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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Unlike the other gene family members, this gene does not encode an antigenic peptide. Nothing is presently known about the function of this protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.62864841
2regulation of translational fidelity (GO:0006450)6.36044316
3nuclear pore organization (GO:0006999)5.74811203
4homocysteine metabolic process (GO:0050667)5.74727093
5pore complex assembly (GO:0046931)4.82587326
6DNA replication checkpoint (GO:0000076)4.81676608
7formation of translation preinitiation complex (GO:0001731)4.50440360
8ribosomal small subunit biogenesis (GO:0042274)4.43425144
9oxidative phosphorylation (GO:0006119)4.33678592
10mitotic nuclear envelope disassembly (GO:0007077)4.31867812
11tRNA aminoacylation for protein translation (GO:0006418)4.30591981
12proline biosynthetic process (GO:0006561)4.28360473
13amino acid activation (GO:0043038)4.15944197
14tRNA aminoacylation (GO:0043039)4.15944197
15maturation of SSU-rRNA (GO:0030490)4.09425197
16ribosomal large subunit biogenesis (GO:0042273)4.05712889
17protoporphyrinogen IX metabolic process (GO:0046501)4.03826504
18DNA strand elongation involved in DNA replication (GO:0006271)4.03477304
19iron ion import (GO:0097286)4.01607009
20nuclear envelope disassembly (GO:0051081)4.00918217
21membrane disassembly (GO:0030397)4.00918217
22DNA unwinding involved in DNA replication (GO:0006268)3.98971386
23DNA replication initiation (GO:0006270)3.93314380
24DNA strand elongation (GO:0022616)3.91527240
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91434034
26midgut development (GO:0007494)3.89571939
27ribonucleoprotein complex biogenesis (GO:0022613)3.88995824
28COPI coating of Golgi vesicle (GO:0048205)3.86589031
29Golgi transport vesicle coating (GO:0048200)3.86589031
30L-serine metabolic process (GO:0006563)3.85508810
31folic acid metabolic process (GO:0046655)3.83780639
32viral transcription (GO:0019083)3.81168233
33regulation of translational elongation (GO:0006448)3.77604383
34translational termination (GO:0006415)3.74836545
35ribosome biogenesis (GO:0042254)3.74336775
36mitotic sister chromatid segregation (GO:0000070)3.71312539
37telomere maintenance via semi-conservative replication (GO:0032201)3.69203007
38purine nucleobase biosynthetic process (GO:0009113)3.68634152
39mitotic chromosome condensation (GO:0007076)3.62845812
40nucleobase-containing small molecule interconversion (GO:0015949)3.51241824
41folic acid-containing compound biosynthetic process (GO:0009396)3.50836430
42DNA topological change (GO:0006265)3.50309456
43nucleobase biosynthetic process (GO:0046112)3.48361128
44sister chromatid segregation (GO:0000819)3.46774911
45ATP synthesis coupled proton transport (GO:0015986)3.46502447
46energy coupled proton transport, down electrochemical gradient (GO:0015985)3.46502447
47folic acid-containing compound metabolic process (GO:0006760)3.43977688
48protoporphyrinogen IX biosynthetic process (GO:0006782)3.42928494
49serine family amino acid biosynthetic process (GO:0009070)3.38835173
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38581340
51translational initiation (GO:0006413)3.37085655
52oxaloacetate metabolic process (GO:0006107)3.36455562
53cotranslational protein targeting to membrane (GO:0006613)3.28767866
54ribosome assembly (GO:0042255)3.26467312
55translational elongation (GO:0006414)3.25988133
56regulation of RNA export from nucleus (GO:0046831)3.25258478
57protein targeting to ER (GO:0045047)3.24288197
58ribosomal small subunit assembly (GO:0000028)3.24269972
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23156605
60IMP biosynthetic process (GO:0006188)3.17830793
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.16729980
62telomere maintenance via recombination (GO:0000722)3.16700407
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.14947427
64synapsis (GO:0007129)3.14287391
65rRNA methylation (GO:0031167)3.13946268
66regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12551974
67regulation of mitotic spindle organization (GO:0060236)3.10196648
68tricarboxylic acid cycle (GO:0006099)3.08727225
69nuclear envelope organization (GO:0006998)3.07577104
70protein localization to endoplasmic reticulum (GO:0070972)3.07452564
71maturation of 5.8S rRNA (GO:0000460)3.07061208
72regulation of centriole replication (GO:0046599)3.06434860
73regulation of histone H3-K27 methylation (GO:0061085)3.05564930
74cellular protein complex disassembly (GO:0043624)3.05039206
75mitochondrial DNA metabolic process (GO:0032042)2.99965842
76regulation of histone H3-K4 methylation (GO:0051569)2.99768848
77mitotic recombination (GO:0006312)2.99177714
78rRNA modification (GO:0000154)2.98646374
79pteridine-containing compound metabolic process (GO:0042558)2.96584199
80tetrahydrofolate metabolic process (GO:0046653)2.95948939
81protein export from nucleus (GO:0006611)2.95045176
82mitochondrial RNA metabolic process (GO:0000959)2.93992426
83tyrosine metabolic process (GO:0006570)2.92492773
84urea cycle (GO:0000050)2.91042129
85resolution of meiotic recombination intermediates (GO:0000712)2.90136901
86glutamine metabolic process (GO:0006541)2.86417039
87biotin metabolic process (GO:0006768)2.85622801
88gas transport (GO:0015669)2.84905125
89viral life cycle (GO:0019058)2.84708173
90cellular component biogenesis (GO:0044085)2.84566535
91aerobic respiration (GO:0009060)2.84447657
92oxygen transport (GO:0015671)2.84364593
93protein complex disassembly (GO:0043241)2.84150468
94transcription from mitochondrial promoter (GO:0006390)2.83954448
95macromolecular complex disassembly (GO:0032984)2.81562331
96rRNA processing (GO:0006364)2.81017619
97translation (GO:0006412)2.80864262
98protein localization to kinetochore (GO:0034501)2.79383253
99IMP metabolic process (GO:0046040)2.78482829
100kinetochore organization (GO:0051383)2.77636869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.93522516
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.99194143
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67002356
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36792476
5ZNF263_19887448_ChIP-Seq_K562_Human3.19367656
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.17154059
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.16297673
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.02170780
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82488024
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80197411
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63031901
12XRN2_22483619_ChIP-Seq_HELA_Human2.61180264
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59509192
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54267349
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53785445
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.49448144
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.29905174
18DCP1A_22483619_ChIP-Seq_HELA_Human2.26073891
19AR_21909140_ChIP-Seq_LNCAP_Human2.20370976
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.17427121
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.16947685
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.16577193
23TTF2_22483619_ChIP-Seq_HELA_Human2.08328750
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.08279173
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03344064
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93556693
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91790194
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87281186
29GATA1_22025678_ChIP-Seq_K562_Human1.83944722
30KDM5A_27292631_Chip-Seq_BREAST_Human1.83424054
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83083145
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83017033
33NCOR1_26117541_ChIP-Seq_K562_Human1.81967007
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.78638685
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.74604164
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71019455
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65049764
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64497723
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64412127
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60548514
41TFEB_21752829_ChIP-Seq_HELA_Human1.60192535
42ELK1_19687146_ChIP-ChIP_HELA_Human1.55877249
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.55676338
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55432522
45FOXP3_21729870_ChIP-Seq_TREG_Human1.55248536
46MYC_22102868_ChIP-Seq_BL_Human1.53478135
47GABP_19822575_ChIP-Seq_HepG2_Human1.53247575
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51214331
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.49517842
50PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49426955
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49236736
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48960004
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45621621
54ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.43834933
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43400909
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42928917
57VDR_23849224_ChIP-Seq_CD4+_Human1.40189254
58CHD1_26751641_Chip-Seq_LNCaP_Human1.39376736
59CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37973458
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37622342
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36382906
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36162381
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32007717
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30659754
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28901055
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.28516137
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28321006
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28017227
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27354854
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27266854
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27243339
72GATA1_19941826_ChIP-Seq_K562_Human1.21113305
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.20968714
74E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20384250
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18112506
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17402859
77CIITA_25753668_ChIP-Seq_RAJI_Human1.16966509
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16347394
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16276572
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13385716
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08494441
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06965661
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04736016
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02732315
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99554573
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97962242
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96938961
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96912708
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95131701
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94332851
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93846421
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93367545
93GATA2_19941826_ChIP-Seq_K562_Human0.88366710
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86861151
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83028424
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82365684
97ATF3_27146783_Chip-Seq_COLON_Human0.78848715
98VDR_21846776_ChIP-Seq_THP-1_Human0.77965886
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.77499669
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.76464931

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.05432243
2MP0004957_abnormal_blastocyst_morpholog3.92263341
3MP0005451_abnormal_body_composition3.61933774
4MP0008058_abnormal_DNA_repair3.61035212
5MP0003111_abnormal_nucleus_morphology3.54615668
6MP0003693_abnormal_embryo_hatching3.47406485
7MP0004147_increased_porphyrin_level3.43328025
8MP0008057_abnormal_DNA_replication3.31449672
9MP0004233_abnormal_muscle_weight3.10775859
10MP0008995_early_reproductive_senescence3.01155088
11MP0003077_abnormal_cell_cycle2.83364151
12MP0003786_premature_aging2.69605609
13MP0008932_abnormal_embryonic_tissue2.51869680
14MP0003656_abnormal_erythrocyte_physiolo2.34569497
15MP0005171_absent_coat_pigmentation2.29357591
16MP0009697_abnormal_copulation2.29064054
17MP0006036_abnormal_mitochondrial_physio2.03605352
18MP0008007_abnormal_cellular_replicative2.00091019
19MP0006035_abnormal_mitochondrial_morpho1.92625866
20MP0003186_abnormal_redox_activity1.86991832
21MP0005083_abnormal_biliary_tract1.82737199
22MP0002009_preneoplasia1.82308856
23MP0001661_extended_life_span1.73784640
24MP0003718_maternal_effect1.71856132
25MP0002396_abnormal_hematopoietic_system1.71008548
26MP0000678_abnormal_parathyroid_gland1.69459220
27MP0000350_abnormal_cell_proliferation1.66731871
28MP0001730_embryonic_growth_arrest1.65619120
29MP0001348_abnormal_lacrimal_gland1.64908735
30MP0001764_abnormal_homeostasis1.64616278
31MP0005408_hypopigmentation1.57450033
32MP0003959_abnormal_lean_body1.53894047
33MP0010307_abnormal_tumor_latency1.52462697
34MP0001672_abnormal_embryogenesis/_devel1.52076204
35MP0005380_embryogenesis_phenotype1.52076204
36MP0004858_abnormal_nervous_system1.46971208
37MP0001697_abnormal_embryo_size1.46520873
38MP0003984_embryonic_growth_retardation1.45415554
39MP0002080_prenatal_lethality1.44940251
40MP0003123_paternal_imprinting1.43657570
41MP0000313_abnormal_cell_death1.40223377
42MP0002088_abnormal_embryonic_growth/wei1.39747041
43MP0000358_abnormal_cell_content/1.39526719
44MP0002877_abnormal_melanocyte_morpholog1.38452658
45MP0003705_abnormal_hypodermis_morpholog1.36758470
46MP0000003_abnormal_adipose_tissue1.36698098
47MP0003806_abnormal_nucleotide_metabolis1.24136499
48MP0002132_abnormal_respiratory_system1.23897686
49MP0005332_abnormal_amino_acid1.23780889
50MP0002086_abnormal_extraembryonic_tissu1.20271455
51MP0005645_abnormal_hypothalamus_physiol1.18186431
52MP0004808_abnormal_hematopoietic_stem1.18018104
53MP0003136_yellow_coat_color1.17340390
54MP0000372_irregular_coat_pigmentation1.15133660
55MP0001873_stomach_inflammation1.14130869
56MP0002210_abnormal_sex_determination1.13889184
57MP0005647_abnormal_sex_gland1.13836231
58MP0010234_abnormal_vibrissa_follicle1.10607054
59MP0001929_abnormal_gametogenesis1.10267290
60MP0005076_abnormal_cell_differentiation1.02724751
61MP0003221_abnormal_cardiomyocyte_apopto1.02022270
62MP0002269_muscular_atrophy0.99256326
63MP0005636_abnormal_mineral_homeostasis0.97366227
64MP0002084_abnormal_developmental_patter0.88989694
65MP0003941_abnormal_skin_development0.88390971
66MP0000609_abnormal_liver_physiology0.87423986
67MP0002019_abnormal_tumor_incidence0.86938600
68MP0005397_hematopoietic_system_phenotyp0.85839047
69MP0001545_abnormal_hematopoietic_system0.85839047
70MP0000747_muscle_weakness0.85369211
71MP0001145_abnormal_male_reproductive0.83735752
72MP0002085_abnormal_embryonic_tissue0.79436848
73MP0009333_abnormal_splenocyte_physiolog0.78092019
74MP0003699_abnormal_female_reproductive0.77317890
75MP0005384_cellular_phenotype0.76748673
76MP0008770_decreased_survivor_rate0.76468846
77MP0001727_abnormal_embryo_implantation0.75954537
78MP0000653_abnormal_sex_gland0.75710739
79MP0003698_abnormal_male_reproductive0.74537938
80MP0009672_abnormal_birth_weight0.73743459
81MP0008775_abnormal_heart_ventricle0.73671933
82MP0002970_abnormal_white_adipose0.71714138
83MP0000598_abnormal_liver_morphology0.71367856
84MP0004197_abnormal_fetal_growth/weight/0.70911565
85MP0004185_abnormal_adipocyte_glucose0.69615163
86MP0005220_abnormal_exocrine_pancreas0.69241593
87MP0002161_abnormal_fertility/fecundity0.69105481
88MP0005410_abnormal_fertilization0.67475383
89MP0004145_abnormal_muscle_electrophysio0.67403939
90MP0002075_abnormal_coat/hair_pigmentati0.66955496
91MP0001186_pigmentation_phenotype0.66525509
92MP0005058_abnormal_lysosome_morphology0.66430338
93MP0005621_abnormal_cell_physiology0.66224820
94MP0009931_abnormal_skin_appearance0.64191136
95MP0005375_adipose_tissue_phenotype0.63476048
96MP0002938_white_spotting0.63276957
97MP0002160_abnormal_reproductive_system0.62134883
98MP0000013_abnormal_adipose_tissue0.57815202
99MP0005319_abnormal_enzyme/_coenzyme0.57323420
100MP0005330_cardiomyopathy0.56094325

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)5.02207757
2Cholecystitis (HP:0001082)5.02207757
3Abnormality of glycolysis (HP:0004366)4.48014848
4Reticulocytosis (HP:0001923)4.11903563
5Hyperthyroidism (HP:0000836)4.09092767
6Increased serum pyruvate (HP:0003542)4.05985308
7Abnormality of reticulocytes (HP:0004312)4.04513913
8Truncus arteriosus (HP:0001660)4.01945309
9Reticulocytopenia (HP:0001896)3.88913540
10Birth length less than 3rd percentile (HP:0003561)3.71171719
11Pallor (HP:0000980)3.69963983
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.54196171
13Chromsome breakage (HP:0040012)3.50864498
14Abnormal hemoglobin (HP:0011902)3.40329715
15Cerebral edema (HP:0002181)3.21090305
16Ankyloglossia (HP:0010296)3.20478313
17Homocystinuria (HP:0002156)3.17881727
18Abnormality of homocysteine metabolism (HP:0010919)3.17881727
19Cholelithiasis (HP:0001081)3.10903826
20Acute encephalopathy (HP:0006846)3.10370453
21Macrocytic anemia (HP:0001972)3.08328119
22Polycythemia (HP:0001901)3.07288106
23Abnormality of cells of the erythroid lineage (HP:0012130)3.03112791
24Sparse lateral eyebrow (HP:0005338)3.02716584
25Calcaneovalgus deformity (HP:0001848)3.01931137
26Progressive muscle weakness (HP:0003323)2.97969985
27Abnormality of the heme biosynthetic pathway (HP:0010472)2.94697697
28Abnormality of the tricuspid valve (HP:0001702)2.94014824
29Abnormal mitochondria in muscle tissue (HP:0008316)2.93932886
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.91543194
31Abnormality of alanine metabolism (HP:0010916)2.91543194
32Hyperalaninemia (HP:0003348)2.91543194
33Hypoparathyroidism (HP:0000829)2.89115092
34Ileus (HP:0002595)2.87635846
35Hypertensive crisis (HP:0100735)2.82760014
36Seborrheic dermatitis (HP:0001051)2.81823099
37Dysmetric saccades (HP:0000641)2.76304965
38Cortical dysplasia (HP:0002539)2.76228960
39Acute necrotizing encephalopathy (HP:0006965)2.73358590
40Abnormal gallbladder morphology (HP:0012437)2.69968112
41Bowel incontinence (HP:0002607)2.67083293
42Deformed tarsal bones (HP:0008119)2.64050869
43Abnormal large intestine physiology (HP:0012700)2.62471541
44Overlapping toe (HP:0001845)2.51672082
45Abnormal number of erythroid precursors (HP:0012131)2.48500924
46Hyperammonemia (HP:0001987)2.47301940
47Microvesicular hepatic steatosis (HP:0001414)2.45048572
48Ragged-red muscle fibers (HP:0003200)2.37823117
49Spastic paraparesis (HP:0002313)2.34705244
50Abnormality of pyrimidine metabolism (HP:0004353)2.31123699
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.30223897
52Breast hypoplasia (HP:0003187)2.28181727
53Increased CSF lactate (HP:0002490)2.27855586
54Abnormality of the preputium (HP:0100587)2.25991186
55Upper limb muscle weakness (HP:0003484)2.24476195
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.23520683
57Abnormality of the gallbladder (HP:0005264)2.22344937
58Increased serum lactate (HP:0002151)2.21027492
59Cerebellar dysplasia (HP:0007033)2.16639459
60Respiratory difficulties (HP:0002880)2.16007857
61Abnormally folded helix (HP:0008544)2.15009714
62Abnormality of oral frenula (HP:0000190)2.14645313
63Abnormality of the calcaneus (HP:0008364)2.13594438
64Progressive macrocephaly (HP:0004481)2.10044774
65Premature ovarian failure (HP:0008209)2.08453886
66Abnormality of DNA repair (HP:0003254)2.07129773
67Duplicated collecting system (HP:0000081)2.06180839
68Redundant skin (HP:0001582)2.04393223
69Submucous cleft hard palate (HP:0000176)2.03655036
70Myelodysplasia (HP:0002863)2.02761255
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01616363
72Increased intramyocellular lipid droplets (HP:0012240)1.99871830
73Lactic acidosis (HP:0003128)1.99786839
74Atelectasis (HP:0100750)1.98537529
75Aplasia/Hypoplasia of the earlobes (HP:0009906)1.98006434
76Neoplasm of head and neck (HP:0012288)1.96654406
77Esophageal neoplasm (HP:0100751)1.96654406
78Aplasia/Hypoplasia of the thymus (HP:0010515)1.95606054
79Aplasia/Hypoplasia of the uvula (HP:0010293)1.95057025
80Lipid accumulation in hepatocytes (HP:0006561)1.93091374
81Increased hepatocellular lipid droplets (HP:0006565)1.92730764
82Breech presentation (HP:0001623)1.90848353
83Hyperbilirubinemia (HP:0002904)1.90761625
84Hypokinesia (HP:0002375)1.90107627
85Acute myeloid leukemia (HP:0004808)1.88663132
86Sandal gap (HP:0001852)1.88453808
87Abnormality of methionine metabolism (HP:0010901)1.87965917
88Entropion (HP:0000621)1.85913256
89Pancytopenia (HP:0001876)1.85672769
90Overfolded helix (HP:0000396)1.85515919
91Hepatocellular carcinoma (HP:0001402)1.85406733
92Secondary amenorrhea (HP:0000869)1.83003559
93Multiple enchondromatosis (HP:0005701)1.82914790
94Patellar dislocation (HP:0002999)1.82542030
95Mitochondrial inheritance (HP:0001427)1.80855805
96Abnormality of chromosome stability (HP:0003220)1.80724968
97Nonimmune hydrops fetalis (HP:0001790)1.80556504
98Increased nuchal translucency (HP:0010880)1.80089887
99Abnormality of serum amino acid levels (HP:0003112)1.79634025
100Aplastic anemia (HP:0001915)1.78783010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK26.18157953
2EEF2K3.98336265
3EIF2AK13.61942130
4NME23.50033331
5ICK2.95739338
6TTK2.95081220
7PBK2.91567817
8NEK12.53807569
9RIPK42.29739876
10CDC72.22674402
11TSSK62.21918193
12WEE12.21792549
13BRSK22.19735402
14SCYL22.09139199
15PRKD32.04129135
16CCNB12.03894534
17KSR21.96797136
18BMPR21.88299605
19BUB11.82933901
20AKT31.82701480
21WNK41.77560121
22CLK11.69545398
23SRPK11.67498883
24NME11.60052523
25RPS6KB21.59684235
26RAF11.55746861
27PLK41.55483218
28CHEK21.54651789
29MST1R1.54429281
30NEK21.39529911
31BRSK11.39185894
32EIF2AK31.28556336
33IRAK31.28459094
34TRIB31.14571563
35MAP3K81.13647144
36MAP3K21.12781306
37ATR1.12532336
38LATS21.10951942
39CDK121.08668252
40ALK1.01606227
41CHEK10.94794677
42SMG10.91603080
43CDK70.90308810
44STK160.88181256
45CAMK1D0.77214156
46PLK30.76306479
47AURKB0.75723252
48CDK10.71340214
49ZAK0.69911579
50MTOR0.69169990
51STK40.68728963
52MAPKAPK50.66975846
53NEK60.64981215
54PLK10.63961084
55CDK20.63186687
56CDK80.62475633
57BMX0.62437969
58KSR10.61058697
59ATM0.59218197
60ILK0.58685416
61CDK40.58024922
62AURKA0.56597098
63CSNK1E0.56172201
64NTRK30.56001795
65STK390.54996641
66CSNK2A20.54406970
67PIM10.50979046
68CDK30.50124220
69MST40.50008007
70VRK20.49043096
71PAK20.46246393
72PAK10.45345858
73AKT20.43813812
74BRD40.43405280
75PAK40.43200448
76MAPKAPK30.41697299
77MAPK110.41435520
78BRAF0.40899698
79TLK10.37508855
80MKNK10.36848469
81MAP2K10.36556199
82MARK30.36303434
83PIK3CG0.35919322
84MAPK120.35864795
85MAP3K10.35830968
86MET0.35521820
87CAMK1G0.34573475
88PDPK10.33433289
89TRPM70.32998910
90CSNK2A10.32576228
91EIF2AK20.31155407
92YES10.31150173
93MAPK140.30181383
94MAPK100.27598055
95TAOK20.27031689
96PKN20.26890626
97GSK3B0.26539355
98PRKDC0.25047606
99PASK0.24737063
100MAP3K60.23991166

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.36405756
2DNA replication_Homo sapiens_hsa030303.48649300
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.43987884
4Ribosome_Homo sapiens_hsa030103.25478290
5Mismatch repair_Homo sapiens_hsa034303.13471197
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79793760
7One carbon pool by folate_Homo sapiens_hsa006702.60222358
8Biosynthesis of amino acids_Homo sapiens_hsa012302.59516603
9Pyruvate metabolism_Homo sapiens_hsa006202.46627021
10Arginine biosynthesis_Homo sapiens_hsa002202.28111846
11RNA transport_Homo sapiens_hsa030132.20499303
12Homologous recombination_Homo sapiens_hsa034402.17140908
13Carbon metabolism_Homo sapiens_hsa012002.11919898
14Nucleotide excision repair_Homo sapiens_hsa034202.08597951
15Spliceosome_Homo sapiens_hsa030402.02949283
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95494071
17Fanconi anemia pathway_Homo sapiens_hsa034601.82364593
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78010184
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73502009
20Oxidative phosphorylation_Homo sapiens_hsa001901.73259216
21Cell cycle_Homo sapiens_hsa041101.69136523
22RNA polymerase_Homo sapiens_hsa030201.68603408
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.63618291
24Parkinsons disease_Homo sapiens_hsa050121.62692098
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.61558135
26Base excision repair_Homo sapiens_hsa034101.48891370
27Fructose and mannose metabolism_Homo sapiens_hsa000511.45477119
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44640986
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40672829
30Non-homologous end-joining_Homo sapiens_hsa034501.37118688
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33077760
32Selenocompound metabolism_Homo sapiens_hsa004501.30574720
33Pyrimidine metabolism_Homo sapiens_hsa002401.28519344
34Pentose phosphate pathway_Homo sapiens_hsa000301.28000144
35Vitamin B6 metabolism_Homo sapiens_hsa007501.25372587
36Basal transcription factors_Homo sapiens_hsa030221.22879468
37Huntingtons disease_Homo sapiens_hsa050161.20904946
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16349874
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15419141
40Propanoate metabolism_Homo sapiens_hsa006401.14016638
41Proteasome_Homo sapiens_hsa030501.10851040
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10701140
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07929421
44Phenylalanine metabolism_Homo sapiens_hsa003601.07884143
45Alzheimers disease_Homo sapiens_hsa050101.07003371
46Purine metabolism_Homo sapiens_hsa002301.00698864
47mRNA surveillance pathway_Homo sapiens_hsa030151.00314627
48RNA degradation_Homo sapiens_hsa030180.95670204
49Sulfur relay system_Homo sapiens_hsa041220.94923883
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94866575
51Arginine and proline metabolism_Homo sapiens_hsa003300.90588460
52Tyrosine metabolism_Homo sapiens_hsa003500.88051076
53Steroid biosynthesis_Homo sapiens_hsa001000.84931206
54Fatty acid metabolism_Homo sapiens_hsa012120.84754925
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.84228246
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.79159394
57Folate biosynthesis_Homo sapiens_hsa007900.75702364
58N-Glycan biosynthesis_Homo sapiens_hsa005100.72885301
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71841244
60Protein export_Homo sapiens_hsa030600.69877762
61Fatty acid biosynthesis_Homo sapiens_hsa000610.69118502
62Metabolic pathways_Homo sapiens_hsa011000.63323534
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61520622
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58421567
65Thyroid cancer_Homo sapiens_hsa052160.58381705
66Viral carcinogenesis_Homo sapiens_hsa052030.52320954
67Lysine degradation_Homo sapiens_hsa003100.51635888
68Glutathione metabolism_Homo sapiens_hsa004800.51295191
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50043337
70Galactose metabolism_Homo sapiens_hsa000520.47755770
71Oocyte meiosis_Homo sapiens_hsa041140.47327031
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47087874
73Prion diseases_Homo sapiens_hsa050200.46117607
74mTOR signaling pathway_Homo sapiens_hsa041500.46028319
75Chronic myeloid leukemia_Homo sapiens_hsa052200.44726789
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44595767
77HIF-1 signaling pathway_Homo sapiens_hsa040660.41809147
78Fatty acid elongation_Homo sapiens_hsa000620.39180842
79Acute myeloid leukemia_Homo sapiens_hsa052210.37439074
80Non-small cell lung cancer_Homo sapiens_hsa052230.35457996
81Olfactory transduction_Homo sapiens_hsa047400.34375249
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32779380
83Other glycan degradation_Homo sapiens_hsa005110.32460773
84Butanoate metabolism_Homo sapiens_hsa006500.32159806
85Insulin signaling pathway_Homo sapiens_hsa049100.27647858
86Epstein-Barr virus infection_Homo sapiens_hsa051690.24466642
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22190794
88VEGF signaling pathway_Homo sapiens_hsa043700.21308674
89Pancreatic cancer_Homo sapiens_hsa052120.21297332
90Bladder cancer_Homo sapiens_hsa052190.20849680
91Mineral absorption_Homo sapiens_hsa049780.19689391
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.18483683
93Renal cell carcinoma_Homo sapiens_hsa052110.17457378
94Nitrogen metabolism_Homo sapiens_hsa009100.16397747
95Cardiac muscle contraction_Homo sapiens_hsa042600.15654339
96Vitamin digestion and absorption_Homo sapiens_hsa049770.14000205
97Sulfur metabolism_Homo sapiens_hsa009200.13269314
98AMPK signaling pathway_Homo sapiens_hsa041520.12594055
99p53 signaling pathway_Homo sapiens_hsa041150.09586442
100Vibrio cholerae infection_Homo sapiens_hsa051100.08404662

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