PAFAH1B3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.96038956
2ribosomal small subunit assembly (GO:0000028)6.79519158
3translational termination (GO:0006415)6.59025077
4ribosomal small subunit biogenesis (GO:0042274)6.16955042
5translational elongation (GO:0006414)5.71820424
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.65257857
7cotranslational protein targeting to membrane (GO:0006613)5.54989695
8viral life cycle (GO:0019058)5.53721798
9protein targeting to ER (GO:0045047)5.51915240
10cellular protein complex disassembly (GO:0043624)5.36579463
11maturation of SSU-rRNA (GO:0030490)5.24011197
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.20095277
13protein localization to endoplasmic reticulum (GO:0070972)5.18157097
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.16089783
15protein complex disassembly (GO:0043241)5.08613881
16sequestering of actin monomers (GO:0042989)4.86784535
17translational initiation (GO:0006413)4.81742470
18macromolecular complex disassembly (GO:0032984)4.77203556
19negative regulation of RNA splicing (GO:0033119)4.65165813
20nucleobase catabolic process (GO:0046113)4.64785675
21fat-soluble vitamin biosynthetic process (GO:0042362)4.54547698
22DNA damage response, detection of DNA damage (GO:0042769)4.40746517
23ribosomal large subunit biogenesis (GO:0042273)4.15901619
24chaperone-mediated protein transport (GO:0072321)4.06413620
25negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.06267336
26establishment of mitochondrion localization (GO:0051654)3.96643607
27regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.96462252
28pyrimidine nucleobase catabolic process (GO:0006208)3.82221984
29nucleosome disassembly (GO:0006337)3.77727252
30protein-DNA complex disassembly (GO:0032986)3.77727252
31protein complex biogenesis (GO:0070271)3.70760901
32nuclear-transcribed mRNA catabolic process (GO:0000956)3.69344978
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.69020110
34gastrulation with mouth forming second (GO:0001702)3.67172654
35viral mRNA export from host cell nucleus (GO:0046784)3.66670285
36translation (GO:0006412)3.60441662
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.56905005
38NADH dehydrogenase complex assembly (GO:0010257)3.56905005
39mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56905005
40cullin deneddylation (GO:0010388)3.55917577
41cell migration in hindbrain (GO:0021535)3.53702654
42protein targeting to membrane (GO:0006612)3.50901136
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.50867765
44mitochondrial respiratory chain complex assembly (GO:0033108)3.48666596
45mRNA catabolic process (GO:0006402)3.46932340
46telomere maintenance via semi-conservative replication (GO:0032201)3.40466972
47spliceosomal snRNP assembly (GO:0000387)3.38690194
48ectoderm development (GO:0007398)3.38315130
49protein deneddylation (GO:0000338)3.34152863
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.33969227
51negative regulation of mRNA processing (GO:0050686)3.32307337
52respiratory electron transport chain (GO:0022904)3.32120883
53mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.31672768
54DNA strand elongation involved in DNA replication (GO:0006271)3.31449959
55mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30094832
56energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28923865
57ATP synthesis coupled proton transport (GO:0015986)3.28923865
58electron transport chain (GO:0022900)3.26732178
59establishment of integrated proviral latency (GO:0075713)3.24000035
60RNA catabolic process (GO:0006401)3.23211608
61de novo posttranslational protein folding (GO:0051084)3.21850656
62positive regulation of mitochondrial fission (GO:0090141)3.21122028
63histone H2A acetylation (GO:0043968)3.20207521
64regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.20014519
65de novo protein folding (GO:0006458)3.18680773
66ribonucleoprotein complex biogenesis (GO:0022613)3.17254014
67DNA strand elongation (GO:0022616)3.14851366
68regulation of mitochondrial translation (GO:0070129)3.14086778
69peptidyl-arginine omega-N-methylation (GO:0035247)3.13353897
70protein-cofactor linkage (GO:0018065)3.12926004
71negative regulation of microtubule polymerization (GO:0031115)3.12810891
72microtubule depolymerization (GO:0007019)3.12301625
73positive thymic T cell selection (GO:0045059)3.07888965
74GTP biosynthetic process (GO:0006183)3.05933103
75kinetochore assembly (GO:0051382)3.04810006
76formation of translation preinitiation complex (GO:0001731)3.02798635
77protein neddylation (GO:0045116)2.99823383
78guanosine-containing compound biosynthetic process (GO:1901070)2.99683717
79substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.94714021
80substrate-independent telencephalic tangential migration (GO:0021826)2.94714021
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93809834
82neuron cell-cell adhesion (GO:0007158)2.92979024
83mitochondrion transport along microtubule (GO:0047497)2.92425049
84establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.92425049
85telomere maintenance via recombination (GO:0000722)2.91523696
86behavioral response to nicotine (GO:0035095)2.91479932
87histone arginine methylation (GO:0034969)2.89418317
88negative regulation of telomere maintenance (GO:0032205)2.88485496
89termination of RNA polymerase III transcription (GO:0006386)2.88317187
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.88317187
91viral protein processing (GO:0019082)2.86349486
92base-excision repair, AP site formation (GO:0006285)2.85748912
93protein localization to synapse (GO:0035418)2.83656568
94spliceosomal complex assembly (GO:0000245)2.83467201
95iron-sulfur cluster assembly (GO:0016226)2.81117565
96metallo-sulfur cluster assembly (GO:0031163)2.81117565
97mRNA splicing, via spliceosome (GO:0000398)2.80655459
98RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.80655459
99positive regulation of RNA splicing (GO:0033120)2.79397418
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79237188
101negative regulation of ligase activity (GO:0051352)2.79237188
102UTP biosynthetic process (GO:0006228)2.79148672
103peptidyl-arginine methylation (GO:0018216)2.78667611
104peptidyl-arginine N-methylation (GO:0035246)2.78667611
105presynaptic membrane assembly (GO:0097105)2.78458121
106neurofilament cytoskeleton organization (GO:0060052)2.77413226
107RNA splicing, via transesterification reactions (GO:0000375)2.75717881
108presynaptic membrane organization (GO:0097090)2.73506479
109neuron recognition (GO:0008038)2.73483335
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73003041
111mitotic recombination (GO:0006312)2.72681121
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68612472
113postsynaptic membrane organization (GO:0001941)2.68375281
114facial nerve structural organization (GO:0021612)2.68210895
115transcription-coupled nucleotide-excision repair (GO:0006283)2.67550810
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66618025
117regulation of protein heterodimerization activity (GO:0043497)2.66420581
118positive regulation of viral transcription (GO:0050434)2.66277859
119establishment of viral latency (GO:0019043)2.65076445
120cellular component biogenesis (GO:0044085)2.63945568
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63805164
122regulation of mRNA splicing, via spliceosome (GO:0048024)2.62975872
123DNA double-strand break processing (GO:0000729)2.62239207
124DNA unwinding involved in DNA replication (GO:0006268)2.61925331
125nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61674545
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.61150065
127protein polyglutamylation (GO:0018095)2.61145631
128RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60457942
129tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60457942
130protein insertion into membrane (GO:0051205)2.60266478
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.60150692
132termination of RNA polymerase II transcription (GO:0006369)2.59591687
133protein localization to mitochondrion (GO:0070585)2.58952561
134axonal fasciculation (GO:0007413)2.58628629
135kinetochore organization (GO:0051383)2.58568781
136rRNA processing (GO:0006364)2.58474000
137establishment of protein localization to mitochondrion (GO:0072655)2.57764417
138protein targeting to mitochondrion (GO:0006626)2.57214335
139retinal ganglion cell axon guidance (GO:0031290)2.56746385
140proteasome assembly (GO:0043248)2.55650062
141synapse assembly (GO:0007416)2.55332003
142pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54875910
143DNA deamination (GO:0045006)2.52580152
144gamma-aminobutyric acid transport (GO:0015812)2.51466838
145respiratory chain complex IV assembly (GO:0008535)2.51251732
146DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50982479
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50677540
148intraciliary transport (GO:0042073)2.50497498
149regulation of cellular amino acid metabolic process (GO:0006521)2.49866425
150signal transduction involved in cell cycle checkpoint (GO:0072395)2.49337833
151resolution of meiotic recombination intermediates (GO:0000712)2.48526473
152DNA replication initiation (GO:0006270)2.48271167
153modulation by virus of host process (GO:0019054)2.47736443
154nonmotile primary cilium assembly (GO:0035058)2.47099497
155ubiquinone metabolic process (GO:0006743)2.46264469
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43820326
157hydrogen ion transmembrane transport (GO:1902600)2.42456352
158limb bud formation (GO:0060174)2.41442352
159protein localization to cilium (GO:0061512)2.40322970
160hippocampus development (GO:0021766)2.40140379
161pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.37052407
162pyrimidine nucleotide catabolic process (GO:0006244)2.36268385
163purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.35607931
164vocalization behavior (GO:0071625)2.33635673
165purine nucleoside triphosphate biosynthetic process (GO:0009145)2.32990418
166water-soluble vitamin biosynthetic process (GO:0042364)2.31755832
167regulation of synapse structural plasticity (GO:0051823)2.31588885
168energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.29809277
169ATP hydrolysis coupled proton transport (GO:0015991)2.29809277
170cytochrome complex assembly (GO:0017004)2.29272616

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse7.20156214
2E2F7_22180533_ChIP-Seq_HELA_Human4.45495474
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.93085504
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.48674422
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.33488583
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21437963
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06866282
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.00155253
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.90611337
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75936372
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.70180137
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68373683
13XRN2_22483619_ChIP-Seq_HELA_Human2.65982449
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57546709
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52330241
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44890267
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.43375640
18* ZNF274_21170338_ChIP-Seq_K562_Hela2.34456874
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33290897
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30315438
21KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.28367310
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.25934066
23VDR_23849224_ChIP-Seq_CD4+_Human2.22340538
24TTF2_22483619_ChIP-Seq_HELA_Human2.20616498
25EZH2_22144423_ChIP-Seq_EOC_Human2.20223620
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.18353427
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15711244
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13974734
29DCP1A_22483619_ChIP-Seq_HELA_Human2.06325707
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.04796294
31CIITA_25753668_ChIP-Seq_RAJI_Human2.04770512
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03035234
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99678304
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.99157520
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.89231216
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88277400
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.78713227
38IGF1R_20145208_ChIP-Seq_DFB_Human1.78637462
39GABP_19822575_ChIP-Seq_HepG2_Human1.73463620
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.72968878
41* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72151560
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71565858
43* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70961617
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67502844
45VDR_21846776_ChIP-Seq_THP-1_Human1.67054067
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66160932
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.66078926
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65958628
49MYC_22102868_ChIP-Seq_BL_Human1.65694107
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61120110
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59949431
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56837600
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54901727
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.54854502
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54398429
56REST_21632747_ChIP-Seq_MESCs_Mouse1.49798857
57* REST_18959480_ChIP-ChIP_MESCs_Mouse1.49043672
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46876524
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42216958
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36613794
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34286011
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33930221
63* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33136256
64ELK1_19687146_ChIP-ChIP_HELA_Human1.31252418
65MYC_18940864_ChIP-ChIP_HL60_Human1.30425186
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29706621
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29595245
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29133505
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27951019
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24514256
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.23535115
72GBX2_23144817_ChIP-Seq_PC3_Human1.23161248
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.22736822
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22668649
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.21490960
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21406838
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20451077
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18663052
79* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16556225
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15631428
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14024857
82FUS_26573619_Chip-Seq_HEK293_Human1.13765124
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12600659
84EWS_26573619_Chip-Seq_HEK293_Human1.10731790
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10486213
86VDR_22108803_ChIP-Seq_LS180_Human1.09728495
87CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09327681
88TAF15_26573619_Chip-Seq_HEK293_Human1.09006118
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.08534836
90ELK1_22589737_ChIP-Seq_MCF10A_Human1.08260604
91* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07730073
92GATA1_26923725_Chip-Seq_HPCs_Mouse1.07524895
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03765877
94RNF2_27304074_Chip-Seq_NSC_Mouse1.02653711
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02614327
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01597355
97TP53_22573176_ChIP-Seq_HFKS_Human1.00852519
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99811192
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99672347
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.98991746
101VDR_24763502_ChIP-Seq_THP-1_Human0.98761711
102PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98495792
103EED_16625203_ChIP-ChIP_MESCs_Mouse0.97819659
104MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97213639
105YY1_22570637_ChIP-Seq_MALME-3M_Human0.97119954
106* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96883138
107EZH2_27304074_Chip-Seq_ESCs_Mouse0.96692840
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96034638
109IRF1_19129219_ChIP-ChIP_H3396_Human0.94606983
110NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93174614
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93009372
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92844841
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92568310
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91940167
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.91819908
116KDM5A_27292631_Chip-Seq_BREAST_Human0.91804757
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.91591848
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89644606
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.89324261
120FOXP1_21924763_ChIP-Seq_HESCs_Human0.88668078
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.86866564
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86576250
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86062060
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85455466
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85314206
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85185394
127E2F1_21310950_ChIP-Seq_MCF-7_Human0.84467371
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84108261
129SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.83562799
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83551672
131EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82661170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.88439526
2MP0003303_peritoneal_inflammation3.85068633
3MP0003646_muscle_fatigue3.40696160
4MP0003938_abnormal_ear_development3.24352154
5MP0009278_abnormal_bone_marrow2.93183600
6MP0002822_catalepsy2.82829606
7MP0002102_abnormal_ear_morphology2.74307082
8MP0006292_abnormal_olfactory_placode2.69693692
9MP0008789_abnormal_olfactory_epithelium2.59892560
10MP0003693_abnormal_embryo_hatching2.45247670
11MP0006276_abnormal_autonomic_nervous2.40303343
12MP0004859_abnormal_synaptic_plasticity2.27729785
13MP0000778_abnormal_nervous_system2.18398842
14MP0003315_abnormal_perineum_morphology2.13351104
15MP0003111_abnormal_nucleus_morphology2.11785411
16MP0005394_taste/olfaction_phenotype2.10344212
17MP0005499_abnormal_olfactory_system2.10344212
18MP0010030_abnormal_orbit_morphology2.01200011
19MP0003122_maternal_imprinting1.98255612
20MP0004270_analgesia1.98086515
21MP0000049_abnormal_middle_ear1.97191830
22MP0001984_abnormal_olfaction1.95649251
23MP0008995_early_reproductive_senescence1.93883302
24MP0002736_abnormal_nociception_after1.85620353
25MP0003787_abnormal_imprinting1.83456618
26MP0003077_abnormal_cell_cycle1.83177417
27MP0008007_abnormal_cellular_replicative1.75101378
28MP0004133_heterotaxia1.73929966
29MP0002751_abnormal_autonomic_nervous1.72720028
30MP0001968_abnormal_touch/_nociception1.70635957
31MP0000537_abnormal_urethra_morphology1.70378502
32MP0003635_abnormal_synaptic_transmissio1.69180023
33MP0009046_muscle_twitch1.67605210
34MP0003121_genomic_imprinting1.63699289
35MP0000538_abnormal_urinary_bladder1.63225725
36MP0008877_abnormal_DNA_methylation1.62693420
37MP0003890_abnormal_embryonic-extraembry1.61281015
38MP0009745_abnormal_behavioral_response1.59032418
39MP0005076_abnormal_cell_differentiation1.56666036
40MP0002653_abnormal_ependyma_morphology1.55325578
41MP0004142_abnormal_muscle_tone1.55225159
42MP0002735_abnormal_chemical_nociception1.55054292
43MP0002272_abnormal_nervous_system1.51815793
44MP0010094_abnormal_chromosome_stability1.49677758
45MP0002734_abnormal_mechanical_nocicepti1.49392615
46MP0004957_abnormal_blastocyst_morpholog1.48750592
47MP0002063_abnormal_learning/memory/cond1.47650563
48MP0000955_abnormal_spinal_cord1.46833194
49MP0002572_abnormal_emotion/affect_behav1.46667064
50MP0001188_hyperpigmentation1.43777874
51MP0003942_abnormal_urinary_system1.39633102
52MP0001529_abnormal_vocalization1.39321887
53MP0001286_abnormal_eye_development1.38093099
54MP0002697_abnormal_eye_size1.37710205
55MP0004811_abnormal_neuron_physiology1.35744624
56MP0003861_abnormal_nervous_system1.33672437
57MP0000490_abnormal_crypts_of1.31502011
58MP0002064_seizures1.30803715
59MP0001486_abnormal_startle_reflex1.29713481
60MP0003123_paternal_imprinting1.28675380
61MP0002938_white_spotting1.27114077
62MP0004808_abnormal_hematopoietic_stem1.26613669
63MP0003567_abnormal_fetal_cardiomyocyte1.26072924
64MP0002882_abnormal_neuron_morphology1.25126416
65MP0002733_abnormal_thermal_nociception1.25029096
66MP0005174_abnormal_tail_pigmentation1.24828833
67MP0005397_hematopoietic_system_phenotyp1.24509637
68MP0001545_abnormal_hematopoietic_system1.24509637
69MP0005084_abnormal_gallbladder_morpholo1.24258065
70MP0003119_abnormal_digestive_system1.23712767
71MP0000566_synostosis1.23641520
72MP0001293_anophthalmia1.22546270
73MP0003136_yellow_coat_color1.22528649
74MP0001970_abnormal_pain_threshold1.20034917
75MP0000858_altered_metastatic_potential1.19707676
76MP0002752_abnormal_somatic_nervous1.19099717
77MP0000631_abnormal_neuroendocrine_gland1.18881358
78MP0002638_abnormal_pupillary_reflex1.18134216
79MP0003718_maternal_effect1.16248493
80MP0008932_abnormal_embryonic_tissue1.15873611
81MP0005220_abnormal_exocrine_pancreas1.15824845
82MP0003115_abnormal_respiratory_system1.15100922
83MP0006035_abnormal_mitochondrial_morpho1.13691207
84MP0002282_abnormal_trachea_morphology1.13495331
85MP0002067_abnormal_sensory_capabilities1.13245386
86MP0003786_premature_aging1.13143710
87MP0000026_abnormal_inner_ear1.12451393
88MP0003385_abnormal_body_wall1.11931889
89MP0005386_behavior/neurological_phenoty1.09265910
90MP0004924_abnormal_behavior1.09265910
91MP0002163_abnormal_gland_morphology1.07052314
92MP0005551_abnormal_eye_electrophysiolog1.05915285
93MP0005645_abnormal_hypothalamus_physiol1.05071189
94MP0004742_abnormal_vestibular_system1.05064069
95MP0002184_abnormal_innervation1.04184121
96MP0002249_abnormal_larynx_morphology1.03790788
97MP0005423_abnormal_somatic_nervous1.03059588
98MP0008058_abnormal_DNA_repair1.02293137
99MP0005646_abnormal_pituitary_gland1.01854818
100MP0000350_abnormal_cell_proliferation1.01549273
101MP0002132_abnormal_respiratory_system1.00498352
102MP0002234_abnormal_pharynx_morphology0.98824657
103MP0000313_abnormal_cell_death0.93650698
104MP0003011_delayed_dark_adaptation0.93512379
105MP0001324_abnormal_eye_pigmentation0.93021169
106MP0000678_abnormal_parathyroid_gland0.92868967
107MP0002160_abnormal_reproductive_system0.92595129
108MP0001270_distended_abdomen0.92207623
109MP0002066_abnormal_motor_capabilities/c0.91411617
110MP0005253_abnormal_eye_physiology0.90600553
111MP0000703_abnormal_thymus_morphology0.88628752
112MP0002085_abnormal_embryonic_tissue0.88210291
113MP0002233_abnormal_nose_morphology0.87977372
114MP0003755_abnormal_palate_morphology0.87957002
115MP0002081_perinatal_lethality0.87774968
116MP0003937_abnormal_limbs/digits/tail_de0.87272131
117MP0006072_abnormal_retinal_apoptosis0.86990490
118MP0002932_abnormal_joint_morphology0.86858431
119MP0002909_abnormal_adrenal_gland0.86233199
120MP0001663_abnormal_digestive_system0.86152919
121MP0001905_abnormal_dopamine_level0.84744483
122MP0001697_abnormal_embryo_size0.84730606
123MP0001727_abnormal_embryo_implantation0.84676016
124MP0000681_abnormal_thyroid_gland0.82619509
125MP0003763_abnormal_thymus_physiology0.81836307
126MP0003880_abnormal_central_pattern0.81366036
127MP0001986_abnormal_taste_sensitivity0.81167145
128MP0002084_abnormal_developmental_patter0.81138237
129MP0002069_abnormal_eating/drinking_beha0.80084917
130MP0004147_increased_porphyrin_level0.79943682
131MP0003698_abnormal_male_reproductive0.79269909
132MP0005195_abnormal_posterior_eye0.79164596
133MP0005381_digestive/alimentary_phenotyp0.78122408
134MP0001919_abnormal_reproductive_system0.76945154
135MP0003186_abnormal_redox_activity0.76741070
136MP0000647_abnormal_sebaceous_gland0.76339963
137MP0002116_abnormal_craniofacial_bone0.74525897
138MP0002095_abnormal_skin_pigmentation0.74384256
139MP0002177_abnormal_outer_ear0.72739157
140MP0000372_irregular_coat_pigmentation0.71255723
141MP0009333_abnormal_splenocyte_physiolog0.71213881
142MP0002557_abnormal_social/conspecific_i0.70695850
143MP0002210_abnormal_sex_determination0.70148636
144MP0002152_abnormal_brain_morphology0.67703339
145MP0002277_abnormal_respiratory_mucosa0.66974080
146MP0009053_abnormal_anal_canal0.64322010
147MP0002398_abnormal_bone_marrow0.61832727

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.90075179
2Abnormality of cells of the erythroid lineage (HP:0012130)4.88968678
3Aplastic anemia (HP:0001915)4.64017356
4Abnormal number of erythroid precursors (HP:0012131)4.50488830
5Rectal prolapse (HP:0002035)4.50455093
6Abnormality of the fingertips (HP:0001211)4.28010154
7Hypochromic anemia (HP:0001931)4.09308581
8Abnormality of the labia minora (HP:0012880)3.89264733
9Gastrointestinal infarctions (HP:0005244)3.82962789
10Neoplasm of head and neck (HP:0012288)3.57925931
11Esophageal neoplasm (HP:0100751)3.57925931
12Morphological abnormality of the middle ear (HP:0008609)3.45999465
13Nasal polyposis (HP:0100582)3.34993087
14Patellar aplasia (HP:0006443)3.29294155
15Retinal dysplasia (HP:0007973)3.20076757
16Biliary tract neoplasm (HP:0100574)3.18553615
17Pallor (HP:0000980)3.16987741
18Aplasia/Hypoplasia of the patella (HP:0006498)3.14408228
19Cortical dysplasia (HP:0002539)3.12967748
20Hepatic necrosis (HP:0002605)3.08399318
21Abnormality of nail color (HP:0100643)3.05878235
22Macrocytic anemia (HP:0001972)3.03162724
23Limb dystonia (HP:0002451)3.01874467
24Abnormal number of incisors (HP:0011064)3.01349045
25Polyphagia (HP:0002591)3.00341542
26Breast carcinoma (HP:0003002)2.89502919
27Germ cell neoplasia (HP:0100728)2.81943394
28Gait imbalance (HP:0002141)2.72349655
29Optic disc pallor (HP:0000543)2.69688360
30Abnormality of the intervertebral disk (HP:0005108)2.65857905
31Acute necrotizing encephalopathy (HP:0006965)2.60633461
32Mitochondrial inheritance (HP:0001427)2.58566121
33Increased hepatocellular lipid droplets (HP:0006565)2.57993810
34Medial flaring of the eyebrow (HP:0010747)2.55172358
35Testicular neoplasm (HP:0010788)2.53758335
36Pendular nystagmus (HP:0012043)2.52777822
37Neoplasm of the rectum (HP:0100743)2.52438261
38Abnormality of the nasal mucosa (HP:0000433)2.51854249
39Pachygyria (HP:0001302)2.50746068
40True hermaphroditism (HP:0010459)2.50578352
4111 pairs of ribs (HP:0000878)2.43843211
42Gonadal dysgenesis (HP:0000133)2.42501044
43Lipid accumulation in hepatocytes (HP:0006561)2.41330598
44Congenital primary aphakia (HP:0007707)2.40882494
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37792427
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37792427
47Nephrogenic diabetes insipidus (HP:0009806)2.37585981
48Occipital encephalocele (HP:0002085)2.37112140
49Colon cancer (HP:0003003)2.35024357
50Hypoplasia of the brainstem (HP:0002365)2.35015482
51Aplasia/Hypoplasia of the brainstem (HP:0007362)2.35015482
52Depressed nasal ridge (HP:0000457)2.34788871
53Molar tooth sign on MRI (HP:0002419)2.33765066
54Abnormality of midbrain morphology (HP:0002418)2.33765066
55Optic nerve coloboma (HP:0000588)2.33721913
56Agammaglobulinemia (HP:0004432)2.33652124
57Myokymia (HP:0002411)2.32899454
58Cerebral edema (HP:0002181)2.32645477
59Severe visual impairment (HP:0001141)2.30980368
60Hypoplastic pelvis (HP:0008839)2.30908233
61Failure to thrive in infancy (HP:0001531)2.29897373
62Abnormal mitochondria in muscle tissue (HP:0008316)2.27473623
63Large eyes (HP:0001090)2.24855856
64Hyperacusis (HP:0010780)2.24405834
65Neoplasm of the pancreas (HP:0002894)2.24159661
66Embryonal neoplasm (HP:0002898)2.22549846
67Renal Fanconi syndrome (HP:0001994)2.18857365
68Increased serum lactate (HP:0002151)2.18218856
69Pancreatic cysts (HP:0001737)2.17795386
70Neoplasm of the small intestine (HP:0100833)2.14806948
71Hyperglycinemia (HP:0002154)2.13252895
72Broad-based gait (HP:0002136)2.11624984
73Neoplasm of the colon (HP:0100273)2.10772510
743-Methylglutaconic aciduria (HP:0003535)2.09718430
75Lactic acidosis (HP:0003128)2.06663121
76Abnormality of B cell number (HP:0010975)2.04908487
77B lymphocytopenia (HP:0010976)2.04908487
78Lissencephaly (HP:0001339)2.03828397
79Thick lower lip vermilion (HP:0000179)2.01853717
80Increased intramyocellular lipid droplets (HP:0012240)2.00268217
81Pancreatic fibrosis (HP:0100732)1.99102290
82Methylmalonic acidemia (HP:0002912)1.98185653
83Vaginal atresia (HP:0000148)1.96904204
84Nephronophthisis (HP:0000090)1.96579110
85Natal tooth (HP:0000695)1.95908959
86Hypsarrhythmia (HP:0002521)1.95571427
87Specific learning disability (HP:0001328)1.95459608
88Type II lissencephaly (HP:0007260)1.94951250
89Genital tract atresia (HP:0001827)1.94858768
90Drooling (HP:0002307)1.94397684
91Broad alveolar ridges (HP:0000187)1.94006324
92Progressive macrocephaly (HP:0004481)1.92852410
93Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92444334
94Slow-growing hair (HP:0002217)1.91936638
95Abnormality of hair growth rate (HP:0011363)1.91936638
96Sclerocornea (HP:0000647)1.91862761
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.91502057
98Renal duplication (HP:0000075)1.89245983
99Cerebral hypomyelination (HP:0006808)1.88984862
100Spastic tetraplegia (HP:0002510)1.87635532
101Oral leukoplakia (HP:0002745)1.85252247
102Fibular aplasia (HP:0002990)1.85095084
103Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84302709
104Facial cleft (HP:0002006)1.82529973
105Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81517146
106EEG with generalized epileptiform discharges (HP:0011198)1.81214161
107Methylmalonic aciduria (HP:0012120)1.80008441
108Agitation (HP:0000713)1.78238502
109Tapered finger (HP:0001182)1.78226296
110Amblyopia (HP:0000646)1.77883250
111Microvesicular hepatic steatosis (HP:0001414)1.77772914
112Abnormality of the corticospinal tract (HP:0002492)1.77660127
113Emotional lability (HP:0000712)1.76554644
114Degeneration of anterior horn cells (HP:0002398)1.76119154
115Abnormality of the anterior horn cell (HP:0006802)1.76119154
116Epileptiform EEG discharges (HP:0011182)1.75816172
117Respiratory failure (HP:0002878)1.75735207
118Leukodystrophy (HP:0002415)1.75463102
119Exercise intolerance (HP:0003546)1.75353999
120Abnormality of the heme biosynthetic pathway (HP:0010472)1.75095256
121Esotropia (HP:0000565)1.74145516
122X-linked dominant inheritance (HP:0001423)1.73871785
123Anencephaly (HP:0002323)1.73668482
124Urinary urgency (HP:0000012)1.73251156
125Increased CSF lactate (HP:0002490)1.73090275
126Precocious puberty (HP:0000826)1.73045381
127Poor suck (HP:0002033)1.71710766
128Scrotal hypoplasia (HP:0000046)1.70815503
129Amyotrophic lateral sclerosis (HP:0007354)1.70214655
130Preaxial hand polydactyly (HP:0001177)1.69967079
131Acute lymphatic leukemia (HP:0006721)1.69761965
132Abnormal hair whorl (HP:0010721)1.69079460
133Medulloblastoma (HP:0002885)1.68873648
134Horseshoe kidney (HP:0000085)1.68868281
135Shoulder girdle muscle weakness (HP:0003547)1.68804262
136Renal hypoplasia (HP:0000089)1.68802795
137Excessive salivation (HP:0003781)1.68179404
138Asymmetry of the thorax (HP:0001555)1.68138919
139Anophthalmia (HP:0000528)1.68092858
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.67908777
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.67908777
142Polymicrogyria (HP:0002126)1.66539013
143Decreased testicular size (HP:0008734)1.66506048
144Rough bone trabeculation (HP:0100670)1.65809795
145Thyroid-stimulating hormone excess (HP:0002925)1.65781775
146Aplasia/hypoplasia of the uterus (HP:0008684)1.65529479
147Muscular hypotonia of the trunk (HP:0008936)1.64713219
148Split foot (HP:0001839)1.64578215
149Narrow forehead (HP:0000341)1.64113221
150Tented upper lip vermilion (HP:0010804)1.63625481
151Abnormality of the metopic suture (HP:0005556)1.63413778
152Triphalangeal thumb (HP:0001199)1.63326423
153Septo-optic dysplasia (HP:0100842)1.62705569
154Oligodactyly (hands) (HP:0001180)1.61404518
155Microretrognathia (HP:0000308)1.59967426
156Abnormal biliary tract morphology (HP:0012440)1.57862874
157Overlapping toe (HP:0001845)1.57149745
158Gastrointestinal carcinoma (HP:0002672)1.57039742
159Malignant gastrointestinal tract tumors (HP:0006749)1.57039742
160Uterine neoplasm (HP:0010784)1.56820369
161Selective tooth agenesis (HP:0001592)1.56100967
162Absent thumb (HP:0009777)1.53974721
163Hypothermia (HP:0002045)1.53383233
164Abnormality of abdominal situs (HP:0011620)1.52656776
165Abdominal situs inversus (HP:0003363)1.52656776
166Hepatocellular necrosis (HP:0001404)1.52539787
167Ovarian neoplasm (HP:0100615)1.51475756
168High anterior hairline (HP:0009890)1.51157983
169Congenital diaphragmatic hernia (HP:0000776)1.51069637
170Thrombocytosis (HP:0001894)1.50432507
171Acute encephalopathy (HP:0006846)1.50387621
172Abnormality of the ileum (HP:0001549)1.49724515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.34770663
2MAP3K123.78366296
3TAOK23.66336786
4TLK13.62912607
5MARK13.32023479
6MAP2K73.30419325
7MAP3K42.98115540
8VRK22.72334985
9SRPK12.65682313
10DYRK22.65133801
11MAP4K22.50478967
12DYRK32.49461865
13TRIM282.40603971
14STK162.35256444
15LIMK12.22399270
16BUB12.08797793
17BCKDK2.05956134
18MAP3K101.90958562
19MYLK1.86503269
20MAPK131.79162212
21RPS6KA21.76683971
22EIF2AK11.72973108
23SIK21.67703790
24ERBB31.65995194
25WEE11.65173648
26SIK31.63113522
27CCNB11.62452666
28PAK41.53343076
29PRPF4B1.52841765
30MKNK11.52013529
31ZAK1.49724650
32RPS6KA51.41628742
33MAP2K41.36809858
34UHMK11.35777208
35DAPK31.33666551
36RPS6KC11.32659810
37RPS6KL11.32659810
38TGFBR11.25586408
39EPHB21.25465817
40ACVR1B1.24639451
41PINK11.20557817
42DAPK11.16903078
43RPS6KA61.16649548
44DYRK1B1.14956373
45PIM21.14623190
46VRK11.13992387
47PASK1.13623701
48MKNK21.09485120
49MAP2K61.03672765
50CSNK1G31.02768208
51RPS6KB21.02581067
52PRKCG0.98055374
53CLK10.97170092
54NEK10.96774866
55ILK0.94025756
56NTRK20.92351646
57TSSK60.92321045
58EPHA40.92000677
59AURKA0.91828389
60PRKD30.89967673
61CDK140.89743801
62AURKB0.89441686
63TESK10.89318530
64YES10.89182035
65PAK30.87482143
66LRRK20.85702305
67NME10.85085119
68PHKG20.84752381
69PHKG10.84752381
70PLK40.84536316
71PLK30.83471225
72CDK190.80779982
73TESK20.78513276
74PBK0.77351028
75NUAK10.77019779
76PLK10.75469053
77MINK10.74169050
78BMPR1B0.73898898
79MAPK40.72005542
80INSRR0.69336670
81CDC70.68109752
82MATK0.67923195
83RPS6KA40.67807131
84CASK0.67680829
85CDK50.67159085
86KIT0.64585417
87ATR0.64031177
88PNCK0.63811065
89NEK20.62511448
90MAP3K110.62466715
91PAK60.61530883
92CDK70.58602928
93KSR10.58401973
94PAK10.57725041
95TNIK0.57207509
96SYK0.56817510
97CSNK1G20.56435888
98CSNK1E0.55246841
99BRAF0.54051601
100CHEK20.53669397
101TAF10.53212261
102PKN10.52950530
103CSNK1G10.51712720
104PLK20.50398208
105EIF2AK20.49900364
106DYRK1A0.49744422
107CDK180.49719065
108RPS6KB10.49399958
109CAMK2B0.48366218
110GRK10.48305021
111PRKCE0.48184552
112CSF1R0.47367122
113CSNK1A1L0.47360903
114IRAK40.46750562
115WNK40.46315806
116CDK11A0.46266593
117CAMK40.46204850
118RPS6KA10.45687830
119PRKCZ0.44868645
120CSNK1A10.44799394
121CAMK2A0.44346094
122MAP3K80.44038590
123CDK80.43908373
124ROCK10.43141499
125BCR0.42849759
126CSNK2A10.42069237
127STK110.41570817
128BTK0.41018936
129CDK150.40487900
130TTK0.40177043
131CSNK2A20.39467170
132ADRBK20.38724802
133HIPK20.38546461
134ABL20.38483119
135MAP3K60.37639859
136MAPK90.37584170
137PRKCI0.36966908
138ATM0.36619012
139GRK60.36246424
140CAMK2G0.35359046
141BRSK10.33270286
142WNK30.32571584

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.70284053
2DNA replication_Homo sapiens_hsa030303.56163089
3Parkinsons disease_Homo sapiens_hsa050123.05960348
4Spliceosome_Homo sapiens_hsa030403.03055991
5Proteasome_Homo sapiens_hsa030503.00414655
6Mismatch repair_Homo sapiens_hsa034302.98823814
7Oxidative phosphorylation_Homo sapiens_hsa001902.96191478
8Base excision repair_Homo sapiens_hsa034102.77381114
9RNA polymerase_Homo sapiens_hsa030202.61539645
10Nicotine addiction_Homo sapiens_hsa050332.30535159
11Huntingtons disease_Homo sapiens_hsa050162.30453376
12Pyrimidine metabolism_Homo sapiens_hsa002402.16363324
13Nucleotide excision repair_Homo sapiens_hsa034202.14888151
14Cell cycle_Homo sapiens_hsa041102.08544481
15Alzheimers disease_Homo sapiens_hsa050102.02355542
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01160655
17Steroid biosynthesis_Homo sapiens_hsa001001.98365755
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81148973
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76673582
20RNA transport_Homo sapiens_hsa030131.68671180
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63593810
22Homologous recombination_Homo sapiens_hsa034401.55098522
23Synaptic vesicle cycle_Homo sapiens_hsa047211.54794401
24Phototransduction_Homo sapiens_hsa047441.51778922
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.48035202
26Collecting duct acid secretion_Homo sapiens_hsa049661.35717402
27Alcoholism_Homo sapiens_hsa050341.32353288
28Fatty acid elongation_Homo sapiens_hsa000621.30806465
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29367764
30Cardiac muscle contraction_Homo sapiens_hsa042601.27877248
31Non-homologous end-joining_Homo sapiens_hsa034501.27768418
32Notch signaling pathway_Homo sapiens_hsa043301.26512877
33Systemic lupus erythematosus_Homo sapiens_hsa053221.25816534
34Protein export_Homo sapiens_hsa030601.24477142
35Hedgehog signaling pathway_Homo sapiens_hsa043401.21665600
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21476925
37GABAergic synapse_Homo sapiens_hsa047271.21223903
38mRNA surveillance pathway_Homo sapiens_hsa030151.19416126
39Butanoate metabolism_Homo sapiens_hsa006501.17894103
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16159128
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14578124
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14244133
43Basal cell carcinoma_Homo sapiens_hsa052171.13525868
44Fanconi anemia pathway_Homo sapiens_hsa034601.13107706
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09955369
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09153772
47Epstein-Barr virus infection_Homo sapiens_hsa051691.08790185
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07419144
49Folate biosynthesis_Homo sapiens_hsa007901.07245505
50p53 signaling pathway_Homo sapiens_hsa041151.03776973
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00774294
52RNA degradation_Homo sapiens_hsa030180.99689709
53Basal transcription factors_Homo sapiens_hsa030220.97997676
54Selenocompound metabolism_Homo sapiens_hsa004500.96296141
55Primary immunodeficiency_Homo sapiens_hsa053400.92297911
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91833197
57Purine metabolism_Homo sapiens_hsa002300.91351758
58Propanoate metabolism_Homo sapiens_hsa006400.90697968
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89168314
60Pyruvate metabolism_Homo sapiens_hsa006200.88938182
61Biosynthesis of amino acids_Homo sapiens_hsa012300.88245907
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.87662481
63Morphine addiction_Homo sapiens_hsa050320.86615212
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86534008
65N-Glycan biosynthesis_Homo sapiens_hsa005100.83217883
66Taste transduction_Homo sapiens_hsa047420.82485798
67Cocaine addiction_Homo sapiens_hsa050300.81221229
68* Metabolic pathways_Homo sapiens_hsa011000.77541345
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77401953
70Colorectal cancer_Homo sapiens_hsa052100.77199261
71Thyroid cancer_Homo sapiens_hsa052160.76177233
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75994623
73Chronic myeloid leukemia_Homo sapiens_hsa052200.75900692
74Peroxisome_Homo sapiens_hsa041460.74541393
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72944669
76Sulfur metabolism_Homo sapiens_hsa009200.65583565
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.65233245
78Axon guidance_Homo sapiens_hsa043600.62602325
79Viral carcinogenesis_Homo sapiens_hsa052030.60915494
80HTLV-I infection_Homo sapiens_hsa051660.60762465
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60648104
82Pathways in cancer_Homo sapiens_hsa052000.60023115
83Glutamatergic synapse_Homo sapiens_hsa047240.59323218
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58972860
85Regulation of autophagy_Homo sapiens_hsa041400.58306428
86Carbon metabolism_Homo sapiens_hsa012000.56519862
87Sulfur relay system_Homo sapiens_hsa041220.54794981
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53097869
89Wnt signaling pathway_Homo sapiens_hsa043100.51929360
90Herpes simplex infection_Homo sapiens_hsa051680.51911731
91Circadian entrainment_Homo sapiens_hsa047130.51900357
92B cell receptor signaling pathway_Homo sapiens_hsa046620.51810208
93Glutathione metabolism_Homo sapiens_hsa004800.51456606
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50433857
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49136648
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48699376
97Small cell lung cancer_Homo sapiens_hsa052220.48484435
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47102235
99Serotonergic synapse_Homo sapiens_hsa047260.46585332
100Olfactory transduction_Homo sapiens_hsa047400.45898128
101One carbon pool by folate_Homo sapiens_hsa006700.45776095
102Arginine and proline metabolism_Homo sapiens_hsa003300.45532687
103Allograft rejection_Homo sapiens_hsa053300.44966486
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44728500
105Asthma_Homo sapiens_hsa053100.43915842
106MicroRNAs in cancer_Homo sapiens_hsa052060.43631388
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43429640
108beta-Alanine metabolism_Homo sapiens_hsa004100.42911346
109Viral myocarditis_Homo sapiens_hsa054160.42570469
110Amphetamine addiction_Homo sapiens_hsa050310.42525204
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42291113
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41443879
113Fatty acid metabolism_Homo sapiens_hsa012120.41279895
114Bladder cancer_Homo sapiens_hsa052190.41263968
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40349868
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39276550
117Vitamin B6 metabolism_Homo sapiens_hsa007500.39095169
118Hippo signaling pathway_Homo sapiens_hsa043900.38302402
119Oocyte meiosis_Homo sapiens_hsa041140.38211256
120Apoptosis_Homo sapiens_hsa042100.37573396
121Endometrial cancer_Homo sapiens_hsa052130.36530097
122Non-small cell lung cancer_Homo sapiens_hsa052230.35893677
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34728087
124Tryptophan metabolism_Homo sapiens_hsa003800.33150373
125Type I diabetes mellitus_Homo sapiens_hsa049400.32448331
126FoxO signaling pathway_Homo sapiens_hsa040680.31628278
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30549573
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.29810902
129Tyrosine metabolism_Homo sapiens_hsa003500.28064133
130Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28043978
131Shigellosis_Homo sapiens_hsa051310.27801212
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.26225600
133Gap junction_Homo sapiens_hsa045400.25284235
134Maturity onset diabetes of the young_Homo sapiens_hsa049500.25104179
135Hepatitis B_Homo sapiens_hsa051610.25039804
136Dopaminergic synapse_Homo sapiens_hsa047280.24102109
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23035148
138Leishmaniasis_Homo sapiens_hsa051400.22830098
139Influenza A_Homo sapiens_hsa051640.22779770
140Vibrio cholerae infection_Homo sapiens_hsa051100.22462361
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21498434
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21459201
143Pancreatic cancer_Homo sapiens_hsa052120.21176412
144Hematopoietic cell lineage_Homo sapiens_hsa046400.20941096
145Renal cell carcinoma_Homo sapiens_hsa052110.20796504
146Cholinergic synapse_Homo sapiens_hsa047250.20257074
147HIF-1 signaling pathway_Homo sapiens_hsa040660.20125198
148Galactose metabolism_Homo sapiens_hsa000520.17784491
149Acute myeloid leukemia_Homo sapiens_hsa052210.17508007
150Antigen processing and presentation_Homo sapiens_hsa046120.17471243
151Neurotrophin signaling pathway_Homo sapiens_hsa047220.17247613
152Melanogenesis_Homo sapiens_hsa049160.16098740

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