ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mesoderm development (GO:0007498)	5.58223116
2	mesenchyme development (GO:0060485)	5.15134845
3	nucleosome assembly (GO:0006334)	4.42912240
4	sex differentiation (GO:0007548)	4.21753558
5	gonadal mesoderm development (GO:0007506)	39.2264027
6	formation of translation preinitiation complex (GO:0001731)	3.93772782
7	ribosomal small subunit biogenesis (GO:0042274)	3.85762245
8	protein-DNA complex assembly (GO:0065004)	3.83527666
9	ribosomal small subunit assembly (GO:0000028)	3.81409279
10	nucleosome organization (GO:0034728)	3.57409912
11	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.41830150
12	N-acetylneuraminate metabolic process (GO:0006054)	3.25451378
13	protein-DNA complex subunit organization (GO:0071824)	3.18736568
14	binding of sperm to zona pellucida (GO:0007339)	3.18573348
15	nucleobase-containing small molecule interconversion (GO:0015949)	3.15078505
16	ribosome assembly (GO:0042255)	3.12826221
17	rRNA modification (GO:0000154)	3.10253979
18	male meiosis (GO:0007140)	3.09149926
19	mitotic metaphase plate congression (GO:0007080)	3.04724085
20	deoxyribonucleotide biosynthetic process (GO:0009263)	2.98876212
21	COPI coating of Golgi vesicle (GO:0048205)	2.83066371
22	Golgi transport vesicle coating (GO:0048200)	2.83066371
23	mitochondrial fusion (GO:0008053)	2.74269690
24	urea metabolic process (GO:0019627)	2.73583058
25	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.71829714
26	nitrogen cycle metabolic process (GO:0071941)	2.69014266
27	ribonucleoprotein complex biogenesis (GO:0022613)	2.67775606
28	glyoxylate metabolic process (GO:0046487)	2.67659572
29	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.67272290
30	rRNA methylation (GO:0031167)	2.64119572
31	phenylpropanoid metabolic process (GO:0009698)	2.64102995
32	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.64015226
33	urea cycle (GO:0000050)	2.63020832
34	proteasome assembly (GO:0043248)	2.62915286
35	protein localization to endoplasmic reticulum (GO:0070972)	2.62293960
36	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.61909370
37	L-phenylalanine metabolic process (GO:0006558)	2.61909370
38	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.61798697
39	synapsis (GO:0007129)	2.61658113
40	de novo posttranslational protein folding (GO:0051084)	2.61458738
41	amino acid salvage (GO:0043102)	2.60777068
42	L-methionine salvage (GO:0071267)	2.60777068
43	L-methionine biosynthetic process (GO:0071265)	2.60777068
44	viral transcription (GO:0019083)	2.59630576
45	cotranslational protein targeting to membrane (GO:0006613)	2.59623017
46	mitotic chromosome condensation (GO:0007076)	2.58083878
47	protein targeting to ER (GO:0045047)	2.58040275
48	regulation of oxidative stress-induced neuron death (GO:1903203)	2.56594243
49	regulation of bile acid biosynthetic process (GO:0070857)	2.55993848
50	proline metabolic process (GO:0006560)	2.55523676
51	translational termination (GO:0006415)	2.54318423
52	glycine metabolic process (GO:0006544)	2.54242731
53	mitochondrial DNA metabolic process (GO:0032042)	2.53704566
54	chromosome organization involved in meiosis (GO:0070192)	2.53535453
55	piRNA metabolic process (GO:0034587)	2.51761038
56	deoxyribonucleoside diphosphate metabolic process (GO:0009186)	2.50930692
57	apoptotic cell clearance (GO:0043277)	2.49686063
58	positive regulation of ligase activity (GO:0051351)	2.49295993
59	translational initiation (GO:0006413)	2.48100897
60	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.47859392
61	de novo protein folding (GO:0006458)	2.47529951
62	regulation of protein activation cascade (GO:2000257)	2.46831275
63	ribosome biogenesis (GO:0042254)	2.46425218
64	metaphase plate congression (GO:0051310)	2.44924852
65	regulation of translational fidelity (GO:0006450)	2.44554698
66	myeloid cell homeostasis (GO:0002262)	2.44210553
67	translational elongation (GO:0006414)	2.43108253
68	drug metabolic process (GO:0017144)	2.43036745
69	cofactor catabolic process (GO:0051187)	2.39983184
70	bile acid biosynthetic process (GO:0006699)	2.39867531
71	alkaloid metabolic process (GO:0009820)	2.39786776
72	fusion of sperm to egg plasma membrane (GO:0007342)	2.39141314
73	meiotic nuclear division (GO:0007126)	2.38711444
74	protein carboxylation (GO:0018214)	2.38425082
75	peptidyl-glutamic acid carboxylation (GO:0017187)	2.38425082
76	sperm-egg recognition (GO:0035036)	2.38292394
77	male meiosis I (GO:0007141)	2.38159404
78	proline biosynthetic process (GO:0006561)	2.37489788
79	mitochondrial DNA replication (GO:0006264)	2.35043641
80	ribosomal large subunit biogenesis (GO:0042273)	2.34899440
81	translation (GO:0006412)	2.34058535
82	regulation of cellular amino acid metabolic process (GO:0006521)	2.34023883
83	mitotic sister chromatid segregation (GO:0000070)	2.33301074
84	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.31837962
85	glutamine family amino acid biosynthetic process (GO:0009084)	2.30866174
86	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.30662120
87	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.29447757
88	oxidative demethylation (GO:0070989)	2.29286087
89	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.26404313
90	complement activation, classical pathway (GO:0006958)	2.26145075
91	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.25908990
92	organ or tissue specific immune response (GO:0002251)	2.24186545
93	tRNA aminoacylation for protein translation (GO:0006418)	2.23182403
94	synaptonemal complex assembly (GO:0007130)	2.23045119
95	meiosis I (GO:0007127)	2.22500899
96	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.20424915
97	L-phenylalanine catabolic process (GO:0006559)	2.20424915
98	regulation of ligase activity (GO:0051340)	2.19702450
99	sulfur amino acid catabolic process (GO:0000098)	2.16033694
100	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.13664548

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.36080224
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.92143900
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.57412706
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.54853930
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.45696146
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.40435470
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.35475476
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.14315535
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.04053015
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.03389300
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.92845007
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.78431355
13	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.76859257
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.52724627
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.51864515
16	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.45969327
17	DCP1A_22483619_ChIP-Seq_HELA_Human	2.44800650
18	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.33781812
19	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.31541419
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.26741695
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.26720127
22	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.25414171
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.13722489
24	XRN2_22483619_ChIP-Seq_HELA_Human	2.09881962
25	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.07300072
26	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.07289534
27	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.07140960
28	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.06608194
29	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.05664109
30	GABP_19822575_ChIP-Seq_HepG2_Human	2.03210070
31	TTF2_22483619_ChIP-Seq_HELA_Human	1.94935519
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.87869928
33	AR_21909140_ChIP-Seq_LNCAP_Human	1.87639260
34	TFEB_21752829_ChIP-Seq_HELA_Human	1.85039401
35	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.84879161
36	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.79841268
37	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.78845380
38	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.75008438
39	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.73658416
40	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.71999982
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.66979463
42	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.65200140
43	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.64945487
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.63897484
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.62613129
46	KDM5A_27292631_Chip-Seq_BREAST_Human	1.59692747
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.58738279
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57394649
49	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54795904
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.54766592
51	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.52648435
52	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51984428
53	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.43378212
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.43003222
55	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.42319337
56	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.38069241
57	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.34883353
58	ZNF263_19887448_ChIP-Seq_K562_Human	1.33581053
59	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.32803033
60	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.31062796
61	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.30237914
62	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.29079656
63	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.28952360
64	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.27202795
65	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.24012569
66	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.23138188
67	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23127751
68	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.22981379
69	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.22507083
70	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22109980
71	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20791805
72	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.20470985
73	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.18022515
74	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17480605
75	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.16674724
76	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.14214915
77	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.13487606
78	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.12201245
79	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.08994412
80	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.08926174
81	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.08451392
82	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.05416749
83	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.02678157
84	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.01028452
85	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.98773397
86	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.97892435
87	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.96626700
88	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.96524017
89	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.96003224
90	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94690593
91	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.93484936
92	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.93152341
93	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.91862833
94	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.91104569
95	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87063614
96	CIITA_25753668_ChIP-Seq_RAJI_Human	0.84952039
97	ATF3_27146783_Chip-Seq_COLON_Human	0.83390404
98	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.82152623
99	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.80258037
100	RBPJ_21746931_ChIP-Seq_IB4_Human	0.79394768

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009697_abnormal_copulation	4.28909537
2	MP0005360_urolithiasis	4.19888647
3	MP0003806_abnormal_nucleotide_metabolis	4.16421736
4	MP0003868_abnormal_feces_composition	3.78035550
5	MP0005058_abnormal_lysosome_morphology	3.53942389
6	MP0005085_abnormal_gallbladder_physiolo	3.51794947
7	MP0002138_abnormal_hepatobiliary_system	3.45997309
8	MP0002139_abnormal_hepatobiliary_system	3.39842053
9	MP0003693_abnormal_embryo_hatching	2.79780948
10	MP0005365_abnormal_bile_salt	2.76204477
11	MP0005171_absent_coat_pigmentation	2.74063722
12	MP0001661_extended_life_span	2.68318086
13	MP0009840_abnormal_foam_cell	2.66949084
14	MP0005408_hypopigmentation	2.56052384
15	MP0003252_abnormal_bile_duct	2.53357735
16	MP0005451_abnormal_body_composition	2.39303366
17	MP0004957_abnormal_blastocyst_morpholog	2.36804411
18	MP0003186_abnormal_redox_activity	2.35104914
19	MP0005410_abnormal_fertilization	2.27288855
20	MP0008875_abnormal_xenobiotic_pharmacok	2.26884711
21	MP0003136_yellow_coat_color	2.23435559
22	MP0003111_abnormal_nucleus_morphology	2.16472611
23	MP0003077_abnormal_cell_cycle	2.16318458
24	MP0003303_peritoneal_inflammation	2.12555583
25	MP0008058_abnormal_DNA_repair	1.91799217
26	MP0009333_abnormal_splenocyte_physiolog	1.89884148
27	MP0001666_abnormal_nutrient_absorption	1.88465182
28	MP0001764_abnormal_homeostasis	1.87677631
29	MP0006035_abnormal_mitochondrial_morpho	1.76825296
30	MP0003718_maternal_effect	1.75767397
31	MP0000358_abnormal_cell_content/	1.73793082
32	MP0001929_abnormal_gametogenesis	1.60525044
33	MP0010094_abnormal_chromosome_stability	1.57791748
34	MP0002210_abnormal_sex_determination	1.57238027
35	MP0006036_abnormal_mitochondrial_physio	1.55373585
36	MP0010386_abnormal_urinary_bladder	1.54620196
37	MP0008007_abnormal_cellular_replicative	1.50804373
38	MP0003698_abnormal_male_reproductive	1.40245284
39	MP0003786_premature_aging	1.37225866
40	MP0008932_abnormal_embryonic_tissue	1.36866290
41	MP0002090_abnormal_vision	1.33721559
42	MP0002160_abnormal_reproductive_system	1.26853651
43	MP0002132_abnormal_respiratory_system	1.25955923
44	MP0008260_abnormal_autophagy	1.25332442
45	MP0001145_abnormal_male_reproductive	1.24836041
46	MP0005395_other_phenotype	1.22482513
47	MP0000350_abnormal_cell_proliferation	1.18063460
48	MP0001730_embryonic_growth_arrest	1.16860937
49	MP0005332_abnormal_amino_acid	1.12883013
50	MP0002928_abnormal_bile_duct	1.11415000
51	MP0000609_abnormal_liver_physiology	1.11075361
52	MP0005389_reproductive_system_phenotype	1.11043098
53	MP0008995_early_reproductive_senescence	1.07952679
54	MP0000653_abnormal_sex_gland	1.07214805
55	MP0005319_abnormal_enzyme/_coenzyme	1.00692133
56	MP0000598_abnormal_liver_morphology	1.00355648
57	MP0001915_intracranial_hemorrhage	0.97025129
58	MP0002161_abnormal_fertility/fecundity	0.96025003
59	MP0010307_abnormal_tumor_latency	0.95420991
60	MP0003959_abnormal_lean_body	0.93043080
61	MP0001919_abnormal_reproductive_system	0.91591031
62	MP0002080_prenatal_lethality	0.90804970
63	MP0001697_abnormal_embryo_size	0.89482495
64	MP0003191_abnormal_cellular_cholesterol	0.88048671
65	MP0004019_abnormal_vitamin_homeostasis	0.82685229
66	MP0000313_abnormal_cell_death	0.82345658
67	MP0003195_calcinosis	0.79994218
68	MP0001529_abnormal_vocalization	0.79965375
69	MP0005384_cellular_phenotype	0.79244104
70	MP0005584_abnormal_enzyme/coenzyme_acti	0.77619166
71	MP0003950_abnormal_plasma_membrane	0.76482522
72	MP0002876_abnormal_thyroid_physiology	0.75643669
73	MP0000747_muscle_weakness	0.74244323
74	MP0009643_abnormal_urine_homeostasis	0.72797688
75	MP0009379_abnormal_foot_pigmentation	0.71823702
76	MP0002796_impaired_skin_barrier	0.71380293
77	MP0002089_abnormal_postnatal_growth/wei	0.69408540
78	MP0005501_abnormal_skin_physiology	0.69303592
79	MP0009672_abnormal_birth_weight	0.68359354
80	MP0005621_abnormal_cell_physiology	0.67074474
81	MP0004233_abnormal_muscle_weight	0.65727948
82	MP0010329_abnormal_lipoprotein_level	0.63624530
83	MP0002086_abnormal_extraembryonic_tissu	0.62393185
84	MP0000343_altered_response_to	0.61552130
85	MP0005174_abnormal_tail_pigmentation	0.59481098
86	MP0001348_abnormal_lacrimal_gland	0.59024169
87	MP0005636_abnormal_mineral_homeostasis	0.58494041
88	MP0005187_abnormal_penis_morphology	0.57948871
89	MP0005376_homeostasis/metabolism_phenot	0.57145514
90	MP0001186_pigmentation_phenotype	0.55587653
91	MP0003699_abnormal_female_reproductive	0.53978792
92	MP0003943_abnormal_hepatobiliary_system	0.53773772
93	MP0002084_abnormal_developmental_patter	0.53454130
94	MP0008004_abnormal_stomach_pH	0.53389442
95	MP0000490_abnormal_crypts_of	0.52736555
96	MP0005220_abnormal_exocrine_pancreas	0.52120040
97	MP0004808_abnormal_hematopoietic_stem	0.51819163
98	MP0002118_abnormal_lipid_homeostasis	0.51751181
99	MP0002269_muscular_atrophy	0.51262402
100	MP0010234_abnormal_vibrissa_follicle	0.51175092

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reduced antithrombin III activity (HP:0001976)	5.87888679
2	Deep venous thrombosis (HP:0002625)	4.46792741
3	Vertebral compression fractures (HP:0002953)	4.15139299
4	Prolonged partial thromboplastin time (HP:0003645)	3.90964726
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	3.80066553
6	Spastic paraparesis (HP:0002313)	3.74624183
7	Hypobetalipoproteinemia (HP:0003563)	3.67637265
8	Vacuolated lymphocytes (HP:0001922)	3.62147014
9	Cerebral hypomyelination (HP:0006808)	3.59595547
10	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.58166545
11	Abnormal protein N-linked glycosylation (HP:0012347)	3.58166545
12	Abnormal protein glycosylation (HP:0012346)	3.58166545
13	Abnormal glycosylation (HP:0012345)	3.58166545
14	Abnormality of pyrimidine metabolism (HP:0004353)	3.56633762
15	Abnormality of the intrinsic pathway (HP:0010989)	3.40007447
16	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.37416474
17	Type I transferrin isoform profile (HP:0003642)	3.34743021
18	Paraparesis (HP:0002385)	3.28351760
19	Hypokinesia (HP:0002375)	3.22158338
20	Patchy hypopigmentation of hair (HP:0011365)	3.07199575
21	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.95537744
22	Reticulocytopenia (HP:0001896)	2.94949707
23	Tetraparesis (HP:0002273)	2.78040057
24	Abnormal pupillary function (HP:0007686)	2.73998222
25	CNS hypomyelination (HP:0003429)	2.70962014
26	Cutaneous melanoma (HP:0012056)	2.69109633
27	Syringomyelia (HP:0003396)	2.68000140
28	Spinal cord lesions (HP:0100561)	2.68000140
29	Short nail (HP:0001799)	2.67079503
30	Abnormal tarsal ossification (HP:0008369)	2.64443602
31	Upper limb muscle weakness (HP:0003484)	2.58884107
32	Small epiphyses (HP:0010585)	2.58749397
33	Large for gestational age (HP:0001520)	2.58440700
34	Abnormality of methionine metabolism (HP:0010901)	2.58400948
35	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.48979765
36	Generalized aminoaciduria (HP:0002909)	2.48367206
37	Lower limb hyperreflexia (HP:0002395)	2.48177864
38	Self-mutilation (HP:0000742)	2.46087807
39	Abnormality of the distal phalanges of the toes (HP:0010182)	2.45117396
40	Abnormality of glycolipid metabolism (HP:0010969)	2.44800005
41	Abnormality of liposaccharide metabolism (HP:0010968)	2.44800005
42	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.44800005
43	Ependymoma (HP:0002888)	2.42150603
44	Mitral stenosis (HP:0001718)	2.40902666
45	Epiphyseal stippling (HP:0010655)	2.40315719
46	Progressive external ophthalmoplegia (HP:0000590)	2.38304813
47	Male infertility (HP:0003251)	2.37897753
48	Thoracic kyphosis (HP:0002942)	2.34579006
49	Carpal bone hypoplasia (HP:0001498)	2.32259640
50	Tinnitus (HP:0000360)	2.30285426
51	Hypoplasia of the uterus (HP:0000013)	2.28654939
52	Abnormal gallbladder physiology (HP:0012438)	2.24710759
53	Cholecystitis (HP:0001082)	2.24710759
54	Hyperammonemia (HP:0001987)	2.23313486
55	Entropion (HP:0000621)	2.22932586
56	Sparse eyelashes (HP:0000653)	2.21873900
57	White forelock (HP:0002211)	2.18949077
58	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.18415296
59	Prolonged neonatal jaundice (HP:0006579)	2.16040291
60	Hypolipoproteinemia (HP:0010981)	2.11433245
61	Beaking of vertebral bodies (HP:0004568)	2.10884968
62	Flattened epiphyses (HP:0003071)	2.09085605
63	Abnormal foot bone ossification (HP:0010675)	2.05758291
64	Osteolytic defects of the hand bones (HP:0009699)	2.05516091
65	Osteolytic defects of the phalanges of the hand (HP:0009771)	2.05516091
66	Proximal tubulopathy (HP:0000114)	2.04585169
67	Overlapping toe (HP:0001845)	2.04455985
68	Posterior subcapsular cataract (HP:0007787)	2.04435192
69	Elevated alkaline phosphatase (HP:0003155)	2.04225166
70	Abnormality of cells of the erythroid lineage (HP:0012130)	2.03983329
71	Abnormal spermatogenesis (HP:0008669)	2.02386984
72	Neoplasm of the peripheral nervous system (HP:0100007)	2.00478595
73	Acute encephalopathy (HP:0006846)	1.99380224
74	Albinism (HP:0001022)	1.98265612
75	Aplasia/hypoplasia of the uterus (HP:0008684)	1.98047161
76	Abnormality of the thoracic spine (HP:0100711)	1.95770498
77	Decreased subcutaneous fat (HP:0001002)	1.94160777
78	Abnormality of the preputium (HP:0100587)	1.92672076
79	Abnormality of the lumbar spine (HP:0100712)	1.90986885
80	Abnormality of fatty-acid metabolism (HP:0004359)	1.90020093
81	Abnormal number of erythroid precursors (HP:0012131)	1.88052986
82	Conjugated hyperbilirubinemia (HP:0002908)	1.87483948
83	Abnormal auditory evoked potentials (HP:0006958)	1.87224610
84	Opisthotonus (HP:0002179)	1.85640516
85	Intrahepatic cholestasis (HP:0001406)	1.83244451
86	Abnormality of alkaline phosphatase activity (HP:0004379)	1.81679315
87	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.81601285
88	Hyperlipoproteinemia (HP:0010980)	1.79031934
89	Ureteral duplication (HP:0000073)	1.78167931
90	Cerebral edema (HP:0002181)	1.77337449
91	Abnormality of the Achilles tendon (HP:0005109)	1.76581467
92	Brushfield spots (HP:0001088)	1.76217023
93	Achilles tendon contracture (HP:0001771)	1.75734049
94	Acute necrotizing encephalopathy (HP:0006965)	1.75083485
95	Abnormal epiphyseal ossification (HP:0010656)	1.74375751
96	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.74216617
97	Abnormality of subcutaneous fat tissue (HP:0001001)	1.72549151
98	Abnormal enzyme/coenzyme activity (HP:0012379)	1.72387017
99	Facial hemangioma (HP:0000329)	1.72187610
100	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.72001051

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	4.80273297
2	PBK	4.76655469
3	NME2	4.29106829
4	PRPF4B	3.99325608
5	IRAK3	3.97619877
6	NEK1	3.22348187
7	ARAF	2.54722745
8	BUB1	2.53069977
9	LMTK2	2.50308219
10	TAOK2	2.43093574
11	EIF2AK1	2.27713729
12	SCYL2	2.10710031
13	PAK6	1.99787911
14	STK16	1.99631437
15	MARK3	1.98482293
16	MET	1.93795165
17	BRAF	1.90491314
18	PINK1	1.89005913
19	ZAK	1.84403373
20	GRK7	1.62342139
21	KSR2	1.57824362
22	MAP3K9	1.57092898
23	SRPK1	1.49253007
24	CDK19	1.46772889
25	IRAK2	1.41659076
26	TESK2	1.38538350
27	NEK2	1.38341832
28	TLK1	1.38179761
29	PAK4	1.25627775
30	TSSK6	1.25086282
31	MOS	1.23241414
32	BRSK1	1.21361064
33	MST4	1.14662385
34	EPHA2	1.10644395
35	TTK	1.00218274
36	MST1R	0.98749429
37	PDK2	0.98160392
38	CDK8	0.90893746
39	WEE1	0.88282085
40	PAK1	0.88059031
41	BMX	0.87348578
42	PAK2	0.87031657
43	RAF1	0.86378576
44	IRAK4	0.84891346
45	KSR1	0.84249618
46	MAP3K8	0.83727712
47	AKT2	0.82386985
48	PRKCI	0.81448174
49	ERN1	0.79981316
50	RPS6KA5	0.79318535
51	PLK1	0.74796147
52	ILK	0.74502487
53	STK10	0.72126083
54	LRRK2	0.71633177
55	AURKA	0.71095984
56	CDK3	0.70902556
57	TESK1	0.63810554
58	FLT3	0.60726227
59	CCNB1	0.59274961
60	MAP3K13	0.57949692
61	PIM2	0.56664789
62	STK4	0.54698166
63	CLK1	0.52516297
64	AURKB	0.50522318
65	ERBB4	0.50475296
66	PLK4	0.48893566
67	CHEK2	0.47740673
68	CDK14	0.46168725
69	MAP3K12	0.42589905
70	PDPK1	0.42028154
71	CDK11A	0.41986097
72	CDK7	0.41308546
73	MAP3K5	0.39482345
74	CHEK1	0.39235519
75	TBK1	0.38889612
76	PKN1	0.37272375
77	PLK3	0.36732684
78	ABL2	0.36682274
79	RPS6KB2	0.35985747
80	MYLK	0.35714483
81	CSNK2A1	0.35593054
82	DAPK3	0.34798450
83	OXSR1	0.33549627
84	BRSK2	0.33393106
85	CDK15	0.32858959
86	IRAK1	0.32164973
87	CDK18	0.31575608
88	MELK	0.31106035
89	CSNK2A2	0.28956141
90	MAP3K1	0.28463180
91	DYRK3	0.27461254
92	ATM	0.26964407
93	EEF2K	0.26422146
94	MUSK	0.26230873
95	BMPR2	0.26062013
96	CDC7	0.25848416
97	ZAP70	0.25842208
98	BMPR1B	0.25472359
99	RPS6KB1	0.24381660
100	NME1	0.22663931

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.09720249
2	Proteasome_Homo sapiens_hsa03050	2.96226180
3	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.90835717
4	Ribosome_Homo sapiens_hsa03010	2.87496605
5	Sulfur relay system_Homo sapiens_hsa04122	2.85829634
6	DNA replication_Homo sapiens_hsa03030	2.42211764
7	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.34145721
8	Sulfur metabolism_Homo sapiens_hsa00920	2.30561007
9	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.14737071
10	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.09855315
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.06868602
12	Arginine biosynthesis_Homo sapiens_hsa00220	1.98586408
13	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.98397399
14	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.82444219
15	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.75481826
16	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.74630061
17	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.73114501
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.71145259
19	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.69535993
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.68709968
21	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.65265349
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.58161871
23	RNA polymerase_Homo sapiens_hsa03020	1.57025607
24	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.55193899
25	One carbon pool by folate_Homo sapiens_hsa00670	1.55060209
26	Mismatch repair_Homo sapiens_hsa03430	1.54746510
27	Complement and coagulation cascades_Homo sapiens_hsa04610	1.53785396
28	Phenylalanine metabolism_Homo sapiens_hsa00360	1.53778984
29	Base excision repair_Homo sapiens_hsa03410	1.47417246
30	Carbon metabolism_Homo sapiens_hsa01200	1.46632210
31	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.43927122
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.42707424
33	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.41859339
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.39804205
35	Pentose phosphate pathway_Homo sapiens_hsa00030	1.38892560
36	Fatty acid elongation_Homo sapiens_hsa00062	1.33956059
37	Retinol metabolism_Homo sapiens_hsa00830	1.31991654
38	Peroxisome_Homo sapiens_hsa04146	1.31716430
39	RNA transport_Homo sapiens_hsa03013	1.31693090
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.26514874
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.23016190
42	Prion diseases_Homo sapiens_hsa05020	1.22870068
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.22676055
44	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.22610525
45	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.20999449
46	Parkinsons disease_Homo sapiens_hsa05012	1.18543549
47	Nucleotide excision repair_Homo sapiens_hsa03420	1.16440932
48	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.12144796
49	Folate biosynthesis_Homo sapiens_hsa00790	1.11564356
50	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.10055111
51	Oxidative phosphorylation_Homo sapiens_hsa00190	1.07579261
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.06279162
53	Tyrosine metabolism_Homo sapiens_hsa00350	1.06245238
54	Chemical carcinogenesis_Homo sapiens_hsa05204	1.02643595
55	Other glycan degradation_Homo sapiens_hsa00511	0.97356512
56	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.94238314
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.93202793
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92769491
59	Alcoholism_Homo sapiens_hsa05034	0.89376679
60	Protein export_Homo sapiens_hsa03060	0.86671167
61	Non-homologous end-joining_Homo sapiens_hsa03450	0.86496031
62	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86099801
63	Glutathione metabolism_Homo sapiens_hsa00480	0.84611028
64	Huntingtons disease_Homo sapiens_hsa05016	0.84519150
65	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.82659507
66	Cell cycle_Homo sapiens_hsa04110	0.80511504
67	Metabolic pathways_Homo sapiens_hsa01100	0.78973853
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.77714060
69	Purine metabolism_Homo sapiens_hsa00230	0.73691469
70	Vibrio cholerae infection_Homo sapiens_hsa05110	0.73078746
71	Bile secretion_Homo sapiens_hsa04976	0.72360719
72	Homologous recombination_Homo sapiens_hsa03440	0.71999924
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67402743
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.66564600
75	Apoptosis_Homo sapiens_hsa04210	0.63042745
76	Galactose metabolism_Homo sapiens_hsa00052	0.63014900
77	Basal transcription factors_Homo sapiens_hsa03022	0.61608999
78	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.59347790
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58780852
80	Lysosome_Homo sapiens_hsa04142	0.57217275
81	Spliceosome_Homo sapiens_hsa03040	0.57000513
82	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.56531763
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56034499
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.52703547
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.49221453
86	mRNA surveillance pathway_Homo sapiens_hsa03015	0.49215931
87	p53 signaling pathway_Homo sapiens_hsa04115	0.44554311
88	Alzheimers disease_Homo sapiens_hsa05010	0.43721395
89	Steroid biosynthesis_Homo sapiens_hsa00100	0.42858227
90	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41352314
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.41048083
92	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40528742
93	Histidine metabolism_Homo sapiens_hsa00340	0.39366916
94	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.38204894
95	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.37861990
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37555898
97	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33522630
98	Viral carcinogenesis_Homo sapiens_hsa05203	0.30754050
99	Propanoate metabolism_Homo sapiens_hsa00640	0.29549598
100	Collecting duct acid secretion_Homo sapiens_hsa04966	0.27621044

PAGE2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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