ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis I (GO:0007141)	9.97764516
2	synaptonemal complex assembly (GO:0007130)	9.48993804
3	piRNA metabolic process (GO:0034587)	9.18270660
4	DNA synthesis involved in DNA repair (GO:0000731)	8.51073744
5	synaptonemal complex organization (GO:0070193)	8.47635653
6	meiosis I (GO:0007127)	8.21852051
7	meiotic nuclear division (GO:0007126)	8.09471861
8	DNA methylation involved in gamete generation (GO:0043046)	7.62674748
9	meiotic cell cycle process (GO:1903046)	6.22114730
10	sister chromatid cohesion (GO:0007062)	5.67622429
11	resolution of meiotic recombination intermediates (GO:0000712)	5.17246850
12	meiotic chromosome segregation (GO:0045132)	5.03135195
13	regulation of meiosis I (GO:0060631)	4.85168799
14	histone H3-K9 demethylation (GO:0033169)	4.82145092
15	binding of sperm to zona pellucida (GO:0007339)	4.78638414
16	sex differentiation (GO:0007548)	4.66075966
17	reciprocal DNA recombination (GO:0035825)	4.46727084
18	reciprocal meiotic recombination (GO:0007131)	4.46727084
19	spermatid development (GO:0007286)	4.14790471
20	histone exchange (GO:0043486)	4.11981638
21	nucleosome assembly (GO:0006334)	4.06267210
22	gene silencing by RNA (GO:0031047)	4.01562603
23	histone H3-K36 demethylation (GO:0070544)	3.86665894
24	mitotic chromosome condensation (GO:0007076)	3.83666486
25	nuclear pore complex assembly (GO:0051292)	3.75894146
26	nucleosome organization (GO:0034728)	3.63722696
27	protein-DNA complex assembly (GO:0065004)	3.57670190
28	mesoderm development (GO:0007498)	3.56105751
29	sperm-egg recognition (GO:0035036)	3.52659657
30	diterpenoid biosynthetic process (GO:0016102)	3.50347957
31	regulation of oxidative stress-induced neuron death (GO:1903203)	3.44513138
32	acrosome reaction (GO:0007340)	3.39542405
33	mitotic sister chromatid cohesion (GO:0007064)	3.37277554
34	female gamete generation (GO:0007292)	3.33688284
35	DNA replication initiation (GO:0006270)	3.32817741
36	chromosome organization (GO:0051276)	3.31862237
37	protein-DNA complex subunit organization (GO:0071824)	3.28750250
38	mitotic metaphase plate congression (GO:0007080)	3.18604189
39	proteasome assembly (GO:0043248)	3.16467583
40	oogenesis (GO:0048477)	3.15323524
41	nuclear pore organization (GO:0006999)	3.06181566
42	DNA alkylation (GO:0006305)	3.05371862
43	DNA methylation (GO:0006306)	3.05371862
44	negative regulation of inclusion body assembly (GO:0090084)	3.04627441
45	potassium ion export (GO:0071435)	3.04015187
46	regulation of DNA endoreduplication (GO:0032875)	3.03651121
47	male gamete generation (GO:0048232)	3.02343636
48	spermatogenesis (GO:0007283)	3.02265867
49	mesenchyme development (GO:0060485)	3.02096714
50	gonadal mesoderm development (GO:0007506)	23.7279082
51	regulation of oxidative phosphorylation (GO:0002082)	2.99761983
52	positive regulation of response to oxidative stress (GO:1902884)	2.98051807
53	positive regulation of cellular response to oxidative stress (GO:1900409)	2.98051807
54	protein localization to chromosome (GO:0034502)	2.96268492
55	DNA biosynthetic process (GO:0071897)	2.93754430
56	germ cell development (GO:0007281)	2.92485923
57	attachment of spindle microtubules to kinetochore (GO:0008608)	2.92060522
58	nuclear division (GO:0000280)	2.91793173
59	gamete generation (GO:0007276)	2.90387022
60	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.87539497
61	cell-cell recognition (GO:0009988)	2.86880287
62	mitotic spindle checkpoint (GO:0071174)	2.83088613
63	pore complex assembly (GO:0046931)	2.82776758
64	mitotic spindle assembly checkpoint (GO:0007094)	2.82750836
65	spindle checkpoint (GO:0031577)	2.77761787
66	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.77249601
67	organelle fission (GO:0048285)	2.75893421
68	ribosomal small subunit biogenesis (GO:0042274)	2.75263212
69	spindle assembly checkpoint (GO:0071173)	2.74935607
70	meiotic cell cycle (GO:0051321)	2.73634611
71	fertilization (GO:0009566)	2.72787237
72	DNA packaging (GO:0006323)	2.71792481
73	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.69467702
74	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.69467702
75	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.69467702
76	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.69467702
77	negative regulation of sister chromatid segregation (GO:0033046)	2.69467702
78	sperm motility (GO:0030317)	2.69017064
79	regulation of chromosome segregation (GO:0051983)	2.68424140
80	negative regulation of chromosome segregation (GO:0051985)	2.68420885
81	mitotic sister chromatid segregation (GO:0000070)	2.68071597
82	motile cilium assembly (GO:0044458)	2.66981805
83	de novo posttranslational protein folding (GO:0051084)	2.66397790
84	regulation of meiotic cell cycle (GO:0051445)	2.65737454
85	regulation of histone H3-K9 methylation (GO:0051570)	2.62902535
86	regulation of hydrogen peroxide-induced cell death (GO:1903205)	2.62808964
87	polyamine biosynthetic process (GO:0006596)	2.59662148
88	metaphase plate congression (GO:0051310)	2.59584287
89	CENP-A containing nucleosome assembly (GO:0034080)	2.56885031
90	de novo protein folding (GO:0006458)	2.55564950
91	mitotic nuclear envelope disassembly (GO:0007077)	2.55285096
92	telomere maintenance via semi-conservative replication (GO:0032201)	2.53275226
93	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.50223850
94	ATP-dependent chromatin remodeling (GO:0043044)	2.49202662
95	mitochondrion degradation (GO:0000422)	2.48882894
96	chromosome segregation (GO:0007059)	2.47355928
97	cellular process involved in reproduction in multicellular organism (GO:0022412)	2.45647919
98	synapsis (GO:0007129)	13.1193999
99	chromosome organization involved in meiosis (GO:0070192)	10.7371436
100	male meiosis (GO:0007140)	10.3501810

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.06730383
2	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	4.99629404
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.01986272
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.70577166
5	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.55810195
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.17598504
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.13111810
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.94417965
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.93607426
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.78732300
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.75922632
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.70327184
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.62547657
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.56559466
15	DCP1A_22483619_ChIP-Seq_HELA_Human	2.54924116
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.36937798
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.34505605
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.34047652
19	GABP_19822575_ChIP-Seq_HepG2_Human	2.15051461
20	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	2.09693539
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08388204
22	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	2.07422141
23	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.05122260
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.03102166
25	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.92810109
26	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.92134881
27	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.87320362
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.78877612
29	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.78668119
30	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.76972547
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.76346861
32	XRN2_22483619_ChIP-Seq_HELA_Human	1.75560189
33	KDM5A_27292631_Chip-Seq_BREAST_Human	1.75155793
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.74891924
35	AR_21909140_ChIP-Seq_LNCAP_Human	1.74789089
36	TTF2_22483619_ChIP-Seq_HELA_Human	1.72005282
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.69911435
38	ZNF263_19887448_ChIP-Seq_K562_Human	1.65108866
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.62774613
40	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.62144096
41	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.59105714
42	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.58326257
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51180525
44	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.47874070
45	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.42659879
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.41824972
47	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.40236046
48	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.39856052
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.39443916
50	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.34790270
51	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.34267584
52	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.33640734
53	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28031122
54	ERA_21632823_ChIP-Seq_H3396_Human	1.26491147
55	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.25590539
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.22537123
57	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.21139227
58	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20291551
59	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.19941987
60	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.19844432
61	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.19423828
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.19142027
63	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18272473
64	TFEB_21752829_ChIP-Seq_HELA_Human	1.16685881
65	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.15472422
66	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.14383409
67	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.08431428
68	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.06732332
69	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.05062803
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.01548717
71	RAC3_21632823_ChIP-Seq_H3396_Human	1.01489461
72	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01270645
73	ELK1_19687146_ChIP-ChIP_HELA_Human	1.00645279
74	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.99867053
75	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.98981866
76	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.98608815
77	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.98531942
78	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.98387850
79	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.96507982
80	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95773091
81	PHF8_20622854_ChIP-Seq_HELA_Human	0.95526403
82	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.93616371
83	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.93462119
84	SMC4_20622854_ChIP-Seq_HELA_Human	0.92930286
85	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.91462740
86	PHF8_20622853_ChIP-Seq_HELA_Human	0.91462098
87	P68_20966046_ChIP-Seq_HELA_Human	0.91386869
88	EGR1_19374776_ChIP-ChIP_THP-1_Human	0.90758633
89	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.88866567
90	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.87187260
91	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.87031558
92	ER_23166858_ChIP-Seq_MCF-7_Human	0.86507461
93	TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse	0.86006015
94	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.85352479
95	ETV1_20927104_ChIP-Seq_GIST48_Human	0.85236752
96	NCOR1_26117541_ChIP-Seq_K562_Human	0.84893256
97	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.84737540
98	CIITA_25753668_ChIP-Seq_RAJI_Human	0.84281121
99	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.84041396
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.82113852

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.88308994
2	MP0008058_abnormal_DNA_repair	4.26586924
3	MP0002210_abnormal_sex_determination	4.24797784
4	MP0001929_abnormal_gametogenesis	4.10862212
5	MP0005410_abnormal_fertilization	3.99462042
6	MP0002160_abnormal_reproductive_system	3.65618099
7	MP0003698_abnormal_male_reproductive	3.54277003
8	MP0008004_abnormal_stomach_pH	3.28781853
9	MP0001145_abnormal_male_reproductive	3.23757918
10	MP0008995_early_reproductive_senescence	3.21850789
11	MP0003693_abnormal_embryo_hatching	3.21749146
12	MP0005058_abnormal_lysosome_morphology	2.95648074
13	MP0000653_abnormal_sex_gland	2.90295610
14	MP0003111_abnormal_nucleus_morphology	2.66713701
15	MP0004957_abnormal_blastocyst_morpholog	2.58552825
16	MP0010094_abnormal_chromosome_stability	2.33472753
17	MP0005389_reproductive_system_phenotype	2.31214605
18	MP0003077_abnormal_cell_cycle	2.21124108
19	MP0003718_maternal_effect	2.16406870
20	MP0000678_abnormal_parathyroid_gland	2.15454376
21	MP0006035_abnormal_mitochondrial_morpho	2.10289992
22	MP0002161_abnormal_fertility/fecundity	2.05546932
23	MP0002132_abnormal_respiratory_system	1.99616349
24	MP0005451_abnormal_body_composition	1.95212118
25	MP0006036_abnormal_mitochondrial_physio	1.90781784
26	MP0009697_abnormal_copulation	1.83488172
27	MP0003786_premature_aging	1.79234198
28	MP0001661_extended_life_span	1.75353845
29	MP0008260_abnormal_autophagy	1.73312477
30	MP0008007_abnormal_cellular_replicative	1.71924241
31	MP0003315_abnormal_perineum_morphology	1.68676183
32	MP0003646_muscle_fatigue	1.64845446
33	MP0001119_abnormal_female_reproductive	1.62650177
34	MP0003699_abnormal_female_reproductive	1.51060321
35	MP0003136_yellow_coat_color	1.45606254
36	MP0005360_urolithiasis	1.37535831
37	MP0003806_abnormal_nucleotide_metabolis	1.37321429
38	MP0001730_embryonic_growth_arrest	1.35520224
39	MP0000358_abnormal_cell_content/	1.35400543
40	MP0000015_abnormal_ear_pigmentation	1.31848950
41	MP0008932_abnormal_embryonic_tissue	1.27215542
42	MP0005174_abnormal_tail_pigmentation	1.26681826
43	MP0001529_abnormal_vocalization	1.22761480
44	MP0008057_abnormal_DNA_replication	1.21145478
45	MP0003186_abnormal_redox_activity	1.19344976
46	MP0009333_abnormal_splenocyte_physiolog	1.17854625
47	MP0005395_other_phenotype	1.15744881
48	MP0001697_abnormal_embryo_size	1.12929739
49	MP0010307_abnormal_tumor_latency	1.10980888
50	MP0001919_abnormal_reproductive_system	1.09351223
51	MP0005394_taste/olfaction_phenotype	1.04187630
52	MP0005499_abnormal_olfactory_system	1.04187630
53	MP0000350_abnormal_cell_proliferation	1.02916454
54	MP0002080_prenatal_lethality	1.02498850
55	MP0000313_abnormal_cell_death	1.01619837
56	MP0009379_abnormal_foot_pigmentation	1.01337836
57	MP0003656_abnormal_erythrocyte_physiolo	0.99878262
58	MP0008789_abnormal_olfactory_epithelium	0.97698678
59	MP0005647_abnormal_sex_gland	0.97303821
60	MP0001672_abnormal_embryogenesis/_devel	0.90566956
61	MP0005380_embryogenesis_phenotype	0.90566956
62	MP0001764_abnormal_homeostasis	0.87922273
63	MP0002084_abnormal_developmental_patter	0.86949538
64	MP0002139_abnormal_hepatobiliary_system	0.85232671
65	MP0003936_abnormal_reproductive_system	0.83858866
66	MP0002095_abnormal_skin_pigmentation	0.83583667
67	MP0001986_abnormal_taste_sensitivity	0.83519691
68	MP0003984_embryonic_growth_retardation	0.77063384
69	MP0002088_abnormal_embryonic_growth/wei	0.74175864
70	MP0004808_abnormal_hematopoietic_stem	0.73748474
71	MP0002086_abnormal_extraembryonic_tissu	0.72230741
72	MP0002085_abnormal_embryonic_tissue	0.69589891
73	MP0000490_abnormal_crypts_of	0.68202392
74	MP0001664_abnormal_digestion	0.67884828
75	MP0001188_hyperpigmentation	0.67874213
76	MP0003943_abnormal_hepatobiliary_system	0.67496525
77	MP0004147_increased_porphyrin_level	0.67487932
78	MP0002138_abnormal_hepatobiliary_system	0.66736803
79	MP0002269_muscular_atrophy	0.63941516
80	MP0003303_peritoneal_inflammation	0.62141886
81	MP0001984_abnormal_olfaction	0.60759575
82	MP0001915_intracranial_hemorrhage	0.59083688
83	MP0005636_abnormal_mineral_homeostasis	0.57746546
84	MP0005384_cellular_phenotype	0.57609186
85	MP0003123_paternal_imprinting	0.56435894
86	MP0000569_abnormal_digit_pigmentation	0.56000175
87	MP0001666_abnormal_nutrient_absorption	0.54610424
88	MP0004019_abnormal_vitamin_homeostasis	0.53830641
89	MP0009703_decreased_birth_body	0.53214491
90	MP0000703_abnormal_thymus_morphology	0.52215473
91	MP0005085_abnormal_gallbladder_physiolo	0.52073240
92	MP0003868_abnormal_feces_composition	0.49054949
93	MP0002928_abnormal_bile_duct	0.48887032
94	MP0005365_abnormal_bile_salt	0.48325464
95	MP0001545_abnormal_hematopoietic_system	0.47475375
96	MP0005397_hematopoietic_system_phenotyp	0.47475375
97	MP0003937_abnormal_limbs/digits/tail_de	0.47004827
98	MP0002796_impaired_skin_barrier	0.45096765
99	MP0009840_abnormal_foam_cell	0.44822106
100	MP0010386_abnormal_urinary_bladder	0.44110032

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Azoospermia (HP:0000027)	4.39455167
2	Facial hemangioma (HP:0000329)	4.09588565
3	Resting tremor (HP:0002322)	4.02907471
4	Hypoplasia of the uterus (HP:0000013)	3.92629348
5	Volvulus (HP:0002580)	3.88892901
6	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.63929893
7	Abnormal protein N-linked glycosylation (HP:0012347)	3.63929893
8	Abnormal protein glycosylation (HP:0012346)	3.63929893
9	Abnormal glycosylation (HP:0012345)	3.63929893
10	Spontaneous abortion (HP:0005268)	3.52029133
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.51765245
12	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.49636356
13	Gonadotropin excess (HP:0000837)	3.49087128
14	Abnormal spermatogenesis (HP:0008669)	3.48679014
15	Reduced antithrombin III activity (HP:0001976)	3.47722030
16	Ileus (HP:0002595)	3.38392913
17	Chromsome breakage (HP:0040012)	3.37648530
18	Tubulointerstitial nephritis (HP:0001970)	3.29655234
19	Male infertility (HP:0003251)	3.25539408
20	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.16840237
21	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.16840237
22	Infertility (HP:0000789)	3.05358862
23	Type I transferrin isoform profile (HP:0003642)	3.05350789
24	Capillary hemangiomas (HP:0005306)	2.99000168
25	Aplasia/hypoplasia of the uterus (HP:0008684)	2.86424225
26	Oligodactyly (hands) (HP:0001180)	2.80484547
27	Shoulder girdle muscle weakness (HP:0003547)	2.77155076
28	Reticulocytopenia (HP:0001896)	2.76611361
29	Urinary urgency (HP:0000012)	2.73649410
30	Osteomalacia (HP:0002749)	2.70429992
31	Ectopic kidney (HP:0000086)	2.69334947
32	Thoracic kyphosis (HP:0002942)	2.66999146
33	Abnormality of DNA repair (HP:0003254)	2.66683139
34	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.60174771
35	Small intestinal stenosis (HP:0012848)	2.58252800
36	Duodenal stenosis (HP:0100867)	2.58252800
37	Truncus arteriosus (HP:0001660)	2.57440202
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.53654920
39	Increased nuchal translucency (HP:0010880)	2.48990402
40	Progressive external ophthalmoplegia (HP:0000590)	2.48361630
41	Abnormality of the preputium (HP:0100587)	2.46752988
42	Absent thumb (HP:0009777)	2.44803096
43	Abnormality of the lumbar spine (HP:0100712)	2.41153638
44	Abnormality of the columella (HP:0009929)	2.37622098
45	Flattened epiphyses (HP:0003071)	2.35984199
46	Abnormality of cochlea (HP:0000375)	2.34819697
47	Abnormality of reticulocytes (HP:0004312)	2.34760580
48	Metaphyseal cupping (HP:0003021)	2.34709820
49	Duplicated collecting system (HP:0000081)	2.30959840
50	Horizontal nystagmus (HP:0000666)	2.30734804
51	Oligodactyly (HP:0012165)	2.27929741
52	Ventricular fibrillation (HP:0001663)	2.27356027
53	Abnormality of the renal collecting system (HP:0004742)	2.27118905
54	Ureteral duplication (HP:0000073)	2.26714064
55	Absent/shortened dynein arms (HP:0200106)	2.24753368
56	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24753368
57	Gonadal dysgenesis (HP:0000133)	2.19948219
58	11 pairs of ribs (HP:0000878)	2.19857622
59	Abnormal hemoglobin (HP:0011902)	2.18870487
60	Abnormality of the ileum (HP:0001549)	2.17561975
61	Short nail (HP:0001799)	2.16526080
62	Broad distal phalanx of finger (HP:0009836)	2.15973968
63	Rimmed vacuoles (HP:0003805)	2.15641841
64	Reticulocytosis (HP:0001923)	2.14936525
65	Abnormal lung lobation (HP:0002101)	2.14421864
66	Poikilocytosis (HP:0004447)	2.13763453
67	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.13700827
68	Meckel diverticulum (HP:0002245)	2.13406106
69	Abnormality of the thoracic spine (HP:0100711)	2.13014353
70	Cerebral hypomyelination (HP:0006808)	2.12774801
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.12681087
72	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.12681087
73	Proximal placement of thumb (HP:0009623)	2.12051930
74	Hypergonadotropic hypogonadism (HP:0000815)	2.11531940
75	Abnormality of the intrinsic pathway (HP:0010989)	2.08851321
76	Self-mutilation (HP:0000742)	2.07841583
77	Pallor (HP:0000980)	2.06668130
78	Abnormality of pyrimidine metabolism (HP:0004353)	2.05575387
79	Premature ovarian failure (HP:0008209)	2.04591018
80	Horseshoe kidney (HP:0000085)	2.03817036
81	Abnormal respiratory motile cilium physiology (HP:0012261)	2.03794748
82	Myelodysplasia (HP:0002863)	2.03676338
83	Abnormality of the corticospinal tract (HP:0002492)	2.03228460
84	Abnormal sex determination (HP:0012244)	2.02585369
85	Sex reversal (HP:0012245)	2.02585369
86	Urethral obstruction (HP:0000796)	2.02101000
87	Duplication of thumb phalanx (HP:0009942)	1.99832706
88	Squamous cell carcinoma (HP:0002860)	1.99008107
89	Ependymoma (HP:0002888)	1.94014933
90	Acanthocytosis (HP:0001927)	1.93927594
91	Abnormality of chromosome stability (HP:0003220)	1.93094724
92	Abnormality of the tricuspid valve (HP:0001702)	1.92863217
93	Type II lissencephaly (HP:0007260)	1.90170290
94	Basal cell carcinoma (HP:0002671)	1.90097153
95	Postural instability (HP:0002172)	1.89930599
96	Abnormality of the duodenum (HP:0002246)	1.89317167
97	Deviation of the thumb (HP:0009603)	1.86313095
98	Ankyloglossia (HP:0010296)	1.85157775
99	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.84253986
100	Long foot (HP:0001833)	1.81437205

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.56740885
2	MARK3	3.90855622
3	PNCK	3.68507520
4	CDK19	3.53487407
5	PDK2	3.15981725
6	PBK	2.95376563
7	ZAK	2.81197778
8	NEK2	2.47400954
9	KSR2	2.40930807
10	MET	2.27537680
11	EIF2AK3	2.25425197
12	TLK1	2.22080392
13	BMX	2.22014410
14	PRPF4B	2.18206752
15	EIF2AK1	2.10091854
16	TTK	2.07615171
17	BUB1	1.97752790
18	BRAF	1.90404014
19	NEK1	1.81704529
20	PLK4	1.75810283
21	STK16	1.70129219
22	MAP3K2	1.69926845
23	FGR	1.63431313
24	PLK1	1.55340618
25	RPS6KA5	1.51399593
26	NME2	1.44773106
27	KSR1	1.42011794
28	TAOK2	1.36097077
29	ARAF	1.34239328
30	WEE1	1.32942417
31	RAF1	1.29077312
32	SRPK1	1.25281729
33	CCNB1	1.23080927
34	CDK3	1.22565777
35	PTK2B	1.15521797
36	AURKA	1.11319360
37	STK38	1.08620863
38	MAP3K9	1.05304396
39	IRAK3	1.05029808
40	BRSK1	1.02663940
41	OXSR1	0.99726303
42	MAP3K13	0.96169456
43	CHEK1	0.93577783
44	RET	0.90807072
45	MYLK	0.90594491
46	MAP3K8	0.87543193
47	ATR	0.85377038
48	IRAK2	0.84637496
49	ATM	0.83432414
50	MAP3K1	0.82444804
51	DYRK3	0.77438316
52	NTRK3	0.77080329
53	PAK1	0.75701694
54	RPS6KB1	0.75336329
55	MAP3K5	0.75282571
56	CHEK2	0.72934786
57	PRKCI	0.71100466
58	STK38L	0.71011475
59	CLK1	0.70176632
60	SCYL2	0.67295592
61	STK4	0.63350802
62	AKT2	0.62202451
63	VRK1	0.61778080
64	AURKB	0.59841796
65	MST1R	0.59418494
66	BRSK2	0.58736065
67	MST4	0.57973964
68	CSF1R	0.53144922
69	PIM1	0.52807094
70	PDPK1	0.51779586
71	MAP3K10	0.51628982
72	CDK8	0.51394311
73	PLK3	0.51159764
74	CDK14	0.50812486
75	CDK1	0.47620413
76	TESK2	0.46574281
77	AKT3	0.43615558
78	CSNK2A1	0.43096849
79	PLK2	0.41292103
80	LATS1	0.41174573
81	EGFR	0.40968388
82	SGK1	0.39971998
83	CDC7	0.39845920
84	CSNK2A2	0.39475390
85	CAMK1G	0.39107043
86	CDK2	0.38725126
87	CDK11A	0.37327507
88	TSSK6	0.36988722
89	STK10	0.36960483
90	CDK4	0.34993885
91	PDK1	0.34724147
92	NEK9	0.34194001
93	MAP3K4	0.34072885
94	MOS	0.33233725
95	PRKCQ	0.30515327
96	MELK	0.30352486
97	CDK7	0.30098938
98	PAK6	0.29986801
99	LMTK2	0.29958530
100	STK3	0.29004367

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	3.86621741
2	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	3.17693065
3	Mismatch repair_Homo sapiens_hsa03430	3.07954195
4	Homologous recombination_Homo sapiens_hsa03440	3.07363119
5	RNA transport_Homo sapiens_hsa03013	3.03273901
6	Sulfur relay system_Homo sapiens_hsa04122	2.67288739
7	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.66292877
8	Cell cycle_Homo sapiens_hsa04110	2.59445566
9	Ribosome_Homo sapiens_hsa03010	2.51784405
10	N-Glycan biosynthesis_Homo sapiens_hsa00510	2.49398612
11	Oocyte meiosis_Homo sapiens_hsa04114	2.36845023
12	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.31420361
13	mRNA surveillance pathway_Homo sapiens_hsa03015	2.30655407
14	Nucleotide excision repair_Homo sapiens_hsa03420	2.20169819
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.13984804
16	Basal transcription factors_Homo sapiens_hsa03022	2.12780551
17	Base excision repair_Homo sapiens_hsa03410	1.96408669
18	Proteasome_Homo sapiens_hsa03050	1.86274346
19	Regulation of autophagy_Homo sapiens_hsa04140	1.80389241
20	Non-homologous end-joining_Homo sapiens_hsa03450	1.76168615
21	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.72146166
22	Gap junction_Homo sapiens_hsa04540	1.69861931
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.67714370
24	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.62946694
25	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.60780127
26	Parkinsons disease_Homo sapiens_hsa05012	1.60363572
27	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.55179625
28	Spliceosome_Homo sapiens_hsa03040	1.51986840
29	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.51792547
30	RNA polymerase_Homo sapiens_hsa03020	1.50979982
31	Pyruvate metabolism_Homo sapiens_hsa00620	1.49034601
32	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.45171733
33	Apoptosis_Homo sapiens_hsa04210	1.42888141
34	RNA degradation_Homo sapiens_hsa03018	1.34238443
35	Alcoholism_Homo sapiens_hsa05034	1.33376429
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30448030
37	Huntingtons disease_Homo sapiens_hsa05016	1.23047767
38	Phenylalanine metabolism_Homo sapiens_hsa00360	1.16167981
39	Arginine biosynthesis_Homo sapiens_hsa00220	1.15565774
40	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.14691859
41	One carbon pool by folate_Homo sapiens_hsa00670	1.14168329
42	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.07808824
43	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.05102215
44	Propanoate metabolism_Homo sapiens_hsa00640	1.02872322
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97608926
46	Purine metabolism_Homo sapiens_hsa00230	0.96022726
47	Folate biosynthesis_Homo sapiens_hsa00790	0.90482707
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.87522315
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.85718349
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.80385144
51	p53 signaling pathway_Homo sapiens_hsa04115	0.75157865
52	Acute myeloid leukemia_Homo sapiens_hsa05221	0.73510014
53	Viral carcinogenesis_Homo sapiens_hsa05203	0.72928397
54	Oxidative phosphorylation_Homo sapiens_hsa00190	0.69192382
55	Olfactory transduction_Homo sapiens_hsa04740	0.67148551
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.65358895
57	Phagosome_Homo sapiens_hsa04145	0.59971895
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.58724133
59	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57940496
60	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57845562
61	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.57388856
62	Glutathione metabolism_Homo sapiens_hsa00480	0.55756582
63	Metabolic pathways_Homo sapiens_hsa01100	0.54389545
64	Non-small cell lung cancer_Homo sapiens_hsa05223	0.51994918
65	Carbon metabolism_Homo sapiens_hsa01200	0.50661578
66	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49777581
67	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.47636145
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46124856
69	Steroid biosynthesis_Homo sapiens_hsa00100	0.43973876
70	Tyrosine metabolism_Homo sapiens_hsa00350	0.42751377
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.42523377
72	Retinol metabolism_Homo sapiens_hsa00830	0.41020297
73	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40775444
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40473105
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40265792
76	mTOR signaling pathway_Homo sapiens_hsa04150	0.37457759
77	Prostate cancer_Homo sapiens_hsa05215	0.37192932
78	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36222291
79	Endometrial cancer_Homo sapiens_hsa05213	0.35495282
80	Circadian rhythm_Homo sapiens_hsa04710	0.33012574
81	Prion diseases_Homo sapiens_hsa05020	0.32490215
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.31314553
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.30722108
84	Peroxisome_Homo sapiens_hsa04146	0.29201981
85	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.29107495
86	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.29101422
87	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.27988686
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.27177761
89	Nitrogen metabolism_Homo sapiens_hsa00910	0.27175299
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.26477534
91	FoxO signaling pathway_Homo sapiens_hsa04068	0.25842699
92	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.24904689
93	VEGF signaling pathway_Homo sapiens_hsa04370	0.24364700
94	Thyroid cancer_Homo sapiens_hsa05216	0.23628313
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.22667319
96	HTLV-I infection_Homo sapiens_hsa05166	0.21510331
97	Herpes simplex infection_Homo sapiens_hsa05168	0.20128728
98	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.19610099
99	Alzheimers disease_Homo sapiens_hsa05010	0.19279064
100	Small cell lung cancer_Homo sapiens_hsa05222	0.19081792

PAGE2B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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