PADI6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)8.89938200
2regulation of hypersensitivity (GO:0002883)7.86605670
3DNA methylation involved in gamete generation (GO:0043046)7.57586385
4base-excision repair, AP site formation (GO:0006285)7.20515924
5reproduction (GO:0000003)6.80438113
6oocyte development (GO:0048599)6.79318413
7pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.73527616
8negative regulation of reproductive process (GO:2000242)6.50131018
9positive regulation of humoral immune response (GO:0002922)6.27008114
10regulation of histone H3-K9 methylation (GO:0051570)6.22443870
11mitotic chromosome condensation (GO:0007076)6.16361291
12histone H2A monoubiquitination (GO:0035518)6.14885754
13histone H2A ubiquitination (GO:0033522)6.14823647
14regulation of exit from mitosis (GO:0007096)6.13586893
15regulation of phospholipid biosynthetic process (GO:0071071)6.09894021
16female gamete generation (GO:0007292)6.06894400
17positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.99302805
18protein K6-linked ubiquitination (GO:0085020)5.80510252
19positive regulation of histone H3-K4 methylation (GO:0051571)5.79125344
20mitotic metaphase plate congression (GO:0007080)5.75903530
21pyrimidine nucleotide catabolic process (GO:0006244)5.63456795
22regulation of meiosis (GO:0040020)5.57644893
23positive regulation of reproductive process (GO:2000243)5.55006732
24protein kinase C signaling (GO:0070528)5.48448455
25regulation of steroid hormone secretion (GO:2000831)5.41216315
26protein localization to kinetochore (GO:0034501)5.24009228
27regulation of acute inflammatory response to antigenic stimulus (GO:0002864)5.21396734
28binding of sperm to zona pellucida (GO:0007339)5.16468110
29fertilization (GO:0009566)5.08237932
30negative regulation of smooth muscle cell differentiation (GO:0051151)4.93852213
31oocyte maturation (GO:0001556)4.91695134
32single fertilization (GO:0007338)4.81966727
33immunoglobulin mediated immune response (GO:0016064)4.81194497
34negative regulation of meiosis (GO:0045835)4.76877967
35metaphase plate congression (GO:0051310)4.70628420
36notochord development (GO:0030903)4.67981500
37retinal cone cell development (GO:0046549)4.62790904
38gene silencing by RNA (GO:0031047)4.62701901
39male meiosis (GO:0007140)4.60060583
40meiotic cell cycle (GO:0051321)4.57446974
41protein localization to chromosome, centromeric region (GO:0071459)4.54925998
42negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.53211472
43ovulation cycle (GO:0042698)4.49705824
44regulation of sister chromatid cohesion (GO:0007063)4.44595928
45DNA alkylation (GO:0006305)4.39698680
46DNA methylation (GO:0006306)4.39698680
47regulation of meiotic cell cycle (GO:0051445)4.37273984
48microtubule severing (GO:0051013)4.37084115
49positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.36163760
50establishment of chromosome localization (GO:0051303)4.35421720
51mitotic sister chromatid segregation (GO:0000070)4.26206822
52histone H3-K9 demethylation (GO:0033169)4.21238130
53regulation of calcium ion-dependent exocytosis (GO:0017158)4.16810557
54attachment of spindle microtubules to kinetochore (GO:0008608)4.10955046
55pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.95757253
56sperm-egg recognition (GO:0035036)3.94930952
57chaperone-mediated protein transport (GO:0072321)3.89994674
58phosphatidylinositol dephosphorylation (GO:0046856)3.88630171
59interkinetic nuclear migration (GO:0022027)3.87199778
60positive regulation of meiosis (GO:0045836)3.85078750
61regulation of reproductive process (GO:2000241)3.82293089
62oogenesis (GO:0048477)3.79263775
63histone H3-K4 trimethylation (GO:0080182)3.79243001
64endothelium development (GO:0003158)3.78653701
65N-terminal protein amino acid acetylation (GO:0006474)3.78246356
66regulation of histone H3-K4 methylation (GO:0051569)3.73234665
67protein localization to chromosome (GO:0034502)3.70923478
68histone lysine demethylation (GO:0070076)3.70802113
69regulation of DNA methylation (GO:0044030)3.67334930
70positive regulation of histone methylation (GO:0031062)3.66871189
71regulation of steroid hormone biosynthetic process (GO:0090030)3.66370302
72positive regulation of meiotic cell cycle (GO:0051446)3.65032933
73regulation of chromatin binding (GO:0035561)3.64739325
74regulation of chromatin silencing (GO:0031935)3.64209711
75phospholipid dephosphorylation (GO:0046839)3.61286626
76negative regulation of DNA-templated transcription, elongation (GO:0032785)3.59299943
77negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.59299943
78regulation of cell maturation (GO:1903429)3.55886491
79negative regulation of meiotic cell cycle (GO:0051447)3.54153165
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52588983
81histone demethylation (GO:0016577)3.51809854
82negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.50952998
83positive regulation of gastrulation (GO:2000543)3.49957538
84spindle checkpoint (GO:0031577)3.48924639
85B cell mediated immunity (GO:0019724)3.48452617
86regulation of retinoic acid receptor signaling pathway (GO:0048385)3.47803996
87DNA modification (GO:0006304)3.46944637
88regulation of spindle organization (GO:0090224)3.45616637
89positive regulation of chromosome segregation (GO:0051984)3.44313595
90sister chromatid segregation (GO:0000819)3.42650661
91DNA damage induced protein phosphorylation (GO:0006975)3.41948210
92cell-cell recognition (GO:0009988)3.41533826
93histone H3-K4 methylation (GO:0051568)3.39586535
94negative regulation of histone modification (GO:0031057)3.38320967
95glycine transport (GO:0015816)3.38061213
96negative regulation of histone methylation (GO:0031061)3.34119432
97stress granule assembly (GO:0034063)3.32140670
98regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.32044829
99primitive streak formation (GO:0090009)3.31768172
100cartilage morphogenesis (GO:0060536)3.31000430
101regulation of interleukin-4 production (GO:0032673)3.30691524
102regulation of chromosome segregation (GO:0051983)3.29904617
103positive regulation of interleukin-4 production (GO:0032753)3.27198998
104chromosome segregation (GO:0007059)3.26529222
105phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.26365399
106ribosome assembly (GO:0042255)3.24765360
107protein deneddylation (GO:0000338)3.23269029
108mitotic sister chromatid cohesion (GO:0007064)3.21245223
109regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.19560076
110protein dealkylation (GO:0008214)3.19480401
111protein demethylation (GO:0006482)3.19480401
112DNA methylation or demethylation (GO:0044728)3.19046555
113negative regulation of chromosome segregation (GO:0051985)3.18791065
114positive regulation of calcium ion import (GO:0090280)3.18681358
115type B pancreatic cell development (GO:0003323)3.17874296
116phosphatidylglycerol biosynthetic process (GO:0006655)3.14805518
117negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.14479862
118negative regulation of sister chromatid segregation (GO:0033046)3.14479862
119negative regulation of mitotic sister chromatid separation (GO:2000816)3.14479862
120negative regulation of mitotic sister chromatid segregation (GO:0033048)3.14479862
121gene silencing (GO:0016458)3.14192305
122histone monoubiquitination (GO:0010390)3.14145402
123regulation of histone methylation (GO:0031060)3.12251439
124synaptonemal complex assembly (GO:0007130)3.12203990
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11015082
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11015082
127positive regulation of mitotic sister chromatid separation (GO:1901970)3.11015082
128regulation of meiosis I (GO:0060631)3.09771146
129positive regulation of hormone biosynthetic process (GO:0046886)3.08234573
130histone H3-K36 demethylation (GO:0070544)3.07689649
131regulation of mitotic spindle organization (GO:0060236)3.07169238
132regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.05706831
133mitotic spindle assembly checkpoint (GO:0007094)3.05429069
134negative regulation of chromatin modification (GO:1903309)3.00151781
135positive regulation of gene expression, epigenetic (GO:0045815)3.00081086
136positive regulation of exocytosis (GO:0045921)2.98362429
137positive regulation of DNA-dependent DNA replication (GO:2000105)2.89622750
138negative regulation of organelle assembly (GO:1902116)2.86606249
139regulation of inflammatory response to antigenic stimulus (GO:0002861)2.83794243
140regulation of cell cycle G2/M phase transition (GO:1902749)2.82652591
141DNA replication checkpoint (GO:0000076)2.76565816
142regulation of corticosteroid hormone secretion (GO:2000846)2.76308701
143synaptonemal complex organization (GO:0070193)2.75639480
144phosphorelay signal transduction system (GO:0000160)2.73446500
145positive regulation of endothelial cell differentiation (GO:0045603)2.73249836
146negative regulation of gene silencing (GO:0060969)2.71526853
147negative regulation of hormone biosynthetic process (GO:0032353)2.64962803
148regulation of gene expression by genetic imprinting (GO:0006349)2.62968659
149male meiosis I (GO:0007141)2.62967263
150positive regulation of steroid hormone secretion (GO:2000833)2.60619214
151regulation of female gonad development (GO:2000194)14.7264035
152piRNA metabolic process (GO:0034587)11.4463205
153regulation of acrosome reaction (GO:0060046)11.0771418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.98596681
2EZH2_22144423_ChIP-Seq_EOC_Human4.91727097
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.66911439
4E2F7_22180533_ChIP-Seq_HELA_Human4.26188100
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.22439770
6AR_21909140_ChIP-Seq_LNCAP_Human3.88619341
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.67423006
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.45191444
9KAP1_22055183_ChIP-Seq_ESCs_Mouse3.24575398
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.21020416
11MYC_18940864_ChIP-ChIP_HL60_Human2.30560216
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26271116
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.12960635
14NOTCH1_21737748_ChIP-Seq_TLL_Human1.99746024
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91764424
16MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.88923450
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78625125
18GATA1_26923725_Chip-Seq_HPCs_Mouse1.74902592
19RNF2_27304074_Chip-Seq_NSC_Mouse1.72477794
20GATA3_21867929_ChIP-Seq_TH1_Mouse1.70180397
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68845475
22SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63995790
23NANOG_21062744_ChIP-ChIP_HESCs_Human1.60737609
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57923307
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.56857480
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44495035
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41791281
28KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41791281
29KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41791281
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39607057
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38572954
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35873918
33GABP_19822575_ChIP-Seq_HepG2_Human1.30132189
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27440259
35STAT1_17558387_ChIP-Seq_HELA_Human1.25686320
36* ESET_19884257_ChIP-Seq_ESCs_Mouse1.25035570
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24246313
38STAT1_20625510_ChIP-Seq_HELA_Human1.23968401
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.22795877
40* E2F1_21310950_ChIP-Seq_MCF-7_Human1.22081356
41RUNX1_26923725_Chip-Seq_HPCs_Mouse1.21175380
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19865340
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19764680
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.16930716
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16222494
46IGF1R_20145208_ChIP-Seq_DFB_Human1.15722334
47* NFYA_21822215_ChIP-Seq_K562_Human1.15091632
48E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15090533
49* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13737617
50GBX2_23144817_ChIP-Seq_PC3_Human1.13432629
51* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.13256761
52SPI1_26923725_Chip-Seq_HPCs_Mouse1.12931074
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12880483
54NANOG_20526341_ChIP-Seq_ESCs_Human1.12141392
55* CDX2_22108803_ChIP-Seq_LS180_Human1.09957969
56HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09611267
57* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08983949
58TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07728161
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07394410
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07394410
61SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06727032
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05124102
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.04853423
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04469907
65* ETV1_20927104_ChIP-Seq_GIST48_Human1.04291063
66GATA3_26560356_Chip-Seq_TH1_Human1.03524712
67NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03179040
68CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02951859
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.02306658
70* RBPJ_21746931_ChIP-Seq_IB4_Human1.01881008
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01257545
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00662184
73TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99416129
74* HNFA_21074721_ChIP-Seq_CACO-2_Human0.98978061
75LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98866463
76GF1_26923725_Chip-Seq_HPCs_Mouse0.97795826
77SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96617913
78* OCT4_19829295_ChIP-Seq_ESCs_Human0.95563027
79TCF4_23295773_ChIP-Seq_U87_Human0.94980652
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94554279
81FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94525154
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94073375
83NFE2_27457419_Chip-Seq_LIVER_Mouse0.92973637
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.92776680
85* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92415548
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92033715
87EZH2_27294783_Chip-Seq_NPCs_Mouse0.91399080
88TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.91203561
89CTCF_18555785_Chip-Seq_ESCs_Mouse0.90708542
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90685417
91FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89849663
92LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89776062
93* GATA6_21074721_ChIP-Seq_CACO-2_Human0.89445702
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.89270205
95GF1B_26923725_Chip-Seq_HPCs_Mouse0.89186135
96DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86975829
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.85671293
98MYC_27129775_Chip-Seq_CORNEA_Mouse0.85468710
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85190461
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84683538
101ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84567662
102STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84490197
103* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82901664
104* PHF8_20622853_ChIP-Seq_HELA_Human0.82722413
105TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82567558
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82375332
107KLF4_19829295_ChIP-Seq_ESCs_Human0.82341781
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.82273952
109ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82192748
110MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.81975802
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81815049
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.81709631
113ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.81015569
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80972434
115* OCT4_20526341_ChIP-Seq_ESCs_Human0.80967648
116ERG_20517297_ChIP-Seq_VCAP_Human0.80629273
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79893057
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79875094
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79764195
120AR_25329375_ChIP-Seq_VCAP_Human0.79653682
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.79561383
122RXR_22108803_ChIP-Seq_LS180_Human0.79451355
123ESRRB_18555785_Chip-Seq_ESCs_Mouse0.79308326
124TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.78052527
125KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77565269
126* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.77363234
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.77310715
128ZFX_18555785_Chip-Seq_ESCs_Mouse0.76912664
129STAT3_23295773_ChIP-Seq_U87_Human0.76889318
130BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.76610184
131RUNX2_22187159_ChIP-Seq_PCA_Human0.75908150
132ESR1_20079471_ChIP-ChIP_T-47D_Human0.73332077
133SMAD4_21799915_ChIP-Seq_A2780_Human0.73109350
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72497169
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.71538694
136SMRT_27268052_Chip-Seq_Bcells_Human0.67597436
137CBP_21632823_ChIP-Seq_H3396_Human0.67509045
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.67429364
139KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.66661640
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.66306867
141P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.65426815
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62804082
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.62468754
144EZH2_27304074_Chip-Seq_ESCs_Mouse0.62059062
145SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.61941583
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.61625846
147CBP_20019798_ChIP-Seq_JUKART_Human0.61625846
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.58922580
149DROSHA_22980978_ChIP-Seq_HELA_Human0.56919871
150E2F1_17053090_ChIP-ChIP_MCF-7_Human0.56399566
151ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.56340548
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.55225871
153SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.53718353
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.53611129
155PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.52900997
156SMAD4_21741376_ChIP-Seq_ESCs_Human0.51474371
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.51248510
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.50291912
159REST_21632747_ChIP-Seq_MESCs_Mouse0.49386165
160SMC1_22415368_ChIP-Seq_MEFs_Mouse0.48912135
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.47686663
162* SOX2_21211035_ChIP-Seq_LN229_Gbm0.47386010
163* AR_19668381_ChIP-Seq_PC3_Human0.47118587
164BMI1_23680149_ChIP-Seq_NPCS_Mouse0.46752886
165SMAD4_21741376_ChIP-Seq_HESCs_Human0.46504176
166GATA3_21878914_ChIP-Seq_MCF-7_Human0.46310352
167BP1_19119308_ChIP-ChIP_Hs578T_Human0.46029958
168NCOR_22424771_ChIP-Seq_293T_Human0.45764102
169STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.45462003
170FOXO3_23340844_ChIP-Seq_DLD1_Human0.45352499
171BCOR_27268052_Chip-Seq_Bcells_Human0.45294494
172NR3C1_23031785_ChIP-Seq_PC12_Mouse0.44756183

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect8.81897010
2MP0003646_muscle_fatigue6.37128917
3MP0008877_abnormal_DNA_methylation4.84293640
4MP0005395_other_phenotype3.73118011
5MP0003693_abnormal_embryo_hatching3.72214213
6* MP0003699_abnormal_female_reproductive3.33784447
7MP0008789_abnormal_olfactory_epithelium3.28942215
8MP0010094_abnormal_chromosome_stability3.26574707
9MP0001119_abnormal_female_reproductive3.22981191
10MP0005451_abnormal_body_composition3.12575652
11MP0003315_abnormal_perineum_morphology3.02157127
12MP0005394_taste/olfaction_phenotype2.99503058
13MP0005499_abnormal_olfactory_system2.99503058
14MP0003077_abnormal_cell_cycle2.71506335
15* MP0001929_abnormal_gametogenesis2.71164010
16MP0003890_abnormal_embryonic-extraembry2.68744933
17MP0005646_abnormal_pituitary_gland2.68221964
18MP0004957_abnormal_blastocyst_morpholog2.67818135
19MP0000579_abnormal_nail_morphology2.65083642
20MP0003111_abnormal_nucleus_morphology2.55594564
21MP0000653_abnormal_sex_gland2.49764700
22MP0002138_abnormal_hepatobiliary_system2.39992814
23MP0002210_abnormal_sex_determination2.30432977
24MP0002295_abnormal_pulmonary_circulatio2.29084911
25MP0005187_abnormal_penis_morphology2.28525768
26MP0003121_genomic_imprinting1.99273472
27MP0010030_abnormal_orbit_morphology1.98950535
28MP0001919_abnormal_reproductive_system1.86894449
29MP0010307_abnormal_tumor_latency1.81296342
30* MP0002161_abnormal_fertility/fecundity1.79161966
31MP0005257_abnormal_intraocular_pressure1.78890158
32MP0000566_synostosis1.72645119
33MP0003879_abnormal_hair_cell1.69918188
34MP0005360_urolithiasis1.68957455
35MP0008932_abnormal_embryonic_tissue1.67059913
36MP0002234_abnormal_pharynx_morphology1.66670130
37MP0005410_abnormal_fertilization1.60810380
38MP0005389_reproductive_system_phenotype1.58656169
39MP0003950_abnormal_plasma_membrane1.53960368
40MP0003183_abnormal_peptide_metabolism1.52899949
41MP0003937_abnormal_limbs/digits/tail_de1.51570583
42MP0004859_abnormal_synaptic_plasticity1.49923254
43MP0009384_cardiac_valve_regurgitation1.48132920
44MP0001145_abnormal_male_reproductive1.45772859
45MP0010234_abnormal_vibrissa_follicle1.44541465
46MP0001905_abnormal_dopamine_level1.42857428
47MP0002249_abnormal_larynx_morphology1.40585833
48MP0008260_abnormal_autophagy1.40341121
49MP0003787_abnormal_imprinting1.39646924
50MP0006292_abnormal_olfactory_placode1.36353871
51MP0009840_abnormal_foam_cell1.22257799
52MP0006072_abnormal_retinal_apoptosis1.21863631
53MP0003123_paternal_imprinting1.20207697
54MP0001664_abnormal_digestion1.19916677
55MP0000631_abnormal_neuroendocrine_gland1.17899422
56MP0000350_abnormal_cell_proliferation1.15450347
57MP0005409_darkened_coat_color1.14135383
58MP0000613_abnormal_salivary_gland1.13563485
59MP0001529_abnormal_vocalization1.12647643
60MP0002102_abnormal_ear_morphology1.12519703
61MP0001666_abnormal_nutrient_absorption1.12394932
62MP0000465_gastrointestinal_hemorrhage1.11518321
63MP0003959_abnormal_lean_body1.09833856
64MP0003252_abnormal_bile_duct1.07342107
65MP0002282_abnormal_trachea_morphology1.06302831
66MP0010678_abnormal_skin_adnexa1.03314814
67MP0003119_abnormal_digestive_system1.01331342
68MP0002653_abnormal_ependyma_morphology1.01142717
69MP0002085_abnormal_embryonic_tissue1.00997016
70MP0001293_anophthalmia0.97321167
71MP0005408_hypopigmentation0.95285444
72MP0003868_abnormal_feces_composition0.91328682
73MP0003329_amyloid_beta_deposits0.90366815
74MP0000762_abnormal_tongue_morphology0.90250487
75MP0002233_abnormal_nose_morphology0.90083894
76MP0002932_abnormal_joint_morphology0.90015024
77MP0000733_abnormal_muscle_development0.89216619
78MP0002019_abnormal_tumor_incidence0.87315228
79MP0005076_abnormal_cell_differentiation0.86647822
80* MP0001730_embryonic_growth_arrest0.81727776
81* MP0005380_embryogenesis_phenotype0.80559894
82* MP0001672_abnormal_embryogenesis/_devel0.80559894
83MP0000383_abnormal_hair_follicle0.80431568
84MP0008875_abnormal_xenobiotic_pharmacok0.80146312
85MP0002269_muscular_atrophy0.78512474
86MP0009697_abnormal_copulation0.77749899
87MP0002089_abnormal_postnatal_growth/wei0.76690936
88MP0003698_abnormal_male_reproductive0.76207125
89MP0000678_abnormal_parathyroid_gland0.75622970
90MP0001984_abnormal_olfaction0.75050850
91MP0004036_abnormal_muscle_relaxation0.73995333
92MP0002272_abnormal_nervous_system0.71869441
93MP0003136_yellow_coat_color0.71191347
94MP0001697_abnormal_embryo_size0.70747090
95MP0002084_abnormal_developmental_patter0.69881363
96MP0003453_abnormal_keratinocyte_physiol0.68874994
97MP0005310_abnormal_salivary_gland0.68807085
98MP0004185_abnormal_adipocyte_glucose0.67366407
99MP0000639_abnormal_adrenal_gland0.65588918
100MP0002139_abnormal_hepatobiliary_system0.65065386
101MP0001986_abnormal_taste_sensitivity0.64137330
102MP0004264_abnormal_extraembryonic_tissu0.63383325
103MP0001346_abnormal_lacrimal_gland0.61146268
104MP0005085_abnormal_gallbladder_physiolo0.61078277
105MP0002332_abnormal_exercise_endurance0.60901911
106MP0010386_abnormal_urinary_bladder0.59715114
107MP0001324_abnormal_eye_pigmentation0.59504402
108MP0003806_abnormal_nucleotide_metabolis0.56824284
109MP0000470_abnormal_stomach_morphology0.56175416
110MP0001915_intracranial_hemorrhage0.55564735
111MP0002098_abnormal_vibrissa_morphology0.55282259
112MP0005621_abnormal_cell_physiology0.55268575
113MP0000049_abnormal_middle_ear0.54405908
114MP0002080_prenatal_lethality0.53896605
115MP0003935_abnormal_craniofacial_develop0.53813493
116MP0010368_abnormal_lymphatic_system0.53189199
117MP0003942_abnormal_urinary_system0.52138128
118MP0008058_abnormal_DNA_repair0.51929124
119MP0005397_hematopoietic_system_phenotyp0.51493334
120MP0001545_abnormal_hematopoietic_system0.51493334
121MP0005551_abnormal_eye_electrophysiolog0.51307914
122MP0001502_abnormal_circadian_rhythm0.50836748
123MP0002928_abnormal_bile_duct0.49986805
124MP0005197_abnormal_uvea_morphology0.49816856
125MP0003656_abnormal_erythrocyte_physiolo0.49794127
126MP0003763_abnormal_thymus_physiology0.49550951
127MP0001485_abnormal_pinna_reflex0.49413732
128MP0004233_abnormal_muscle_weight0.48409893
129MP0005647_abnormal_sex_gland0.48381206
130MP0004782_abnormal_surfactant_physiolog0.48226836
131MP0004142_abnormal_muscle_tone0.47802019
132MP0003755_abnormal_palate_morphology0.47794668
133MP0004484_altered_response_of0.47426960
134MP0000015_abnormal_ear_pigmentation0.47378597
135MP0005384_cellular_phenotype0.47003930
136MP0002177_abnormal_outer_ear0.44815053
137MP0000313_abnormal_cell_death0.44780957
138MP0002127_abnormal_cardiovascular_syste0.43904759
139MP0000490_abnormal_crypts_of0.43838960
140MP0000462_abnormal_digestive_system0.43379662
141MP0003861_abnormal_nervous_system0.43280977
142MP0003941_abnormal_skin_development0.43114711
143MP0006276_abnormal_autonomic_nervous0.42760915
144MP0002160_abnormal_reproductive_system0.42147437
145MP0000377_abnormal_hair_follicle0.41873122
146MP0008995_early_reproductive_senescence0.41625301
147MP0002108_abnormal_muscle_morphology0.41474728
148MP0006138_congestive_heart_failure0.40847717
149MP0009379_abnormal_foot_pigmentation0.40310395
150MP0008057_abnormal_DNA_replication0.39037923
151MP0003984_embryonic_growth_retardation0.38611689
152MP0008007_abnormal_cellular_replicative0.37987134
153MP0000427_abnormal_hair_cycle0.37638061
154MP0002088_abnormal_embryonic_growth/wei0.36067868
155MP0002837_dystrophic_cardiac_calcinosis0.35917604

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)8.35287617
2Male infertility (HP:0003251)6.95941040
3Infertility (HP:0000789)6.77426080
4Cortical dysplasia (HP:0002539)6.54045641
5Secondary amenorrhea (HP:0000869)5.36098482
6Abdominal situs inversus (HP:0003363)5.02476391
7Abnormality of abdominal situs (HP:0011620)5.02476391
8Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.87591692
9Deep venous thrombosis (HP:0002625)4.82470413
10Lip pit (HP:0100267)4.62609145
11Atelectasis (HP:0100750)4.53547114
12Chromsome breakage (HP:0040012)4.18334810
13Birth length less than 3rd percentile (HP:0003561)4.16292869
14Flat capital femoral epiphysis (HP:0003370)4.13726633
15Osteomalacia (HP:0002749)4.12305423
16Breast hypoplasia (HP:0003187)4.10461154
17Hypergonadotropic hypogonadism (HP:0000815)4.06119278
18Impulsivity (HP:0100710)3.87808613
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.87289422
20Pulmonary fibrosis (HP:0002206)3.85198518
21Anosmia (HP:0000458)3.81996048
22Rhabdomyosarcoma (HP:0002859)3.61718945
23Abnormality of the fovea (HP:0000493)3.50045938
24Hypophosphatemic rickets (HP:0004912)3.41660039
25Patellar aplasia (HP:0006443)3.38861667
26Septo-optic dysplasia (HP:0100842)3.38601320
27Abnormality of the labia minora (HP:0012880)3.32546058
28Cholecystitis (HP:0001082)3.31830659
29Abnormal gallbladder physiology (HP:0012438)3.31830659
30Hypoplasia of the fovea (HP:0007750)3.30017818
31Aplasia/Hypoplasia of the fovea (HP:0008060)3.30017818
32Insulin-resistant diabetes mellitus (HP:0000831)3.23692504
33Abnormality of chromosome segregation (HP:0002916)3.23354658
34Aplasia/Hypoplasia of the breasts (HP:0010311)3.23269384
35Hypogonadotrophic hypogonadism (HP:0000044)3.15446462
36Breast aplasia (HP:0100783)3.12345326
37Abnormality of the anterior chamber (HP:0000593)3.11178738
38Aplasia/Hypoplasia of the patella (HP:0006498)3.10554715
39Malnutrition (HP:0004395)3.09957403
40Adrenal hypoplasia (HP:0000835)3.08761000
41Aplasia of the musculature (HP:0100854)3.05419797
42Hypokinesia (HP:0002375)2.93857907
43Azoospermia (HP:0000027)2.91100170
44Primary amenorrhea (HP:0000786)2.89988871
45Combined immunodeficiency (HP:0005387)2.89977820
46Carpal bone hypoplasia (HP:0001498)2.85331596
47Shawl scrotum (HP:0000049)2.81149723
48Thyroid carcinoma (HP:0002890)2.75718000
49Abnormality of the proximal phalanges of the hand (HP:0009834)2.73954502
50Abnormality of placental membranes (HP:0011409)2.73088822
51Amniotic constriction ring (HP:0009775)2.73088822
52Truncal obesity (HP:0001956)2.69411927
53Myokymia (HP:0002411)2.67979229
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.64617232
55Papillary thyroid carcinoma (HP:0002895)2.61992183
56Anterior segment dysgenesis (HP:0007700)2.61339183
57Gonadotropin excess (HP:0000837)2.59701745
58Facial hemangioma (HP:0000329)2.59079773
59Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.55454756
60Anhidrosis (HP:0000970)2.54216601
61Apathy (HP:0000741)2.51820625
62Obstructive sleep apnea (HP:0002870)2.49572317
63Oligodactyly (HP:0012165)2.47716982
64Neoplasm of striated muscle (HP:0009728)2.44247624
65Lower limb hyperreflexia (HP:0002395)2.41709589
66Loss of speech (HP:0002371)2.41550513
67Aplasia/Hypoplasia of the sternum (HP:0006714)2.41139813
68Cone-rod dystrophy (HP:0000548)2.40868875
69Aplasia/Hypoplasia involving the musculature (HP:0001460)2.38337124
70Supranuclear gaze palsy (HP:0000605)2.37433016
71Diminished motivation (HP:0000745)2.36762301
72Absent septum pellucidum (HP:0001331)2.36630601
73Arterial tortuosity (HP:0005116)2.36451759
74Fetal akinesia sequence (HP:0001989)2.34771778
75Small intestinal stenosis (HP:0012848)2.34465052
76Duodenal stenosis (HP:0100867)2.34465052
77Abnormal lung lobation (HP:0002101)2.32621805
78Urethral obstruction (HP:0000796)2.32458219
79Delayed puberty (HP:0000823)2.32130452
80Nonprogressive disorder (HP:0003680)2.30574254
81Neurofibrillary tangles (HP:0002185)2.29349754
82Capillary hemangiomas (HP:0005306)2.29162915
83Median cleft lip (HP:0000161)2.25846697
84Supernumerary spleens (HP:0009799)2.25272913
85Posterior embryotoxon (HP:0000627)2.24781881
86Hyperglycemia (HP:0003074)2.22684549
87Bundle branch block (HP:0011710)2.21129526
88Sloping forehead (HP:0000340)2.20923314
89Abnormality of alanine metabolism (HP:0010916)2.18635099
90Hyperalaninemia (HP:0003348)2.18635099
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18635099
92Metaphyseal irregularity (HP:0003025)2.17551720
93Spinal cord compression (HP:0002176)2.16403250
94Abnormal spermatogenesis (HP:0008669)2.14774243
95Skin pits (HP:0100276)2.14773253
96Villous atrophy (HP:0011473)2.14417859
97Abnormality of small intestinal villus morphology (HP:0011472)2.14417859
98Abnormality of the line of Schwalbe (HP:0008048)2.12901070
99Oligodactyly (hands) (HP:0001180)2.12666956
100Congenital sensorineural hearing impairment (HP:0008527)2.11891798
101Aplasia/Hypoplasia of the macula (HP:0008059)2.11311064
102Increased circulating renin level (HP:0000848)2.10279378
103Absent radius (HP:0003974)2.07217665
104Dysdiadochokinesis (HP:0002075)2.06503792
105Absent forearm bone (HP:0003953)2.04907383
106Aplasia involving forearm bones (HP:0009822)2.04907383
107Subcapsular cataract (HP:0000523)2.04731189
108Muscle fiber splitting (HP:0003555)2.04208334
109Oral leukoplakia (HP:0002745)2.02981263
110Nephroblastoma (Wilms tumor) (HP:0002667)2.02882510
111Vascular tortuosity (HP:0004948)2.00863035
112Fair hair (HP:0002286)2.00566159
113Abnormality of the septum pellucidum (HP:0007375)2.00458027
114Fibular aplasia (HP:0002990)1.98802144
115Papilledema (HP:0001085)1.98422903
116Dysmetric saccades (HP:0000641)1.96841100
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96648938
118Abnormality of the epiphysis of the femoral head (HP:0010574)1.95836425
119Striae distensae (HP:0001065)1.93011969
120Maternal diabetes (HP:0009800)1.92905570
121Aplasia/Hypoplasia affecting the retina (HP:0008061)1.92534290
122Irregular epiphyses (HP:0010582)1.91249101
123Abnormality of the salivary glands (HP:0010286)1.91146494
124Tubulointerstitial nephritis (HP:0001970)1.90784541
125Absent hand (HP:0004050)1.88988095
126Bronchiectasis (HP:0002110)1.88064855
127Embryonal renal neoplasm (HP:0011794)1.86663240
128Sandal gap (HP:0001852)1.86312185
129Abnormality of chromosome stability (HP:0003220)1.86085815
130Muscle fiber atrophy (HP:0100295)1.85919836
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84745813
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.84664217
133Arachnodactyly (HP:0001166)1.83849019
134Enlarged penis (HP:0000040)1.82126802
135Type 2 muscle fiber atrophy (HP:0003554)1.81444108
136Abnormality of the femoral head (HP:0003368)1.80653043
137Non-midline cleft lip (HP:0100335)1.80119631
138Wrist flexion contracture (HP:0001239)1.80070843
139Abnormality of cochlea (HP:0000375)1.79993838
140Aplastic anemia (HP:0001915)1.79928935
141Short tibia (HP:0005736)1.79598876
142Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.79142724
143Progressive sensorineural hearing impairment (HP:0000408)1.78991246
144Intrahepatic cholestasis (HP:0001406)1.77536765
145Aplasia involving bones of the upper limbs (HP:0009823)1.76434186
146Aplasia of the phalanges of the hand (HP:0009802)1.76434186
147Aplasia involving bones of the extremities (HP:0009825)1.76434186
148Abnormality of femoral epiphyses (HP:0006499)1.75035565
149Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.75035565
150Abnormality of the preputium (HP:0100587)1.74378855
151Hypercortisolism (HP:0001578)1.72257298
152Hydroureter (HP:0000072)1.70436928
153Spinal muscular atrophy (HP:0007269)1.68260727
154Decreased circulating renin level (HP:0003351)1.67719938
155Limb hypertonia (HP:0002509)1.66816596
156Hip contracture (HP:0003273)1.66254619
157Leiomyosarcoma (HP:0100243)1.65503067
158Uterine leiomyosarcoma (HP:0002891)1.65503067
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.64638733
160Abnormality of monocarboxylic acid metabolism (HP:0010996)1.62962821
161Hyperactive renin-angiotensin system (HP:0000841)1.62752279
162Shallow orbits (HP:0000586)1.61973666
163Pili torti (HP:0003777)1.61972065
164Meckel diverticulum (HP:0002245)1.61229333
165Prolonged neonatal jaundice (HP:0006579)1.61113529

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.22234142
2MAP3K65.56697762
3TTK4.51110569
4ERBB43.89013903
5TAOK33.56248351
6STK103.30178932
7BRAF3.19518062
8EEF2K3.13394239
9LATS22.92760350
10CAMK1D2.92683958
11PRKD32.86751783
12KSR22.73024562
13NEK62.68974059
14PLK42.68234978
15MOS2.58437428
16LATS12.52798732
17MET2.38639321
18MAP3K92.33246429
19CHEK22.26528113
20BMPR22.11872262
21CDK82.04910161
22CAMK1G2.03593214
23MUSK1.99503071
24MELK1.92384471
25BRD41.82428979
26TRIM281.80985924
27BUB11.80856733
28STK38L1.74149135
29PLK11.69585894
30MAPKAPK31.68186184
31MAP3K81.65290058
32MAPKAPK51.59968518
33NEK21.59876793
34MAP3K131.54739837
35WNK11.52087832
36STK31.49080308
37TNIK1.48675564
38ARAF1.42973898
39CDC71.34979803
40AURKA1.32556697
41TAOK11.29261445
42MAPK131.28356507
43MAP3K41.25930246
44TGFBR11.25331429
45PRKCI1.22828624
46MTOR1.18504648
47PTK21.14745067
48MAP2K71.11541773
49ERN11.02222588
50EIF2AK10.99315788
51DYRK20.96654609
52AURKB0.95343321
53CSNK1G10.94581933
54RAF10.90285587
55PAK60.86743431
56RET0.84159347
57CSNK1G30.79082170
58ICK0.77943232
59PRKD20.76888800
60STK240.74591389
61MARK30.73119146
62CDC42BPA0.72888363
63ZAP700.72026858
64MAP3K20.71470288
65CAMK40.71420911
66MAP2K40.69211604
67MST40.69201022
68PINK10.68378887
69CSNK1G20.66943571
70PRKAA10.65441281
71ACVR1B0.64844361
72PLK30.63839764
73PRKCZ0.61606692
74TNK20.61015281
75ABL20.59578472
76TRPM70.59276706
77ZAK0.58620002
78LRRK20.58431542
79CSNK1A1L0.57269079
80MARK20.56901084
81CDK90.56829414
82MAPK110.56071798
83RPS6KB20.54540917
84NME10.54284287
85CHEK10.49042074
86MAPK100.48445672
87STK390.47864426
88MAP3K50.46969378
89TESK20.46782515
90CDK190.46268096
91CDK50.45886623
92DMPK0.45816584
93GSK3B0.44649374
94MAP3K70.44378768
95ATM0.43045460
96KSR10.42986778
97PRKAA20.42729035
98TLK10.42445864
99TYRO30.40013567
100CAMK10.39710219
101NTRK20.39506837
102CLK10.39080830
103MAPK10.39052201
104CDK10.39040893
105STK380.38460361
106CDK40.37593183
107EPHA40.37531162
108PDK40.37410048
109PDK30.37410048
110BMPR1B0.36812488
111PLK20.36226437
112BRSK10.35597705
113CSNK1D0.35314471
114NTRK30.35214786
115TIE10.34930250
116PKN10.33952681
117BRSK20.33465222
118NLK0.33300988
119ATR0.32901132
120MAP3K10.32541900
121CDK70.32259917
122ABL10.31985981
123PRKG10.31717914
124PDK10.30770613
125EIF2AK30.30327121
126NEK90.30235648
127NEK10.29988381
128RPS6KB10.29048578
129TAOK20.28682771
130CDK20.28634729
131MAPK140.28044904
132CHUK0.27416456
133WEE10.25844401
134VRK10.24426294
135AKT20.24330858
136PAK10.21939184
137NTRK10.21649956
138RPS6KA40.21305375
139FLT30.21073191
140STK110.18906151
141CSNK1A10.18261338
142AKT10.16902380
143MAP2K20.16901137
144ADRBK10.15592788
145CSNK1E0.13554721
146RPS6KA10.12844159
147CDK30.11400981
148MAP2K10.11371035
149SGK4940.11283669
150SGK2230.11283669
151PIM10.09678704

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.06458534
2Ovarian steroidogenesis_Homo sapiens_hsa049134.79862552
3Cell cycle_Homo sapiens_hsa041103.56240512
4Basal transcription factors_Homo sapiens_hsa030223.18644532
5RNA degradation_Homo sapiens_hsa030182.94165752
6Homologous recombination_Homo sapiens_hsa034402.61063533
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.54929103
8Oocyte meiosis_Homo sapiens_hsa041142.43272208
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39769642
10RNA transport_Homo sapiens_hsa030132.39095797
11Fanconi anemia pathway_Homo sapiens_hsa034602.38747691
12RNA polymerase_Homo sapiens_hsa030202.26625667
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.24069028
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.23601108
15Linoleic acid metabolism_Homo sapiens_hsa005912.15297147
16Dorso-ventral axis formation_Homo sapiens_hsa043202.00442297
17Ether lipid metabolism_Homo sapiens_hsa005651.89284900
18Base excision repair_Homo sapiens_hsa034101.88541172
19GnRH signaling pathway_Homo sapiens_hsa049121.88049223
20Circadian rhythm_Homo sapiens_hsa047101.84725951
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.80986075
22Pancreatic cancer_Homo sapiens_hsa052121.63592954
23Non-homologous end-joining_Homo sapiens_hsa034501.54549725
24mTOR signaling pathway_Homo sapiens_hsa041501.50800089
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.46636070
26Caffeine metabolism_Homo sapiens_hsa002321.39028886
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38724884
28MicroRNAs in cancer_Homo sapiens_hsa052061.35814955
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35327862
30Mismatch repair_Homo sapiens_hsa034301.32184259
31DNA replication_Homo sapiens_hsa030301.27181028
32p53 signaling pathway_Homo sapiens_hsa041151.24769702
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20238600
34Nucleotide excision repair_Homo sapiens_hsa034201.16310738
35mRNA surveillance pathway_Homo sapiens_hsa030151.15020890
36Olfactory transduction_Homo sapiens_hsa047401.13191255
37Inositol phosphate metabolism_Homo sapiens_hsa005621.10506106
38ABC transporters_Homo sapiens_hsa020101.08550153
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08212253
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03162287
41Regulation of autophagy_Homo sapiens_hsa041401.00927515
42Phototransduction_Homo sapiens_hsa047440.99858610
43Colorectal cancer_Homo sapiens_hsa052100.98873332
44VEGF signaling pathway_Homo sapiens_hsa043700.98668230
45Choline metabolism in cancer_Homo sapiens_hsa052310.97409085
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96808926
47GABAergic synapse_Homo sapiens_hsa047270.94974823
48Purine metabolism_Homo sapiens_hsa002300.94703133
49Bile secretion_Homo sapiens_hsa049760.94295457
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92859215
51Other glycan degradation_Homo sapiens_hsa005110.89438628
52Renal cell carcinoma_Homo sapiens_hsa052110.87703731
53Prolactin signaling pathway_Homo sapiens_hsa049170.87522894
54TGF-beta signaling pathway_Homo sapiens_hsa043500.83203792
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82917064
56Long-term depression_Homo sapiens_hsa047300.81661723
57Pyrimidine metabolism_Homo sapiens_hsa002400.79289917
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71352892
59Pyruvate metabolism_Homo sapiens_hsa006200.70876907
60Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69659280
61Bladder cancer_Homo sapiens_hsa052190.67991165
62Phagosome_Homo sapiens_hsa041450.66344176
63Wnt signaling pathway_Homo sapiens_hsa043100.66209958
64Morphine addiction_Homo sapiens_hsa050320.64807933
65Herpes simplex infection_Homo sapiens_hsa051680.63406116
66Arginine and proline metabolism_Homo sapiens_hsa003300.63022029
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61878767
68Folate biosynthesis_Homo sapiens_hsa007900.59619037
69Arginine biosynthesis_Homo sapiens_hsa002200.59208864
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58788993
71Hippo signaling pathway_Homo sapiens_hsa043900.57827988
72Taste transduction_Homo sapiens_hsa047420.55895860
73Ras signaling pathway_Homo sapiens_hsa040140.55283942
74ErbB signaling pathway_Homo sapiens_hsa040120.54019051
75FoxO signaling pathway_Homo sapiens_hsa040680.52802036
76Nicotine addiction_Homo sapiens_hsa050330.50335110
77Steroid biosynthesis_Homo sapiens_hsa001000.50179855
78Non-small cell lung cancer_Homo sapiens_hsa052230.49288889
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.47707405
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46706313
81Arachidonic acid metabolism_Homo sapiens_hsa005900.44386768
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44187932
83Influenza A_Homo sapiens_hsa051640.42591612
84Prostate cancer_Homo sapiens_hsa052150.41485917
85Vitamin digestion and absorption_Homo sapiens_hsa049770.40233234
86Synaptic vesicle cycle_Homo sapiens_hsa047210.39499178
87Histidine metabolism_Homo sapiens_hsa003400.37671964
88Endometrial cancer_Homo sapiens_hsa052130.37356382
89beta-Alanine metabolism_Homo sapiens_hsa004100.37259934
90HTLV-I infection_Homo sapiens_hsa051660.37218843
91Gap junction_Homo sapiens_hsa045400.36037114
92cAMP signaling pathway_Homo sapiens_hsa040240.35589986
93Estrogen signaling pathway_Homo sapiens_hsa049150.34729250
94Amoebiasis_Homo sapiens_hsa051460.34117855
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33938896
96Sphingolipid metabolism_Homo sapiens_hsa006000.33288561
97Melanoma_Homo sapiens_hsa052180.33080606
98Thyroid cancer_Homo sapiens_hsa052160.32130281
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.31599399
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30963183
101Chronic myeloid leukemia_Homo sapiens_hsa052200.30743530
102Glioma_Homo sapiens_hsa052140.30229662
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30212480
104Melanogenesis_Homo sapiens_hsa049160.29897598
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.29886079
106Long-term potentiation_Homo sapiens_hsa047200.29645673
107Shigellosis_Homo sapiens_hsa051310.29411349
108Cholinergic synapse_Homo sapiens_hsa047250.28162743
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27774153
110Protein digestion and absorption_Homo sapiens_hsa049740.27222877
111Complement and coagulation cascades_Homo sapiens_hsa046100.24319177
112HIF-1 signaling pathway_Homo sapiens_hsa040660.24230173
113Insulin signaling pathway_Homo sapiens_hsa049100.23392092
114Huntingtons disease_Homo sapiens_hsa050160.23105594
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22550110
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22357812
117Peroxisome_Homo sapiens_hsa041460.22189248
118Glutamatergic synapse_Homo sapiens_hsa047240.21997398
119Adherens junction_Homo sapiens_hsa045200.21778631
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21647168
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.21401140
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21210930
123Circadian entrainment_Homo sapiens_hsa047130.20439378
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.20231449
125Viral carcinogenesis_Homo sapiens_hsa052030.19305208
126Glycerolipid metabolism_Homo sapiens_hsa005610.19084820
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18793336
128Propanoate metabolism_Homo sapiens_hsa006400.18429387
129Lysine degradation_Homo sapiens_hsa003100.18243938
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.17764583
131MAPK signaling pathway_Homo sapiens_hsa040100.16169459
132Apoptosis_Homo sapiens_hsa042100.16012194
133Endocytosis_Homo sapiens_hsa041440.15736961
134Small cell lung cancer_Homo sapiens_hsa052220.15426672
135Serotonergic synapse_Homo sapiens_hsa047260.14755687
136Rap1 signaling pathway_Homo sapiens_hsa040150.14564834
137Notch signaling pathway_Homo sapiens_hsa043300.14237475
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14062684
139Insulin secretion_Homo sapiens_hsa049110.13819766
140Calcium signaling pathway_Homo sapiens_hsa040200.13779205
141Pathways in cancer_Homo sapiens_hsa052000.13770040
142Hepatitis B_Homo sapiens_hsa051610.13160674

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