PAEP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)9.61671384
2melanin metabolic process (GO:0006582)8.71747688
3secondary metabolite biosynthetic process (GO:0044550)8.28507262
4tyrosine metabolic process (GO:0006570)6.83280346
5complement activation, alternative pathway (GO:0006957)6.72176140
6response to dietary excess (GO:0002021)6.26429726
7regulation of complement activation (GO:0030449)5.54506499
8C4-dicarboxylate transport (GO:0015740)5.52144666
9regulation of protein activation cascade (GO:2000257)5.33549198
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.33233778
11regulation of cholesterol esterification (GO:0010872)5.32529126
12negative regulation of glycoprotein metabolic process (GO:1903019)5.30060755
13prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060525.18513924
14negative regulation of glycoprotein biosynthetic process (GO:0010561)5.16007324
15neurotransmitter catabolic process (GO:0042135)4.95678644
16pigment cell differentiation (GO:0050931)4.93930216
17melanocyte differentiation (GO:0030318)4.84897162
18parturition (GO:0007567)4.60558902
19prostate gland growth (GO:0060736)4.50658813
20glomerular filtration (GO:0003094)4.50481226
21cellular response to reactive nitrogen species (GO:1902170)4.46291670
22basement membrane organization (GO:0071711)4.43175440
23insulin-like growth factor receptor signaling pathway (GO:0048009)4.37940519
24regulation of lipoprotein metabolic process (GO:0050746)4.37123018
25sexual reproduction (GO:0019953)4.35845418
26regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.35189126
27negative regulation of protein activation cascade (GO:2000258)4.27587888
28lung lobe morphogenesis (GO:0060463)4.27550760
29complement activation, classical pathway (GO:0006958)4.26686512
30neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)4.26038259
31macroautophagy (GO:0016236)4.19012104
32amyloid precursor protein metabolic process (GO:0042982)4.17237723
33renal filtration (GO:0097205)4.10859049
34response to phenylpropanoid (GO:0080184)4.07474794
35negative regulation of complement activation (GO:0045916)4.06393867
36basic amino acid transport (GO:0015802)4.04823714
37positive regulation of cardiac muscle hypertrophy (GO:0010613)3.97367011
38positive regulation of muscle hypertrophy (GO:0014742)3.97367011
39high-density lipoprotein particle remodeling (GO:0034375)3.94977551
40exocrine pancreas development (GO:0031017)3.92910271
41aromatic amino acid family metabolic process (GO:0009072)3.89926212
42positive regulation of developmental pigmentation (GO:0048087)3.89561739
43phospholipid efflux (GO:0033700)3.88977772
44nephron tubule formation (GO:0072079)3.83152122
45regulation of triglyceride catabolic process (GO:0010896)3.72566590
46lung vasculature development (GO:0060426)3.71089387
47chondroitin sulfate catabolic process (GO:0030207)3.70103156
48mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.63085383
49cellular response to nitric oxide (GO:0071732)3.61599211
50positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.60696383
51complement activation (GO:0006956)3.53363857
52phenol-containing compound biosynthetic process (GO:0046189)3.52809166
53reverse cholesterol transport (GO:0043691)3.49967950
54L-amino acid import (GO:0043092)3.45637397
55interleukin-6-mediated signaling pathway (GO:0070102)3.43107755
56fibroblast migration (GO:0010761)3.42740171
57negative regulation of metanephros development (GO:0072217)3.42252529
58regulation of apoptotic process involved in morphogenesis (GO:1902337)3.36202822
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.34503178
60L-phenylalanine metabolic process (GO:0006558)3.34503178
61membrane protein ectodomain proteolysis (GO:0006509)3.34480691
62regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.31131046
63neurotransmitter biosynthetic process (GO:0042136)3.20624161
64positive regulation of smooth muscle cell migration (GO:0014911)3.20213637
65interleukin-1-mediated signaling pathway (GO:0070498)3.16350168
66amyloid precursor protein catabolic process (GO:0042987)3.14060349
67positive regulation of glycolytic process (GO:0045821)3.13498325
68positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.12172141
69L-phenylalanine catabolic process (GO:0006559)3.11924257
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.11924257
71neuroepithelial cell differentiation (GO:0060563)3.11247206
72regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.08979447
73detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08463640
74cytolysis (GO:0019835)3.02792697
75cholesterol efflux (GO:0033344)3.00829583
76regulation of humoral immune response (GO:0002920)3.00253959
77GDP-mannose metabolic process (GO:0019673)2.95494063
78regulation of cardiac muscle hypertrophy (GO:0010611)2.94850457
79aromatic amino acid family catabolic process (GO:0009074)2.93880412
80branching involved in prostate gland morphogenesis (GO:0060442)2.93344861
81forebrain morphogenesis (GO:0048853)2.92962317
82endosome to melanosome transport (GO:0035646)2.91587911
83endosome to pigment granule transport (GO:0043485)2.91587911
84positive regulation of triglyceride lipase activity (GO:0061365)2.91545183
85positive regulation of lipoprotein lipase activity (GO:0051006)2.91545183
86positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.91200915
87peptidyl-proline hydroxylation (GO:0019511)2.89718950
88glomerular basement membrane development (GO:0032836)2.89018253
89protein activation cascade (GO:0072376)2.88660148
90regulation of muscle hypertrophy (GO:0014743)2.88263938
91positive regulation of hormone metabolic process (GO:0032352)2.87063384
92lung secretory cell differentiation (GO:0061140)2.86910393
93negative regulation of macroautophagy (GO:0016242)2.86742683
94gland morphogenesis (GO:0022612)2.86248530
95negative regulation of humoral immune response (GO:0002921)2.85471742
96growth hormone receptor signaling pathway (GO:0060396)2.82857280
97indolalkylamine catabolic process (GO:0046218)2.77841440
98tryptophan catabolic process (GO:0006569)2.77841440
99indole-containing compound catabolic process (GO:0042436)2.77841440
100morphogenesis of an epithelial fold (GO:0060571)2.77136779

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.05918877
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.36409881
3GATA1_22025678_ChIP-Seq_K562_Human2.89496414
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.85772417
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.83454308
6AR_21572438_ChIP-Seq_LNCaP_Human2.48552929
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.34546905
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.32871733
9ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.32656021
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.28435721
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.02112057
12GATA2_21666600_ChIP-Seq_HMVEC_Human2.00164212
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97711900
14GBX2_23144817_ChIP-Seq_PC3_Human1.95308763
15ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91913642
16ZNF274_21170338_ChIP-Seq_K562_Hela1.79672962
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.73540826
18VDR_22108803_ChIP-Seq_LS180_Human1.72244402
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71493418
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.58379468
21BCAT_22108803_ChIP-Seq_LS180_Human1.58330168
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55699999
23TCF4_22108803_ChIP-Seq_LS180_Human1.54676026
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.53951569
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.52895239
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38680678
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.37484100
28LXR_22158963_ChIP-Seq_LIVER_Mouse1.37164456
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32855801
30PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31989874
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.28423254
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.24305693
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24205318
34AHR_22903824_ChIP-Seq_MCF-7_Human1.23376810
35MITF_21258399_ChIP-Seq_MELANOMA_Human1.22129276
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.20869467
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20865119
38FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20806437
39CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20328720
40RXR_22108803_ChIP-Seq_LS180_Human1.18233865
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15764403
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14077547
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12546298
44CDX2_22108803_ChIP-Seq_LS180_Human1.08175165
45P300_19829295_ChIP-Seq_ESCs_Human1.07906061
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07524086
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07304715
48CBP_20019798_ChIP-Seq_JUKART_Human1.07304715
49JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06746828
50SMAD4_21799915_ChIP-Seq_A2780_Human1.06689812
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06613373
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.06507896
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05234561
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05122706
55SOX2_20726797_ChIP-Seq_SW620_Human1.03546966
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03078707
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01883252
58ER_23166858_ChIP-Seq_MCF-7_Human1.01186174
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00596745
60SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99938669
61AR_25329375_ChIP-Seq_VCAP_Human0.99628543
62TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99104234
63IRF8_22096565_ChIP-ChIP_GC-B_Human0.98392135
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97821686
65TCF4_23295773_ChIP-Seq_U87_Human0.97352360
66NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96984562
67SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96870315
68GATA4_25053715_ChIP-Seq_YYC3_Human0.96675136
69FOXO3_23340844_ChIP-Seq_DLD1_Human0.95665990
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95288835
71FLI1_21867929_ChIP-Seq_TH2_Mouse0.95148263
72NRF2_20460467_ChIP-Seq_MEFs_Mouse0.94072351
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.94072351
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93241283
75RUNX2_22187159_ChIP-Seq_PCA_Human0.92749719
76EZH2_27294783_Chip-Seq_ESCs_Mouse0.92271080
77HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92081474
78GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.91964555
79CDX2_20551321_ChIP-Seq_CACO-2_Human0.91539255
80EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.91288943
81HOXB7_26014856_ChIP-Seq_BT474_Human0.90967522
82FOXH1_21741376_ChIP-Seq_ESCs_Human0.90707769
83TP53_16413492_ChIP-PET_HCT116_Human0.89428794
84JUN_21703547_ChIP-Seq_K562_Human0.89303221
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89038217
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88757332
87RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88378634
88TP53_18474530_ChIP-ChIP_U2OS_Human0.88091809
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87438647
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87359732
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86597253
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85533529
93STAT3_23295773_ChIP-Seq_U87_Human0.84816609
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.82781811
95ERA_21632823_ChIP-Seq_H3396_Human0.82592655
96HNF4A_19822575_ChIP-Seq_HepG2_Human0.81788673
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81511362
98CJUN_26792858_Chip-Seq_BT549_Human0.81225955
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80665003
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.80664650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation8.14863025
2MP0003136_yellow_coat_color7.76298741
3MP0000372_irregular_coat_pigmentation6.55886982
4MP0005408_hypopigmentation5.38856290
5MP0005257_abnormal_intraocular_pressure5.05654570
6MP0004381_abnormal_hair_follicle3.53478466
7MP0009840_abnormal_foam_cell3.25928393
8MP0005075_abnormal_melanosome_morpholog3.12858243
9MP0002254_reproductive_system_inflammat3.11224556
10MP0000015_abnormal_ear_pigmentation3.06792451
11MP0005409_darkened_coat_color2.83451289
12MP0002877_abnormal_melanocyte_morpholog2.80524747
13MP0000371_diluted_coat_color2.56917116
14MP0002095_abnormal_skin_pigmentation2.51355659
15MP0008438_abnormal_cutaneous_collagen2.17873793
16MP0002089_abnormal_postnatal_growth/wei2.10297853
17MP0010386_abnormal_urinary_bladder1.97292826
18MP0004272_abnormal_basement_membrane1.84174919
19MP0005058_abnormal_lysosome_morphology1.74585757
20MP0002075_abnormal_coat/hair_pigmentati1.74430271
21MP0008004_abnormal_stomach_pH1.72250333
22MP0005174_abnormal_tail_pigmentation1.67823648
23MP0002938_white_spotting1.43146564
24MP0001502_abnormal_circadian_rhythm1.42831221
25MP0001186_pigmentation_phenotype1.31268408
26MP0006054_spinal_hemorrhage1.29847297
27MP0003172_abnormal_lysosome_physiology1.29133664
28MP0000467_abnormal_esophagus_morphology1.19947134
29MP0001324_abnormal_eye_pigmentation1.11704803
30MP0008872_abnormal_physiological_respon1.06984658
31MP0000604_amyloidosis1.06583466
32MP0001881_abnormal_mammary_gland1.06421233
33MP0002090_abnormal_vision1.00625115
34MP0010329_abnormal_lipoprotein_level0.99521401
35MP0004264_abnormal_extraembryonic_tissu0.98993328
36MP0001542_abnormal_bone_strength0.97441359
37MP0000920_abnormal_myelination0.95060132
38MP0000383_abnormal_hair_follicle0.94903221
39MP0001661_extended_life_span0.90991765
40MP0003879_abnormal_hair_cell0.85504139
41MP0003638_abnormal_response/metabolism_0.84881682
42MP0003011_delayed_dark_adaptation0.84695827
43MP0006276_abnormal_autonomic_nervous0.81685252
44MP0002177_abnormal_outer_ear0.81285009
45MP0005248_abnormal_Harderian_gland0.75091637
46MP0005389_reproductive_system_phenotype0.71498722
47MP0002638_abnormal_pupillary_reflex0.71419114
48MP0005253_abnormal_eye_physiology0.71133181
49MP0005595_abnormal_vascular_smooth0.70014638
50MP0002160_abnormal_reproductive_system0.66506617
51MP0002060_abnormal_skin_morphology0.66322536
52MP0001849_ear_inflammation0.64921430
53MP0002876_abnormal_thyroid_physiology0.64694181
54MP0008961_abnormal_basal_metabolism0.61401653
55MP0000639_abnormal_adrenal_gland0.61312450
56MP0005646_abnormal_pituitary_gland0.60896931
57MP0004147_increased_porphyrin_level0.60451737
58MP0009379_abnormal_foot_pigmentation0.59664493
59MP0009053_abnormal_anal_canal0.58560614
60MP0005167_abnormal_blood-brain_barrier0.58393498
61MP0003724_increased_susceptibility_to0.55937269
62MP0010678_abnormal_skin_adnexa0.55077085
63MP0005503_abnormal_tendon_morphology0.54729167
64MP0003938_abnormal_ear_development0.53786079
65MP0002108_abnormal_muscle_morphology0.52520186
66MP0009384_cardiac_valve_regurgitation0.51638050
67MP0003633_abnormal_nervous_system0.51636177
68MP0002933_joint_inflammation0.50132543
69MP0005379_endocrine/exocrine_gland_phen0.49838898
70MP0003634_abnormal_glial_cell0.49283646
71MP0005551_abnormal_eye_electrophysiolog0.48595601
72MP0002970_abnormal_white_adipose0.48393285
73MP0002098_abnormal_vibrissa_morphology0.47480989
74MP0000579_abnormal_nail_morphology0.47040980
75MP0001299_abnormal_eye_distance/0.46645243
76MP0003632_abnormal_nervous_system0.46328410
77MP0001873_stomach_inflammation0.46260987
78MP0001348_abnormal_lacrimal_gland0.46038581
79MP0001919_abnormal_reproductive_system0.45030381
80MP0000343_altered_response_to0.41959659
81MP0001963_abnormal_hearing_physiology0.39998854
82MP0002229_neurodegeneration0.39713086
83MP0000427_abnormal_hair_cycle0.37942280
84MP0009643_abnormal_urine_homeostasis0.37536426
85MP0001984_abnormal_olfaction0.37062239
86MP0003631_nervous_system_phenotype0.36935962
87MP0002557_abnormal_social/conspecific_i0.34451849
88MP0000767_abnormal_smooth_muscle0.33877567
89MP0001529_abnormal_vocalization0.33360939
90MP0000026_abnormal_inner_ear0.32802200
91MP0002751_abnormal_autonomic_nervous0.32157874
92MP0002735_abnormal_chemical_nociception0.32070425
93MP0000230_abnormal_systemic_arterial0.31709961
94MP0000569_abnormal_digit_pigmentation0.31623322
95MP0000358_abnormal_cell_content/0.31524704
96MP0005164_abnormal_response_to0.31521348
97MP0005197_abnormal_uvea_morphology0.31367524
98MP0002184_abnormal_innervation0.31330094
99MP0002998_abnormal_bone_remodeling0.31123219
100MP0005670_abnormal_white_adipose0.30596203

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fovea (HP:0000493)8.44678403
2Aplasia/Hypoplasia of the macula (HP:0008059)7.78946270
3Aplasia/Hypoplasia affecting the retina (HP:0008061)7.31984616
4Blue irides (HP:0000635)7.11398116
5White forelock (HP:0002211)5.83516110
6Ocular albinism (HP:0001107)5.41139785
7Patchy hypopigmentation of hair (HP:0011365)5.29845609
8Iris hypopigmentation (HP:0007730)4.65126152
9J-shaped sella turcica (HP:0002680)4.59468616
10Hypopigmentation of the fundus (HP:0007894)4.43105404
11Hypoplasia of the iris (HP:0007676)4.04801789
12Generalized hypopigmentation of hair (HP:0011358)3.85135769
13Generalized hypopigmentation (HP:0007513)3.77932448
14Paraparesis (HP:0002385)3.72078469
15Retinal atrophy (HP:0001105)3.49543459
16Anterior segment dysgenesis (HP:0007700)3.46342333
17Abnormality of liposaccharide metabolism (HP:0010968)3.45279795
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.45279795
19Abnormality of glycolipid metabolism (HP:0010969)3.45279795
20Neurofibrillary tangles (HP:0002185)3.40214249
21Increased neuronal autofluorescent lipopigment (HP:0002074)3.38136337
22Loss of speech (HP:0002371)3.34149395
23Increased cerebral lipofuscin (HP:0011813)3.26705906
24Spastic paraparesis (HP:0002313)3.07892652
25Congenital sensorineural hearing impairment (HP:0008527)2.97138577
26Deformed sella turcica (HP:0002681)2.87346040
27Hypothermia (HP:0002045)2.85295873
28Popliteal pterygium (HP:0009756)2.75558307
29Clumsiness (HP:0002312)2.74424395
30Bilateral sensorineural hearing impairment (HP:0008619)2.73126253
31Albinism (HP:0001022)2.73006565
32Mitral stenosis (HP:0001718)2.72373399
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.67756039
34Heterochromia iridis (HP:0001100)2.64357567
35Absent eyebrow (HP:0002223)2.60117921
36Dysostosis multiplex (HP:0000943)2.59851120
37Abnormal glucose tolerance (HP:0001952)2.56372066
38Systemic lupus erythematosus (HP:0002725)2.54800046
39Neurodegeneration (HP:0002180)2.54170058
40Glomerulonephritis (HP:0000099)2.54123532
41Large eyes (HP:0001090)2.53461137
42Complement deficiency (HP:0004431)2.52833703
43Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.41693973
44Thyroid-stimulating hormone excess (HP:0002925)2.35645312
45Esophageal neoplasm (HP:0100751)2.34945280
46Neoplasm of head and neck (HP:0012288)2.34945280
47Cerebral aneurysm (HP:0004944)2.33813873
48Mesangial abnormality (HP:0001966)2.31472226
49Abnormality of the anterior chamber (HP:0000593)2.30631230
50Trismus (HP:0000211)2.29777131
51Abnormality of polysaccharide metabolism (HP:0011012)2.29345517
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29345517
53Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29345517
54Focal segmental glomerulosclerosis (HP:0000097)2.25157162
55Glucose intolerance (HP:0000833)2.23952059
56Neonatal short-limb short stature (HP:0008921)2.23608881
57Hand muscle atrophy (HP:0009130)2.21873937
58Abnormality of the distal phalanges of the toes (HP:0010182)2.15771583
59Mucopolysacchariduria (HP:0008155)2.10613055
60Urinary glycosaminoglycan excretion (HP:0003541)2.10613055
61Alacrima (HP:0000522)2.06913722
62Cerebral inclusion bodies (HP:0100314)2.02848332
63Aplasia/Hypoplasia of the fovea (HP:0008060)10.3231698
64Hypoplasia of the fovea (HP:0007750)10.3231698
65Facial cleft (HP:0002006)1.99965717
66Absent hair (HP:0002298)1.93716283
67Xanthomatosis (HP:0000991)1.91575415
68Distal upper limb amyotrophy (HP:0007149)1.90976581
69Upper limb amyotrophy (HP:0009129)1.90976581
70Premature graying of hair (HP:0002216)1.90559253
71Birth length less than 3rd percentile (HP:0003561)1.90034553
72Freckling (HP:0001480)1.89656051
73Alveolar cell carcinoma (HP:0006519)1.89092836
74Premature skin wrinkling (HP:0100678)1.88545276
75Abnormality of complement system (HP:0005339)1.86762109
76Nephritis (HP:0000123)1.86684337
77Hypoplastic labia majora (HP:0000059)1.81719715
78Global brain atrophy (HP:0002283)1.81190905
79Abnormality of the sella turcica (HP:0002679)1.78599856
80Rhabdomyosarcoma (HP:0002859)1.77605656
81Renovascular hypertension (HP:0100817)1.74420968
82Glomerulosclerosis (HP:0000096)1.73694579
83Median cleft lip (HP:0000161)1.73496334
84Neoplasm of the tracheobronchial system (HP:0100552)1.72331279
85Gastrointestinal stroma tumor (HP:0100723)1.70884437
86Absent eyelashes (HP:0000561)1.70247555
87Decreased lacrimation (HP:0000633)1.66412108
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.65797973
89Prostate neoplasm (HP:0100787)1.65512577
90Occipital encephalocele (HP:0002085)1.64953168
91Vascular calcification (HP:0004934)1.62888048
92Cutaneous melanoma (HP:0012056)1.59452880
93Abnormality of vision evoked potentials (HP:0000649)1.57765912
94Hoarse voice (HP:0001609)1.55389328
95Abnormality of the nasal septum (HP:0000419)1.54030504
96Abnormality of the labia majora (HP:0012881)1.54009125
97Vertebral compression fractures (HP:0002953)1.53153467
98Chronic hepatic failure (HP:0100626)1.49314390
99Neoplasm of striated muscle (HP:0009728)1.49025763
100Nonimmune hydrops fetalis (HP:0001790)1.48871187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.52508406
2MAP3K24.43538785
3MST1R4.12763344
4NTRK34.08515947
5PIK3CA3.97271941
6NLK3.24093021
7PDK23.19953089
8TAOK33.15366642
9CSNK1G12.49850136
10MARK32.44811789
11MET2.36122635
12WEE12.17199815
13ERBB42.09909236
14BMPR1B1.87961090
15MAPKAPK31.87219653
16PDGFRB1.85222228
17PDGFRA1.78034741
18JAK11.76479380
19GRK11.64881030
20CSNK1G31.63043815
21PRKD31.59508270
22FRK1.52589915
23KIT1.42691064
24CSNK1G21.41517055
25CSNK1A1L1.37544538
26ACVR1B1.25754913
27CDC42BPA1.16027066
28INSRR1.15973482
29LMTK21.09716650
30SGK21.06209009
31MELK1.05468375
32MATK1.04840767
33RPS6KA20.99627861
34ADRBK20.94943394
35DYRK1A0.92755652
36MAP2K20.91512821
37NEK60.87995902
38PKN10.85957510
39CAMK40.85591067
40SGK30.85413287
41ERBB20.85109321
42MAP4K20.80174903
43RET0.79539402
44SGK2230.77631330
45SGK4940.77631330
46NME10.77028827
47EPHA30.76456607
48SIK20.74451960
49FLT30.73311903
50SIK30.73297998
51MAP3K70.72905283
52CDK30.72573549
53MAP3K60.72081398
54NEK90.69858851
55GSK3A0.69547468
56AKT30.69248490
57TXK0.68354590
58MAPK70.64008751
59JAK20.60769055
60PKN20.60194115
61NTRK10.59347811
62ZAP700.59332046
63ADRBK10.58874649
64PRKD10.55343853
65AKT20.53483853
66PDPK10.53306818
67TRIM280.51669457
68ERN10.51619794
69STK390.50040604
70EIF2AK30.48789406
71PHKG10.48585295
72PHKG20.48585295
73MAP2K60.47611562
74FER0.47099131
75TIE10.46175010
76ICK0.45600149
77ABL20.45514243
78CASK0.41834057
79PTK20.41580686
80CSNK1D0.40647873
81SIK10.39455192
82LIMK10.38376538
83TGFBR10.36535386
84IGF1R0.33885351
85PDK10.33831368
86MARK20.33237652
87LATS10.31554026
88PRKCG0.31549547
89CSNK1A10.31117115
90WNK40.29965706
91DAPK20.29956081
92CHUK0.29614372
93MAP3K50.29461179
94PRKCE0.29432688
95WNK30.28476653
96CHEK20.26641057
97MAP2K10.25339083
98STK38L0.24494616
99MAPK130.22179019
100MAPK110.22165298

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.78625341
2Fatty acid biosynthesis_Homo sapiens_hsa000613.53147582
3Complement and coagulation cascades_Homo sapiens_hsa046103.28888331
4Other glycan degradation_Homo sapiens_hsa005112.79043172
5Tyrosine metabolism_Homo sapiens_hsa003502.72606278
6Lysosome_Homo sapiens_hsa041422.70652876
7Histidine metabolism_Homo sapiens_hsa003402.59970815
8Prion diseases_Homo sapiens_hsa050202.37360406
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32624032
10Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.30639296
11Collecting duct acid secretion_Homo sapiens_hsa049662.07858974
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.89744320
13Sulfur metabolism_Homo sapiens_hsa009201.88800210
14Selenocompound metabolism_Homo sapiens_hsa004501.86465166
15Arginine biosynthesis_Homo sapiens_hsa002201.77032122
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.76562445
17Phenylalanine metabolism_Homo sapiens_hsa003601.70583563
18Nitrogen metabolism_Homo sapiens_hsa009101.70305363
19ABC transporters_Homo sapiens_hsa020101.56894736
20Circadian rhythm_Homo sapiens_hsa047101.51645586
21Arginine and proline metabolism_Homo sapiens_hsa003301.50567724
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.44244228
23Melanoma_Homo sapiens_hsa052181.41408890
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39166060
25Thyroid hormone synthesis_Homo sapiens_hsa049181.36013975
26Vibrio cholerae infection_Homo sapiens_hsa051101.34192648
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33486569
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32517424
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32173024
30Starch and sucrose metabolism_Homo sapiens_hsa005001.31379536
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.28877777
32Ovarian steroidogenesis_Homo sapiens_hsa049131.26671675
33Prostate cancer_Homo sapiens_hsa052151.26457186
34Tryptophan metabolism_Homo sapiens_hsa003801.18016449
35Fat digestion and absorption_Homo sapiens_hsa049751.16456206
36Amoebiasis_Homo sapiens_hsa051461.15193754
37Protein digestion and absorption_Homo sapiens_hsa049741.14960681
38Retinol metabolism_Homo sapiens_hsa008301.10043508
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09359934
40Sphingolipid metabolism_Homo sapiens_hsa006001.07260487
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05234018
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00651669
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97238094
44Linoleic acid metabolism_Homo sapiens_hsa005910.96041768
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.95553457
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.95532166
47Chemical carcinogenesis_Homo sapiens_hsa052040.93818213
48Peroxisome_Homo sapiens_hsa041460.90333141
49Dorso-ventral axis formation_Homo sapiens_hsa043200.85505118
50Glioma_Homo sapiens_hsa052140.84383353
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83595053
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82483273
53Staphylococcus aureus infection_Homo sapiens_hsa051500.82344240
54Fatty acid degradation_Homo sapiens_hsa000710.80544906
55Insulin resistance_Homo sapiens_hsa049310.80361676
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80281403
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76718111
58N-Glycan biosynthesis_Homo sapiens_hsa005100.75572689
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75564760
60Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74885218
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74670668
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72487979
63Vitamin digestion and absorption_Homo sapiens_hsa049770.71399513
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71252931
65Sulfur relay system_Homo sapiens_hsa041220.70464399
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68197859
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.64448626
68FoxO signaling pathway_Homo sapiens_hsa040680.62928182
69ECM-receptor interaction_Homo sapiens_hsa045120.58840967
70TGF-beta signaling pathway_Homo sapiens_hsa043500.56335589
71Protein export_Homo sapiens_hsa030600.55999832
72Arachidonic acid metabolism_Homo sapiens_hsa005900.52026615
73Small cell lung cancer_Homo sapiens_hsa052220.51213412
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.50245039
75Melanogenesis_Homo sapiens_hsa049160.46199696
76Fatty acid metabolism_Homo sapiens_hsa012120.45717799
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45299445
78Mineral absorption_Homo sapiens_hsa049780.45163470
79Cocaine addiction_Homo sapiens_hsa050300.44939804
80Ether lipid metabolism_Homo sapiens_hsa005650.42953735
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42611711
82Renin-angiotensin system_Homo sapiens_hsa046140.42483962
83Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41113211
84Rheumatoid arthritis_Homo sapiens_hsa053230.40770297
85Focal adhesion_Homo sapiens_hsa045100.39988099
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38098729
87mTOR signaling pathway_Homo sapiens_hsa041500.37723452
88Lysine degradation_Homo sapiens_hsa003100.36414866
89AMPK signaling pathway_Homo sapiens_hsa041520.35079108
90beta-Alanine metabolism_Homo sapiens_hsa004100.33592562
91Metabolic pathways_Homo sapiens_hsa011000.33491467
92Estrogen signaling pathway_Homo sapiens_hsa049150.33435691
93Synaptic vesicle cycle_Homo sapiens_hsa047210.32491261
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30813219
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30517298
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29672082
97Glycerolipid metabolism_Homo sapiens_hsa005610.28986727
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.27551774
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26048804
100Ras signaling pathway_Homo sapiens_hsa040140.25395881

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