PAICSP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male sex determination (GO:0030238)8.41121271
2behavioral response to nicotine (GO:0035095)5.99497652
3negative regulation of leukocyte chemotaxis (GO:0002689)5.86066041
4myotube differentiation (GO:0014902)5.16832315
5alanine transport (GO:0032328)5.12852580
6regulation of cilium movement (GO:0003352)4.87234173
7nitric oxide biosynthetic process (GO:0006809)4.79491116
8presynaptic membrane assembly (GO:0097105)4.78620556
9folic acid transport (GO:0015884)4.76734278
10sex determination (GO:0007530)4.59748134
11positive regulation of growth hormone secretion (GO:0060124)4.37759369
12proline transport (GO:0015824)4.35742114
13postsynaptic membrane organization (GO:0001941)4.28385283
14histone-serine phosphorylation (GO:0035404)4.05674599
15regulation of type B pancreatic cell apoptotic process (GO:2000674)3.85599256
16positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)3.85584319
17nitric oxide mediated signal transduction (GO:0007263)3.85088666
18folic acid metabolic process (GO:0046655)3.83912127
19inner ear receptor cell differentiation (GO:0060113)3.81141055
20cellular ketone body metabolic process (GO:0046950)3.81091303
21positive regulation of CREB transcription factor activity (GO:0032793)3.78611035
22heme transport (GO:0015886)3.77651395
23glycine transport (GO:0015816)3.74280063
24presynaptic membrane organization (GO:0097090)3.73716711
25regulation of histone phosphorylation (GO:0033127)3.69973494
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.61908725
27somite rostral/caudal axis specification (GO:0032525)3.61668052
28retinal rod cell development (GO:0046548)3.60828366
29behavioral response to ethanol (GO:0048149)3.55179574
30regulation of hexokinase activity (GO:1903299)3.54433275
31regulation of glucokinase activity (GO:0033131)3.54433275
32arginine metabolic process (GO:0006525)3.51794120
33negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.49910053
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.43635653
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43635653
36GTP biosynthetic process (GO:0006183)3.40413498
37keratinocyte development (GO:0003334)3.39702718
38dopamine biosynthetic process (GO:0042416)3.39040692
39positive regulation of heart rate (GO:0010460)3.35925737
40regulation of microtubule-based movement (GO:0060632)3.35578522
41ketone body metabolic process (GO:1902224)3.35523326
42regulation of interleukin-8 secretion (GO:2000482)3.32437923
43ovulation from ovarian follicle (GO:0001542)3.29567485
44arginine catabolic process (GO:0006527)3.21764725
45kynurenine metabolic process (GO:0070189)3.20451300
46positive regulation of guanylate cyclase activity (GO:0031284)3.19800011
47positive regulation of gastrulation (GO:2000543)3.16760628
48dorsal/ventral neural tube patterning (GO:0021904)3.14883792
49negative regulation of telomere maintenance (GO:0032205)3.14563857
50UTP biosynthetic process (GO:0006228)3.12080051
51endocrine pancreas development (GO:0031018)3.08790547
52negative regulation of translation, ncRNA-mediated (GO:0040033)3.08456539
53regulation of translation, ncRNA-mediated (GO:0045974)3.08456539
54negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.08456539
55ubiquinone biosynthetic process (GO:0006744)3.07880574
56detection of bacterium (GO:0016045)3.06982753
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06152424
58indole-containing compound catabolic process (GO:0042436)3.05788298
59indolalkylamine catabolic process (GO:0046218)3.05788298
60tryptophan catabolic process (GO:0006569)3.05788298
61Leydig cell differentiation (GO:0033327)3.05300931
62ubiquinone metabolic process (GO:0006743)3.05285700
63nitric oxide metabolic process (GO:0046209)3.05134422
64platelet dense granule organization (GO:0060155)3.04975064
65neuronal action potential (GO:0019228)3.01685723
66microtubule severing (GO:0051013)3.00415195
67cartilage condensation (GO:0001502)2.98714366
68cell aggregation (GO:0098743)2.98714366
69negative regulation of adenylate cyclase activity (GO:0007194)2.95669932
70interleukin-1-mediated signaling pathway (GO:0070498)2.91671330
71negative regulation of lyase activity (GO:0051350)2.91386133
72nonmotile primary cilium assembly (GO:0035058)2.86866358
73positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.86033085
74regulation of guanylate cyclase activity (GO:0031282)2.85319776
75artery smooth muscle contraction (GO:0014824)2.81443117
76signal transduction involved in regulation of gene expression (GO:0023019)2.80944983
77mechanoreceptor differentiation (GO:0042490)2.80610894
78UTP metabolic process (GO:0046051)2.80334328
79negative regulation of cyclase activity (GO:0031280)2.79435234
80negative regulation of interleukin-1 beta production (GO:0032691)2.78607479
81prepulse inhibition (GO:0060134)2.77159599
82startle response (GO:0001964)2.75278550
83regulation of growth hormone secretion (GO:0060123)2.73776210
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73305180
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72578331
86mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.68503035
87negative regulation of interleukin-1 production (GO:0032692)2.67146906
88iron coordination entity transport (GO:1901678)2.65591858
89purinergic nucleotide receptor signaling pathway (GO:0035590)2.65302888
90detection of other organism (GO:0098543)2.65272171
91growth hormone secretion (GO:0030252)2.64840488
92regulation of respiratory system process (GO:0044065)2.64037660
93pattern specification involved in kidney development (GO:0061004)2.60608110
94intracellular protein transmembrane import (GO:0044743)2.60199157
95vitamin transport (GO:0051180)2.59869040
96aldehyde catabolic process (GO:0046185)2.59365598
97retinal metabolic process (GO:0042574)2.58296993
98righting reflex (GO:0060013)2.57686245
99multicellular organism reproduction (GO:0032504)2.57574159
100quinone biosynthetic process (GO:1901663)2.57393275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.79259495
2EZH2_22144423_ChIP-Seq_EOC_Human3.78720205
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99453784
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68275952
5CBX2_27304074_Chip-Seq_ESCs_Mouse2.66897689
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62834851
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52846248
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.48381366
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.41779864
10FUS_26573619_Chip-Seq_HEK293_Human2.36725636
11GATA1_22025678_ChIP-Seq_K562_Human2.30662854
12GBX2_23144817_ChIP-Seq_PC3_Human2.30365321
13VDR_22108803_ChIP-Seq_LS180_Human2.28523926
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19963404
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.16715302
16P300_19829295_ChIP-Seq_ESCs_Human2.12263257
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.08103082
18TP53_16413492_ChIP-PET_HCT116_Human2.01796670
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00155083
20CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89517482
21TAF15_26573619_Chip-Seq_HEK293_Human1.86710943
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.82896823
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.80964004
24ER_23166858_ChIP-Seq_MCF-7_Human1.80351586
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79143934
26EWS_26573619_Chip-Seq_HEK293_Human1.74906993
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.72706953
28BCAT_22108803_ChIP-Seq_LS180_Human1.71781381
29DROSHA_22980978_ChIP-Seq_HELA_Human1.69295431
30IRF1_19129219_ChIP-ChIP_H3396_Human1.66289917
31STAT3_23295773_ChIP-Seq_U87_Human1.62603327
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60851215
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58651002
34TCF4_22108803_ChIP-Seq_LS180_Human1.58551655
35AR_25329375_ChIP-Seq_VCAP_Human1.57347436
36REST_21632747_ChIP-Seq_MESCs_Mouse1.55802983
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54709481
38SMAD4_21799915_ChIP-Seq_A2780_Human1.54689607
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54325636
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48464980
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46633761
42TDRD3_21172665_ChIP-Seq_MCF-7_Human1.46472949
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41889019
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.40686170
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40232011
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.37525619
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36924592
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.36715184
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36485552
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35767365
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.33985183
52FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33985183
53RNF2_27304074_Chip-Seq_NSC_Mouse1.33934800
54TCF4_23295773_ChIP-Seq_U87_Human1.33710629
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33525047
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32142500
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.30078970
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26285350
59TP53_22573176_ChIP-Seq_HFKS_Human1.26217450
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24536137
61CBP_20019798_ChIP-Seq_JUKART_Human1.21890046
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21890046
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20491524
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18306313
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17565091
66HOXB7_26014856_ChIP-Seq_BT474_Human1.17250675
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16385643
68RUNX2_22187159_ChIP-Seq_PCA_Human1.15681848
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15472064
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15187946
71SMAD3_21741376_ChIP-Seq_ESCs_Human1.15079667
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15005810
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13890843
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.10558036
75WDR5_24793694_ChIP-Seq_LNCAP_Human1.10406999
76TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09971045
77SMRT_27268052_Chip-Seq_Bcells_Human1.06754767
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04618789
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.03833778
80RXR_22108803_ChIP-Seq_LS180_Human1.03697547
81CBP_21632823_ChIP-Seq_H3396_Human1.03360667
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02665853
83AR_20517297_ChIP-Seq_VCAP_Human1.01932699
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00821526
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00684020
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00309757
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99209326
88ERA_21632823_ChIP-Seq_H3396_Human0.98865494
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98490191
90SMAD4_21741376_ChIP-Seq_EPCs_Human0.98330136
91CDX2_22108803_ChIP-Seq_LS180_Human0.97678478
92GABP_17652178_ChIP-ChIP_JURKAT_Human0.96775640
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96050261
94TBL1_22424771_ChIP-Seq_293T_Human0.96010140
95TAF2_19829295_ChIP-Seq_ESCs_Human0.94601182
96OCT1_27270436_Chip-Seq_PROSTATE_Human0.93524186
97KDM2B_26808549_Chip-Seq_REH_Human0.93214862
98JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89299586
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89210653
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.87271481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.06069608
2MP0009780_abnormal_chondrocyte_physiolo3.93972355
3MP0000427_abnormal_hair_cycle3.78272125
4MP0003195_calcinosis3.31582063
5MP0000569_abnormal_digit_pigmentation3.09401488
6MP0002095_abnormal_skin_pigmentation2.73872287
7MP0003315_abnormal_perineum_morphology2.66182191
8MP0003283_abnormal_digestive_organ2.43451638
9MP0003045_fibrosis2.37362047
10MP0001968_abnormal_touch/_nociception2.36385817
11MP0004885_abnormal_endolymph2.34654898
12MP0005167_abnormal_blood-brain_barrier2.34517793
13MP0002277_abnormal_respiratory_mucosa2.34252398
14MP0008057_abnormal_DNA_replication2.31726328
15MP0002254_reproductive_system_inflammat2.30061913
16MP0003880_abnormal_central_pattern2.24967407
17MP0002938_white_spotting2.21571747
18MP0008877_abnormal_DNA_methylation2.03199975
19MP0003136_yellow_coat_color2.02442983
20MP0002876_abnormal_thyroid_physiology1.98886973
21MP0004043_abnormal_pH_regulation1.96035707
22MP0000383_abnormal_hair_follicle1.95457440
23MP0001485_abnormal_pinna_reflex1.86537600
24MP0000647_abnormal_sebaceous_gland1.83249917
25MP0001873_stomach_inflammation1.82713619
26MP0003959_abnormal_lean_body1.80742154
27MP0000516_abnormal_urinary_system1.78994964
28MP0005367_renal/urinary_system_phenotyp1.78994964
29MP0004142_abnormal_muscle_tone1.77116811
30MP0005551_abnormal_eye_electrophysiolog1.75871477
31MP0001764_abnormal_homeostasis1.52218938
32MP0005253_abnormal_eye_physiology1.51915597
33MP0005410_abnormal_fertilization1.49529853
34MP0003567_abnormal_fetal_cardiomyocyte1.47312827
35MP0001984_abnormal_olfaction1.44548854
36MP0006072_abnormal_retinal_apoptosis1.43770645
37MP0000015_abnormal_ear_pigmentation1.37513418
38MP0000631_abnormal_neuroendocrine_gland1.34577877
39MP0001501_abnormal_sleep_pattern1.33731965
40MP0000462_abnormal_digestive_system1.31059229
41MP0003941_abnormal_skin_development1.29721273
42MP0000579_abnormal_nail_morphology1.28855939
43MP0002064_seizures1.28433481
44MP0009046_muscle_twitch1.26467306
45MP0009697_abnormal_copulation1.25202399
46MP0005174_abnormal_tail_pigmentation1.24999153
47MP0004084_abnormal_cardiac_muscle1.23676336
48MP0002272_abnormal_nervous_system1.19733868
49MP0002234_abnormal_pharynx_morphology1.17610804
50MP0002098_abnormal_vibrissa_morphology1.17454053
51MP0005503_abnormal_tendon_morphology1.17080700
52MP0009745_abnormal_behavioral_response1.15827798
53MP0003787_abnormal_imprinting1.11682810
54MP0008007_abnormal_cellular_replicative1.06014242
55MP0004130_abnormal_muscle_cell1.04967292
56MP0002572_abnormal_emotion/affect_behav1.00842865
57MP0003632_abnormal_nervous_system0.99507203
58MP0000013_abnormal_adipose_tissue0.98209588
59MP0003937_abnormal_limbs/digits/tail_de0.97910574
60MP0003122_maternal_imprinting0.97786425
61MP0002139_abnormal_hepatobiliary_system0.94955405
62MP0002282_abnormal_trachea_morphology0.93043054
63MP0003638_abnormal_response/metabolism_0.90250191
64MP0003119_abnormal_digestive_system0.89286799
65MP0009384_cardiac_valve_regurgitation0.87130712
66MP0005332_abnormal_amino_acid0.85837156
67MP0004145_abnormal_muscle_electrophysio0.84319293
68MP0003890_abnormal_embryonic-extraembry0.83273921
69MP0002751_abnormal_autonomic_nervous0.83249164
70MP0002115_abnormal_skeleton_extremities0.83134491
71MP0002168_other_aberrant_phenotype0.82543038
72MP0006276_abnormal_autonomic_nervous0.79844340
73MP0010678_abnormal_skin_adnexa0.79501759
74MP0003646_muscle_fatigue0.79430210
75MP0002733_abnormal_thermal_nociception0.78996457
76MP0005376_homeostasis/metabolism_phenot0.77913940
77MP0005266_abnormal_metabolism0.77089921
78MP0002557_abnormal_social/conspecific_i0.77038924
79MP0002928_abnormal_bile_duct0.76705547
80MP0004215_abnormal_myocardial_fiber0.76169525
81MP0008872_abnormal_physiological_respon0.75671945
82MP0005646_abnormal_pituitary_gland0.73337075
83MP0001944_abnormal_pancreas_morphology0.73028807
84MP0002067_abnormal_sensory_capabilities0.72409018
85MP0002693_abnormal_pancreas_physiology0.72217695
86MP0005085_abnormal_gallbladder_physiolo0.71194170
87MP0008961_abnormal_basal_metabolism0.70384644
88MP0003137_abnormal_impulse_conducting0.68987244
89MP0005448_abnormal_energy_balance0.68124651
90MP0001905_abnormal_dopamine_level0.67809271
91MP0001986_abnormal_taste_sensitivity0.66881052
92MP0008775_abnormal_heart_ventricle0.65877880
93MP0004742_abnormal_vestibular_system0.65508830
94MP0000230_abnormal_systemic_arterial0.65068501
95MP0005381_digestive/alimentary_phenotyp0.64874899
96MP0004883_abnormal_blood_vessel0.64773390
97MP0005220_abnormal_exocrine_pancreas0.64610568
98MP0002909_abnormal_adrenal_gland0.64404792
99MP0002638_abnormal_pupillary_reflex0.64016722
100MP0002078_abnormal_glucose_homeostasis0.63631004

Predicted human phenotypes

RankGene SetZ-score
1Sex reversal (HP:0012245)4.87992777
2Abnormal sex determination (HP:0012244)4.87992777
3Hypoplasia of the uterus (HP:0000013)4.78840405
4Birth length less than 3rd percentile (HP:0003561)4.67612025
5Aplasia/hypoplasia of the uterus (HP:0008684)4.45608763
6Hyperglycinuria (HP:0003108)4.43626208
7Large for gestational age (HP:0001520)4.25570555
8Abnormality of alanine metabolism (HP:0010916)4.13461997
9Hyperalaninemia (HP:0003348)4.13461997
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.13461997
11Molar tooth sign on MRI (HP:0002419)4.01578283
12Abnormality of midbrain morphology (HP:0002418)4.01578283
13True hermaphroditism (HP:0010459)3.97805838
14Pancreatic fibrosis (HP:0100732)3.88797305
15Hypoplastic ischia (HP:0003175)3.88686434
16Pancreatic cysts (HP:0001737)3.82368514
17Increased circulating renin level (HP:0000848)3.70738445
18Abnormality of proline metabolism (HP:0010907)3.56890273
19Hydroxyprolinuria (HP:0003080)3.56890273
20Nephronophthisis (HP:0000090)3.49013375
21Abnormality of the ischium (HP:0003174)3.37022986
22Congenital, generalized hypertrichosis (HP:0004540)3.26502968
23Potter facies (HP:0002009)3.24232612
24Facial shape deformation (HP:0011334)3.24232612
25Furrowed tongue (HP:0000221)3.12710024
26Chronic hepatic failure (HP:0100626)3.07904808
27Broad metatarsal (HP:0001783)3.03861081
28Abnormality of glycine metabolism (HP:0010895)2.99525759
29Abnormality of serine family amino acid metabolism (HP:0010894)2.99525759
30Sclerocornea (HP:0000647)2.99325550
31Medial flaring of the eyebrow (HP:0010747)2.94276263
32Male pseudohermaphroditism (HP:0000037)2.92241980
33Abnormality of the renal medulla (HP:0100957)2.76474306
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.70585887
35Short hallux (HP:0010109)2.58902992
36Cystic liver disease (HP:0006706)2.55805020
37Abnormality of the pubic bones (HP:0003172)2.53358896
38Hypoplasia of the radius (HP:0002984)2.46754577
39Esophageal atresia (HP:0002032)2.46264847
40Megaloblastic anemia (HP:0001889)2.44711293
41Abnormality of renin-angiotensin system (HP:0000847)2.43486703
42Dyskinesia (HP:0100660)2.41178729
43Septo-optic dysplasia (HP:0100842)2.40787914
44Aplasia/Hypoplasia of the hallux (HP:0008362)2.38853047
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.37328946
46Congenital primary aphakia (HP:0007707)2.34221906
47Choroideremia (HP:0001139)2.32569558
48Gait imbalance (HP:0002141)2.29587390
49Gonadal dysgenesis (HP:0000133)2.28429466
50Anencephaly (HP:0002323)2.26227123
51Generalized hypopigmentation of hair (HP:0011358)2.25909156
52Absent thumb (HP:0009777)2.22697685
53Occipital encephalocele (HP:0002085)2.21538309
54Hyperventilation (HP:0002883)2.20519402
55Hypomagnesemia (HP:0002917)2.18764779
56Disproportionate short-trunk short stature (HP:0003521)2.08816071
57Hypoplastic labia majora (HP:0000059)2.08743385
58Polydipsia (HP:0001959)2.07646307
59Abnormal drinking behavior (HP:0030082)2.07646307
60Breast hypoplasia (HP:0003187)2.07096714
61Barrel-shaped chest (HP:0001552)2.06646212
62Colon cancer (HP:0003003)2.05966103
63Postaxial foot polydactyly (HP:0001830)2.05832554
64Amelogenesis imperfecta (HP:0000705)2.04294228
65Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03071697
66Prominent supraorbital ridges (HP:0000336)2.01729340
67Hypokinesia (HP:0002375)1.99942045
68Poor coordination (HP:0002370)1.98742055
69Septate vagina (HP:0001153)1.98223081
70Bronchomalacia (HP:0002780)1.97656898
71Abnormality of the 4th metacarpal (HP:0010012)1.97266108
72Hemiparesis (HP:0001269)1.93747299
73Meckel diverticulum (HP:0002245)1.93146034
74Fair hair (HP:0002286)1.92469067
75Ketoacidosis (HP:0001993)1.92147908
76Abnormality of the ileum (HP:0001549)1.91954596
77Polyuria (HP:0000103)1.91927910
78Nephrogenic diabetes insipidus (HP:0009806)1.89833562
79Hypoglycemic coma (HP:0001325)1.89400271
80Metabolic alkalosis (HP:0200114)1.89054957
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89013991
82Abnormality of the labia majora (HP:0012881)1.88630596
83Abnormality of the renal cortex (HP:0011035)1.88268074
84Hypokalemia (HP:0002900)1.87939475
85Hypoalbuminemia (HP:0003073)1.86623999
86Abnormal albumin level (HP:0012116)1.86623999
87Patellar aplasia (HP:0006443)1.86427520
88Abnormal hair whorl (HP:0010721)1.84531876
89Constricted visual fields (HP:0001133)1.83586577
90Cerebellar dysplasia (HP:0007033)1.83456249
91Hyperinsulinemic hypoglycemia (HP:0000825)1.80169634
92Maternal diabetes (HP:0009800)1.80042045
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.79747184
94Renal cortical cysts (HP:0000803)1.79368632
95Scrotal hypoplasia (HP:0000046)1.75508435
96Abnormal ciliary motility (HP:0012262)1.75228907
97Type I diabetes mellitus (HP:0100651)1.73356868
98Aplasia/Hypoplasia of the patella (HP:0006498)1.73131146
99Vaginal atresia (HP:0000148)1.71618151
100Hypokalemic alkalosis (HP:0001949)1.70786089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.42224482
2MUSK3.00107461
3TSSK63.00078907
4CAMKK22.75434062
5MAPK152.56557929
6CAMK1D2.28380460
7BMPR1B2.21032016
8FRK2.16463468
9TNIK2.11331799
10INSRR11.4650437
11PINK11.86789424
12IRAK11.75518210
13WEE11.68069752
14WNK41.66355190
15CAMK1G1.66160767
16PTK2B1.60884106
17PASK1.49127506
18PRKD31.41463616
19NLK1.28455143
20PBK1.20208253
21CASK1.19200516
22LATS11.16170982
23PRKG21.11806749
24STK161.08356783
25EPHA31.07780341
26IRAK21.07481891
27CAMKK11.05251362
28GRK11.02050774
29ACVR1B1.01696676
30STK38L0.98619508
31MAP3K40.95374071
32NTRK30.90757051
33CDK80.89468962
34MAPKAPK50.88680230
35MKNK20.86085531
36OXSR10.84820392
37STK390.76124452
38PRKCG0.75125381
39BMX0.73296571
40EPHA40.72969082
41CAMK10.68327232
42ADRBK20.67873388
43VRK10.66153227
44NUAK10.65987908
45MAPKAPK30.64999778
46TLK10.60006743
47WNK30.59149376
48PRKAA20.53921084
49MELK0.52026686
50PRKCE0.50309076
51FGFR20.47331172
52TYRO30.46993740
53ADRBK10.42493936
54TGFBR10.41421042
55CHUK0.40949359
56STK380.39702619
57CDK30.35989314
58PRKD20.35597350
59BUB10.35454963
60MKNK10.34503630
61CAMK40.34137540
62MAPK130.33229826
63EPHB10.32337896
64TEC0.28458673
65MAP2K70.28010869
66STK30.27999841
67YES10.27859746
68NEK20.27603195
69PAK20.27324763
70PRKCQ0.27059339
71IKBKB0.26248487
72RPS6KA60.26192244
73RPS6KA50.25831783
74HIPK20.25240552
75FER0.25218939
76PAK30.23821402
77MAP3K70.23119653
78PRKACB0.22458644
79TAF10.21987054
80GSK3A0.19597502
81PRKACA0.19415225
82MAP2K20.18792035
83DAPK20.18687141
84CDK190.18459741
85ROCK20.17696569
86MAPK70.17613548
87PIK3CG0.17612436
88OBSCN0.16972443
89PRKCH0.15577543
90CAMK2A0.15251199
91ILK0.14441430
92MAP4K20.14427760
93MAP3K20.14075081
94MET0.13304430
95EIF2AK30.13268028
96ROCK10.13165233
97MAP2K60.12013524
98PLK30.10908288
99PRKAA10.10189584
100PRKCA0.09568584

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.94756157
2Vitamin digestion and absorption_Homo sapiens_hsa049773.15066682
3Nitrogen metabolism_Homo sapiens_hsa009102.98162698
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.42971734
5Chemical carcinogenesis_Homo sapiens_hsa052042.29168214
6Linoleic acid metabolism_Homo sapiens_hsa005912.17728924
7Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.16871004
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16705778
9Sulfur metabolism_Homo sapiens_hsa009202.16645831
10Insulin secretion_Homo sapiens_hsa049112.10999753
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01709360
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.96334968
13Oxidative phosphorylation_Homo sapiens_hsa001901.93408218
14Protein export_Homo sapiens_hsa030601.80863624
15Butanoate metabolism_Homo sapiens_hsa006501.79041546
16Taste transduction_Homo sapiens_hsa047421.78529227
17Mineral absorption_Homo sapiens_hsa049781.77546857
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.71217334
19Collecting duct acid secretion_Homo sapiens_hsa049661.70460051
20Ether lipid metabolism_Homo sapiens_hsa005651.60347540
21Arginine biosynthesis_Homo sapiens_hsa002201.54907996
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.54860682
23Nicotine addiction_Homo sapiens_hsa050331.54640692
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.51887822
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48768948
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46230995
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41900836
28Hedgehog signaling pathway_Homo sapiens_hsa043401.29665715
29Ribosome_Homo sapiens_hsa030101.24826096
30ABC transporters_Homo sapiens_hsa020101.24167534
31N-Glycan biosynthesis_Homo sapiens_hsa005101.21255944
32RNA polymerase_Homo sapiens_hsa030201.17682919
33Steroid biosynthesis_Homo sapiens_hsa001001.16463337
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15633498
35Fanconi anemia pathway_Homo sapiens_hsa034601.11728316
36Parkinsons disease_Homo sapiens_hsa050121.09419746
37Propanoate metabolism_Homo sapiens_hsa006401.07932571
38Homologous recombination_Homo sapiens_hsa034401.07922433
39Estrogen signaling pathway_Homo sapiens_hsa049151.06135281
40Selenocompound metabolism_Homo sapiens_hsa004501.01428631
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95551604
42Type II diabetes mellitus_Homo sapiens_hsa049300.95227086
43Melanoma_Homo sapiens_hsa052180.95085539
44Cardiac muscle contraction_Homo sapiens_hsa042600.92771217
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91903931
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90598244
47Huntingtons disease_Homo sapiens_hsa050160.89885771
48Fat digestion and absorption_Homo sapiens_hsa049750.89612772
49Arachidonic acid metabolism_Homo sapiens_hsa005900.88255306
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87744682
51TGF-beta signaling pathway_Homo sapiens_hsa043500.87667163
52Tryptophan metabolism_Homo sapiens_hsa003800.86343466
53Phototransduction_Homo sapiens_hsa047440.85566601
54Arginine and proline metabolism_Homo sapiens_hsa003300.82526949
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81451472
56Olfactory transduction_Homo sapiens_hsa047400.78817864
57Amphetamine addiction_Homo sapiens_hsa050310.74631456
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74180314
59Bile secretion_Homo sapiens_hsa049760.72459959
60African trypanosomiasis_Homo sapiens_hsa051430.72051615
61Morphine addiction_Homo sapiens_hsa050320.70186932
62Glutathione metabolism_Homo sapiens_hsa004800.69267942
63Alzheimers disease_Homo sapiens_hsa050100.67229584
64Calcium signaling pathway_Homo sapiens_hsa040200.65815146
65Cocaine addiction_Homo sapiens_hsa050300.63757899
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63510969
67Sulfur relay system_Homo sapiens_hsa041220.63275387
68Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63229548
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59424696
70Metabolic pathways_Homo sapiens_hsa011000.59340712
71Circadian entrainment_Homo sapiens_hsa047130.58468335
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56054551
73Ovarian steroidogenesis_Homo sapiens_hsa049130.52918520
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52074661
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50928989
76Circadian rhythm_Homo sapiens_hsa047100.49504584
77Basal transcription factors_Homo sapiens_hsa030220.47351841
78Insulin resistance_Homo sapiens_hsa049310.46837757
79cAMP signaling pathway_Homo sapiens_hsa040240.46367111
80beta-Alanine metabolism_Homo sapiens_hsa004100.46347311
81Caffeine metabolism_Homo sapiens_hsa002320.45484644
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42924425
83Retinol metabolism_Homo sapiens_hsa008300.41402321
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.39306916
85Purine metabolism_Homo sapiens_hsa002300.36960529
86Glutamatergic synapse_Homo sapiens_hsa047240.33237684
87Long-term depression_Homo sapiens_hsa047300.32502212
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32485201
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.32143763
90PPAR signaling pathway_Homo sapiens_hsa033200.31387547
91Protein digestion and absorption_Homo sapiens_hsa049740.31350186
92Regulation of autophagy_Homo sapiens_hsa041400.31162296
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30985670
94Hippo signaling pathway_Homo sapiens_hsa043900.30726230
95GABAergic synapse_Homo sapiens_hsa047270.30332848
96Peroxisome_Homo sapiens_hsa041460.30270464
97Starch and sucrose metabolism_Homo sapiens_hsa005000.29921031
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.29536996
99RNA degradation_Homo sapiens_hsa030180.29389604
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28959866

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