PAICSP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.77797746
2chromatin remodeling at centromere (GO:0031055)5.73891083
3regulation of mitotic spindle checkpoint (GO:1903504)5.29450465
4regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)5.29450465
5DNA double-strand break processing (GO:0000729)5.27319376
6CENP-A containing nucleosome assembly (GO:0034080)5.17529176
7DNA replication checkpoint (GO:0000076)5.09046264
8metaphase plate congression (GO:0051310)5.00600807
9negative regulation of DNA-dependent DNA replication (GO:2000104)4.86923841
10histone exchange (GO:0043486)4.81415453
11establishment of integrated proviral latency (GO:0075713)4.64368726
12regulation of nuclear cell cycle DNA replication (GO:0033262)4.47491726
13negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.39119524
14negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.39119524
15negative regulation of mitotic sister chromatid segregation (GO:0033048)4.39119524
16negative regulation of mitotic sister chromatid separation (GO:2000816)4.39119524
17negative regulation of sister chromatid segregation (GO:0033046)4.39119524
18negative regulation of DNA recombination (GO:0045910)4.33953295
19regulation of helicase activity (GO:0051095)4.32506221
20protein localization to kinetochore (GO:0034501)4.27500740
21telomere maintenance via semi-conservative replication (GO:0032201)4.26478237
22nuclear pore complex assembly (GO:0051292)4.26144913
23IMP biosynthetic process (GO:0006188)4.25942241
24negative regulation of chromosome segregation (GO:0051985)4.25108269
25mitotic spindle checkpoint (GO:0071174)4.23438901
26nuclear pore organization (GO:0006999)4.21645265
27DNA strand elongation involved in DNA replication (GO:0006271)4.20896660
28purine nucleobase biosynthetic process (GO:0009113)4.19291141
29spindle checkpoint (GO:0031577)4.13580151
30DNA replication-independent nucleosome organization (GO:0034724)4.11888680
31DNA replication-independent nucleosome assembly (GO:0006336)4.11888680
32regulation of metaphase/anaphase transition of cell cycle (GO:1902099)4.10441256
33regulation of mitotic metaphase/anaphase transition (GO:0030071)4.10441256
34somatic hypermutation of immunoglobulin genes (GO:0016446)4.08905062
35somatic diversification of immune receptors via somatic mutation (GO:0002566)4.08905062
36mitotic recombination (GO:0006312)4.05851392
37protein neddylation (GO:0045116)3.99493904
38DNA strand elongation (GO:0022616)3.97831651
39lysine metabolic process (GO:0006553)3.95959115
40lysine catabolic process (GO:0006554)3.95959115
41proteasome assembly (GO:0043248)3.93709732
42telomere maintenance via recombination (GO:0000722)3.87001518
43establishment of chromosome localization (GO:0051303)3.86430297
44heterochromatin organization (GO:0070828)3.85294795
45regulation of mitotic sister chromatid separation (GO:0010965)3.79967686
46regulation of mitotic sister chromatid segregation (GO:0033047)3.79967686
47regulation of sister chromatid segregation (GO:0033045)3.79967686
48kinetochore organization (GO:0051383)3.78797332
49nucleobase biosynthetic process (GO:0046112)3.77267214
50synapsis (GO:0007129)3.75322804
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.74919755
52histone mRNA metabolic process (GO:0008334)3.74361426
53mitotic spindle assembly checkpoint (GO:0007094)3.74153349
54telomere maintenance via telomerase (GO:0007004)3.73957297
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.70366952
56non-recombinational repair (GO:0000726)3.70303898
57double-strand break repair via nonhomologous end joining (GO:0006303)3.70303898
58IMP metabolic process (GO:0046040)3.69896391
59mitotic G2/M transition checkpoint (GO:0044818)3.68273211
60somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.66370688
61isotype switching (GO:0045190)3.66370688
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.66370688
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.66344964
64regulation of chromosome segregation (GO:0051983)3.65845189
65spindle assembly checkpoint (GO:0071173)3.64580266
66response to X-ray (GO:0010165)3.64039758
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.62122448
68negative regulation of mitosis (GO:0045839)3.56626847
69kinetochore assembly (GO:0051382)3.55020945
70regulation of spindle checkpoint (GO:0090231)3.53595620
71telomere maintenance via telomere lengthening (GO:0010833)3.52573305
72protein K6-linked ubiquitination (GO:0085020)3.51516102
73DNA catabolic process, exonucleolytic (GO:0000738)3.51411999
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.48697654
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.44103632
76establishment of viral latency (GO:0019043)3.42845651
77negative regulation of ligase activity (GO:0051352)3.40454272
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.40454272
79ribosome assembly (GO:0042255)3.38067938
80DNA replication-dependent nucleosome organization (GO:0034723)3.34803442
81DNA replication-dependent nucleosome assembly (GO:0006335)3.34803442
82replication fork processing (GO:0031297)3.32897968
83protein localization to chromosome, centromeric region (GO:0071459)3.32750819
84negative regulation of fibroblast apoptotic process (GO:2000270)3.29210975
85mitotic sister chromatid cohesion (GO:0007064)3.28747841
86female gonad development (GO:0008585)3.26137593
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.25613578
88negative regulation of nuclear division (GO:0051784)3.24330990
89nucleotide-excision repair, DNA gap filling (GO:0006297)3.20286159
90cullin deneddylation (GO:0010388)3.17635355
91postreplication repair (GO:0006301)3.17315807
92pore complex assembly (GO:0046931)3.15026229
93sister chromatid segregation (GO:0000819)3.11953014
94RNA-dependent DNA replication (GO:0006278)3.10794526
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.10432549
96DNA replication initiation (GO:0006270)3.10039246
97termination of RNA polymerase III transcription (GO:0006386)3.07122743
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.07122743
99mitotic sister chromatid segregation (GO:0000070)3.06012640
100DNA ligation (GO:0006266)3.04630369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.09316797
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.91125229
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.02384318
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.69324780
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.38462231
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.20919885
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.11791212
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90387334
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.69991988
10AR_21909140_ChIP-Seq_LNCAP_Human2.48622768
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46403267
12ELK1_19687146_ChIP-ChIP_HELA_Human2.43322712
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40444970
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.39010463
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32604266
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.29788413
17POU5F1_16153702_ChIP-ChIP_HESCs_Human2.26495102
18VDR_22108803_ChIP-Seq_LS180_Human2.23298206
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.16065054
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15420124
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02439007
22NANOG_16153702_ChIP-ChIP_HESCs_Human2.00617501
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96374825
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.95303352
25EWS_26573619_Chip-Seq_HEK293_Human1.94288620
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.94172855
27ZNF274_21170338_ChIP-Seq_K562_Hela1.93188561
28PADI4_21655091_ChIP-ChIP_MCF-7_Human1.87755349
29FOXP3_21729870_ChIP-Seq_TREG_Human1.84395454
30VDR_23849224_ChIP-Seq_CD4+_Human1.79912537
31FUS_26573619_Chip-Seq_HEK293_Human1.75365473
32TAF15_26573619_Chip-Seq_HEK293_Human1.74877646
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.70321696
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69803092
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.67985892
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67711213
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65373279
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63685536
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58641756
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.53760926
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53465375
42MYC_18940864_ChIP-ChIP_HL60_Human1.52961829
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49413507
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49255937
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47696777
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41525424
47P300_19829295_ChIP-Seq_ESCs_Human1.40525941
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40058594
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39826862
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39133974
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.36052854
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27651587
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26257882
54IRF1_19129219_ChIP-ChIP_H3396_Human1.25360483
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25220687
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22493302
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21316962
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20130056
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18315770
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14627138
61DCP1A_22483619_ChIP-Seq_HELA_Human1.13574463
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12981546
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.11162326
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11053637
65TTF2_22483619_ChIP-Seq_HELA_Human1.10918418
66EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10036115
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.09416772
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.08630528
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06849440
70EZH2_27294783_Chip-Seq_NPCs_Mouse1.06413007
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03660223
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03660223
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03660223
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03293237
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00373146
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00190571
77ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99829376
78IGF1R_20145208_ChIP-Seq_DFB_Human0.97654956
79SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96360844
80GABP_19822575_ChIP-Seq_HepG2_Human0.93735064
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93673656
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93132959
83TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92632244
84THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91891690
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91772793
86GBX2_23144817_ChIP-Seq_PC3_Human0.91649994
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90923391
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89260866
89CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87527752
90XRN2_22483619_ChIP-Seq_HELA_Human0.86800486
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85913082
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.82812131
93SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82779004
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.82660325
95YY1_21170310_ChIP-Seq_MESCs_Mouse0.82342431
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79902785
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.79174438
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.78263565
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76565918
100TP63_19390658_ChIP-ChIP_HaCaT_Human0.75838224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.83760893
2MP0008057_abnormal_DNA_replication4.74550080
3MP0003941_abnormal_skin_development4.72731845
4MP0004957_abnormal_blastocyst_morpholog4.32791375
5MP0003693_abnormal_embryo_hatching4.05984838
6MP0003111_abnormal_nucleus_morphology3.89545837
7MP0008058_abnormal_DNA_repair3.87394284
8MP0003123_paternal_imprinting3.08800761
9MP0008932_abnormal_embryonic_tissue3.05551858
10MP0003077_abnormal_cell_cycle2.98303910
11MP0001188_hyperpigmentation2.97380688
12MP0003718_maternal_effect2.90187098
13MP0008007_abnormal_cellular_replicative2.60606722
14MP0008877_abnormal_DNA_methylation2.57900280
15MP0009697_abnormal_copulation2.12235764
16MP0009672_abnormal_birth_weight2.10607498
17MP0006072_abnormal_retinal_apoptosis2.09326120
18MP0003121_genomic_imprinting2.07168021
19MP0003890_abnormal_embryonic-extraembry1.92240643
20MP0003136_yellow_coat_color1.89332449
21MP0000579_abnormal_nail_morphology1.88544135
22MP0003567_abnormal_fetal_cardiomyocyte1.85342085
23MP0003195_calcinosis1.71348976
24MP0010307_abnormal_tumor_latency1.68028433
25MP0001293_anophthalmia1.63987660
26MP0003786_premature_aging1.62431208
27MP0006292_abnormal_olfactory_placode1.55752234
28MP0003646_muscle_fatigue1.52663625
29MP0003937_abnormal_limbs/digits/tail_de1.51575402
30MP0001177_atelectasis1.42268397
31MP0004133_heterotaxia1.38493568
32MP0001730_embryonic_growth_arrest1.35154955
33MP0002254_reproductive_system_inflammat1.33939890
34MP0004197_abnormal_fetal_growth/weight/1.31465259
35MP0000350_abnormal_cell_proliferation1.28568716
36MP0002090_abnormal_vision1.27188618
37MP0002751_abnormal_autonomic_nervous1.25194902
38MP0009703_decreased_birth_body1.23522895
39MP0006035_abnormal_mitochondrial_morpho1.23342496
40MP0003787_abnormal_imprinting1.20438888
41MP0002102_abnormal_ear_morphology1.12704267
42MP0003137_abnormal_impulse_conducting1.12501590
43MP0006054_spinal_hemorrhage1.11965639
44MP0001697_abnormal_embryo_size1.08871216
45MP0002085_abnormal_embryonic_tissue1.08794944
46MP0005395_other_phenotype1.08415597
47MP0002084_abnormal_developmental_patter1.08050550
48MP0001929_abnormal_gametogenesis1.07835753
49MP0003119_abnormal_digestive_system1.06448703
50MP0002796_impaired_skin_barrier1.06157313
51MP0004215_abnormal_myocardial_fiber1.05011523
52MP0010352_gastrointestinal_tract_polyps1.03578308
53MP0006036_abnormal_mitochondrial_physio0.98270719
54MP0003806_abnormal_nucleotide_metabolis0.98255347
55MP0001485_abnormal_pinna_reflex0.96076939
56MP0002210_abnormal_sex_determination0.95042844
57MP0005380_embryogenesis_phenotype0.93518123
58MP0001672_abnormal_embryogenesis/_devel0.93518123
59MP0002080_prenatal_lethality0.92098074
60MP0002736_abnormal_nociception_after0.91696925
61MP0008789_abnormal_olfactory_epithelium0.88186632
62MP0002111_abnormal_tail_morphology0.87288600
63MP0000647_abnormal_sebaceous_gland0.87214338
64MP0001286_abnormal_eye_development0.86730682
65MP0000653_abnormal_sex_gland0.86510544
66MP0005220_abnormal_exocrine_pancreas0.86483337
67MP0001145_abnormal_male_reproductive0.85454986
68MP0002233_abnormal_nose_morphology0.85212675
69MP0005253_abnormal_eye_physiology0.81206447
70MP0010030_abnormal_orbit_morphology0.79739418
71MP0001299_abnormal_eye_distance/0.79476380
72MP0005367_renal/urinary_system_phenotyp0.74351113
73MP0000516_abnormal_urinary_system0.74351113
74MP0000313_abnormal_cell_death0.74244867
75MP0001119_abnormal_female_reproductive0.72656202
76MP0002396_abnormal_hematopoietic_system0.72494816
77MP0010234_abnormal_vibrissa_follicle0.72407269
78MP0002697_abnormal_eye_size0.69969907
79MP0002938_white_spotting0.69232793
80MP0010678_abnormal_skin_adnexa0.66168298
81MP0001529_abnormal_vocalization0.64439363
82MP0003221_abnormal_cardiomyocyte_apopto0.63015654
83MP0001324_abnormal_eye_pigmentation0.61914951
84MP0002160_abnormal_reproductive_system0.61477537
85MP0003698_abnormal_male_reproductive0.61350212
86MP0005332_abnormal_amino_acid0.60913277
87MP0005551_abnormal_eye_electrophysiolog0.60538068
88MP0002019_abnormal_tumor_incidence0.60026724
89MP0002086_abnormal_extraembryonic_tissu0.59929940
90MP0002088_abnormal_embryonic_growth/wei0.58621059
91MP0003984_embryonic_growth_retardation0.57840332
92MP0005075_abnormal_melanosome_morpholog0.56306004
93MP0003755_abnormal_palate_morphology0.55727842
94MP0004147_increased_porphyrin_level0.55441692
95MP0000383_abnormal_hair_follicle0.54775830
96MP0005389_reproductive_system_phenotype0.52381179
97MP0003699_abnormal_female_reproductive0.52362981
98MP0001186_pigmentation_phenotype0.51890866
99MP0005391_vision/eye_phenotype0.51592244
100MP0003186_abnormal_redox_activity0.50817786

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.60564275
2Chromsome breakage (HP:0040012)5.17055506
3Abnormality of the labia minora (HP:0012880)4.87463678
4Birth length less than 3rd percentile (HP:0003561)4.82425866
5Abnormality of chromosome stability (HP:0003220)4.24920445
6Colon cancer (HP:0003003)4.03499750
7Meckel diverticulum (HP:0002245)3.85336034
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.65231747
9Spastic diplegia (HP:0001264)3.63959736
10Abnormality of the ileum (HP:0001549)3.60907079
11Agnosia (HP:0010524)3.51167525
12Abnormality of the preputium (HP:0100587)3.50099176
13Multiple enchondromatosis (HP:0005701)3.34030046
14Supernumerary spleens (HP:0009799)3.30197445
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.24324551
16Rhabdomyosarcoma (HP:0002859)3.23846960
17Ependymoma (HP:0002888)3.22656301
18Duodenal stenosis (HP:0100867)3.15563710
19Small intestinal stenosis (HP:0012848)3.15563710
20Nephroblastoma (Wilms tumor) (HP:0002667)3.15060125
21Methylmalonic acidemia (HP:0002912)3.09409751
22Medulloblastoma (HP:0002885)3.07542321
23Abnormal lung lobation (HP:0002101)3.01367079
24Biliary tract neoplasm (HP:0100574)2.99015341
25Embryonal renal neoplasm (HP:0011794)2.96280892
26Abnormality of serum amino acid levels (HP:0003112)2.80865720
27Stenosis of the external auditory canal (HP:0000402)2.72881089
28Neoplasm of the adrenal gland (HP:0100631)2.72138149
29Abnormality of the duodenum (HP:0002246)2.65312524
30Absent radius (HP:0003974)2.55778044
31Volvulus (HP:0002580)2.52792870
32Abnormality of methionine metabolism (HP:0010901)2.49466707
33Ovarian neoplasm (HP:0100615)2.47720601
34Abnormality of the pons (HP:0007361)2.47013823
35Methylmalonic aciduria (HP:0012120)2.44562635
36Congenital, generalized hypertrichosis (HP:0004540)2.41811645
37Absent forearm bone (HP:0003953)2.40900272
38Aplasia involving forearm bones (HP:0009822)2.40900272
39Clubbing of toes (HP:0100760)2.40662265
40Sloping forehead (HP:0000340)2.38144764
41Neoplasm of the colon (HP:0100273)2.34786675
42Glioma (HP:0009733)2.34159089
43Acanthocytosis (HP:0001927)2.32727422
44Pancreatic islet-cell hyperplasia (HP:0004510)2.24749281
45Carpal bone hypoplasia (HP:0001498)2.24599721
46Abolished electroretinogram (ERG) (HP:0000550)2.24366728
47Cortical dysplasia (HP:0002539)2.22988489
48Progressive inability to walk (HP:0002505)2.22973192
49Hyperglycinemia (HP:0002154)2.19467718
50Hypoplasia of the pons (HP:0012110)2.17942551
51Ectopic kidney (HP:0000086)2.16991319
52Neoplasm of the oral cavity (HP:0100649)2.15328606
53Increased hepatocellular lipid droplets (HP:0006565)2.14802649
54Myelodysplasia (HP:0002863)2.13235133
55Breast carcinoma (HP:0003002)2.13131557
56Uterine neoplasm (HP:0010784)2.08770071
57Horseshoe kidney (HP:0000085)2.07971133
58Neoplasm of the small intestine (HP:0100833)2.07302541
59Lipid accumulation in hepatocytes (HP:0006561)2.07123312
60Triphalangeal thumb (HP:0001199)2.06670752
61Abnormality of the vitamin B12 metabolism (HP:0004341)2.04654245
62Abnormality of the carotid arteries (HP:0005344)2.04207814
63Abnormal hair whorl (HP:0010721)2.00106068
64Abnormality of the astrocytes (HP:0100707)1.99117730
65Astrocytoma (HP:0009592)1.99117730
66Neoplasm of striated muscle (HP:0009728)1.97203161
67Abnormality of serine family amino acid metabolism (HP:0010894)1.96740665
68Abnormality of glycine metabolism (HP:0010895)1.96740665
69Megaloblastic anemia (HP:0001889)1.96176494
70Congenital stationary night blindness (HP:0007642)1.94952437
71Malignant gastrointestinal tract tumors (HP:0006749)1.93730729
72Gastrointestinal carcinoma (HP:0002672)1.93730729
73Hypoglycemic seizures (HP:0002173)1.91562538
74Breast aplasia (HP:0100783)1.90995460
75Neoplasm of the rectum (HP:0100743)1.89893852
76Abnormality of homocysteine metabolism (HP:0010919)1.87346473
77Homocystinuria (HP:0002156)1.87346473
78Gonadotropin excess (HP:0000837)1.86947551
79Abnormality of vitamin B metabolism (HP:0004340)1.86113296
80Duplicated collecting system (HP:0000081)1.86032142
81Absent septum pellucidum (HP:0001331)1.81594799
82Clitoromegaly (HP:0000057)1.81007152
83Abnormality of the anterior horn cell (HP:0006802)1.79943314
84Degeneration of anterior horn cells (HP:0002398)1.79943314
85Hypoplastic female external genitalia (HP:0012815)1.79444503
86Acute encephalopathy (HP:0006846)1.77300198
87Symptomatic seizures (HP:0011145)1.77246409
88Oral leukoplakia (HP:0002745)1.76450630
89Aplasia/Hypoplasia of the breasts (HP:0010311)1.74787678
90Abnormality of the septum pellucidum (HP:0007375)1.74766560
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.74184916
92Dandy-Walker malformation (HP:0001305)1.73699584
93Bile duct proliferation (HP:0001408)1.72975788
94Abnormal biliary tract physiology (HP:0012439)1.72975788
95Sensory axonal neuropathy (HP:0003390)1.72248719
96Abnormality of the clitoris (HP:0000056)1.70734064
97Labial hypoplasia (HP:0000066)1.70026087
98Small hand (HP:0200055)1.68761181
99Acute necrotizing encephalopathy (HP:0006965)1.68165255
100Cafe-au-lait spot (HP:0000957)1.66670170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.00106314
2TTK3.76815512
3MKNK23.64279940
4EIF2AK33.61472768
5BUB13.49190746
6PLK33.27485581
7WNK33.25781571
8ZAK3.15187255
9MST43.05445200
10TSSK62.80237219
11SRPK12.69449352
12NUAK12.53401675
13MKNK12.52808289
14EIF2AK12.41127156
15WEE12.12910345
16BRSK22.08434837
17VRK12.07380517
18FRK1.93482189
19PLK11.87527561
20PLK41.86591273
21TNIK1.83415496
22NEK11.68786610
23PLK21.65286694
24VRK21.64518563
25ERBB31.61373781
26ACVR1B1.59945136
27TRIM281.54763381
28TAF11.50324034
29PBK1.40267534
30EIF2AK21.32760907
31BRAF1.31831181
32GRK11.25490885
33OXSR11.23994221
34STK161.16886596
35STK38L1.13624479
36BMPR1B1.10124485
37CHEK21.09083982
38CDK191.05886577
39TIE11.03062146
40ATR1.02225102
41ALK0.89428726
42ATM0.82369517
43STK100.81730813
44AURKB0.80680912
45BRSK10.80462286
46MAP3K100.80135321
47ERBB40.77392665
48DYRK30.74371070
49DYRK20.72574155
50CHEK10.69116444
51FGFR20.68756886
52TEC0.68602795
53CLK10.68085504
54INSRR0.65746348
55CDK30.65513751
56STK240.65447668
57STK30.64689698
58FLT30.60659360
59CSNK1G10.57834177
60CASK0.51335774
61PNCK0.51160702
62MAP3K80.50268519
63CDK10.47304935
64CSNK2A10.44344820
65NEK20.44271170
66MAP3K90.43984782
67PAK40.43940948
68NLK0.43467867
69FGFR10.43436677
70DMPK0.42113833
71CSNK2A20.41901659
72PRKCG0.40658703
73AURKA0.40435854
74PASK0.39995165
75CSNK1E0.39536831
76CDK20.39193346
77PRKDC0.38568263
78EPHA40.37204745
79NME10.35631590
80BRD40.33725612
81CSNK1G30.33626137
82TGFBR10.32619421
83BCR0.32542750
84CDK70.30808665
85STK40.29907617
86CSNK1G20.29532934
87ADRBK20.28140715
88PRKCI0.26366748
89STK390.24609276
90TLK10.24004515
91RPS6KA40.23323488
92CSNK1A1L0.22330011
93RPS6KA50.22190474
94DYRK1A0.21878762
95TGFBR20.21207584
96PINK10.18794698
97PDK20.17320201
98MELK0.16570367
99CDK60.16050000
100EGFR0.15830275

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.69757759
2Proteasome_Homo sapiens_hsa030504.18379315
3DNA replication_Homo sapiens_hsa030303.73987652
4Homologous recombination_Homo sapiens_hsa034403.34001064
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.33458196
6Non-homologous end-joining_Homo sapiens_hsa034503.30063807
7RNA polymerase_Homo sapiens_hsa030202.75586498
8Fanconi anemia pathway_Homo sapiens_hsa034602.49454376
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.37628178
10Cell cycle_Homo sapiens_hsa041102.33806755
11Propanoate metabolism_Homo sapiens_hsa006402.26933444
12RNA transport_Homo sapiens_hsa030132.25548425
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.11899414
14One carbon pool by folate_Homo sapiens_hsa006702.11709910
15RNA degradation_Homo sapiens_hsa030182.07867583
16Spliceosome_Homo sapiens_hsa030402.02218773
17Protein export_Homo sapiens_hsa030601.92790806
18Basal transcription factors_Homo sapiens_hsa030221.81021986
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77015470
20Nucleotide excision repair_Homo sapiens_hsa034201.73606826
21Vitamin B6 metabolism_Homo sapiens_hsa007501.71798025
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69716258
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56970839
24Base excision repair_Homo sapiens_hsa034101.55761367
25Steroid biosynthesis_Homo sapiens_hsa001001.49894201
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44933165
27Pyruvate metabolism_Homo sapiens_hsa006201.41816763
28Pyrimidine metabolism_Homo sapiens_hsa002401.41568521
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.40075231
30mRNA surveillance pathway_Homo sapiens_hsa030151.28821363
31Selenocompound metabolism_Homo sapiens_hsa004501.28282030
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23618448
33Purine metabolism_Homo sapiens_hsa002301.21695456
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20508301
35Oocyte meiosis_Homo sapiens_hsa041141.18696983
36Caffeine metabolism_Homo sapiens_hsa002321.17451245
37Fatty acid elongation_Homo sapiens_hsa000621.12862442
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12567766
39Phototransduction_Homo sapiens_hsa047441.08951484
40Oxidative phosphorylation_Homo sapiens_hsa001901.02559076
41p53 signaling pathway_Homo sapiens_hsa041150.99063555
42Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98548177
43Parkinsons disease_Homo sapiens_hsa050120.95351778
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86787134
45Biosynthesis of amino acids_Homo sapiens_hsa012300.86473219
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85919597
47Glutathione metabolism_Homo sapiens_hsa004800.83380779
48Vitamin digestion and absorption_Homo sapiens_hsa049770.82026731
49Carbon metabolism_Homo sapiens_hsa012000.75955677
50Fatty acid degradation_Homo sapiens_hsa000710.72730493
51Nitrogen metabolism_Homo sapiens_hsa009100.71549549
52Huntingtons disease_Homo sapiens_hsa050160.70625198
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66060703
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65317252
55Tryptophan metabolism_Homo sapiens_hsa003800.63592626
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61971571
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61774853
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61553537
59Retinol metabolism_Homo sapiens_hsa008300.60624297
60Metabolic pathways_Homo sapiens_hsa011000.56110885
61beta-Alanine metabolism_Homo sapiens_hsa004100.54208496
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53274371
63Fatty acid metabolism_Homo sapiens_hsa012120.51492971
64Alzheimers disease_Homo sapiens_hsa050100.50083176
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49341712
66Folate biosynthesis_Homo sapiens_hsa007900.48352796
67Peroxisome_Homo sapiens_hsa041460.48299167
68Epstein-Barr virus infection_Homo sapiens_hsa051690.47313359
69Arginine and proline metabolism_Homo sapiens_hsa003300.44832225
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42821294
71TGF-beta signaling pathway_Homo sapiens_hsa043500.42702098
72Systemic lupus erythematosus_Homo sapiens_hsa053220.42607290
73Lysine degradation_Homo sapiens_hsa003100.41074131
74Hippo signaling pathway_Homo sapiens_hsa043900.40813372
75N-Glycan biosynthesis_Homo sapiens_hsa005100.40467865
76Ribosome_Homo sapiens_hsa030100.40066965
77Ether lipid metabolism_Homo sapiens_hsa005650.36051499
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35290977
79Basal cell carcinoma_Homo sapiens_hsa052170.35188582
80Wnt signaling pathway_Homo sapiens_hsa043100.35109838
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34113481
82Butanoate metabolism_Homo sapiens_hsa006500.33524962
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.33482080
84Starch and sucrose metabolism_Homo sapiens_hsa005000.33391981
85Tight junction_Homo sapiens_hsa045300.32050286
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28847651
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28386338
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27253152
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25769527
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24349247
91Chemical carcinogenesis_Homo sapiens_hsa052040.23791887
92Nicotine addiction_Homo sapiens_hsa050330.21877919
93Alcoholism_Homo sapiens_hsa050340.21849494
94Sulfur relay system_Homo sapiens_hsa041220.21360924
95Galactose metabolism_Homo sapiens_hsa000520.20958184
96Sulfur metabolism_Homo sapiens_hsa009200.20535432
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19752130
98Linoleic acid metabolism_Homo sapiens_hsa005910.19500713
99Taste transduction_Homo sapiens_hsa047420.18748506
100Olfactory transduction_Homo sapiens_hsa047400.18473625

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