PAIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)7.17687337
2presynaptic membrane organization (GO:0097090)6.23335806
3short-term memory (GO:0007614)5.97111865
4postsynaptic membrane organization (GO:0001941)5.94069375
5regulation of DNA methylation (GO:0044030)5.87115849
6negative regulation of execution phase of apoptosis (GO:1900118)5.57423963
7piRNA metabolic process (GO:0034587)5.18387490
8synapsis (GO:0007129)5.15479887
9neuron cell-cell adhesion (GO:0007158)4.99985149
10meiotic cell cycle (GO:0051321)4.83792986
11spermatid nucleus differentiation (GO:0007289)4.80492308
12mitotic metaphase plate congression (GO:0007080)4.76268062
13protein localization to chromosome, centromeric region (GO:0071459)4.75036371
14protein localization to kinetochore (GO:0034501)4.71758784
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.70333055
16mitotic chromosome condensation (GO:0007076)4.39080458
17limb bud formation (GO:0060174)4.36790878
18CENP-A containing nucleosome assembly (GO:0034080)4.31682101
19positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.31257874
20positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.31257874
21positive regulation of mitotic sister chromatid separation (GO:1901970)4.31257874
22regulation of female gonad development (GO:2000194)4.27208864
23positive regulation of chromosome segregation (GO:0051984)4.16261068
24metaphase plate congression (GO:0051310)4.14918718
25establishment of chromosome localization (GO:0051303)4.09468452
26central nervous system myelination (GO:0022010)4.08781631
27axon ensheathment in central nervous system (GO:0032291)4.08781631
28chromatin remodeling at centromere (GO:0031055)4.07763874
29negative regulation of keratinocyte proliferation (GO:0010839)4.02184887
30protein localization to chromosome (GO:0034502)3.97339917
31chromosome organization involved in meiosis (GO:0070192)3.96142371
32female gamete generation (GO:0007292)3.82023636
33neuronal action potential propagation (GO:0019227)3.81919359
34retina layer formation (GO:0010842)3.81341937
35positive regulation of synapse assembly (GO:0051965)3.77726977
36regulation of histone H3-K9 methylation (GO:0051570)3.75157345
37retinal cone cell development (GO:0046549)3.66180753
38interkinetic nuclear migration (GO:0022027)3.64670175
39microtubule depolymerization (GO:0007019)3.58047674
40protein localization to synapse (GO:0035418)3.56741554
41nuclear pore organization (GO:0006999)3.55979125
42regulation of spindle organization (GO:0090224)3.55382244
43DNA replication-independent nucleosome organization (GO:0034724)3.54478780
44DNA replication-independent nucleosome assembly (GO:0006336)3.54478780
45histone exchange (GO:0043486)3.52952893
46organ growth (GO:0035265)3.51680315
47gene silencing by RNA (GO:0031047)3.51221451
48positive regulation of protein kinase C signaling (GO:0090037)3.44910819
49male meiosis I (GO:0007141)3.44670250
50paraxial mesoderm development (GO:0048339)3.41149339
51cerebral cortex radially oriented cell migration (GO:0021799)3.39630215
52synaptonemal complex assembly (GO:0007130)3.33066865
53generation of neurons (GO:0048699)3.32989686
54righting reflex (GO:0060013)3.32857209
55glycerophospholipid catabolic process (GO:0046475)3.31467448
56positive regulation of histone H3-K4 methylation (GO:0051571)3.30300924
57DNA replication-dependent nucleosome assembly (GO:0006335)3.27262681
58DNA replication-dependent nucleosome organization (GO:0034723)3.27262681
59attachment of spindle microtubules to kinetochore (GO:0008608)3.25503834
60meiotic cell cycle process (GO:1903046)3.23548010
61positive regulation of steroid hormone secretion (GO:2000833)3.23377368
62kinetochore organization (GO:0051383)3.23135609
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.21025138
64nuclear pore complex assembly (GO:0051292)3.18693030
65regulation of timing of cell differentiation (GO:0048505)3.17488471
66membrane assembly (GO:0071709)3.12004830
67oocyte development (GO:0048599)3.11968895
68regulation of meiosis (GO:0040020)3.11932266
69cilium movement (GO:0003341)3.11871353
70spindle checkpoint (GO:0031577)3.11571684
71regulation of chromosome segregation (GO:0051983)3.09850531
72negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.09091544
73regulation of pigment cell differentiation (GO:0050932)3.08760308
74male meiosis (GO:0007140)3.08499352
75regulation of double-strand break repair via homologous recombination (GO:0010569)3.08385744
76proteasome assembly (GO:0043248)3.08303744
77eye photoreceptor cell differentiation (GO:0001754)3.07707260
78photoreceptor cell differentiation (GO:0046530)3.07707260
79regulation of synapse assembly (GO:0051963)3.07451387
80female gonad development (GO:0008585)3.05877609
81regulation of development, heterochronic (GO:0040034)3.05846773
82DNA methylation involved in gamete generation (GO:0043046)3.05181057
83regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04690598
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04690598
85microtubule polymerization or depolymerization (GO:0031109)3.01690437
86limb development (GO:0060173)3.01683939
87appendage development (GO:0048736)3.01683939
88mitotic sister chromatid segregation (GO:0000070)3.01642464
89meiotic nuclear division (GO:0007126)3.00722037
90negative regulation of neurotransmitter secretion (GO:0046929)2.98775990
91meiosis I (GO:0007127)2.98279975
92positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.97694675
93synaptonemal complex organization (GO:0070193)2.97383619
94sister chromatid cohesion (GO:0007062)2.96504441
95epithelial cilium movement (GO:0003351)2.96301042
96regulation of acrosome reaction (GO:0060046)2.96243706
97mitotic sister chromatid cohesion (GO:0007064)2.94770845
98regulation of mitotic sister chromatid separation (GO:0010965)2.94707961
99regulation of mitotic sister chromatid segregation (GO:0033047)2.94707961
100regulation of sister chromatid segregation (GO:0033045)2.94707961
101sympathetic nervous system development (GO:0048485)2.93273770
102cullin deneddylation (GO:0010388)2.93091599
103forebrain neuron differentiation (GO:0021879)2.92385857
104regulation of spindle checkpoint (GO:0090231)2.90473840
105negative regulation of neurotransmitter transport (GO:0051589)2.89919604
106GMP metabolic process (GO:0046037)2.89505309
107nonmotile primary cilium assembly (GO:0035058)2.89376973
108neuron recognition (GO:0008038)2.88587794
109sister chromatid segregation (GO:0000819)2.88497997
110regulation of keratinocyte proliferation (GO:0010837)2.88426619
111regulation of mitotic spindle organization (GO:0060236)2.87260232
112chromosome segregation (GO:0007059)2.84940509
113regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.84496334
114mitotic spindle checkpoint (GO:0071174)2.83848488
115metanephric nephron tubule development (GO:0072234)2.83448724
116metanephric tubule development (GO:0072170)2.83448724
117positive regulation of amino acid transport (GO:0051957)2.81699629
118regulation of cell maturation (GO:1903429)2.81305458
119positive regulation of meiosis (GO:0045836)2.80835541
120translesion synthesis (GO:0019985)2.79734156
121axonemal dynein complex assembly (GO:0070286)2.79403921
122regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.78762854
123vocalization behavior (GO:0071625)2.78759535
124mitotic G2/M transition checkpoint (GO:0044818)2.77867451
125regulation of DNA endoreduplication (GO:0032875)2.77199170
126negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.76957464
127startle response (GO:0001964)2.75640580
128mitotic nuclear envelope disassembly (GO:0007077)2.74974722
129primitive streak formation (GO:0090009)2.74834355
130spinal cord motor neuron differentiation (GO:0021522)2.73878485
131DNA replication checkpoint (GO:0000076)2.73671969
132genitalia morphogenesis (GO:0035112)2.72975137
133neurotransmitter-gated ion channel clustering (GO:0072578)2.72785349
134positive regulation of meiotic cell cycle (GO:0051446)2.71987317
135regulation of mitotic spindle checkpoint (GO:1903504)2.71633858
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.71633858
137anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.70737547
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70432691
139endocrine hormone secretion (GO:0060986)2.70377423
140dendrite development (GO:0016358)2.69872589
141regulation of meiosis I (GO:0060631)2.69830335
142oogenesis (GO:0048477)2.69377006
143negative regulation of histone methylation (GO:0031061)2.68809573
144regulation of centrosome cycle (GO:0046605)2.68448491
145long-chain fatty acid biosynthetic process (GO:0042759)2.68236543
146forebrain neuron development (GO:0021884)2.67879715
147chromatin assembly or disassembly (GO:0006333)2.67558457
148kinetochore assembly (GO:0051382)2.67244267
149negative regulation of chromosome segregation (GO:0051985)2.67153233
150protein neddylation (GO:0045116)2.66767681
151DNA strand elongation involved in DNA replication (GO:0006271)2.66548055
152cranial nerve morphogenesis (GO:0021602)2.66461537
153establishment of integrated proviral latency (GO:0075713)2.66446162
154negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65475202
155negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65475202
156negative regulation of mitotic sister chromatid separation (GO:2000816)2.65475202
157negative regulation of sister chromatid segregation (GO:0033046)2.65475202
158negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65475202
159regulation of protein kinase A signaling (GO:0010738)2.64808698
160gamma-aminobutyric acid signaling pathway (GO:0007214)2.64670402
161DNA strand elongation (GO:0022616)2.63053128
162postreplication repair (GO:0006301)2.62395336
163regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.62379994
164regulation of centriole replication (GO:0046599)2.62053295
165centriole replication (GO:0007099)2.61580881
166centrosome duplication (GO:0051298)2.61264089
167regulation of meiotic cell cycle (GO:0051445)2.61122195
168regulation of steroid hormone secretion (GO:2000831)2.59520477
169positive regulation of cell cycle checkpoint (GO:1901978)2.59069003
170regulation of synaptic transmission, GABAergic (GO:0032228)2.58220015
171otic vesicle formation (GO:0030916)2.57615652
172nucleotide-excision repair, DNA gap filling (GO:0006297)2.57604854
173keratinocyte development (GO:0003334)2.57421295
174negative regulation of dendrite morphogenesis (GO:0050774)2.57379145
175metanephric epithelium development (GO:0072207)2.55212408
176mechanosensory behavior (GO:0007638)2.52819263
177protein heterotetramerization (GO:0051290)2.52506294
178photoreceptor cell maintenance (GO:0045494)2.51188599
179acrosome assembly (GO:0001675)2.50981906
180metanephric nephron epithelium development (GO:0072243)2.49925560
181omega-hydroxylase P450 pathway (GO:0097267)2.46684963
182negative regulation of homotypic cell-cell adhesion (GO:0034111)2.45579626
183pyrimidine nucleobase catabolic process (GO:0006208)2.45350576
184regulation of gene expression by genetic imprinting (GO:0006349)2.44956300
185cerebral cortex cell migration (GO:0021795)2.43953104
186glutamate receptor signaling pathway (GO:0007215)2.43696144
187GTP biosynthetic process (GO:0006183)2.43128654
188ionotropic glutamate receptor signaling pathway (GO:0035235)2.42722017
189axoneme assembly (GO:0035082)2.42208949
190oligodendrocyte differentiation (GO:0048709)2.42199831
191positive regulation of dendritic spine development (GO:0060999)2.41901901
192cornea development in camera-type eye (GO:0061303)2.41619722
193DNA ligation (GO:0006266)2.41266280
194positive regulation of synaptic transmission, GABAergic (GO:0032230)2.40999841
195melanin metabolic process (GO:0006582)2.39522194
196regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37807609
197serotonin receptor signaling pathway (GO:0007210)2.37633234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.68355837
2EZH2_22144423_ChIP-Seq_EOC_Human3.96305166
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.89968765
4GBX2_23144817_ChIP-Seq_PC3_Human3.51602220
5TAF15_26573619_Chip-Seq_HEK293_Human3.27951131
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16913381
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06091094
8AR_21909140_ChIP-Seq_LNCAP_Human3.00773614
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.95951556
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76665018
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73316262
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.72253406
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.62572470
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.61085044
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.60394546
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57462684
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.56438571
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54386456
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52102219
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.47404709
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.45057086
22IGF1R_20145208_ChIP-Seq_DFB_Human2.41967485
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.41633200
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.40891955
25VDR_22108803_ChIP-Seq_LS180_Human2.39445105
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.29603245
27RNF2_27304074_Chip-Seq_NSC_Mouse2.27580966
28PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.26517980
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24990080
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18343946
31CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14089287
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10462067
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.08742325
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02551624
35MYC_18555785_ChIP-Seq_MESCs_Mouse2.01458008
36AR_21572438_ChIP-Seq_LNCaP_Human2.00487534
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.00368807
38FUS_26573619_Chip-Seq_HEK293_Human1.99387987
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99247607
40P300_19829295_ChIP-Seq_ESCs_Human1.93671777
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92980485
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92980485
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92980485
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89679518
45RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89679518
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86270515
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85256504
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84660296
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84570640
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.80871529
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79893655
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.77473905
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76178915
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.75740997
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75413052
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72511082
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.71293997
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70993342
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70131211
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.69105314
61ER_23166858_ChIP-Seq_MCF-7_Human1.67241646
62ELK1_19687146_ChIP-ChIP_HELA_Human1.67116802
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.66596871
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64801124
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.64574061
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64288232
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.63667034
68TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62523640
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62016077
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.61696019
71IRF1_19129219_ChIP-ChIP_H3396_Human1.59654341
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58215709
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.57305930
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56411965
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56081131
76SMAD4_21799915_ChIP-Seq_A2780_Human1.54525359
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54154982
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53676240
79EZH2_27294783_Chip-Seq_ESCs_Mouse1.53028869
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.52033944
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.50354424
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.49875434
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.49456693
84P53_22387025_ChIP-Seq_ESCs_Mouse1.49282104
85SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48698545
86MYC_19030024_ChIP-ChIP_MESCs_Mouse1.46652220
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46492341
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45171488
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.44160552
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.43887027
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.43545310
92P300_18555785_Chip-Seq_ESCs_Mouse1.43390266
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.41481519
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41360837
95* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.41317133
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.39486411
97MYC_19079543_ChIP-ChIP_MESCs_Mouse1.37651290
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37115001
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.36685578
100NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36115165
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35656898
102* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34984090
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.34754782
104MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34635276
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34609795
106* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.34089457
107NMYC_18555785_Chip-Seq_ESCs_Mouse1.33280082
108RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33275770
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32551723
110SOX2_18555785_Chip-Seq_ESCs_Mouse1.31743634
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31188484
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28218892
113RUNX1_27457419_Chip-Seq_LIVER_Mouse1.27784537
114EWS_26573619_Chip-Seq_HEK293_Human1.27418169
115GATA1_26923725_Chip-Seq_HPCs_Mouse1.27184843
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26475388
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26322941
118DCP1A_22483619_ChIP-Seq_HELA_Human1.25879890
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.24611951
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22574050
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22340816
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22290658
123THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21530382
124KDM2B_26808549_Chip-Seq_REH_Human1.21184588
125OCT4_18555785_Chip-Seq_ESCs_Mouse1.21098904
126STAT3_23295773_ChIP-Seq_U87_Human1.20890276
127RUNX2_22187159_ChIP-Seq_PCA_Human1.20286842
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19694310
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19680440
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19680440
131TAL1_26923725_Chip-Seq_HPCs_Mouse1.19160476
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19139957
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16845212
134HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15627259
135FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15401416
136JUN_21703547_ChIP-Seq_K562_Human1.15138014
137PRDM14_20953172_ChIP-Seq_ESCs_Human1.14840404
138ZFX_18555785_Chip-Seq_ESCs_Mouse1.14391705
139AR_25329375_ChIP-Seq_VCAP_Human1.13859566
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13687500
141KLF4_18555785_Chip-Seq_ESCs_Mouse1.13581860
142MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11207388
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10482796
144HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10160415
145REST_21632747_ChIP-Seq_MESCs_Mouse1.10017429
146TP63_19390658_ChIP-ChIP_HaCaT_Human1.09073046
147YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08851651
148TP53_18474530_ChIP-ChIP_U2OS_Human1.08341848
149NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08260611
150* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03876167
151SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03670262
152EP300_21415370_ChIP-Seq_HL-1_Mouse1.02321372
153FOXP3_21729870_ChIP-Seq_TREG_Human1.01955447
154ETS1_20019798_ChIP-Seq_JURKAT_Human1.01015668
155ZNF274_21170338_ChIP-Seq_K562_Hela1.01004998
156MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98867627
157JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98642404
158VDR_23849224_ChIP-Seq_CD4+_Human0.98180007
159MYC_18940864_ChIP-ChIP_HL60_Human0.96464073
160CBP_20019798_ChIP-Seq_JUKART_Human0.96411131
161IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96411131
162NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94818293
163HTT_18923047_ChIP-ChIP_STHdh_Human0.92032399
164MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.90295847
165GABP_19822575_ChIP-Seq_HepG2_Human0.89427822
166TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88748775
167SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88513349
168* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87669297
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85775695
170TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84036286
171SOX17_20123909_ChIP-Seq_XEN_Mouse0.83440932

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.19101987
2MP0003880_abnormal_central_pattern4.37444949
3MP0001188_hyperpigmentation4.31731028
4MP0006292_abnormal_olfactory_placode3.61598405
5MP0005409_darkened_coat_color3.06111027
6MP0010234_abnormal_vibrissa_follicle3.00836073
7MP0003693_abnormal_embryo_hatching2.90591871
8MP0003890_abnormal_embryonic-extraembry2.84029876
9MP0010094_abnormal_chromosome_stability2.82629938
10MP0009379_abnormal_foot_pigmentation2.76979386
11MP0004381_abnormal_hair_follicle2.73713999
12MP0002102_abnormal_ear_morphology2.58777452
13MP0008058_abnormal_DNA_repair2.56505884
14MP0000566_synostosis2.54586151
15MP0008057_abnormal_DNA_replication2.48058263
16MP0010030_abnormal_orbit_morphology2.42292654
17MP0002234_abnormal_pharynx_morphology2.38437398
18MP0003077_abnormal_cell_cycle2.38434827
19MP0006276_abnormal_autonomic_nervous2.33852866
20MP0003111_abnormal_nucleus_morphology2.21917638
21MP0008932_abnormal_embryonic_tissue2.13504145
22MP0004270_analgesia2.06810001
23MP0004957_abnormal_blastocyst_morpholog2.03233435
24MP0004742_abnormal_vestibular_system1.93351086
25MP0005395_other_phenotype1.90390998
26MP0003315_abnormal_perineum_morphology1.89701791
27MP0001968_abnormal_touch/_nociception1.86156733
28MP0003718_maternal_effect1.82878427
29MP0000778_abnormal_nervous_system1.80993242
30MP0002210_abnormal_sex_determination1.79928287
31MP0003938_abnormal_ear_development1.76488711
32MP0009250_abnormal_appendicular_skeleto1.75231526
33MP0003787_abnormal_imprinting1.74895730
34MP0003941_abnormal_skin_development1.71629518
35MP0001986_abnormal_taste_sensitivity1.69071871
36MP0000015_abnormal_ear_pigmentation1.67888811
37MP0001929_abnormal_gametogenesis1.64820782
38MP0001486_abnormal_startle_reflex1.64142916
39MP0003937_abnormal_limbs/digits/tail_de1.63687167
40MP0002272_abnormal_nervous_system1.56137586
41MP0002277_abnormal_respiratory_mucosa1.55570008
42MP0002734_abnormal_mechanical_nocicepti1.55374148
43MP0002249_abnormal_larynx_morphology1.55175290
44MP0001293_anophthalmia1.52662861
45MP0003699_abnormal_female_reproductive1.51966610
46MP0001730_embryonic_growth_arrest1.50968007
47MP0003121_genomic_imprinting1.49187044
48MP0002067_abnormal_sensory_capabilities1.48761828
49MP0009046_muscle_twitch1.48363319
50MP0000026_abnormal_inner_ear1.47788568
51MP0005646_abnormal_pituitary_gland1.46891795
52MP0002177_abnormal_outer_ear1.46637207
53MP0009745_abnormal_behavioral_response1.46629474
54MP0002751_abnormal_autonomic_nervous1.45203388
55MP0003635_abnormal_synaptic_transmissio1.45192282
56MP0004142_abnormal_muscle_tone1.42865470
57MP0000631_abnormal_neuroendocrine_gland1.40017727
58MP0005171_absent_coat_pigmentation1.39354541
59MP0000653_abnormal_sex_gland1.38172555
60MP0002064_seizures1.35387212
61MP0001905_abnormal_dopamine_level1.35096895
62MP0002557_abnormal_social/conspecific_i1.32749001
63MP0002139_abnormal_hepatobiliary_system1.32407881
64MP0008789_abnormal_olfactory_epithelium1.32097820
65MP0002572_abnormal_emotion/affect_behav1.31885936
66MP0001346_abnormal_lacrimal_gland1.31357688
67MP0001672_abnormal_embryogenesis/_devel1.31186186
68MP0005380_embryogenesis_phenotype1.31186186
69MP0001145_abnormal_male_reproductive1.30689762
70MP0003119_abnormal_digestive_system1.30415480
71MP0000049_abnormal_middle_ear1.29706306
72MP0002736_abnormal_nociception_after1.26332010
73MP0000762_abnormal_tongue_morphology1.25327375
74MP0001485_abnormal_pinna_reflex1.24805570
75MP0005423_abnormal_somatic_nervous1.24784654
76MP0002638_abnormal_pupillary_reflex1.23604206
77MP0003755_abnormal_palate_morphology1.22527425
78MP0001963_abnormal_hearing_physiology1.21269507
79MP0001529_abnormal_vocalization1.20231182
80MP0006072_abnormal_retinal_apoptosis1.20143752
81MP0002184_abnormal_innervation1.19839618
82MP0010678_abnormal_skin_adnexa1.19374092
83MP0002752_abnormal_somatic_nervous1.17857229
84MP0010307_abnormal_tumor_latency1.17807747
85MP0002084_abnormal_developmental_patter1.17610011
86MP0002160_abnormal_reproductive_system1.17432258
87MP0002876_abnormal_thyroid_physiology1.17409731
88MP0002161_abnormal_fertility/fecundity1.16738282
89MP0002009_preneoplasia1.15099270
90MP0002063_abnormal_learning/memory/cond1.14990585
91MP0009697_abnormal_copulation1.13957381
92MP0005551_abnormal_eye_electrophysiolog1.13807164
93MP0000350_abnormal_cell_proliferation1.09061757
94MP0003385_abnormal_body_wall1.08443447
95MP0005499_abnormal_olfactory_system1.07385571
96MP0005394_taste/olfaction_phenotype1.07385571
97MP0001919_abnormal_reproductive_system1.07211621
98MP0002735_abnormal_chemical_nociception1.06988745
99MP0008877_abnormal_DNA_methylation1.06483418
100MP0003698_abnormal_male_reproductive1.04471808
101MP0002882_abnormal_neuron_morphology1.04192257
102MP0003567_abnormal_fetal_cardiomyocyte1.03386651
103MP0008260_abnormal_autophagy1.03030317
104MP0001970_abnormal_pain_threshold1.02499566
105MP0001697_abnormal_embryo_size1.01841883
106MP0001440_abnormal_grooming_behavior1.00084326
107MP0002085_abnormal_embryonic_tissue0.98607886
108MP0000579_abnormal_nail_morphology0.97694421
109MP0000427_abnormal_hair_cycle0.96722919
110MP0005248_abnormal_Harderian_gland0.96472511
111MP0002282_abnormal_trachea_morphology0.94686154
112MP0003984_embryonic_growth_retardation0.94199714
113MP0001340_abnormal_eyelid_morphology0.93754035
114MP0002233_abnormal_nose_morphology0.91951851
115MP0005379_endocrine/exocrine_gland_phen0.91439073
116MP0002697_abnormal_eye_size0.91166692
117MP0005410_abnormal_fertilization0.90700598
118MP0002088_abnormal_embryonic_growth/wei0.90667037
119MP0001119_abnormal_female_reproductive0.89574239
120MP0002163_abnormal_gland_morphology0.88978489
121MP0003935_abnormal_craniofacial_develop0.88533301
122MP0005408_hypopigmentation0.88490262
123MP0005174_abnormal_tail_pigmentation0.88369370
124MP0010352_gastrointestinal_tract_polyps0.86870231
125MP0005389_reproductive_system_phenotype0.86579728
126MP0001286_abnormal_eye_development0.86473868
127MP0003950_abnormal_plasma_membrane0.86105735
128MP0001984_abnormal_olfaction0.86028823
129MP0004145_abnormal_muscle_electrophysio0.84784780
130MP0008007_abnormal_cellular_replicative0.83618751
131MP0005195_abnormal_posterior_eye0.83590762
132MP0004859_abnormal_synaptic_plasticity0.83179891
133MP0005187_abnormal_penis_morphology0.82894286
134MP0000751_myopathy0.82860483
135MP0005645_abnormal_hypothalamus_physiol0.82056922
136MP0005647_abnormal_sex_gland0.81361754
137MP0004233_abnormal_muscle_weight0.80458056
138MP0008995_early_reproductive_senescence0.80346259
139MP0004197_abnormal_fetal_growth/weight/0.80040256
140MP0003861_abnormal_nervous_system0.79825514
141MP0003724_increased_susceptibility_to0.79797328
142MP0002080_prenatal_lethality0.79213986
143MP0003868_abnormal_feces_composition0.79211197
144MP0002653_abnormal_ependyma_morphology0.79133099
145MP0002152_abnormal_brain_morphology0.79115596
146MP0002116_abnormal_craniofacial_bone0.77936395
147MP0005360_urolithiasis0.77924293
148MP0002733_abnormal_thermal_nociception0.77301437
149MP0000647_abnormal_sebaceous_gland0.77247605
150MP0004215_abnormal_myocardial_fiber0.76910858
151MP0001177_atelectasis0.76870844
152MP0009780_abnormal_chondrocyte_physiolo0.76851140
153MP0000955_abnormal_spinal_cord0.76427043
154MP0000467_abnormal_esophagus_morphology0.76209246
155MP0005253_abnormal_eye_physiology0.75266481
156MP0000372_irregular_coat_pigmentation0.75008018
157MP0001502_abnormal_circadian_rhythm0.74045406
158MP0005084_abnormal_gallbladder_morpholo0.73741183
159MP0002269_muscular_atrophy0.69588339
160MP0005197_abnormal_uvea_morphology0.69454662
161MP0002092_abnormal_eye_morphology0.69272840
162MP0009672_abnormal_birth_weight0.67290800
163MP0005391_vision/eye_phenotype0.61589031
164MP0000383_abnormal_hair_follicle0.59808375
165MP0002090_abnormal_vision0.58716687
166MP0002111_abnormal_tail_morphology0.58407540
167MP0001324_abnormal_eye_pigmentation0.58361411
168MP0003186_abnormal_redox_activity0.57427318
169MP0005501_abnormal_skin_physiology0.57037526
170MP0002086_abnormal_extraembryonic_tissu0.56825669
171MP0002796_impaired_skin_barrier0.56730384
172MP0003183_abnormal_peptide_metabolism0.56074336

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.98816087
2Facial hemangioma (HP:0000329)3.86326015
3Abnormal ciliary motility (HP:0012262)3.78491065
4Focal motor seizures (HP:0011153)3.70810999
5Papillary thyroid carcinoma (HP:0002895)3.68362432
6Abnormal respiratory motile cilium physiology (HP:0012261)3.52175180
7Absent/shortened dynein arms (HP:0200106)3.44188105
8Dynein arm defect of respiratory motile cilia (HP:0012255)3.44188105
9Volvulus (HP:0002580)3.37488534
10Sex reversal (HP:0012245)3.24136351
11Abnormal sex determination (HP:0012244)3.24136351
12Gonadotropin excess (HP:0000837)3.16667472
13Oligodactyly (hands) (HP:0001180)3.15895016
14Abnormality of abdominal situs (HP:0011620)3.11409037
15Abdominal situs inversus (HP:0003363)3.11409037
16Abnormal gallbladder physiology (HP:0012438)3.02804064
17Cholecystitis (HP:0001082)3.02804064
18Septo-optic dysplasia (HP:0100842)2.98484888
19Abnormal hair whorl (HP:0010721)2.94966266
20Abnormal lung lobation (HP:0002101)2.86133594
21Atonic seizures (HP:0010819)2.86062177
22Abnormality of the septum pellucidum (HP:0007375)2.84784505
23Absent septum pellucidum (HP:0001331)2.82098561
24Abnormal respiratory epithelium morphology (HP:0012253)2.81383145
25Abnormal respiratory motile cilium morphology (HP:0005938)2.81383145
26Febrile seizures (HP:0002373)2.81370309
27Optic nerve hypoplasia (HP:0000609)2.79174698
28Parakeratosis (HP:0001036)2.76110117
29Supernumerary spleens (HP:0009799)2.75337286
30Median cleft lip (HP:0000161)2.73257556
31Medial flaring of the eyebrow (HP:0010747)2.70974695
32Abnormality of the labia minora (HP:0012880)2.70780673
33Optic disc pallor (HP:0000543)2.68542701
34Osteomalacia (HP:0002749)2.64717518
35Attenuation of retinal blood vessels (HP:0007843)2.59638781
36Hypothermia (HP:0002045)2.58500606
37Hyperthyroidism (HP:0000836)2.51883965
38Abnormality of secondary sexual hair (HP:0009888)2.51183218
39Abnormality of the axillary hair (HP:0100134)2.51183218
40Abnormality of chromosome stability (HP:0003220)2.50966485
41Gait imbalance (HP:0002141)2.50598781
42Thyroid carcinoma (HP:0002890)2.50403086
43Nonprogressive disorder (HP:0003680)2.49596763
44Short tibia (HP:0005736)2.47232044
45Sleep apnea (HP:0010535)2.45163104
46Absent speech (HP:0001344)2.42847497
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.39486838
48Congenital primary aphakia (HP:0007707)2.38203367
49Obstructive sleep apnea (HP:0002870)2.37642726
50Aplasia/Hypoplasia of the tibia (HP:0005772)2.36895063
51Thyroid-stimulating hormone excess (HP:0002925)2.36538181
52Meckel diverticulum (HP:0002245)2.34931759
53Esotropia (HP:0000565)2.34639519
54Bifid tongue (HP:0010297)2.34299596
55Atelectasis (HP:0100750)2.33151262
56Oligodactyly (HP:0012165)2.32434784
57Genital tract atresia (HP:0001827)2.32016774
58True hermaphroditism (HP:0010459)2.30345877
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28474266
60Microglossia (HP:0000171)2.27992260
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.27619822
62Broad-based gait (HP:0002136)2.27524745
63Stillbirth (HP:0003826)2.25806875
64Increased nuchal translucency (HP:0010880)2.20902113
65Nephrogenic diabetes insipidus (HP:0009806)2.20724533
66Vaginal atresia (HP:0000148)2.20267195
67Wrist flexion contracture (HP:0001239)2.20195696
68Abnormality of the ileum (HP:0001549)2.19722878
69Proximal tubulopathy (HP:0000114)2.19624553
70Lip pit (HP:0100267)2.17956873
71Intrahepatic cholestasis (HP:0001406)2.16892575
72Azoospermia (HP:0000027)2.16640074
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.14790449
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.14790449
75Epileptic encephalopathy (HP:0200134)2.13100426
76Pancreatic fibrosis (HP:0100732)2.12987402
77Male pseudohermaphroditism (HP:0000037)2.12606150
78Hypoplasia of the fovea (HP:0007750)2.12288309
79Aplasia/Hypoplasia of the fovea (HP:0008060)2.12288309
80Medulloblastoma (HP:0002885)2.12256100
81Rhinitis (HP:0012384)2.12105559
82Abnormality of the preputium (HP:0100587)2.10830847
83Aplasia/Hypoplasia of the lens (HP:0008063)2.10542758
84Chin dimple (HP:0010751)2.09681920
85Ulnar claw (HP:0001178)2.08538466
86Small intestinal stenosis (HP:0012848)2.07790383
87Duodenal stenosis (HP:0100867)2.07790383
88Drooling (HP:0002307)2.07697884
89Excessive salivation (HP:0003781)2.07697884
90Enlarged penis (HP:0000040)2.06099056
91Aplasia/hypoplasia of the uterus (HP:0008684)2.04744945
92Abnormality of the fovea (HP:0000493)2.03812837
93Capillary hemangiomas (HP:0005306)2.03710027
94Adrenal hypoplasia (HP:0000835)2.03188708
95Shoulder girdle muscle weakness (HP:0003547)2.02764516
96Decreased central vision (HP:0007663)2.02335762
97Nephronophthisis (HP:0000090)2.00990762
98Abnormality of incisor morphology (HP:0011063)2.00529410
99Split foot (HP:0001839)1.99833001
100Rhabdomyosarcoma (HP:0002859)1.99173955
101Sensory axonal neuropathy (HP:0003390)1.98330340
102Anomalous pulmonary venous return (HP:0010772)1.97408707
103Midline defect of the nose (HP:0004122)1.97087106
104Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96216588
105Abnormality of the phalanges of the hallux (HP:0010057)1.95745846
106Chromsome breakage (HP:0040012)1.95720504
107Aganglionic megacolon (HP:0002251)1.95400009
108Abnormality of the pulmonary veins (HP:0011718)1.94764796
109Submucous cleft hard palate (HP:0000176)1.93385782
110Heterotopia (HP:0002282)1.93234555
111Ankle contracture (HP:0006466)1.92839850
112Concave nail (HP:0001598)1.92139688
113Premature ovarian failure (HP:0008209)1.89064306
114Poor coordination (HP:0002370)1.88017327
115Progressive inability to walk (HP:0002505)1.87786772
116Hypokinesia (HP:0002375)1.87538375
117Intellectual disability, moderate (HP:0002342)1.87237641
118Hyperventilation (HP:0002883)1.87078798
119Limb hypertonia (HP:0002509)1.87063558
120Limb dystonia (HP:0002451)1.86334093
121Thickened helices (HP:0000391)1.84279481
122Colon cancer (HP:0003003)1.84244912
123Hypophosphatemic rickets (HP:0004912)1.82782986
124Pancreatic cysts (HP:0001737)1.81920061
125Nasolacrimal duct obstruction (HP:0000579)1.81296334
126Abnormality of chromosome segregation (HP:0002916)1.80210245
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.80210137
128Cortical dysplasia (HP:0002539)1.79076200
129Peripheral hypomyelination (HP:0007182)1.78606490
130Urethral obstruction (HP:0000796)1.78512926
131Abnormal biliary tract physiology (HP:0012439)1.77428880
132Bile duct proliferation (HP:0001408)1.77428880
133Bicornuate uterus (HP:0000813)1.76195985
134Absent radius (HP:0003974)1.76014064
135Neoplasm of the oral cavity (HP:0100649)1.75689859
136Abnormality of the renal medulla (HP:0100957)1.74083144
137Abnormality of the duodenum (HP:0002246)1.73799157
138Fair hair (HP:0002286)1.73096216
139Male infertility (HP:0003251)1.72354724
140Overfolded helix (HP:0000396)1.72191605
141Progressive cerebellar ataxia (HP:0002073)1.72034852
142Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.72025707
143Abnormal auditory evoked potentials (HP:0006958)1.69521245
144Nephroblastoma (Wilms tumor) (HP:0002667)1.68507128
145Hydroureter (HP:0000072)1.68471137
146Acute necrotizing encephalopathy (HP:0006965)1.67633165
147Embryonal renal neoplasm (HP:0011794)1.67211951
148Impulsivity (HP:0100710)1.66594412
149Amelogenesis imperfecta (HP:0000705)1.66246106
150Decreased muscle mass (HP:0003199)1.65869293
151Increased serum pyruvate (HP:0003542)1.65542015
152Anterior segment dysgenesis (HP:0007700)1.65322752
153Progressive macrocephaly (HP:0004481)1.65035098
154Astrocytoma (HP:0009592)1.64432094
155Abnormality of the astrocytes (HP:0100707)1.64432094
156Renal dysplasia (HP:0000110)1.64176039
157Patellar aplasia (HP:0006443)1.64101136
158Humeroradial synostosis (HP:0003041)1.63815867
159Synostosis involving the elbow (HP:0003938)1.63815867
160Abnormality of glycolysis (HP:0004366)1.63314417
161Fibular aplasia (HP:0002990)1.62852667
162Abnormality of the lacrimal duct (HP:0011481)1.62572571
163Absent forearm bone (HP:0003953)1.62214998
164Aplasia involving forearm bones (HP:0009822)1.62214998
165Corneal dystrophy (HP:0001131)1.61059935
166Specific learning disability (HP:0001328)1.59935000
167Breast carcinoma (HP:0003002)1.59585871
168Multiple enchondromatosis (HP:0005701)1.57724961
169Abnormality of the labia (HP:0000058)1.56395772
170Abnormal spermatogenesis (HP:0008669)1.56332869
171Embryonal neoplasm (HP:0002898)1.55207399
172Megaloblastic anemia (HP:0001889)1.54904694
173Hypoglycemic coma (HP:0001325)1.54032214
174Posterior subcapsular cataract (HP:0007787)1.53995615
175Clitoromegaly (HP:0000057)1.53445754
176Dysdiadochokinesis (HP:0002075)1.52735202
177Cafe-au-lait spot (HP:0000957)1.51232912
178Truncal obesity (HP:0001956)1.51207787
179Biliary tract neoplasm (HP:0100574)1.50527580
180Infertility (HP:0000789)1.50376265
181Leiomyosarcoma (HP:0100243)1.50105668
182Uterine leiomyosarcoma (HP:0002891)1.50105668
183Maternal diabetes (HP:0009800)1.49348677
184Glioma (HP:0009733)1.48846252
185Termporal pattern (HP:0011008)1.48834485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK8.28140505
2MKNK24.71423884
3MAP3K93.48874498
4TTK3.13064242
5ARAF2.86994371
6TLK12.82537847
7MKNK12.80500488
8EIF2AK32.72760040
9PBK2.51763517
10BUB12.44225404
11TRIM282.37795916
12MET2.36314839
13MUSK2.22871139
14CDC72.20859003
15MAP3K132.15197213
16MAP2K72.13659134
17NEK12.07679688
18PRPF4B2.01231106
19STK241.87525447
20EIF2AK11.82082298
21ERBB31.76449443
22SRPK11.69691731
23PLK11.66136270
24CDK91.64829996
25TSSK61.64006845
26YES11.61371792
27TNIK1.59522067
28BMPR1B1.50338968
29WEE11.47993507
30OXSR11.47009183
31STK391.45917093
32AKT31.45733742
33AURKA1.45609379
34IRAK21.43266839
35IRAK11.41903050
36MAPK131.41341143
37PKN11.38124369
38DYRK21.37656051
39BRAF1.37431269
40BRSK21.32697503
41STK31.30283398
42ERBB41.28966005
43CDK191.28170594
44PHKG21.24534228
45PHKG11.24534228
46MOS1.19255089
47ZAK1.18364646
48BLK1.17922388
49RAF11.16725185
50KSR11.16125959
51PLK21.15729085
52CDK71.10515001
53SGK21.10345827
54FES1.09951508
55SGK2231.09611872
56SGK4941.09611872
57NEK61.09066680
58NEK91.08134815
59BRSK11.07519930
60MAP3K121.06783133
61BMPR21.06222949
62MAP3K41.04172913
63SCYL21.03217264
64PRKD21.02815126
65NEK20.99709501
66MAPK150.99491645
67CDK30.99328648
68NTRK30.97717312
69VRK10.97227241
70PRKCI0.96033386
71LATS10.95446204
72CHEK20.93364040
73STK38L0.93150697
74AURKB0.92860454
75STK160.92607804
76GRK70.92534494
77CAMK2B0.91698932
78BCR0.91547622
79MARK10.89456478
80KSR20.86697491
81MST1R0.86526317
82DYRK1A0.86236869
83FGR0.85986361
84IRAK40.85128449
85CAMK2A0.83947579
86CHEK10.83227082
87TNK20.83184023
88FER0.82163412
89ADRBK20.80787544
90PNCK0.78740460
91UHMK10.78408688
92ATM0.75604014
93GRK10.74950256
94PDK20.74666577
95ATR0.74342151
96DMPK0.72636682
97MAP3K60.71989324
98MST40.71137792
99CSNK1G10.70643647
100NLK0.69201162
101ACVR1B0.67822638
102EPHA40.67783442
103IRAK30.66158000
104OBSCN0.65812587
105CCNB10.65542973
106PLK40.64935422
107CDK20.63389704
108CDK10.63338941
109MAP3K80.62577728
110LATS20.59320270
111PLK30.58626973
112CSNK1E0.58499624
113RPS6KB20.57845595
114PRKCE0.57643378
115CLK10.57340807
116MAPKAPK50.56413056
117LIMK10.55512316
118PTK20.53989133
119NTRK20.53884633
120MAP2K40.53471948
121FRK0.51981557
122WNK40.51352972
123STK380.49655348
124CDK180.49462288
125CSNK1G30.46801522
126AKT20.45395315
127PRKG10.44931672
128CDK140.44890872
129CDK60.44729890
130CAMK2D0.43840545
131CDK150.43559902
132PAK40.43354044
133PRKD30.43345248
134ROCK20.43132383
135EEF2K0.43050667
136MINK10.43046319
137MAP4K20.42752228
138STK110.42195869
139CDK11A0.42163177
140CSNK1D0.41625599
141WNK30.41439531
142PRKAA20.41272978
143TGFBR10.39620871
144HIPK20.39445249
145EIF2AK20.39347948
146CAMK2G0.38764425
147DYRK30.38195968
148INSRR0.37329349
149CSNK1A1L0.36458523
150CDK80.35525929
151EPHB20.35399538
152NME10.34688034
153RPS6KA50.34512015
154MAP3K140.34115823
155GRK50.33072809
156TAOK30.32950503
157MAPK100.31708641
158CSNK1G20.31408115
159NUAK10.30542213
160PRKACA0.30157291
161SGK10.30045481
162CDK50.28505422
163PIK3CA0.28494671

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.38029621
2Mismatch repair_Homo sapiens_hsa034303.33984125
3Nicotine addiction_Homo sapiens_hsa050333.33306164
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.81349310
5Ether lipid metabolism_Homo sapiens_hsa005652.46934168
6DNA replication_Homo sapiens_hsa030302.45169553
7Nucleotide excision repair_Homo sapiens_hsa034202.34796031
8Basal transcription factors_Homo sapiens_hsa030222.14419391
9Base excision repair_Homo sapiens_hsa034102.13965433
10* RNA transport_Homo sapiens_hsa030132.13918505
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.11688103
12Axon guidance_Homo sapiens_hsa043602.05832603
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03440109
14Serotonergic synapse_Homo sapiens_hsa047262.02983683
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02457277
16Long-term depression_Homo sapiens_hsa047302.01714260
17Fanconi anemia pathway_Homo sapiens_hsa034601.98820633
18Cysteine and methionine metabolism_Homo sapiens_hsa002701.95020376
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93390874
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93319959
21Taste transduction_Homo sapiens_hsa047421.90072674
22Protein export_Homo sapiens_hsa030601.88557962
23Folate biosynthesis_Homo sapiens_hsa007901.83809182
24Sphingolipid metabolism_Homo sapiens_hsa006001.83135875
25Oxidative phosphorylation_Homo sapiens_hsa001901.82398881
26Propanoate metabolism_Homo sapiens_hsa006401.76990668
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75897196
28Glutamatergic synapse_Homo sapiens_hsa047241.69137957
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.67934565
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63575700
31Caffeine metabolism_Homo sapiens_hsa002321.60213362
32Morphine addiction_Homo sapiens_hsa050321.57495191
33Proteasome_Homo sapiens_hsa030501.56694208
34GABAergic synapse_Homo sapiens_hsa047271.53867096
35mRNA surveillance pathway_Homo sapiens_hsa030151.53603035
36RNA polymerase_Homo sapiens_hsa030201.50144748
37Fatty acid elongation_Homo sapiens_hsa000621.44223313
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.41061055
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.41054540
40Pyruvate metabolism_Homo sapiens_hsa006201.38371082
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.38228211
42Linoleic acid metabolism_Homo sapiens_hsa005911.34548452
43p53 signaling pathway_Homo sapiens_hsa041151.32130784
44Huntingtons disease_Homo sapiens_hsa050161.28241839
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27439197
46Collecting duct acid secretion_Homo sapiens_hsa049661.26110139
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.25040972
48Arachidonic acid metabolism_Homo sapiens_hsa005901.24332468
49Wnt signaling pathway_Homo sapiens_hsa043101.23178986
50Melanogenesis_Homo sapiens_hsa049161.23006283
51Amphetamine addiction_Homo sapiens_hsa050311.15098128
52Homologous recombination_Homo sapiens_hsa034401.14418765
53Ovarian steroidogenesis_Homo sapiens_hsa049131.14312650
54Dopaminergic synapse_Homo sapiens_hsa047281.12762062
55Ras signaling pathway_Homo sapiens_hsa040141.09219633
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06271168
57Melanoma_Homo sapiens_hsa052181.05256183
58Alzheimers disease_Homo sapiens_hsa050101.04790897
59ErbB signaling pathway_Homo sapiens_hsa040121.03001310
60Synaptic vesicle cycle_Homo sapiens_hsa047211.02638769
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02583540
62Cocaine addiction_Homo sapiens_hsa050301.01040615
63Long-term potentiation_Homo sapiens_hsa047201.00545949
64Carbon metabolism_Homo sapiens_hsa012000.99986109
65Circadian entrainment_Homo sapiens_hsa047130.99903568
66Circadian rhythm_Homo sapiens_hsa047100.99497598
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98934075
68Biosynthesis of amino acids_Homo sapiens_hsa012300.98732042
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98468359
70Basal cell carcinoma_Homo sapiens_hsa052170.93452968
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92959207
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91297845
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90831030
74Hippo signaling pathway_Homo sapiens_hsa043900.90744672
75RNA degradation_Homo sapiens_hsa030180.89095088
76Olfactory transduction_Homo sapiens_hsa047400.87874724
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87720650
78Vitamin B6 metabolism_Homo sapiens_hsa007500.87084762
79Parkinsons disease_Homo sapiens_hsa050120.85273322
80GnRH signaling pathway_Homo sapiens_hsa049120.84235721
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83121829
82Renal cell carcinoma_Homo sapiens_hsa052110.82090079
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82039886
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81395528
85Autoimmune thyroid disease_Homo sapiens_hsa053200.81307383
86Hedgehog signaling pathway_Homo sapiens_hsa043400.81163807
87Calcium signaling pathway_Homo sapiens_hsa040200.79537960
88Arginine and proline metabolism_Homo sapiens_hsa003300.79239022
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.76374316
90Prostate cancer_Homo sapiens_hsa052150.76305839
91Cholinergic synapse_Homo sapiens_hsa047250.75126840
92Choline metabolism in cancer_Homo sapiens_hsa052310.74099218
93One carbon pool by folate_Homo sapiens_hsa006700.73885368
94Renin secretion_Homo sapiens_hsa049240.73603140
95Adherens junction_Homo sapiens_hsa045200.73140856
96Vibrio cholerae infection_Homo sapiens_hsa051100.72797924
97Rheumatoid arthritis_Homo sapiens_hsa053230.71764676
98Spliceosome_Homo sapiens_hsa030400.71525534
99MAPK signaling pathway_Homo sapiens_hsa040100.71065558
100Pyrimidine metabolism_Homo sapiens_hsa002400.70695891
101Maturity onset diabetes of the young_Homo sapiens_hsa049500.69307916
102cAMP signaling pathway_Homo sapiens_hsa040240.67845644
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67760142
104Thyroid cancer_Homo sapiens_hsa052160.67492932
105Salivary secretion_Homo sapiens_hsa049700.67290335
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.66439860
107Insulin secretion_Homo sapiens_hsa049110.65555622
108Arginine biosynthesis_Homo sapiens_hsa002200.65546558
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65431335
110Steroid biosynthesis_Homo sapiens_hsa001000.64255044
111Other glycan degradation_Homo sapiens_hsa005110.62640557
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62378676
113Oxytocin signaling pathway_Homo sapiens_hsa049210.61600972
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60791069
115Dorso-ventral axis formation_Homo sapiens_hsa043200.59608914
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56679148
117Gap junction_Homo sapiens_hsa045400.56492403
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54038560
119Selenocompound metabolism_Homo sapiens_hsa004500.53401004
120Cell cycle_Homo sapiens_hsa041100.49185225
121Alcoholism_Homo sapiens_hsa050340.48113754
122Non-homologous end-joining_Homo sapiens_hsa034500.47961911
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47313294
124Phagosome_Homo sapiens_hsa041450.46982252
125MicroRNAs in cancer_Homo sapiens_hsa052060.46938199
126Fatty acid metabolism_Homo sapiens_hsa012120.46251250
127Oocyte meiosis_Homo sapiens_hsa041140.45780005
128TGF-beta signaling pathway_Homo sapiens_hsa043500.45570113
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44438323
130Purine metabolism_Homo sapiens_hsa002300.42948698
131Glutathione metabolism_Homo sapiens_hsa004800.42765394
132Inositol phosphate metabolism_Homo sapiens_hsa005620.41946705
133Butanoate metabolism_Homo sapiens_hsa006500.41542131
134Small cell lung cancer_Homo sapiens_hsa052220.41475733
135Pentose phosphate pathway_Homo sapiens_hsa000300.41063847
136Metabolic pathways_Homo sapiens_hsa011000.40993922
137Histidine metabolism_Homo sapiens_hsa003400.40773366
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38771470
139Cardiac muscle contraction_Homo sapiens_hsa042600.37691243
140Endometrial cancer_Homo sapiens_hsa052130.37633924
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37232546
142Retinol metabolism_Homo sapiens_hsa008300.36706518
143Gastric acid secretion_Homo sapiens_hsa049710.35848367
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35329388
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.34176768
146N-Glycan biosynthesis_Homo sapiens_hsa005100.32716172
147Tight junction_Homo sapiens_hsa045300.31042584
148beta-Alanine metabolism_Homo sapiens_hsa004100.30125964
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.29247072
150Colorectal cancer_Homo sapiens_hsa052100.24313089
151AMPK signaling pathway_Homo sapiens_hsa041520.21842124
152Viral carcinogenesis_Homo sapiens_hsa052030.21483499
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.21096030
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.19550419
155mTOR signaling pathway_Homo sapiens_hsa041500.18638734

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