PAGE4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in prostate and prostate cancer. It is also expressed in other male and female reproductive tissues including testis, fallopian tube, uterus, and placenta, as well as in testicular cancer and uterine cancer. The protein encoded by this gene shares sequence similarity with other GAGE/PAGE proteins, and also belongs to a family of CT (cancer-testis) antigens. The protein may play a role in benign and malignant prostate diseases. A related pseudogene is located on chromosome 7. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate gland growth (GO:0060736)9.55716737
2estrogen metabolic process (GO:0008210)9.47413980
3glucocorticoid biosynthetic process (GO:0006704)8.97997336
4regulation of gonadotropin secretion (GO:0032276)8.75689026
5androgen biosynthetic process (GO:0006702)8.73091143
6androgen metabolic process (GO:0008209)7.56722772
7multi-multicellular organism process (GO:0044706)7.30685623
8positive regulation of protein kinase C signaling (GO:0090037)7.09550579
9multi-organism reproductive process (GO:0044703)6.32297005
10vitamin transmembrane transport (GO:0035461)5.92809889
11positive regulation of growth hormone secretion (GO:0060124)5.77429811
12glucocorticoid metabolic process (GO:0008211)4.99177573
13hormone biosynthetic process (GO:0042446)4.95245217
14positive regulation of insulin receptor signaling pathway (GO:0046628)4.77196646
15desmosome organization (GO:0002934)4.67677116
16L-alpha-amino acid transmembrane transport (GO:1902475)4.55634938
17collecting duct development (GO:0072044)4.49113718
18response to gonadotropin (GO:0034698)4.44567960
19syncytium formation (GO:0006949)4.20771596
20bundle of His cell to Purkinje myocyte communication (GO:0086069)4.16373266
21regulation of transforming growth factor beta2 production (GO:0032909)4.07367729
22regulation of growth hormone secretion (GO:0060123)4.05442310
23JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)4.05176732
24auditory receptor cell stereocilium organization (GO:0060088)4.04975957
25paraxial mesoderm development (GO:0048339)3.87907304
26lung-associated mesenchyme development (GO:0060484)3.86199682
27endocrine hormone secretion (GO:0060986)3.82124568
28polarized epithelial cell differentiation (GO:0030859)3.79631884
29vitamin D metabolic process (GO:0042359)3.75790144
30iron ion import (GO:0097286)3.75459783
31branching involved in salivary gland morphogenesis (GO:0060445)3.67507045
32positive regulation of hormone biosynthetic process (GO:0046886)3.62220356
33regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.53235571
34bone morphogenesis (GO:0060349)3.42241990
35hippo signaling (GO:0035329)3.31265366
36notochord development (GO:0030903)3.27820401
37regulation of protein kinase C signaling (GO:0090036)3.24422379
38keratinocyte development (GO:0003334)3.23833083
39cranial suture morphogenesis (GO:0060363)3.23652267
40positive regulation of cellular response to insulin stimulus (GO:1900078)3.23542897
41positive regulation of hormone metabolic process (GO:0032352)3.18447547
42myoblast fusion (GO:0007520)3.11378896
43sphingoid metabolic process (GO:0046519)3.09664521
44positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.05074781
45regulation of G0 to G1 transition (GO:0070316)3.03727142
46estrogen biosynthetic process (GO:0006703)22.2966133
47COPI coating of Golgi vesicle (GO:0048205)2.99332555
48Golgi transport vesicle coating (GO:0048200)2.99332555
49regulation of odontogenesis (GO:0042481)2.98666231
50definitive hemopoiesis (GO:0060216)2.97238827
51cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.95018216
52response to vitamin A (GO:0033189)2.87799578
53negative regulation of smooth muscle cell differentiation (GO:0051151)2.84631483
54L-ascorbic acid metabolic process (GO:0019852)2.84432456
55fucose catabolic process (GO:0019317)2.82440581
56L-fucose metabolic process (GO:0042354)2.82440581
57L-fucose catabolic process (GO:0042355)2.82440581
58negative regulation of stem cell proliferation (GO:2000647)2.77340216
59lymph vessel development (GO:0001945)2.77111317
60nitric oxide biosynthetic process (GO:0006809)2.75836981
61cellular hormone metabolic process (GO:0034754)2.74773613
62regulation of sister chromatid cohesion (GO:0007063)2.69263162
63exocrine pancreas development (GO:0031017)2.66716878
64regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.62517067
65trophectodermal cell differentiation (GO:0001829)2.62111262
66syncytium formation by plasma membrane fusion (GO:0000768)2.60264678
67steroid biosynthetic process (GO:0006694)2.60222337
68protein neddylation (GO:0045116)2.58182495
69negative regulation of macrophage differentiation (GO:0045650)2.57945603
70hemoglobin metabolic process (GO:0020027)2.56414687
71heme transport (GO:0015886)2.54090217
72negative regulation of Notch signaling pathway (GO:0045746)2.50717471
73vascular endothelial growth factor signaling pathway (GO:0038084)2.45900596
74fucose metabolic process (GO:0006004)2.45883582
75negative regulation of activin receptor signaling pathway (GO:0032926)2.45615471
76myelin maintenance (GO:0043217)2.44064693
77regulation of glycogen (starch) synthase activity (GO:2000465)2.43390365
78outflow tract septum morphogenesis (GO:0003148)2.42692631
79diterpenoid biosynthetic process (GO:0016102)2.40428010
80erythrocyte maturation (GO:0043249)2.37695701
81adrenal gland development (GO:0030325)2.36948479
82nuclear pore complex assembly (GO:0051292)2.32742464
83valine metabolic process (GO:0006573)2.32673651
84interkinetic nuclear migration (GO:0022027)2.30236059
85bone trabecula formation (GO:0060346)2.30002729
86regulation of mesenchymal cell apoptotic process (GO:2001053)2.25992894
87regulation of RNA export from nucleus (GO:0046831)2.25588073
88pH reduction (GO:0045851)2.24486604
89post-embryonic morphogenesis (GO:0009886)2.23589758
90eyelid development in camera-type eye (GO:0061029)2.21290253
91melanin metabolic process (GO:0006582)2.20202145
92phenylpropanoid metabolic process (GO:0009698)2.19061153
93establishment of epithelial cell polarity (GO:0090162)2.18563682
94synapsis (GO:0007129)2.18515030
95mitotic cytokinesis (GO:0000281)2.17356976
96mitotic G2 DNA damage checkpoint (GO:0007095)2.16434708
97regulation of response to osmotic stress (GO:0047484)2.16264440
98pyrimidine-containing compound transmembrane transport (GO:0072531)2.15558454
99response to follicle-stimulating hormone (GO:0032354)11.2225056
100female pregnancy (GO:0007565)10.2978417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human8.41740611
2ZNF263_19887448_ChIP-Seq_K562_Human6.41948061
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human5.57597379
4EGR1_19032775_ChIP-ChIP_M12_Human4.42451160
5AR_21909140_ChIP-Seq_LNCAP_Human3.48320750
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.24805264
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.24805264
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.24805264
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.78391375
10E2F7_22180533_ChIP-Seq_HELA_Human2.50993132
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.43537303
12TRIM28_17542650_ChIP-ChIP_NTERA2_Human2.37159993
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24989933
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.18180084
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.16172299
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.12403373
17GATA3_24758297_ChIP-Seq_MCF-7_Human2.07833537
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98194869
19GATA1_19941826_ChIP-Seq_K562_Human1.89341902
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85384443
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.83601643
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83022990
23AHR_22903824_ChIP-Seq_MCF-7_Human1.78168006
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.75944307
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.74144148
26GATA4_25053715_ChIP-Seq_YYC3_Human1.66604420
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66301168
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.65995896
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63373166
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63026000
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.62347445
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49980095
33SCL_19346495_ChIP-Seq_HPC-7_Human1.49688437
34SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.49606128
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48398823
36PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46325888
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36905920
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35896022
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31292605
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.27456187
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.26966679
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24787088
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24078980
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.17488203
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16205279
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16050762
47GATA6_25053715_ChIP-Seq_YYC3_Human1.15379163
48NCOR1_26117541_ChIP-Seq_K562_Human1.14294731
49ELF5_23300383_ChIP-Seq_T47D_Human1.12766902
50POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12692370
51TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12275797
52ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11314701
53GATA2_19941826_ChIP-Seq_K562_Human1.09689408
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08096234
55RXR_22158963_ChIP-Seq_LIVER_Mouse1.07769318
56HTT_18923047_ChIP-ChIP_STHdh_Human1.07537010
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.05016520
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.03617139
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01837957
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01049971
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00937543
62* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00884931
63POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99379490
64CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98845897
65PPARA_22158963_ChIP-Seq_LIVER_Mouse0.98097785
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95645461
67ERG_20517297_ChIP-Seq_VCAP_Human0.94866297
68TRIM28_21343339_ChIP-Seq_HEK293_Human0.92807924
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.90835100
70ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.90345536
71RUNX1_27514584_Chip-Seq_MCF-7_Human0.89074820
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88480408
73DCP1A_22483619_ChIP-Seq_HELA_Human0.87454723
74SOX2_20726797_ChIP-Seq_SW620_Human0.87039282
75MYC_19030024_ChIP-ChIP_MESCs_Mouse0.86373935
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85368607
77PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85312588
78EST1_17652178_ChIP-ChIP_JURKAT_Human0.84777842
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83926915
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.83280281
81TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83156465
82HNF4A_19822575_ChIP-Seq_HepG2_Human0.82703288
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.82292140
84CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80837695
85TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.79505140
86E2F4_17652178_ChIP-ChIP_JURKAT_Human0.78442707
87GABP_17652178_ChIP-ChIP_JURKAT_Human0.78244175
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.77952280
89SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76408892
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.74486456
91LXR_22158963_ChIP-Seq_LIVER_Mouse0.74223971
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.72781998
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.72779530
94STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72428717
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70415864
96TBX3_20139965_ChIP-Seq_ESCs_Mouse0.70168024
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69523758
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69443617
99TBX3_20139965_ChIP-Seq_MESCs_Mouse0.68528948
100CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.68275043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation8.41100163
2MP0005377_hearing/vestibular/ear_phenot5.47530024
3MP0003878_abnormal_ear_physiology5.47530024
4MP0004264_abnormal_extraembryonic_tissu4.48536579
5MP0003941_abnormal_skin_development3.66556054
6MP0002163_abnormal_gland_morphology3.46962260
7MP0006276_abnormal_autonomic_nervous2.83672642
8MP0004019_abnormal_vitamin_homeostasis2.70015545
9MP0002098_abnormal_vibrissa_morphology2.64684433
10MP0005379_endocrine/exocrine_gland_phen2.64583657
11MP0001919_abnormal_reproductive_system2.57324802
12MP0000647_abnormal_sebaceous_gland2.55778502
13MP0005647_abnormal_sex_gland2.48457230
14MP0003567_abnormal_fetal_cardiomyocyte2.35880364
15MP0000372_irregular_coat_pigmentation2.24118469
16MP0000383_abnormal_hair_follicle2.18975483
17MP0010234_abnormal_vibrissa_follicle1.77765936
18MP0003959_abnormal_lean_body1.75712901
19MP0003385_abnormal_body_wall1.71944169
20MP0001666_abnormal_nutrient_absorption1.70746146
21MP0010678_abnormal_skin_adnexa1.68183441
22MP0003693_abnormal_embryo_hatching1.62302820
23MP0005076_abnormal_cell_differentiation1.60385094
24MP0003936_abnormal_reproductive_system1.60336548
25MP0009115_abnormal_fat_cell1.59413880
26MP0010307_abnormal_tumor_latency1.58329208
27MP0004957_abnormal_blastocyst_morpholog1.58257291
28MP0004782_abnormal_surfactant_physiolog1.55592275
29MP0005389_reproductive_system_phenotype1.51384271
30MP0009703_decreased_birth_body1.48327705
31MP0000613_abnormal_salivary_gland1.37594707
32MP0005408_hypopigmentation1.36915211
33MP0000377_abnormal_hair_follicle1.34172588
34MP0001440_abnormal_grooming_behavior1.25320975
35MP0002139_abnormal_hepatobiliary_system1.20449373
36MP0003890_abnormal_embryonic-extraembry1.19952670
37MP0000003_abnormal_adipose_tissue1.19589266
38MP0000639_abnormal_adrenal_gland1.18911070
39MP0003122_maternal_imprinting1.17756356
40MP0000566_synostosis1.10513823
41MP0004147_increased_porphyrin_level1.09605730
42MP0003718_maternal_effect1.08903859
43MP0002075_abnormal_coat/hair_pigmentati1.06924950
44MP0002086_abnormal_extraembryonic_tissu1.06379088
45MP0001293_anophthalmia1.04739470
46MP0004185_abnormal_adipocyte_glucose1.00095842
47MP0005636_abnormal_mineral_homeostasis0.99339008
48MP0003123_paternal_imprinting0.99123533
49MP0002876_abnormal_thyroid_physiology0.97861774
50MP0006138_congestive_heart_failure0.96787155
51MP0002653_abnormal_ependyma_morphology0.92745631
52MP0002938_white_spotting0.92587010
53MP0002210_abnormal_sex_determination0.91534738
54MP0003879_abnormal_hair_cell0.90552425
55MP0002138_abnormal_hepatobiliary_system0.89748545
56MP0005375_adipose_tissue_phenotype0.88868873
57MP0010368_abnormal_lymphatic_system0.87437811
58MP0010329_abnormal_lipoprotein_level0.87040279
59MP0001730_embryonic_growth_arrest0.86860504
60MP0003942_abnormal_urinary_system0.85911677
61MP0000367_abnormal_coat/_hair0.85208485
62MP0004947_skin_inflammation0.84221501
63MP0000427_abnormal_hair_cycle0.83978040
64MP0002796_impaired_skin_barrier0.81979207
65MP0002971_abnormal_brown_adipose0.80182824
66MP0005319_abnormal_enzyme/_coenzyme0.75760836
67MP0001186_pigmentation_phenotype0.75479708
68MP0003453_abnormal_keratinocyte_physiol0.73694664
69MP0005451_abnormal_body_composition0.73104976
70MP0010352_gastrointestinal_tract_polyps0.70915304
71MP0003136_yellow_coat_color0.70552239
72MP0002697_abnormal_eye_size0.69318136
73MP0000013_abnormal_adipose_tissue0.67997450
74MP0001929_abnormal_gametogenesis0.65623164
75MP0001340_abnormal_eyelid_morphology0.65494362
76MP0003699_abnormal_female_reproductive0.64375143
77MP0001145_abnormal_male_reproductive0.64193072
78MP0000653_abnormal_sex_gland0.64129992
79MP0002998_abnormal_bone_remodeling0.63752599
80MP0008775_abnormal_heart_ventricle0.62919738
81MP0001881_abnormal_mammary_gland0.62194014
82MP0005646_abnormal_pituitary_gland0.62088847
83MP0000627_abnormal_mammary_gland0.61738755
84MP0001756_abnormal_urination0.61173185
85MP0001697_abnormal_embryo_size0.59656970
86MP0005380_embryogenesis_phenotype0.59298357
87MP0001672_abnormal_embryogenesis/_devel0.59298357
88MP0005409_darkened_coat_color0.58878450
89MP0003868_abnormal_feces_composition0.58612152
90MP0001324_abnormal_eye_pigmentation0.57429662
91MP0002084_abnormal_developmental_patter0.56883114
92MP0009672_abnormal_birth_weight0.53670475
93MP0003935_abnormal_craniofacial_develop0.53613157
94MP0005330_cardiomyopathy0.52763563
95MP0002249_abnormal_larynx_morphology0.52640972
96MP0001216_abnormal_epidermal_layer0.52141945
97MP0001765_abnormal_ion_homeostasis0.51932990
98MP0005666_abnormal_adipose_tissue0.50960416
99MP0001764_abnormal_homeostasis0.50280973
100MP0005365_abnormal_bile_salt0.48868675

Predicted human phenotypes

RankGene SetZ-score
1Decreased number of large peripheral myelinated nerve fibers (HP:0003387)5.48274116
2Bilateral sensorineural hearing impairment (HP:0008619)5.04837828
3Capillary hemangiomas (HP:0005306)4.95758663
4Hypergonadotropic hypogonadism (HP:0000815)4.81261925
5Abnormal auditory evoked potentials (HP:0006958)4.71314205
6Bilateral microphthalmos (HP:0007633)4.71184447
7Bicornuate uterus (HP:0000813)4.69878408
8Upper limb muscle weakness (HP:0003484)4.58826839
9Right ventricular cardiomyopathy (HP:0011663)4.47890665
10Aplasia of the musculature (HP:0100854)4.33282332
11Proximal tubulopathy (HP:0000114)4.15950293
12Abnormal pupillary function (HP:0007686)4.00051989
13Myelomeningocele (HP:0002475)3.88989216
14Asymmetry of the thorax (HP:0001555)3.86523873
15Abnormality of dental color (HP:0011073)3.54300011
16Female pseudohermaphroditism (HP:0010458)3.45823315
17Abnormal lung lobation (HP:0002101)3.38505295
18Absent eyebrow (HP:0002223)3.34510050
19Cholecystitis (HP:0001082)3.33898849
20Abnormal gallbladder physiology (HP:0012438)3.33898849
21Muscle fibrillation (HP:0010546)3.21602230
22Choanal stenosis (HP:0000452)3.19457981
23Tongue fasciculations (HP:0001308)3.15465710
24Congenital ichthyosiform erythroderma (HP:0007431)3.06494651
25Accelerated skeletal maturation (HP:0005616)2.97111332
26Aplasia/Hypoplasia involving the musculature (HP:0001460)2.94771935
27Nonimmune hydrops fetalis (HP:0001790)2.93082558
28Paralysis (HP:0003470)2.90957340
29Abnormality of the aortic arch (HP:0012303)2.81686627
30Truncus arteriosus (HP:0001660)2.78774343
31Bifid tongue (HP:0010297)2.78550148
32Hypoplasia of the uterus (HP:0000013)2.77768825
33Severe Myopia (HP:0011003)2.67656875
34Facial cleft (HP:0002006)2.65803483
35Central scotoma (HP:0000603)2.60283085
36Renal tubular acidosis (HP:0001947)2.51892307
37Aplastic anemia (HP:0001915)2.49983973
38Chromsome breakage (HP:0040012)2.49332658
39Curly hair (HP:0002212)2.48812707
40Amelogenesis imperfecta (HP:0000705)2.48541570
41Abnormality of the lacrimal duct (HP:0011481)2.48022988
42Midline defect of the nose (HP:0004122)2.47290149
43Nephroblastoma (Wilms tumor) (HP:0002667)2.44817190
44Reticulocytosis (HP:0001923)2.43346129
45Clitoromegaly (HP:0000057)2.43259135
46Abnormal tarsal ossification (HP:0008369)2.41979427
47Absent eyelashes (HP:0000561)2.41663341
48Abnormality of the nasolacrimal system (HP:0000614)2.41373994
49Morphological abnormality of the middle ear (HP:0008609)2.39773177
50Woolly hair (HP:0002224)2.32300530
51Increased circulating renin level (HP:0000848)2.30628957
52Hypoplasia of the iris (HP:0007676)2.29992831
53Seborrheic dermatitis (HP:0001051)2.29545916
54Embryonal renal neoplasm (HP:0011794)2.25510315
55Aplasia cutis congenita (HP:0001057)2.24694730
56Ankyloglossia (HP:0010296)2.24076905
57Aplasia/Hypoplasia of the sternum (HP:0006714)2.23630342
58Pallor (HP:0000980)2.20074924
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16265598
60Palpitations (HP:0001962)2.13450464
61Anosmia (HP:0000458)2.12613425
62High anterior hairline (HP:0009890)2.12572941
63Basal cell carcinoma (HP:0002671)2.09302477
64Hyperphosphaturia (HP:0003109)2.07779031
65Partial agenesis of the corpus callosum (HP:0001338)2.07732466
66Metaphyseal cupping (HP:0003021)2.07495823
67Osteomalacia (HP:0002749)2.05595393
68Anophthalmia (HP:0000528)2.05084351
69Advanced eruption of teeth (HP:0006288)2.03982356
70Testicular neoplasm (HP:0010788)2.03400868
71Tetany (HP:0001281)2.02504839
72Back pain (HP:0003418)2.01851255
73Abnormality of reticulocytes (HP:0004312)1.99713863
74Abnormal urine phosphate concentration (HP:0012599)1.97548771
75Abnormal pancreas size (HP:0012094)1.97146595
76Cone-rod dystrophy (HP:0000548)1.96208878
77Abnormality of methionine metabolism (HP:0010901)1.90897489
78Pancreatic islet-cell hyperplasia (HP:0004510)1.90750153
79Abnormal foot bone ossification (HP:0010675)1.90537635
80Hypoparathyroidism (HP:0000829)1.90449840
81Intrahepatic cholestasis (HP:0001406)1.90105287
82Renal tubular dysfunction (HP:0000124)1.87392219
83Ectopic kidney (HP:0000086)1.86735650
84Hypomagnesemia (HP:0002917)1.85809682
85Polycythemia (HP:0001901)1.85684549
86Aplasia/hypoplasia of the uterus (HP:0008684)1.84541067
87Impulsivity (HP:0100710)1.83623008
88Asymmetric growth (HP:0100555)1.83098143
89Abnormality of the pupil (HP:0000615)1.79178141
90Abnormal hemoglobin (HP:0011902)1.76134519
91Duodenal stenosis (HP:0100867)1.73541476
92Small intestinal stenosis (HP:0012848)1.73541476
93Delayed epiphyseal ossification (HP:0002663)1.73378332
94Wide intermamillary distance (HP:0006610)1.72375664
95Acanthocytosis (HP:0001927)1.71676229
96Tracheal stenosis (HP:0002777)1.68865705
97Meningocele (HP:0002435)1.68439200
98Abnormal gallbladder morphology (HP:0012437)1.68294367
99Megaloblastic anemia (HP:0001889)1.65470156
100Abnormality of the pubic bones (HP:0003172)1.65357436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS18.04636657
2STK38L5.36525003
3NME15.21189205
4LATS24.86233696
5MST43.42946059
6KDR3.37490394
7AKT32.85263954
8DAPK22.74755358
9STK392.58470295
10WNK42.48888116
11PDGFRA2.32346850
12STK32.26874138
13STK382.11704457
14EPHA22.02442712
15OXSR11.97168117
16NME21.96559645
17EIF2AK11.71325683
18MAP3K71.69840584
19TTK1.48873672
20ICK1.48453085
21WEE11.43995075
22DAPK11.31805657
23PLK41.29323378
24EIF2AK31.15621672
25STK241.08712476
26BMPR20.95164940
27RPS6KA40.85115425
28PDGFRB0.84600135
29MYLK0.84278224
30DAPK30.83169685
31MET0.68735062
32PLK20.67918115
33FGFR20.61694514
34MST1R0.60079674
35AURKB0.58592627
36YES10.57540747
37LRRK20.56853301
38TRPM70.55747698
39BRSK20.51722027
40AKT20.50516845
41PBK0.50236706
42PLK30.47577467
43PKN10.47451195
44CLK10.46019459
45BCR0.45091191
46MAP2K10.44309514
47STK100.43837568
48SRPK10.42411341
49BRD40.42033481
50NEK10.41860959
51BMX0.41791959
52NEK90.40651469
53TSSK60.40482304
54NEK20.38247990
55PRKCI0.36698809
56PLK10.34959834
57EGFR0.33630904
58NUAK10.32755828
59FGFR10.30923248
60BLK0.30360622
61SRC0.30031314
62MTOR0.29931110
63SMG10.28807538
64MAP3K20.28781541
65INSR0.27980669
66CHEK10.27488135
67RPS6KB20.26786282
68PRKAA20.26667093
69FGR0.24982904
70CDK10.24849879
71NTRK30.24746409
72FER0.23779741
73SCYL20.23288223
74CCNB10.23008790
75CDK70.22795625
76RPS6KA20.22531222
77CSNK1A10.22137258
78CSNK1E0.20903053
79BRSK10.19756977
80SGK10.19526041
81RPS6KC10.18768831
82RPS6KL10.18768831
83PTK60.18626641
84MAPK10.18284261
85CSNK2A20.17586534
86MAP3K120.17401078
87ATR0.17223308
88MAP2K60.17096084
89PDK20.16964211
90CSNK1D0.16939339
91INSRR0.16025272
92CHEK20.15778318
93RPS6KA60.15584260
94ERBB30.15231288
95CSNK2A10.14897582
96CAMK2G0.13275059
97PRKCA0.13227107
98CDC42BPA0.13197994
99AURKA0.13150814
100PDPK10.13020630

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001406.13064445
2Ovarian steroidogenesis_Homo sapiens_hsa049135.59759199
3Folate biosynthesis_Homo sapiens_hsa007903.29346921
4Collecting duct acid secretion_Homo sapiens_hsa049662.30902445
5Jak-STAT signaling pathway_Homo sapiens_hsa046302.08436731
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97885068
7Vitamin digestion and absorption_Homo sapiens_hsa049771.92065244
8Mineral absorption_Homo sapiens_hsa049781.86620149
9N-Glycan biosynthesis_Homo sapiens_hsa005101.80931210
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.77149003
11Homologous recombination_Homo sapiens_hsa034401.77067275
12Renin-angiotensin system_Homo sapiens_hsa046141.47799375
13Mismatch repair_Homo sapiens_hsa034301.46558797
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.39976045
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36974258
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.35145187
17Arginine and proline metabolism_Homo sapiens_hsa003301.34175561
18Non-homologous end-joining_Homo sapiens_hsa034501.33700721
19Ribosome_Homo sapiens_hsa030101.31178838
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28289369
21Nucleotide excision repair_Homo sapiens_hsa034201.27589568
22Vitamin B6 metabolism_Homo sapiens_hsa007501.22948885
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22155615
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22078503
25Caffeine metabolism_Homo sapiens_hsa002321.20318080
26Fatty acid biosynthesis_Homo sapiens_hsa000611.17360329
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13977177
28Hedgehog signaling pathway_Homo sapiens_hsa043401.13606780
29Histidine metabolism_Homo sapiens_hsa003401.11937169
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.10913561
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10095745
32Pyruvate metabolism_Homo sapiens_hsa006201.09634023
33Arginine biosynthesis_Homo sapiens_hsa002201.09042894
34Vibrio cholerae infection_Homo sapiens_hsa051101.08373314
35Proteasome_Homo sapiens_hsa030501.04730470
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.03175508
37Sphingolipid metabolism_Homo sapiens_hsa006001.01133375
38Propanoate metabolism_Homo sapiens_hsa006401.00204812
39One carbon pool by folate_Homo sapiens_hsa006700.97669219
40RNA transport_Homo sapiens_hsa030130.96949994
41DNA replication_Homo sapiens_hsa030300.95999590
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95956399
43Hippo signaling pathway_Homo sapiens_hsa043900.95334998
44PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94678931
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.93517155
46Basal transcription factors_Homo sapiens_hsa030220.91950383
47Basal cell carcinoma_Homo sapiens_hsa052170.91885527
48Tryptophan metabolism_Homo sapiens_hsa003800.89815953
49Fructose and mannose metabolism_Homo sapiens_hsa000510.88439766
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86452997
51Fanconi anemia pathway_Homo sapiens_hsa034600.86220068
52Peroxisome_Homo sapiens_hsa041460.84669862
53Retinol metabolism_Homo sapiens_hsa008300.84649574
54Adherens junction_Homo sapiens_hsa045200.83385482
55Steroid biosynthesis_Homo sapiens_hsa001000.83224256
56Spliceosome_Homo sapiens_hsa030400.81453131
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79344560
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78910166
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77895230
60Metabolic pathways_Homo sapiens_hsa011000.76939557
61Protein export_Homo sapiens_hsa030600.72960994
62Carbon metabolism_Homo sapiens_hsa012000.71384903
63Biosynthesis of amino acids_Homo sapiens_hsa012300.70692284
64Tight junction_Homo sapiens_hsa045300.70299546
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69152970
66Fatty acid metabolism_Homo sapiens_hsa012120.68858717
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68518290
68Oxidative phosphorylation_Homo sapiens_hsa001900.68015209
69mRNA surveillance pathway_Homo sapiens_hsa030150.67916239
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66411142
71Renal cell carcinoma_Homo sapiens_hsa052110.65137877
72Inositol phosphate metabolism_Homo sapiens_hsa005620.64955435
73Cell cycle_Homo sapiens_hsa041100.64611578
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63251472
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62589500
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62153367
77RNA degradation_Homo sapiens_hsa030180.61632044
78Thyroid cancer_Homo sapiens_hsa052160.57399664
79Tyrosine metabolism_Homo sapiens_hsa003500.53709341
80Other glycan degradation_Homo sapiens_hsa005110.53379818
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52178683
82HIF-1 signaling pathway_Homo sapiens_hsa040660.51252879
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47060507
84Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46187358
85Ras signaling pathway_Homo sapiens_hsa040140.46090261
86Chemical carcinogenesis_Homo sapiens_hsa052040.45057822
87Bile secretion_Homo sapiens_hsa049760.44927765
88PPAR signaling pathway_Homo sapiens_hsa033200.43075950
89Bladder cancer_Homo sapiens_hsa052190.40103026
90Thyroid hormone synthesis_Homo sapiens_hsa049180.39967091
91Phenylalanine metabolism_Homo sapiens_hsa003600.39368468
92Pathways in cancer_Homo sapiens_hsa052000.38122508
93ECM-receptor interaction_Homo sapiens_hsa045120.37805680
94ABC transporters_Homo sapiens_hsa020100.37720876
95Fatty acid degradation_Homo sapiens_hsa000710.37577797
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.35104467
97Synaptic vesicle cycle_Homo sapiens_hsa047210.34427984
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33610077
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32072031
100Fatty acid elongation_Homo sapiens_hsa000620.32042562

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