PAICSP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)6.89029734
2presynaptic membrane assembly (GO:0097105)6.61649610
3neuronal action potential propagation (GO:0019227)5.49207289
4tongue development (GO:0043586)5.40734678
5presynaptic membrane organization (GO:0097090)5.21831407
6heme transport (GO:0015886)4.65790494
7neuron fate determination (GO:0048664)4.64393706
8neuronal stem cell maintenance (GO:0097150)4.37308737
9radial glial cell differentiation (GO:0060019)4.22064186
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.16023964
11protein localization to synapse (GO:0035418)4.14263256
12pyrimidine nucleobase catabolic process (GO:0006208)4.11667273
13gamma-aminobutyric acid transport (GO:0015812)3.77796314
14negative regulation of cytosolic calcium ion concentration (GO:0051481)3.70630187
15brain morphogenesis (GO:0048854)3.69625827
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.66214162
17nonmotile primary cilium assembly (GO:0035058)3.65615720
18positive regulation of developmental pigmentation (GO:0048087)3.64607253
19iron coordination entity transport (GO:1901678)3.64145052
20protein localization to cilium (GO:0061512)3.62167209
21neuron cell-cell adhesion (GO:0007158)3.60937262
22GMP metabolic process (GO:0046037)3.56296737
23negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.54783188
24regulation of timing of cell differentiation (GO:0048505)3.52575018
25startle response (GO:0001964)3.46953989
26regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.46104789
27positive regulation by host of viral transcription (GO:0043923)3.44742220
28rRNA catabolic process (GO:0016075)3.39940971
29cilium movement (GO:0003341)3.39601542
30epithelial cilium movement (GO:0003351)3.38630598
31intraciliary transport (GO:0042073)3.35340840
32limb bud formation (GO:0060174)3.34916789
33response to nitrosative stress (GO:0051409)3.26752576
34cilium organization (GO:0044782)3.26456154
35nucleobase catabolic process (GO:0046113)3.25937099
36potassium ion export (GO:0071435)3.25266099
37cilium morphogenesis (GO:0060271)3.23277851
38glycosphingolipid biosynthetic process (GO:0006688)3.21549609
39negative regulation of epidermal cell differentiation (GO:0045605)3.20106738
40regulation of cilium movement (GO:0003352)3.19480721
41cell morphogenesis involved in neuron differentiation (GO:0048667)3.19263469
42regulation of respiratory system process (GO:0044065)3.16193905
43cilium assembly (GO:0042384)3.15266972
44potassium ion import (GO:0010107)3.13716104
45cellular ketone body metabolic process (GO:0046950)3.13659189
46telencephalon development (GO:0021537)3.08573288
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08360102
48negative regulation of translation, ncRNA-mediated (GO:0040033)3.08360102
49regulation of translation, ncRNA-mediated (GO:0045974)3.08360102
50protein-cofactor linkage (GO:0018065)3.03049825
51appendage development (GO:0048736)2.97109358
52limb development (GO:0060173)2.97109358
53regulation of development, heterochronic (GO:0040034)2.94415685
54positive regulation of oligodendrocyte differentiation (GO:0048714)2.90361771
55otic vesicle formation (GO:0030916)2.89234441
56establishment of nucleus localization (GO:0040023)2.89006294
57astrocyte differentiation (GO:0048708)2.88397277
58neurotransmitter-gated ion channel clustering (GO:0072578)2.87039189
59RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86225621
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86187287
61forebrain neuron differentiation (GO:0021879)2.85484497
62resolution of meiotic recombination intermediates (GO:0000712)2.85163964
63positive regulation of catecholamine secretion (GO:0033605)2.85139895
64mechanosensory behavior (GO:0007638)2.85096317
65membrane repolarization (GO:0086009)2.84755706
66adult feeding behavior (GO:0008343)2.84515695
67cell proliferation in forebrain (GO:0021846)2.79736663
68histone H2A acetylation (GO:0043968)2.77705915
69photoreceptor cell maintenance (GO:0045494)2.77559869
70kynurenine metabolic process (GO:0070189)2.77259801
71negative regulation by host of viral transcription (GO:0043922)2.74838435
72central nervous system projection neuron axonogenesis (GO:0021952)2.74349024
73membrane repolarization during action potential (GO:0086011)2.73035125
74neuronal action potential (GO:0019228)2.69559317
75neurotransmitter uptake (GO:0001504)2.69542170
76ketone body metabolic process (GO:1902224)2.68790769
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.68046262
78dendrite morphogenesis (GO:0048813)2.67613725
79dosage compensation (GO:0007549)2.67455715
80axoneme assembly (GO:0035082)2.64446070
81ncRNA catabolic process (GO:0034661)2.62020685
82neuromuscular process controlling posture (GO:0050884)2.61182093
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60811248
84regulation of centriole replication (GO:0046599)2.60755050
85membrane depolarization during action potential (GO:0086010)2.60746468
86cerebral cortex cell migration (GO:0021795)2.59006309
87keratinocyte development (GO:0003334)2.58323871
88negative regulation of systemic arterial blood pressure (GO:0003085)2.57623411
89regulation of glycogen (starch) synthase activity (GO:2000465)2.56383998
90regulation of pigment cell differentiation (GO:0050932)2.55276933
91tryptophan catabolic process (GO:0006569)2.54487174
92indole-containing compound catabolic process (GO:0042436)2.54487174
93indolalkylamine catabolic process (GO:0046218)2.54487174
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.52073230
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.51821592
96cilium or flagellum-dependent cell motility (GO:0001539)2.51125227
97negative regulation of appetite (GO:0032099)2.49405757
98negative regulation of response to food (GO:0032096)2.49405757
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.48869538
100protein K6-linked ubiquitination (GO:0085020)2.47950388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.92171131
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.73807935
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.71140387
4VDR_22108803_ChIP-Seq_LS180_Human3.47762909
5ZNF274_21170338_ChIP-Seq_K562_Hela3.17376975
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.11147823
7EZH2_22144423_ChIP-Seq_EOC_Human3.05032363
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.84244662
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.80291277
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.77568183
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75882832
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73818059
13FUS_26573619_Chip-Seq_HEK293_Human2.49062184
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46084511
15IGF1R_20145208_ChIP-Seq_DFB_Human2.41430148
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.30721407
17EWS_26573619_Chip-Seq_HEK293_Human2.21331640
18P300_19829295_ChIP-Seq_ESCs_Human1.97048020
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92749529
20ELK1_19687146_ChIP-ChIP_HELA_Human1.91100329
21ER_23166858_ChIP-Seq_MCF-7_Human1.84225091
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84127163
23IRF1_19129219_ChIP-ChIP_H3396_Human1.82236866
24SMAD4_21799915_ChIP-Seq_A2780_Human1.77573849
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74608883
26TAF15_26573619_Chip-Seq_HEK293_Human1.72257509
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.71463467
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66584818
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.62730472
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.62676999
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.62121331
32MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61332998
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60545754
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57687415
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57341038
36STAT3_23295773_ChIP-Seq_U87_Human1.54618617
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52326097
38AR_25329375_ChIP-Seq_VCAP_Human1.49686825
39CBP_20019798_ChIP-Seq_JUKART_Human1.49154516
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49154516
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48812356
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.47249577
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.45192990
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45131501
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.43532373
46AR_21572438_ChIP-Seq_LNCaP_Human1.42300377
47TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39273339
48TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36408230
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36189688
50TCF4_23295773_ChIP-Seq_U87_Human1.35852070
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.34713725
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.34671216
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.34041991
54BCAT_22108803_ChIP-Seq_LS180_Human1.32195298
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31424347
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.31061305
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.30027776
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29132048
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26660408
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24086903
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23435954
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21916500
63POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21916500
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21840541
65REST_21632747_ChIP-Seq_MESCs_Mouse1.20235421
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20025594
67TP53_22573176_ChIP-Seq_HFKS_Human1.18882649
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.17876809
69VDR_23849224_ChIP-Seq_CD4+_Human1.15425342
70TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14750280
71P53_22387025_ChIP-Seq_ESCs_Mouse1.14642742
72SOX2_19829295_ChIP-Seq_ESCs_Human1.14554808
73NANOG_19829295_ChIP-Seq_ESCs_Human1.14554808
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11948602
75RUNX2_22187159_ChIP-Seq_PCA_Human1.11452096
76TP53_16413492_ChIP-PET_HCT116_Human1.11082553
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10471828
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10107263
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09636340
80JUN_21703547_ChIP-Seq_K562_Human1.08907382
81TCF4_22108803_ChIP-Seq_LS180_Human1.08396811
82CDX2_22108803_ChIP-Seq_LS180_Human1.08188831
83RNF2_27304074_Chip-Seq_NSC_Mouse1.07823034
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07785293
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06870777
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.06479271
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05850163
88SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.05653122
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.04926248
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03750123
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03110852
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03110852
93RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02232796
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.01495614
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.01014643
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00466264
97TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00248804
98P300_18555785_Chip-Seq_ESCs_Mouse1.00223343
99TP63_19390658_ChIP-ChIP_HaCaT_Human0.98892631
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98472574

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.88180904
2MP0003880_abnormal_central_pattern3.44934151
3MP0000569_abnormal_digit_pigmentation3.38663967
4MP0005084_abnormal_gallbladder_morpholo3.15251627
5MP0002638_abnormal_pupillary_reflex2.76446933
6MP0001529_abnormal_vocalization2.58086822
7MP0001984_abnormal_olfaction2.50500150
8MP0008789_abnormal_olfactory_epithelium2.48528957
9MP0009046_muscle_twitch2.39160611
10MP0004142_abnormal_muscle_tone2.37372974
11MP0002928_abnormal_bile_duct2.35541093
12MP0000778_abnormal_nervous_system2.33296577
13MP0003045_fibrosis2.24652980
14MP0008004_abnormal_stomach_pH2.17981303
15MP0005394_taste/olfaction_phenotype2.17468675
16MP0005499_abnormal_olfactory_system2.17468675
17MP0002102_abnormal_ear_morphology1.93137650
18MP0005551_abnormal_eye_electrophysiolog1.88533154
19MP0006072_abnormal_retinal_apoptosis1.85394039
20MP0001968_abnormal_touch/_nociception1.80410000
21MP0008877_abnormal_DNA_methylation1.80130040
22MP0000427_abnormal_hair_cycle1.78328991
23MP0003787_abnormal_imprinting1.72274221
24MP0002736_abnormal_nociception_after1.70176276
25MP0002837_dystrophic_cardiac_calcinosis1.69571655
26MP0006292_abnormal_olfactory_placode1.66364042
27MP0009745_abnormal_behavioral_response1.65125042
28MP0009379_abnormal_foot_pigmentation1.63990412
29MP0004270_analgesia1.52869085
30MP0005253_abnormal_eye_physiology1.51816662
31MP0005248_abnormal_Harderian_gland1.51116178
32MP0009053_abnormal_anal_canal1.49141632
33MP0010368_abnormal_lymphatic_system1.41284861
34MP0000955_abnormal_spinal_cord1.39815069
35MP0003121_genomic_imprinting1.37626128
36MP0006276_abnormal_autonomic_nervous1.36201030
37MP0001501_abnormal_sleep_pattern1.34607267
38MP0003011_delayed_dark_adaptation1.33770374
39MP0001986_abnormal_taste_sensitivity1.33611882
40MP0008775_abnormal_heart_ventricle1.33609028
41MP0001286_abnormal_eye_development1.33175248
42MP0002557_abnormal_social/conspecific_i1.30428082
43MP0002067_abnormal_sensory_capabilities1.29173600
44MP0005386_behavior/neurological_phenoty1.29087714
45MP0004924_abnormal_behavior1.29087714
46MP0002751_abnormal_autonomic_nervous1.28957159
47MP0002734_abnormal_mechanical_nocicepti1.27163131
48MP0002272_abnormal_nervous_system1.26671041
49MP0003136_yellow_coat_color1.24742324
50MP0005195_abnormal_posterior_eye1.23571894
51MP0002064_seizures1.23399688
52MP0008995_early_reproductive_senescence1.23127756
53MP0008058_abnormal_DNA_repair1.22371729
54MP0006035_abnormal_mitochondrial_morpho1.21441964
55MP0002572_abnormal_emotion/affect_behav1.21011587
56MP0003635_abnormal_synaptic_transmissio1.20062492
57MP0000631_abnormal_neuroendocrine_gland1.18825893
58MP0001970_abnormal_pain_threshold1.18406213
59MP0003890_abnormal_embryonic-extraembry1.17261611
60MP0003755_abnormal_palate_morphology1.15006137
61MP0004043_abnormal_pH_regulation1.12853273
62MP0002733_abnormal_thermal_nociception1.12448239
63MP0002152_abnormal_brain_morphology1.11148989
64MP0009250_abnormal_appendicular_skeleto1.09274359
65MP0005367_renal/urinary_system_phenotyp1.09091713
66MP0000516_abnormal_urinary_system1.09091713
67MP0005423_abnormal_somatic_nervous1.06810882
68MP0001486_abnormal_startle_reflex1.05784264
69MP0003122_maternal_imprinting1.05394525
70MP0002063_abnormal_learning/memory/cond1.04685287
71MP0002882_abnormal_neuron_morphology1.03898535
72MP0002752_abnormal_somatic_nervous1.03598774
73MP0002095_abnormal_skin_pigmentation1.02397386
74MP0003861_abnormal_nervous_system1.00902654
75MP0000613_abnormal_salivary_gland0.96477354
76MP0002163_abnormal_gland_morphology0.89633793
77MP0002234_abnormal_pharynx_morphology0.89418404
78MP0004215_abnormal_myocardial_fiber0.88923061
79MP0003646_muscle_fatigue0.88828225
80MP0003119_abnormal_digestive_system0.87633551
81MP0004811_abnormal_neuron_physiology0.87165289
82MP0001664_abnormal_digestion0.83144069
83MP0000013_abnormal_adipose_tissue0.82786595
84MP0002069_abnormal_eating/drinking_beha0.82209109
85MP0000647_abnormal_sebaceous_gland0.82186798
86MP0002277_abnormal_respiratory_mucosa0.80970282
87MP0000026_abnormal_inner_ear0.80636024
88MP0005391_vision/eye_phenotype0.79950133
89MP0008961_abnormal_basal_metabolism0.79860286
90MP0001188_hyperpigmentation0.77467441
91MP0005645_abnormal_hypothalamus_physiol0.77251307
92MP0003937_abnormal_limbs/digits/tail_de0.76978527
93MP0004133_heterotaxia0.76072922
94MP0002184_abnormal_innervation0.75807462
95MP0005083_abnormal_biliary_tract0.75589858
96MP0002938_white_spotting0.75495553
97MP0004084_abnormal_cardiac_muscle0.71668474
98MP0010770_preweaning_lethality0.70125477
99MP0002082_postnatal_lethality0.70125477
100MP0004885_abnormal_endolymph0.68668067

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)6.02798343
2Pancreatic fibrosis (HP:0100732)4.43675266
3Atonic seizures (HP:0010819)4.03103004
4Medial flaring of the eyebrow (HP:0010747)3.91702481
5Thyroid-stimulating hormone excess (HP:0002925)3.85228791
6Focal motor seizures (HP:0011153)3.75351826
7Abnormal hair whorl (HP:0010721)3.69620479
8Intestinal atresia (HP:0011100)3.69263944
9Pancreatic cysts (HP:0001737)3.61579954
10True hermaphroditism (HP:0010459)3.51295091
11Hemiparesis (HP:0001269)3.47239690
12Dialeptic seizures (HP:0011146)3.34704824
13Gait imbalance (HP:0002141)3.06522160
14Absence seizures (HP:0002121)3.02015207
15Abnormal ciliary motility (HP:0012262)3.01032205
16Congenital primary aphakia (HP:0007707)3.00124274
17Abnormal biliary tract physiology (HP:0012439)2.98676650
18Bile duct proliferation (HP:0001408)2.98676650
19Progressive cerebellar ataxia (HP:0002073)2.97160372
20Large for gestational age (HP:0001520)2.95255665
21Abnormality of midbrain morphology (HP:0002418)2.95071898
22Molar tooth sign on MRI (HP:0002419)2.95071898
23Volvulus (HP:0002580)2.92427072
24Nephrogenic diabetes insipidus (HP:0009806)2.85903935
25Focal seizures (HP:0007359)2.84787195
26Lissencephaly (HP:0001339)2.79770301
27Hyperventilation (HP:0002883)2.79728718
28Absent speech (HP:0001344)2.79177283
29Poor coordination (HP:0002370)2.67510779
30Nephronophthisis (HP:0000090)2.61460112
31Rectovaginal fistula (HP:0000143)2.61195037
32Rectal fistula (HP:0100590)2.61195037
33Postaxial foot polydactyly (HP:0001830)2.60551243
34Optic nerve hypoplasia (HP:0000609)2.56292042
35Gastrointestinal atresia (HP:0002589)2.55038497
36Abnormality of the renal medulla (HP:0100957)2.52516654
37Acute necrotizing encephalopathy (HP:0006965)2.48886268
38Abnormal respiratory motile cilium physiology (HP:0012261)2.48048699
39Rhinitis (HP:0012384)2.47622273
40Dysdiadochokinesis (HP:0002075)2.43884564
41Hypochromic anemia (HP:0001931)2.36891954
42Febrile seizures (HP:0002373)2.35844556
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.32066989
44Abnormality of the ileum (HP:0001549)2.31079475
45Sclerocornea (HP:0000647)2.27169603
46Abnormal respiratory motile cilium morphology (HP:0005938)2.26715002
47Abnormal respiratory epithelium morphology (HP:0012253)2.26715002
48Aplasia/Hypoplasia of the lens (HP:0008063)2.25928834
49Tubulointerstitial nephritis (HP:0001970)2.25826601
50Attenuation of retinal blood vessels (HP:0007843)2.25602892
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.25000105
52Tubular atrophy (HP:0000092)2.21021187
533-Methylglutaconic aciduria (HP:0003535)2.20720415
54Cystic liver disease (HP:0006706)2.20102491
55Acute encephalopathy (HP:0006846)2.19967868
56Bony spicule pigmentary retinopathy (HP:0007737)2.19562332
57Abnormality of the labia minora (HP:0012880)2.19504459
58Progressive macrocephaly (HP:0004481)2.19392741
59Abnormality of the renal cortex (HP:0011035)2.18963827
60Intestinal fistula (HP:0100819)2.14033518
61Postaxial hand polydactyly (HP:0001162)2.13358830
62Optic disc pallor (HP:0000543)2.12475173
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.10533124
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.10196069
65Polyphagia (HP:0002591)2.07903835
66Patellar aplasia (HP:0006443)2.07514954
67Drooling (HP:0002307)2.06081907
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.05676967
69Abnormality of the pons (HP:0007361)2.02739410
70Genital tract atresia (HP:0001827)2.01976934
71Pendular nystagmus (HP:0012043)2.01768731
72Meckel diverticulum (HP:0002245)1.99640842
73Vaginal atresia (HP:0000148)1.99573468
74Aplasia/Hypoplasia of the patella (HP:0006498)1.99061898
75Vaginal fistula (HP:0004320)1.98258274
76Papillary thyroid carcinoma (HP:0002895)1.97148293
77Congenital hepatic fibrosis (HP:0002612)1.97031602
78Abnormal mitochondria in muscle tissue (HP:0008316)1.96965452
79Clonus (HP:0002169)1.95965855
80Hypoplasia of the pons (HP:0012110)1.95002536
81Heterotopia (HP:0002282)1.93237050
82Congenital stationary night blindness (HP:0007642)1.93189429
83Triphalangeal thumb (HP:0001199)1.89960754
84Oculomotor apraxia (HP:0000657)1.87116041
85Prominent nasal bridge (HP:0000426)1.86657899
86Anencephaly (HP:0002323)1.86212146
87Excessive salivation (HP:0003781)1.85885927
88Cerebellar dysplasia (HP:0007033)1.84864507
89Tubulointerstitial abnormality (HP:0001969)1.84786073
90Retinal dysplasia (HP:0007973)1.84782765
91Prolonged QT interval (HP:0001657)1.83901763
92Narrow nasal bridge (HP:0000446)1.82961221
93Esophageal atresia (HP:0002032)1.82954184
94Narrow forehead (HP:0000341)1.81232959
95Hemiplegia (HP:0002301)1.80674679
96Broad foot (HP:0001769)1.79919616
97Short foot (HP:0001773)1.79787490
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.78036531
99Absent/shortened dynein arms (HP:0200106)1.78036531
100Abnormal rod and cone electroretinograms (HP:0008323)1.77239406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.18127347
2CASK5.06757275
3FRK4.19018697
4PNCK3.83566298
5MARK13.16186720
6WNK33.14742380
7MAP2K72.64571339
8AKT32.57571178
9ERBB42.26941320
10NUAK12.18274038
11MAP3K42.17808091
12VRK12.16408884
13EPHB22.08410710
14CDK191.92013934
15MAP4K21.84378806
16ADRBK21.70569345
17BMPR1B1.69768741
18EIF2AK11.58698918
19CDK31.57685717
20TSSK61.56593632
21BRD41.46973985
22PIM21.46795613
23MAPK131.42223238
24WEE11.30741748
25CSNK1G21.30234897
26MKNK21.23480500
27DYRK21.12891512
28SGK21.11001228
29MAP2K41.08924083
30BCR1.05148395
31EIF2AK30.98314634
32CLK10.96703717
33PBK0.95437757
34SGK2230.92895518
35SGK4940.92895518
36IRAK10.92145451
37EPHA40.88736862
38PLK20.86657782
39PINK10.84645008
40PIK3CA0.84400539
41TRIM280.81307203
42WNK40.81077509
43PLK30.75879964
44MKNK10.75685710
45PRKCG0.74665445
46CAMKK20.69784881
47KSR10.69479193
48CDK80.68916435
49PHKG20.68711030
50PHKG10.68711030
51CSNK1G10.65485246
52PIK3CG0.64225293
53OXSR10.63811211
54CAMK2A0.63552087
55CSNK1G30.63376501
56GRK10.63279170
57DYRK1B0.63149744
58CSNK1A1L0.62901013
59SGK30.62725299
60ERBB30.62514100
61PLK40.59884005
62PRKCE0.59173511
63PRKD30.57877766
64DYRK1A0.53763896
65MAP3K90.53640385
66ERBB20.51788337
67RPS6KA50.48907623
68CAMK1G0.47041378
69NTRK30.43740676
70SRPK10.43328620
71OBSCN0.43303610
72EPHA30.43226714
73PKN10.41455691
74INSRR0.40464359
75SIK30.39687172
76ADRBK10.38601060
77PTK2B0.37926413
78RAF10.36565567
79CSNK1D0.35069125
80TAOK10.34913510
81PRKD10.34098715
82MAP3K60.33711289
83CAMK2G0.33443337
84SGK10.33408830
85STK390.32594693
86SIK20.31391164
87CDK50.31248986
88TAOK30.30579040
89TYRO30.29949937
90ACVR1B0.29794926
91ABL10.28349490
92CAMK10.28314527
93PRKACB0.27168481
94PAK30.26222732
95BRAF0.26199927
96ATM0.26020351
97CSNK1A10.25116457
98CSNK1E0.24782545
99PRKACA0.24428050
100MAPK100.24032750

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.74805552
2Basal transcription factors_Homo sapiens_hsa030223.46824834
3Protein export_Homo sapiens_hsa030603.38596189
4Fanconi anemia pathway_Homo sapiens_hsa034603.18007884
5RNA polymerase_Homo sapiens_hsa030202.78153752
6Nicotine addiction_Homo sapiens_hsa050332.65659610
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.43850602
8Butanoate metabolism_Homo sapiens_hsa006502.31363125
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22675660
10Phototransduction_Homo sapiens_hsa047442.12719756
11Oxidative phosphorylation_Homo sapiens_hsa001902.10782034
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.96041206
13Collecting duct acid secretion_Homo sapiens_hsa049661.90157216
14RNA degradation_Homo sapiens_hsa030181.88276973
15ABC transporters_Homo sapiens_hsa020101.79859056
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.79057897
17Peroxisome_Homo sapiens_hsa041461.78747279
18Glycerolipid metabolism_Homo sapiens_hsa005611.68550101
19GABAergic synapse_Homo sapiens_hsa047271.68206967
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.63861781
21Parkinsons disease_Homo sapiens_hsa050121.59597067
22Huntingtons disease_Homo sapiens_hsa050161.54441067
23Ribosome_Homo sapiens_hsa030101.40641736
24Selenocompound metabolism_Homo sapiens_hsa004501.35672588
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34378044
26Cocaine addiction_Homo sapiens_hsa050301.30256613
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27741020
28Propanoate metabolism_Homo sapiens_hsa006401.26796202
29Steroid biosynthesis_Homo sapiens_hsa001001.26067346
30Amphetamine addiction_Homo sapiens_hsa050311.22224609
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.21743898
32Dopaminergic synapse_Homo sapiens_hsa047281.21472589
33Circadian entrainment_Homo sapiens_hsa047131.14949528
34Homologous recombination_Homo sapiens_hsa034401.13116502
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10291807
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.09350742
37Tryptophan metabolism_Homo sapiens_hsa003801.07415469
38Taste transduction_Homo sapiens_hsa047421.06602810
39Glutamatergic synapse_Homo sapiens_hsa047241.03068849
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02394952
41Alzheimers disease_Homo sapiens_hsa050101.01025629
42Morphine addiction_Homo sapiens_hsa050320.97810001
43Regulation of autophagy_Homo sapiens_hsa041400.97798884
44Circadian rhythm_Homo sapiens_hsa047100.97499768
45Retinol metabolism_Homo sapiens_hsa008300.95755308
46Cardiac muscle contraction_Homo sapiens_hsa042600.94391708
47Non-homologous end-joining_Homo sapiens_hsa034500.93742571
48Melanoma_Homo sapiens_hsa052180.91721828
49NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90287811
50Gastric acid secretion_Homo sapiens_hsa049710.89877521
51Nucleotide excision repair_Homo sapiens_hsa034200.89767761
52Colorectal cancer_Homo sapiens_hsa052100.89150182
53Axon guidance_Homo sapiens_hsa043600.89129571
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.87368576
55Choline metabolism in cancer_Homo sapiens_hsa052310.85883673
56cAMP signaling pathway_Homo sapiens_hsa040240.82600715
57Long-term depression_Homo sapiens_hsa047300.79992458
58Dorso-ventral axis formation_Homo sapiens_hsa043200.78139780
59Fatty acid degradation_Homo sapiens_hsa000710.77901857
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77567886
61Insulin secretion_Homo sapiens_hsa049110.77141363
62Ether lipid metabolism_Homo sapiens_hsa005650.74280962
63Synaptic vesicle cycle_Homo sapiens_hsa047210.65591693
64Endometrial cancer_Homo sapiens_hsa052130.64159363
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64055983
66Calcium signaling pathway_Homo sapiens_hsa040200.59466047
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58789914
68Lysine degradation_Homo sapiens_hsa003100.58052328
69Olfactory transduction_Homo sapiens_hsa047400.57565526
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54096399
71FoxO signaling pathway_Homo sapiens_hsa040680.53630848
72Cholinergic synapse_Homo sapiens_hsa047250.52896435
73Renal cell carcinoma_Homo sapiens_hsa052110.50011855
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49679459
75Fatty acid metabolism_Homo sapiens_hsa012120.49476450
76Oxytocin signaling pathway_Homo sapiens_hsa049210.49324702
77Serotonergic synapse_Homo sapiens_hsa047260.49150331
78PPAR signaling pathway_Homo sapiens_hsa033200.45103515
79Ovarian steroidogenesis_Homo sapiens_hsa049130.44944891
80Estrogen signaling pathway_Homo sapiens_hsa049150.44424379
81Salivary secretion_Homo sapiens_hsa049700.43585260
82Linoleic acid metabolism_Homo sapiens_hsa005910.42816181
83ErbB signaling pathway_Homo sapiens_hsa040120.42488721
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41676125
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40485709
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38062761
87Purine metabolism_Homo sapiens_hsa002300.36389089
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36295660
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34837121
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34185498
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33050185
92Type II diabetes mellitus_Homo sapiens_hsa049300.32079440
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.31282524
94Oocyte meiosis_Homo sapiens_hsa041140.30468826
95Metabolic pathways_Homo sapiens_hsa011000.29969231
96Fatty acid biosynthesis_Homo sapiens_hsa000610.28544497
97Folate biosynthesis_Homo sapiens_hsa007900.28267817
98Pancreatic secretion_Homo sapiens_hsa049720.28255116
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27093088
100Notch signaling pathway_Homo sapiens_hsa043300.26954607

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