PAICSP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA damage response, detection of DNA damage (GO:0042769)9.06144612
2regulation of telomerase activity (GO:0051972)7.78083337
3ventricular trabecula myocardium morphogenesis (GO:0003222)7.67970240
4telomere maintenance via telomerase (GO:0007004)7.37579325
5negative regulation of DNA biosynthetic process (GO:2000279)6.81339318
6regulation of telomere maintenance (GO:0032204)6.74108717
7heart trabecula morphogenesis (GO:0061384)6.47572527
8negative regulation of cardiac muscle cell apoptotic process (GO:0010667)6.41655300
9lymphangiogenesis (GO:0001946)5.83313262
10positive regulation of cellular response to oxidative stress (GO:1900409)5.60143579
11positive regulation of response to oxidative stress (GO:1902884)5.60143579
12artery development (GO:0060840)5.55710205
13RNA-dependent DNA replication (GO:0006278)5.23427468
14cardiac right ventricle morphogenesis (GO:0003215)5.00590991
15positive regulation of DNA biosynthetic process (GO:2000573)4.85023529
16trabecula morphogenesis (GO:0061383)4.80814225
17regulation of cardiac muscle cell apoptotic process (GO:0010665)4.72437505
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.67624224
19NADH dehydrogenase complex assembly (GO:0010257)4.67624224
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.67624224
21endothelial cell differentiation (GO:0045446)4.34142549
22embryonic foregut morphogenesis (GO:0048617)4.26674150
23organ growth (GO:0035265)4.16410733
24negative regulation of striated muscle cell apoptotic process (GO:0010664)4.15587946
25response to ischemia (GO:0002931)4.15474297
26interkinetic nuclear migration (GO:0022027)3.84948617
27superoxide anion generation (GO:0042554)3.77945286
28renal system development (GO:0072001)3.73031737
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.71912307
30protein complex biogenesis (GO:0070271)3.67835536
31regulation of striated muscle cell apoptotic process (GO:0010662)3.64162406
32activin receptor signaling pathway (GO:0032924)3.61957375
33ventricular cardiac muscle cell development (GO:0055015)3.57324453
34regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.55321669
35mitochondrial respiratory chain complex assembly (GO:0033108)3.45115351
36cullin deneddylation (GO:0010388)3.44337768
37retina development in camera-type eye (GO:0060041)3.44245983
38resolution of meiotic recombination intermediates (GO:0000712)3.42601973
39cell adhesion mediated by integrin (GO:0033627)3.39730273
40cerebral cortex neuron differentiation (GO:0021895)3.36232963
41regulation of protein heterodimerization activity (GO:0043497)3.35968307
42DNA replication checkpoint (GO:0000076)3.32449532
43gastrulation with mouth forming second (GO:0001702)3.29423366
44cell migration in hindbrain (GO:0021535)3.23096513
45response to acidic pH (GO:0010447)3.21443137
46secondary heart field specification (GO:0003139)3.17802395
47heart field specification (GO:0003128)3.17802395
48C4-dicarboxylate transport (GO:0015740)3.14920426
49intra-S DNA damage checkpoint (GO:0031573)3.11813194
50protein deneddylation (GO:0000338)3.08569823
51single strand break repair (GO:0000012)3.06811232
52exogenous drug catabolic process (GO:0042738)3.02720404
53protein polyglutamylation (GO:0018095)2.99489682
54telomere maintenance via telomere lengthening (GO:0010833)2.92943352
55otic vesicle formation (GO:0030916)2.92615067
56cell proliferation in forebrain (GO:0021846)2.92467352
57negative regulation of DNA replication (GO:0008156)2.90333442
58transmission of nerve impulse (GO:0019226)2.90131242
59CENP-A containing nucleosome assembly (GO:0034080)2.89055533
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88632183
61lateral ventricle development (GO:0021670)2.88432002
62chromatin remodeling at centromere (GO:0031055)2.87579829
63positive regulation of TOR signaling (GO:0032008)2.84915194
64hemidesmosome assembly (GO:0031581)2.83867091
65positive regulation of cardiac muscle tissue growth (GO:0055023)2.81761571
66brain morphogenesis (GO:0048854)2.78600963
67activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.77454899
68negative regulation of protein localization to cell surface (GO:2000009)2.76122612
69replication fork processing (GO:0031297)2.76071846
70protein localization to vacuole (GO:0072665)2.75305226
71protein localization to lysosome (GO:0061462)2.75305226
72histone-serine phosphorylation (GO:0035404)2.73574710
73nucleotide transmembrane transport (GO:1901679)2.70446548
74positive regulation of cardiac muscle cell proliferation (GO:0060045)2.68821161
75negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.66433836
76adenosine metabolic process (GO:0046085)2.62975133
77limb bud formation (GO:0060174)2.59537430
78cellular response to pH (GO:0071467)2.57107061
79GTP biosynthetic process (GO:0006183)2.53238514
80positive regulation of Rho protein signal transduction (GO:0035025)2.51988958
81positive regulation of heart growth (GO:0060421)2.51253021
82regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.51060416
83microtubule anchoring (GO:0034453)2.48465806
84platelet dense granule organization (GO:0060155)2.47648827
85drug catabolic process (GO:0042737)2.45795038
86response to pheromone (GO:0019236)2.43966886
87cardiac muscle contraction (GO:0060048)2.43280543
88negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.43037835
89apoptotic DNA fragmentation (GO:0006309)2.40465851
90histone exchange (GO:0043486)2.40186449
91filopodium assembly (GO:0046847)2.35159213
92DNA catabolic process, exonucleolytic (GO:0000738)2.34881505
93type B pancreatic cell development (GO:0003323)2.33644437
94regulation of smooth muscle cell differentiation (GO:0051150)2.33482635
95viral genome replication (GO:0019079)2.31313819
96regulation of telomere maintenance via telomerase (GO:0032210)12.5305501
97negative regulation of telomerase activity (GO:0051974)11.8585075
98negative regulation of telomere maintenance (GO:0032205)11.4003985
99DNA damage induced protein phosphorylation (GO:0006975)11.2853553
100regulation of helicase activity (GO:0051095)10.2334002

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse7.71491386
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.73768198
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse5.32755267
4GBX2_23144817_ChIP-Seq_PC3_Human3.71154236
5HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.66990203
6E2F7_22180533_ChIP-Seq_HELA_Human3.36857382
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.48094461
8EWS_26573619_Chip-Seq_HEK293_Human2.38962984
9FUS_26573619_Chip-Seq_HEK293_Human2.35046888
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.23603880
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.23495012
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.20511470
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16407024
14TAF15_26573619_Chip-Seq_HEK293_Human2.14810530
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10788866
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09159686
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07071709
18VDR_22108803_ChIP-Seq_LS180_Human2.06543380
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.03140742
20ZNF274_21170338_ChIP-Seq_K562_Hela2.01753194
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89645160
22AR_21572438_ChIP-Seq_LNCaP_Human1.81923969
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.78947591
24TP63_19390658_ChIP-ChIP_HaCaT_Human1.78644175
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77874068
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75335410
27MYC_18940864_ChIP-ChIP_HL60_Human1.64622821
28TP53_16413492_ChIP-PET_HCT116_Human1.64083837
29IGF1R_20145208_ChIP-Seq_DFB_Human1.62183577
30P300_19829295_ChIP-Seq_ESCs_Human1.58882773
31ER_23166858_ChIP-Seq_MCF-7_Human1.54900316
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.52746018
33POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48267201
34STAT3_23295773_ChIP-Seq_U87_Human1.46531805
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.46442839
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.45051357
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44490630
38CBP_20019798_ChIP-Seq_JUKART_Human1.44490630
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43330080
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43330080
41LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39794226
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37451166
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36338287
44ELK1_19687146_ChIP-ChIP_HELA_Human1.34124301
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33541829
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32226697
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31128449
48EZH2_22144423_ChIP-Seq_EOC_Human1.30816899
49SMAD4_21799915_ChIP-Seq_A2780_Human1.30592601
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.28947935
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28251947
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27110555
53REST_21632747_ChIP-Seq_MESCs_Mouse1.25208608
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23395543
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21695364
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20984702
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20772693
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20307116
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20172163
60CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19743227
61TCF4_22108803_ChIP-Seq_LS180_Human1.17340755
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.14644650
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14054725
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.10845918
65TP63_17297297_ChIP-ChIP_HaCaT_Human1.10675676
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.08075458
67RUNX2_22187159_ChIP-Seq_PCA_Human1.08046163
68TCF4_23295773_ChIP-Seq_U87_Human1.07436087
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07057334
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06623157
71TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06273317
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04255471
73TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04214695
74TP53_22573176_ChIP-Seq_HFKS_Human1.04184368
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04148519
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04118627
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.02573557
78GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01352670
79AR_25329375_ChIP-Seq_VCAP_Human0.95584199
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95285475
81CREB1_15753290_ChIP-ChIP_HEK293T_Human0.94835153
82P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93500505
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93034710
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.92487285
85RNF2_27304074_Chip-Seq_NSC_Mouse0.92376606
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.92029924
87IRF1_19129219_ChIP-ChIP_H3396_Human0.90757642
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90663691
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.90379210
90NCOR_22424771_ChIP-Seq_293T_Human0.89659438
91PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89111635
92CMYC_18555785_Chip-Seq_ESCs_Mouse0.88139610
93BCAT_22108803_ChIP-Seq_LS180_Human0.87785196
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86815768
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85018994
96NANOG_18555785_Chip-Seq_ESCs_Mouse0.84513841
97TAL1_26923725_Chip-Seq_HPCs_Mouse0.83770369
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83425694
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81829788
100P53_22387025_ChIP-Seq_ESCs_Mouse0.81645047

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002163_abnormal_gland_morphology4.56447674
2MP0004133_heterotaxia4.52102392
3MP0003880_abnormal_central_pattern3.75228950
4MP0004270_analgesia3.61704296
5MP0002102_abnormal_ear_morphology3.19998616
6MP0009697_abnormal_copulation3.17027820
7MP0002127_abnormal_cardiovascular_syste3.12093864
8MP0003646_muscle_fatigue2.91708000
9MP0006276_abnormal_autonomic_nervous2.73638120
10MP0004147_increased_porphyrin_level2.59288941
11MP0008775_abnormal_heart_ventricle2.53966971
12MP0005379_endocrine/exocrine_gland_phen2.53658007
13MP0006072_abnormal_retinal_apoptosis2.53291263
14MP0002736_abnormal_nociception_after2.37410794
15MP0005595_abnormal_vascular_smooth2.19732031
16MP0008875_abnormal_xenobiotic_pharmacok2.00025604
17MP0004145_abnormal_muscle_electrophysio1.96613586
18MP0003763_abnormal_thymus_physiology1.89620608
19MP0000778_abnormal_nervous_system1.85015469
20MP0009745_abnormal_behavioral_response1.77339722
21MP0001529_abnormal_vocalization1.71048368
22MP0000647_abnormal_sebaceous_gland1.70984696
23MP0001968_abnormal_touch/_nociception1.70174821
24MP0001485_abnormal_pinna_reflex1.69154151
25MP0003890_abnormal_embryonic-extraembry1.64683292
26MP0000631_abnormal_neuroendocrine_gland1.64490943
27MP0003806_abnormal_nucleotide_metabolis1.59962101
28MP0005551_abnormal_eye_electrophysiolog1.50383728
29MP0005646_abnormal_pituitary_gland1.47314262
30MP0008057_abnormal_DNA_replication1.44534022
31MP0005645_abnormal_hypothalamus_physiol1.44050434
32MP0004272_abnormal_basement_membrane1.35530057
33MP0006292_abnormal_olfactory_placode1.34639168
34MP0004484_altered_response_of1.31110139
35MP0002734_abnormal_mechanical_nocicepti1.31082037
36MP0005075_abnormal_melanosome_morpholog1.29702605
37MP0002272_abnormal_nervous_system1.28823480
38MP0002184_abnormal_innervation1.28666848
39MP0003195_calcinosis1.28369621
40MP0004883_abnormal_blood_vessel1.27296242
41MP0000749_muscle_degeneration1.26841344
42MP0002064_seizures1.25312454
43MP0000566_synostosis1.21643187
44MP0003635_abnormal_synaptic_transmissio1.20469717
45MP0008877_abnormal_DNA_methylation1.20447466
46MP0003693_abnormal_embryo_hatching1.20152650
47MP0002972_abnormal_cardiac_muscle1.16065153
48MP0005620_abnormal_muscle_contractility1.13642122
49MP0005195_abnormal_posterior_eye1.11704593
50MP0004742_abnormal_vestibular_system1.10790766
51MP0003137_abnormal_impulse_conducting1.08734630
52MP0002168_other_aberrant_phenotype1.06552942
53MP0004084_abnormal_cardiac_muscle1.03315107
54MP0001963_abnormal_hearing_physiology1.02806887
55MP0010094_abnormal_chromosome_stability1.02502058
56MP0002751_abnormal_autonomic_nervous1.02413031
57MP0009379_abnormal_foot_pigmentation1.01061240
58MP0008872_abnormal_physiological_respon1.00636110
59MP0005171_absent_coat_pigmentation0.98252869
60MP0003221_abnormal_cardiomyocyte_apopto0.98031520
61MP0002089_abnormal_postnatal_growth/wei0.97570193
62MP0003448_altered_tumor_morphology0.96721703
63MP0005197_abnormal_uvea_morphology0.95616809
64MP0003718_maternal_effect0.92311484
65MP0008874_decreased_physiological_sensi0.92212462
66MP0003186_abnormal_redox_activity0.89164313
67MP0004043_abnormal_pH_regulation0.88766658
68MP0002557_abnormal_social/conspecific_i0.87383221
69MP0005253_abnormal_eye_physiology0.86258599
70MP0001501_abnormal_sleep_pattern0.86196483
71MP0004885_abnormal_endolymph0.84642609
72MP0001764_abnormal_homeostasis0.83772056
73MP0005395_other_phenotype0.83545102
74MP0009250_abnormal_appendicular_skeleto0.82729422
75MP0004811_abnormal_neuron_physiology0.79926083
76MP0008995_early_reproductive_senescence0.79535821
77MP0000049_abnormal_middle_ear0.79309603
78MP0002063_abnormal_learning/memory/cond0.78919391
79MP0000372_irregular_coat_pigmentation0.78539236
80MP0001970_abnormal_pain_threshold0.77001093
81MP0002233_abnormal_nose_morphology0.76396544
82MP0002733_abnormal_thermal_nociception0.74653920
83MP0005085_abnormal_gallbladder_physiolo0.74519643
84MP0005332_abnormal_amino_acid0.74221291
85MP0000230_abnormal_systemic_arterial0.74095936
86MP0002111_abnormal_tail_morphology0.73537210
87MP0001544_abnormal_cardiovascular_syste0.72903546
88MP0005385_cardiovascular_system_phenoty0.72903546
89MP0005330_cardiomyopathy0.72495270
90MP0000427_abnormal_hair_cycle0.71255619
91MP0002752_abnormal_somatic_nervous0.70459704
92MP0004215_abnormal_myocardial_fiber0.70166623
93MP0002095_abnormal_skin_pigmentation0.66589054
94MP0005389_reproductive_system_phenotype0.66430542
95MP0001919_abnormal_reproductive_system0.66186942
96MP0005386_behavior/neurological_phenoty0.65835275
97MP0004924_abnormal_behavior0.65835275
98MP0003077_abnormal_cell_cycle0.65176838
99MP0002572_abnormal_emotion/affect_behav0.63971248
100MP0008058_abnormal_DNA_repair0.61735131

Predicted human phenotypes

RankGene SetZ-score
1Esophageal atresia (HP:0002032)7.83740011
2Increased serum pyruvate (HP:0003542)6.73483870
3Aplasia cutis congenita (HP:0001057)6.32706641
4Abnormality of the aortic arch (HP:0012303)6.15806985
5Abnormality of glycolysis (HP:0004366)5.81297093
6Gastrointestinal atresia (HP:0002589)5.41393577
7Hyperventilation (HP:0002883)4.61528316
8Atonic seizures (HP:0010819)4.39713756
9Colon cancer (HP:0003003)3.78703334
10Abnormality of the labia minora (HP:0012880)3.60846293
11Ureteral stenosis (HP:0000071)3.48576549
12Ureteral obstruction (HP:0006000)3.35364615
13Increased CSF lactate (HP:0002490)3.31018848
14Increased connective tissue (HP:0009025)3.28355896
15Melanoma (HP:0002861)3.28090317
16Nephronophthisis (HP:0000090)3.23025656
17Chronic hepatic failure (HP:0100626)3.12636402
18Hepatocellular necrosis (HP:0001404)3.06685892
19Milia (HP:0001056)3.03477766
20Molar tooth sign on MRI (HP:0002419)2.89295809
21Abnormality of midbrain morphology (HP:0002418)2.89295809
22Freckling (HP:0001480)2.81513655
23Small intestinal stenosis (HP:0012848)2.75926796
24Duodenal stenosis (HP:0100867)2.75926796
25Pterygium (HP:0001059)2.73140833
26Ectropion (HP:0000656)2.66864054
27Mitochondrial inheritance (HP:0001427)2.66134134
28Asplenia (HP:0001746)2.61305031
29Hepatic necrosis (HP:0002605)2.60423916
30Dialeptic seizures (HP:0011146)2.56338167
31Focal seizures (HP:0007359)2.55369887
32Aplasia/Hypoplasia of the spleen (HP:0010451)2.48669860
33Absence seizures (HP:0002121)2.47025607
34Inability to walk (HP:0002540)2.41201059
35Atrioventricular canal defect (HP:0006695)2.39598022
36Status epilepticus (HP:0002133)2.37979771
37Ragged-red muscle fibers (HP:0003200)2.35823500
38Hypokinesia (HP:0002375)2.35644206
39Abnormality of the renal medulla (HP:0100957)2.34742027
40Abnormality of the duodenum (HP:0002246)2.31150628
41Pancreatic cysts (HP:0001737)2.26129194
42Focal motor seizures (HP:0011153)2.13277346
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.13207591
44Neoplasm of the pancreas (HP:0002894)2.12388453
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.11746578
46Optic nerve hypoplasia (HP:0000609)2.11157202
47Atrophic scars (HP:0001075)2.11075361
48Increased serum lactate (HP:0002151)2.09993538
49Tetraplegia (HP:0002445)2.09210643
50Curly hair (HP:0002212)2.08812262
51Fragile skin (HP:0001030)2.06596036
52Intrahepatic cholestasis (HP:0001406)2.05835991
53Abnormality of the prostate (HP:0008775)2.02943431
54True hermaphroditism (HP:0010459)2.02476467
55Severe combined immunodeficiency (HP:0004430)1.98343209
56Broad-based gait (HP:0002136)1.90712769
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.89950533
58Acute necrotizing encephalopathy (HP:0006965)1.87558455
59Thyroiditis (HP:0100646)1.85578377
60CNS demyelination (HP:0007305)1.82600674
61Renal cortical cysts (HP:0000803)1.82151886
62Stenosis of the external auditory canal (HP:0000402)1.81991463
63Abolished electroretinogram (ERG) (HP:0000550)1.80742281
64Symphalangism affecting the phalanges of the hand (HP:0009773)1.79668262
65Congenital stationary night blindness (HP:0007642)1.76880377
66Panhypogammaglobulinemia (HP:0003139)1.76568058
67High anterior hairline (HP:0009890)1.76250419
68Hip dysplasia (HP:0001385)1.74653432
69Papillary thyroid carcinoma (HP:0002895)1.72920972
70Retinopathy (HP:0000488)1.72439322
71Stomach cancer (HP:0012126)1.72079558
72Renal Fanconi syndrome (HP:0001994)1.70648772
73Patellar aplasia (HP:0006443)1.70250096
74Pendular nystagmus (HP:0012043)1.66924911
75Amblyopia (HP:0000646)1.66584655
76Neoplasm of the adrenal cortex (HP:0100641)1.66120019
77Abnormality of the ileum (HP:0001549)1.65173443
78Fibular aplasia (HP:0002990)1.64744162
79Abnormality of the renal cortex (HP:0011035)1.64374377
80Hypoplastic pelvis (HP:0008839)1.63844332
81Hypoplasia of the fovea (HP:0007750)1.63797583
82Aplasia/Hypoplasia of the fovea (HP:0008060)1.63797583
83Chorioretinal coloboma (HP:0000567)1.62634655
84Opisthotonus (HP:0002179)1.62318948
85Increased density of long bones (HP:0006392)1.61206877
86Acute encephalopathy (HP:0006846)1.61065662
87Delayed CNS myelination (HP:0002188)1.61047495
88Meckel diverticulum (HP:0002245)1.58297726
89Increased hepatocellular lipid droplets (HP:0006565)1.58201669
90Fair hair (HP:0002286)1.57091541
91Aplasia/Hypoplasia of the patella (HP:0006498)1.56897056
92Blue irides (HP:0000635)1.51755445
93Septo-optic dysplasia (HP:0100842)1.51673831
94Optic disc pallor (HP:0000543)1.51523554
95Wide intermamillary distance (HP:0006610)1.50786348
96Synostosis involving the elbow (HP:0003938)1.50692633
97Humeroradial synostosis (HP:0003041)1.50692633
98Abnormality of the fovea (HP:0000493)1.49452696
99Progressive macrocephaly (HP:0004481)1.49384505
100Shoulder girdle muscle weakness (HP:0003547)1.48572528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K66.04618280
2TLK15.57996357
3MAP3K53.81247958
4MAP4K23.42377713
5SIK22.31131996
6NME12.02904758
7TAOK211.3698909
8VRK21.93055671
9NEK11.82779031
10FRK1.64656064
11CASK1.64376069
12TAF11.33802858
13MAP3K81.25173182
14WNK31.18676634
15NUAK11.17078160
16MST41.09392523
17MAPKAPK30.94699958
18PLK40.91642795
19STK390.88903578
20ZAK0.88808253
21PIK3CA0.88696075
22MARK10.87411425
23VRK10.86537190
24MAPKAPK50.83770991
25EIF2AK30.83334128
26MAP3K40.82778706
27OXSR10.81984783
28TSSK60.81144265
29RIPK10.80771101
30MAPK130.77322618
31WNK40.76194262
32CCNB10.70191427
33MAP2K70.68604283
34TNIK0.68422108
35TTK0.64729845
36BUB10.62840389
37PLK30.60478582
38ADRBK20.55475663
39STK40.50423020
40TXK0.47662221
41EIF2AK10.47101075
42MELK0.45108142
43TAOK30.43298837
44GRK50.42672843
45CSNK1G20.41221352
46GRK10.39783127
47NLK0.38818225
48PLK20.38461276
49FGFR20.38447790
50CSNK1G30.38235525
51MKNK20.37924048
52PASK0.37907898
53PAK30.37367227
54DYRK20.37101487
55EPHA40.36657970
56BLK0.35373936
57HIPK20.31764088
58EIF2AK20.30301274
59CSNK1A1L0.30115458
60SRPK10.26961535
61RPS6KB20.26796264
62MKNK10.26628118
63PRKCG0.25963095
64EEF2K0.25025812
65CAMK40.25023748
66RIPK40.24347999
67BCR0.23410331
68WEE10.23157223
69CSNK1G10.21970878
70ATR0.21241996
71INSRR0.20855867
72SIK30.20709899
73MINK10.20521432
74TRIM280.20049366
75TRPM70.19675410
76CHEK20.19578917
77DAPK10.18908852
78PKN10.17486894
79MAP3K60.16648234
80AURKA0.15222075
81EPHA30.15040687
82TEC0.14396572
83RPS6KA50.14029426
84GRK70.12080636
85CSNK1A10.11118822
86CAMK10.10744404
87AURKB0.10420957
88CDC70.10413154
89CDK80.09554551
90PBK0.09292119
91MAP2K40.08846401
92CSNK2A10.06794423
93ADRBK10.05904740
94PRKCQ0.05762892
95MAPK70.05620763
96PIK3CG0.05586860
97PLK10.05521269
98PRKCE0.04878817
99PRKACB0.04644611
100DYRK1A0.03187753

Predicted pathways (KEGG)

RankGene SetZ-score
1Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.97702338
2Proteasome_Homo sapiens_hsa030502.77898688
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.41603489
4Parkinsons disease_Homo sapiens_hsa050122.41379260
5Oxidative phosphorylation_Homo sapiens_hsa001902.40859372
6RNA polymerase_Homo sapiens_hsa030202.24773817
7Phototransduction_Homo sapiens_hsa047442.19243812
8Homologous recombination_Homo sapiens_hsa034402.16395451
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04380992
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.96100934
11Butanoate metabolism_Homo sapiens_hsa006501.94673311
12Fanconi anemia pathway_Homo sapiens_hsa034601.94429733
13Basal transcription factors_Homo sapiens_hsa030221.93089271
14Nicotine addiction_Homo sapiens_hsa050331.82365467
15One carbon pool by folate_Homo sapiens_hsa006701.78581515
16Systemic lupus erythematosus_Homo sapiens_hsa053221.72951960
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69161597
18Huntingtons disease_Homo sapiens_hsa050161.65202582
19Alzheimers disease_Homo sapiens_hsa050101.64807502
20Non-homologous end-joining_Homo sapiens_hsa034501.64373564
21Cocaine addiction_Homo sapiens_hsa050301.64004459
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56930157
23RNA degradation_Homo sapiens_hsa030181.54592031
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.52661078
25Propanoate metabolism_Homo sapiens_hsa006401.47909251
26Pyrimidine metabolism_Homo sapiens_hsa002401.46954031
27Mismatch repair_Homo sapiens_hsa034301.46784112
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44512970
29Protein export_Homo sapiens_hsa030601.43764619
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42888690
31Cardiac muscle contraction_Homo sapiens_hsa042601.31491281
32Selenocompound metabolism_Homo sapiens_hsa004501.28689917
33Purine metabolism_Homo sapiens_hsa002301.28423495
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24658431
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24021924
36RNA transport_Homo sapiens_hsa030131.22499830
37GnRH signaling pathway_Homo sapiens_hsa049121.21985862
38Salivary secretion_Homo sapiens_hsa049701.20587993
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19592960
40DNA replication_Homo sapiens_hsa030301.19128869
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.18652508
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.15548533
43Nucleotide excision repair_Homo sapiens_hsa034201.15007352
44Linoleic acid metabolism_Homo sapiens_hsa005911.08428083
45Caffeine metabolism_Homo sapiens_hsa002321.06771803
46Dilated cardiomyopathy_Homo sapiens_hsa054141.06516782
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.03551370
48Primary immunodeficiency_Homo sapiens_hsa053401.02674212
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00597464
50Alcoholism_Homo sapiens_hsa050340.99182233
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98966310
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.97352973
53Spliceosome_Homo sapiens_hsa030400.91902251
54Olfactory transduction_Homo sapiens_hsa047400.89146080
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87408928
56Toxoplasmosis_Homo sapiens_hsa051450.86686131
57TGF-beta signaling pathway_Homo sapiens_hsa043500.86007495
58Nitrogen metabolism_Homo sapiens_hsa009100.83685201
59Circadian entrainment_Homo sapiens_hsa047130.83022243
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82160586
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.79542516
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78047529
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77854839
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76628037
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74487396
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73175517
67Ribosome_Homo sapiens_hsa030100.71050162
68Vitamin B6 metabolism_Homo sapiens_hsa007500.66338433
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65932481
70Ether lipid metabolism_Homo sapiens_hsa005650.61756235
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59669039
72mRNA surveillance pathway_Homo sapiens_hsa030150.59335240
73Circadian rhythm_Homo sapiens_hsa047100.58724501
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56955894
75Taste transduction_Homo sapiens_hsa047420.56252461
76Retinol metabolism_Homo sapiens_hsa008300.56029606
77Dorso-ventral axis formation_Homo sapiens_hsa043200.55320048
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55303810
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54851475
80beta-Alanine metabolism_Homo sapiens_hsa004100.54790183
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53724266
82Wnt signaling pathway_Homo sapiens_hsa043100.52517723
83Glutamatergic synapse_Homo sapiens_hsa047240.52050416
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51093678
85Arachidonic acid metabolism_Homo sapiens_hsa005900.48333857
86Basal cell carcinoma_Homo sapiens_hsa052170.47853708
87Rap1 signaling pathway_Homo sapiens_hsa040150.47248290
88Arginine biosynthesis_Homo sapiens_hsa002200.44166971
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43524757
90Glutathione metabolism_Homo sapiens_hsa004800.42014218
91Oocyte meiosis_Homo sapiens_hsa041140.41763773
92MAPK signaling pathway_Homo sapiens_hsa040100.40669896
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39139140
94Metabolic pathways_Homo sapiens_hsa011000.38709401
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.38345960
96GABAergic synapse_Homo sapiens_hsa047270.36966319
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36336840
98Morphine addiction_Homo sapiens_hsa050320.36181626
99Chemical carcinogenesis_Homo sapiens_hsa052040.33712836
100Hematopoietic cell lineage_Homo sapiens_hsa046400.33399508

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