PAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.81443271
2Golgi transport vesicle coating (GO:0048200)5.81443271
3DNA deamination (GO:0045006)4.73601074
4regulation of glucose import in response to insulin stimulus (GO:2001273)4.72375326
5spliceosomal tri-snRNP complex assembly (GO:0000244)4.43443811
6mitotic chromosome condensation (GO:0007076)4.35839463
7negative regulation of fatty acid transport (GO:2000192)4.29831152
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.24216633
9negative regulation of DNA-templated transcription, elongation (GO:0032785)4.07956233
10regulation of mitotic spindle organization (GO:0060236)4.05993066
11formation of translation preinitiation complex (GO:0001731)3.87467595
12protein retention in ER lumen (GO:0006621)3.76239614
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73977013
14mitotic sister chromatid segregation (GO:0000070)3.73032265
15nuclear envelope reassembly (GO:0031468)3.63172348
16mitotic nuclear envelope reassembly (GO:0007084)3.63172348
17protein maturation by protein folding (GO:0022417)3.60241414
18skin morphogenesis (GO:0043589)3.59788369
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44648060
20regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43567786
21regulation of double-strand break repair via homologous recombination (GO:0010569)3.38819571
22ribosomal small subunit biogenesis (GO:0042274)3.37620922
23protein localization to endosome (GO:0036010)3.36616722
24pentose-phosphate shunt (GO:0006098)3.35543591
25myelin maintenance (GO:0043217)3.32449699
26sister chromatid segregation (GO:0000819)3.31347207
27positive regulation of vesicle fusion (GO:0031340)3.29517879
28regulation of chromatin binding (GO:0035561)3.28402590
29activation of Rac GTPase activity (GO:0032863)3.28233046
30peptidyl-arginine omega-N-methylation (GO:0035247)3.27656131
31spliceosomal complex assembly (GO:0000245)3.23095610
32positive regulation of cellular response to insulin stimulus (GO:1900078)3.20740705
33nucleobase-containing small molecule interconversion (GO:0015949)3.17364246
34regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16589780
35regulation of spindle organization (GO:0090224)3.13420397
36DNA strand elongation (GO:0022616)3.11938850
37negative regulation of cell size (GO:0045792)3.11219426
38DNA strand elongation involved in DNA replication (GO:0006271)3.10423978
393-UTR-mediated mRNA stabilization (GO:0070935)3.07920865
40RNA stabilization (GO:0043489)3.04924736
41mRNA stabilization (GO:0048255)3.04924736
42positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.04269502
43establishment of viral latency (GO:0019043)3.03694709
44establishment of integrated proviral latency (GO:0075713)3.03538542
45regulation of nucleobase-containing compound transport (GO:0032239)3.01645457
46negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.00915023
47positive regulation of macroautophagy (GO:0016239)3.00686409
48proline biosynthetic process (GO:0006561)2.99334189
49telomere maintenance via semi-conservative replication (GO:0032201)2.95717491
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.94634202
51DNA replication checkpoint (GO:0000076)2.94027461
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.92271213
53glucose catabolic process (GO:0006007)2.90070381
54regulation of nuclear cell cycle DNA replication (GO:0033262)2.89144684
55NADPH regeneration (GO:0006740)2.88639444
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.87443284
57telomere maintenance via recombination (GO:0000722)2.84619649
58RNA splicing, via transesterification reactions (GO:0000375)2.81848375
59mRNA splicing, via spliceosome (GO:0000398)2.80809387
60RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80809387
61DNA replication initiation (GO:0006270)2.78801494
62intracellular estrogen receptor signaling pathway (GO:0030520)2.77208665
63regulation of telomere maintenance via telomerase (GO:0032210)2.77190645
64spliceosomal snRNP assembly (GO:0000387)2.76538327
65adherens junction assembly (GO:0034333)2.76378948
66DNA unwinding involved in DNA replication (GO:0006268)2.75772626
67mitotic cytokinesis (GO:0000281)2.74323088
68positive regulation of RNA splicing (GO:0033120)2.73703598
69mitochondrial fusion (GO:0008053)2.69738938
70telomere maintenance via telomere lengthening (GO:0010833)2.69580281
71positive thymic T cell selection (GO:0045059)2.68944113
72intra-S DNA damage checkpoint (GO:0031573)2.68144812
73histone H2A acetylation (GO:0043968)2.67671142
74dosage compensation (GO:0007549)2.67239581
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.66884139
76SMAD protein complex assembly (GO:0007183)2.66284096
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65979470
78regulation of helicase activity (GO:0051095)2.65881625
79ribosome biogenesis (GO:0042254)2.65577069
80peptidyl-arginine methylation (GO:0018216)2.64610942
81peptidyl-arginine N-methylation (GO:0035246)2.64610942
82positive regulation of nuclease activity (GO:0032075)2.64149177
83mitotic recombination (GO:0006312)2.63432262
84kinetochore organization (GO:0051383)2.62584372
85kinetochore assembly (GO:0051382)2.61166159
86positive regulation of Cdc42 GTPase activity (GO:0043089)2.59132891
87chromosome condensation (GO:0030261)2.58523579
88regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.58096238
89IMP biosynthetic process (GO:0006188)2.57684811
90positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.57098932
91regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.57098932
92centriole replication (GO:0007099)2.57020916
93stress fiber assembly (GO:0043149)2.55183160
94nucleosome disassembly (GO:0006337)2.54983250
95protein-DNA complex disassembly (GO:0032986)2.54983250
96cell-substrate adherens junction assembly (GO:0007045)2.54898582
97focal adhesion assembly (GO:0048041)2.54898582
98RNA localization (GO:0006403)2.54475170
99mismatch repair (GO:0006298)2.54364745
100centriole assembly (GO:0098534)2.53511300
101RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52192553
102tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52192553
103regulation of translational fidelity (GO:0006450)2.51414627
104regulation of superoxide anion generation (GO:0032928)2.51327745
105GDP-mannose metabolic process (GO:0019673)2.50852064
106negative regulation of erythrocyte differentiation (GO:0045647)2.50581301
107inner cell mass cell proliferation (GO:0001833)2.49777822
108DNA replication-independent nucleosome organization (GO:0034724)2.48917793
109DNA replication-independent nucleosome assembly (GO:0006336)2.48917793
110antigen processing and presentation via MHC class Ib (GO:0002475)2.48637173
111negative regulation of mRNA processing (GO:0050686)2.48416533
112negative regulation of RNA splicing (GO:0033119)2.47931895
113tRNA methylation (GO:0030488)2.47478816
114endoplasmic reticulum unfolded protein response (GO:0030968)2.47200712
115* regulation of DNA-templated transcription, elongation (GO:0032784)2.46503320
116mammary gland epithelial cell differentiation (GO:0060644)2.46335976
117epithelial cell-cell adhesion (GO:0090136)2.45677681
118dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.45624998
119apoptotic process involved in morphogenesis (GO:0060561)2.45337155
120DNA geometric change (GO:0032392)2.45308094
121viral genome replication (GO:0019079)2.44705146
122cellular response to virus (GO:0098586)2.44351276
123glucose 6-phosphate metabolic process (GO:0051156)2.43591701
124positive regulation of extracellular matrix organization (GO:1903055)2.43333472
125DNA damage response, signal transduction resulting in transcription (GO:0042772)2.42588904
126regulation of RNA export from nucleus (GO:0046831)2.42479491
127DNA duplex unwinding (GO:0032508)2.42091872
128histone H3-K9 methylation (GO:0051567)2.41964738
129NIK/NF-kappaB signaling (GO:0038061)2.41550635
130positive regulation of histone H3-K4 methylation (GO:0051571)2.41196432
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.40611740
132regulation of translational termination (GO:0006449)2.40174658
133regulation of exit from mitosis (GO:0007096)2.40031938
134telomere organization (GO:0032200)2.39743817
135vesicle coating (GO:0006901)2.39685496
136telomere maintenance (GO:0000723)2.39477838
137activation of MAPKKK activity (GO:0000185)2.39069307
138histone arginine methylation (GO:0034969)2.38881418
139establishment of chromosome localization (GO:0051303)2.38795192
140ER-nucleus signaling pathway (GO:0006984)2.37511066
141* positive regulation of DNA-templated transcription, elongation (GO:0032786)2.37428834
142regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.37352735
143histone H4-K12 acetylation (GO:0043983)2.37252830
144ribosome assembly (GO:0042255)2.36858679
145mitotic metaphase plate congression (GO:0007080)2.36288695
146regulation of histone H3-K27 methylation (GO:0061085)2.36004209
147protein localization to kinetochore (GO:0034501)2.35053986
148CENP-A containing nucleosome assembly (GO:0034080)2.34593977
149transcription elongation from RNA polymerase II promoter (GO:0006368)2.32624173
150DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.32536974
151termination of RNA polymerase II transcription (GO:0006369)2.32294999
152translesion synthesis (GO:0019985)2.30975141
153nuclear pore organization (GO:0006999)2.29639287
154nuclear pore complex assembly (GO:0051292)2.29178571
155metaphase plate congression (GO:0051310)2.26839730
156positive regulation of tolerance induction (GO:0002645)2.26703324
157barbed-end actin filament capping (GO:0051016)2.25488857
158embryonic camera-type eye development (GO:0031076)2.25084144
159meiotic chromosome segregation (GO:0045132)2.24958940
160RNA splicing (GO:0008380)2.24868854
161L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.24185879
162viral mRNA export from host cell nucleus (GO:0046784)2.23625127
163protein localization to chromosome (GO:0034502)2.22945727
164regulation of tolerance induction (GO:0002643)2.22741749
165chromatin remodeling at centromere (GO:0031055)2.22615117
166positive regulation of gamma-delta T cell activation (GO:0046645)2.21918258
167GMP metabolic process (GO:0046037)2.21546440
168ATP-dependent chromatin remodeling (GO:0043044)2.21253374
169pore complex assembly (GO:0046931)2.20991785
170regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.20866892
171regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.19224199
172regulation of mitotic spindle checkpoint (GO:1903504)2.19224199
173IMP metabolic process (GO:0046040)2.19127574
174* histone H2B ubiquitination (GO:0033523)2.18557064
175negative regulation of cell cycle arrest (GO:0071157)2.17386119
176rRNA transcription (GO:0009303)2.17075272
177B cell mediated immunity (GO:0019724)2.16661705
178modulation by virus of host process (GO:0019054)2.15863764
179positive regulation of histone methylation (GO:0031062)2.15705133
180negative regulation of glycoprotein biosynthetic process (GO:0010561)2.15153382
181histone H3-K4 methylation (GO:0051568)2.14915115
182protein localization to chromosome, centromeric region (GO:0071459)2.14812718
183DNA-templated transcription, elongation (GO:0006354)2.13853328
184regulation of double-strand break repair (GO:2000779)2.11783302
185apoptotic process involved in development (GO:1902742)2.11710999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.66805356
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.50380943
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.26642659
4ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92961903
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92078320
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.88949030
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85712895
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.68151533
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.64373569
10* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55950145
11CIITA_25753668_ChIP-Seq_RAJI_Human2.51258518
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.46098464
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.34616537
14* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33762427
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30843009
16MYC_22102868_ChIP-Seq_BL_Human2.23869595
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11100322
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.09438490
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.08443145
20* XRN2_22483619_ChIP-Seq_HELA_Human2.07884031
21VDR_21846776_ChIP-Seq_THP-1_Human2.07453461
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.06761085
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05569294
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03532903
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03049549
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97421486
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97202944
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.94932778
29ZNF263_19887448_ChIP-Seq_K562_Human1.92359923
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.87706314
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87543385
32LXR_22292898_ChIP-Seq_THP-1_Human1.84796963
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.84444465
34RACK7_27058665_Chip-Seq_MCF-7_Human1.83945724
35* VDR_23849224_ChIP-Seq_CD4+_Human1.81955627
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81782089
37* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79366249
38FOXP3_21729870_ChIP-Seq_TREG_Human1.78098238
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.76560476
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74814019
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74472453
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.72625068
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.70770122
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.69805130
45SCL_19346495_ChIP-Seq_HPC-7_Human1.69216251
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66935247
47* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66503373
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.61995562
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60869710
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.59035627
51GABP_19822575_ChIP-Seq_HepG2_Human1.58775001
52CLOCK_20551151_ChIP-Seq_293T_Human1.58449710
53CREB1_15753290_ChIP-ChIP_HEK293T_Human1.57777423
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56473734
55SPI1_23547873_ChIP-Seq_NB4_Human1.53384508
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52283371
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51577959
58* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51475981
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49731082
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.49552949
61MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49467948
62* TTF2_22483619_ChIP-Seq_HELA_Human1.47129147
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46274475
64MAF_26560356_Chip-Seq_TH1_Human1.45835916
65YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45421235
66HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.45364331
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45004667
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44842205
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44532460
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44280286
71UTX_26944678_Chip-Seq_JUKART_Human1.41999370
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40837081
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39053584
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37874203
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37339589
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36448112
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36329291
78KDM5A_27292631_Chip-Seq_BREAST_Human1.35733098
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33817328
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.32532022
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31743623
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31442506
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.31232790
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31064419
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30487196
86ATF3_27146783_Chip-Seq_COLON_Human1.29784495
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28297651
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27767259
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27580255
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25396023
91MYB_26560356_Chip-Seq_TH1_Human1.24912574
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23755143
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23365472
94TFEB_21752829_ChIP-Seq_HELA_Human1.23133210
95SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22322338
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22250215
97AR_21909140_ChIP-Seq_LNCAP_Human1.20912109
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20302327
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19864109
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18210607
101P68_20966046_ChIP-Seq_HELA_Human1.17744508
102* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17539191
103* MAF_26560356_Chip-Seq_TH2_Human1.16249041
104* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15805107
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15296423
106* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15183880
107PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13876633
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13614132
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13466535
110RUNX1_22412390_ChIP-Seq_EML_Mouse1.11803733
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.11589518
112KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11530316
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11480561
114RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10365761
115DCP1A_22483619_ChIP-Seq_HELA_Human1.10192356
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09737258
117MYB_26560356_Chip-Seq_TH2_Human1.08820160
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08626532
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08415860
120ELK3_25401928_ChIP-Seq_HUVEC_Human1.08344061
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.08069462
122* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08029851
123SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07057311
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06902494
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06646888
126ESR2_21235772_ChIP-Seq_MCF-7_Human1.06172787
127VDR_24763502_ChIP-Seq_THP-1_Human1.06049480
128CREB1_26743006_Chip-Seq_LNCaP_Human1.05875989
129FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05440400
130* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04827219
131TCF7_22412390_ChIP-Seq_EML_Mouse1.04488612
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04298445
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04127123
134KDM2B_26808549_Chip-Seq_K562_Human1.03979770
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02095771
136TP53_22127205_ChIP-Seq_IMR90_Human1.01877997
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01836766
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01820782
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01724800
140STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00044095
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99629022
142KDM2B_26808549_Chip-Seq_JURKAT_Human0.99394186
143SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98894294
144TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98610122
145ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96113797
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95974590
147E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95973244
148TP63_17297297_ChIP-ChIP_HaCaT_Human0.93129254
149FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.92493258
150KDM2B_26808549_Chip-Seq_DND41_Human0.91626574
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.91280877
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.90791173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004185_abnormal_adipocyte_glucose4.45986791
2MP0002877_abnormal_melanocyte_morpholog4.16411987
3MP0003693_abnormal_embryo_hatching3.27592275
4MP0003705_abnormal_hypodermis_morpholog3.16641360
5MP0005451_abnormal_body_composition3.07056845
6MP0008058_abnormal_DNA_repair2.90751098
7MP0005623_abnormal_meninges_morphology2.85774103
8MP0008057_abnormal_DNA_replication2.73473156
9MP0003111_abnormal_nucleus_morphology2.68478710
10MP0010094_abnormal_chromosome_stability2.54612882
11MP0002102_abnormal_ear_morphology2.52205969
12MP0003763_abnormal_thymus_physiology2.48137318
13MP0008260_abnormal_autophagy2.48104662
14MP0004233_abnormal_muscle_weight2.48085570
15MP0008007_abnormal_cellular_replicative2.46109067
16MP0002396_abnormal_hematopoietic_system2.33611617
17MP0003077_abnormal_cell_cycle2.30216950
18MP0003566_abnormal_cell_adhesion2.29139866
19MP0000537_abnormal_urethra_morphology2.29020376
20MP0002132_abnormal_respiratory_system2.26622056
21MP0006292_abnormal_olfactory_placode2.10358405
22MP0001727_abnormal_embryo_implantation2.09911470
23MP0004957_abnormal_blastocyst_morpholog1.87243641
24MP0000685_abnormal_immune_system1.80040998
25MP0005666_abnormal_adipose_tissue1.79089076
26MP0002277_abnormal_respiratory_mucosa1.76676813
27MP0000678_abnormal_parathyroid_gland1.75213293
28MP0005501_abnormal_skin_physiology1.73037070
29MP0003453_abnormal_keratinocyte_physiol1.70501093
30MP0009333_abnormal_splenocyte_physiolog1.65627301
31MP0004510_myositis1.63260126
32MP0008877_abnormal_DNA_methylation1.61441952
33MP0001835_abnormal_antigen_presentation1.60306722
34MP0003191_abnormal_cellular_cholesterol1.58833758
35MP0001800_abnormal_humoral_immune1.52227835
36MP0000747_muscle_weakness1.51795585
37MP0000703_abnormal_thymus_morphology1.49808471
38MP0002398_abnormal_bone_marrow1.47865152
39MP0000490_abnormal_crypts_of1.46666974
40MP0002452_abnormal_antigen_presenting1.45753887
41MP0008932_abnormal_embryonic_tissue1.44629688
42MP0009840_abnormal_foam_cell1.44536483
43MP0003091_abnormal_cell_migration1.43043543
44MP0002405_respiratory_system_inflammati1.40993024
45MP0003828_pulmonary_edema1.40888690
46MP0009278_abnormal_bone_marrow1.39591636
47MP0002249_abnormal_larynx_morphology1.38549869
48MP0000569_abnormal_digit_pigmentation1.38318278
49MP0000350_abnormal_cell_proliferation1.36495643
50MP0001819_abnormal_immune_cell1.36375753
51MP0002723_abnormal_immune_serum1.36287378
52MP0005671_abnormal_response_to1.36182482
53MP0002420_abnormal_adaptive_immunity1.35876038
54MP0003121_genomic_imprinting1.35505399
55MP0004808_abnormal_hematopoietic_stem1.34812296
56MP0005621_abnormal_cell_physiology1.34154201
57MP0001730_embryonic_growth_arrest1.33030445
58MP0000716_abnormal_immune_system1.31615670
59MP0005375_adipose_tissue_phenotype1.30290775
60MP0002796_impaired_skin_barrier1.30007524
61MP0009053_abnormal_anal_canal1.29752690
62MP0005000_abnormal_immune_tolerance1.28920456
63MP0002722_abnormal_immune_system1.28717289
64MP0001849_ear_inflammation1.28421887
65MP0008995_early_reproductive_senescence1.27772791
66MP0005645_abnormal_hypothalamus_physiol1.27724657
67MP0003172_abnormal_lysosome_physiology1.27600170
68MP0000751_myopathy1.27181624
69MP0002148_abnormal_hypersensitivity_rea1.26520060
70MP0001293_anophthalmia1.24955748
71MP0008438_abnormal_cutaneous_collagen1.23973825
72MP0010352_gastrointestinal_tract_polyps1.23968593
73MP0000313_abnormal_cell_death1.23735179
74MP0003329_amyloid_beta_deposits1.23470370
75MP0002089_abnormal_postnatal_growth/wei1.23169358
76MP0003300_gastrointestinal_ulcer1.22340699
77MP0005076_abnormal_cell_differentiation1.19980345
78MP0001915_intracranial_hemorrhage1.19739810
79MP0003786_premature_aging1.19279094
80MP0005387_immune_system_phenotype1.19197195
81MP0001790_abnormal_immune_system1.19197195
82MP0002009_preneoplasia1.18650683
83MP0000689_abnormal_spleen_morphology1.18447306
84MP0005025_abnormal_response_to1.18171108
85MP0002429_abnormal_blood_cell1.18125328
86MP0002060_abnormal_skin_morphology1.17793135
87MP0005174_abnormal_tail_pigmentation1.16527583
88MP0004084_abnormal_cardiac_muscle1.15754117
89MP0001348_abnormal_lacrimal_gland1.13491997
90MP0000015_abnormal_ear_pigmentation1.08814406
91MP0002419_abnormal_innate_immunity1.08588031
92MP0000759_abnormal_skeletal_muscle1.07874314
93MP0005384_cellular_phenotype1.07403474
94MP0002085_abnormal_embryonic_tissue1.06893351
95MP0010234_abnormal_vibrissa_follicle1.05793906
96MP0006072_abnormal_retinal_apoptosis1.05774477
97MP0005058_abnormal_lysosome_morphology1.04696019
98MP0000467_abnormal_esophagus_morphology1.03807081
99MP0004087_abnormal_muscle_fiber1.02201114
100MP0004272_abnormal_basement_membrane1.02024556
101MP0005330_cardiomyopathy1.01718287
102MP0000003_abnormal_adipose_tissue1.00823590
103MP0000750_abnormal_muscle_regeneration0.98908340
104MP0000358_abnormal_cell_content/0.98192174
105MP0002269_muscular_atrophy0.97968975
106MP0009785_altered_susceptibility_to0.97863703
107MP0005310_abnormal_salivary_gland0.96462338
108MP0005380_embryogenesis_phenotype0.95937144
109MP0001672_abnormal_embryogenesis/_devel0.95937144
110MP0004133_heterotaxia0.95007448
111MP0002933_joint_inflammation0.94488684
112MP0001216_abnormal_epidermal_layer0.94015260
113MP0005670_abnormal_white_adipose0.93154032
114MP0000858_altered_metastatic_potential0.92974972
115MP0003315_abnormal_perineum_morphology0.92781689
116MP0002697_abnormal_eye_size0.92323158
117MP0004858_abnormal_nervous_system0.91682413
118MP0003436_decreased_susceptibility_to0.91651458
119MP0001243_abnormal_dermal_layer0.91125017
120MP0003303_peritoneal_inflammation0.90728584
121MP0010630_abnormal_cardiac_muscle0.90302557
122MP0002084_abnormal_developmental_patter0.90241817
123MP0005409_darkened_coat_color0.89606450
124MP0001697_abnormal_embryo_size0.88962738
125MP0005257_abnormal_intraocular_pressure0.87752108
126MP0002080_prenatal_lethality0.87045782
127MP0002086_abnormal_extraembryonic_tissu0.86662097
128MP0002019_abnormal_tumor_incidence0.86205757
129MP0000681_abnormal_thyroid_gland0.85924270
130MP0010307_abnormal_tumor_latency0.85651493
131MP0003221_abnormal_cardiomyocyte_apopto0.85028018
132MP0003075_altered_response_to0.84351242
133MP0006082_CNS_inflammation0.83933452
134MP0003950_abnormal_plasma_membrane0.83411048
135MP0002970_abnormal_white_adipose0.82721599
136MP0003984_embryonic_growth_retardation0.82488409
137MP0009672_abnormal_birth_weight0.82446946
138MP0002210_abnormal_sex_determination0.82271818
139MP0002896_abnormal_bone_mineralization0.82129856
140MP0000749_muscle_degeneration0.81570757
141MP0003448_altered_tumor_morphology0.81120334
142MP0005023_abnormal_wound_healing0.80668341
143MP0004947_skin_inflammation0.80106001
144MP0008961_abnormal_basal_metabolism0.79696786
145MP0005083_abnormal_biliary_tract0.78547842
146MP0002088_abnormal_embryonic_growth/wei0.78451771
147MP0003567_abnormal_fetal_cardiomyocyte0.77831373
148MP0005397_hematopoietic_system_phenotyp0.77450272
149MP0001545_abnormal_hematopoietic_system0.77450272
150MP0003656_abnormal_erythrocyte_physiolo0.76779778
151MP0001853_heart_inflammation0.76292118
152MP0003634_abnormal_glial_cell0.76036154
153MP0000762_abnormal_tongue_morphology0.76001355
154MP0006138_congestive_heart_failure0.75799003
155MP0000733_abnormal_muscle_development0.75549876
156MP0005075_abnormal_melanosome_morpholog0.75142018
157MP0001346_abnormal_lacrimal_gland0.74719130
158MP0005464_abnormal_platelet_physiology0.73711707
159MP0003942_abnormal_urinary_system0.73654462
160MP0002653_abnormal_ependyma_morphology0.72464279
161MP0000428_abnormal_craniofacial_morphol0.70635769
162MP0002127_abnormal_cardiovascular_syste0.70429260
163MP0010771_integument_phenotype0.68313132
164MP0001873_stomach_inflammation0.68307410

Predicted human phenotypes

RankGene SetZ-score
1Vertebral compression fractures (HP:0002953)3.72198453
2Neonatal hypoglycemia (HP:0001998)3.70513909
3Hyperacusis (HP:0010780)3.54186763
4Achilles tendon contracture (HP:0001771)3.48312546
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.47815520
6Broad distal phalanx of finger (HP:0009836)3.36581201
7Abnormality of the distal phalanges of the toes (HP:0010182)3.23493627
8Premature rupture of membranes (HP:0001788)3.22630340
9Distal lower limb amyotrophy (HP:0008944)3.17064283
10Abnormality of the Achilles tendon (HP:0005109)3.16245845
11Chromsome breakage (HP:0040012)3.12880415
12Protrusio acetabuli (HP:0003179)3.08081084
13Short nail (HP:0001799)3.02487359
14Progressive muscle weakness (HP:0003323)2.98626622
15Ragged-red muscle fibers (HP:0003200)2.95850484
16Muscle fiber atrophy (HP:0100295)2.87293575
17Albinism (HP:0001022)2.86692978
18Upper limb amyotrophy (HP:0009129)2.85646364
19Distal upper limb amyotrophy (HP:0007149)2.85646364
20Insomnia (HP:0100785)2.83327074
21Increased connective tissue (HP:0009025)2.79549555
22Back pain (HP:0003418)2.69791303
23Patellar aplasia (HP:0006443)2.66099682
24Difficulty climbing stairs (HP:0003551)2.64575744
25Type 2 muscle fiber atrophy (HP:0003554)2.63827299
26Septo-optic dysplasia (HP:0100842)2.63766999
27Ulnar bowing (HP:0003031)2.62335641
28Hand muscle atrophy (HP:0009130)2.58034855
29Abnormal gallbladder physiology (HP:0012438)2.56546178
30Cholecystitis (HP:0001082)2.56546178
31Reduced subcutaneous adipose tissue (HP:0003758)2.56309005
32Trismus (HP:0000211)2.55520157
33Distal lower limb muscle weakness (HP:0009053)2.48918698
34Aplastic anemia (HP:0001915)2.48905354
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.46995714
36Degeneration of anterior horn cells (HP:0002398)2.46388642
37Abnormality of the anterior horn cell (HP:0006802)2.46388642
38Broad face (HP:0000283)2.43665998
39IgM deficiency (HP:0002850)2.43085147
40Severe visual impairment (HP:0001141)2.42693414
41Absent radius (HP:0003974)2.42564023
42Myopathic facies (HP:0002058)2.38676045
43Pelvic girdle muscle weakness (HP:0003749)2.37895502
44Recurrent fungal infections (HP:0002841)2.36905220
45Abnormal number of incisors (HP:0011064)2.36364962
46Lower limb amyotrophy (HP:0007210)2.36171775
47Aplasia/Hypoplasia of the patella (HP:0006498)2.36030958
48Recurrent abscess formation (HP:0002722)2.34848648
49Abnormality of the intervertebral disk (HP:0005108)2.33928744
50Long eyelashes (HP:0000527)2.32226648
51Prominent nose (HP:0000448)2.31395384
52Abnormality of DNA repair (HP:0003254)2.30249965
53Granulocytopenia (HP:0001913)2.29629030
54Mesangial abnormality (HP:0001966)2.29563317
55Long palpebral fissure (HP:0000637)2.29006594
56Mediastinal lymphadenopathy (HP:0100721)2.28212831
57Eosinophilia (HP:0001880)2.28153718
58Centrally nucleated skeletal muscle fibers (HP:0003687)2.27751738
59Abnormality of homocysteine metabolism (HP:0010919)2.25347194
60Homocystinuria (HP:0002156)2.25347194
61Acanthosis nigricans (HP:0000956)2.25165519
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.22649649
63Pendular nystagmus (HP:0012043)2.21001864
64Aplasia involving forearm bones (HP:0009822)2.18257311
65Absent forearm bone (HP:0003953)2.18257311
66Bone marrow hypocellularity (HP:0005528)2.17782640
67Duplicated collecting system (HP:0000081)2.17733399
68Elevated erythrocyte sedimentation rate (HP:0003565)2.17589170
69Spinal rigidity (HP:0003306)2.17529281
70Ependymoma (HP:0002888)2.17483417
71Limb-girdle muscle atrophy (HP:0003797)2.16792116
72Biconcave vertebral bodies (HP:0004586)2.16786231
73Hyperparathyroidism (HP:0000843)2.14305558
74Cerebral hypomyelination (HP:0006808)2.14214615
75Fragile skin (HP:0001030)2.12833624
76Eczematoid dermatitis (HP:0000976)2.12798466
77Insidious onset (HP:0003587)2.12405063
78Termporal pattern (HP:0011008)2.12405063
79Abnormality of dentin (HP:0010299)2.10753462
80Deviation of the thumb (HP:0009603)2.10381276
81Abnormality of the preputium (HP:0100587)2.09322763
82Meckel diverticulum (HP:0002245)2.08695909
83Ventricular tachycardia (HP:0004756)2.08341340
84Proximal placement of thumb (HP:0009623)2.07718090
85Recurrent cutaneous fungal infections (HP:0011370)2.07167013
86Chronic mucocutaneous candidiasis (HP:0002728)2.07167013
87Aplasia/Hypoplasia of the earlobes (HP:0009906)2.06984415
88Carpal bone hypoplasia (HP:0001498)2.04739966
89Cerebral inclusion bodies (HP:0100314)2.04167202
90Shoulder girdle muscle weakness (HP:0003547)2.03746919
91Supernumerary spleens (HP:0009799)1.98749432
92Late onset (HP:0003584)1.97093342
93Rough bone trabeculation (HP:0100670)1.96563399
94Obstructive lung disease (HP:0006536)1.95858003
95Chronic obstructive pulmonary disease (HP:0006510)1.95858003
96Ectopic kidney (HP:0000086)1.95801204
97Atelectasis (HP:0100750)1.95678033
98Spastic diplegia (HP:0001264)1.94618727
99Abnormality of the ileum (HP:0001549)1.94452145
100Duplication of thumb phalanx (HP:0009942)1.93990105
101Abnormality of the salivary glands (HP:0010286)1.93704134
102Selective tooth agenesis (HP:0001592)1.92269078
103Abnormal rod and cone electroretinograms (HP:0008323)1.91755780
104Abnormality of the renal collecting system (HP:0004742)1.91422403
105Impulsivity (HP:0100710)1.90811429
106Hammertoe (HP:0001765)1.90725717
107Mitral regurgitation (HP:0001653)1.90322800
108Atrophic scars (HP:0001075)1.90199415
109Abnormality of cells of the lymphoid lineage (HP:0012140)1.89656953
110Leukocytosis (HP:0001974)1.89248009
111Abnormality of the umbilical cord (HP:0010881)1.89068070
112IgG deficiency (HP:0004315)1.88617955
113Partial duplication of thumb phalanx (HP:0009944)1.87236547
114Unilateral renal agenesis (HP:0000122)1.86722190
115Anomalous pulmonary venous return (HP:0010772)1.85965195
116Pointed chin (HP:0000307)1.84732519
117Lymphoma (HP:0002665)1.84477960
118Spinal cord compression (HP:0002176)1.84395848
119Abnormality of eosinophils (HP:0001879)1.84251670
120Abnormality of chromosome stability (HP:0003220)1.84079554
121Growth hormone excess (HP:0000845)1.83258841
122Osteolytic defects of the hand bones (HP:0009699)1.82943341
123Osteolytic defects of the phalanges of the hand (HP:0009771)1.82943341
124Weak cry (HP:0001612)1.82928518
125Multiple lipomas (HP:0001012)1.82397519
126Abnormality of the fingertips (HP:0001211)1.81398380
127Myositis (HP:0100614)1.81234359
128Patellar dislocation (HP:0002999)1.80070345
129Hypoproteinemia (HP:0003075)1.79843208
130Stomatitis (HP:0010280)1.78795895
131Abnormality of the hip-girdle musculature (HP:0001445)1.78626005
132Abnormality of the musculature of the pelvis (HP:0001469)1.78626005
133Insulin resistance (HP:0000855)1.78622018
134Syringomyelia (HP:0003396)1.78454636
135Spinal cord lesions (HP:0100561)1.78454636
136Panhypogammaglobulinemia (HP:0003139)1.78381196
137Triphalangeal thumb (HP:0001199)1.77677084
138Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77491859
139Abnormal protein N-linked glycosylation (HP:0012347)1.77491859
140Abnormal protein glycosylation (HP:0012346)1.77491859
141Abnormal glycosylation (HP:0012345)1.77491859
142Microvesicular hepatic steatosis (HP:0001414)1.76777148
143Asplenia (HP:0001746)1.76557522
144Congenital stationary night blindness (HP:0007642)1.75910593
145Leukopenia (HP:0001882)1.75643195
146Type I transferrin isoform profile (HP:0003642)1.75535717
147Dislocated radial head (HP:0003083)1.75457862
148Severe combined immunodeficiency (HP:0004430)1.75393382
149Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75179414
150Increased IgM level (HP:0003496)1.75134605
151Tracheoesophageal fistula (HP:0002575)1.74876048
152Recurrent viral infections (HP:0004429)1.74725778
153Flattened epiphyses (HP:0003071)1.73719703
154Wormian bones (HP:0002645)1.73632256
155Cholelithiasis (HP:0001081)1.73601663
156Progressive external ophthalmoplegia (HP:0000590)1.72862418
157Porencephaly (HP:0002132)1.72264921
158Depressed nasal tip (HP:0000437)1.71761920
159Abnormality of the phalanges of the hallux (HP:0010057)1.71320006
160Petechiae (HP:0000967)1.71318455
161Entropion (HP:0000621)1.70901318
162Abnormal trabecular bone morphology (HP:0100671)1.70801482
163Pancytopenia (HP:0001876)1.70705754
164Clubbing of toes (HP:0100760)1.70658513
165Premature graying of hair (HP:0002216)1.70352123
166Abnormality of the lower motor neuron (HP:0002366)1.69198183
167Microretrognathia (HP:0000308)1.68930650
168Nuclear cataract (HP:0100018)1.68865539
169Lymphopenia (HP:0001888)1.68673099
170Abnormality of the radial head (HP:0003995)1.67852474
171Decreased motor nerve conduction velocity (HP:0003431)1.67391587
172Apathy (HP:0000741)1.67384154
173Recurrent bacterial skin infections (HP:0005406)1.66928593
174Acute lymphatic leukemia (HP:0006721)1.66692505
175Recurrent pneumonia (HP:0006532)1.66562734
176Orthostatic hypotension (HP:0001278)1.66119585
177Hemorrhage of the eye (HP:0011885)1.66111921
178Myelodysplasia (HP:0002863)1.66059930
179Genu recurvatum (HP:0002816)1.65655660
180Scapular winging (HP:0003691)1.65516580
181Hypertensive crisis (HP:0100735)1.65406183
182Flat acetabular roof (HP:0003180)1.65403281
183Sparse lateral eyebrow (HP:0005338)1.65332272
184Fatigue (HP:0012378)1.64698314
185Foot dorsiflexor weakness (HP:0009027)1.64568428
186Arterial tortuosity (HP:0005116)1.64205988
187Axonal loss (HP:0003447)1.63739775
188Abnormality of glycolysis (HP:0004366)1.63506174
189Generalized amyotrophy (HP:0003700)1.63287147
190Progressive hearing impairment (HP:0001730)1.63246910
191Reticulocytosis (HP:0001923)1.62577726
192Abnormality of the calcaneus (HP:0008364)1.61947717
193Asymmetry of the thorax (HP:0001555)1.60817646
194Obstructive sleep apnea (HP:0002870)1.60786810
195Male infertility (HP:0003251)1.60492320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB39.14553391
2CDK123.56584457
3PLK43.10985644
4SIK32.93767191
5BRD42.57595818
6NME22.48209429
7CDC72.47792611
8SMG12.45998123
9MAP4K12.36694332
10BUB12.28800192
11TESK12.27180718
12NEK22.21322575
13BLK2.20181082
14BCR2.01219101
15IRAK41.95114461
16SRPK11.94878609
17ILK1.84599019
18STK161.84420013
19PRPF4B1.81550457
20TESK21.77085107
21WEE11.76550933
22DYRK31.73480725
23STK101.71628928
24MAPK151.68568168
25CDK91.61362479
26SIK11.60741739
27ERBB31.56298917
28CDK71.49652454
29IKBKB1.49368962
30EEF2K1.46750448
31ATR1.45551089
32ZAK1.45370977
33TGFBR21.43514903
34CHUK1.36025584
35IKBKE1.30910400
36BTK1.27288244
37TXK1.25252375
38ZAP701.24379762
39VRK11.23695379
40ARAF1.22972803
41TAOK21.22883367
42MAP3K31.20419898
43EIF2AK31.15679990
44CSF1R1.14814175
45RPS6KA41.13763439
46TBK11.13530823
47ITK1.11942441
48CHEK21.11319511
49LIMK11.10829508
50CAMK1D1.10206252
51CDK41.09178831
52EIF2AK21.08858622
53IRAK11.08154097
54AKT21.05594769
55AURKB1.04731010
56PIK3CG1.04296150
57VRK21.03585279
58MARK31.02384213
59MAP2K21.01553661
60KIT1.01314855
61KDR1.00607556
62TEC0.98418450
63LATS20.97919966
64STK40.95592513
65MAP3K140.94654021
66CHEK10.94437871
67PASK0.93827035
68PLK10.93273364
69NTRK20.92000595
70FGFR40.91736681
71PDGFRA0.91614301
72TTK0.90890821
73SCYL20.90000614
74MOS0.88212002
75TSSK60.86650068
76LRRK20.86606199
77RIPK10.84799423
78PKN20.84572205
79ACVR1B0.84549565
80PBK0.83314657
81ICK0.82253168
82CLK10.81390956
83PTK20.81360850
84PAK60.81233875
85IRAK30.81142922
86CDK80.79092823
87NEK10.79061060
88CAMK1G0.78910116
89MAP3K80.78654495
90IRAK20.76378931
91MST1R0.75676372
92RPS6KA50.74502059
93SIK20.73826092
94PIM20.73134425
95EPHB20.72881598
96BRAF0.72323626
97JAK30.70874153
98MAP3K100.69545328
99AURKA0.68782485
100EPHA20.67877644
101PIM10.66435158
102PDPK10.66324817
103DYRK20.65928171
104NTRK10.65191590
105BRSK10.65009090
106MTOR0.63385308
107KSR10.61153017
108CDK20.60270234
109MAP3K130.59713690
110RPS6KB20.59404064
111TTN0.57140478
112EIF2AK10.56534035
113PAK20.55061490
114OBSCN0.54919332
115PRKD30.54572906
116MAPKAPK20.54567563
117CDK60.54557213
118MAP3K20.53348483
119CDK11A0.53322286
120MAP2K30.53184069
121TYK20.52138259
122TLK10.51831647
123KSR20.51555172
124ATM0.49207313
125NLK0.49185834
126CDK150.48878850
127ERN10.48818182
128ERBB40.48546056
129PAK10.48242574
130PTK60.48050654
131MAP3K110.48043227
132LMTK20.47937808
133CDK140.47872215
134PAK40.47366063
135LYN0.46551714
136HCK0.45906873
137CDK180.45053324
138LCK0.42432804
139PRKCI0.41454314
140FLT30.41177738
141ALK0.41102586
142ROCK20.40399748
143CDK10.39522596
144EPHB10.38872481
145TAOK10.38230820
146PRKD20.38116618
147TGFBR10.37510798
148BRSK20.37156588
149DYRK1B0.37088912
150AKT10.37084118
151SYK0.36773898
152MAPK110.36248632
153RPS6KA20.31591063
154MAP3K10.29727394

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.20978926
2Spliceosome_Homo sapiens_hsa030403.16267138
3Base excision repair_Homo sapiens_hsa034102.48713162
4RNA polymerase_Homo sapiens_hsa030202.46506847
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43289893
6Mismatch repair_Homo sapiens_hsa034302.41194340
7Non-homologous end-joining_Homo sapiens_hsa034502.14799375
8Basal transcription factors_Homo sapiens_hsa030222.12818049
9Homologous recombination_Homo sapiens_hsa034402.10488627
10Proteasome_Homo sapiens_hsa030502.02351200
11Cell cycle_Homo sapiens_hsa041101.96227167
12RNA transport_Homo sapiens_hsa030131.91413305
13Central carbon metabolism in cancer_Homo sapiens_hsa052301.87385039
14Nucleotide excision repair_Homo sapiens_hsa034201.83298275
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77128386
16Caffeine metabolism_Homo sapiens_hsa002321.77041811
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.76816092
18Fanconi anemia pathway_Homo sapiens_hsa034601.74332852
19Primary immunodeficiency_Homo sapiens_hsa053401.73113131
20Notch signaling pathway_Homo sapiens_hsa043301.70484498
21Herpes simplex infection_Homo sapiens_hsa051681.69224289
22Non-small cell lung cancer_Homo sapiens_hsa052231.69136069
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.66963901
24Pyrimidine metabolism_Homo sapiens_hsa002401.65837801
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62782675
26Sulfur relay system_Homo sapiens_hsa041221.58296651
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.57633565
28Biosynthesis of amino acids_Homo sapiens_hsa012301.52393983
29Epstein-Barr virus infection_Homo sapiens_hsa051691.50147025
30mRNA surveillance pathway_Homo sapiens_hsa030151.48279979
31Bladder cancer_Homo sapiens_hsa052191.47900393
32VEGF signaling pathway_Homo sapiens_hsa043701.46820810
33Renal cell carcinoma_Homo sapiens_hsa052111.46517180
34RNA degradation_Homo sapiens_hsa030181.45708209
35Endometrial cancer_Homo sapiens_hsa052131.44141535
36p53 signaling pathway_Homo sapiens_hsa041151.41392990
37Antigen processing and presentation_Homo sapiens_hsa046121.40593668
38Measles_Homo sapiens_hsa051621.33178055
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32018995
40Prion diseases_Homo sapiens_hsa050201.31216344
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30525942
42mTOR signaling pathway_Homo sapiens_hsa041501.26113342
43Leishmaniasis_Homo sapiens_hsa051401.24818243
44One carbon pool by folate_Homo sapiens_hsa006701.24537683
45Carbon metabolism_Homo sapiens_hsa012001.17272728
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16552331
47ErbB signaling pathway_Homo sapiens_hsa040121.15445703
48Thyroid cancer_Homo sapiens_hsa052161.15038850
49HTLV-I infection_Homo sapiens_hsa051661.14625977
50Glioma_Homo sapiens_hsa052141.14216129
51Purine metabolism_Homo sapiens_hsa002301.13003669
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11020029
53Apoptosis_Homo sapiens_hsa042101.10506507
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10433364
55Insulin signaling pathway_Homo sapiens_hsa049101.09409960
56Viral carcinogenesis_Homo sapiens_hsa052031.09264750
57Graft-versus-host disease_Homo sapiens_hsa053321.08166609
58Vibrio cholerae infection_Homo sapiens_hsa051101.08120153
59Glycosaminoglycan degradation_Homo sapiens_hsa005311.05433146
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04516640
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.02806375
62Endocytosis_Homo sapiens_hsa041441.02393375
63AMPK signaling pathway_Homo sapiens_hsa041521.01983082
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00764454
65Prostate cancer_Homo sapiens_hsa052150.99933177
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.99861584
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98591124
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97392985
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96184668
70Other glycan degradation_Homo sapiens_hsa005110.93591995
71T cell receptor signaling pathway_Homo sapiens_hsa046600.93085315
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93060166
73Galactose metabolism_Homo sapiens_hsa000520.92119142
74Allograft rejection_Homo sapiens_hsa053300.91771190
75Small cell lung cancer_Homo sapiens_hsa052220.91252803
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90487822
77Proteoglycans in cancer_Homo sapiens_hsa052050.90485882
78Ribosome_Homo sapiens_hsa030100.89776595
79B cell receptor signaling pathway_Homo sapiens_hsa046620.89297305
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87673117
81Hematopoietic cell lineage_Homo sapiens_hsa046400.87361315
82Osteoclast differentiation_Homo sapiens_hsa043800.86438073
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85775443
84Hepatitis C_Homo sapiens_hsa051600.83977858
85Viral myocarditis_Homo sapiens_hsa054160.83883103
86Shigellosis_Homo sapiens_hsa051310.83054683
87Focal adhesion_Homo sapiens_hsa045100.82972380
88TNF signaling pathway_Homo sapiens_hsa046680.82965769
89Chronic myeloid leukemia_Homo sapiens_hsa052200.82516865
90MicroRNAs in cancer_Homo sapiens_hsa052060.82388785
91Hepatitis B_Homo sapiens_hsa051610.82084958
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81945059
93Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81654026
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.81480510
95Legionellosis_Homo sapiens_hsa051340.80258140
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79157925
97Autoimmune thyroid disease_Homo sapiens_hsa053200.79080982
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74960149
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73866322
100Influenza A_Homo sapiens_hsa051640.73665254
101Estrogen signaling pathway_Homo sapiens_hsa049150.72840405
102Phenylalanine metabolism_Homo sapiens_hsa003600.68999385
103Basal cell carcinoma_Homo sapiens_hsa052170.68198882
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.67544819
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66781158
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.66651762
107Acute myeloid leukemia_Homo sapiens_hsa052210.65875419
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65732348
109Tight junction_Homo sapiens_hsa045300.60987189
110Lysine degradation_Homo sapiens_hsa003100.60179918
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59352065
112Pathways in cancer_Homo sapiens_hsa052000.59257133
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58161235
114Choline metabolism in cancer_Homo sapiens_hsa052310.57088468
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56804895
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56490143
117Systemic lupus erythematosus_Homo sapiens_hsa053220.56005403
118Prolactin signaling pathway_Homo sapiens_hsa049170.55599224
119Fatty acid elongation_Homo sapiens_hsa000620.55516962
120Lysosome_Homo sapiens_hsa041420.55486231
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52251159
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51261000
123Folate biosynthesis_Homo sapiens_hsa007900.50959779
124Chemokine signaling pathway_Homo sapiens_hsa040620.50830393
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49767767
126Pentose phosphate pathway_Homo sapiens_hsa000300.48973857
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48459990
128Pertussis_Homo sapiens_hsa051330.48450042
129Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47355073
130Malaria_Homo sapiens_hsa051440.42494890
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42446703
132Colorectal cancer_Homo sapiens_hsa052100.42309302
133Adherens junction_Homo sapiens_hsa045200.41577099
134Salmonella infection_Homo sapiens_hsa051320.41427830
135Phototransduction_Homo sapiens_hsa047440.40529894
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40370869
137Toxoplasmosis_Homo sapiens_hsa051450.40321664
138Arachidonic acid metabolism_Homo sapiens_hsa005900.39535909
139Hippo signaling pathway_Homo sapiens_hsa043900.37669343
140N-Glycan biosynthesis_Homo sapiens_hsa005100.36621260
141Asthma_Homo sapiens_hsa053100.36512766
142HIF-1 signaling pathway_Homo sapiens_hsa040660.35760090
143Fructose and mannose metabolism_Homo sapiens_hsa000510.35555337
144Pancreatic cancer_Homo sapiens_hsa052120.35419084
145Type I diabetes mellitus_Homo sapiens_hsa049400.34960029
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.33018362

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