082
115negative regulation of erythrocyte differentiation (GO:0045647)2.44285297
116positive regulation of monocyte chemotaxis (GO:0090026)2.41634005
117regulation of epidermis development (GO:0045682)2.40271454
118wound healing, spreading of epidermal cells (GO:0035313)2.40012002
119negative regulation of protein localization to plasma membrane (GO:1903077)2.39853609
120positive regulation of epidermal cell differentiation (GO:0045606)2.39022205
121regulation of epidermal cell differentiation (GO:0045604)2.38086793
122water homeostasis (GO:0030104)2.32333710
123regulation of mesenchymal cell apoptotic process (GO:2001053)2.26402437
124granulocyte differentiation (GO:0030851)2.18904994
125outflow tract septum morphogenesis (GO:0003148)2.14399705
126negative regulation of skeletal muscle tissue development (GO:0048642)2.13744221
127cell surface receptor signaling pathway involved in heart development (GO:0061311)2.12570252
128* citrulline biosynthetic process (GO:0019240)2.10818081
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.09177001
130embryonic camera-type eye development (GO:0031076)2.06084048
131response to UV-B (GO:0010224)2.04264872
132regulation of keratinocyte proliferation (GO:0010837)2.03137147
133negative regulation of epidermis development (GO:0045683)2.01975732
134cell-substrate junction assembly (GO:0007044)2.01686838
135aging (GO:0007568)2.00431403
136intermediate filament organization (GO:0045109)11.0372125
137keratinization (GO:0031424)10.1557002
138phosphatidylglycerol acyl-chain remodeling (GO:0036148)1.99315114
139regulation of erythrocyte differentiation (GO:0045646)1.96690455
140regulation of cardioblast differentiation (GO:0051890)1.93662682
141oocyte development (GO:0048599)1.93340469
142skin development (GO:0043588)1.89314180
143negative regulation of transcription regulatory region DNA binding (GO:2000678)1.89028100
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)1.88760503
145phosphatidylethanolamine acyl-chain remodeling (GO:0036152)1.85028082
146negative regulation of cardiac muscle hypertrophy (GO:0010614)1.83365730
147positive regulation of erythrocyte differentiation (GO:0045648)1.81849402
148negative regulation of stress fiber assembly (GO:0051497)1.81053893
149cardiac right ventricle morphogenesis (GO:0003215)1.79964176
150apoptotic process involved in morphogenesis (GO:0060561)1.78981360
151negative regulation of stem cell proliferation (GO:2000647)1.73622334
152negative regulation of muscle hypertrophy (GO:0014741)1.72781411
153non-canonical Wnt signaling pathway (GO:0035567)1.71641324
154pore complex assembly (GO:0046931)1.71052670
155craniofacial suture morphogenesis (GO:0097094)1.69539085
156megakaryocyte development (GO:0035855)1.69205541
157lymph vessel development (GO:0001945)1.68230271
158interferon-gamma secretion (GO:0072643)1.68065191
159positive regulation of protein export from nucleus (GO:0046827)1.67543195
160formation of translation preinitiation complex (GO:0001731)1.66414155
161cellular component disassembly involved in execution phase of apoptosis (GO:0006921)1.66372050
162epithelial cell-cell adhesion (GO:0090136)1.65644509
163regulation of translational termination (GO:0006449)1.63761815
164signal transduction in absence of ligand (GO:0038034)1.62118804
165extrinsic apoptotic signaling pathway in absence of ligand (GO:0097192)1.62118804
166phosphatidylserine metabolic process (GO:0006658)1.61908906
167regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901211.61731806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat7.22865124
2E2F7_22180533_ChIP-Seq_HELA_Human4.56646758
3ZNF263_19887448_ChIP-Seq_K562_Human4.22223435
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.04272324
5ESR2_21235772_ChIP-Seq_MCF-7_Human3.47976714
6* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.35840009
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70908675
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.63989810
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61800482
10TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.52016055
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.50661577
12GATA1_22025678_ChIP-Seq_K562_Human2.45348802
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.44230297
14CTCF_20526341_ChIP-Seq_ESCs_Human2.07855381
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.01037640
16TP63_17297297_ChIP-ChIP_HaCaT_Human13.1431954
17RUNX1_27514584_Chip-Seq_MCF-7_Human1.95800055
18E2F1_20622854_ChIP-Seq_HELA_Human1.90389950
19FOXM1_23109430_ChIP-Seq_U2OS_Human1.86415300
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.84861738
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.84861738
22BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.81433749
23* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.77798386
24SCL_19346495_ChIP-Seq_HPC-7_Human1.76965772
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74992865
26SOX9_24532713_ChIP-Seq_HFSC_Mouse1.70073902
27CDX2_20551321_ChIP-Seq_CACO-2_Human1.70053842
28VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.66081646
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.61598649
30BCL6_27268052_Chip-Seq_Bcells_Human1.60873561
31SOX2_20726797_ChIP-Seq_SW620_Human1.60734152
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.59713700
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.58911579
34HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54510773
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.54267425
36EGR1_19032775_ChIP-ChIP_M12_Human1.52679997
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.51603813
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.46729108
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44092078
40ERG_20517297_ChIP-Seq_VCAP_Human1.43509226
41* NANOG_20526341_ChIP-Seq_ESCs_Human1.43348797
42TAF2_19829295_ChIP-Seq_ESCs_Human1.43066736
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.42057766
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.41674932
45PHF8_20622854_ChIP-Seq_HELA_Human1.39680752
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39410928
47P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.38887937
48* ATF3_27146783_Chip-Seq_COLON_Human1.37666657
49AR_21909140_ChIP-Seq_LNCAP_Human1.37530236
50BCOR_27268052_Chip-Seq_Bcells_Human1.35812323
51* CSB_26484114_Chip-Seq_FIBROBLAST_Human1.34210439
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.32638902
53* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.32074392
54TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30654894
55* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29845701
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.29656983
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26778710
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23123927
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21539225
60EGR1_19374776_ChIP-ChIP_THP-1_Human1.21515363
61E2F1_17053090_ChIP-ChIP_MCF-7_Human1.21258289
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20618758
63P68_20966046_ChIP-Seq_HELA_Human1.19197629
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18943519
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16679835
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15165109
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.14354446
68* TP63_22573176_ChIP-Seq_HFKS_Human1.13824931
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13710625
70MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse1.12795588
71GATA1_19941826_ChIP-Seq_K562_Human1.12751034
72* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12600439
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.12400109
74CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12148220
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11517921
76* SMC4_20622854_ChIP-Seq_HELA_Human1.09994994
77CLOCK_20551151_ChIP-Seq_293T_Human1.09869798
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09472464
79ELF5_23300383_ChIP-Seq_T47D_Human1.09168445
80* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08819996
81* GATA1_19941827_ChIP-Seq_MEL_Mouse1.08631588
82GATA4_25053715_ChIP-Seq_YYC3_Human1.08168395
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07259501
84P53_21459846_ChIP-Seq_SAOS-2_Human1.07020201
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05888583
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.05412074
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.04342338
88* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04035286
89* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.03603467
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03057528
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.02481792
92TCF7_22412390_ChIP-Seq_EML_Mouse1.02185057
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02105191
94CEBPB_22108803_ChIP-Seq_LS180_Human1.01427219
95FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01222718
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.00109178
97CHD1_26751641_Chip-Seq_LNCaP_Human1.00082303
98MYC_22102868_ChIP-Seq_BL_Human0.99525145
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98723198
100CREB1_26743006_Chip-Seq_LNCaP_Human0.98437514
101MYC_18555785_ChIP-Seq_MESCs_Mouse0.98417639
102* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98180831
103SPI1_20517297_ChIP-Seq_HL60_Human0.98162107
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97658925
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96750174
106GATA3_24758297_ChIP-Seq_MCF-7_Human0.96648728
107* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96095085
108GATA6_25053715_ChIP-Seq_YYC3_Human0.95645077
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95513316
110RAC3_21632823_ChIP-Seq_H3396_Human0.95454506
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94786569
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94246290
113CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93864969
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93742665
115RUNX_20019798_ChIP-Seq_JUKART_Human0.93024646
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92721613
117VDR_21846776_ChIP-Seq_THP-1_Human0.92658703
118* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92640202
119MYC_19079543_ChIP-ChIP_MESCs_Mouse0.91994677
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.91832619
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.91805856
122ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91667018
123CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91650204
124E2F1_21310950_ChIP-Seq_MCF-7_Human0.90722012
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90402712
126* GATA6_21074721_ChIP-Seq_CACO-2_Human0.89519210
127KDM2B_26808549_Chip-Seq_K562_Human0.89385709
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88043854
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.87609184
130ELK3_25401928_ChIP-Seq_HUVEC_Human0.87573398
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86473335
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.86232688
133KLF5_25053715_ChIP-Seq_YYC3_Human0.85595231
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85487036
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85113922
136E2F4_17652178_ChIP-ChIP_JURKAT_Human0.84664707
137ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84276848
138* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84213870
139EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83297490
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.83241510
141SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.82400589
142SA1_27219007_Chip-Seq_Bcells_Human0.82213453
143MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81671208
144* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81389286
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81194381
146* FOXO3_23340844_ChIP-Seq_DLD1_Human0.80746425
147SA1_27219007_Chip-Seq_ERYTHROID_Human0.79321899
148RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.79307740
149GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.78507038
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.77904773
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.77734788
152TP63_23658742_ChIP-Seq_EP156T_Human0.76609224
153* CTCF_27219007_Chip-Seq_Bcells_Human0.75517893
154STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.75450017
155GATA2_19941826_ChIP-Seq_K562_Human0.75405145
156SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74105758
157AHR_22903824_ChIP-Seq_MCF-7_Human0.73704835
158SOX2_21211035_ChIP-Seq_LN229_Human0.73573310
159LXR_22292898_ChIP-Seq_THP-1_Human0.72338944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology7.26098517
2MP0002098_abnormal_vibrissa_morphology6.67004677
3MP0000647_abnormal_sebaceous_gland5.71140385
4MP0002796_impaired_skin_barrier5.41548952
5MP0000383_abnormal_hair_follicle4.54109281
6MP0005275_abnormal_skin_tensile4.34544757
7MP0010386_abnormal_urinary_bladder3.79655403
8MP0000377_abnormal_hair_follicle3.79360146
9MP0010234_abnormal_vibrissa_follicle3.72454241
10MP0005501_abnormal_skin_physiology3.71463335
11MP0010678_abnormal_skin_adnexa3.71244662
12MP0000427_abnormal_hair_cycle3.41078729
13MP0003705_abnormal_hypodermis_morpholog3.12561425
14MP0002254_reproductive_system_inflammat2.76674568
15MP0001216_abnormal_epidermal_layer2.73146572
16MP0004947_skin_inflammation2.40238283
17MP0004381_abnormal_hair_follicle2.35166622
18MP0003453_abnormal_keratinocyte_physiol2.32128816
19MP0000367_abnormal_coat/_hair2.25749477
20MP0010771_integument_phenotype2.24655730
21MP0002060_abnormal_skin_morphology2.22313848
22MP0001243_abnormal_dermal_layer2.05962278
23MP0009780_abnormal_chondrocyte_physiolo2.03283073
24MP0008875_abnormal_xenobiotic_pharmacok1.98985472
25MP0000534_abnormal_ureter_morphology1.96714230
26MP0003941_abnormal_skin_development1.95533385
27MP0001756_abnormal_urination1.85920891
28MP0000537_abnormal_urethra_morphology1.79679559
29MP0000467_abnormal_esophagus_morphology1.77427340
30MP0005083_abnormal_biliary_tract1.72192741
31MP0009931_abnormal_skin_appearance1.68619552
32MP0003566_abnormal_cell_adhesion1.65542135
33MP0008789_abnormal_olfactory_epithelium1.50870741
34MP0002234_abnormal_pharynx_morphology1.50110532
35MP0009053_abnormal_anal_canal1.43308085
36MP0000762_abnormal_tongue_morphology1.39202579
37MP0001873_stomach_inflammation1.35970613
38MP0002877_abnormal_melanocyte_morpholog1.29112165
39MP0005409_darkened_coat_color1.23526492
40MP0005248_abnormal_Harderian_gland1.22727189
41MP0001191_abnormal_skin_condition1.16505140
42MP0002089_abnormal_postnatal_growth/wei1.12039316
43MP0003191_abnormal_cellular_cholesterol1.11849677
44MP0001348_abnormal_lacrimal_gland1.09831046
45MP0005499_abnormal_olfactory_system1.07115263
46MP0005394_taste/olfaction_phenotype1.07115263
47MP0002095_abnormal_skin_pigmentation1.06864919
48MP0000566_synostosis1.04722551
49MP0004264_abnormal_extraembryonic_tissu1.04290824
50MP0001881_abnormal_mammary_gland0.99260599
51MP0000858_altered_metastatic_potential0.98999870
52MP0003806_abnormal_nucleotide_metabolis0.97306933
53MP0001765_abnormal_ion_homeostasis0.93069881
54MP0006054_spinal_hemorrhage0.88028741
55MP0005670_abnormal_white_adipose0.87970911
56MP0003111_abnormal_nucleus_morphology0.87514753
57MP0003315_abnormal_perineum_morphology0.87265447
58MP0010352_gastrointestinal_tract_polyps0.86445634
59MP0001851_eye_inflammation0.83703313
60MP0001346_abnormal_lacrimal_gland0.81897316
61MP0003763_abnormal_thymus_physiology0.80117109
62MP0010094_abnormal_chromosome_stability0.78156733
63MP0009643_abnormal_urine_homeostasis0.74945216
64MP0008007_abnormal_cellular_replicative0.74584437
65MP0000627_abnormal_mammary_gland0.71947534
66MP0005666_abnormal_adipose_tissue0.70812764
67MP0000613_abnormal_salivary_gland0.70286808
68MP0003656_abnormal_erythrocyte_physiolo0.69640483
69MP0006138_congestive_heart_failure0.68454076
70MP0003638_abnormal_response/metabolism_0.68351634
71MP0001545_abnormal_hematopoietic_system0.64856945
72MP0005397_hematopoietic_system_phenotyp0.64856945
73MP0004885_abnormal_endolymph0.64208549
74MP0010030_abnormal_orbit_morphology0.64168089
75MP0001849_ear_inflammation0.63752628
76MP0005058_abnormal_lysosome_morphology0.63505809
77MP0002136_abnormal_kidney_physiology0.62763587
78MP0001664_abnormal_digestion0.62685249
79MP0008260_abnormal_autophagy0.61887212
80MP0005075_abnormal_melanosome_morpholog0.61728580
81MP0004858_abnormal_nervous_system0.61208045
82MP0005023_abnormal_wound_healing0.60910270
83MP0000470_abnormal_stomach_morphology0.60615750
84MP0003936_abnormal_reproductive_system0.59634315
85MP0004272_abnormal_basement_membrane0.59118665
86MP0000465_gastrointestinal_hemorrhage0.58274248
87MP0003183_abnormal_peptide_metabolism0.58238384
88MP0002009_preneoplasia0.57712772
89MP0001784_abnormal_fluid_regulation0.57637634
90MP0009379_abnormal_foot_pigmentation0.57055188
91MP0003693_abnormal_embryo_hatching0.56175429
92MP0005310_abnormal_salivary_gland0.55661393
93MP0005377_hearing/vestibular/ear_phenot0.55317626
94MP0003878_abnormal_ear_physiology0.55317626
95MP0002970_abnormal_white_adipose0.55235046
96MP0000733_abnormal_muscle_development0.55091293
97MP0004043_abnormal_pH_regulation0.54487464
98MP0004185_abnormal_adipocyte_glucose0.53567884
99MP0001340_abnormal_eyelid_morphology0.53271692
100MP0003786_premature_aging0.52608666
101MP0005451_abnormal_body_composition0.52567566
102MP0001661_extended_life_span0.50354748
103MP0003436_decreased_susceptibility_to0.49413806
104MP0002697_abnormal_eye_size0.49156157
105MP0003755_abnormal_palate_morphology0.49083215
106MP0002132_abnormal_respiratory_system0.48722152
107MP0003115_abnormal_respiratory_system0.48503932
108MP0002111_abnormal_tail_morphology0.48278877
109MP0005076_abnormal_cell_differentiation0.47069605
110MP0004233_abnormal_muscle_weight0.45590644
111MP0002896_abnormal_bone_mineralization0.44723678
112MP0004957_abnormal_blastocyst_morpholog0.43747575
113MP0008877_abnormal_DNA_methylation0.42782409
114MP0001730_embryonic_growth_arrest0.41992081
115MP0010307_abnormal_tumor_latency0.41393100
116MP0004147_increased_porphyrin_level0.40069195
117MP0002249_abnormal_larynx_morphology0.39392436
118MP0000678_abnormal_parathyroid_gland0.38815548
119MP0000490_abnormal_crypts_of0.38516412
120MP0000432_abnormal_head_morphology0.36213788
121MP0002282_abnormal_trachea_morphology0.35183923
122MP0002396_abnormal_hematopoietic_system0.34475099
123MP0004197_abnormal_fetal_growth/weight/0.33851460
124MP0009278_abnormal_bone_marrow0.33560212
125MP0003300_gastrointestinal_ulcer0.32733843
126MP0000350_abnormal_cell_proliferation0.32461101
127MP0002006_tumorigenesis0.32159204
128MP0005464_abnormal_platelet_physiology0.32122749
129MP0003077_abnormal_cell_cycle0.32057287
130MP0001835_abnormal_antigen_presentation0.31602998
131MP0001286_abnormal_eye_development0.31522619
132MP0002722_abnormal_immune_system0.30749389
133MP0002166_altered_tumor_susceptibility0.30183885
134MP0003448_altered_tumor_morphology0.28991125
135MP0002019_abnormal_tumor_incidence0.28731407
136MP0000516_abnormal_urinary_system0.28375078
137MP0005367_renal/urinary_system_phenotyp0.28375078
138MP0003950_abnormal_plasma_membrane0.28004961
139MP0009333_abnormal_splenocyte_physiolog0.27975361
140MP0004782_abnormal_surfactant_physiolog0.27069697
141MP0001800_abnormal_humoral_immune0.26609830
142MP0002086_abnormal_extraembryonic_tissu0.26570854

Predicted human phenotypes

RankGene SetZ-score
1Slow-growing hair (HP:0002217)9.99863028
2Abnormality of hair growth rate (HP:0011363)9.99863028
3Pili torti (HP:0003777)8.98447027
4Brittle hair (HP:0002299)8.42518351
5Nail dystrophy (HP:0008404)6.68162395
6Abnormality of nail color (HP:0100643)6.59372488
7Fragile nails (HP:0001808)5.73516673
8Abnormal hair laboratory examination (HP:0003328)5.62595968
9Onycholysis (HP:0001806)5.50220092
10Alopecia of scalp (HP:0002293)5.15784919
11Palmoplantar hyperkeratosis (HP:0000972)4.75069382
12Thick nail (HP:0001805)4.74793887
13Follicular hyperkeratosis (HP:0007502)4.72382376
14Plantar hyperkeratosis (HP:0007556)4.66515010
15Palmar hyperkeratosis (HP:0010765)4.51345524
16Fine hair (HP:0002213)4.50658471
17Increased IgE level (HP:0003212)4.44816200
18Abnormality of the salivary glands (HP:0010286)4.12860866
19Milia (HP:0001056)3.96244135
20Sparse eyelashes (HP:0000653)3.89014596
21Pterygium (HP:0001059)3.81575145
22Focal segmental glomerulosclerosis (HP:0000097)3.67303005
23Oral leukoplakia (HP:0002745)3.63848374
24Right ventricular cardiomyopathy (HP:0011663)3.62724848
25Hyperactive renin-angiotensin system (HP:0000841)3.47668259
26Glomerulosclerosis (HP:0000096)3.40444752
27Erythema (HP:0010783)3.39232276
28Amelogenesis imperfecta (HP:0000705)3.37878083
29Fragile skin (HP:0001030)3.32005731
30Aplasia cutis congenita (HP:0001057)3.19888086
31Hypoplasia of dental enamel (HP:0006297)3.09111864
32Abnormality of the frontal sinuses (HP:0002687)3.01931487
33Parakeratosis (HP:0001036)2.94365385
34Septate vagina (HP:0001153)2.93848291
35Congenital, generalized hypertrichosis (HP:0004540)2.90486945
36Abnormal blistering of the skin (HP:0008066)2.80036051
37Curly hair (HP:0002212)2.78484361
38Abnormality of the distal phalanges of the toes (HP:0010182)2.71381257
39Polygenic inheritance (HP:0010982)2.68714103
40Hyperacusis (HP:0010780)2.67015265
41Nasolacrimal duct obstruction (HP:0000579)2.66864125
42Erythroderma (HP:0001019)2.65344554
43Breast hypoplasia (HP:0003187)2.62820073
44Osteolytic defects of the hand bones (HP:0009699)2.61363085
45Osteolytic defects of the phalanges of the hand (HP:0009771)2.61363085
46Broad face (HP:0000283)2.60338136
47Growth hormone excess (HP:0000845)2.59943261
48Trismus (HP:0000211)2.59307321
49Ankyloglossia (HP:0010296)2.59090850
50Chronic bronchitis (HP:0004469)2.51568072
51Acanthosis nigricans (HP:0000956)2.49376801
52Ridged nail (HP:0001807)2.46979971
53Seborrheic dermatitis (HP:0001051)2.46711997
54Blepharitis (HP:0000498)2.46636857
55Sparse lateral eyebrow (HP:0005338)2.44797561
56Dry hair (HP:0011359)2.44226478
57Natal tooth (HP:0000695)2.44079190
58Oligodontia (HP:0000677)2.43393452
59Hypoplastic labia majora (HP:0000059)2.40456514
60Popliteal pterygium (HP:0009756)2.36520211
61Renal salt wasting (HP:0000127)2.36260965
62Abnormality of dental color (HP:0011073)2.31028292
63Advanced eruption of teeth (HP:0006288)2.19735119
64Abnormality of the parietal bone (HP:0002696)2.15240470
65Hypohidrosis (HP:0000966)2.14145728
66Multifactorial inheritance (HP:0001426)2.13925650
67Lip pit (HP:0100267)2.13710201
68Abnormality of the axillary hair (HP:0100134)2.12943774
69Abnormality of secondary sexual hair (HP:0009888)2.12943774
70Abnormality of the labia majora (HP:0012881)2.12542034
71Neonatal death (HP:0003811)2.12521079
72Partial duplication of thumb phalanx (HP:0009944)2.12411013
73Abnormality of oral frenula (HP:0000190)2.12004226
74Congenital ichthyosiform erythroderma (HP:0007431)2.11877833
75Flat acetabular roof (HP:0003180)2.09814581
76Hemorrhage of the eye (HP:0011885)2.07523826
77Corneal erosion (HP:0200020)2.05099124
78Hyperuricemia (HP:0002149)2.04671485
79Increased purine levels (HP:0004368)2.04671485
80Bilateral sensorineural hearing impairment (HP:0008619)2.01179380
81Hypotrichosis (HP:0001006)12.6024155
82Woolly hair (HP:0002224)10.2626029
83Eczematoid dermatitis (HP:0000976)1.99504385
84Ectropion (HP:0000656)1.99023899
85Anonychia (HP:0001798)1.98241588
86Keratoconjunctivitis sicca (HP:0001097)1.97738485
87Hyperkalemia (HP:0002153)1.97401145
88Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.97314218
89Abnormality of the lacrimal duct (HP:0011481)1.95510963
90Short middle phalanx of the 5th finger (HP:0004220)1.95195596
91Dehydration (HP:0001944)1.94334206
92Distal lower limb amyotrophy (HP:0008944)1.93797188
93Petechiae (HP:0000967)1.93727773
94Aplasia involving bones of the extremities (HP:0009825)1.92229179
95Aplasia involving bones of the upper limbs (HP:0009823)1.92229179
96Aplasia of the phalanges of the hand (HP:0009802)1.92229179
97Pruritus (HP:0000989)1.91827618
98Abnormality of permanent molar morphology (HP:0011071)1.91795802
99Abnormality of the dental root (HP:0006486)1.91795802
100Taurodontia (HP:0000679)1.91795802
101Conical tooth (HP:0000698)1.90891642
102Abnormality of molar morphology (HP:0011070)1.89342393
103Abnormality of molar (HP:0011077)1.89342393
104Cerebral palsy (HP:0100021)1.88962641
105Absent eyelashes (HP:0000561)1.88531085
106Ureteral stenosis (HP:0000071)1.88210273
107Neck muscle weakness (HP:0000467)1.85834166
108Palmoplantar keratoderma (HP:0000982)1.84553014
109Esophageal atresia (HP:0002032)1.83606663
110Premature loss of primary teeth (HP:0006323)1.83464985
111Fatigable weakness (HP:0003473)1.81327578
112Abnormality of the neuromuscular junction (HP:0003398)1.81327578
113Anhidrosis (HP:0000970)1.80809038
114Keratoconjunctivitis (HP:0001096)1.77877691
115Thin bony cortex (HP:0002753)1.77090621
116Tongue fasciculations (HP:0001308)1.76791244
117Sparse scalp hair (HP:0002209)1.73361000
118Xerostomia (HP:0000217)1.71711922
119Germ cell neoplasia (HP:0100728)1.70433820
120Recurrent corneal erosions (HP:0000495)1.70254811
121Partial duplication of the phalanx of hand (HP:0009999)1.69944821
122Unilateral renal agenesis (HP:0000122)1.69905488
123Carious teeth (HP:0000670)1.66490432
124Selective tooth agenesis (HP:0001592)1.64483095
125Distal lower limb muscle weakness (HP:0009053)1.62419515
126Abnormality of the dental pulp (HP:0006479)1.59937548
127Atrophic scars (HP:0001075)1.56452469
128Abnormality of the aortic arch (HP:0012303)1.52033126
129Abnormality of the pupil (HP:0000615)1.50992684
130Tetraparesis (HP:0002273)1.50969102
131Intention tremor (HP:0002080)1.49865736
132Recurrent bacterial skin infections (HP:0005406)1.47373821
133Abnormality of the fingernails (HP:0001231)1.46541019
134Poikilocytosis (HP:0004447)1.46447733
135Ventricular tachycardia (HP:0004756)1.43879331
136Skin ulcer (HP:0200042)1.41966062
137Severe Myopia (HP:0011003)1.34759023
138Hypergammaglobulinemia (HP:0010702)1.33581852
139Abnormality of the gastric mucosa (HP:0004295)1.32832257
140Gangrene (HP:0100758)1.32407622
141Difficulty walking (HP:0002355)1.31129263
142Widely spaced teeth (HP:0000687)1.30510745
143Craniofacial hyperostosis (HP:0004493)1.29704224
144Duplicated collecting system (HP:0000081)1.28546415
145Torticollis (HP:0000473)1.27374355
146Furrowed tongue (HP:0000221)1.26716921
147Squamous cell carcinoma (HP:0002860)1.25437100
148Laryngomalacia (HP:0001601)1.23583472
149Urticaria (HP:0001025)1.20876538
150Widely patent fontanelles and sutures (HP:0004492)1.20657743
151Amniotic constriction ring (HP:0009775)1.18543501
152Abnormality of placental membranes (HP:0011409)1.18543501
153Abnormality of the nasal septum (HP:0000419)1.14476378
154Heterogeneous (HP:0001425)1.13809540
155Ectopic kidney (HP:0000086)1.11845843
156Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.10924744
157Short 4th metacarpal (HP:0010044)1.10924744
158Abnormality of the preputium (HP:0100587)1.10128687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R8.11839971
2MET4.00757455
3EPHA23.55217913
4MAP3K33.18670860
5MAP3K62.96768597
6IRAK32.94210639
7SIK12.84736211
8NME22.58393769
9EEF2K2.48940939
10PIM22.42401002
11PRPF4B2.41751043
12RPS6KB22.40202104
13LATS12.24371929
14EIF2AK12.17176676
15FER2.11199273
16MAPKAPK32.05554626
17SMG12.00856782
18TRPM71.83815754
19ERN11.83458788
20TAOK11.75245601
21MAP3K101.73447994
22MKNK21.64657931
23CDK61.64566708
24STK31.61181320
25PIM11.58810659
26TYK21.57435370
27EPHB21.57386639
28RPS6KA41.56083890
29CLK11.55807815
30STK241.50377652
31BMX1.46752562
32RIPK11.43003005
33STK41.42702620
34MST41.39976524
35MAP2K31.36668141
36STK38L1.34303640
37RPS6KA61.32047090
38RPS6KL11.31683619
39RPS6KC11.31683619
40TAOK31.31647504
41ACVR1B1.30476267
42MAP2K61.29395992
43TAOK21.29124932
44SGK31.25267970
45CDK81.24761936
46TNK21.23829539
47GRK51.22272093
48TESK11.21739996
49MAP3K21.21411562
50SGK21.20972090
51MKNK11.17173916
52MAP3K111.16209423
53AKT31.14839230
54CDK121.13060440
55MAPKAPK21.10153760
56MAP4K11.08492038
57PBK1.03642405
58TRIB31.01593731
59MAP3K131.00088825
60PAK40.99982188
61EPHB10.99306855
62MAP3K90.96823303
63CHUK0.95925296
64RPS6KA20.95565535
65DYRK1B0.95206121
66NTRK10.93519683
67PDGFRA0.93057168
68ERBB30.91774521
69ZAK0.89908382
70RPS6KA10.89161960
71STK100.87689074
72DDR20.86996241
73MAP3K140.86181531
74IKBKE0.85020638
75CDC70.84330749
76ICK0.83857780
77IRAK40.83647644
78MAP3K120.80366144
79CDK90.80080043
80NME10.79602100
81FGFR30.77861385
82ATR0.77370134
83MUSK0.76961222
84BRD40.76253829
85TESK20.75908745
86TSSK60.75793123
87IKBKB0.74428448
88BLK0.73816663
89FGFR10.73204270
90VRK20.71335030
91PIK3CG0.71134627
92LMTK20.71031708
93ALK0.70107603
94BCR0.69884429
95BRSK20.69367205
96SIK30.68566577
97TXK0.67555030
98PKN20.66897287
99CDK30.66314910
100TGFBR10.65120699
101BTK0.65106252
102MATK0.64184782
103ILK0.63791222
104CHEK10.63242408
105PRKCI0.62767770
106LATS20.62401517
107CDK40.61708634
108AURKB0.58998235
109FLT30.57760834
110LRRK20.57407927
111ARAF0.56718236
112JAK30.56564122
113MAP3K80.54831348
114JAK20.52217349
115MAPK110.52128153
116BMPR1B0.52090714
117ATM0.51249049
118PTK60.50537822
119PASK0.49031250
120CSNK1D0.48816953
121CDK70.48675371
122MTOR0.48048883
123MAP3K50.47430832
124PRKD20.47233829
125ERBB40.46424520
126HCK0.45922026
127NEK60.45129056
128SRPK10.44702419
129NEK10.44470331
130DAPK10.43433977
131YES10.43233847
132RPS6KB10.42062211
133SYK0.41505115
134JAK10.40744508
135AKT10.40616027
136PTK20.40336532
137MAP3K70.39931637
138FGR0.39679111
139MAP2K10.39625584
140MAPK80.39119850
141MAPK140.37372390
142MELK0.37300984
143IRAK20.37244010
144STK380.36764315
145CDC42BPA0.35579216
146HIPK20.33804089
147SCYL20.33708406
148ZAP700.31494320
149PDGFRB0.31285688
150CSF1R0.31123861
151MAPKAPK50.29641563
152BRSK10.28188517
153TBK10.27550283
154NEK20.27238609
155FGFR40.24531800
156PRKG20.23984554
157LIMK10.23733255
158MAP2K20.22958246
159EIF2AK20.22568796
160PRKD30.20248288
161ERBB20.20079162

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.26596892
2Glutathione metabolism_Homo sapiens_hsa004803.20904296
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.20901172
4Linoleic acid metabolism_Homo sapiens_hsa005913.07545422
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.35874746
6Basal cell carcinoma_Homo sapiens_hsa052172.31181712
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.13339417
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06863582
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01195124
10Chemical carcinogenesis_Homo sapiens_hsa052041.90636901
11DNA replication_Homo sapiens_hsa030301.89700734
12p53 signaling pathway_Homo sapiens_hsa041151.87683438
13Fructose and mannose metabolism_Homo sapiens_hsa000511.87154975
14Pentose phosphate pathway_Homo sapiens_hsa000301.86073320
15Acute myeloid leukemia_Homo sapiens_hsa052211.85456969
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.83452347
17Galactose metabolism_Homo sapiens_hsa000521.82549636
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.77389037
19Arachidonic acid metabolism_Homo sapiens_hsa005901.71870916
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.68674010
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.61222103
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60718405
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.60490533
24Ether lipid metabolism_Homo sapiens_hsa005651.55402822
25Apoptosis_Homo sapiens_hsa042101.52646112
26Base excision repair_Homo sapiens_hsa034101.50537932
27Cell cycle_Homo sapiens_hsa041101.50007833
28Leishmaniasis_Homo sapiens_hsa051401.48563734
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44429549
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43984159
31Toxoplasmosis_Homo sapiens_hsa051451.37941052
32Herpes simplex infection_Homo sapiens_hsa051681.36675737
33Hippo signaling pathway_Homo sapiens_hsa043901.34509237
34Starch and sucrose metabolism_Homo sapiens_hsa005001.34308147
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33361816
36Bladder cancer_Homo sapiens_hsa052191.32670175
37Hedgehog signaling pathway_Homo sapiens_hsa043401.31667447
38MicroRNAs in cancer_Homo sapiens_hsa052061.28214424
39Chronic myeloid leukemia_Homo sapiens_hsa052201.27872907
40Endometrial cancer_Homo sapiens_hsa052131.27663473
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27299087
42Spliceosome_Homo sapiens_hsa030401.25520826
43Other glycan degradation_Homo sapiens_hsa005111.25064976
44One carbon pool by folate_Homo sapiens_hsa006701.24886556
45HTLV-I infection_Homo sapiens_hsa051661.24882387
46N-Glycan biosynthesis_Homo sapiens_hsa005101.22891560
47Mismatch repair_Homo sapiens_hsa034301.22849927
48Non-small cell lung cancer_Homo sapiens_hsa052231.22505592
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19546204
50Proteoglycans in cancer_Homo sapiens_hsa052051.18372694
51RNA transport_Homo sapiens_hsa030131.17342610
52Measles_Homo sapiens_hsa051621.16816421
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.15791236
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12456188
55Thyroid cancer_Homo sapiens_hsa052161.12005934
56Legionellosis_Homo sapiens_hsa051341.10509872
57Notch signaling pathway_Homo sapiens_hsa043301.09754288
58Biosynthesis of amino acids_Homo sapiens_hsa012301.09544051
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05904071
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04678536
61Influenza A_Homo sapiens_hsa051641.04492808
62Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03867227
63Adherens junction_Homo sapiens_hsa045201.01425005
64Tuberculosis_Homo sapiens_hsa051521.00887243
65mRNA surveillance pathway_Homo sapiens_hsa030151.00174194
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00163639
67Pertussis_Homo sapiens_hsa051330.99384196
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.97568810
69Hepatitis C_Homo sapiens_hsa051600.95966331
70Fat digestion and absorption_Homo sapiens_hsa049750.95846942
71Histidine metabolism_Homo sapiens_hsa003400.95374470
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94968297
73Tyrosine metabolism_Homo sapiens_hsa003500.92818810
74Hepatitis B_Homo sapiens_hsa051610.92231123
75ECM-receptor interaction_Homo sapiens_hsa045120.90590051
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.90244810
77Endocytosis_Homo sapiens_hsa041440.88093297
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.87982407
79Antigen processing and presentation_Homo sapiens_hsa046120.87740825
80Wnt signaling pathway_Homo sapiens_hsa043100.86234827
81VEGF signaling pathway_Homo sapiens_hsa043700.85077857
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.82412760
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82392413
84Inositol phosphate metabolism_Homo sapiens_hsa005620.82291253
85Focal adhesion_Homo sapiens_hsa045100.82216396
86Melanoma_Homo sapiens_hsa052180.81362843
87Small cell lung cancer_Homo sapiens_hsa052220.81109300
88Viral carcinogenesis_Homo sapiens_hsa052030.80754682
89Pancreatic cancer_Homo sapiens_hsa052120.80420336
90TGF-beta signaling pathway_Homo sapiens_hsa043500.80148119
91Epstein-Barr virus infection_Homo sapiens_hsa051690.79842499
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79333207
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78918860
94Glioma_Homo sapiens_hsa052140.78481012
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76466066
96Hematopoietic cell lineage_Homo sapiens_hsa046400.75664814
97Non-homologous end-joining_Homo sapiens_hsa034500.75559199
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.75238288
99Fanconi anemia pathway_Homo sapiens_hsa034600.74932430
100Platelet activation_Homo sapiens_hsa046110.73701100
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.73308278
102TNF signaling pathway_Homo sapiens_hsa046680.72794444
103Amoebiasis_Homo sapiens_hsa051460.72756920
104Prostate cancer_Homo sapiens_hsa052150.71027711
105Shigellosis_Homo sapiens_hsa051310.70869257
106Mineral absorption_Homo sapiens_hsa049780.70761870
107FoxO signaling pathway_Homo sapiens_hsa040680.70741574
108Allograft rejection_Homo sapiens_hsa053300.70740185
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70515876
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69106067
111Nucleotide excision repair_Homo sapiens_hsa034200.69070067
112Melanogenesis_Homo sapiens_hsa049160.69056393
113Pathways in cancer_Homo sapiens_hsa052000.68774041
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67594038
115Fatty acid elongation_Homo sapiens_hsa000620.67512175
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67309010
117RNA degradation_Homo sapiens_hsa030180.66814728
118Insulin signaling pathway_Homo sapiens_hsa049100.66810023
119ErbB signaling pathway_Homo sapiens_hsa040120.66214418
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66109735
121Sphingolipid metabolism_Homo sapiens_hsa006000.65996284
122Retinol metabolism_Homo sapiens_hsa008300.65930521
123Asthma_Homo sapiens_hsa053100.65837374
124Homologous recombination_Homo sapiens_hsa034400.65156883
125Salmonella infection_Homo sapiens_hsa051320.65118664
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64526247
127Basal transcription factors_Homo sapiens_hsa030220.64513657
128Axon guidance_Homo sapiens_hsa043600.62964821
129Colorectal cancer_Homo sapiens_hsa052100.62709555
130Osteoclast differentiation_Homo sapiens_hsa043800.62413672
131Carbon metabolism_Homo sapiens_hsa012000.59311860
132Pancreatic secretion_Homo sapiens_hsa049720.58805237
133Prolactin signaling pathway_Homo sapiens_hsa049170.58661784
134ABC transporters_Homo sapiens_hsa020100.58060578
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57366602
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56636707
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.56377723
138Dorso-ventral axis formation_Homo sapiens_hsa043200.56291789
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53485350
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53148288
141B cell receptor signaling pathway_Homo sapiens_hsa046620.52094688
142Phenylalanine metabolism_Homo sapiens_hsa003600.52080931
143Glycosaminoglycan degradation_Homo sapiens_hsa005310.52008876
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50880209
145Proteasome_Homo sapiens_hsa030500.50835750
146Tight junction_Homo sapiens_hsa045300.50180019
147Fatty acid biosynthesis_Homo sapiens_hsa000610.48010410
148Lysosome_Homo sapiens_hsa041420.42358667
149Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42038188
150Ovarian steroidogenesis_Homo sapiens_hsa049130.40860799
151Dilated cardiomyopathy_Homo sapiens_hsa054140.40165255
152Renal cell carcinoma_Homo sapiens_hsa052110.39657726
153Sulfur relay system_Homo sapiens_hsa041220.33697075
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32744903
155mTOR signaling pathway_Homo sapiens_hsa041500.32577961
156Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.31741192
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31462683
158Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31263604
159Vibrio cholerae infection_Homo sapiens_hsa051100.30557188
160Arginine biosynthesis_Homo sapiens_hsa002200.29727118

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