PAICSP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of calcium ion-dependent exocytosis (GO:0045955)9.83907197
2negative regulation of cytosolic calcium ion concentration (GO:0051481)8.25218034
3regulation of acrosome reaction (GO:0060046)7.81872691
4gamma-aminobutyric acid transport (GO:0015812)7.08311296
5behavioral response to ethanol (GO:0048149)6.68283204
6opioid receptor signaling pathway (GO:0038003)6.66732156
7response to pheromone (GO:0019236)6.63224263
8regulation of protein polyubiquitination (GO:1902914)6.42162974
9regulation of translational termination (GO:0006449)6.12749416
10adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.03815781
11negative regulation of cAMP-mediated signaling (GO:0043951)5.52080436
12piRNA metabolic process (GO:0034587)5.13501871
13ether lipid metabolic process (GO:0046485)4.87138103
14positive regulation of cAMP-mediated signaling (GO:0043950)4.75111397
15adult feeding behavior (GO:0008343)4.58250013
16thrombin receptor signaling pathway (GO:0070493)4.38213838
17single strand break repair (GO:0000012)4.32365883
18copper ion homeostasis (GO:0055070)4.08909751
19regulation of protein glycosylation (GO:0060049)3.97651838
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87338542
21DNA replication-dependent nucleosome assembly (GO:0006335)3.79862130
22DNA replication-dependent nucleosome organization (GO:0034723)3.79862130
23ncRNA catabolic process (GO:0034661)3.70079471
24cornea development in camera-type eye (GO:0061303)3.68812921
25regulation of female receptivity (GO:0045924)3.68603499
26DNA deamination (GO:0045006)3.68326645
27negative regulation of cell aging (GO:0090344)3.61825707
28cell wall macromolecule catabolic process (GO:0016998)3.54746470
29negative regulation of nitric oxide biosynthetic process (GO:0045019)3.50362843
30regulation of rhodopsin mediated signaling pathway (GO:0022400)3.45763019
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44758218
32GMP metabolic process (GO:0046037)3.40438096
33sphingoid metabolic process (GO:0046519)3.35717715
34regulation of meiosis I (GO:0060631)3.29913608
35sphingosine metabolic process (GO:0006670)3.28671088
36sodium-independent organic anion transport (GO:0043252)3.27440327
37negative regulation of exocytosis (GO:0045920)3.23460453
38cAMP catabolic process (GO:0006198)3.20680565
39female mating behavior (GO:0060180)3.18444370
40transmission of nerve impulse (GO:0019226)3.17209648
41preassembly of GPI anchor in ER membrane (GO:0016254)3.16291673
42cellular hyperosmotic response (GO:0071474)3.15695082
43rhodopsin mediated signaling pathway (GO:0016056)3.10441176
44pyrimidine nucleobase catabolic process (GO:0006208)3.10344731
45regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.09509404
46response to misfolded protein (GO:0051788)3.06838696
47behavioral response to nicotine (GO:0035095)3.04203121
48regulation of glutamate receptor signaling pathway (GO:1900449)3.03709357
49membrane depolarization during action potential (GO:0086010)2.98568767
50indolalkylamine metabolic process (GO:0006586)2.98305422
51kynurenine metabolic process (GO:0070189)2.94304684
52signal peptide processing (GO:0006465)2.92751757
53cell wall macromolecule metabolic process (GO:0044036)2.89586025
54positive regulation of amino acid transport (GO:0051957)2.89578272
55detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.89274686
56replication fork processing (GO:0031297)2.86760709
57regulation of calcium ion-dependent exocytosis (GO:0017158)2.83874606
58neuronal action potential (GO:0019228)2.82339977
59diol metabolic process (GO:0034311)2.82074031
60multicellular organism reproduction (GO:0032504)2.81628212
61tryptophan catabolic process (GO:0006569)2.80902190
62indole-containing compound catabolic process (GO:0042436)2.80902190
63indolalkylamine catabolic process (GO:0046218)2.80902190
64positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.79434555
65cellular ketone body metabolic process (GO:0046950)2.78777602
66regulation of nuclear cell cycle DNA replication (GO:0033262)2.78002355
67negative regulation of DNA-dependent DNA replication (GO:2000104)2.77604907
68sister chromatid cohesion (GO:0007062)2.77136756
69cyclic nucleotide catabolic process (GO:0009214)2.73581653
70regulation of memory T cell differentiation (GO:0043380)2.71231812
71positive regulation of cardiac muscle cell differentiation (GO:2000727)2.70582163
72microtubule severing (GO:0051013)2.67919121
73pyrimidine dimer repair (GO:0006290)2.67702402
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66965842
75glyoxylate metabolic process (GO:0046487)2.66426554
76detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65704067
77snRNA metabolic process (GO:0016073)2.65701896
78ketone body metabolic process (GO:1902224)2.64771825
79regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.63037137
80nucleobase biosynthetic process (GO:0046112)2.62712424
81positive regulation of T-helper 1 type immune response (GO:0002827)2.62441183
82response to methylmercury (GO:0051597)2.61246120
83purine nucleobase biosynthetic process (GO:0009113)2.59521483
84rRNA modification (GO:0000154)2.58049088
85regulation of androgen receptor signaling pathway (GO:0060765)2.57430072
86regulation of cellular senescence (GO:2000772)2.55413037
87phosphorelay signal transduction system (GO:0000160)2.54522913
88regulation of cAMP-mediated signaling (GO:0043949)2.54199585
89rRNA methylation (GO:0031167)2.53666944
90peptidyl-histidine modification (GO:0018202)2.53484821
91nephron tubule formation (GO:0072079)2.53406453
92glycerol ether metabolic process (GO:0006662)2.53286703
93synaptic transmission, glutamatergic (GO:0035249)2.53240893
94nucleobase catabolic process (GO:0046113)2.51585318
95regulation of DNA endoreduplication (GO:0032875)2.50186447
96glomerular visceral epithelial cell development (GO:0072015)2.49786523
97snRNA processing (GO:0016180)2.47702671
98resolution of meiotic recombination intermediates (GO:0000712)2.47530258
99polyol catabolic process (GO:0046174)2.46390598
100response to caffeine (GO:0031000)2.45929352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.13643831
2ZNF274_21170338_ChIP-Seq_K562_Hela4.09965514
3GBX2_23144817_ChIP-Seq_PC3_Human2.82930635
4CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.67981181
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.50367636
6TAF15_26573619_Chip-Seq_HEK293_Human2.46964642
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.46385369
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.43426389
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.19476247
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10425422
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06799974
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04053019
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03976966
14EWS_26573619_Chip-Seq_HEK293_Human2.00876828
15PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99702751
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97416460
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93211370
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92765825
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90536293
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.82149189
21P300_19829295_ChIP-Seq_ESCs_Human1.82084094
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81076340
23SOX2_19829295_ChIP-Seq_ESCs_Human1.79809424
24NANOG_19829295_ChIP-Seq_ESCs_Human1.79809424
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.79783753
26EZH2_22144423_ChIP-Seq_EOC_Human1.76739595
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76335839
28CBP_20019798_ChIP-Seq_JUKART_Human1.75270665
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.75270665
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74498273
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.71588606
32IGF1R_20145208_ChIP-Seq_DFB_Human1.71290153
33POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61932305
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61932305
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61220098
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57773906
37FUS_26573619_Chip-Seq_HEK293_Human1.56130847
38STAT3_23295773_ChIP-Seq_U87_Human1.55445508
39AR_21572438_ChIP-Seq_LNCaP_Human1.54389478
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52561596
41EGR1_19032775_ChIP-ChIP_M12_Human1.51023323
42TP53_22573176_ChIP-Seq_HFKS_Human1.49421884
43SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47860120
44TCF4_23295773_ChIP-Seq_U87_Human1.45664937
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.45121615
46ER_23166858_ChIP-Seq_MCF-7_Human1.45012062
47BCAT_22108803_ChIP-Seq_LS180_Human1.42474223
48HTT_18923047_ChIP-ChIP_STHdh_Human1.41420418
49AR_25329375_ChIP-Seq_VCAP_Human1.39965727
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39086792
51CDX2_22108803_ChIP-Seq_LS180_Human1.34923102
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.32861434
53DROSHA_22980978_ChIP-Seq_HELA_Human1.31688536
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.30926801
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.28843674
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28043370
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28010723
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.26680285
59SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.24649575
60ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24533982
61NANOG_20526341_ChIP-Seq_ESCs_Human1.23573698
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.22639794
63SMAD4_21799915_ChIP-Seq_A2780_Human1.22430871
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21286915
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21064252
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.21042233
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.18225411
68RUNX2_22187159_ChIP-Seq_PCA_Human1.17720819
69NCOR_22424771_ChIP-Seq_293T_Human1.17567304
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17171336
71AR_20517297_ChIP-Seq_VCAP_Human1.16891397
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16776688
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16189065
74REST_21632747_ChIP-Seq_MESCs_Mouse1.16056805
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.13095232
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13075580
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12101788
78KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11949430
79GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11883062
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11244549
81ETS1_20019798_ChIP-Seq_JURKAT_Human1.09787328
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.09247022
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08807961
84FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08672548
85FOXA1_25329375_ChIP-Seq_VCAP_Human1.08672548
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06709898
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06313055
88FOXH1_21741376_ChIP-Seq_EPCs_Human1.04536831
89TCF4_22108803_ChIP-Seq_LS180_Human1.02752230
90TP53_16413492_ChIP-PET_HCT116_Human1.00985865
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.00228136
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99696019
93IRF1_19129219_ChIP-ChIP_H3396_Human0.99045794
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98919376
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97814126
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.97457871
97RNF2_27304074_Chip-Seq_NSC_Mouse0.96175520
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95800102
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95461325
100SOX9_26525672_Chip-Seq_HEART_Mouse0.92910129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.89249156
2MP0008877_abnormal_DNA_methylation3.95161253
3MP0000569_abnormal_digit_pigmentation3.30361042
4MP0002163_abnormal_gland_morphology3.12958429
5MP0008057_abnormal_DNA_replication3.10442473
6MP0009780_abnormal_chondrocyte_physiolo3.06903207
7MP0001968_abnormal_touch/_nociception3.06486150
8MP0005551_abnormal_eye_electrophysiolog3.04133529
9MP0002876_abnormal_thyroid_physiology2.90944106
10MP0009278_abnormal_bone_marrow2.83289488
11MP0005645_abnormal_hypothalamus_physiol2.68947826
12MP0001501_abnormal_sleep_pattern2.46576420
13MP0005379_endocrine/exocrine_gland_phen2.45014718
14MP0005646_abnormal_pituitary_gland2.37802922
15MP0003880_abnormal_central_pattern2.33463735
16MP0009046_muscle_twitch2.28501408
17MP0008058_abnormal_DNA_repair2.11758040
18MP0002102_abnormal_ear_morphology2.11577157
19MP0006072_abnormal_retinal_apoptosis2.02807444
20MP0009745_abnormal_behavioral_response1.95080725
21MP0003787_abnormal_imprinting1.85761774
22MP0003950_abnormal_plasma_membrane1.83206019
23MP0009764_decreased_sensitivity_to1.78197744
24MP0000015_abnormal_ear_pigmentation1.77116405
25MP0001986_abnormal_taste_sensitivity1.75059049
26MP0006035_abnormal_mitochondrial_morpho1.71842809
27MP0008872_abnormal_physiological_respon1.69562311
28MP0003123_paternal_imprinting1.67954423
29MP0005503_abnormal_tendon_morphology1.52214721
30MP0002272_abnormal_nervous_system1.48584223
31MP0005253_abnormal_eye_physiology1.47072941
32MP0003195_calcinosis1.44534242
33MP0005167_abnormal_blood-brain_barrier1.39483319
34MP0003567_abnormal_fetal_cardiomyocyte1.39442759
35MP0003633_abnormal_nervous_system1.38254928
36MP0001881_abnormal_mammary_gland1.37103390
37MP0003959_abnormal_lean_body1.35613484
38MP0002736_abnormal_nociception_after1.35543692
39MP0005397_hematopoietic_system_phenotyp1.35423962
40MP0001545_abnormal_hematopoietic_system1.35423962
41MP0001664_abnormal_digestion1.34556472
42MP0002160_abnormal_reproductive_system1.33479577
43MP0002735_abnormal_chemical_nociception1.33106523
44MP0009384_cardiac_valve_regurgitation1.32402269
45MP0001348_abnormal_lacrimal_gland1.30968788
46MP0000427_abnormal_hair_cycle1.28918641
47MP0002653_abnormal_ependyma_morphology1.25336162
48MP0000678_abnormal_parathyroid_gland1.24490803
49MP0005386_behavior/neurological_phenoty1.17290259
50MP0004924_abnormal_behavior1.17290259
51MP0005195_abnormal_posterior_eye1.17255675
52MP0005360_urolithiasis1.16229497
53MP0004147_increased_porphyrin_level1.14921821
54MP0002095_abnormal_skin_pigmentation1.14600600
55MP0001919_abnormal_reproductive_system1.14499757
56MP0010234_abnormal_vibrissa_follicle1.14379506
57MP0005174_abnormal_tail_pigmentation1.12841445
58MP0002733_abnormal_thermal_nociception1.11592100
59MP0003646_muscle_fatigue1.09633294
60MP0003119_abnormal_digestive_system1.09484866
61MP0001970_abnormal_pain_threshold1.06917107
62MP0005408_hypopigmentation1.06628179
63MP0001485_abnormal_pinna_reflex1.03772242
64MP0003635_abnormal_synaptic_transmissio1.03637335
65MP0002064_seizures1.00867838
66MP0002229_neurodegeneration1.00587189
67MP0004043_abnormal_pH_regulation1.00380849
68MP0002938_white_spotting0.99983566
69MP0000681_abnormal_thyroid_gland0.98758054
70MP0003936_abnormal_reproductive_system0.98254013
71MP0001486_abnormal_startle_reflex0.97321195
72MP0003879_abnormal_hair_cell0.95665856
73MP0004142_abnormal_muscle_tone0.92205262
74MP0005389_reproductive_system_phenotype0.90431551
75MP0002067_abnormal_sensory_capabilities0.89890785
76MP0000372_irregular_coat_pigmentation0.89180745
77MP0005085_abnormal_gallbladder_physiolo0.88942408
78MP0001984_abnormal_olfaction0.88824487
79MP0003638_abnormal_response/metabolism_0.87498772
80MP0006276_abnormal_autonomic_nervous0.83877151
81MP0003718_maternal_effect0.82671439
82MP0003045_fibrosis0.82669170
83MP0001929_abnormal_gametogenesis0.82528838
84MP0004859_abnormal_synaptic_plasticity0.81086213
85MP0000538_abnormal_urinary_bladder0.80492314
86MP0010094_abnormal_chromosome_stability0.80037171
87MP0005310_abnormal_salivary_gland0.79588934
88MP0002572_abnormal_emotion/affect_behav0.77513500
89MP0004019_abnormal_vitamin_homeostasis0.75974493
90MP0002090_abnormal_vision0.73802461
91MP0003698_abnormal_male_reproductive0.72977142
92MP0003868_abnormal_feces_composition0.71757092
93MP0000230_abnormal_systemic_arterial0.69424248
94MP0000627_abnormal_mammary_gland0.67993747
95MP0001145_abnormal_male_reproductive0.67151514
96MP0000631_abnormal_neuroendocrine_gland0.66692633
97MP0008775_abnormal_heart_ventricle0.66522819
98MP0009765_abnormal_xenobiotic_induced0.65391274
99MP0000358_abnormal_cell_content/0.64664414
100MP0003631_nervous_system_phenotype0.64460561

Predicted human phenotypes

RankGene SetZ-score
1Thyroid-stimulating hormone excess (HP:0002925)6.17949263
2Focal motor seizures (HP:0011153)4.51571912
3Volvulus (HP:0002580)3.96468029
4Large for gestational age (HP:0001520)3.77184347
5Type II lissencephaly (HP:0007260)3.69961078
6Gaze-evoked nystagmus (HP:0000640)3.67857410
73-Methylglutaconic aciduria (HP:0003535)3.62216367
8Intestinal atresia (HP:0011100)3.51873050
9Broad alveolar ridges (HP:0000187)3.50707649
10Lissencephaly (HP:0001339)3.42222324
11Pancreatic islet-cell hyperplasia (HP:0004510)3.40568740
12Carpal bone hypoplasia (HP:0001498)3.33927639
13Pendular nystagmus (HP:0012043)3.21098725
14Abnormality of the ileum (HP:0001549)3.14780054
15Pancreatic cysts (HP:0001737)3.09246296
16Abnormality of alanine metabolism (HP:0010916)3.08625725
17Hyperalaninemia (HP:0003348)3.08625725
18Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08625725
19Cerebellar dysplasia (HP:0007033)3.07130456
20Mesangial abnormality (HP:0001966)2.97585688
21Abnormality of the common coagulation pathway (HP:0010990)2.97279742
22Poor head control (HP:0002421)2.94654064
23Ketoacidosis (HP:0001993)2.94278525
24Abnormality of macular pigmentation (HP:0008002)2.92278002
25Large eyes (HP:0001090)2.88463768
26Abnormality of iron homeostasis (HP:0011031)2.85432863
27Congenital stationary night blindness (HP:0007642)2.84439443
28Focal seizures (HP:0007359)2.82793755
29Tubular atrophy (HP:0000092)2.76316078
30Chromsome breakage (HP:0040012)2.76212659
31Renal cortical cysts (HP:0000803)2.70192258
32Attenuation of retinal blood vessels (HP:0007843)2.69447649
33J-shaped sella turcica (HP:0002680)2.68613166
34Abnormality of the renal cortex (HP:0011035)2.67695463
35Cellular immunodeficiency (HP:0005374)2.67300327
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.65841833
37Pheochromocytoma (HP:0002666)2.65509409
38Pancreatic fibrosis (HP:0100732)2.63086764
39Neuroendocrine neoplasm (HP:0100634)2.61623458
40Abnormality of transition element cation homeostasis (HP:0011030)2.54007226
41Agitation (HP:0000713)2.53154309
42Abnormality of glycolipid metabolism (HP:0010969)2.50174795
43Abnormality of liposaccharide metabolism (HP:0010968)2.50174795
44Abnormality of glycosphingolipid metabolism (HP:0004343)2.50174795
45Hamartoma of the eye (HP:0010568)2.48032310
46True hermaphroditism (HP:0010459)2.38277485
47Increased serum ferritin (HP:0003281)2.38115013
48Severe visual impairment (HP:0001141)2.36105078
49Constricted visual fields (HP:0001133)2.29095455
50Generalized tonic-clonic seizures (HP:0002069)2.27542919
51Abnormal rod and cone electroretinograms (HP:0008323)2.27371618
52Vertebral arch anomaly (HP:0008438)2.26560892
53Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24779038
54Absent rod-and cone-mediated responses on ERG (HP:0007688)2.24264678
55Methylmalonic aciduria (HP:0012120)2.22756938
56Scotoma (HP:0000575)2.20118487
57Optic nerve hypoplasia (HP:0000609)2.18779877
58Conjunctival hamartoma (HP:0100780)2.14209792
59Hypoproteinemia (HP:0003075)2.11361518
60Abnormality of endocrine pancreas physiology (HP:0012093)2.10339432
61Abnormality of the pancreatic islet cells (HP:0006476)2.10339432
62Abnormal albumin level (HP:0012116)2.08062768
63Hypoalbuminemia (HP:0003073)2.08062768
64Neoplasm of the adrenal gland (HP:0100631)2.06903833
65Febrile seizures (HP:0002373)2.05225450
66Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04983130
67Diastasis recti (HP:0001540)2.03434188
68Tetany (HP:0001281)2.02898565
69Meningioma (HP:0002858)2.00278284
70Chorioretinal atrophy (HP:0000533)2.00101775
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99819457
72Abnormality of methionine metabolism (HP:0010901)1.97114791
73Meckel diverticulum (HP:0002245)1.96385717
74Severe Myopia (HP:0011003)1.95107163
75Thickened helices (HP:0000391)1.93978509
76Amelogenesis imperfecta (HP:0000705)1.93595831
77Epileptic encephalopathy (HP:0200134)1.91367203
78Horizontal nystagmus (HP:0000666)1.90524328
79Hip dysplasia (HP:0001385)1.88708405
80Furrowed tongue (HP:0000221)1.88136558
81Duplicated collecting system (HP:0000081)1.87225918
82Dialeptic seizures (HP:0011146)1.85345985
83Oligodontia (HP:0000677)1.83889426
84Hemiparesis (HP:0001269)1.80572468
85Goiter (HP:0000853)1.78563369
86Abnormality of the renal collecting system (HP:0004742)1.78136702
87Anterior segment dysgenesis (HP:0007700)1.77539319
88Abnormal drinking behavior (HP:0030082)1.77361404
89Polydipsia (HP:0001959)1.77361404
90Abnormality of the vitreous humor (HP:0004327)1.77272694
91Flared iliac wings (HP:0002869)1.76848122
92Abnormal hair laboratory examination (HP:0003328)1.76755717
93Non-midline cleft lip (HP:0100335)1.76611675
94Abnormality of the alveolar ridges (HP:0006477)1.76044743
95Neoplasm of the adrenal cortex (HP:0100641)1.75876077
96Abnormality of the aortic arch (HP:0012303)1.75717940
97Hamartoma (HP:0010566)1.75475718
98Hepatitis (HP:0012115)1.75324870
99Congenital ichthyosiform erythroderma (HP:0007431)1.75269542
100Abnormality of the renal medulla (HP:0100957)1.73731292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.05141900
2ADRBK25.81171540
3PNCK3.44734584
4PDK23.17290066
5MARK12.62092144
6NUAK12.35684435
7SRPK12.19689530
8IRAK32.13797416
9CAMKK22.11605540
10LATS12.09880144
11INSRR1.89805318
12NTRK31.86708613
13TYRO31.86107242
14ZAK1.83976886
15PINK11.68700927
16ADRBK11.67245872
17KIT1.64008475
18DYRK31.63623507
19MAP2K61.46718084
20ACVR1B1.45537987
21TSSK61.45263426
22MKNK11.40823155
23PAK31.39991159
24AKT21.38882042
25BMPR1B1.37111343
26CAMK1G1.33141049
27TGFBR11.30465453
28EPHA41.27954627
29MKNK21.24069987
30YES11.19910754
31DYRK21.18481413
32CAMK11.14468081
33WNK41.08297585
34PRKCG1.07493558
35PTK2B1.03209059
36BCR1.03102881
37STK38L1.02648101
38CCNB11.02180246
39TAF10.97522706
40EIF2AK30.92774045
41IRAK10.87211693
42CAMK40.85496207
43PLK30.85268236
44TAOK30.85257116
45CAMK2A0.84125933
46PLK20.82333016
47FLT30.79359502
48PRKCE0.79156526
49WNK30.78196225
50WEE10.75870338
51STK30.75862036
52GRK10.71278133
53PLK40.70717068
54SCYL20.67758244
55MAPK130.63751467
56STK160.61415135
57CLK10.61256659
58TRIM280.60502444
59EIF2AK10.60240469
60MINK10.55123030
61STK380.54612106
62STK390.52941251
63MAPKAPK50.51385047
64MUSK0.49330974
65MAPK110.47846081
66TXK0.47402752
67CSF1R0.45625004
68ERBB20.45157259
69GRK50.44591221
70ERN10.44550729
71MET0.44340010
72OXSR10.43278103
73TYK20.42679227
74ATM0.41054346
75TEC0.40599644
76CSNK1G20.40593097
77IKBKB0.40229403
78CAMKK10.39786884
79PASK0.39155223
80CSNK1A10.38040885
81CSNK1E0.37573356
82FGFR20.36663058
83VRK10.35028894
84NME10.34907087
85EIF2AK20.34352945
86TIE10.32460870
87CHEK20.32309623
88PKN10.32059620
89CSNK1G30.31655507
90PRKCB0.31328700
91MAP4K20.30516834
92CSNK2A20.29564779
93ABL10.29489550
94MAPK120.28641772
95DYRK1A0.28355907
96PIK3CG0.26306071
97PRKCA0.26080328
98CSNK1A1L0.25491238
99NEK60.23972650
100IGF1R0.22879307

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.66841148
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.50989306
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.90885191
4Homologous recombination_Homo sapiens_hsa034402.86267320
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.84346067
6Nitrogen metabolism_Homo sapiens_hsa009102.54549100
7Olfactory transduction_Homo sapiens_hsa047402.48631364
8Butanoate metabolism_Homo sapiens_hsa006502.36866076
9Linoleic acid metabolism_Homo sapiens_hsa005912.36705858
10Non-homologous end-joining_Homo sapiens_hsa034502.34594947
11Fanconi anemia pathway_Homo sapiens_hsa034602.33213145
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.12415383
13Caffeine metabolism_Homo sapiens_hsa002322.02836624
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.01223598
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93828439
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93772252
17Sulfur relay system_Homo sapiens_hsa041221.93714619
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.89960257
19Tryptophan metabolism_Homo sapiens_hsa003801.83819665
20Protein export_Homo sapiens_hsa030601.79583859
21RNA polymerase_Homo sapiens_hsa030201.72642406
22Dorso-ventral axis formation_Homo sapiens_hsa043201.64725336
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.55841050
24Basal transcription factors_Homo sapiens_hsa030221.53627122
25Taste transduction_Homo sapiens_hsa047421.49529115
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.45575695
27ABC transporters_Homo sapiens_hsa020101.41825951
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.39988106
29Morphine addiction_Homo sapiens_hsa050321.39590725
30Glycerolipid metabolism_Homo sapiens_hsa005611.34234793
31RNA degradation_Homo sapiens_hsa030181.33400235
32Purine metabolism_Homo sapiens_hsa002301.32068744
33Nicotine addiction_Homo sapiens_hsa050331.29179550
34Selenocompound metabolism_Homo sapiens_hsa004501.27473709
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27051905
36Ovarian steroidogenesis_Homo sapiens_hsa049131.26387144
37Parkinsons disease_Homo sapiens_hsa050121.23994335
38Oxidative phosphorylation_Homo sapiens_hsa001901.15265617
39One carbon pool by folate_Homo sapiens_hsa006701.09420017
40Arachidonic acid metabolism_Homo sapiens_hsa005901.08286406
41Fatty acid degradation_Homo sapiens_hsa000711.07734778
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.06963262
43Huntingtons disease_Homo sapiens_hsa050161.04561117
44Sphingolipid metabolism_Homo sapiens_hsa006001.01053396
45Propanoate metabolism_Homo sapiens_hsa006401.00210381
46Ether lipid metabolism_Homo sapiens_hsa005650.95008914
47Collecting duct acid secretion_Homo sapiens_hsa049660.93345115
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87954661
49Calcium signaling pathway_Homo sapiens_hsa040200.83744439
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80617575
51Glutamatergic synapse_Homo sapiens_hsa047240.79521706
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74959973
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73886874
54RNA transport_Homo sapiens_hsa030130.73637696
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72808753
56Long-term depression_Homo sapiens_hsa047300.72741903
57Pyrimidine metabolism_Homo sapiens_hsa002400.71998947
58beta-Alanine metabolism_Homo sapiens_hsa004100.69384629
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.67838926
60Histidine metabolism_Homo sapiens_hsa003400.66690195
61Primary immunodeficiency_Homo sapiens_hsa053400.65396854
62Retinol metabolism_Homo sapiens_hsa008300.64414384
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.63260966
64Circadian entrainment_Homo sapiens_hsa047130.59936289
65Proteasome_Homo sapiens_hsa030500.59687881
66Mineral absorption_Homo sapiens_hsa049780.59292416
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59213542
68Metabolic pathways_Homo sapiens_hsa011000.57735871
69Serotonergic synapse_Homo sapiens_hsa047260.55311073
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.55169157
71Mismatch repair_Homo sapiens_hsa034300.54171354
72Nucleotide excision repair_Homo sapiens_hsa034200.53283891
73Base excision repair_Homo sapiens_hsa034100.53203437
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52414877
75Chemical carcinogenesis_Homo sapiens_hsa052040.51125640
76Fatty acid metabolism_Homo sapiens_hsa012120.50614246
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50208443
78Ribosome_Homo sapiens_hsa030100.48779505
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.46889565
80Cardiac muscle contraction_Homo sapiens_hsa042600.46075308
81Peroxisome_Homo sapiens_hsa041460.45447966
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44327719
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43520944
84GABAergic synapse_Homo sapiens_hsa047270.42381025
85Alzheimers disease_Homo sapiens_hsa050100.41648798
86Steroid biosynthesis_Homo sapiens_hsa001000.39341958
87Salivary secretion_Homo sapiens_hsa049700.38629929
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.35694660
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34193495
90mRNA surveillance pathway_Homo sapiens_hsa030150.33718297
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.32596875
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32549566
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31418066
94Amphetamine addiction_Homo sapiens_hsa050310.30479818
95Folate biosynthesis_Homo sapiens_hsa007900.29419512
96cAMP signaling pathway_Homo sapiens_hsa040240.29083153
97DNA replication_Homo sapiens_hsa030300.28622113
98Pyruvate metabolism_Homo sapiens_hsa006200.28207857
99Fatty acid biosynthesis_Homo sapiens_hsa000610.28012066
100Hedgehog signaling pathway_Homo sapiens_hsa043400.26524497

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