PAFAH1B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.94187145
2DNA double-strand break processing (GO:0000729)4.87823925
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45038826
4synaptic vesicle exocytosis (GO:0016079)4.43488239
5regulation of synaptic vesicle exocytosis (GO:2000300)4.41006905
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.37990532
7layer formation in cerebral cortex (GO:0021819)4.29358041
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.11899223
9negative regulation of translation, ncRNA-mediated (GO:0040033)4.11899223
10regulation of translation, ncRNA-mediated (GO:0045974)4.11899223
11neuron cell-cell adhesion (GO:0007158)4.04842201
12negative regulation of DNA-dependent DNA replication (GO:2000104)4.04834423
13attachment of spindle microtubules to kinetochore (GO:0008608)4.02297487
14glutamate secretion (GO:0014047)3.85785878
15neuron recognition (GO:0008038)3.79112730
16protein localization to synapse (GO:0035418)3.77748791
17axonal fasciculation (GO:0007413)3.76082923
18locomotory exploration behavior (GO:0035641)3.73775204
19dendritic spine morphogenesis (GO:0060997)3.62933397
20regulation of synaptic vesicle transport (GO:1902803)3.61704703
21dendrite morphogenesis (GO:0048813)3.60919267
22water-soluble vitamin biosynthetic process (GO:0042364)3.55437134
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51168554
24proteasome assembly (GO:0043248)3.50174774
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48343002
26vocalization behavior (GO:0071625)3.45520950
27cell migration in hindbrain (GO:0021535)3.45181510
28cullin deneddylation (GO:0010388)3.42730864
29mitotic metaphase plate congression (GO:0007080)3.42130607
30lactate metabolic process (GO:0006089)3.39763712
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.39196803
32negative regulation of microtubule polymerization (GO:0031115)3.37914623
33exploration behavior (GO:0035640)3.30196395
34DNA catabolic process, exonucleolytic (GO:0000738)3.29726594
35metaphase plate congression (GO:0051310)3.27843572
36neuronal action potential propagation (GO:0019227)3.25720538
37regulation of neuronal synaptic plasticity (GO:0048168)3.24552594
38regulation of synapse structural plasticity (GO:0051823)3.24203709
39neurotransmitter secretion (GO:0007269)3.19597034
40regulation of glutamate receptor signaling pathway (GO:1900449)3.19313277
41chromatin remodeling at centromere (GO:0031055)3.17131181
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16345882
43organelle transport along microtubule (GO:0072384)3.14436652
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.12724847
45response to pheromone (GO:0019236)3.11481856
46protein K6-linked ubiquitination (GO:0085020)3.10539016
47vesicle transport along microtubule (GO:0047496)3.10399468
48replication fork processing (GO:0031297)3.08979023
49protein deneddylation (GO:0000338)3.07164575
50somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.04239936
51isotype switching (GO:0045190)3.04239936
52somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.04239936
53keratinocyte development (GO:0003334)3.04000078
54regulation of DNA endoreduplication (GO:0032875)3.00187973
55histone exchange (GO:0043486)2.99691085
56ionotropic glutamate receptor signaling pathway (GO:0035235)2.98956210
57synapsis (GO:0007129)2.98044555
58cerebral cortex radially oriented cell migration (GO:0021799)2.96308475
59CENP-A containing nucleosome assembly (GO:0034080)2.96019939
60establishment of nucleus localization (GO:0040023)2.95052237
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.93597400
62regulation of mitotic spindle checkpoint (GO:1903504)2.92376891
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.92376891
64central nervous system projection neuron axonogenesis (GO:0021952)2.92142529
65negative regulation of neurotransmitter transport (GO:0051589)2.90635966
66regulation of dendritic spine morphogenesis (GO:0061001)2.90462067
67synaptic transmission, glutamatergic (GO:0035249)2.90198241
68female gonad development (GO:0008585)2.89479762
69regulation of nuclear cell cycle DNA replication (GO:0033262)2.89406622
70histone H2A acetylation (GO:0043968)2.89281058
71neuron-neuron synaptic transmission (GO:0007270)2.88609450
72establishment of mitochondrion localization (GO:0051654)2.88606747
73respiratory chain complex IV assembly (GO:0008535)2.88576385
74regulation of vesicle fusion (GO:0031338)2.86735387
75postsynaptic membrane organization (GO:0001941)2.86637681
76positive regulation of protein autophosphorylation (GO:0031954)2.86632644
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86331110
78clathrin coat assembly (GO:0048268)2.85929805
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85806609
80axon cargo transport (GO:0008088)2.83536199
81innervation (GO:0060384)2.83152114
82synaptic vesicle endocytosis (GO:0048488)2.82319341
83axon ensheathment in central nervous system (GO:0032291)2.81438038
84central nervous system myelination (GO:0022010)2.81438038
85mating behavior (GO:0007617)2.80704781
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80512489
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.80337842
88somatic hypermutation of immunoglobulin genes (GO:0016446)2.80337842
89nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77038431
90activation of protein kinase A activity (GO:0034199)2.76843077
91glutamate receptor signaling pathway (GO:0007215)2.76571764
92nuclear pore organization (GO:0006999)2.75858430
93microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.75078006
94transmission of nerve impulse (GO:0019226)2.74660353
95regulation of neurotransmitter secretion (GO:0046928)2.73339781
96double-strand break repair via nonhomologous end joining (GO:0006303)2.72607854
97non-recombinational repair (GO:0000726)2.72607854
98positive regulation of synaptic transmission, GABAergic (GO:0032230)2.72443757
99presynaptic membrane assembly (GO:0097105)2.72188544
100negative regulation of neurotransmitter secretion (GO:0046929)2.71884334
101dendrite development (GO:0016358)2.70337662
102axon extension (GO:0048675)2.70232324
103cerebellar Purkinje cell differentiation (GO:0021702)2.69911002
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.69268637
105negative regulation of axonogenesis (GO:0050771)2.69220636
106proline transport (GO:0015824)2.68648686
107response to X-ray (GO:0010165)2.66665267
108regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66646623
109DNA replication checkpoint (GO:0000076)2.65914971
110positive regulation of synapse assembly (GO:0051965)2.65737971
111synapse assembly (GO:0007416)2.64306593
112negative regulation of DNA recombination (GO:0045910)2.64144053
113protein neddylation (GO:0045116)2.63764494
114auditory behavior (GO:0031223)2.63700916
115presynaptic membrane organization (GO:0097090)2.63617245
116cerebellar granule cell differentiation (GO:0021707)2.63365628
117neuromuscular process controlling balance (GO:0050885)2.63069957
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61021397
119peptidyl-cysteine modification (GO:0018198)2.60782403
120establishment of integrated proviral latency (GO:0075713)2.60180499
121establishment of vesicle localization (GO:0051650)2.59974917
122regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.59142422
123regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.59127018
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.59088918
125synapse organization (GO:0050808)2.58750913
126dendritic spine organization (GO:0097061)2.58553069
127neurotransmitter transport (GO:0006836)2.58440610
128pyrimidine nucleobase catabolic process (GO:0006208)2.56857225
129recombinational repair (GO:0000725)2.56387007
130negative regulation of axon extension (GO:0030517)2.56299224
131apical protein localization (GO:0045176)2.56180028
132spindle checkpoint (GO:0031577)2.55954102
133telomere maintenance via telomerase (GO:0007004)2.55786379
134establishment of synaptic vesicle localization (GO:0097480)2.55576541
135synaptic vesicle transport (GO:0048489)2.55576541
136resolution of meiotic recombination intermediates (GO:0000712)2.54599418
137double-strand break repair via homologous recombination (GO:0000724)2.54467268
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54229010
139long-term synaptic potentiation (GO:0060291)2.52928953
140regulation of neurotransmitter transport (GO:0051588)2.52809758
141positive regulation of dendritic spine morphogenesis (GO:0061003)2.52632640
142kidney morphogenesis (GO:0060993)2.52436396
143response to auditory stimulus (GO:0010996)2.52146863
144positive regulation of membrane potential (GO:0045838)2.52051533
145regulation of dendrite morphogenesis (GO:0048814)2.51085620
146postreplication repair (GO:0006301)2.50728150
147mechanosensory behavior (GO:0007638)2.50105618
148neuronal ion channel clustering (GO:0045161)2.49960946
149regulation of excitatory postsynaptic membrane potential (GO:0060079)2.49694729
150prenylation (GO:0097354)2.49646917
151protein prenylation (GO:0018342)2.49646917
152DNA deamination (GO:0045006)2.49509312
153regulation of helicase activity (GO:0051095)2.48903918
154protein K11-linked deubiquitination (GO:0035871)2.48251609
155hippocampus development (GO:0021766)2.47979997
156regulation of meiosis I (GO:0060631)2.47824584
157regulation of synaptic plasticity (GO:0048167)2.47735356
158long-term memory (GO:0007616)2.47583989
159calcium ion-dependent exocytosis (GO:0017156)2.47134354
160positive regulation of synapse maturation (GO:0090129)2.46593418
161cellular potassium ion homeostasis (GO:0030007)2.46283482
162mitotic sister chromatid cohesion (GO:0007064)2.45717472
163central nervous system neuron axonogenesis (GO:0021955)2.45631152
164regulation of axon extension (GO:0030516)2.44922329
165neuron projection extension (GO:1990138)2.44338247
166branched-chain amino acid catabolic process (GO:0009083)2.42363665
167negative regulation of telomere maintenance (GO:0032205)2.42316559
168regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.42269323
169regulation of acyl-CoA biosynthetic process (GO:0050812)2.42206865
170mitotic spindle checkpoint (GO:0071174)2.42124443
171regulation of centriole replication (GO:0046599)2.42072066
172platelet dense granule organization (GO:0060155)2.41811640
173cytochrome complex assembly (GO:0017004)2.41801572
174establishment of chromosome localization (GO:0051303)2.41604993
175maturation of 5.8S rRNA (GO:0000460)2.40478990
176somatic recombination of immunoglobulin gene segments (GO:0016447)2.39725328
177regulation of glucokinase activity (GO:0033131)2.39713624
178regulation of hexokinase activity (GO:1903299)2.39713624
179histone mRNA metabolic process (GO:0008334)2.37916480
180DNA replication-dependent nucleosome assembly (GO:0006335)2.36595679
181DNA replication-dependent nucleosome organization (GO:0034723)2.36595679
182regulation of telomere maintenance (GO:0032204)2.35024440
183positive regulation of glycoprotein biosynthetic process (GO:0010560)2.35014522
184limb bud formation (GO:0060174)2.34897928
185anterior/posterior axis specification, embryo (GO:0008595)2.34819962
186intraciliary transport (GO:0042073)2.34381344
187atrial cardiac muscle cell action potential (GO:0086014)2.34317527
188DNA ligation (GO:0006266)2.33567805
189microtubule anchoring (GO:0034453)2.33227945
190regulation of sulfur metabolic process (GO:0042762)2.32711483
191negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.32222643
192lysine catabolic process (GO:0006554)2.30832738
193lysine metabolic process (GO:0006553)2.30832738
194somatic diversification of immunoglobulins (GO:0016445)2.29936599
195regulation of cofactor metabolic process (GO:0051193)2.28992980
196regulation of coenzyme metabolic process (GO:0051196)2.28992980
197protein complex biogenesis (GO:0070271)2.28599817

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.18434542
2GBX2_23144817_ChIP-Seq_PC3_Human3.27977854
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06728694
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82222424
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80767412
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73112145
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.64478352
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49883092
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49883092
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.46343510
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.44580987
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38291026
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38200728
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36167206
15VDR_22108803_ChIP-Seq_LS180_Human2.34241191
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32632175
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.30055197
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.29992958
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.27379086
20ELK1_19687146_ChIP-ChIP_HELA_Human2.26683736
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24355111
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.19548360
23REST_21632747_ChIP-Seq_MESCs_Mouse2.16889357
24IGF1R_20145208_ChIP-Seq_DFB_Human2.14359321
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13722382
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13414545
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12765774
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12608322
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.10831270
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09129011
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04472439
32ZNF274_21170338_ChIP-Seq_K562_Hela2.02358703
33CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01293332
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99547998
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.97828378
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94481471
37RARB_27405468_Chip-Seq_BRAIN_Mouse1.87223791
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84518048
39AR_21572438_ChIP-Seq_LNCaP_Human1.83632797
40TAF15_26573619_Chip-Seq_HEK293_Human1.82669422
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79274984
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.78836616
43* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77791774
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75551271
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75209659
46E2F7_22180533_ChIP-Seq_HELA_Human1.75007973
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.73894715
48* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73767664
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72634594
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72088906
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70434471
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65112196
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64310646
54P300_19829295_ChIP-Seq_ESCs_Human1.63049867
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62659893
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62424503
57RNF2_27304074_Chip-Seq_NSC_Mouse1.61097660
58DROSHA_22980978_ChIP-Seq_HELA_Human1.60718973
59SMAD4_21799915_ChIP-Seq_A2780_Human1.58529668
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55449545
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54060094
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51620328
63FUS_26573619_Chip-Seq_HEK293_Human1.51210776
64MYC_18940864_ChIP-ChIP_HL60_Human1.51160124
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48720760
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45022110
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43281005
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42365264
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42346450
70BCAT_22108803_ChIP-Seq_LS180_Human1.42082824
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41999164
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.40992608
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.40498606
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40390648
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34296550
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33669859
77PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33599624
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.32742522
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32567993
80SOX2_21211035_ChIP-Seq_LN229_Gbm1.31548675
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31101792
82VDR_23849224_ChIP-Seq_CD4+_Human1.30309914
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29851195
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.28519192
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28196982
86RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28098893
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27743168
88CBP_20019798_ChIP-Seq_JUKART_Human1.27743168
89ER_23166858_ChIP-Seq_MCF-7_Human1.27571495
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27395239
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.27351239
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.25335660
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24330499
94STAT3_23295773_ChIP-Seq_U87_Human1.23722189
95* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22473898
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21330374
97RING1B_27294783_Chip-Seq_ESCs_Mouse1.21032797
98SALL1_21062744_ChIP-ChIP_HESCs_Human1.19159811
99NANOG_19829295_ChIP-Seq_ESCs_Human1.18858906
100SOX2_19829295_ChIP-Seq_ESCs_Human1.18858906
101AR_25329375_ChIP-Seq_VCAP_Human1.18486353
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.18457908
103NANOG_16153702_ChIP-ChIP_HESCs_Human1.18066242
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17975832
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16551654
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15921383
107FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15547555
108YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15214821
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14958938
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.14951055
111TCF4_22108803_ChIP-Seq_LS180_Human1.14305103
112EWS_26573619_Chip-Seq_HEK293_Human1.13501515
113SOX2_16153702_ChIP-ChIP_HESCs_Human1.13232582
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12940670
115FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12759500
116JUN_21703547_ChIP-Seq_K562_Human1.12514888
117P53_22387025_ChIP-Seq_ESCs_Mouse1.12254880
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10768520
119RUNX2_22187159_ChIP-Seq_PCA_Human1.08917355
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08666847
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.08156485
122CDX2_22108803_ChIP-Seq_LS180_Human1.07481479
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06853788
124EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05181234
125SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04849944
126NOTCH1_21737748_ChIP-Seq_TLL_Human1.04700403
127TCF4_23295773_ChIP-Seq_U87_Human1.04686292
128AR_19668381_ChIP-Seq_PC3_Human1.04331169
129SOX9_26525672_Chip-Seq_HEART_Mouse1.02912996
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.02822682
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02429373
132SMAD3_21741376_ChIP-Seq_ESCs_Human1.02169482
133CMYC_18555785_Chip-Seq_ESCs_Mouse1.02134598
134P300_18555785_Chip-Seq_ESCs_Mouse1.01496814
135FOXP3_21729870_ChIP-Seq_TREG_Human1.01467312
136WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01285811
137ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01259549
138TP53_18474530_ChIP-ChIP_U2OS_Human1.00653437
139SRF_21415370_ChIP-Seq_HL-1_Mouse1.00570482
140JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00190466
141EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00120560
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00085882
143SMAD4_21741376_ChIP-Seq_EPCs_Human1.00030470
144SMAD_19615063_ChIP-ChIP_OVARY_Human0.99841368
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98690813
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98104227
147YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97970180
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.97546461
149STAT3_18555785_Chip-Seq_ESCs_Mouse0.97160174
150OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96914297
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96605493
152HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96262166
153CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.96206995
154PRDM14_20953172_ChIP-Seq_ESCs_Human0.95002217
155POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94612955
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93673500
157LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93553011
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.93446624
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.92251525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.60974996
2MP0003880_abnormal_central_pattern4.10849071
3MP0004270_analgesia3.32966708
4MP0003635_abnormal_synaptic_transmissio3.07200047
5MP0003195_calcinosis2.85345480
6MP0008058_abnormal_DNA_repair2.80092357
7MP0003122_maternal_imprinting2.58262473
8MP0005423_abnormal_somatic_nervous2.50189022
9MP0002063_abnormal_learning/memory/cond2.49042972
10MP0001968_abnormal_touch/_nociception2.41802550
11MP0000778_abnormal_nervous_system2.40574666
12MP0002734_abnormal_mechanical_nocicepti2.32971001
13MP0002064_seizures2.25135018
14MP0010094_abnormal_chromosome_stability2.22599100
15MP0005367_renal/urinary_system_phenotyp2.22438562
16MP0000516_abnormal_urinary_system2.22438562
17MP0009046_muscle_twitch2.17989450
18MP0009745_abnormal_behavioral_response2.16691958
19MP0002572_abnormal_emotion/affect_behav1.99459463
20MP0002272_abnormal_nervous_system1.97197126
21MP0002184_abnormal_innervation1.96858928
22MP0002837_dystrophic_cardiac_calcinosis1.91881657
23MP0001486_abnormal_startle_reflex1.89673929
24MP0003718_maternal_effect1.88425651
25MP0006276_abnormal_autonomic_nervous1.87662092
26MP0002735_abnormal_chemical_nociception1.86923798
27MP0006292_abnormal_olfactory_placode1.82048252
28MP0006054_spinal_hemorrhage1.78812671
29MP0008057_abnormal_DNA_replication1.78175986
30MP0004811_abnormal_neuron_physiology1.77497164
31MP0000569_abnormal_digit_pigmentation1.77289000
32MP0002736_abnormal_nociception_after1.74507515
33MP0002733_abnormal_thermal_nociception1.74496173
34MP0000955_abnormal_spinal_cord1.71999688
35MP0003693_abnormal_embryo_hatching1.68750744
36MP0001529_abnormal_vocalization1.68032957
37MP0001299_abnormal_eye_distance/1.66013920
38MP0003119_abnormal_digestive_system1.65985894
39MP0004858_abnormal_nervous_system1.64227923
40MP0005623_abnormal_meninges_morphology1.62201534
41MP0002067_abnormal_sensory_capabilities1.60623947
42MP0009780_abnormal_chondrocyte_physiolo1.59440588
43MP0001970_abnormal_pain_threshold1.58680274
44MP0003121_genomic_imprinting1.54721323
45MP0002557_abnormal_social/conspecific_i1.54606317
46MP0003787_abnormal_imprinting1.54501913
47MP0002882_abnormal_neuron_morphology1.49641523
48MP0004924_abnormal_behavior1.45554980
49MP0005386_behavior/neurological_phenoty1.45554980
50MP0004133_heterotaxia1.44375353
51MP0000372_irregular_coat_pigmentation1.42737374
52MP0001440_abnormal_grooming_behavior1.42604454
53MP0004885_abnormal_endolymph1.41974205
54MP0008569_lethality_at_weaning1.40538793
55MP0001293_anophthalmia1.39010020
56MP0003786_premature_aging1.37151076
57MP0003329_amyloid_beta_deposits1.36607722
58MP0000537_abnormal_urethra_morphology1.34904468
59MP0005645_abnormal_hypothalamus_physiol1.33561253
60MP0002233_abnormal_nose_morphology1.32442746
61MP0003123_paternal_imprinting1.30952058
62MP0002152_abnormal_brain_morphology1.24581418
63MP0001188_hyperpigmentation1.24500857
64MP0008007_abnormal_cellular_replicative1.24193013
65MP0000631_abnormal_neuroendocrine_gland1.24090448
66MP0003941_abnormal_skin_development1.23885194
67MP0004957_abnormal_blastocyst_morpholog1.21839369
68MP0002066_abnormal_motor_capabilities/c1.19096679
69MP0003567_abnormal_fetal_cardiomyocyte1.19084527
70MP0000647_abnormal_sebaceous_gland1.18914991
71MP0001984_abnormal_olfaction1.17524731
72MP0002090_abnormal_vision1.17173678
73MP0000920_abnormal_myelination1.16285563
74MP0000013_abnormal_adipose_tissue1.16057740
75MP0005187_abnormal_penis_morphology1.14335952
76MP0004215_abnormal_myocardial_fiber1.14086622
77MP0002909_abnormal_adrenal_gland1.13931627
78MP0008932_abnormal_embryonic_tissue1.13314963
79MP0005084_abnormal_gallbladder_morpholo1.13166177
80MP0005171_absent_coat_pigmentation1.13038010
81MP0003634_abnormal_glial_cell1.11350954
82MP0003111_abnormal_nucleus_morphology1.09759138
83MP0000427_abnormal_hair_cycle1.09178429
84MP0002163_abnormal_gland_morphology1.09162567
85MP0004742_abnormal_vestibular_system1.09060642
86MP0000534_abnormal_ureter_morphology1.08906682
87MP0001905_abnormal_dopamine_level1.08755773
88MP0005646_abnormal_pituitary_gland1.08405959
89MP0001501_abnormal_sleep_pattern1.08239553
90MP0002751_abnormal_autonomic_nervous1.08139336
91MP0009697_abnormal_copulation1.07618208
92MP0003861_abnormal_nervous_system1.07065398
93MP0004233_abnormal_muscle_weight1.06716787
94MP0001502_abnormal_circadian_rhythm1.02931974
95MP0006072_abnormal_retinal_apoptosis1.02234161
96MP0003011_delayed_dark_adaptation1.01005346
97MP0003385_abnormal_body_wall1.00641121
98MP0002160_abnormal_reproductive_system1.00440755
99MP0010234_abnormal_vibrissa_follicle0.99794362
100MP0000049_abnormal_middle_ear0.99456619
101MP0005379_endocrine/exocrine_gland_phen0.98107919
102MP0001177_atelectasis0.97663743
103MP0002752_abnormal_somatic_nervous0.96390772
104MP0009250_abnormal_appendicular_skeleto0.95364282
105MP0003942_abnormal_urinary_system0.95268532
106MP0005395_other_phenotype0.93849592
107MP0003077_abnormal_cell_cycle0.93814035
108MP0005394_taste/olfaction_phenotype0.90881684
109MP0005499_abnormal_olfactory_system0.90881684
110MP0002938_white_spotting0.90449677
111MP0005503_abnormal_tendon_morphology0.88567424
112MP0001286_abnormal_eye_development0.87888753
113MP0006035_abnormal_mitochondrial_morpho0.86979459
114MP0005248_abnormal_Harderian_gland0.86953510
115MP0005409_darkened_coat_color0.86519701
116MP0005551_abnormal_eye_electrophysiolog0.85954948
117MP0010678_abnormal_skin_adnexa0.85941270
118MP0002638_abnormal_pupillary_reflex0.85795081
119MP0003137_abnormal_impulse_conducting0.85376640
120MP0008872_abnormal_physiological_respon0.85341257
121MP0003633_abnormal_nervous_system0.85199753
122MP0008877_abnormal_DNA_methylation0.84818967
123MP0003631_nervous_system_phenotype0.83801299
124MP0001348_abnormal_lacrimal_gland0.83433359
125MP0004147_increased_porphyrin_level0.81685191
126MP0005391_vision/eye_phenotype0.81671076
127MP0003283_abnormal_digestive_organ0.80862679
128MP0003632_abnormal_nervous_system0.79803335
129MP0005075_abnormal_melanosome_morpholog0.79779214
130MP0002229_neurodegeneration0.79560239
131MP0008789_abnormal_olfactory_epithelium0.77614510
132MP0001943_abnormal_respiration0.76875444
133MP0010386_abnormal_urinary_bladder0.76447977
134MP0002081_perinatal_lethality0.76030734
135MP0002254_reproductive_system_inflammat0.75713400
136MP0005220_abnormal_exocrine_pancreas0.74920313
137* MP0001929_abnormal_gametogenesis0.74619198
138MP0005195_abnormal_posterior_eye0.74286665
139MP0002282_abnormal_trachea_morphology0.73227946
140MP0005389_reproductive_system_phenotype0.72923864
141MP0003755_abnormal_palate_morphology0.72088446
142MP0001485_abnormal_pinna_reflex0.72038632
143MP0003937_abnormal_limbs/digits/tail_de0.71845650
144MP0004134_abnormal_chest_morphology0.71788516
145MP0003938_abnormal_ear_development0.71207035
146MP0002084_abnormal_developmental_patter0.71026787
147MP0005253_abnormal_eye_physiology0.70904263
148MP0001324_abnormal_eye_pigmentation0.70795959
149* MP0000653_abnormal_sex_gland0.70204947
150MP0002234_abnormal_pharynx_morphology0.70015772
151MP0001963_abnormal_hearing_physiology0.69580392
152MP0002177_abnormal_outer_ear0.69480072
153MP0004142_abnormal_muscle_tone0.67186299
154MP0002102_abnormal_ear_morphology0.66388388
155MP0003890_abnormal_embryonic-extraembry0.65424143

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.19420515
2Myokymia (HP:0002411)3.94671087
3Focal motor seizures (HP:0011153)3.73580496
4Focal seizures (HP:0007359)3.34252439
5Ankle clonus (HP:0011448)3.33816886
6Insidious onset (HP:0003587)3.31353316
7Termporal pattern (HP:0011008)3.31353316
8Atonic seizures (HP:0010819)3.25145220
9Pheochromocytoma (HP:0002666)3.13785414
10Progressive cerebellar ataxia (HP:0002073)3.12888711
11Epileptic encephalopathy (HP:0200134)3.09970367
12Visual hallucinations (HP:0002367)3.05245634
13Ependymoma (HP:0002888)3.04802764
14Supranuclear gaze palsy (HP:0000605)3.04076421
15Neoplasm of the adrenal cortex (HP:0100641)2.91167206
16Action tremor (HP:0002345)2.91062937
17Pancreatic cysts (HP:0001737)2.88197292
18Megalencephaly (HP:0001355)2.83894823
19Truncal ataxia (HP:0002078)2.74922495
20Hypothermia (HP:0002045)2.74343105
21Papilledema (HP:0001085)2.74024111
22Neuroendocrine neoplasm (HP:0100634)2.71348574
23Methylmalonic acidemia (HP:0002912)2.69400905
24Colon cancer (HP:0003003)2.68987380
25Abnormality of the corticospinal tract (HP:0002492)2.62800881
26Pancreatic fibrosis (HP:0100732)2.62344064
27Volvulus (HP:0002580)2.61010735
28Absence seizures (HP:0002121)2.57845915
29Neoplasm of the adrenal gland (HP:0100631)2.57529318
30Intestinal atresia (HP:0011100)2.56049558
31Abnormality of chromosome stability (HP:0003220)2.55949705
32Astrocytoma (HP:0009592)2.55616019
33Abnormality of the astrocytes (HP:0100707)2.55616019
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.55493770
35Limb dystonia (HP:0002451)2.52850885
36Meckel diverticulum (HP:0002245)2.52644486
37Urinary urgency (HP:0000012)2.51968600
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.51714965
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.51714965
40Chromosomal breakage induced by crosslinking agents (HP:0003221)2.47607258
41True hermaphroditism (HP:0010459)2.46209958
42Chromsome breakage (HP:0040012)2.45252923
43Hyperinsulinemic hypoglycemia (HP:0000825)2.45074725
44Abnormality of the ileum (HP:0001549)2.43951598
45Glioma (HP:0009733)2.43470127
46Stenosis of the external auditory canal (HP:0000402)2.40379959
47Hypoglycemic seizures (HP:0002173)2.39759829
48Excessive salivation (HP:0003781)2.36339310
49Drooling (HP:0002307)2.36339310
50Agitation (HP:0000713)2.35458209
51Febrile seizures (HP:0002373)2.33635406
52Mutism (HP:0002300)2.32198431
53Abnormality of midbrain morphology (HP:0002418)2.30988660
54Molar tooth sign on MRI (HP:0002419)2.30988660
55Spastic gait (HP:0002064)2.30941453
56Dialeptic seizures (HP:0011146)2.30311789
57Medial flaring of the eyebrow (HP:0010747)2.28999036
58Abnormality of the metopic suture (HP:0005556)2.28723318
59Neurofibrillary tangles (HP:0002185)2.28607207
60Depression (HP:0000716)2.26493898
61Shoulder girdle muscle weakness (HP:0003547)2.24784756
62Ectopic kidney (HP:0000086)2.23205360
63Hypoglycemic coma (HP:0001325)2.20615300
64Progressive macrocephaly (HP:0004481)2.20208571
65Amyotrophic lateral sclerosis (HP:0007354)2.18142023
66Abnormality of the preputium (HP:0100587)2.16416538
67Prominent metopic ridge (HP:0005487)2.15109242
68Lissencephaly (HP:0001339)2.14874081
69Nephronophthisis (HP:0000090)2.13756531
70Urinary bladder sphincter dysfunction (HP:0002839)2.12863616
71Hypoplasia of the brainstem (HP:0002365)2.12777487
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12777487
73Broad-based gait (HP:0002136)2.10445476
74Cerebral inclusion bodies (HP:0100314)2.10051838
75Impaired vibration sensation in the lower limbs (HP:0002166)2.08848920
76Generalized tonic-clonic seizures (HP:0002069)2.08051762
77Acute necrotizing encephalopathy (HP:0006965)2.08037166
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07984372
79Lower limb muscle weakness (HP:0007340)2.07979680
80Rhabdomyosarcoma (HP:0002859)2.07787825
81Abnormal lung lobation (HP:0002101)2.07363885
82Buphthalmos (HP:0000557)2.05622095
83Pancreatic islet-cell hyperplasia (HP:0004510)2.05568576
84Gait imbalance (HP:0002141)2.04873638
85Insomnia (HP:0100785)2.02570202
86Inappropriate behavior (HP:0000719)2.02321181
87Abnormality of the duodenum (HP:0002246)2.01353542
88Neoplasm of the peripheral nervous system (HP:0100007)2.01281989
89Genetic anticipation (HP:0003743)2.00981603
90Hypoventilation (HP:0002791)2.00101433
91Methylmalonic aciduria (HP:0012120)2.00061770
92Acute encephalopathy (HP:0006846)1.98222184
93Duodenal stenosis (HP:0100867)1.97614265
94Small intestinal stenosis (HP:0012848)1.97614265
95Scanning speech (HP:0002168)1.97532576
96Aplasia/Hypoplasia of the tongue (HP:0010295)1.96721059
97Abnormality of endocrine pancreas physiology (HP:0012093)1.95528692
98Abnormality of the pancreatic islet cells (HP:0006476)1.95528692
99Amblyopia (HP:0000646)1.93797915
100Hyperglycinemia (HP:0002154)1.93596971
101Anxiety (HP:0000739)1.90753855
102Abnormality of the parathyroid morphology (HP:0011766)1.89823433
103Poor eye contact (HP:0000817)1.89726218
104Abnormality of methionine metabolism (HP:0010901)1.89662969
105Dysmetria (HP:0001310)1.88021107
106Menstrual irregularities (HP:0000858)1.87882919
107Renal hypoplasia (HP:0000089)1.87779886
108Small hand (HP:0200055)1.87661113
109Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.87082554
110Short 1st metacarpal (HP:0010034)1.87082554
111Abnormality of vitamin B metabolism (HP:0004340)1.86858710
112Adrenal hypoplasia (HP:0000835)1.85314269
113Papillary thyroid carcinoma (HP:0002895)1.84675892
114Abolished electroretinogram (ERG) (HP:0000550)1.84573869
115Progressive inability to walk (HP:0002505)1.84336631
116Akinesia (HP:0002304)1.84008335
117Preaxial hand polydactyly (HP:0001177)1.82858877
118EEG with generalized epileptiform discharges (HP:0011198)1.82790379
119Aqueductal stenosis (HP:0002410)1.81751719
120Epileptiform EEG discharges (HP:0011182)1.81453775
121Delayed gross motor development (HP:0002194)1.80822416
122Labial hypoplasia (HP:0000066)1.80815782
123Gastrointestinal atresia (HP:0002589)1.80418349
124Abnormal eating behavior (HP:0100738)1.80056599
125Hypoplastic female external genitalia (HP:0012815)1.78551271
126Retinal dysplasia (HP:0007973)1.78476067
127Impaired smooth pursuit (HP:0007772)1.78337641
128Gaze-evoked nystagmus (HP:0000640)1.78189612
129Pendular nystagmus (HP:0012043)1.78082779
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77848033
131Heterochromia iridis (HP:0001100)1.77057593
132Sloping forehead (HP:0000340)1.76652723
133Hypsarrhythmia (HP:0002521)1.76534390
134Hemiparesis (HP:0001269)1.76372690
135Genital tract atresia (HP:0001827)1.75981701
136Hypoplastic pelvis (HP:0008839)1.74483736
137Apathy (HP:0000741)1.73800877
138Hyperglycemia (HP:0003074)1.73504851
139Short 4th metacarpal (HP:0010044)1.73417443
140Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73417443
141Macroorchidism (HP:0000053)1.73375359
142Vaginal atresia (HP:0000148)1.73345821
143Supernumerary spleens (HP:0009799)1.73317136
144Breast carcinoma (HP:0003002)1.73140537
145Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.73006591
146Decreased muscle mass (HP:0003199)1.72817815
147Abnormality of the renal medulla (HP:0100957)1.72431094
148Increased CSF lactate (HP:0002490)1.72147038
149Clonus (HP:0002169)1.72126659
150Sclerocornea (HP:0000647)1.71887383
151Dandy-Walker malformation (HP:0001305)1.71822291
152Dysdiadochokinesis (HP:0002075)1.71585266
153Abnormality of serum amino acid levels (HP:0003112)1.71058805
154Ankyloglossia (HP:0010296)1.70005434
155Pointed chin (HP:0000307)1.69575974
156Nephrogenic diabetes insipidus (HP:0009806)1.69369966
157Specific learning disability (HP:0001328)1.68223577
158Abnormality of salivation (HP:0100755)1.68208205
159Sensory axonal neuropathy (HP:0003390)1.67749027
160Bifid tongue (HP:0010297)1.66831195
161Cystic liver disease (HP:0006706)1.66715721
162Overriding aorta (HP:0002623)1.66701404
163Inability to walk (HP:0002540)1.65954972
164Ketoacidosis (HP:0001993)1.64886521
165Sacral dimple (HP:0000960)1.64518287
166Narrow forehead (HP:0000341)1.64232534
167Abnormality of the vitamin B12 metabolism (HP:0004341)1.63942628
168Intention tremor (HP:0002080)1.63733901
169Hypomagnesemia (HP:0002917)1.63190209
170Polyphagia (HP:0002591)1.62924300
171Symptomatic seizures (HP:0011145)1.62915741
172Absent speech (HP:0001344)1.62685953
173Microglossia (HP:0000171)1.62487409
174Blue irides (HP:0000635)1.62092960
175Hypoplasia of the fovea (HP:0007750)1.61015134
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.61015134
177Hyperthyroidism (HP:0000836)1.61006811
178Asymmetry of the thorax (HP:0001555)1.60954760
179Thin upper lip vermilion (HP:0000219)1.60494649
180Abnormal hair whorl (HP:0010721)1.60315921
181Horseshoe kidney (HP:0000085)1.60124298
182Failure to thrive in infancy (HP:0001531)1.59956035
183Posterior subcapsular cataract (HP:0007787)1.59808933
184Abnormality of the 1st metacarpal (HP:0010009)1.59490433
185Thyroid carcinoma (HP:0002890)1.59404489
186Neoplasm of the heart (HP:0100544)1.59219610
187Stereotypic behavior (HP:0000733)1.58502008
188Renal duplication (HP:0000075)1.58470520
189Abnormality of the hip-girdle musculature (HP:0001445)1.57883405
190Abnormality of the musculature of the pelvis (HP:0001469)1.57883405
191Congenital primary aphakia (HP:0007707)1.57364795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.70263592
2FRK3.62384594
3TRIM283.55697540
4NTRK33.26562118
5MINK12.98683672
6NEK12.89127188
7MAP3K42.78169141
8MKNK22.76928151
9MAP3K92.64918726
10ERBB32.55336866
11LIMK12.40159801
12MAP2K72.37669204
13BUB12.36417045
14MST42.26436249
15NUAK12.23069836
16TSSK62.21147899
17EPHA42.18409419
18PAK62.07471270
19EIF2AK32.04783041
20KSR11.98506542
21MAP4K21.97759149
22BCR1.97342501
23PLK21.96776741
24ZAK1.94566933
25NTRK11.86258930
26NTRK21.85283225
27UHMK11.83742881
28ACVR1B1.83737586
29BRSK21.81680685
30MAPK131.80105379
31CASK1.77144214
32STK391.70987897
33PRKD31.66838949
34SRPK11.59839721
35KSR21.58723745
36MAP3K21.51913209
37PLK41.49985902
38TTK1.49551685
39EIF2AK11.48447776
40DYRK21.46673947
41VRK21.44860530
42GRK11.44510189
43PAK31.44273242
44CDK51.43658296
45CDK141.36625856
46CSNK1G21.30983776
47STK38L1.30296416
48WEE11.29893273
49CDK191.29498661
50LATS21.24592426
51CDK181.24417290
52TESK11.23764328
53PNCK1.21326815
54OXSR11.18804538
55CDK151.17423159
56DAPK21.15806842
57FGFR21.15736089
58CAMKK21.15159591
59MUSK1.14909790
60CAMKK11.14316881
61PLK11.09370229
62VRK11.08442024
63CSNK1G31.06962682
64SGK4941.06953793
65SGK2231.06953793
66MAP2K41.06061651
67CDC71.05648147
68INSRR1.05036672
69SCYL21.04967657
70CDK11A1.02442376
71STK161.01631464
72MAP3K121.00355541
73RET0.96540116
74TAF10.94361409
75CSNK1A1L0.92754358
76WNK10.90650974
77PRKCG0.90588606
78FER0.89639355
79PHKG10.88681664
80PHKG20.88681664
81TNIK0.88111477
82WNK30.87205452
83CAMK2B0.83774309
84BRSK10.83629968
85ADRBK20.83599571
86PLK30.81544539
87STK30.81465873
88CAMK2A0.79581156
89WNK40.77602427
90DDR20.77354446
91ARAF0.74871109
92ROCK20.73397443
93PBK0.72405789
94PINK10.71022595
95TGFBR10.70137815
96BMPR1B0.68503791
97RIPK40.68473741
98GRK50.67686046
99ERBB40.67209649
100DYRK1A0.66452745
101MAPKAPK50.64535956
102BCKDK0.64476171
103CCNB10.64246234
104SIK30.63875836
105TYRO30.63726293
106PRKCE0.63437749
107FGFR10.62001406
108NLK0.61673071
109CSNK1G10.60756668
110EIF2AK20.59647561
111ATM0.58936161
112ATR0.58397249
113EPHB20.57723524
114PTK2B0.57389460
115NEK60.57345204
116TIE10.56516959
117LMTK20.53230011
118PRKCI0.51647776
119STK240.51306994
120PKN10.51191557
121PRKCH0.50565312
122DAPK10.50262346
123FLT30.49004918
124MKNK10.48252036
125PRPF4B0.47992673
126EPHA30.47278225
127CAMK2D0.47218697
128AKT30.47032562
129PASK0.46321343
130PDGFRA0.45831642
131MAPK100.44427023
132FGR0.43638522
133BMPR20.43379345
134STK110.43370932
135FYN0.42382770
136PRKCZ0.40663866
137SGK20.40241629
138CHEK20.39930689
139RPS6KA20.39292339
140HIPK20.38321774
141PDK20.37646280
142CAMK1G0.37086182
143ADRBK10.36988040
144ROCK10.36969970
145CDC42BPA0.35160853
146SGK10.34657336
147CAMK2G0.34063175
148PRKDC0.32322966
149CSNK1A10.32266887
150CSNK2A10.31542382
151DYRK30.31191206
152CSNK1E0.29563784
153CSNK1D0.28166440
154PRKACB0.27164967
155AURKB0.27136563

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.53843804
2Non-homologous end-joining_Homo sapiens_hsa034503.16121279
3Proteasome_Homo sapiens_hsa030502.97714295
4Synaptic vesicle cycle_Homo sapiens_hsa047212.69977003
5Nicotine addiction_Homo sapiens_hsa050332.57925054
6Propanoate metabolism_Homo sapiens_hsa006402.30234016
7Mismatch repair_Homo sapiens_hsa034302.26667746
8Homologous recombination_Homo sapiens_hsa034402.25331176
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.24889691
10GABAergic synapse_Homo sapiens_hsa047272.19151774
11Fanconi anemia pathway_Homo sapiens_hsa034602.14124220
12Long-term potentiation_Homo sapiens_hsa047202.12416897
13Steroid biosynthesis_Homo sapiens_hsa001002.12279425
14Circadian entrainment_Homo sapiens_hsa047132.08795424
15Vitamin B6 metabolism_Homo sapiens_hsa007502.08055525
16Dopaminergic synapse_Homo sapiens_hsa047282.04600928
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02806530
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.97523636
19RNA degradation_Homo sapiens_hsa030181.97101529
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95834854
21Glutamatergic synapse_Homo sapiens_hsa047241.95535073
22Basal transcription factors_Homo sapiens_hsa030221.93363369
23Amphetamine addiction_Homo sapiens_hsa050311.92642850
24Morphine addiction_Homo sapiens_hsa050321.91340744
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90613839
26Olfactory transduction_Homo sapiens_hsa047401.90147861
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88153609
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.87771834
29RNA polymerase_Homo sapiens_hsa030201.84018955
30Axon guidance_Homo sapiens_hsa043601.76780413
31Butanoate metabolism_Homo sapiens_hsa006501.68235744
32Cholinergic synapse_Homo sapiens_hsa047251.67059942
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64850554
34Fatty acid elongation_Homo sapiens_hsa000621.64225241
35Serotonergic synapse_Homo sapiens_hsa047261.61692245
36Cocaine addiction_Homo sapiens_hsa050301.61199026
37Long-term depression_Homo sapiens_hsa047301.59394712
38RNA transport_Homo sapiens_hsa030131.58787173
39Insulin secretion_Homo sapiens_hsa049111.55671059
40Selenocompound metabolism_Homo sapiens_hsa004501.54952904
41One carbon pool by folate_Homo sapiens_hsa006701.54839502
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52644902
43Sulfur metabolism_Homo sapiens_hsa009201.48014613
44Gap junction_Homo sapiens_hsa045401.45069043
45Oocyte meiosis_Homo sapiens_hsa041141.43155890
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.40833670
47Taste transduction_Homo sapiens_hsa047421.39551546
48Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38753463
49Renin secretion_Homo sapiens_hsa049241.37028243
50Vibrio cholerae infection_Homo sapiens_hsa051101.35354401
51Salivary secretion_Homo sapiens_hsa049701.33689380
52Gastric acid secretion_Homo sapiens_hsa049711.32530035
53DNA replication_Homo sapiens_hsa030301.29764562
54Oxidative phosphorylation_Homo sapiens_hsa001901.29374850
55Oxytocin signaling pathway_Homo sapiens_hsa049211.28218161
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25523246
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24554557
58Glioma_Homo sapiens_hsa052141.24211655
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22929804
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22662452
61ErbB signaling pathway_Homo sapiens_hsa040121.21643909
62Collecting duct acid secretion_Homo sapiens_hsa049661.20244624
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19643715
64GnRH signaling pathway_Homo sapiens_hsa049121.18443177
65Nucleotide excision repair_Homo sapiens_hsa034201.16101712
66Estrogen signaling pathway_Homo sapiens_hsa049151.15913352
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.14414208
68Alcoholism_Homo sapiens_hsa050341.14134497
69Melanogenesis_Homo sapiens_hsa049161.14019346
70Cell cycle_Homo sapiens_hsa041101.13825691
71Pyruvate metabolism_Homo sapiens_hsa006201.11699168
72Renal cell carcinoma_Homo sapiens_hsa052111.11515676
73Parkinsons disease_Homo sapiens_hsa050121.08613039
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08003851
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06646427
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.04633823
77Phototransduction_Homo sapiens_hsa047441.03966486
78SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01657793
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99192066
80Nitrogen metabolism_Homo sapiens_hsa009100.98663755
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97388026
82cAMP signaling pathway_Homo sapiens_hsa040240.96851327
83Peroxisome_Homo sapiens_hsa041460.96826421
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.95241318
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94847850
86Dorso-ventral axis formation_Homo sapiens_hsa043200.92791454
87Tryptophan metabolism_Homo sapiens_hsa003800.92781569
88Type II diabetes mellitus_Homo sapiens_hsa049300.91740926
89Colorectal cancer_Homo sapiens_hsa052100.91543183
90Endometrial cancer_Homo sapiens_hsa052130.89643935
91Wnt signaling pathway_Homo sapiens_hsa043100.89505643
92Base excision repair_Homo sapiens_hsa034100.88646922
93Purine metabolism_Homo sapiens_hsa002300.87694566
94Calcium signaling pathway_Homo sapiens_hsa040200.87247665
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86328379
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86168671
97Endocytosis_Homo sapiens_hsa041440.86127059
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85924699
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82604618
100Hedgehog signaling pathway_Homo sapiens_hsa043400.81783735
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81720362
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81103108
103Caffeine metabolism_Homo sapiens_hsa002320.79456825
104Fatty acid metabolism_Homo sapiens_hsa012120.79447255
105Hippo signaling pathway_Homo sapiens_hsa043900.79208025
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79164063
107Ras signaling pathway_Homo sapiens_hsa040140.77796618
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.77626295
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77607711
110Phospholipase D signaling pathway_Homo sapiens_hsa040720.77371929
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77283988
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.76736707
113TGF-beta signaling pathway_Homo sapiens_hsa043500.75163258
114Huntingtons disease_Homo sapiens_hsa050160.74902516
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.74595759
116MAPK signaling pathway_Homo sapiens_hsa040100.74113200
117beta-Alanine metabolism_Homo sapiens_hsa004100.74108332
118Pyrimidine metabolism_Homo sapiens_hsa002400.73651958
119Regulation of autophagy_Homo sapiens_hsa041400.73490683
120p53 signaling pathway_Homo sapiens_hsa041150.73060955
121Spliceosome_Homo sapiens_hsa030400.72381170
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71920710
123Thyroid hormone synthesis_Homo sapiens_hsa049180.71579755
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70993394
125VEGF signaling pathway_Homo sapiens_hsa043700.70717729
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68859629
127Rap1 signaling pathway_Homo sapiens_hsa040150.68449030
128Choline metabolism in cancer_Homo sapiens_hsa052310.68389088
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67811930
130mRNA surveillance pathway_Homo sapiens_hsa030150.65707724
131Tight junction_Homo sapiens_hsa045300.63883807
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63877116
133* Metabolic pathways_Homo sapiens_hsa011000.63017129
134Alzheimers disease_Homo sapiens_hsa050100.62862858
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62195273
136mTOR signaling pathway_Homo sapiens_hsa041500.62066473
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61968693
138Phagosome_Homo sapiens_hsa041450.61438722
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61142934
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61056695
141Melanoma_Homo sapiens_hsa052180.60670216
142Non-small cell lung cancer_Homo sapiens_hsa052230.60559691
143Cardiac muscle contraction_Homo sapiens_hsa042600.60531521
144Fatty acid degradation_Homo sapiens_hsa000710.60135397
145Dilated cardiomyopathy_Homo sapiens_hsa054140.59945577
146Glutathione metabolism_Homo sapiens_hsa004800.57863199
147Circadian rhythm_Homo sapiens_hsa047100.57353134
148Retinol metabolism_Homo sapiens_hsa008300.56902166
149Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54164492
150Type I diabetes mellitus_Homo sapiens_hsa049400.52902224
151Pancreatic secretion_Homo sapiens_hsa049720.51517098
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49970649
153Salmonella infection_Homo sapiens_hsa051320.49643903
154Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49033009
155Linoleic acid metabolism_Homo sapiens_hsa005910.48470583
156Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47758064
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47661791
158Proteoglycans in cancer_Homo sapiens_hsa052050.47583103
159Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47421582
160Focal adhesion_Homo sapiens_hsa045100.47242621
161Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46987490
162Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46540093
163Pancreatic cancer_Homo sapiens_hsa052120.46387912
164Basal cell carcinoma_Homo sapiens_hsa052170.46320097
165Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45660643
166Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45064519
167* Ether lipid metabolism_Homo sapiens_hsa005650.43879870
168Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42780440
169Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41966941
170Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40885522
171N-Glycan biosynthesis_Homo sapiens_hsa005100.40726719
172Carbon metabolism_Homo sapiens_hsa012000.39783036
173Folate biosynthesis_Homo sapiens_hsa007900.38874524
174alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36482972

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