ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	gamma-aminobutyric acid transport (GO:0015812)	6.18322179
2	copper ion homeostasis (GO:0055070)	5.09897795
3	DNA deamination (GO:0045006)	4.12842765
4	regulation of meiosis I (GO:0060631)	4.07835543
5	sodium-independent organic anion transport (GO:0043252)	4.06246237
6	cellular hyperosmotic response (GO:0071474)	3.95706425
7	regulation of regulatory T cell differentiation (GO:0045589)	3.93627212
8	water-soluble vitamin biosynthetic process (GO:0042364)	3.90945193
9	protein-cofactor linkage (GO:0018065)	3.88401446
10	cullin deneddylation (GO:0010388)	3.68311469
11	organic cation transport (GO:0015695)	3.63874812
12	proteasome assembly (GO:0043248)	3.59378631
13	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.52506904
14	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.52506904
15	adenosine metabolic process (GO:0046085)	3.48290517
16	T-helper cell differentiation (GO:0042093)	3.46890162
17	CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)	3.46890162
18	respiratory chain complex IV assembly (GO:0008535)	3.46671736
19	negative regulation of thymocyte apoptotic process (GO:0070244)	3.46526660
20	sleep (GO:0030431)	3.44092594
21	synapsis (GO:0007129)	3.40179948
22	signal peptide processing (GO:0006465)	3.38267284
23	preassembly of GPI anchor in ER membrane (GO:0016254)	3.35638851
24	mitochondrial respiratory chain complex assembly (GO:0033108)	3.33027928
25	protein complex biogenesis (GO:0070271)	3.31568369
26	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.26660945
27	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.26660945
28	isotype switching (GO:0045190)	3.26660945
29	peptidyl-histidine modification (GO:0018202)	3.20280406
30	response to gravity (GO:0009629)	3.19617909
31	alpha-beta T cell differentiation involved in immune response (GO:0002293)	3.15416419
32	alpha-beta T cell activation involved in immune response (GO:0002287)	3.15416419
33	T cell differentiation involved in immune response (GO:0002292)	3.15416419
34	cytochrome complex assembly (GO:0017004)	3.08804772
35	amino acid activation (GO:0043038)	3.07291955
36	tRNA aminoacylation (GO:0043039)	3.07291955
37	termination of RNA polymerase III transcription (GO:0006386)	3.06986898
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.06986898
39	tolerance induction (GO:0002507)	3.06935619
40	tRNA aminoacylation for protein translation (GO:0006418)	3.06589785
41	protein deneddylation (GO:0000338)	3.06574916
42	germ cell migration (GO:0008354)	3.04944206
43	cytokine biosynthetic process (GO:0042089)	3.03985038
44	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.03595670
45	negative regulation of hormone biosynthetic process (GO:0032353)	3.03062417
46	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.02449367
47	NADH dehydrogenase complex assembly (GO:0010257)	3.02449367
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.02449367
49	kynurenine metabolic process (GO:0070189)	3.00904656
50	negative regulation of meiosis (GO:0045835)	3.00720384
51	branched-chain amino acid catabolic process (GO:0009083)	2.99724202
52	intracellular protein transmembrane import (GO:0044743)	2.99161659
53	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.95077012
54	negative regulation of meiotic cell cycle (GO:0051447)	2.94708471
55	somatic diversification of immunoglobulins (GO:0016445)	2.93289077
56	endocardial cushion morphogenesis (GO:0003203)	2.86538156
57	piRNA metabolic process (GO:0034587)	2.83582668
58	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.83511248
59	rRNA catabolic process (GO:0016075)	2.81972235
60	regulation of memory T cell differentiation (GO:0043380)	2.81439531
61	folic acid-containing compound biosynthetic process (GO:0009396)	2.81046215
62	tryptophan catabolic process (GO:0006569)	2.81044862
63	indole-containing compound catabolic process (GO:0042436)	2.81044862
64	indolalkylamine catabolic process (GO:0046218)	2.81044862
65	DNA double-strand break processing (GO:0000729)	2.77056118
66	tRNA metabolic process (GO:0006399)	2.76413550
67	rRNA modification (GO:0000154)	2.74990787
68	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.72802429
69	negative regulation of hormone metabolic process (GO:0032351)	2.72083795
70	double-strand break repair via homologous recombination (GO:0000724)	2.69454926
71	tRNA processing (GO:0008033)	2.67662355
72	maturation of SSU-rRNA (GO:0030490)	2.66301094
73	cytokine metabolic process (GO:0042107)	2.65522262
74	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.65408655
75	iron ion import (GO:0097286)	2.64539737
76	recombinational repair (GO:0000725)	2.64035753
77	pteridine-containing compound biosynthetic process (GO:0042559)	2.63856500
78	regulation of cellular amino acid metabolic process (GO:0006521)	2.62529859
79	platelet dense granule organization (GO:0060155)	2.61276648
80	alpha-beta T cell activation (GO:0046631)	2.58657650
81	cellular response to dsRNA (GO:0071359)	2.57280385
82	mitotic cell cycle arrest (GO:0071850)	2.55520004
83	regulation of immunoglobulin secretion (GO:0051023)	2.54392993
84	alpha-beta T cell differentiation (GO:0046632)	2.54126023
85	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.53896336
86	inositol phosphate dephosphorylation (GO:0046855)	2.52622849
87	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.52622849
88	aerobic respiration (GO:0009060)	2.51939847
89	maturation of 5.8S rRNA (GO:0000460)	2.51918315
90	regulation of histone phosphorylation (GO:0033127)	2.51847718
91	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.50841274
92	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.50841274
93	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.50841274
94	positive regulation of male gonad development (GO:2000020)	2.50596704
95	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.50064123
96	positive regulation of histone H3-K4 methylation (GO:0051571)	2.50049436
97	fatty acid elongation (GO:0030497)	2.49409596
98	rRNA processing (GO:0006364)	2.48721129
99	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.48247343
100	regulation of protein polyubiquitination (GO:1902914)	10.3761846

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.17987957
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.43099834
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.56856462
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	3.38329146
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.07719379
6	VDR_22108803_ChIP-Seq_LS180_Human	2.70998229
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.66504120
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.55736494
9	VDR_23849224_ChIP-Seq_CD4+_Human	2.55398746
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.52283807
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.36436126
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.29982087
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.25382279
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.22447334
15	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.22446138
16	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.22446138
17	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.22446138
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.21497972
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.14164205
20	ZNF274_21170338_ChIP-Seq_K562_Hela	2.09570445
21	TAF15_26573619_Chip-Seq_HEK293_Human	2.02694239
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.94618055
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.79415984
24	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.79393547
25	E2F7_22180533_ChIP-Seq_HELA_Human	1.79001268
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.71727162
27	MYC_18940864_ChIP-ChIP_HL60_Human	1.70644584
28	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.58014793
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.54884297
30	P300_19829295_ChIP-Seq_ESCs_Human	1.53046541
31	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.49997060
32	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48558668
33	EWS_26573619_Chip-Seq_HEK293_Human	1.46865589
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.44970836
35	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.43198642
36	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42379383
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.39488702
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39252089
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39252089
40	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39197568
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37502524
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.35602650
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.33249202
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33065379
45	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.32385237
46	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27719910
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27068720
48	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25889887
49	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.25625820
50	GATA1_22025678_ChIP-Seq_K562_Human	1.24631913
51	CBP_20019798_ChIP-Seq_JUKART_Human	1.21691050
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21691050
53	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.20480658
54	GATA3_26560356_Chip-Seq_TH2_Human	1.14361467
55	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.13670120
56	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11077280
57	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11077280
58	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.10368999
59	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09835755
60	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.08405578
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.05422812
62	CDX2_22108803_ChIP-Seq_LS180_Human	1.04409163
63	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04272381
64	GATA3_26560356_Chip-Seq_TH1_Human	1.04140242
65	DCP1A_22483619_ChIP-Seq_HELA_Human	1.03535596
66	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.03247777
67	AR_20517297_ChIP-Seq_VCAP_Human	1.02975635
68	RUNX_20019798_ChIP-Seq_JUKART_Human	1.02409896
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.02053624
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00867220
71	MYB_26560356_Chip-Seq_TH2_Human	1.00184947
72	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99528385
73	NCOR_22424771_ChIP-Seq_293T_Human	0.99334224
74	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99119943
75	TTF2_22483619_ChIP-Seq_HELA_Human	0.98704722
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97447066
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.95101069
78	IGF1R_20145208_ChIP-Seq_DFB_Human	0.94697090
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93691918
80	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.93385463
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93066977
82	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.92766612
83	FUS_26573619_Chip-Seq_HEK293_Human	0.92716161
84	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.91128956
85	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.91020099
86	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.91007647
87	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.90941070
88	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.90750525
89	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.89242535
90	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88505350
91	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.88345935
92	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.87431320
93	ERG_20517297_ChIP-Seq_VCAP_Human	0.86345131
94	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.85760627
95	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.85109485
96	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.83841821
97	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.83790685
98	P53_22387025_ChIP-Seq_ESCs_Mouse	0.83747160
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.83513905
100	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.82609501

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.94151945
2	MP0004147_increased_porphyrin_level	4.98641027
3	MP0002102_abnormal_ear_morphology	3.22261855
4	MP0002009_preneoplasia	3.13811599
5	MP0003195_calcinosis	2.48251958
6	MP0002166_altered_tumor_susceptibility	2.43854176
7	MP0002138_abnormal_hepatobiliary_system	2.38674714
8	MP0008057_abnormal_DNA_replication	2.36254754
9	MP0005645_abnormal_hypothalamus_physiol	2.32018741
10	MP0005671_abnormal_response_to	2.31022363
11	MP0006072_abnormal_retinal_apoptosis	2.26301510
12	MP0010386_abnormal_urinary_bladder	2.13687684
13	MP0003283_abnormal_digestive_organ	2.11459908
14	MP0003011_delayed_dark_adaptation	2.09514489
15	MP0003183_abnormal_peptide_metabolism	2.00147718
16	MP0002163_abnormal_gland_morphology	1.99335030
17	MP0003763_abnormal_thymus_physiology	1.98407408
18	MP0002006_tumorigenesis	1.92153456
19	MP0002277_abnormal_respiratory_mucosa	1.79930941
20	MP0003950_abnormal_plasma_membrane	1.77954377
21	MP0001881_abnormal_mammary_gland	1.77223159
22	MP0005084_abnormal_gallbladder_morpholo	1.75269342
23	MP0003656_abnormal_erythrocyte_physiolo	1.68420866
24	MP0003718_maternal_effect	1.66862358
25	MP0005379_endocrine/exocrine_gland_phen	1.64236465
26	MP0005551_abnormal_eye_electrophysiolog	1.61742792
27	MP0009780_abnormal_chondrocyte_physiolo	1.60163769
28	MP0001835_abnormal_antigen_presentation	1.58935107
29	MP0001986_abnormal_taste_sensitivity	1.57740330
30	MP0005075_abnormal_melanosome_morpholog	1.57282788
31	MP0004043_abnormal_pH_regulation	1.53703535
32	MP0005253_abnormal_eye_physiology	1.50534618
33	MP0008872_abnormal_physiological_respon	1.48779986
34	MP0003045_fibrosis	1.44138685
35	MP0005167_abnormal_blood-brain_barrier	1.44038899
36	MP0003936_abnormal_reproductive_system	1.43187987
37	MP0002160_abnormal_reproductive_system	1.37389123
38	MP0002148_abnormal_hypersensitivity_rea	1.36459555
39	MP0003943_abnormal_hepatobiliary_system	1.36272478
40	MP0003693_abnormal_embryo_hatching	1.36265748
41	MP0008058_abnormal_DNA_repair	1.35647687
42	MP0005646_abnormal_pituitary_gland	1.33550490
43	MP0002254_reproductive_system_inflammat	1.33162682
44	MP0005174_abnormal_tail_pigmentation	1.28409803
45	MP0000685_abnormal_immune_system	1.23453522
46	MP0001501_abnormal_sleep_pattern	1.21944803
47	MP0001800_abnormal_humoral_immune	1.21710777
48	MP0003646_muscle_fatigue	1.21008510
49	MP0000465_gastrointestinal_hemorrhage	1.18693506
50	MP0005085_abnormal_gallbladder_physiolo	1.17901461
51	MP0004885_abnormal_endolymph	1.15267403
52	MP0010094_abnormal_chromosome_stability	1.14932091
53	MP0001873_stomach_inflammation	1.08748860
54	MP0008875_abnormal_xenobiotic_pharmacok	1.08292397
55	MP0000627_abnormal_mammary_gland	1.05913077
56	MP0000538_abnormal_urinary_bladder	1.04380697
57	MP0001790_abnormal_immune_system	1.04120706
58	MP0005387_immune_system_phenotype	1.04120706
59	MP0008007_abnormal_cellular_replicative	1.03386407
60	MP0001485_abnormal_pinna_reflex	1.03349727
61	MP0006036_abnormal_mitochondrial_physio	1.01934033
62	MP0003638_abnormal_response/metabolism_	1.00025109
63	MP0001764_abnormal_homeostasis	1.00020936
64	MP0000383_abnormal_hair_follicle	0.98485433
65	MP0002638_abnormal_pupillary_reflex	0.95982093
66	MP0004782_abnormal_surfactant_physiolog	0.95942809
67	MP0005365_abnormal_bile_salt	0.94599673
68	MP0004142_abnormal_muscle_tone	0.93025101
69	MP0000462_abnormal_digestive_system	0.87474240
70	MP0002723_abnormal_immune_serum	0.87286499
71	MP0003866_abnormal_defecation	0.87115175
72	MP0005636_abnormal_mineral_homeostasis	0.85251419
73	MP0002876_abnormal_thyroid_physiology	0.84243085
74	MP0002938_white_spotting	0.83719724
75	MP0000703_abnormal_thymus_morphology	0.83698765
76	MP0000689_abnormal_spleen_morphology	0.81596055
77	MP0005000_abnormal_immune_tolerance	0.81204223
78	MP0003252_abnormal_bile_duct	0.81170791
79	MP0005389_reproductive_system_phenotype	0.80775452
80	MP0001929_abnormal_gametogenesis	0.80736477
81	MP0001145_abnormal_male_reproductive	0.80340513
82	MP0003787_abnormal_imprinting	0.79137320
83	MP0001119_abnormal_female_reproductive	0.78671124
84	MP0002693_abnormal_pancreas_physiology	0.76245529
85	MP0006035_abnormal_mitochondrial_morpho	0.76061718
86	MP0000631_abnormal_neuroendocrine_gland	0.75899429
87	MP0009643_abnormal_urine_homeostasis	0.74244800
88	MP0002210_abnormal_sex_determination	0.74041594
89	MP0005310_abnormal_salivary_gland	0.72304221
90	MP0000653_abnormal_sex_gland	0.71407554
91	MP0005410_abnormal_fertilization	0.70920830
92	MP0005395_other_phenotype	0.70594540
93	MP0002933_joint_inflammation	0.70282529
94	MP0002928_abnormal_bile_duct	0.68667002
95	MP0003724_increased_susceptibility_to	0.66202949
96	MP0002722_abnormal_immune_system	0.64259155
97	MP0004145_abnormal_muscle_electrophysio	0.62881161
98	MP0002398_abnormal_bone_marrow	0.61376198
99	MP0001765_abnormal_ion_homeostasis	0.60468182
100	MP0001905_abnormal_dopamine_level	0.60370154

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Large for gestational age (HP:0001520)	4.72442980
2	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.60365744
3	Abnormality of alanine metabolism (HP:0010916)	4.60365744
4	Hyperalaninemia (HP:0003348)	4.60365744
5	Increased hepatocellular lipid droplets (HP:0006565)	4.09268804
6	Lipid accumulation in hepatocytes (HP:0006561)	4.05641277
7	Neuroendocrine neoplasm (HP:0100634)	4.04667044
8	Duplicated collecting system (HP:0000081)	3.58895230
9	Pheochromocytoma (HP:0002666)	3.36073410
10	Abnormality of the renal collecting system (HP:0004742)	3.25262319
11	Increased serum ferritin (HP:0003281)	3.07368088
12	Conjunctival hamartoma (HP:0100780)	3.01960835
13	Renal Fanconi syndrome (HP:0001994)	2.99631473
14	Ketoacidosis (HP:0001993)	2.86602567
15	Neoplasm of the adrenal gland (HP:0100631)	2.85801475
16	Stomatitis (HP:0010280)	2.80560727
17	Abnormality of the common coagulation pathway (HP:0010990)	2.79158236
18	Abnormality of macrophages (HP:0004311)	2.65717773
19	Abnormality of transition element cation homeostasis (HP:0011030)	2.58013367
20	Exertional dyspnea (HP:0002875)	2.55776363
21	Hamartoma of the eye (HP:0010568)	2.52423126
22	Congenital, generalized hypertrichosis (HP:0004540)	2.52232125
23	Abnormality of the labia minora (HP:0012880)	2.51795246
24	Bone cyst (HP:0012062)	2.51233010
25	Hypomagnesemia (HP:0002917)	2.49321044
26	Stomach cancer (HP:0012126)	2.47894825
27	Increased serum lactate (HP:0002151)	2.47726338
28	IgG deficiency (HP:0004315)	2.46767026
29	Hypoglycemic seizures (HP:0002173)	2.46123294
30	Abnormality of iron homeostasis (HP:0011031)	2.45562152
31	Opisthotonus (HP:0002179)	2.44760360
32	Increased CSF lactate (HP:0002490)	2.43953216
33	Neoplasm of the peripheral nervous system (HP:0100007)	2.43694182
34	Shoulder girdle muscle weakness (HP:0003547)	2.38097913
35	Abnormality of the pons (HP:0007361)	2.37239506
36	Type II lissencephaly (HP:0007260)	2.35287400
37	Glycosuria (HP:0003076)	2.30226951
38	Abnormality of urine glucose concentration (HP:0011016)	2.30226951
39	Hemiparesis (HP:0001269)	2.30035230
40	Meningioma (HP:0002858)	2.29392295
41	Respiratory difficulties (HP:0002880)	2.28922916
42	Pancreatic islet-cell hyperplasia (HP:0004510)	2.22637677
43	Cerebral hypomyelination (HP:0006808)	2.22382121
44	Prostate neoplasm (HP:0100787)	2.21784083
45	Mitochondrial inheritance (HP:0001427)	2.20511023
46	Increased intramyocellular lipid droplets (HP:0012240)	2.19177934
47	Goiter (HP:0000853)	2.17214450
48	Cellular immunodeficiency (HP:0005374)	2.15460100
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.14832498
50	Angiofibromas (HP:0010615)	2.13349901
51	Adenoma sebaceum (HP:0009720)	2.13349901
52	Hypoglycemic coma (HP:0001325)	2.11232190
53	Papillary thyroid carcinoma (HP:0002895)	2.07797240
54	Abnormal drinking behavior (HP:0030082)	2.07693915
55	Polydipsia (HP:0001959)	2.07693915
56	Scotoma (HP:0000575)	2.06321046
57	Pancreatic cysts (HP:0001737)	2.06225191
58	Hyperinsulinemic hypoglycemia (HP:0000825)	2.03399317
59	Abnormality of the renal medulla (HP:0100957)	2.01636916
60	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.00138495
61	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.00138495
62	Colon cancer (HP:0003003)	2.00103535
63	Hepatitis (HP:0012115)	1.99212198
64	Nephronophthisis (HP:0000090)	1.98827131
65	Abnormality of the renal cortex (HP:0011035)	1.97518451
66	Congenital stationary night blindness (HP:0007642)	1.96928346
67	Cerebellar dysplasia (HP:0007033)	1.96210798
68	Abnormality of magnesium homeostasis (HP:0004921)	1.92906527
69	Increased muscle lipid content (HP:0009058)	1.92835371
70	Progressive microcephaly (HP:0000253)	1.92751194
71	Ureteral duplication (HP:0000073)	1.92340489
72	Abnormality of the pancreatic islet cells (HP:0006476)	1.91934034
73	Abnormality of endocrine pancreas physiology (HP:0012093)	1.91934034
74	Progressive inability to walk (HP:0002505)	1.89739873
75	Breast carcinoma (HP:0003002)	1.89682444
76	Hyperglycemia (HP:0003074)	1.88933604
77	Methylmalonic acidemia (HP:0002912)	1.88309713
78	Lactic acidosis (HP:0003128)	1.87820140
79	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.87658112
80	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.87097772
81	Hyperphosphaturia (HP:0003109)	1.86180286
82	Hypokalemic alkalosis (HP:0001949)	1.84777534
83	Glioma (HP:0009733)	1.84360346
84	Ependymoma (HP:0002888)	1.84202826
85	Neoplasm of the rectum (HP:0100743)	1.82488223
86	Abnormality of serum amino acid levels (HP:0003112)	1.81935625
87	Rimmed vacuoles (HP:0003805)	1.81777952
88	Alkalosis (HP:0001948)	1.81397101
89	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.80789921
90	Decreased circulating renin level (HP:0003351)	1.79446723
91	Acute necrotizing encephalopathy (HP:0006965)	1.78916233
92	Abnormality of renal resorption (HP:0011038)	1.78808573
93	Pelvic girdle muscle weakness (HP:0003749)	1.76688058
94	Thyroid carcinoma (HP:0002890)	1.76192973
95	Lethargy (HP:0001254)	1.75446826
96	Abnormality of the vocal cords (HP:0008777)	1.75445672
97	Large hands (HP:0001176)	1.75372761
98	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.75241223
99	Tetany (HP:0001281)	1.74662752
100	Absent thumb (HP:0009777)	1.74319764

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.51022848
2	ZAK	3.19138651
3	VRK2	3.12952480
4	MAPKAPK3	3.04032860
5	PASK	3.03252741
6	TAF1	2.85037761
7	EIF2AK1	2.55825346
8	FRK	2.55684256
9	BUB1	2.23176872
10	WNK4	2.07272305
11	TLK1	1.86658968
12	TRIM28	1.84166087
13	NUAK1	1.77396381
14	CCNB1	1.75400202
15	IKBKB	1.69708247
16	STK39	1.69197403
17	TEC	1.69094196
18	MAPKAPK5	1.67219692
19	PLK3	1.65830165
20	EIF2AK3	1.62167957
21	TNIK	1.61485994
22	MKNK1	1.60371823
23	MAP2K2	1.60328966
24	KIT	1.53236005
25	AKT2	1.52907402
26	OXSR1	1.51920914
27	MST4	1.50339399
28	NEK1	1.46974658
29	STK38L	1.46226334
30	PDK2	1.40203168
31	TXK	1.34385749
32	ADRBK2	1.34052387
33	VRK1	1.32095752
34	ITK	1.26405733
35	DAPK1	1.23803275
36	WNK3	1.22907833
37	MKNK2	1.15062374
38	TAOK3	1.14841133
39	BCKDK	1.10585343
40	STK24	1.09243885
41	FGR	1.05287964
42	SMG1	1.04067339
43	GRK1	0.90167802
44	PBK	0.88048345
45	MUSK	0.87591765
46	PAK3	0.86674443
47	RPS6KB2	0.86217871
48	PINK1	0.83999407
49	MAP2K6	0.80182600
50	MAP3K12	0.80180512
51	FLT3	0.78996383
52	BMPR1B	0.74199415
53	PIK3CG	0.69231836
54	CSF1R	0.67825800
55	NLK	0.64428226
56	IRAK1	0.63264293
57	TNK2	0.63240637
58	CDK8	0.62548313
59	ALK	0.61092624
60	INSRR	0.60402294
61	EIF2AK2	0.60087193
62	STK16	0.58433181
63	FES	0.58060815
64	PLK2	0.58015305
65	YES1	0.57348740
66	BTK	0.56355342
67	STK3	0.54785739
68	TESK2	0.51857945
69	IKBKE	0.50125220
70	TRPM7	0.47701391
71	SIK3	0.47472060
72	MARK3	0.47202392
73	CAMKK2	0.46731744
74	MATK	0.46702634
75	LCK	0.44435133
76	BMPR2	0.44244713
77	CAMKK1	0.44224022
78	MAPK11	0.42784045
79	RPS6KA6	0.42054677
80	MAP3K14	0.41223157
81	PNCK	0.40791730
82	SYK	0.40361294
83	MAPK4	0.40030542
84	MAP4K1	0.39459816
85	MAPK7	0.39250909
86	RPS6KA2	0.38382182
87	MAPK13	0.38082010
88	ADRBK1	0.37804346
89	PRKCE	0.37117851
90	TGFBR1	0.36051837
91	RPS6KC1	0.34898182
92	RPS6KL1	0.34898182
93	LYN	0.34609901
94	CSNK2A1	0.33270266
95	STK11	0.33211687
96	CLK1	0.33015347
97	INSR	0.32866964
98	GRK6	0.31794713
99	CSNK2A2	0.31058668
100	PLK4	0.30440613

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.70105439
2	Protein export_Homo sapiens_hsa03060	3.05005117
3	RNA polymerase_Homo sapiens_hsa03020	2.98939125
4	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.91574797
5	Fatty acid elongation_Homo sapiens_hsa00062	2.89453548
6	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.78397485
7	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.65790286
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.51342532
9	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.49446462
10	Caffeine metabolism_Homo sapiens_hsa00232	2.48861852
11	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.33392448
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.25166468
13	Phototransduction_Homo sapiens_hsa04744	2.25003608
14	One carbon pool by folate_Homo sapiens_hsa00670	2.17878371
15	Basal transcription factors_Homo sapiens_hsa03022	2.10472613
16	Homologous recombination_Homo sapiens_hsa03440	2.08726488
17	Mismatch repair_Homo sapiens_hsa03430	1.85155856
18	Sulfur relay system_Homo sapiens_hsa04122	1.84900241
19	RNA degradation_Homo sapiens_hsa03018	1.72769365
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68930074
21	Propanoate metabolism_Homo sapiens_hsa00640	1.68323685
22	Ribosome_Homo sapiens_hsa03010	1.67267487
23	RNA transport_Homo sapiens_hsa03013	1.64890789
24	Purine metabolism_Homo sapiens_hsa00230	1.59814870
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.58062875
26	Primary immunodeficiency_Homo sapiens_hsa05340	1.57356997
27	Oxidative phosphorylation_Homo sapiens_hsa00190	1.53865110
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.42643949
29	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.38190120
30	DNA replication_Homo sapiens_hsa03030	1.31023708
31	Parkinsons disease_Homo sapiens_hsa05012	1.30608505
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.21686356
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.13842243
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.11419276
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.10620140
36	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.06048578
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.04825327
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.02818360
39	Nucleotide excision repair_Homo sapiens_hsa03420	1.02514849
40	Folate biosynthesis_Homo sapiens_hsa00790	0.99457060
41	Fatty acid metabolism_Homo sapiens_hsa01212	0.99312535
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.98988789
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98971914
44	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.98541629
45	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96317152
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.89329893
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.88484359
48	Huntingtons disease_Homo sapiens_hsa05016	0.83332304
49	Pyruvate metabolism_Homo sapiens_hsa00620	0.82272739
50	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.80665963
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.80099071
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75128877
53	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.75018968
54	Butanoate metabolism_Homo sapiens_hsa00650	0.71575108
55	Peroxisome_Homo sapiens_hsa04146	0.71348275
56	Legionellosis_Homo sapiens_hsa05134	0.65917205
57	ABC transporters_Homo sapiens_hsa02010	0.64078219
58	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63151266
59	Spliceosome_Homo sapiens_hsa03040	0.62483502
60	Type I diabetes mellitus_Homo sapiens_hsa04940	0.62421217
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62299509
62	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.62121157
63	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.61021401
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59610651
65	Regulation of autophagy_Homo sapiens_hsa04140	0.59369285
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.58857581
67	Metabolic pathways_Homo sapiens_hsa01100	0.56984866
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55089418
69	Base excision repair_Homo sapiens_hsa03410	0.54395910
70	Mineral absorption_Homo sapiens_hsa04978	0.54296873
71	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.51543444
72	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50198887
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.49546515
74	Retinol metabolism_Homo sapiens_hsa00830	0.48845591
75	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.48666816
76	Collecting duct acid secretion_Homo sapiens_hsa04966	0.48057945
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47828891
78	Alzheimers disease_Homo sapiens_hsa05010	0.47344141
79	Olfactory transduction_Homo sapiens_hsa04740	0.47027708
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.46887950
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.46706240
82	mRNA surveillance pathway_Homo sapiens_hsa03015	0.44318475
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.43237908
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.41996922
85	Small cell lung cancer_Homo sapiens_hsa05222	0.40998565
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.40397815
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39499439
88	Measles_Homo sapiens_hsa05162	0.37248233
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.37154156
90	Circadian rhythm_Homo sapiens_hsa04710	0.33099615
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.32499584
92	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.32265847
93	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.31922910
94	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31075822
95	Fatty acid degradation_Homo sapiens_hsa00071	0.31013464
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.30505640
97	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.30098179
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28695272
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.27566556
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.24040603

PAICSP5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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