PAIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.13971005
2DNA double-strand break processing (GO:0000729)4.52633499
3proteasome assembly (GO:0043248)4.45686275
4DNA deamination (GO:0045006)4.42765345
5ribosomal small subunit biogenesis (GO:0042274)4.03563163
6mitochondrial respiratory chain complex I assembly (GO:0032981)3.96278264
7NADH dehydrogenase complex assembly (GO:0010257)3.96278264
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96278264
9termination of RNA polymerase III transcription (GO:0006386)3.95267122
10transcription elongation from RNA polymerase III promoter (GO:0006385)3.95267122
11sequestering of actin monomers (GO:0042989)3.88918773
12maturation of SSU-rRNA (GO:0030490)3.86819774
13viral transcription (GO:0019083)3.85947426
14protein complex biogenesis (GO:0070271)3.80718764
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76909598
16cotranslational protein targeting to membrane (GO:0006613)3.75805112
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.74957126
18positive regulation of mitochondrial fission (GO:0090141)3.74929778
19translational termination (GO:0006415)3.74638464
207-methylguanosine mRNA capping (GO:0006370)3.72449737
21RNA capping (GO:0036260)3.69457286
227-methylguanosine RNA capping (GO:0009452)3.69457286
23respiratory chain complex IV assembly (GO:0008535)3.69092963
24protein targeting to ER (GO:0045047)3.66560768
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.63938896
26protein localization to endoplasmic reticulum (GO:0070972)3.56823141
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54173830
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54173830
29ribosomal large subunit biogenesis (GO:0042273)3.52631999
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.49934320
31cullin deneddylation (GO:0010388)3.49603415
32mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49578842
33mitochondrial respiratory chain complex assembly (GO:0033108)3.48235569
34guanosine-containing compound biosynthetic process (GO:1901070)3.37465261
35establishment of integrated proviral latency (GO:0075713)3.36704167
36GTP biosynthetic process (GO:0006183)3.35997739
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.34368717
38translational elongation (GO:0006414)3.32583801
39negative regulation of ligase activity (GO:0051352)3.31936322
40negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.31936322
41protein deneddylation (GO:0000338)3.30895117
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30323153
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30022374
44telomere maintenance via semi-conservative replication (GO:0032201)3.22333487
45mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20311127
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17826970
47mannosylation (GO:0097502)3.16519742
48protein neddylation (GO:0045116)3.16272971
49regulation of cellular amino acid metabolic process (GO:0006521)3.12325364
50DNA damage response, detection of DNA damage (GO:0042769)3.12260089
51CENP-A containing nucleosome assembly (GO:0034080)3.10789892
52translation (GO:0006412)3.08366658
53rRNA modification (GO:0000154)3.07421453
54iron-sulfur cluster assembly (GO:0016226)3.07342059
55metallo-sulfur cluster assembly (GO:0031163)3.07342059
56transcription-coupled nucleotide-excision repair (GO:0006283)3.06410027
57pyrimidine nucleobase catabolic process (GO:0006208)3.06062240
58cellular protein complex disassembly (GO:0043624)3.05494199
59epithelial cilium movement (GO:0003351)3.05435800
60protein localization to cilium (GO:0061512)3.04732306
61ATP synthesis coupled proton transport (GO:0015986)3.02793625
62energy coupled proton transport, down electrochemical gradient (GO:0015985)3.02793625
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01434939
64cellular component biogenesis (GO:0044085)3.00936536
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00796826
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00796826
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00796826
68platelet dense granule organization (GO:0060155)3.00527537
69viral life cycle (GO:0019058)3.00068675
70CTP biosynthetic process (GO:0006241)2.99882327
71CTP metabolic process (GO:0046036)2.99882327
72chaperone-mediated protein transport (GO:0072321)2.99845396
73intraciliary transport (GO:0042073)2.98513672
74L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98221701
75ribonucleoprotein complex biogenesis (GO:0022613)2.96687014
76intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96393452
77signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96393452
78translational initiation (GO:0006413)2.95043558
79chromatin remodeling at centromere (GO:0031055)2.94906722
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94716802
81exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.94038378
82peptidyl-histidine modification (GO:0018202)2.93037473
83rRNA methylation (GO:0031167)2.90613657
84regulation of cilium movement (GO:0003352)2.90205491
85positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89080151
86signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88704218
87signal transduction involved in DNA damage checkpoint (GO:0072422)2.88704218
88pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.88240767
89establishment of viral latency (GO:0019043)2.88177824
90nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.88160666
91cytochrome complex assembly (GO:0017004)2.88150937
92histone H2A acetylation (GO:0043968)2.87403105
93signal transduction involved in cell cycle checkpoint (GO:0072395)2.87254994
94amino acid salvage (GO:0043102)2.86032396
95L-methionine salvage (GO:0071267)2.86032396
96L-methionine biosynthetic process (GO:0071265)2.86032396
97transcription elongation from RNA polymerase I promoter (GO:0006362)2.85957420
98positive regulation of ligase activity (GO:0051351)2.85509000
99maturation of 5.8S rRNA (GO:0000460)2.85032402
100negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.84143338
101regulation of mitochondrial translation (GO:0070129)2.83978519
102DNA catabolic process, exonucleolytic (GO:0000738)2.83268859
103DNA strand elongation involved in DNA replication (GO:0006271)2.82602165
104termination of RNA polymerase I transcription (GO:0006363)2.82015191
105telomere maintenance via recombination (GO:0000722)2.81733126
106pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.81035666
107axoneme assembly (GO:0035082)2.81004151
108DNA strand elongation (GO:0022616)2.80675344
109antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.80031534
110transcription elongation from RNA polymerase II promoter (GO:0006368)2.79433283
111UTP biosynthetic process (GO:0006228)2.78416233
112GPI anchor biosynthetic process (GO:0006506)2.77881869
113pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77071727
114spliceosomal complex assembly (GO:0000245)2.76439704
115spliceosomal snRNP assembly (GO:0000387)2.75744205
116viral mRNA export from host cell nucleus (GO:0046784)2.74610141
117fatty acid elongation (GO:0030497)2.72007368
118negative regulation of heart rate (GO:0010459)2.69926865
119organelle disassembly (GO:1903008)2.69607278
120respiratory electron transport chain (GO:0022904)2.64650293
121electron transport chain (GO:0022900)2.64450156
122DNA ligation (GO:0006266)2.64236362
123protein K11-linked ubiquitination (GO:0070979)2.63307867
124histone exchange (GO:0043486)2.61110557
125neural tube formation (GO:0001841)2.59067112
126ubiquinone metabolic process (GO:0006743)2.58722789
127DNA integration (GO:0015074)2.58196163
128protein-cofactor linkage (GO:0018065)2.56812936
129negative regulation of telomere maintenance (GO:0032205)2.56338480
130histone mRNA metabolic process (GO:0008334)2.56325650
131cilium morphogenesis (GO:0060271)2.55646229
132branched-chain amino acid catabolic process (GO:0009083)2.55530372
133regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55077303
134regulation of mitotic spindle checkpoint (GO:1903504)2.55077303
135GPI anchor metabolic process (GO:0006505)2.54909846
136purine-containing compound salvage (GO:0043101)2.54486464
137adenosine metabolic process (GO:0046085)2.53151732
138RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.51950534
139fucose catabolic process (GO:0019317)2.49920828
140L-fucose metabolic process (GO:0042354)2.49920828
141L-fucose catabolic process (GO:0042355)2.49920828
142seminiferous tubule development (GO:0072520)2.49761235
143microtubule depolymerization (GO:0007019)2.47843290
144ubiquinone biosynthetic process (GO:0006744)2.45221571
145base-excision repair, AP site formation (GO:0006285)2.43601592
146DNA demethylation (GO:0080111)2.43158342
147preassembly of GPI anchor in ER membrane (GO:0016254)2.41976751
148anterograde synaptic vesicle transport (GO:0048490)2.41657650
149pyrimidine nucleotide catabolic process (GO:0006244)2.41069826
150regulation of helicase activity (GO:0051095)2.40671688
151cilium movement (GO:0003341)2.40491092
152cilium or flagellum-dependent cell motility (GO:0001539)2.39847389
153male meiosis (GO:0007140)2.39733512
154negative regulation of thymocyte apoptotic process (GO:0070244)2.38669854
155negative regulation of response to food (GO:0032096)2.38132933
156negative regulation of appetite (GO:0032099)2.38132933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.36753118
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.35130250
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.88719782
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.67967261
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.52063944
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.45848190
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.33806479
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29552695
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.27459823
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.26238296
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.19031506
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95133258
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.88779582
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84730798
15ZNF274_21170338_ChIP-Seq_K562_Hela2.82938754
16VDR_23849224_ChIP-Seq_CD4+_Human2.79408140
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.76059365
18VDR_22108803_ChIP-Seq_LS180_Human2.70986909
19E2F7_22180533_ChIP-Seq_HELA_Human2.69799585
20* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.41459154
21FOXP3_21729870_ChIP-Seq_TREG_Human2.37567688
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.36347726
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35871692
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32468311
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30487157
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.28859467
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24492836
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23367704
29GBX2_23144817_ChIP-Seq_PC3_Human2.21221972
30* ELK1_19687146_ChIP-ChIP_HELA_Human2.17924515
31E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15078656
32DCP1A_22483619_ChIP-Seq_HELA_Human2.03863073
33* HOXB4_20404135_ChIP-ChIP_EML_Mouse2.03444188
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01181662
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00885224
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00837016
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99559778
38TTF2_22483619_ChIP-Seq_HELA_Human1.93292396
39* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93059138
40P300_19829295_ChIP-Seq_ESCs_Human1.91403625
41XRN2_22483619_ChIP-Seq_HELA_Human1.91394413
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89621800
43* GABP_19822575_ChIP-Seq_HepG2_Human1.86951171
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86035780
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84045234
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80050116
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79249682
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.79123266
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76252355
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76047989
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68358118
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66158580
53EZH2_22144423_ChIP-Seq_EOC_Human1.66111232
54IRF1_19129219_ChIP-ChIP_H3396_Human1.64556195
55* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63555563
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63359719
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63312260
58* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59126734
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55167515
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.55013698
61ER_23166858_ChIP-Seq_MCF-7_Human1.50813672
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41447409
63CIITA_25753668_ChIP-Seq_RAJI_Human1.40668763
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40008595
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37819349
66TP53_22573176_ChIP-Seq_HFKS_Human1.37187346
67MYC_18940864_ChIP-ChIP_HL60_Human1.37017401
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35769228
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33800946
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33753414
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.31838205
72* FUS_26573619_Chip-Seq_HEK293_Human1.30816980
73SOX2_19829295_ChIP-Seq_ESCs_Human1.29183105
74NANOG_19829295_ChIP-Seq_ESCs_Human1.29183105
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28752511
76TAF15_26573619_Chip-Seq_HEK293_Human1.27101949
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27092002
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27012389
79* CBP_20019798_ChIP-Seq_JUKART_Human1.26995591
80* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26995591
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24366328
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22070535
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19969109
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19720355
85HTT_18923047_ChIP-ChIP_STHdh_Human1.19586618
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19519075
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16525289
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.16144000
89* EWS_26573619_Chip-Seq_HEK293_Human1.14211315
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12321859
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11030561
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09905873
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.09905873
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09880799
95SMAD4_21799915_ChIP-Seq_A2780_Human1.07989414
96AR_20517297_ChIP-Seq_VCAP_Human1.07753405
97* ELK1_22589737_ChIP-Seq_MCF10A_Human1.06164254
98BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06018716
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.04295215
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01809645
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01495331
102POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01429839
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01096256
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00222426
105SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00128470
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99344815
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98936057
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.98708586
109AR_25329375_ChIP-Seq_VCAP_Human0.97692957
110NFE2_27457419_Chip-Seq_LIVER_Mouse0.97122817
111* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96701733
112CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95240292
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94931768
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94611788
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.93903398
116CRX_20693478_ChIP-Seq_RETINA_Mouse0.93206004
117TAL1_26923725_Chip-Seq_HPCs_Mouse0.90931700
118TCF4_22108803_ChIP-Seq_LS180_Human0.90065802
119* NCOR_22424771_ChIP-Seq_293T_Human0.89785284
120GATA3_21878914_ChIP-Seq_MCF-7_Human0.88166714
121ZFP57_27257070_Chip-Seq_ESCs_Mouse0.88044678
122RUNX2_22187159_ChIP-Seq_PCA_Human0.87595856
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86957507
124BCAT_22108803_ChIP-Seq_LS180_Human0.86933408
125IGF1R_20145208_ChIP-Seq_DFB_Human0.86295751
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85965345
127CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.85587222
128P53_22387025_ChIP-Seq_ESCs_Mouse0.85263394
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.84823747
130RNF2_27304074_Chip-Seq_NSC_Mouse0.84460089
131* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83593977
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83399766
133SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83141637
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82791940
135CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.79608276
136IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79351488
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78923693
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.78885124
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78411028
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78200449
141E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77385746
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77105875
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76690864
144E2F1_21310950_ChIP-Seq_MCF-7_Human0.76125942
145GATA1_22025678_ChIP-Seq_K562_Human0.73771711
146* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.72165503
147* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.71624468
148SCL_19346495_ChIP-Seq_HPC-7_Human0.71515348
149SOX2_16153702_ChIP-ChIP_HESCs_Human0.71309180
150SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.70920807

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.74668324
2MP0001188_hyperpigmentation3.17141572
3MP0006292_abnormal_olfactory_placode2.96505839
4MP0008058_abnormal_DNA_repair2.88992280
5MP0001986_abnormal_taste_sensitivity2.68735203
6MP0009379_abnormal_foot_pigmentation2.68693414
7MP0001529_abnormal_vocalization2.33759628
8MP0005499_abnormal_olfactory_system2.25709205
9MP0005394_taste/olfaction_phenotype2.25709205
10MP0010094_abnormal_chromosome_stability2.18324683
11MP0003693_abnormal_embryo_hatching2.12536914
12MP0003787_abnormal_imprinting2.11094609
13MP0003786_premature_aging2.07801156
14MP0001905_abnormal_dopamine_level2.05665613
15MP0004957_abnormal_blastocyst_morpholog2.03351111
16MP0008057_abnormal_DNA_replication2.01864645
17MP0004147_increased_porphyrin_level1.94315433
18MP0003121_genomic_imprinting1.89178705
19MP0003880_abnormal_central_pattern1.88934818
20MP0002653_abnormal_ependyma_morphology1.86795321
21MP0003123_paternal_imprinting1.85710647
22MP0008007_abnormal_cellular_replicative1.84069939
23MP0008995_early_reproductive_senescence1.83954272
24MP0005379_endocrine/exocrine_gland_phen1.80701424
25MP0002396_abnormal_hematopoietic_system1.72711734
26MP0006072_abnormal_retinal_apoptosis1.69723849
27MP0003077_abnormal_cell_cycle1.66847164
28MP0002163_abnormal_gland_morphology1.65772115
29MP0008260_abnormal_autophagy1.63189230
30MP0002638_abnormal_pupillary_reflex1.58833876
31MP0009046_muscle_twitch1.58204598
32MP0003111_abnormal_nucleus_morphology1.54842351
33MP0006036_abnormal_mitochondrial_physio1.53796249
34MP0003122_maternal_imprinting1.49378363
35MP0006276_abnormal_autonomic_nervous1.48983586
36MP0005409_darkened_coat_color1.48423701
37MP0002938_white_spotting1.48147905
38MP0002095_abnormal_skin_pigmentation1.47651543
39MP0005646_abnormal_pituitary_gland1.45684409
40MP0002751_abnormal_autonomic_nervous1.45230128
41MP0005551_abnormal_eye_electrophysiolog1.44365966
42MP0002822_catalepsy1.43795021
43MP0000372_irregular_coat_pigmentation1.42114434
44MP0005410_abnormal_fertilization1.41714434
45MP0008932_abnormal_embryonic_tissue1.40726847
46MP0004142_abnormal_muscle_tone1.40638505
47MP0009745_abnormal_behavioral_response1.39441073
48MP0003011_delayed_dark_adaptation1.39405989
49MP0002210_abnormal_sex_determination1.39245880
50MP0002837_dystrophic_cardiac_calcinosis1.39169606
51MP0002132_abnormal_respiratory_system1.36958020
52MP0003567_abnormal_fetal_cardiomyocyte1.36082626
53MP0003315_abnormal_perineum_morphology1.35288730
54MP0002234_abnormal_pharynx_morphology1.35119484
55MP0002102_abnormal_ear_morphology1.34918182
56MP0001486_abnormal_startle_reflex1.31444613
57MP0008872_abnormal_physiological_respon1.27083229
58MP0005464_abnormal_platelet_physiology1.26150099
59MP0000631_abnormal_neuroendocrine_gland1.24649229
60MP0003806_abnormal_nucleotide_metabolis1.23604123
61MP0005075_abnormal_melanosome_morpholog1.22799927
62* MP0001929_abnormal_gametogenesis1.20650731
63MP0002160_abnormal_reproductive_system1.17437040
64MP0003136_yellow_coat_color1.11803609
65MP0004859_abnormal_synaptic_plasticity1.10008548
66MP0003635_abnormal_synaptic_transmissio1.09199600
67MP0000681_abnormal_thyroid_gland1.08739323
68MP0002272_abnormal_nervous_system1.08286526
69MP0004133_heterotaxia1.07615893
70MP0001764_abnormal_homeostasis1.07330630
71MP0002572_abnormal_emotion/affect_behav1.06981245
72MP0000678_abnormal_parathyroid_gland1.05740377
73MP0003186_abnormal_redox_activity1.04190172
74MP0003718_maternal_effect1.01922204
75MP0010386_abnormal_urinary_bladder1.01428572
76MP0008004_abnormal_stomach_pH1.01240985
77MP0000613_abnormal_salivary_gland1.00496820
78* MP0001145_abnormal_male_reproductive1.00215349
79* MP0000653_abnormal_sex_gland0.98133588
80MP0002735_abnormal_chemical_nociception0.97013018
81MP0000049_abnormal_middle_ear0.96647376
82MP0009697_abnormal_copulation0.94976035
83MP0002064_seizures0.94950114
84MP0003763_abnormal_thymus_physiology0.94935917
85MP0004134_abnormal_chest_morphology0.92685379
86MP0006035_abnormal_mitochondrial_morpho0.91429782
87* MP0003698_abnormal_male_reproductive0.90376996
88MP0008789_abnormal_olfactory_epithelium0.90177753
89MP0001485_abnormal_pinna_reflex0.89850128
90MP0001293_anophthalmia0.89574619
91MP0002736_abnormal_nociception_after0.88942458
92MP0002009_preneoplasia0.88522725
93MP0002733_abnormal_thermal_nociception0.88489909
94MP0002557_abnormal_social/conspecific_i0.88249460
95MP0005389_reproductive_system_phenotype0.87553207
96MP0001177_atelectasis0.86819083
97MP0004145_abnormal_muscle_electrophysio0.86673412
98MP0002063_abnormal_learning/memory/cond0.86354402
99MP0005645_abnormal_hypothalamus_physiol0.85844327
100MP0001919_abnormal_reproductive_system0.85069503
101MP0002734_abnormal_mechanical_nocicepti0.84255552
102MP0003137_abnormal_impulse_conducting0.83817390
103MP0005187_abnormal_penis_morphology0.83263953
104MP0001968_abnormal_touch/_nociception0.82077030
105MP0001984_abnormal_olfaction0.81966719
106MP0000465_gastrointestinal_hemorrhage0.81473569
107MP0002277_abnormal_respiratory_mucosa0.80988007
108MP0002090_abnormal_vision0.80956180
109MP0003938_abnormal_ear_development0.79022361
110MP0002233_abnormal_nose_morphology0.77151235
111MP0004808_abnormal_hematopoietic_stem0.75996513
112MP0001270_distended_abdomen0.75865241
113MP0004084_abnormal_cardiac_muscle0.75529709
114MP0005423_abnormal_somatic_nervous0.74570370
115MP0000013_abnormal_adipose_tissue0.73546909
116MP0005167_abnormal_blood-brain_barrier0.71761962
117MP0005386_behavior/neurological_phenoty0.70660386
118MP0004924_abnormal_behavior0.70660386
119MP0003724_increased_susceptibility_to0.70062473
120MP0000566_synostosis0.69999208
121MP0003937_abnormal_limbs/digits/tail_de0.69354075
122MP0009250_abnormal_appendicular_skeleto0.67071635
123MP0004215_abnormal_myocardial_fiber0.66893943
124MP0001963_abnormal_hearing_physiology0.66385829
125MP0002184_abnormal_innervation0.66140438
126MP0000015_abnormal_ear_pigmentation0.65547486
127MP0004381_abnormal_hair_follicle0.65270465
128MP0005253_abnormal_eye_physiology0.64512159
129MP0005084_abnormal_gallbladder_morpholo0.64499666
130MP0004270_analgesia0.64186721
131MP0002067_abnormal_sensory_capabilities0.63710961
132MP0005671_abnormal_response_to0.62474620
133MP0002752_abnormal_somatic_nervous0.61415209
134MP0000026_abnormal_inner_ear0.61271680
135MP0001970_abnormal_pain_threshold0.60073260
136MP0001664_abnormal_digestion0.59854329
137MP0000490_abnormal_crypts_of0.57671700
138MP0004043_abnormal_pH_regulation0.57417786
139MP0000703_abnormal_thymus_morphology0.57136939

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.91112535
2Mitochondrial inheritance (HP:0001427)3.71104829
3Abnormal mitochondria in muscle tissue (HP:0008316)3.65198489
4Hepatocellular necrosis (HP:0001404)3.62092255
5Hypothermia (HP:0002045)3.47278468
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.46278278
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.46278278
8Aplastic anemia (HP:0001915)3.45817411
9Abnormality of cells of the erythroid lineage (HP:0012130)3.36430032
10Increased CSF lactate (HP:0002490)3.29360716
11Type 2 muscle fiber atrophy (HP:0003554)3.22016589
12Abnormal number of erythroid precursors (HP:0012131)3.12344939
13Progressive macrocephaly (HP:0004481)3.11879894
14Hepatic necrosis (HP:0002605)2.97390356
15Reticulocytopenia (HP:0001896)2.95051603
16Muscle fiber atrophy (HP:0100295)2.89561238
17Pancreatic fibrosis (HP:0100732)2.88837100
18Acute encephalopathy (HP:0006846)2.83861764
19Increased hepatocellular lipid droplets (HP:0006565)2.79425891
20Type I transferrin isoform profile (HP:0003642)2.78750960
21Retinal dysplasia (HP:0007973)2.76818638
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.76457716
23Birth length less than 3rd percentile (HP:0003561)2.72737000
24Pancreatic cysts (HP:0001737)2.69717026
25True hermaphroditism (HP:0010459)2.68643595
26Irregular epiphyses (HP:0010582)2.68490957
27Hyperalaninemia (HP:0003348)2.60285871
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60285871
29Abnormality of alanine metabolism (HP:0010916)2.60285871
30Abolished electroretinogram (ERG) (HP:0000550)2.57288007
31Lactic acidosis (HP:0003128)2.55183461
32Medial flaring of the eyebrow (HP:0010747)2.54601815
33Increased serum lactate (HP:0002151)2.54047998
34Methylmalonic acidemia (HP:0002912)2.51712773
35Absent/shortened dynein arms (HP:0200106)2.47721560
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.47721560
37Renal Fanconi syndrome (HP:0001994)2.46788358
38Microvesicular hepatic steatosis (HP:0001414)2.44521930
39Cerebral hypomyelination (HP:0006808)2.43646738
403-Methylglutaconic aciduria (HP:0003535)2.41968413
41Abnormality of the labia minora (HP:0012880)2.40108808
42Nephronophthisis (HP:0000090)2.39381084
43Exercise intolerance (HP:0003546)2.38033801
44Lipid accumulation in hepatocytes (HP:0006561)2.36892282
45Cerebral edema (HP:0002181)2.34745882
46Nephrogenic diabetes insipidus (HP:0009806)2.33386389
47Type II lissencephaly (HP:0007260)2.31185965
48Severe visual impairment (HP:0001141)2.29966152
49Congenital primary aphakia (HP:0007707)2.29731117
50Abnormal hair whorl (HP:0010721)2.28786298
51Polyphagia (HP:0002591)2.28675887
52Macrocytic anemia (HP:0001972)2.25466355
53Abnormality of the heme biosynthetic pathway (HP:0010472)2.24677901
54Gait imbalance (HP:0002141)2.23714245
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22627779
56Increased serum pyruvate (HP:0003542)2.21618980
57Abnormality of glycolysis (HP:0004366)2.21618980
58Renal cortical cysts (HP:0000803)2.20328394
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20272220
60Increased intramyocellular lipid droplets (HP:0012240)2.17622340
61Abnormal respiratory motile cilium morphology (HP:0005938)2.17030155
62Abnormal respiratory epithelium morphology (HP:0012253)2.17030155
63Atonic seizures (HP:0010819)2.16467338
64IgM deficiency (HP:0002850)2.12576322
65Hyperglycinemia (HP:0002154)2.12248634
66Pallor (HP:0000980)2.11429583
67CNS hypomyelination (HP:0003429)2.11303556
68Colon cancer (HP:0003003)2.11279762
69Abnormal protein N-linked glycosylation (HP:0012347)2.08499949
70Abnormal protein glycosylation (HP:0012346)2.08499949
71Abnormal glycosylation (HP:0012345)2.08499949
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08499949
73Severe combined immunodeficiency (HP:0004430)2.07916123
74Methylmalonic aciduria (HP:0012120)2.05776163
75Bile duct proliferation (HP:0001408)2.01706894
76Abnormal biliary tract physiology (HP:0012439)2.01706894
77Dyschromatopsia (HP:0007641)1.99652145
78Optic disc pallor (HP:0000543)1.98740165
79Abnormal ciliary motility (HP:0012262)1.98048948
80Pancytopenia (HP:0001876)1.97506731
81Respiratory difficulties (HP:0002880)1.97058473
82Congenital stationary night blindness (HP:0007642)1.96975871
83Abnormality of midbrain morphology (HP:0002418)1.96409093
84Molar tooth sign on MRI (HP:0002419)1.96409093
85Genital tract atresia (HP:0001827)1.95293154
86Male pseudohermaphroditism (HP:0000037)1.94225221
87Neuroendocrine neoplasm (HP:0100634)1.93804796
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.93452822
89Respiratory failure (HP:0002878)1.92996978
9011 pairs of ribs (HP:0000878)1.90897579
91Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.89137675
92B lymphocytopenia (HP:0010976)1.88896167
93Vaginal atresia (HP:0000148)1.88182949
94Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.87457761
95Abnormal rod and cone electroretinograms (HP:0008323)1.86268842
96Amyotrophic lateral sclerosis (HP:0007354)1.85334452
97Thyroiditis (HP:0100646)1.85059221
98Abnormality of B cell number (HP:0010975)1.84966386
99Abnormality of the renal medulla (HP:0100957)1.84788281
100Focal motor seizures (HP:0011153)1.84138458
101Progressive inability to walk (HP:0002505)1.84067578
102Dyskinesia (HP:0100660)1.84042899
103Thyroid-stimulating hormone excess (HP:0002925)1.83846798
104Nonprogressive disorder (HP:0003680)1.82695586
105Abnormality of the renal cortex (HP:0011035)1.82123936
106Exercise-induced muscle cramps (HP:0003710)1.81253335
107Carpal bone hypoplasia (HP:0001498)1.81225149
108Short tibia (HP:0005736)1.81171223
109Reduced antithrombin III activity (HP:0001976)1.80652603
110Febrile seizures (HP:0002373)1.80546176
111Leukodystrophy (HP:0002415)1.80439976
112Chronic hepatic failure (HP:0100626)1.80134242
113Exertional dyspnea (HP:0002875)1.79299161
114Decreased central vision (HP:0007663)1.78988544
115Metaphyseal dysplasia (HP:0100255)1.77681687
116Poor suck (HP:0002033)1.77024257
117Asplenia (HP:0001746)1.76189005
118Abnormality of glycine metabolism (HP:0010895)1.75942476
119Abnormality of serine family amino acid metabolism (HP:0010894)1.75942476
120Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75151659
121Hyperglycinuria (HP:0003108)1.74987471
122Aplasia/hypoplasia of the uterus (HP:0008684)1.74765369
123Hypoproteinemia (HP:0003075)1.73936203
124Generalized aminoaciduria (HP:0002909)1.73639443
125Failure to thrive in infancy (HP:0001531)1.73141392
126Optic nerve hypoplasia (HP:0000609)1.72964707
127Lethargy (HP:0001254)1.72823118
128Abnormality of the anterior horn cell (HP:0006802)1.72687439
129Degeneration of anterior horn cells (HP:0002398)1.72687439
130Lissencephaly (HP:0001339)1.72631148
131Postaxial foot polydactyly (HP:0001830)1.72525314
132Postaxial hand polydactyly (HP:0001162)1.72437192
133Abnormality of serum amino acid levels (HP:0003112)1.72371226
134Poor coordination (HP:0002370)1.72121669
135Increased muscle lipid content (HP:0009058)1.71604978
136Cerebellar dysplasia (HP:0007033)1.71248837
137Stenosis of the external auditory canal (HP:0000402)1.70433359
138Oral leukoplakia (HP:0002745)1.70427895
139Abnormal lung lobation (HP:0002101)1.69747890
140Intestinal atresia (HP:0011100)1.68900992
141Gonadotropin excess (HP:0000837)1.68116475
142Occipital encephalocele (HP:0002085)1.67324249
143Nephroblastoma (Wilms tumor) (HP:0002667)1.67045634
144Abnormal respiratory motile cilium physiology (HP:0012261)1.66343207
145Abnormality of the preputium (HP:0100587)1.65428039
146Aplasia/Hypoplasia of the tibia (HP:0005772)1.65136086
147Median cleft lip (HP:0000161)1.64771066
148Limb dystonia (HP:0002451)1.63045427

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.54796816
2MAP4K23.61960595
3BUB13.45831262
4TNIK3.23892734
5TRIM283.12060180
6WEE12.25785427
7ACVR1B2.24520496
8MKNK12.19292489
9NUAK12.17315700
10MKNK22.17220513
11CDK192.11935398
12VRK12.08828424
13MAP3K122.00539243
14ZAK2.00447709
15MUSK1.97097023
16DYRK31.85906198
17SRPK11.85767050
18MAP3K41.85184356
19BMPR1B1.81554284
20TSSK61.75195389
21EIF2AK11.72363439
22EIF2AK31.70866144
23BRSK21.68319592
24PLK41.62747542
25CSNK1G31.62017222
26CASK1.58941554
27FRK1.50400513
28NME21.44294466
29CDK81.41857201
30ADRBK21.31698958
31TEC1.31483357
32CCNB11.30312393
33PASK1.29328252
34MAPKAPK51.25792323
35MAP2K71.23900641
36RPS6KA41.20731015
37TAOK31.19763891
38TGFBR11.14998947
39MST41.13922656
40DYRK21.13124550
41CSNK1G11.12180321
42BCR1.11875231
43CSNK1A1L1.08253376
44VRK21.07943980
45NME11.06766385
46MINK11.02993706
47CDC71.02770173
48KIT1.01532201
49TLK11.00094868
50EPHA30.99573996
51FLT30.98413237
52EPHA40.96465617
53NLK0.95407239
54CSNK1G20.94278802
55MYLK0.91558378
56MAPK130.90723946
57SIK30.89709721
58INSRR0.89659523
59TXK0.89207686
60MARK10.88386833
61NEK10.86347253
62WNK30.85938067
63OXSR10.84544931
64PLK30.83032264
65PLK10.81832497
66BRAF0.81612472
67MAPK150.80585814
68NEK60.79810044
69ARAF0.78391533
70LIMK10.78254447
71PIM20.76435650
72RPS6KB20.76395417
73BRSK10.73060925
74MAP3K50.72750500
75DAPK10.72164626
76RPS6KA50.71249063
77CDK30.70997309
78CAMKK20.70479916
79YES10.68335753
80PINK10.67290184
81DAPK20.66904625
82BTK0.66274979
83AURKA0.63990193
84MARK30.63822920
85PRKCE0.63229132
86PRKCG0.61451724
87IRAK10.61064241
88TIE10.60774962
89TNK20.60093810
90STK38L0.59626830
91AURKB0.59071769
92BCKDK0.58630196
93EIF2AK20.58231142
94DYRK1A0.57016759
95PAK30.56699230
96IRAK40.55865773
97CDK140.55602852
98ATR0.55549097
99PKN10.55034719
100GRK50.54655361
101CHEK20.54371537
102CSNK2A10.53709365
103CAMK2A0.52726011
104CSNK1A10.50893063
105UHMK10.50441786
106STK390.50182163
107TESK20.50164944
108GRK10.49744378
109MAPKAPK30.45512776
110GRK70.44961800
111CSNK2A20.44440589
112CAMK2B0.42572579
113PRKCQ0.40907815
114PNCK0.40089655
115CDK70.39994389
116PRKACA0.37097228
117PRKCI0.36349813
118ITK0.35906772
119ATM0.35666576
120BMPR20.35493386
121PHKG20.35330730
122PHKG10.35330730
123MAP2K40.35263786
124CSNK1D0.34706807
125KDR0.33690944
126PBK0.33065467
127CAMK2D0.33014184
128DYRK1B0.32071360
129TTK0.31209258
130IRAK20.31077287
131PIK3CG0.30681622
132PLK20.30211765
133SYK0.29459918
134CSF1R0.28961556
135ERBB30.28959358
136OBSCN0.28878727
137CAMK2G0.28826828

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.13569867
2Proteasome_Homo sapiens_hsa030503.88041492
3RNA polymerase_Homo sapiens_hsa030203.67623744
4Protein export_Homo sapiens_hsa030603.46181017
5DNA replication_Homo sapiens_hsa030303.16798474
6Mismatch repair_Homo sapiens_hsa034303.14481661
7Oxidative phosphorylation_Homo sapiens_hsa001902.87604082
8Parkinsons disease_Homo sapiens_hsa050122.66804242
9Spliceosome_Homo sapiens_hsa030402.51295399
10Nucleotide excision repair_Homo sapiens_hsa034202.43871306
11Basal transcription factors_Homo sapiens_hsa030222.42727921
12Homologous recombination_Homo sapiens_hsa034402.40985710
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35113534
14Pyrimidine metabolism_Homo sapiens_hsa002402.34663264
15Non-homologous end-joining_Homo sapiens_hsa034502.18220779
16Base excision repair_Homo sapiens_hsa034102.13921559
17Propanoate metabolism_Homo sapiens_hsa006402.13590876
18Huntingtons disease_Homo sapiens_hsa050162.06094474
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00661966
20Purine metabolism_Homo sapiens_hsa002301.73951352
21RNA degradation_Homo sapiens_hsa030181.72155559
22Alzheimers disease_Homo sapiens_hsa050101.71242783
23RNA transport_Homo sapiens_hsa030131.66157867
24Cell cycle_Homo sapiens_hsa041101.64337989
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63225080
26Fanconi anemia pathway_Homo sapiens_hsa034601.62828245
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62009606
28Butanoate metabolism_Homo sapiens_hsa006501.61053094
29Nitrogen metabolism_Homo sapiens_hsa009101.54437296
30Olfactory transduction_Homo sapiens_hsa047401.38069142
31Steroid biosynthesis_Homo sapiens_hsa001001.37448631
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35882595
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31052405
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.22468301
35Peroxisome_Homo sapiens_hsa041461.17507679
36Regulation of autophagy_Homo sapiens_hsa041401.17258421
37beta-Alanine metabolism_Homo sapiens_hsa004101.16369946
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.16206249
39Fatty acid elongation_Homo sapiens_hsa000621.13103998
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06913729
41Primary immunodeficiency_Homo sapiens_hsa053401.06281149
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05488643
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01847899
44Type I diabetes mellitus_Homo sapiens_hsa049401.01825539
45mRNA surveillance pathway_Homo sapiens_hsa030151.00994546
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98876621
47Collecting duct acid secretion_Homo sapiens_hsa049660.94931739
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94414693
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93748637
50Folate biosynthesis_Homo sapiens_hsa007900.92045054
51Vibrio cholerae infection_Homo sapiens_hsa051100.87738953
52Alcoholism_Homo sapiens_hsa050340.83431701
53Epstein-Barr virus infection_Homo sapiens_hsa051690.83010441
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.81411344
55Vitamin B6 metabolism_Homo sapiens_hsa007500.75600459
56Graft-versus-host disease_Homo sapiens_hsa053320.74860222
57Sphingolipid metabolism_Homo sapiens_hsa006000.73332070
58One carbon pool by folate_Homo sapiens_hsa006700.72419980
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70732895
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66894618
61Arachidonic acid metabolism_Homo sapiens_hsa005900.64565431
62Phototransduction_Homo sapiens_hsa047440.63743498
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62014140
64Oocyte meiosis_Homo sapiens_hsa041140.61554633
65Nicotine addiction_Homo sapiens_hsa050330.60896276
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60146432
67Cardiac muscle contraction_Homo sapiens_hsa042600.59447648
68Metabolic pathways_Homo sapiens_hsa011000.58847279
69N-Glycan biosynthesis_Homo sapiens_hsa005100.58790393
70p53 signaling pathway_Homo sapiens_hsa041150.58701349
71Tryptophan metabolism_Homo sapiens_hsa003800.58121858
72Systemic lupus erythematosus_Homo sapiens_hsa053220.58081284
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57251999
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53993983
75Chemical carcinogenesis_Homo sapiens_hsa052040.53155460
76Serotonergic synapse_Homo sapiens_hsa047260.52750748
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51819625
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.51047255
79Fatty acid metabolism_Homo sapiens_hsa012120.50760014
80Ether lipid metabolism_Homo sapiens_hsa005650.49812602
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.49564197
82Taste transduction_Homo sapiens_hsa047420.48676654
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46409873
84Selenocompound metabolism_Homo sapiens_hsa004500.44683520
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43927595
86Carbon metabolism_Homo sapiens_hsa012000.43407811
87Circadian rhythm_Homo sapiens_hsa047100.43079862
88Synaptic vesicle cycle_Homo sapiens_hsa047210.42708803
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39900476
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.38487047
91Hematopoietic cell lineage_Homo sapiens_hsa046400.38029079
92Linoleic acid metabolism_Homo sapiens_hsa005910.37337604
93Legionellosis_Homo sapiens_hsa051340.35638303
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35177370
95Herpes simplex infection_Homo sapiens_hsa051680.35081664
96Autoimmune thyroid disease_Homo sapiens_hsa053200.34684649
97Pyruvate metabolism_Homo sapiens_hsa006200.34076500
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.33486740
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33389836
100Glutathione metabolism_Homo sapiens_hsa004800.32990864
101Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32361461
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30977144
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30497104
104Dopaminergic synapse_Homo sapiens_hsa047280.27302453
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27182246
106Rheumatoid arthritis_Homo sapiens_hsa053230.25225808
107Circadian entrainment_Homo sapiens_hsa047130.25132821
108Amphetamine addiction_Homo sapiens_hsa050310.24941148
109Morphine addiction_Homo sapiens_hsa050320.24748411
110Sulfur metabolism_Homo sapiens_hsa009200.24589636
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.23661182
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20502639
113Cocaine addiction_Homo sapiens_hsa050300.20047612
114Viral carcinogenesis_Homo sapiens_hsa052030.19677109
115Antigen processing and presentation_Homo sapiens_hsa046120.19629000
116Thyroid cancer_Homo sapiens_hsa052160.19515206
117Pentose phosphate pathway_Homo sapiens_hsa000300.16706776
118Asthma_Homo sapiens_hsa053100.16170501
119Wnt signaling pathway_Homo sapiens_hsa043100.15930342
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15077707
121GABAergic synapse_Homo sapiens_hsa047270.13956555
122Intestinal immune network for IgA production_Homo sapiens_hsa046720.12572434
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11627213
124Other glycan degradation_Homo sapiens_hsa005110.08670586
125Hedgehog signaling pathway_Homo sapiens_hsa043400.08417783
126Allograft rejection_Homo sapiens_hsa053300.08302989
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08066854
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.06566868

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