PAG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.18543678
2negative regulation of cell killing (GO:0031342)5.88481542
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.88481542
4positive regulation by symbiont of host defense response (GO:0052509)5.26908221
5modulation by symbiont of host defense response (GO:0052031)5.26908221
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26908221
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26908221
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.26908221
9modulation by symbiont of host immune response (GO:0052553)5.26908221
10positive regulation of gamma-delta T cell activation (GO:0046645)5.12579948
11microglial cell activation (GO:0001774)5.00794623
12regulation of B cell receptor signaling pathway (GO:0050855)4.95626313
13regulation of interferon-beta biosynthetic process (GO:0045357)4.89518437
14cellular extravasation (GO:0045123)4.72085881
15activated T cell proliferation (GO:0050798)4.63173284
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.61733720
17macrophage activation involved in immune response (GO:0002281)4.43785223
18negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.42529745
19negative regulation of translation, ncRNA-mediated (GO:0040033)4.42529745
20regulation of translation, ncRNA-mediated (GO:0045974)4.42529745
21regulation of gamma-delta T cell differentiation (GO:0045586)4.35752769
22positive thymic T cell selection (GO:0045059)4.21113625
23T cell migration (GO:0072678)4.10141931
24germ cell migration (GO:0008354)4.08846671
25positive T cell selection (GO:0043368)4.07113844
26B cell receptor signaling pathway (GO:0050853)4.04261974
27regulation of gamma-delta T cell activation (GO:0046643)3.97983405
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.95233340
29negative regulation of T cell mediated immunity (GO:0002710)3.91799065
30regulation of regulatory T cell differentiation (GO:0045589)3.70979679
31positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67570838
32response to host (GO:0075136)3.65115116
33response to host defenses (GO:0052200)3.65115116
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65115116
35negative T cell selection (GO:0043383)3.64663502
36response to host immune response (GO:0052572)3.63570501
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.63570501
38regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.63450346
39positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.63450346
40RNA destabilization (GO:0050779)3.61980309
41regulation of alpha-beta T cell proliferation (GO:0046640)3.59827158
42positive regulation of B cell differentiation (GO:0045579)3.59805297
43negative regulation of lymphocyte mediated immunity (GO:0002707)3.53842541
44positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.51844390
45regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.51844390
46negative regulation of granulocyte differentiation (GO:0030853)3.51789291
47leukocyte aggregation (GO:0070486)3.49312931
48B cell homeostasis (GO:0001782)3.47104240
49B cell proliferation (GO:0042100)3.45651093
50tolerance induction (GO:0002507)3.45444068
51response to cholesterol (GO:0070723)3.44214097
52positive regulation of Rap GTPase activity (GO:0032854)3.43549951
53I-kappaB phosphorylation (GO:0007252)3.42803902
54negative thymic T cell selection (GO:0045060)3.34095213
55germinal center formation (GO:0002467)3.33958863
56T cell selection (GO:0045058)3.33405151
57G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.32694844
58natural killer cell differentiation (GO:0001779)3.32208259
59thymic T cell selection (GO:0045061)3.31174388
60regulation of B cell differentiation (GO:0045577)3.28453209
61positive regulation of tolerance induction (GO:0002645)3.23427948
62positive regulation of chemokine secretion (GO:0090197)3.23366671
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.19659934
64positive regulation of mRNA catabolic process (GO:0061014)3.19232294
65regulation of tolerance induction (GO:0002643)3.17998663
66interferon-gamma production (GO:0032609)3.15010157
67regulation of isotype switching to IgG isotypes (GO:0048302)3.12847719
68negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11835327
69positive regulation of alpha-beta T cell proliferation (GO:0046641)3.11334232
70mature B cell differentiation (GO:0002335)3.09758172
71phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.08911657
72negative regulation of leukocyte mediated immunity (GO:0002704)3.08699860
73* antigen receptor-mediated signaling pathway (GO:0050851)3.06639729
74response to interleukin-15 (GO:0070672)3.04330105
75negative regulation of T-helper cell differentiation (GO:0045623)3.03698590
76negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03698590
77macrophage activation (GO:0042116)3.02837055
78G-protein coupled receptor internalization (GO:0002031)3.02360472
79response to sterol (GO:0036314)3.01346679
80regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.00456396
81dendritic cell migration (GO:0036336)2.99719510
82pathway-restricted SMAD protein phosphorylation (GO:0060389)2.99625182
83T cell homeostasis (GO:0043029)2.99183136
84antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98411626
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98411626
86cellular response to ethanol (GO:0071361)2.98339090
87detection of other organism (GO:0098543)2.98256128
88response to type I interferon (GO:0034340)2.97482285
89cellular response to type I interferon (GO:0071357)2.97475421
90type I interferon signaling pathway (GO:0060337)2.97475421
91regulation of T cell mediated cytotoxicity (GO:0001914)2.96842130
92regulation of mRNA catabolic process (GO:0061013)2.94828503
93positive regulation of interferon-alpha production (GO:0032727)2.93444057
94negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.93232439
95negative regulation of adaptive immune response (GO:0002820)2.93078231
96myeloid cell activation involved in immune response (GO:0002275)2.91831645
97negative regulation of B cell proliferation (GO:0030889)2.91477786
98purinergic nucleotide receptor signaling pathway (GO:0035590)2.90748772
99lymphocyte homeostasis (GO:0002260)2.90530595
100regulation of Rap GTPase activity (GO:0032317)2.89364998
101cellular response to interleukin-15 (GO:0071350)2.86189237
102positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.84234254
103regulation of germinal center formation (GO:0002634)2.83694877
104alpha-beta T cell differentiation (GO:0046632)2.82689713
105regulation of T cell tolerance induction (GO:0002664)2.81483714
106regulation of interleukin-2 biosynthetic process (GO:0045076)2.80243057
107* T cell receptor signaling pathway (GO:0050852)2.79372017
108detection of bacterium (GO:0016045)2.79259896
109regulation of alpha-beta T cell activation (GO:0046634)2.79117759
110monocyte differentiation (GO:0030224)2.78927773
111antigen processing and presentation of endogenous antigen (GO:0019883)2.78074763
112histone H3-K4 trimethylation (GO:0080182)2.77921334
113negative regulation of interleukin-12 production (GO:0032695)2.76801842
114immunoglobulin mediated immune response (GO:0016064)2.75381041
115negative regulation of bone resorption (GO:0045779)2.75333064
116adaptation of signaling pathway (GO:0023058)2.75251624
117detection of molecule of bacterial origin (GO:0032490)2.74757433
118interferon-gamma-mediated signaling pathway (GO:0060333)2.74463012
119regulation of interferon-alpha production (GO:0032647)2.74322011
120pyrimidine ribonucleoside catabolic process (GO:0046133)2.73745946
121regulation of granulocyte differentiation (GO:0030852)2.72865127
122myeloid leukocyte mediated immunity (GO:0002444)2.72152347
123mast cell activation (GO:0045576)2.71996599
124hepatocyte apoptotic process (GO:0097284)2.71309594
125cytidine deamination (GO:0009972)2.70014744
126cytidine metabolic process (GO:0046087)2.70014744
127cytidine catabolic process (GO:0006216)2.70014744
128dendritic cell chemotaxis (GO:0002407)2.69598874
129antigen processing and presentation via MHC class Ib (GO:0002475)2.69532385
130regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.67780537
131regulation of natural killer cell mediated immunity (GO:0002715)2.67780537
132negative regulation of phagocytosis (GO:0050765)2.67486733
133neutrophil mediated immunity (GO:0002446)2.67368969
134positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67061232
135detection of external biotic stimulus (GO:0098581)2.66287754
136Peyers patch development (GO:0048541)2.65970350
137mucosal-associated lymphoid tissue development (GO:0048537)2.65970350
138regulation of interleukin-12 biosynthetic process (GO:0045075)2.65191682
139negative regulation of alpha-beta T cell activation (GO:0046636)2.65115613
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63697128
141neutrophil activation (GO:0042119)2.63321429
142negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.60950058
143alpha-beta T cell activation (GO:0046631)2.60627106
144leukocyte cell-cell adhesion (GO:0007159)2.60012029
145regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.59708662
146T cell costimulation (GO:0031295)2.59300108
1473-UTR-mediated mRNA stabilization (GO:0070935)2.58596010
148regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58169835
149positive regulation of granulocyte differentiation (GO:0030854)2.58046228
150cellular defense response (GO:0006968)2.57660549
151mononuclear cell proliferation (GO:0032943)2.57468371
152regulation of B cell proliferation (GO:0030888)2.53432856

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.98584260
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.88700996
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.44539911
4* IRF8_27001747_Chip-Seq_BMDM_Mouse3.39089058
5* RUNX_20019798_ChIP-Seq_JUKART_Human3.32268115
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.30592465
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.25157600
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.16440327
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.15660948
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.08634211
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01490724
12SCL_19346495_ChIP-Seq_HPC-7_Human2.92989472
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.87879384
14* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.77975948
15MYC_22102868_ChIP-Seq_BL_Human2.74530496
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73544466
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.68110436
18MYB_26560356_Chip-Seq_TH2_Human2.40727567
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.38712089
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.29918636
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29648647
22GATA1_22025678_ChIP-Seq_K562_Human2.27756923
23TCF7_22412390_ChIP-Seq_EML_Mouse2.18825848
24VDR_21846776_ChIP-Seq_THP-1_Human2.11429721
25SPI1_23127762_ChIP-Seq_K562_Human2.06054409
26EZH2_22144423_ChIP-Seq_EOC_Human2.05630273
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.05316635
28MAF_26560356_Chip-Seq_TH1_Human2.02273605
29MYB_26560356_Chip-Seq_TH1_Human1.96916743
30* UTX_26944678_Chip-Seq_JUKART_Human1.94718647
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93187213
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.91107563
33VDR_24763502_ChIP-Seq_THP-1_Human1.90429857
34GATA3_27048872_Chip-Seq_THYMUS_Human1.84175066
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.83628345
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79870307
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79642299
38KDM2B_26808549_Chip-Seq_DND41_Human1.74057554
39* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68907196
40SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67303890
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.63754258
42VDR_24787735_ChIP-Seq_THP-1_Human1.59420136
43PU_27001747_Chip-Seq_BMDM_Mouse1.56427614
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55086314
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49365468
46SPI1_23547873_ChIP-Seq_NB4_Human1.48185367
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48179429
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45315343
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44415365
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.41687242
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36761658
52NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34715057
53TP53_16413492_ChIP-PET_HCT116_Human1.26100499
54* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25866512
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25122968
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.24026998
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22644735
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.22366695
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.22168209
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.20418495
61GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18992180
62PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17289406
63GATA2_19941826_ChIP-Seq_K562_Human1.16690291
64RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15741339
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14722007
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11818022
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11107788
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11080134
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10718847
70* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09058548
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08919894
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08859834
73GATA3_26560356_Chip-Seq_TH2_Human1.06617370
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05901274
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05425649
76BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05047989
77GATA1_19941826_ChIP-Seq_K562_Human1.03998194
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02795747
79* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01909932
80RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00707465
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.99619284
82ER_23166858_ChIP-Seq_MCF-7_Human0.99452788
83SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99325460
84PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98678278
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.98249616
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98029671
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.97779358
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95647086
89PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94294066
90* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93789903
91MAF_26560356_Chip-Seq_TH2_Human0.93731943
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92864884
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92402932
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.92119260
95TAF15_26573619_Chip-Seq_HEK293_Human0.92098543
96DROSHA_22980978_ChIP-Seq_HELA_Human0.91497730
97SMRT_27268052_Chip-Seq_Bcells_Human0.91187045
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90774530
99OCT4_21477851_ChIP-Seq_ESCs_Mouse0.89265943
100BCAT_22108803_ChIP-Seq_LS180_Human0.89079576
101SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88507749
102GATA2_22383799_ChIP-Seq_G1ME_Mouse0.87042323
103FLI1_21867929_ChIP-Seq_TH2_Mouse0.86574115
104AR_21572438_ChIP-Seq_LNCaP_Human0.85178181
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.84601325
106GBX2_23144817_ChIP-Seq_PC3_Human0.84561563
107STAT3_23295773_ChIP-Seq_U87_Human0.84326394
108GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82184689
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82052422
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.81674919
111CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81174242
112CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80613386
113* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.80465902
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79937900
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79937900
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.79430088
117FOXM1_23109430_ChIP-Seq_U2OS_Human0.78852504
118* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78777341
119VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77731194
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77315855
121* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.76762022
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.76721166
123FOXO3_23340844_ChIP-Seq_DLD1_Human0.76613973
124NFIB_24661679_ChIP-Seq_LUNG_Mouse0.76550739
125KDM2B_26808549_Chip-Seq_K562_Human0.75561130
126TCF4_18268006_ChIP-ChIP_LS174T_Human0.74318199
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73443110
128ZFP281_27345836_Chip-Seq_ESCs_Mouse0.72408657
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72210418
130STAT6_21828071_ChIP-Seq_BEAS2B_Human0.71617627
131GATA3_26560356_Chip-Seq_TH1_Human0.71367187
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.69813046
133* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.69512537
134TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.68785705
135RXR_22108803_ChIP-Seq_LS180_Human0.68496807
136* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.66994614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.93665480
2MP0005671_abnormal_response_to3.90332207
3MP0001835_abnormal_antigen_presentation3.17068686
4MP0002396_abnormal_hematopoietic_system2.99312102
5MP0001800_abnormal_humoral_immune2.99053255
6MP0003300_gastrointestinal_ulcer2.86223894
7MP0003303_peritoneal_inflammation2.83565039
8MP0006082_CNS_inflammation2.83324794
9MP0002452_abnormal_antigen_presenting2.70631528
10MP0005464_abnormal_platelet_physiology2.70432304
11MP0003763_abnormal_thymus_physiology2.66857029
12MP0001790_abnormal_immune_system2.61620951
13MP0005387_immune_system_phenotype2.61620951
14MP0002723_abnormal_immune_serum2.54255939
15MP0003172_abnormal_lysosome_physiology2.52304103
16MP0002419_abnormal_innate_immunity2.49826190
17MP0002009_preneoplasia2.49398778
18MP0001819_abnormal_immune_cell2.47817796
19MP0002420_abnormal_adaptive_immunity2.47622994
20MP0005000_abnormal_immune_tolerance2.46647893
21MP0000569_abnormal_digit_pigmentation2.43736421
22MP0000685_abnormal_immune_system2.35661898
23MP0003436_decreased_susceptibility_to2.31922173
24MP0001853_heart_inflammation2.30815140
25MP0004381_abnormal_hair_follicle2.27170336
26* MP0002398_abnormal_bone_marrow2.24169032
27MP0001851_eye_inflammation2.23216563
28* MP0000716_abnormal_immune_system2.08850309
29MP0002166_altered_tumor_susceptibility1.96860799
30MP0004947_skin_inflammation1.96634039
31MP0009278_abnormal_bone_marrow1.94557105
32MP0002148_abnormal_hypersensitivity_rea1.93918743
33MP0005025_abnormal_response_to1.93214255
34MP0004808_abnormal_hematopoietic_stem1.86513331
35MP0003183_abnormal_peptide_metabolism1.83687781
36* MP0000703_abnormal_thymus_morphology1.82626050
37MP0004510_myositis1.81749599
38MP0000689_abnormal_spleen_morphology1.81465272
39MP0002722_abnormal_immune_system1.79577283
40MP0002405_respiratory_system_inflammati1.70896244
41MP0000372_irregular_coat_pigmentation1.68991780
42MP0002933_joint_inflammation1.68539204
43MP0001845_abnormal_inflammatory_respons1.67958711
44MP0003045_fibrosis1.64741572
45* MP0002429_abnormal_blood_cell1.62582890
46MP0003828_pulmonary_edema1.60377060
47MP0008260_abnormal_autophagy1.58070249
48MP0005058_abnormal_lysosome_morphology1.49687241
49MP0010155_abnormal_intestine_physiology1.49246268
50MP0002928_abnormal_bile_duct1.48005908
51MP0002006_tumorigenesis1.44626891
52MP0003075_altered_response_to1.44511203
53MP0001533_abnormal_skeleton_physiology1.42631802
54MP0001873_stomach_inflammation1.40492348
55MP0009785_altered_susceptibility_to1.38984400
56MP0003252_abnormal_bile_duct1.38311489
57MP0000465_gastrointestinal_hemorrhage1.34564281
58MP0009764_decreased_sensitivity_to1.34173767
59MP0008961_abnormal_basal_metabolism1.33245403
60MP0003724_increased_susceptibility_to1.30065813
61MP0001545_abnormal_hematopoietic_system1.27813361
62MP0005397_hematopoietic_system_phenotyp1.27813361
63MP0005310_abnormal_salivary_gland1.27633764
64MP0003690_abnormal_glial_cell1.27372646
65MP0002998_abnormal_bone_remodeling1.26767747
66MP0001986_abnormal_taste_sensitivity1.23971820
67MP0005409_darkened_coat_color1.22334707
68MP0003866_abnormal_defecation1.22301895
69MP0004130_abnormal_muscle_cell1.18895739
70MP0005166_decreased_susceptibility_to1.17294630
71MP0003646_muscle_fatigue1.16845298
72MP0005174_abnormal_tail_pigmentation1.16534563
73MP0002138_abnormal_hepatobiliary_system1.14296640
74MP0005076_abnormal_cell_differentiation1.13997435
75MP0003787_abnormal_imprinting1.13080571
76MP0009333_abnormal_splenocyte_physiolog1.08245307
77MP0002277_abnormal_respiratory_mucosa1.07436166
78MP0004185_abnormal_adipocyte_glucose1.07426094
79MP0008004_abnormal_stomach_pH1.05258058
80MP0008469_abnormal_protein_level1.03973528
81MP0005171_absent_coat_pigmentation1.01993800
82MP0004484_altered_response_of0.93558974
83MP0005164_abnormal_response_to0.93115887
84MP0000920_abnormal_myelination0.90231531
85MP0008877_abnormal_DNA_methylation0.89850130
86MP0005167_abnormal_blood-brain_barrier0.87112242
87MP0008874_decreased_physiological_sensi0.86793655
88MP0008057_abnormal_DNA_replication0.83209598
89MP0000604_amyloidosis0.81198444
90MP0003566_abnormal_cell_adhesion0.79951587
91MP0000767_abnormal_smooth_muscle0.79539607
92MP0005408_hypopigmentation0.76931538
93MP0003136_yellow_coat_color0.75817869
94MP0002090_abnormal_vision0.75697238
95MP0001663_abnormal_digestive_system0.74672482
96MP0001501_abnormal_sleep_pattern0.74287153
97MP0000343_altered_response_to0.71198599
98MP0000249_abnormal_blood_vessel0.71157385
99MP0000015_abnormal_ear_pigmentation0.71050140
100MP0003448_altered_tumor_morphology0.66912596
101MP0000858_altered_metastatic_potential0.64172365
102MP0001919_abnormal_reproductive_system0.63884239
103MP0005023_abnormal_wound_healing0.62815469
104MP0003091_abnormal_cell_migration0.61252462
105MP0005075_abnormal_melanosome_morpholog0.60929202
106MP0005645_abnormal_hypothalamus_physiol0.60869021
107MP0001915_intracranial_hemorrhage0.58993279
108MP0003795_abnormal_bone_structure0.58857740
109MP0000609_abnormal_liver_physiology0.57617157
110MP0008569_lethality_at_weaning0.57038599
111MP0004859_abnormal_synaptic_plasticity0.56671906
112MP0009765_abnormal_xenobiotic_induced0.55926173
113MP0003633_abnormal_nervous_system0.55874063
114MP0010307_abnormal_tumor_latency0.55806667
115MP0005670_abnormal_white_adipose0.55640097
116MP0005390_skeleton_phenotype0.54350835
117MP0000490_abnormal_crypts_of0.54251891
118MP0002693_abnormal_pancreas_physiology0.53939708
119MP0004883_abnormal_blood_vessel0.53916012
120MP0005666_abnormal_adipose_tissue0.53256252
121MP0004142_abnormal_muscle_tone0.53034942
122MP0004742_abnormal_vestibular_system0.52758262
123MP0009115_abnormal_fat_cell0.52394753
124MP0004043_abnormal_pH_regulation0.52384603
125MP0000371_diluted_coat_color0.49156549
126MP0009763_increased_sensitivity_to0.49033033
127MP0002095_abnormal_skin_pigmentation0.47914170

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)5.42157412
2Cerebral aneurysm (HP:0004944)4.88514227
3Vascular tortuosity (HP:0004948)4.69391102
4Systemic lupus erythematosus (HP:0002725)4.47947371
5Aortic aneurysm (HP:0004942)4.32940688
6Recurrent fungal infections (HP:0002841)4.03784086
7Eczematoid dermatitis (HP:0000976)4.01591105
8Retrobulbar optic neuritis (HP:0100654)3.90435350
9Optic neuritis (HP:0100653)3.90435350
10Thyroiditis (HP:0100646)3.78927956
11Recurrent abscess formation (HP:0002722)3.73099068
12Chronic diarrhea (HP:0002028)3.70779550
13T lymphocytopenia (HP:0005403)3.64606757
14Chronic mucocutaneous candidiasis (HP:0002728)3.60713253
15Recurrent cutaneous fungal infections (HP:0011370)3.60713253
16Recurrent viral infections (HP:0004429)3.59858434
17Orchitis (HP:0100796)3.53263626
18Recurrent bacterial skin infections (HP:0005406)3.52765536
19Abnormality of T cell number (HP:0011839)3.43715263
20Disproportionate tall stature (HP:0001519)3.38104837
21Stomach cancer (HP:0012126)3.36723470
22Abnormality of the fingertips (HP:0001211)3.34535863
23Eosinophilia (HP:0001880)3.32614825
24Gastrointestinal infarctions (HP:0005244)3.32506820
25Encephalitis (HP:0002383)3.31658332
26Pulmonary infiltrates (HP:0002113)3.24412318
27Autoimmune hemolytic anemia (HP:0001890)3.23799365
28Striae distensae (HP:0001065)3.20471646
29Panhypogammaglobulinemia (HP:0003139)3.18644360
30Hemiplegia (HP:0002301)3.05957029
31Glomerulonephritis (HP:0000099)3.05437088
32Hematochezia (HP:0002573)3.01954160
33Recurrent skin infections (HP:0001581)3.00808614
34Retinal atrophy (HP:0001105)2.96988004
35IgM deficiency (HP:0002850)2.93966759
36Keratoconjunctivitis sicca (HP:0001097)2.90885279
37Agammaglobulinemia (HP:0004432)2.84561336
38Severe combined immunodeficiency (HP:0004430)2.82860158
39Abnormality of eosinophils (HP:0001879)2.80072715
40Hemoptysis (HP:0002105)2.78828034
41Keratoconjunctivitis (HP:0001096)2.77335987
42Colitis (HP:0002583)2.76835211
43Abnormality of T cell physiology (HP:0011840)2.76196528
44Cellulitis (HP:0100658)2.75715914
45Aortic dissection (HP:0002647)2.73545763
46Bicuspid aortic valve (HP:0001647)2.69848625
47Mitral valve prolapse (HP:0001634)2.69305838
48Abnormality of B cell number (HP:0010975)2.67295101
49B lymphocytopenia (HP:0010976)2.67295101
50Abnormality of liposaccharide metabolism (HP:0010968)2.64174393
51Abnormality of glycosphingolipid metabolism (HP:0004343)2.64174393
52Abnormality of glycolipid metabolism (HP:0010969)2.64174393
53Recurrent gram-negative bacterial infections (HP:0005420)2.57461198
54Inflammation of the large intestine (HP:0002037)2.55767922
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.53300280
56Granulocytopenia (HP:0001913)2.52220519
57Meningitis (HP:0001287)2.51935335
58Ocular albinism (HP:0001107)2.50811445
59Chest pain (HP:0100749)2.50085759
60Abnormality of T cells (HP:0002843)2.46335472
61Leukocytosis (HP:0001974)2.45400695
62Urethral obstruction (HP:0000796)2.45065735
63Increased IgM level (HP:0003496)2.44448156
64Increased cerebral lipofuscin (HP:0011813)2.43958930
65Combined immunodeficiency (HP:0005387)2.42833779
66Lymphopenia (HP:0001888)2.41925015
67Gastrointestinal inflammation (HP:0004386)2.41541953
68Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.41454027
69Cheilitis (HP:0100825)2.40545895
70Spontaneous hematomas (HP:0007420)2.37661878
71Mediastinal lymphadenopathy (HP:0100721)2.36747032
72Dysostosis multiplex (HP:0000943)2.31470205
73Chronic otitis media (HP:0000389)2.29851111
74Autoimmune thrombocytopenia (HP:0001973)2.28286419
75Papilledema (HP:0001085)2.27434022
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.25993643
77Blue irides (HP:0000635)2.25748896
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.25670886
79Volvulus (HP:0002580)2.25663170
80Prolonged bleeding time (HP:0003010)2.23006571
81Exotropia (HP:0000577)2.22396116
82Disinhibition (HP:0000734)2.21780818
83Macroorchidism (HP:0000053)2.21379992
84Pulmonary embolism (HP:0002204)2.19529514
85Viral hepatitis (HP:0006562)2.17439733
86Gingival bleeding (HP:0000225)2.16845373
87Recurrent sinusitis (HP:0011108)2.15517056
88Hypoplasia of the thymus (HP:0000778)2.14656382
89Generalized hypopigmentation of hair (HP:0011358)2.14126523
90Elevated erythrocyte sedimentation rate (HP:0003565)2.10840539
91Verrucae (HP:0200043)2.10791070
92Papilloma (HP:0012740)2.10791070
93Abnormality of the prostate (HP:0008775)2.10717825
94Myositis (HP:0100614)2.08810452
95Hyperventilation (HP:0002883)2.06421515
96Osteomyelitis (HP:0002754)2.06404067
97Abnormality of the pleura (HP:0002103)2.06157776
98Vasculitis (HP:0002633)2.05993327
99Recurrent pneumonia (HP:0006532)2.04964311
100Pustule (HP:0200039)2.04559514
101Mutism (HP:0002300)2.04185136
102Obstructive lung disease (HP:0006536)2.02690955
103Chronic obstructive pulmonary disease (HP:0006510)2.02690955
104Iris hypopigmentation (HP:0007730)2.02200412
105Abnormality of polysaccharide metabolism (HP:0011012)2.01972679
106Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01972679
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01972679
108Sepsis (HP:0100806)2.00649431
109Increased IgE level (HP:0003212)2.00635138
110Subacute progressive viral hepatitis (HP:0006572)2.00485705
111Neoplasm of the tracheobronchial system (HP:0100552)1.99187797
112Alveolar cell carcinoma (HP:0006519)1.95161185
113Persistence of primary teeth (HP:0006335)1.94672766
114Stomatitis (HP:0010280)1.94016659
115Mucopolysacchariduria (HP:0008155)1.93712333
116Urinary glycosaminoglycan excretion (HP:0003541)1.93712333
117Gangrene (HP:0100758)1.93381860
118Complement deficiency (HP:0004431)1.93028099
119Epistaxis (HP:0000421)1.90217057
120Prostate neoplasm (HP:0100787)1.90015897
121Joint swelling (HP:0001386)1.89951258
122Periodontitis (HP:0000704)1.89866671
123Gastrointestinal stroma tumor (HP:0100723)1.89317775
124Lymphoma (HP:0002665)1.88464193
125Fatigue (HP:0012378)1.88352690
126Spondylolisthesis (HP:0003302)1.88064542
127Arnold-Chiari malformation (HP:0002308)1.87302294
128Gingivitis (HP:0000230)1.87289406
129Recurrent bronchitis (HP:0002837)1.86644387
130Urticaria (HP:0001025)1.85010425
131Impaired platelet aggregation (HP:0003540)1.84162330
132Abnormal platelet function (HP:0011869)1.84162330
133Slow saccadic eye movements (HP:0000514)1.82505703
134IgA deficiency (HP:0002720)1.81019464
135Abnormality of the intervertebral disk (HP:0005108)1.80835232
136Genetic anticipation (HP:0003743)1.80243401
137Abnormality of the peritoneum (HP:0002585)1.78537189
138Abnormality of macrophages (HP:0004311)1.78502841
139IgG deficiency (HP:0004315)1.78037225
140Chronic sinusitis (HP:0011109)1.77614317
141Arterial thrombosis (HP:0004420)1.77188955
142Anorexia (HP:0002039)1.75496990
143Dilatation of the ascending aorta (HP:0005111)1.75224885

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.74093000
2GRK73.92069473
3MAP4K13.35399731
4ITK3.11644690
5SIK22.66126322
6TXK2.52926529
7CAMK1D2.18829664
8CSF1R2.10696230
9CDK122.08811874
10MAPK152.06447678
11SIK32.02918698
12EEF2K2.01822145
13STK102.00244385
14CAMK1G1.96273849
15RIPK41.92138057
16ADRBK21.83717338
17MAP3K101.82073424
18ACVR1B1.77050917
19MAP3K131.71881443
20ZAP701.71365965
21PRPF4B1.70238084
22TYK21.69579546
23JAK11.58556368
24HCK1.56106278
25SIK11.40569395
26BTK1.35508044
27SYK1.32567050
28IRAK41.26883891
29TEC1.26676256
30FGFR31.24497734
31MARK31.21929723
32CSK1.21312005
33NTRK21.18402781
34MAP3K21.17245447
35LCK1.15323320
36CLK11.12387835
37IRAK11.10993985
38MAPK121.08799448
39GRK61.08436034
40STK241.03947403
41FES1.01253985
42MAPK70.99049687
43PIK3CG0.98969237
44EPHB10.98864275
45MAP3K140.97351432
46JAK30.94915350
47RPS6KA40.89973761
48BMPR20.89681192
49PKN20.88046858
50TBK10.87212776
51PIM10.85793318
52MAP3K30.85395703
53STK390.83542236
54EPHA30.82572411
55* LYN0.81831102
56JAK20.79518302
57PRKCH0.79234296
58KIT0.78554778
59PTK60.78015796
60FGFR40.77985036
61CAMK40.77008426
62SGK30.76698663
63HIPK20.73077013
64CDK30.72347392
65PDGFRB0.72064450
66MAPKAPK20.72039991
67FGFR20.71518355
68IKBKE0.71432471
69MAPK130.69063211
70SGK2230.68818983
71SGK4940.68818983
72CAMKK20.68754266
73PTK2B0.68135522
74PRKCQ0.67880264
75ALK0.67399248
76MAP3K70.67057509
77CDK60.66836971
78ERN10.66359704
79BLK0.66314649
80PDK10.66160120
81PINK10.65444363
82MAPK110.64065046
83BRD40.63276911
84TYRO30.61888089
85MAP2K30.58263873
86MAPK40.57243357
87CCNB10.57002582
88NEK90.54805562
89IKBKB0.53115987
90YES10.52764737
91DMPK0.51996133
92CAMKK10.50822461
93RPS6KA60.50018027
94WNK10.49877052
95STK380.49315665
96PIK3CA0.49213548
97TNK20.47679022
98WNK40.47303988
99MAP3K10.47196150
100IGF1R0.46261690
101SGK20.46145444
102CAMK10.45836464
103MATK0.45290208
104FGR0.44700396
105EGFR0.43839748
106MARK20.43703178
107STK110.43355247
108CHUK0.43087745
109FYN0.42980556
110TAOK30.42617494
111MAP3K90.42273107
112IRAK20.41139942
113MELK0.41042218
114RPS6KC10.40710235
115RPS6KL10.40710235
116RET0.40254791
117SGK10.39598284
118ABL10.39467293
119TRPM70.38461025
120CDK90.37883674
121INSR0.36317720
122INSRR0.35920555
123TSSK60.35431970
124PAK40.35117079
125GRK50.35103415
126CDC42BPA0.34715159
127STK40.34521851
128PRKAA20.34213724
129FRK0.32946827
130LRRK20.31036729
131PRKD10.30553335
132TRIB30.30193793
133NLK0.29517685

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.75899766
2B cell receptor signaling pathway_Homo sapiens_hsa046622.66436218
3Osteoclast differentiation_Homo sapiens_hsa043802.61121847
4Allograft rejection_Homo sapiens_hsa053302.39240359
5Staphylococcus aureus infection_Homo sapiens_hsa051502.35771217
6Autoimmune thyroid disease_Homo sapiens_hsa053202.29525436
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07184427
8T cell receptor signaling pathway_Homo sapiens_hsa046602.06723149
9Leishmaniasis_Homo sapiens_hsa051402.05663732
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89571740
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.79500832
12Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.76767524
13Hematopoietic cell lineage_Homo sapiens_hsa046401.75553976
14Chronic myeloid leukemia_Homo sapiens_hsa052201.67301167
15Type I diabetes mellitus_Homo sapiens_hsa049401.63818366
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.63256366
17Pancreatic cancer_Homo sapiens_hsa052121.60565958
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58958967
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.58419977
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54922947
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52971632
22Measles_Homo sapiens_hsa051621.47484596
23Colorectal cancer_Homo sapiens_hsa052101.45516071
24Chemokine signaling pathway_Homo sapiens_hsa040621.43937181
25Antigen processing and presentation_Homo sapiens_hsa046121.39379127
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.37080456
27Asthma_Homo sapiens_hsa053101.36505261
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.36160959
29Toxoplasmosis_Homo sapiens_hsa051451.33958160
30Nitrogen metabolism_Homo sapiens_hsa009101.33178191
31Hepatitis B_Homo sapiens_hsa051611.25821567
32Platelet activation_Homo sapiens_hsa046111.23472384
33Tuberculosis_Homo sapiens_hsa051521.21694587
34Pertussis_Homo sapiens_hsa051331.20862126
35Acute myeloid leukemia_Homo sapiens_hsa052211.17809131
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.12020322
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11646108
38Influenza A_Homo sapiens_hsa051641.11622492
39Non-small cell lung cancer_Homo sapiens_hsa052231.05006794
40Type II diabetes mellitus_Homo sapiens_hsa049301.03247209
41Malaria_Homo sapiens_hsa051441.02571850
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02110697
43Other glycan degradation_Homo sapiens_hsa005111.01631331
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01446606
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00717997
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99771827
47Lysosome_Homo sapiens_hsa041420.95583167
48TNF signaling pathway_Homo sapiens_hsa046680.94155072
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.93810611
50Renin secretion_Homo sapiens_hsa049240.92507758
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91998536
52NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89928417
53Dorso-ventral axis formation_Homo sapiens_hsa043200.89142382
54ABC transporters_Homo sapiens_hsa020100.87149584
55Notch signaling pathway_Homo sapiens_hsa043300.85808877
56Adherens junction_Homo sapiens_hsa045200.85549387
57Renal cell carcinoma_Homo sapiens_hsa052110.85501413
58Herpes simplex infection_Homo sapiens_hsa051680.85356707
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82647977
60Rheumatoid arthritis_Homo sapiens_hsa053230.82646712
61Prolactin signaling pathway_Homo sapiens_hsa049170.81492784
62Endocytosis_Homo sapiens_hsa041440.80907895
63FoxO signaling pathway_Homo sapiens_hsa040680.80348546
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79952426
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79506392
66VEGF signaling pathway_Homo sapiens_hsa043700.78842018
67African trypanosomiasis_Homo sapiens_hsa051430.78030585
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77914720
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77729392
70Glioma_Homo sapiens_hsa052140.76915276
71HTLV-I infection_Homo sapiens_hsa051660.76864179
72mTOR signaling pathway_Homo sapiens_hsa041500.76633998
73MAPK signaling pathway_Homo sapiens_hsa040100.75805525
74Estrogen signaling pathway_Homo sapiens_hsa049150.74744513
75Rap1 signaling pathway_Homo sapiens_hsa040150.74544155
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73558212
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71926798
78Apoptosis_Homo sapiens_hsa042100.70198456
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69652738
80Regulation of autophagy_Homo sapiens_hsa041400.69627811
81Lysine degradation_Homo sapiens_hsa003100.69206988
82Viral myocarditis_Homo sapiens_hsa054160.69120139
83Legionellosis_Homo sapiens_hsa051340.68700567
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.67335756
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.67034797
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66755745
87Inositol phosphate metabolism_Homo sapiens_hsa005620.63840350
88ErbB signaling pathway_Homo sapiens_hsa040120.63593213
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63521672
90Endometrial cancer_Homo sapiens_hsa052130.62951217
91Viral carcinogenesis_Homo sapiens_hsa052030.62898735
92Choline metabolism in cancer_Homo sapiens_hsa052310.62535520
93Shigellosis_Homo sapiens_hsa051310.62529584
94Insulin resistance_Homo sapiens_hsa049310.62337309
95Salmonella infection_Homo sapiens_hsa051320.62010082
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.60978507
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60577599
98Phagosome_Homo sapiens_hsa041450.59870305
99Long-term potentiation_Homo sapiens_hsa047200.59726952
100Prostate cancer_Homo sapiens_hsa052150.59407269
101Oxytocin signaling pathway_Homo sapiens_hsa049210.57421739
102cAMP signaling pathway_Homo sapiens_hsa040240.55309278
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55209564
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54751471
105Cholinergic synapse_Homo sapiens_hsa047250.54596325
106Gastric acid secretion_Homo sapiens_hsa049710.53755530
107GnRH signaling pathway_Homo sapiens_hsa049120.53155389
108Olfactory transduction_Homo sapiens_hsa047400.52962427
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52006574
110Graft-versus-host disease_Homo sapiens_hsa053320.51571229
111Small cell lung cancer_Homo sapiens_hsa052220.51126174
112Hepatitis C_Homo sapiens_hsa051600.51002727
113Epstein-Barr virus infection_Homo sapiens_hsa051690.49206264
114Morphine addiction_Homo sapiens_hsa050320.48866948
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44471905
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42871311
117Ras signaling pathway_Homo sapiens_hsa040140.42826458
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41432729
119Linoleic acid metabolism_Homo sapiens_hsa005910.40245157
120Long-term depression_Homo sapiens_hsa047300.39772939
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39610193
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.39259531
123Ether lipid metabolism_Homo sapiens_hsa005650.39252027

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