PAIP1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intra-S DNA damage checkpoint (GO:0031573)7.58769730
2regulation of transforming growth factor beta2 production (GO:0032909)7.42741968
3positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021106.38083554
4mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)6.38083554
5negative regulation of retinoic acid receptor signaling pathway (GO:0048387)6.31622512
6regulation of RIG-I signaling pathway (GO:0039535)6.15293914
7regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)5.63034940
8spliceosomal tri-snRNP complex assembly (GO:0000244)5.56829377
9regulation of retinoic acid receptor signaling pathway (GO:0048385)5.43728885
10positive regulation of mRNA catabolic process (GO:0061014)5.33073211
11regulation of interferon-alpha production (GO:0032647)5.23882540
12positive regulation of interferon-alpha production (GO:0032727)5.22507174
13sphingosine metabolic process (GO:0006670)5.12537394
14protein-chromophore linkage (GO:0018298)4.89216820
15macrophage differentiation (GO:0030225)4.73113257
16DNA methylation involved in gamete generation (GO:0043046)4.70595178
17diol metabolic process (GO:0034311)4.69139936
18positive regulation of interferon-beta production (GO:0032728)4.66115397
19UDP-N-acetylglucosamine metabolic process (GO:0006047)4.61738988
20positive regulation of mitochondrial membrane permeability (GO:0035794)4.57727628
21necroptotic process (GO:0070266)4.51500375
22positive regulation of developmental pigmentation (GO:0048087)4.51463758
23regulation of mRNA catabolic process (GO:0061013)4.44004338
24regulation of nuclear cell cycle DNA replication (GO:0033262)4.41766879
25activated T cell proliferation (GO:0050798)4.30667300
26programmed necrotic cell death (GO:0097300)4.17828466
27sphingoid metabolic process (GO:0046519)4.17493888
28positive regulation of toll-like receptor signaling pathway (GO:0034123)4.04637959
29negative regulation of viral genome replication (GO:0045071)4.03431739
30necrotic cell death (GO:0070265)4.00012415
31DNA deamination (GO:0045006)3.99918044
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.98511121
33piRNA metabolic process (GO:0034587)3.97399891
34ribosome assembly (GO:0042255)3.95688245
35G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.78872765
36negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.74737450
37positive regulation of mRNA metabolic process (GO:1903313)3.57801221
38regulation of interferon-beta production (GO:0032648)3.53749965
39positive regulation of transforming growth factor beta production (GO:0071636)3.52811584
40positive regulation of translational initiation (GO:0045948)3.47463999
41nucleotide-sugar biosynthetic process (GO:0009226)3.42759210
42regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.42314270
43regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.41717812
44attachment of spindle microtubules to kinetochore (GO:0008608)3.20244668
45sulfate transmembrane transport (GO:1902358)3.20042505
46purinergic nucleotide receptor signaling pathway (GO:0035590)3.18048128
47regulation of viral genome replication (GO:0045069)3.17776473
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17303244
49regulation of meiosis I (GO:0060631)3.15963363
50negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.15313260
51mitotic sister chromatid segregation (GO:0000070)3.14431658
52genitalia morphogenesis (GO:0035112)3.14425017
53negative regulation of cell cycle arrest (GO:0071157)3.12911055
54reciprocal meiotic recombination (GO:0007131)3.12141249
55reciprocal DNA recombination (GO:0035825)3.12141249
56transcription elongation from RNA polymerase I promoter (GO:0006362)3.06941314
57transcription initiation from RNA polymerase I promoter (GO:0006361)3.06276540
58meiotic chromosome segregation (GO:0045132)3.05418091
59prenylation (GO:0097354)3.05196468
60protein prenylation (GO:0018342)3.05196468
61termination of RNA polymerase I transcription (GO:0006363)2.98658672
62transcription from mitochondrial promoter (GO:0006390)2.95766451
63response to interferon-beta (GO:0035456)2.95438230
64cellular response to type I interferon (GO:0071357)2.89565477
65type I interferon signaling pathway (GO:0060337)2.89565477
66regulation of B cell receptor signaling pathway (GO:0050855)2.86399085
67response to type I interferon (GO:0034340)2.83893698
68intestinal epithelial cell development (GO:0060576)2.82308502
69cellular response to interleukin-15 (GO:0071350)2.82003567
70cellular response to arsenic-containing substance (GO:0071243)2.80860508
71platelet dense granule organization (GO:0060155)2.80548185
72sister chromatid segregation (GO:0000819)2.80106013
73sulfate transport (GO:0008272)2.79115814
74positive regulation of response to biotic stimulus (GO:0002833)2.77822500
75response to interleukin-15 (GO:0070672)2.76709298
76regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.75525344
77amino acid salvage (GO:0043102)2.75065013
78L-methionine salvage (GO:0071267)2.75065013
79L-methionine biosynthetic process (GO:0071265)2.75065013
80regulation of alkaline phosphatase activity (GO:0010692)2.74377517
81protein localization to cell surface (GO:0034394)2.73533606
82negative regulation of glycoprotein biosynthetic process (GO:0010561)2.73373835
83lipopolysaccharide biosynthetic process (GO:0009103)2.72378900
84dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.70374310
85methionine biosynthetic process (GO:0009086)2.69326603
86pore complex assembly (GO:0046931)2.68844729
87secondary metabolite biosynthetic process (GO:0044550)2.68782316
88positive regulation of uterine smooth muscle contraction (GO:0070474)2.67022213
89RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64861962
90regulation of helicase activity (GO:0051095)2.64289377
91positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.63487837
92cytidine deamination (GO:0009972)2.60743867
93cytidine metabolic process (GO:0046087)2.60743867
94cytidine catabolic process (GO:0006216)2.60743867
95negative regulation of viral process (GO:0048525)2.57537876
96positive regulation of cell cycle G1/S phase transition (GO:1902808)2.57391377
97female gonad development (GO:0008585)2.56290998
98tyrosine metabolic process (GO:0006570)2.55829297
99regulation of translation in response to stress (GO:0043555)2.55791997
100regulation of protein glycosylation (GO:0060049)2.54726417

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.72069853
2SMAD_19615063_ChIP-ChIP_OVARY_Human4.06935386
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58138733
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.26124489
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.18158267
6GATA1_22025678_ChIP-Seq_K562_Human3.14507462
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.97464965
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.96759596
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.69397869
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.50055664
11IGF1R_20145208_ChIP-Seq_DFB_Human2.49449244
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.46856839
13NOTCH1_21737748_ChIP-Seq_TLL_Human2.34649134
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.17705640
15VDR_22108803_ChIP-Seq_LS180_Human1.99437084
16NFE2_27457419_Chip-Seq_LIVER_Mouse1.87340254
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.86633032
18EZH2_27294783_Chip-Seq_NPCs_Mouse1.78611097
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.77577897
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73107982
21GBX2_23144817_ChIP-Seq_PC3_Human1.72351506
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72057906
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64552304
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62739358
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61632250
26VDR_23849224_ChIP-Seq_CD4+_Human1.57616828
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.50307851
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50233260
29ZNF274_21170338_ChIP-Seq_K562_Hela1.48284857
30CRX_20693478_ChIP-Seq_RETINA_Mouse1.47901630
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45541281
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45417033
33EWS_26573619_Chip-Seq_HEK293_Human1.44147837
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.42680415
35ELK1_19687146_ChIP-ChIP_HELA_Human1.42435030
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.41104231
37CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39874238
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.39480544
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39256727
40GATA3_26560356_Chip-Seq_TH2_Human1.38863570
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37973222
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36635976
43PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35762216
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34655532
45OCT4_21477851_ChIP-Seq_ESCs_Mouse1.34565377
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33518855
47SMRT_27268052_Chip-Seq_Bcells_Human1.32753244
48TCF4_22108803_ChIP-Seq_LS180_Human1.32188906
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31708642
50CDX2_22108803_ChIP-Seq_LS180_Human1.30217616
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.29168759
52OCT4_18555785_Chip-Seq_ESCs_Mouse1.28977577
53P300_19829295_ChIP-Seq_ESCs_Human1.28890441
54P53_22387025_ChIP-Seq_ESCs_Mouse1.27793236
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24297233
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.22983864
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22983864
58AR_21572438_ChIP-Seq_LNCaP_Human1.22000551
59STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21360887
60MYB_26560356_Chip-Seq_TH2_Human1.20087218
61NANOG_19829295_ChIP-Seq_ESCs_Human1.19919454
62SOX2_19829295_ChIP-Seq_ESCs_Human1.19919454
63FOXP3_21729870_ChIP-Seq_TREG_Human1.19636298
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19547202
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18433686
66MYB_26560356_Chip-Seq_TH1_Human1.18426087
67STAT3_23295773_ChIP-Seq_U87_Human1.18370242
68ER_23166858_ChIP-Seq_MCF-7_Human1.16573074
69P300_18555785_Chip-Seq_ESCs_Mouse1.16394389
70SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16023382
71HOXB7_26014856_ChIP-Seq_BT474_Human1.15873118
72SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14591500
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.14469528
74PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13797032
75EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12956011
76SMAD4_21799915_ChIP-Seq_A2780_Human1.10771475
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.10605113
78TCF4_23295773_ChIP-Seq_U87_Human1.08786133
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.08658593
80BCAT_22108803_ChIP-Seq_LS180_Human1.06789282
81CTCF_18555785_Chip-Seq_ESCs_Mouse1.06763932
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06718996
83FUS_26573619_Chip-Seq_HEK293_Human1.06691118
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06163482
85ZFX_18555785_Chip-Seq_ESCs_Mouse1.05250135
86CMYC_18555785_Chip-Seq_ESCs_Mouse1.05203292
87RUNX_20019798_ChIP-Seq_JUKART_Human1.03700072
88NMYC_18555785_Chip-Seq_ESCs_Mouse1.01510824
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01112805
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99704921
91EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98892720
92EGR1_19032775_ChIP-ChIP_M12_Human0.98351021
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98007133
94GATA3_26560356_Chip-Seq_TH1_Human0.97497264
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.97128663
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.97046178
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96266876
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.94372204
99PU1_27457419_Chip-Seq_LIVER_Mouse0.94181788
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94046618

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.18614277
2MP0005171_absent_coat_pigmentation5.16581745
3MP0002837_dystrophic_cardiac_calcinosis4.33380841
4MP0000372_irregular_coat_pigmentation4.19788277
5MP0002653_abnormal_ependyma_morphology3.90029082
6MP0005075_abnormal_melanosome_morpholog3.15144607
7MP0003890_abnormal_embryonic-extraembry2.94050006
8MP0004381_abnormal_hair_follicle2.87738347
9MP0005451_abnormal_body_composition2.58421053
10MP0003763_abnormal_thymus_physiology2.57204960
11MP0001835_abnormal_antigen_presentation2.49818823
12MP0000427_abnormal_hair_cycle2.30378941
13MP0002166_altered_tumor_susceptibility2.29104567
14MP0005671_abnormal_response_to2.28688729
15MP0009785_altered_susceptibility_to2.26305127
16MP0000569_abnormal_digit_pigmentation2.21805668
17MP0005076_abnormal_cell_differentiation2.07887828
18MP0008057_abnormal_DNA_replication1.98061360
19MP0001800_abnormal_humoral_immune1.94818755
20MP0002006_tumorigenesis1.94251267
21MP0002638_abnormal_pupillary_reflex1.86016130
22MP0005670_abnormal_white_adipose1.83214607
23MP0002102_abnormal_ear_morphology1.80489213
24MP0003646_muscle_fatigue1.80418196
25MP0009115_abnormal_fat_cell1.77144708
26MP0003693_abnormal_embryo_hatching1.76454136
27MP0003045_fibrosis1.71795370
28MP0002938_white_spotting1.67640999
29MP0002095_abnormal_skin_pigmentation1.66574941
30MP0005408_hypopigmentation1.58218801
31MP0010094_abnormal_chromosome_stability1.57734257
32MP0002723_abnormal_immune_serum1.56964115
33MP0000015_abnormal_ear_pigmentation1.55003561
34MP0000371_diluted_coat_color1.53488149
35MP0002148_abnormal_hypersensitivity_rea1.44850731
36MP0001324_abnormal_eye_pigmentation1.39492971
37MP0005025_abnormal_response_to1.39216747
38MP0002452_abnormal_antigen_presenting1.36321666
39MP0001851_eye_inflammation1.34535711
40MP0002075_abnormal_coat/hair_pigmentati1.31010642
41MP0005387_immune_system_phenotype1.28922942
42MP0001790_abnormal_immune_system1.28922942
43MP0005174_abnormal_tail_pigmentation1.27854756
44MP0002138_abnormal_hepatobiliary_system1.22516166
45MP0002420_abnormal_adaptive_immunity1.20687310
46MP0008877_abnormal_DNA_methylation1.18581818
47MP0005000_abnormal_immune_tolerance1.17149559
48MP0005377_hearing/vestibular/ear_phenot1.16383129
49MP0003878_abnormal_ear_physiology1.16383129
50MP0001819_abnormal_immune_cell1.16079289
51MP0003950_abnormal_plasma_membrane1.13166712
52MP0002398_abnormal_bone_marrow1.11955935
53MP0009764_decreased_sensitivity_to1.08382206
54MP0000689_abnormal_spleen_morphology1.07889113
55MP0000716_abnormal_immune_system1.06910871
56MP0009333_abnormal_splenocyte_physiolog1.06101822
57MP0001764_abnormal_homeostasis1.05451672
58MP0005389_reproductive_system_phenotype1.04773027
59MP0003195_calcinosis1.01089384
60MP0001845_abnormal_inflammatory_respons0.98263563
61MP0001666_abnormal_nutrient_absorption0.91938660
62MP0002332_abnormal_exercise_endurance0.87264963
63MP0003137_abnormal_impulse_conducting0.86921116
64MP0001186_pigmentation_phenotype0.86789345
65MP0008569_lethality_at_weaning0.84887573
66MP0010155_abnormal_intestine_physiology0.84380679
67MP0002722_abnormal_immune_system0.84173717
68MP0001919_abnormal_reproductive_system0.83568683
69MP0004484_altered_response_of0.82817050
70MP0003943_abnormal_hepatobiliary_system0.82611113
71MP0005551_abnormal_eye_electrophysiolog0.82211289
72MP0010307_abnormal_tumor_latency0.81523690
73MP0002160_abnormal_reproductive_system0.79714239
74MP0004957_abnormal_blastocyst_morpholog0.77430688
75MP0002429_abnormal_blood_cell0.76757723
76MP0002168_other_aberrant_phenotype0.72294422
77MP0008469_abnormal_protein_level0.71943622
78MP0005253_abnormal_eye_physiology0.70522700
79MP0003077_abnormal_cell_cycle0.70483165
80MP0000703_abnormal_thymus_morphology0.69157083
81MP0003866_abnormal_defecation0.68363741
82MP0001929_abnormal_gametogenesis0.67337841
83MP0002396_abnormal_hematopoietic_system0.65276519
84MP0003300_gastrointestinal_ulcer0.64587994
85MP0005085_abnormal_gallbladder_physiolo0.64443924
86MP0004885_abnormal_endolymph0.63827788
87MP0000367_abnormal_coat/_hair0.63437624
88MP0002210_abnormal_sex_determination0.61671671
89MP0002971_abnormal_brown_adipose0.61191713
90MP0008932_abnormal_embryonic_tissue0.59963696
91MP0008872_abnormal_physiological_respon0.58570157
92MP0000383_abnormal_hair_follicle0.57171786
93MP0000858_altered_metastatic_potential0.55729643
94MP0009763_increased_sensitivity_to0.55553567
95MP0010386_abnormal_urinary_bladder0.55317030
96MP0002269_muscular_atrophy0.53806298
97MP0001191_abnormal_skin_condition0.53746648
98MP0003787_abnormal_imprinting0.53581247
99MP0001501_abnormal_sleep_pattern0.53450573
100MP0002419_abnormal_innate_immunity0.53302513

Predicted human phenotypes

RankGene SetZ-score
1Progressive inability to walk (HP:0002505)4.97284353
2Autoimmune hemolytic anemia (HP:0001890)4.46984153
3Neoplasm of the adrenal cortex (HP:0100641)4.36775172
4Aplasia/Hypoplasia of the uvula (HP:0010293)4.03180894
5Birth length less than 3rd percentile (HP:0003561)3.86080945
6Amelogenesis imperfecta (HP:0000705)3.66951218
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.60623002
8Parakeratosis (HP:0001036)3.46090343
9Chronic diarrhea (HP:0002028)3.38316736
10Optic neuritis (HP:0100653)3.27896902
11Retrobulbar optic neuritis (HP:0100654)3.27896902
12Albinism (HP:0001022)3.16542294
13Chromsome breakage (HP:0040012)3.16035785
14Focal motor seizures (HP:0011153)3.15541114
15Clubbing of toes (HP:0100760)3.12970737
16Pancreatic cysts (HP:0001737)3.00565445
17Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.89342391
18Meckel diverticulum (HP:0002245)2.84838354
19Abnormality of chromosome stability (HP:0003220)2.84279673
20Abnormality of the ileum (HP:0001549)2.82376493
21Gastrointestinal stroma tumor (HP:0100723)2.78071284
22Gangrene (HP:0100758)2.76034485
23Hypoproteinemia (HP:0003075)2.75195773
24IgG deficiency (HP:0004315)2.74072802
25Orchitis (HP:0100796)2.70051016
26Anterior segment dysgenesis (HP:0007700)2.67769894
27Neoplasm of the adrenal gland (HP:0100631)2.65402719
28Vasculitis (HP:0002633)2.65064321
29Metaphyseal dysplasia (HP:0100255)2.62279043
30Enlarged epiphyses (HP:0010580)2.59312914
31Hemoptysis (HP:0002105)2.55646263
32Inability to walk (HP:0002540)2.53864853
33Polyneuropathy (HP:0001271)2.50683268
34Arterial thrombosis (HP:0004420)2.48936004
35Colon cancer (HP:0003003)2.47949439
36Iris hypopigmentation (HP:0007730)2.41842205
37Abnormality of the preputium (HP:0100587)2.39638940
38Pulmonary infiltrates (HP:0002113)2.35716235
39Ocular albinism (HP:0001107)2.27574673
40Abnormality of B cell number (HP:0010975)2.26557133
41Congenital stationary night blindness (HP:0007642)2.24776884
42Abnormality of the renal cortex (HP:0011035)2.21610124
43Myelodysplasia (HP:0002863)2.18595276
44Stomatitis (HP:0010280)2.17324319
45Recurrent sinusitis (HP:0011108)2.16917920
46Hematochezia (HP:0002573)2.14730433
47Volvulus (HP:0002580)2.10801914
48Myositis (HP:0100614)2.10033393
49Recurrent bronchitis (HP:0002837)2.09556722
50Pancreatic fibrosis (HP:0100732)2.07071948
513-Methylglutaconic aciduria (HP:0003535)2.04963668
52Small intestinal stenosis (HP:0012848)2.03733818
53Duodenal stenosis (HP:0100867)2.03733818
54Thyroiditis (HP:0100646)2.03489703
55Lymphoma (HP:0002665)2.01311803
56Bilateral sensorineural hearing impairment (HP:0008619)2.00541190
57Macular degeneration (HP:0000608)1.99892188
58Dialeptic seizures (HP:0011146)1.98028583
59Glioma (HP:0009733)1.96981498
60Agammaglobulinemia (HP:0004432)1.95864704
61True hermaphroditism (HP:0010459)1.95491413
62Aplastic anemia (HP:0001915)1.95202765
63Pulmonary embolism (HP:0002204)1.94216704
64Abnormality of the prostate (HP:0008775)1.93303487
65Type I transferrin isoform profile (HP:0003642)1.92052849
66Proximal amyotrophy (HP:0007126)1.91090945
67Keratoconjunctivitis sicca (HP:0001097)1.91041931
68Sloping forehead (HP:0000340)1.90646453
69Anorexia (HP:0002039)1.87258601
70Glucose intolerance (HP:0000833)1.83233669
71Increased IgM level (HP:0003496)1.82890580
72Neoplasm of the colon (HP:0100273)1.82577785
73Joint swelling (HP:0001386)1.82042520
74Fair hair (HP:0002286)1.80809930
75Breast carcinoma (HP:0003002)1.80578541
76Erythroderma (HP:0001019)1.78270694
77Lymphopenia (HP:0001888)1.78204328
78Melanoma (HP:0002861)1.76109065
79Neonatal respiratory distress (HP:0002643)1.75297944
80Abnormality of T cell number (HP:0011839)1.73190121
81Abnormality of the duodenum (HP:0002246)1.72896131
82Hypothermia (HP:0002045)1.72594069
83Abnormality of the line of Schwalbe (HP:0008048)1.72255703
84Abnormality of the carotid arteries (HP:0005344)1.72159499
85Disproportionate short-trunk short stature (HP:0003521)1.71460141
86Stomach cancer (HP:0012126)1.71397744
87Prominent nose (HP:0000448)1.70516076
88Hamartoma of the eye (HP:0010568)1.68736681
89Acanthocytosis (HP:0001927)1.68393735
90Aplasia/Hypoplasia of the fovea (HP:0008060)1.67996537
91Hypoplasia of the fovea (HP:0007750)1.67996537
92Chronic sinusitis (HP:0011109)1.67392937
93Meningioma (HP:0002858)1.66674257
94Gaze-evoked nystagmus (HP:0000640)1.65030640
95Keratoconjunctivitis (HP:0001096)1.64788611
96Abnormality of cells of the lymphoid lineage (HP:0012140)1.64235520
97Abnormality of the renal medulla (HP:0100957)1.63946979
98B lymphocytopenia (HP:0010976)1.63109263
99Hip dysplasia (HP:0001385)1.61198928
100Generalized hypopigmentation (HP:0007513)1.60659568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK14.96778924
2LATS14.69690670
3VRK14.01209996
4FRK3.39250583
5ACVR1B3.34578609
6STK38L3.22465901
7BMPR1B3.07134644
8TRIM282.89228698
9LATS22.62992368
10ZAK2.58476069
11PDK22.48724518
12TNIK2.32775217
13IRAK32.22939942
14MELK2.19895263
15PLK32.12252184
16SIK31.98650347
17MST41.89982153
18NLK1.89672341
19BMPR21.85799308
20BUB11.80204138
21TYRO31.73540207
22EIF2AK31.72712488
23CDK81.71668283
24TAOK31.58806808
25PIK3CA1.50996749
26TGFBR21.50355284
27TRPM71.37128902
28WEE11.36478095
29FES1.32075173
30TXK1.30454318
31STK31.29189561
32TAF11.28700726
33PRPF4B1.25107595
34JAK11.24707656
35JAK31.22961792
36PIM11.10925834
37TYK20.92886705
38MAP2K60.88131044
39TGFBR10.88081978
40EIF2AK10.83943302
41ADRBK20.79307688
42IKBKE0.75755002
43NUAK10.74415430
44OXSR10.72069384
45STK100.70410276
46MKNK20.70176915
47CDK30.68033140
48PRKCE0.67959876
49EIF2AK20.67907464
50MARK30.66098744
51ERBB30.64845806
52IKBKB0.62079599
53PDPK10.59384721
54NEK60.58473104
55IRAK10.57969426
56MAP2K20.56738065
57KIT0.56403962
58AKT30.56212686
59PRKCI0.54925324
60CHEK20.53236362
61BTK0.50656937
62GRK10.50350150
63GRK70.49675545
64WNK30.47897434
65TBK10.47039573
66TEC0.45706991
67BCR0.44220442
68CHUK0.43706871
69IGF1R0.42834035
70CSNK1D0.42001065
71PLK20.41769552
72HCK0.40031834
73ADRBK10.39761849
74NEK20.39617307
75MKNK10.39107562
76PRKD30.39086297
77MAPK70.38351057
78ITK0.38290385
79LYN0.37944510
80PRKD10.37265229
81ABL10.37216701
82PLK10.35614359
83VRK20.35608049
84IRAK40.35084413
85TTK0.33645210
86FGFR40.33289811
87PLK40.33225243
88FGFR30.32830999
89JAK20.32744275
90LCK0.31635494
91CSK0.31385119
92PDK10.31039712
93ERBB40.29245396
94CSNK1G10.29244477
95STK390.29128240
96TLK10.28388798
97ATM0.26652570
98STK110.26617563
99FER0.26054089
100PKN20.25968486

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.46177038
2Homologous recombination_Homo sapiens_hsa034403.37127104
3Mismatch repair_Homo sapiens_hsa034303.30783949
4Fanconi anemia pathway_Homo sapiens_hsa034602.72089305
5One carbon pool by folate_Homo sapiens_hsa006702.64584874
6Dorso-ventral axis formation_Homo sapiens_hsa043202.40982735
7Nucleotide excision repair_Homo sapiens_hsa034202.30754948
8Selenocompound metabolism_Homo sapiens_hsa004502.28522756
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26140606
10Graft-versus-host disease_Homo sapiens_hsa053322.23690512
11Measles_Homo sapiens_hsa051622.18088911
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.17485180
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07320681
14Phototransduction_Homo sapiens_hsa047442.04400542
15Primary immunodeficiency_Homo sapiens_hsa053401.84142210
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.82495896
17Asthma_Homo sapiens_hsa053101.79338340
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.77477249
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76640032
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72921621
21Hepatitis B_Homo sapiens_hsa051611.68924136
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68590800
23Allograft rejection_Homo sapiens_hsa053301.65498760
24Autoimmune thyroid disease_Homo sapiens_hsa053201.57431685
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55946230
26Viral myocarditis_Homo sapiens_hsa054161.48859138
27Proteasome_Homo sapiens_hsa030501.48513847
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47067228
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43845619
30p53 signaling pathway_Homo sapiens_hsa041151.42659619
31Cell cycle_Homo sapiens_hsa041101.33204612
32N-Glycan biosynthesis_Homo sapiens_hsa005101.32583162
33Influenza A_Homo sapiens_hsa051641.21838841
34Sphingolipid metabolism_Homo sapiens_hsa006001.16211829
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16088675
36T cell receptor signaling pathway_Homo sapiens_hsa046601.15373364
37TNF signaling pathway_Homo sapiens_hsa046681.11982413
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10413381
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07801781
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07058451
41Linoleic acid metabolism_Homo sapiens_hsa005911.06826485
42Tryptophan metabolism_Homo sapiens_hsa003801.04866430
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.03143279
44Hematopoietic cell lineage_Homo sapiens_hsa046401.02381556
45RNA degradation_Homo sapiens_hsa030181.01447900
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.99203945
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96691499
48Viral carcinogenesis_Homo sapiens_hsa052030.95455269
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95272379
50Type I diabetes mellitus_Homo sapiens_hsa049400.93690646
51Antigen processing and presentation_Homo sapiens_hsa046120.88797600
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87864418
53Colorectal cancer_Homo sapiens_hsa052100.86691866
54Epstein-Barr virus infection_Homo sapiens_hsa051690.81416054
55Oocyte meiosis_Homo sapiens_hsa041140.79288597
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78754009
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77519812
58Butanoate metabolism_Homo sapiens_hsa006500.74927432
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74794088
60Histidine metabolism_Homo sapiens_hsa003400.74516738
61Herpes simplex infection_Homo sapiens_hsa051680.74300040
62Non-homologous end-joining_Homo sapiens_hsa034500.72895189
63Nitrogen metabolism_Homo sapiens_hsa009100.68569656
64Leishmaniasis_Homo sapiens_hsa051400.67065596
65Staphylococcus aureus infection_Homo sapiens_hsa051500.63890545
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.60163068
67Legionellosis_Homo sapiens_hsa051340.59805317
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58614877
69HTLV-I infection_Homo sapiens_hsa051660.56908548
70Protein export_Homo sapiens_hsa030600.56504890
71Rheumatoid arthritis_Homo sapiens_hsa053230.56137359
72Tuberculosis_Homo sapiens_hsa051520.51574221
73Adherens junction_Homo sapiens_hsa045200.50123827
74Hepatitis C_Homo sapiens_hsa051600.49770922
75Malaria_Homo sapiens_hsa051440.45533052
76Glycerolipid metabolism_Homo sapiens_hsa005610.45116773
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43392812
78African trypanosomiasis_Homo sapiens_hsa051430.42896723
79RNA transport_Homo sapiens_hsa030130.37467271
80NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37162699
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36163117
82Ovarian steroidogenesis_Homo sapiens_hsa049130.35590756
83Osteoclast differentiation_Homo sapiens_hsa043800.35533814
84B cell receptor signaling pathway_Homo sapiens_hsa046620.35148572
85Peroxisome_Homo sapiens_hsa041460.33014014
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.32332084
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32074910
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.31077756
89Cocaine addiction_Homo sapiens_hsa050300.30624850
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.30059724
91Prostate cancer_Homo sapiens_hsa052150.30039985
92DNA replication_Homo sapiens_hsa030300.29583594
93mRNA surveillance pathway_Homo sapiens_hsa030150.29348194
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28927803
95Tyrosine metabolism_Homo sapiens_hsa003500.26627492
96Apoptosis_Homo sapiens_hsa042100.26331224
97TGF-beta signaling pathway_Homo sapiens_hsa043500.26191221
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26189410
99Pancreatic cancer_Homo sapiens_hsa052120.23750021
100Chemokine signaling pathway_Homo sapiens_hsa040620.23156842

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