PAIP2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.72182987
2axon ensheathment in central nervous system (GO:0032291)5.19609255
3central nervous system myelination (GO:0022010)5.19609255
4piRNA metabolic process (GO:0034587)4.37941136
5cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.22543303
6presynaptic membrane assembly (GO:0097105)4.21416195
7regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.20770937
8regulation of cell communication by electrical coupling (GO:0010649)4.17992286
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.16092182
10histone H2A monoubiquitination (GO:0035518)4.13966203
11presynaptic membrane organization (GO:0097090)4.06115575
12positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.96756656
13cellular potassium ion homeostasis (GO:0030007)3.90425669
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.79954859
15regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.78138626
16regulation of relaxation of muscle (GO:1901077)3.77212176
17postsynaptic membrane organization (GO:0001941)3.73005567
18cell communication by electrical coupling (GO:0010644)3.67017691
19monoubiquitinated protein deubiquitination (GO:0035520)3.61234153
20vocalization behavior (GO:0071625)3.59376743
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.58005827
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54348951
23sodium ion export (GO:0071436)3.52951396
24actin-myosin filament sliding (GO:0033275)3.50851582
25muscle filament sliding (GO:0030049)3.50851582
26histone H2A ubiquitination (GO:0033522)3.47891127
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.47495606
28cell communication involved in cardiac conduction (GO:0086065)3.47455401
29synaptic vesicle exocytosis (GO:0016079)3.46356048
30regulation of actin filament-based movement (GO:1903115)3.43322013
31regulation of membrane repolarization (GO:0060306)3.40094832
32neuronal ion channel clustering (GO:0045161)3.38714404
33intestinal epithelial cell development (GO:0060576)3.34863344
34striated muscle contraction (GO:0006941)3.32738384
35regulation of meiosis I (GO:0060631)3.32015130
36neurotransmitter secretion (GO:0007269)3.29916579
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.29485046
38mitotic metaphase plate congression (GO:0007080)3.29316543
39potassium ion import (GO:0010107)3.28855115
40regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.28181703
41cardiac muscle contraction (GO:0060048)3.28160960
42detection of calcium ion (GO:0005513)3.27598079
43ionotropic glutamate receptor signaling pathway (GO:0035235)3.25065894
44regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25025510
45negative regulation of meiosis (GO:0045835)3.22503833
46negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21951593
47L-amino acid import (GO:0043092)3.20306071
48membrane depolarization during action potential (GO:0086010)3.20079190
49paraxial mesoderm development (GO:0048339)3.17001255
50cerebellar granule cell differentiation (GO:0021707)3.16720119
51neuron cell-cell adhesion (GO:0007158)3.12504777
52cardiac muscle hypertrophy (GO:0003300)3.11543341
53protein K6-linked ubiquitination (GO:0085020)3.07261831
54potassium ion homeostasis (GO:0055075)3.03358788
55positive regulation of synapse maturation (GO:0090129)3.03230079
56regulation of neuronal synaptic plasticity (GO:0048168)3.01532942
57neurotransmitter uptake (GO:0001504)3.01388775
58myofibril assembly (GO:0030239)3.01185138
59synaptic transmission, glutamatergic (GO:0035249)2.98298259
60regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97764974
61striated muscle hypertrophy (GO:0014897)2.94270074
62locomotory exploration behavior (GO:0035641)2.93883594
63pre-miRNA processing (GO:0031054)2.93840668
64positive regulation of potassium ion transmembrane transport (GO:1901381)2.93777892
65regulation of voltage-gated calcium channel activity (GO:1901385)2.92676970
66regulation of sister chromatid cohesion (GO:0007063)2.92360621
67otic vesicle formation (GO:0030916)2.91917136
68mitotic chromosome condensation (GO:0007076)2.91406930
69glutamate receptor signaling pathway (GO:0007215)2.89631367
70positive regulation of potassium ion transport (GO:0043268)2.89559124
71relaxation of cardiac muscle (GO:0055119)2.88708410
72mitotic sister chromatid cohesion (GO:0007064)2.88103224
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88035989
74neuromuscular synaptic transmission (GO:0007274)2.87418641
75layer formation in cerebral cortex (GO:0021819)2.85066379
76gene silencing by RNA (GO:0031047)2.85048588
77actin-mediated cell contraction (GO:0070252)2.84905674
78cardiac conduction (GO:0061337)2.84132604
79notochord development (GO:0030903)2.83169723
80DNA methylation involved in gamete generation (GO:0043046)2.83069436
81transmission of nerve impulse (GO:0019226)2.82914377
82long-chain fatty acid biosynthetic process (GO:0042759)2.82541835
83positive regulation of sodium ion transport (GO:0010765)2.82086340
84neurotransmitter-gated ion channel clustering (GO:0072578)2.80838760
85regulation of cardiac muscle cell contraction (GO:0086004)2.80717025
86positive regulation of dendritic spine development (GO:0060999)2.79718701
87positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.79526238
88regulation of sodium ion transmembrane transport (GO:1902305)2.79473270
89neuron-neuron synaptic transmission (GO:0007270)2.78588440
90DNA damage induced protein phosphorylation (GO:0006975)2.78469301
91regulation of dendritic spine development (GO:0060998)2.77998035
92relaxation of muscle (GO:0090075)2.77536025
93regulation of meiosis (GO:0040020)2.77532959
94chemosensory behavior (GO:0007635)2.77354618
95cardiac myofibril assembly (GO:0055003)2.76141974
96regulation of hippo signaling (GO:0035330)2.75523833
97neurotransmitter transport (GO:0006836)2.75044853
98regulation of sodium ion transmembrane transporter activity (GO:2000649)2.74817519
99cellular sodium ion homeostasis (GO:0006883)2.73971446
100cardiac muscle cell action potential (GO:0086001)2.73409578
101regulation of calcium ion transmembrane transporter activity (GO:1901019)2.70978280
102regulation of calcium ion transmembrane transport (GO:1903169)2.70978280
103cerebellar Purkinje cell differentiation (GO:0021702)2.70321631
104regulation of skeletal muscle contraction (GO:0014819)2.69913708
105multicellular organismal signaling (GO:0035637)2.69441753
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.69397213
107regulation of female gonad development (GO:2000194)2.68742357
108nuclear pore organization (GO:0006999)2.68471851
109dendritic spine morphogenesis (GO:0060997)2.67353062
110regulation of neurotransmitter levels (GO:0001505)2.67153547
111regulation of dendritic spine morphogenesis (GO:0061001)2.66317900
112regulation of long-term neuronal synaptic plasticity (GO:0048169)2.64305615
113protein localization to synapse (GO:0035418)2.63933712
114cardiac muscle cell action potential involved in contraction (GO:0086002)2.63378007
115gamma-aminobutyric acid transport (GO:0015812)2.60995633
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60060512
117synaptonemal complex assembly (GO:0007130)2.60048100
118regulation of glutamate receptor signaling pathway (GO:1900449)2.59131079
119male meiosis (GO:0007140)2.58198462
120synaptonemal complex organization (GO:0070193)2.58006762
121metaphase plate congression (GO:0051310)2.57632519
122regulation of synaptic vesicle exocytosis (GO:2000300)2.56794699
123histone lysine demethylation (GO:0070076)2.54301213
124Golgi transport vesicle coating (GO:0048200)2.53703532
125COPI coating of Golgi vesicle (GO:0048205)2.53703532
126attachment of spindle microtubules to kinetochore (GO:0008608)2.51955511
127peptidyl-lysine dimethylation (GO:0018027)2.48818235
128proline transport (GO:0015824)2.48569938
129histone demethylation (GO:0016577)2.46088191
130regulation of clathrin-mediated endocytosis (GO:2000369)2.46067779
131oocyte development (GO:0048599)2.45982953
132regulation of calcium ion-dependent exocytosis (GO:0017158)2.45654124
133regulation of cAMP-dependent protein kinase activity (GO:2000479)2.42364027
134sister chromatid cohesion (GO:0007062)2.41780887
135regulation of synaptic vesicle transport (GO:1902803)2.38728771
136regulation of translational termination (GO:0006449)2.38631846
137nuclear pore complex assembly (GO:0051292)2.37964340
138microtubule severing (GO:0051013)2.35430904
139protein demethylation (GO:0006482)2.34665849
140protein dealkylation (GO:0008214)2.34665849
141positive regulation of mitotic sister chromatid separation (GO:1901970)2.32686581
142positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.32686581
143positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.32686581
144oocyte maturation (GO:0001556)2.32406696
145cell migration in hindbrain (GO:0021535)2.32344300
146regulation of DNA methylation (GO:0044030)2.27702077
147vesicle transport along microtubule (GO:0047496)2.26834039
148sister chromatid segregation (GO:0000819)2.26166312
149regulation of meiotic cell cycle (GO:0051445)2.24796475
150regulation of glucocorticoid secretion (GO:2000849)2.24623900
151negative regulation of meiotic cell cycle (GO:0051447)2.24585779
152mitotic sister chromatid segregation (GO:0000070)2.22815922
153protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.22273034
154synaptic vesicle maturation (GO:0016188)2.21667319
155negative regulation of Ras GTPase activity (GO:0034261)2.20893932
156negative regulation of circadian rhythm (GO:0042754)2.20876612
157regulation of chromosome segregation (GO:0051983)2.19110863
158body morphogenesis (GO:0010171)2.18307162
159columnar/cuboidal epithelial cell development (GO:0002066)2.16824723
160anterior/posterior axis specification, embryo (GO:0008595)2.15990479
161positive regulation of chromosome segregation (GO:0051984)2.15855228
162innervation (GO:0060384)2.15824109
163synaptic vesicle docking involved in exocytosis (GO:0016081)2.15802702
164regulation of transforming growth factor beta2 production (GO:0032909)2.15489655
165neuronal action potential propagation (GO:0019227)2.15293329
166positive regulation of meiosis (GO:0045836)2.14027984
167negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.13976892
168histone ubiquitination (GO:0016574)2.12022653
169negative regulation of hormone biosynthetic process (GO:0032353)2.11309012
170negative regulation of hormone metabolic process (GO:0032351)2.11309012
171regulation of spindle organization (GO:0090224)2.10079586
172regulation of corticosteroid hormone secretion (GO:2000846)2.10023982
173gene silencing (GO:0016458)2.09821569
174regulation of RNA export from nucleus (GO:0046831)2.09721298
175negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.07809328
176positive regulation of meiotic cell cycle (GO:0051446)2.06856412
177regulation of histone H3-K27 methylation (GO:0061085)2.06331049
178plasma membrane repair (GO:0001778)2.05302928
179peptidyl-arginine modification (GO:0018195)2.05055576
180genetic imprinting (GO:0071514)2.04405666
181glutamate secretion (GO:0014047)2.04162567
182sarcoplasmic reticulum calcium ion transport (GO:0070296)2.03812213
183type B pancreatic cell development (GO:0003323)2.03707704
184negative regulation of histone methylation (GO:0031061)2.03442007
185embryonic body morphogenesis (GO:0010172)2.03420463
186female gamete generation (GO:0007292)2.02746124
187protein targeting to Golgi (GO:0000042)2.02657231
188maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.02514758
189histone monoubiquitination (GO:0010390)2.02321306
190positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.01885436
191DNA alkylation (GO:0006305)2.00329376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SALL1_21062744_ChIP-ChIP_HESCs_Human3.89782852
2GBX2_23144817_ChIP-Seq_PC3_Human3.46509727
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.73808343
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66544341
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57832995
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51480416
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.49479847
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.42817936
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20544457
10SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.14164600
11TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.14109516
12DROSHA_22980978_ChIP-Seq_HELA_Human2.11836294
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07112978
14TAF15_26573619_Chip-Seq_HEK293_Human1.97497111
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.96089004
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82639137
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81171168
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76369704
19P300_19829295_ChIP-Seq_ESCs_Human1.72600861
20PKCTHETA_26484144_Chip-Seq_BREAST_Human1.71385698
21IGF1R_20145208_ChIP-Seq_DFB_Human1.61859589
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61722909
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61339185
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60316065
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59733287
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.59077655
27RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57953806
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.55422670
29OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54577418
30RNF2_27304074_Chip-Seq_NSC_Mouse1.52364486
31EZH2_22144423_ChIP-Seq_EOC_Human1.50753168
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50626558
33SMAD3_21741376_ChIP-Seq_EPCs_Human1.50310222
34* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.49979901
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.47812263
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.45182572
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44246995
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41568863
39ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.41010202
40REST_21632747_ChIP-Seq_MESCs_Mouse1.40153856
41VDR_22108803_ChIP-Seq_LS180_Human1.40087559
42* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.38642361
43AR_21909140_ChIP-Seq_LNCAP_Human1.37184074
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36642752
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36642752
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36642752
47SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36578130
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.36250425
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36096678
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35994631
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.35366209
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34931561
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34718534
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.34130745
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.34130745
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33838801
57FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32884839
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31744580
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31414227
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31051457
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31040353
62RARB_27405468_Chip-Seq_BRAIN_Mouse1.28704230
63ZNF263_19887448_ChIP-Seq_K562_Human1.27694103
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26871540
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26593466
66ZNF274_21170338_ChIP-Seq_K562_Hela1.26068525
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25826594
68TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24604441
69POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24604441
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23848162
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23791732
72REST_18959480_ChIP-ChIP_MESCs_Mouse1.23364594
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23075930
74* NANOG_21062744_ChIP-ChIP_HESCs_Human1.22985027
75TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22958576
76FUS_26573619_Chip-Seq_HEK293_Human1.22627106
77TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21486345
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21007359
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20309840
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.19851032
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19359251
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19194585
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19192710
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19031414
85STAT3_23295773_ChIP-Seq_U87_Human1.18921746
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.18720843
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17770416
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16645689
89PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.16387201
90AR_25329375_ChIP-Seq_VCAP_Human1.15670434
91AR_21572438_ChIP-Seq_LNCaP_Human1.14867056
92TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14695955
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14520625
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14490754
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.13915892
96WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13780573
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13250985
98RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13070827
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12303855
100SMAD4_21741376_ChIP-Seq_HESCs_Human1.11945419
101* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11257885
102HTT_18923047_ChIP-ChIP_STHdh_Human1.10330137
103EZH2_27304074_Chip-Seq_ESCs_Mouse1.09973949
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09453361
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09160468
106SMAD4_21799915_ChIP-Seq_A2780_Human1.08798179
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.08068234
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07387367
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06845263
110CBP_20019798_ChIP-Seq_JUKART_Human1.06845263
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05985669
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05847745
113SOX9_26525672_Chip-Seq_HEART_Mouse1.05477237
114CBX2_27304074_Chip-Seq_ESCs_Mouse1.05306448
115EED_16625203_ChIP-ChIP_MESCs_Mouse1.05148974
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.04676069
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03952604
118E2F1_18555785_Chip-Seq_ESCs_Mouse1.03727169
119P53_22387025_ChIP-Seq_ESCs_Mouse1.03393656
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03245337
121E2F7_22180533_ChIP-Seq_HELA_Human1.02955199
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02927171
123RUNX2_22187159_ChIP-Seq_PCA_Human1.02640714
124BCAT_22108803_ChIP-Seq_LS180_Human1.02397591
125TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01896792
126SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01088533
127EWS_26573619_Chip-Seq_HEK293_Human1.00724948
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00333326
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00333164
130YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99018066
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98554723
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97716849
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97193167
134POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96785372
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96716041
136AR_19668381_ChIP-Seq_PC3_Human0.96545275
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95617482
138ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95573960
139CHD1_26751641_Chip-Seq_LNCaP_Human0.95128137
140RNF2_27304074_Chip-Seq_ESCs_Mouse0.93859359
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.93270386
142WDR5_24793694_ChIP-Seq_LNCAP_Human0.93265072
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.91691241
144TBL1_22424771_ChIP-Seq_293T_Human0.90501082
145ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89948249
146KDM2B_26808549_Chip-Seq_K562_Human0.89331149
147TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89103521
148POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88931444
149CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88756319
150E2F1_21310950_ChIP-Seq_MCF-7_Human0.88604796
151MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88199739
152* ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87785131
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87423367
154* TCF4_23295773_ChIP-Seq_U87_Human0.86026056
155* SMAD3_21741376_ChIP-Seq_ESCs_Human0.84950090
156RING1B_27294783_Chip-Seq_NPCs_Mouse0.82867542
157E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82530938
158POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82103884
159NANOG_16518401_ChIP-PET_MESCs_Mouse0.82003548
160PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81736145
161NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81252172
162REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81208899
163PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78989715
164JARID2_20064375_ChIP-Seq_MESCs_Mouse0.78594093

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.51576371
2MP0010234_abnormal_vibrissa_follicle2.74710559
3MP0001486_abnormal_startle_reflex2.61723585
4MP0002064_seizures2.58762403
5MP0003123_paternal_imprinting2.57733897
6MP0002272_abnormal_nervous_system2.53807917
7MP0008877_abnormal_DNA_methylation2.46037975
8MP0004145_abnormal_muscle_electrophysio2.42400098
9MP0009046_muscle_twitch2.35688710
10MP0003787_abnormal_imprinting2.32679199
11MP0000749_muscle_degeneration2.14788414
12MP0005187_abnormal_penis_morphology2.13172523
13MP0003890_abnormal_embryonic-extraembry2.10237028
14MP0003646_muscle_fatigue2.09576821
15MP0002877_abnormal_melanocyte_morpholog2.01830007
16MP0004215_abnormal_myocardial_fiber1.99755737
17MP0004859_abnormal_synaptic_plasticity1.95309801
18MP0004270_analgesia1.84659399
19MP0003693_abnormal_embryo_hatching1.79409158
20MP0002572_abnormal_emotion/affect_behav1.78251287
21MP0000537_abnormal_urethra_morphology1.77970509
22MP0004036_abnormal_muscle_relaxation1.77926099
23MP0006072_abnormal_retinal_apoptosis1.77515107
24MP0003121_genomic_imprinting1.76949881
25MP0008569_lethality_at_weaning1.76024192
26MP0003690_abnormal_glial_cell1.66022092
27MP0003315_abnormal_perineum_morphology1.65236145
28MP0001968_abnormal_touch/_nociception1.59796935
29MP0004084_abnormal_cardiac_muscle1.59248507
30MP0001485_abnormal_pinna_reflex1.52054409
31MP0003718_maternal_effect1.49026618
32MP0002067_abnormal_sensory_capabilities1.46597683
33MP0002909_abnormal_adrenal_gland1.46512814
34MP0004130_abnormal_muscle_cell1.45246884
35MP0002735_abnormal_chemical_nociception1.43777306
36MP0004957_abnormal_blastocyst_morpholog1.43409328
37MP0002734_abnormal_mechanical_nocicepti1.42705245
38MP0003937_abnormal_limbs/digits/tail_de1.42304572
39MP0001529_abnormal_vocalization1.41070153
40MP0003119_abnormal_digestive_system1.41015838
41MP0009780_abnormal_chondrocyte_physiolo1.39962252
42MP0003635_abnormal_synaptic_transmissio1.37274709
43MP0003879_abnormal_hair_cell1.36877151
44MP0000920_abnormal_myelination1.36361001
45MP0001501_abnormal_sleep_pattern1.35240928
46MP0005646_abnormal_pituitary_gland1.34931970
47MP0003137_abnormal_impulse_conducting1.34109810
48MP0002106_abnormal_muscle_physiology1.33207222
49MP0008789_abnormal_olfactory_epithelium1.32923851
50MP0001970_abnormal_pain_threshold1.32400007
51MP0004185_abnormal_adipocyte_glucose1.32078667
52MP0006276_abnormal_autonomic_nervous1.31128290
53MP0002084_abnormal_developmental_patter1.30472576
54MP0001346_abnormal_lacrimal_gland1.30024962
55MP0000747_muscle_weakness1.28014794
56MP0005394_taste/olfaction_phenotype1.27788386
57MP0005499_abnormal_olfactory_system1.27788386
58MP0002184_abnormal_innervation1.27444349
59MP0003633_abnormal_nervous_system1.27402507
60MP0005620_abnormal_muscle_contractility1.27202575
61MP0004233_abnormal_muscle_weight1.26909475
62MP0001929_abnormal_gametogenesis1.25371023
63MP0004087_abnormal_muscle_fiber1.24774285
64MP0005551_abnormal_eye_electrophysiolog1.24237428
65MP0006292_abnormal_olfactory_placode1.23576791
66MP0002066_abnormal_motor_capabilities/c1.23422767
67MP0003705_abnormal_hypodermis_morpholog1.22872777
68MP0010386_abnormal_urinary_bladder1.22653867
69MP0003283_abnormal_digestive_organ1.20854698
70MP0002210_abnormal_sex_determination1.20196381
71MP0002653_abnormal_ependyma_morphology1.19542233
72MP0010094_abnormal_chromosome_stability1.18301527
73MP0005369_muscle_phenotype1.17785678
74MP0003111_abnormal_nucleus_morphology1.17275570
75MP0002557_abnormal_social/conspecific_i1.16672362
76MP0001177_atelectasis1.15816888
77MP0000778_abnormal_nervous_system1.14913680
78MP0000653_abnormal_sex_gland1.14785531
79MP0002229_neurodegeneration1.14733102
80MP0000579_abnormal_nail_morphology1.14063429
81MP0002085_abnormal_embryonic_tissue1.12680085
82MP0001730_embryonic_growth_arrest1.11505833
83MP0000631_abnormal_neuroendocrine_gland1.10923203
84MP0000955_abnormal_spinal_cord1.10307913
85MP0001502_abnormal_circadian_rhythm1.10169949
86MP0004085_abnormal_heartbeat1.09139930
87MP0001440_abnormal_grooming_behavior1.08514019
88MP0002063_abnormal_learning/memory/cond1.06516343
89MP0003077_abnormal_cell_cycle1.05720955
90MP0003755_abnormal_palate_morphology1.05440608
91MP0003861_abnormal_nervous_system1.05144239
92MP0005451_abnormal_body_composition1.04986347
93MP0002972_abnormal_cardiac_muscle1.04502321
94MP0002736_abnormal_nociception_after1.04428068
95MP0005220_abnormal_exocrine_pancreas1.04411479
96MP0003122_maternal_imprinting1.03675719
97MP0004885_abnormal_endolymph1.03618867
98MP0004147_increased_porphyrin_level1.02186807
99MP0001299_abnormal_eye_distance/1.01686080
100MP0000613_abnormal_salivary_gland1.01351341
101MP0001145_abnormal_male_reproductive0.99734394
102MP0004484_altered_response_of0.99531898
103MP0003631_nervous_system_phenotype0.99191147
104MP0001849_ear_inflammation0.98999191
105MP0002269_muscular_atrophy0.98179221
106MP0005248_abnormal_Harderian_gland0.97041249
107MP0005076_abnormal_cell_differentiation0.96564910
108MP0005380_embryogenesis_phenotype0.95584835
109MP0001672_abnormal_embryogenesis/_devel0.95584835
110MP0001944_abnormal_pancreas_morphology0.95436095
111MP0002009_preneoplasia0.94967175
112MP0005645_abnormal_hypothalamus_physiol0.94123933
113MP0002332_abnormal_exercise_endurance0.94052046
114MP0002822_catalepsy0.93169405
115MP0001963_abnormal_hearing_physiology0.92066981
116MP0000759_abnormal_skeletal_muscle0.91859339
117MP0004043_abnormal_pH_regulation0.91688697
118MP0002638_abnormal_pupillary_reflex0.91504779
119MP0001188_hyperpigmentation0.90744380
120MP0005423_abnormal_somatic_nervous0.90478292
121MP0004142_abnormal_muscle_tone0.90423405
122MP0009703_decreased_birth_body0.90149045
123MP0003699_abnormal_female_reproductive0.90070700
124MP0003698_abnormal_male_reproductive0.89833112
125MP0003942_abnormal_urinary_system0.89609307
126MP0002733_abnormal_thermal_nociception0.88511943
127MP0001697_abnormal_embryo_size0.88380655
128MP0000428_abnormal_craniofacial_morphol0.88357215
129MP0005330_cardiomyopathy0.88340084
130MP0004811_abnormal_neuron_physiology0.87861575
131MP0003935_abnormal_craniofacial_develop0.87796013
132MP0001919_abnormal_reproductive_system0.87737915
133MP0002233_abnormal_nose_morphology0.87434685
134MP0002152_abnormal_brain_morphology0.87118294
135MP0005389_reproductive_system_phenotype0.86490818
136MP0004742_abnormal_vestibular_system0.86350284
137MP0000350_abnormal_cell_proliferation0.86072871
138MP0002837_dystrophic_cardiac_calcinosis0.85308864
139MP0002693_abnormal_pancreas_physiology0.84997713
140MP0001984_abnormal_olfaction0.84497745
141MP0006036_abnormal_mitochondrial_physio0.84205517
142MP0005670_abnormal_white_adipose0.84151876
143MP0010030_abnormal_orbit_morphology0.83958009
144MP0004510_myositis0.83806203
145MP0005623_abnormal_meninges_morphology0.83654698
146MP0009672_abnormal_birth_weight0.83235332
147MP0005386_behavior/neurological_phenoty0.83074183
148MP0004924_abnormal_behavior0.83074183
149MP0000566_synostosis0.83064589
150MP0005253_abnormal_eye_physiology0.82044047
151MP0002160_abnormal_reproductive_system0.81995748
152MP0002882_abnormal_neuron_morphology0.81889749
153MP0005257_abnormal_intraocular_pressure0.81068152
154MP0000751_myopathy0.80794382
155MP0009745_abnormal_behavioral_response0.79569766
156MP0002752_abnormal_somatic_nervous0.79262760
157MP0003195_calcinosis0.79096643
158MP0002234_abnormal_pharynx_morphology0.78307623
159MP0004133_heterotaxia0.76428048
160MP0008775_abnormal_heart_ventricle0.76293985
161MP0003632_abnormal_nervous_system0.76161596

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)3.66806511
2Focal seizures (HP:0007359)3.63414056
3Sudden death (HP:0001699)3.42889258
4Papillary thyroid carcinoma (HP:0002895)3.31435622
5EMG: myopathic abnormalities (HP:0003458)3.14115400
6Male infertility (HP:0003251)3.11002325
7Shoulder girdle muscle weakness (HP:0003547)3.06006221
8Type 1 muscle fiber predominance (HP:0003803)3.04561901
9Muscle fiber splitting (HP:0003555)3.02213822
10Abnormality of the calf musculature (HP:0001430)2.99051137
11Heart block (HP:0012722)2.89964831
12Action tremor (HP:0002345)2.85928522
13Subaortic stenosis (HP:0001682)2.84949723
14Abnormality of the left ventricular outflow tract (HP:0011103)2.84949723
15Epileptic encephalopathy (HP:0200134)2.83869770
16Broad-based gait (HP:0002136)2.72391628
17Ependymoma (HP:0002888)2.68761800
18Insidious onset (HP:0003587)2.66581296
19Termporal pattern (HP:0011008)2.66581296
20Progressive cerebellar ataxia (HP:0002073)2.59371488
21Increased circulating renin level (HP:0000848)2.58596789
22Ankle clonus (HP:0011448)2.57999831
23Shawl scrotum (HP:0000049)2.57891477
24Dialeptic seizures (HP:0011146)2.56861143
25Pelvic girdle muscle weakness (HP:0003749)2.54347087
26Abnormality of the labia minora (HP:0012880)2.51527421
27Abnormality of the musculature of the pelvis (HP:0001469)2.47264289
28Abnormality of the hip-girdle musculature (HP:0001445)2.47264289
29Abnormal atrioventricular conduction (HP:0005150)2.46144844
30Syncope (HP:0001279)2.45282920
31Abnormality of the astrocytes (HP:0100707)2.38284153
32Astrocytoma (HP:0009592)2.38284153
33Gaze-evoked nystagmus (HP:0000640)2.37000851
34Bundle branch block (HP:0011710)2.36434150
35Degeneration of the lateral corticospinal tracts (HP:0002314)2.34148039
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.34148039
37Spastic gait (HP:0002064)2.29661098
38Muscle fiber inclusion bodies (HP:0100299)2.26200401
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24926306
40Myoglobinuria (HP:0002913)2.23712166
41Epileptiform EEG discharges (HP:0011182)2.19801755
42Thyroid carcinoma (HP:0002890)2.19798962
43Poor eye contact (HP:0000817)2.18137197
44Atrial fibrillation (HP:0005110)2.16907483
45Myokymia (HP:0002411)2.15665974
46Hemiparesis (HP:0001269)2.15469343
47Abnormal eating behavior (HP:0100738)2.15320588
48Insulin-resistant diabetes mellitus (HP:0000831)2.10922186
49Dysdiadochokinesis (HP:0002075)2.10538937
50Abnormality of the lower motor neuron (HP:0002366)2.09352102
51Facial hemangioma (HP:0000329)2.06956822
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.05831936
53Ventricular fibrillation (HP:0001663)2.03212234
54Hyperglycemia (HP:0003074)2.03101581
55Ventricular arrhythmia (HP:0004308)2.02974233
56Frequent falls (HP:0002359)2.02069897
57Neck muscle weakness (HP:0000467)2.00897119
58Biliary tract neoplasm (HP:0100574)2.00401377
59Sleep apnea (HP:0010535)1.99917552
60Exercise-induced myalgia (HP:0003738)1.99161005
61Cortical dysplasia (HP:0002539)1.98760279
62Primary atrial arrhythmia (HP:0001692)1.97397292
63Areflexia of lower limbs (HP:0002522)1.96162080
64Abnormal social behavior (HP:0012433)1.95997767
65Impaired social interactions (HP:0000735)1.95997767
66Myopathic facies (HP:0002058)1.95398488
67Dysmetria (HP:0001310)1.95328341
68Ventricular tachycardia (HP:0004756)1.94912498
69Visual hallucinations (HP:0002367)1.94547234
70Nemaline bodies (HP:0003798)1.94294420
71Lower limb muscle weakness (HP:0007340)1.93628362
72Volvulus (HP:0002580)1.93257275
73Hypsarrhythmia (HP:0002521)1.92053771
74Rimmed vacuoles (HP:0003805)1.91291464
75Limb dystonia (HP:0002451)1.91287798
76Intention tremor (HP:0002080)1.91256603
77Hyperkalemia (HP:0002153)1.89269200
78Curly hair (HP:0002212)1.86942642
79Heterotopia (HP:0002282)1.85484744
80Polyphagia (HP:0002591)1.85407974
81Postural instability (HP:0002172)1.85358527
82Abnormality of binocular vision (HP:0011514)1.85139492
83Diplopia (HP:0000651)1.85139492
84Atonic seizures (HP:0010819)1.84659084
85Supraventricular tachycardia (HP:0004755)1.83266210
86Anxiety (HP:0000739)1.82945768
87Urinary urgency (HP:0000012)1.82919189
88Truncal ataxia (HP:0002078)1.82149145
89Centrally nucleated skeletal muscle fibers (HP:0003687)1.81576199
90Rhabdomyolysis (HP:0003201)1.80923278
91Focal motor seizures (HP:0011153)1.80238863
92Cerebral hypomyelination (HP:0006808)1.80122685
93Hypomagnesemia (HP:0002917)1.78752894
94Hypoplastic labia majora (HP:0000059)1.78505280
95Exercise-induced muscle cramps (HP:0003710)1.76720856
96Left ventricular hypertrophy (HP:0001712)1.76535728
97Atrioventricular block (HP:0001678)1.76329326
98Renal duplication (HP:0000075)1.76041329
99Drooling (HP:0002307)1.75245694
100Excessive salivation (HP:0003781)1.75245694
101Fibular aplasia (HP:0002990)1.74581495
102Hyperventilation (HP:0002883)1.74565968
103Prolonged QT interval (HP:0001657)1.74522366
104Glioma (HP:0009733)1.74294011
105Supraventricular arrhythmia (HP:0005115)1.74218391
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73941930
107Abnormality of the corticospinal tract (HP:0002492)1.72437557
108Sandal gap (HP:0001852)1.72363885
109Urinary bladder sphincter dysfunction (HP:0002839)1.72240710
110Pheochromocytoma (HP:0002666)1.71689108
111Abnormal pancreas size (HP:0012094)1.70575574
112Scanning speech (HP:0002168)1.70241514
113Deformed tarsal bones (HP:0008119)1.69994189
114Fetal akinesia sequence (HP:0001989)1.69640591
115Calcaneovalgus deformity (HP:0001848)1.69551650
116Enlarged penis (HP:0000040)1.69518490
117Status epilepticus (HP:0002133)1.69164194
118Abnormality of the labia majora (HP:0012881)1.68597290
119Difficulty running (HP:0009046)1.67967756
120Hyperglycinemia (HP:0002154)1.66641967
121Intestinal polyposis (HP:0200008)1.65953105
122Hepatoblastoma (HP:0002884)1.64907845
123Absent eyebrow (HP:0002223)1.64667509
124Gait imbalance (HP:0002141)1.64528602
125Cystic hygroma (HP:0000476)1.63761565
126Neoplasm of the thyroid gland (HP:0100031)1.63154443
127Distal arthrogryposis (HP:0005684)1.62323827
128Infertility (HP:0000789)1.59672188
129Intestinal polyp (HP:0005266)1.59267110
130Megalencephaly (HP:0001355)1.58481596
131Hyperinsulinemic hypoglycemia (HP:0000825)1.58476108
132Anosmia (HP:0000458)1.56885398
133Absence seizures (HP:0002121)1.56868483
134Breast aplasia (HP:0100783)1.56621891
135Aplasia/Hypoplasia of the sternum (HP:0006714)1.56583860
136Rectal prolapse (HP:0002035)1.56102984
137Hypogonadotrophic hypogonadism (HP:0000044)1.56028406
138Amyotrophic lateral sclerosis (HP:0007354)1.55862735
139Impaired vibration sensation in the lower limbs (HP:0002166)1.55856873
140Microglossia (HP:0000171)1.54593215
141Subacute progressive viral hepatitis (HP:0006572)1.53312782
142Hyporeflexia of lower limbs (HP:0002600)1.51935309
143Primary amenorrhea (HP:0000786)1.50616502
144Adenoma sebaceum (HP:0009720)1.50562757
145Angiofibromas (HP:0010615)1.50562757
146Abnormal biliary tract morphology (HP:0012440)1.49712972
147Impulsivity (HP:0100710)1.49441377
148Posterior subcapsular cataract (HP:0007787)1.49389423
149Muscle hypertrophy of the lower extremities (HP:0008968)1.48217736
150Proximal amyotrophy (HP:0007126)1.47742555
151Abnormality of the fovea (HP:0000493)1.47007446
152Abnormality of the shoulder girdle musculature (HP:0001435)1.46830560
153Papilledema (HP:0001085)1.46755877
154EEG with generalized epileptiform discharges (HP:0011198)1.45843708
155Short 1st metacarpal (HP:0010034)1.45575102
156Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.45575102
157Deep palmar crease (HP:0006191)1.45079295
158Generalized tonic-clonic seizures (HP:0002069)1.44989599
159Resting tremor (HP:0002322)1.44989512
160Colon cancer (HP:0003003)1.44585486
161Rhabdomyosarcoma (HP:0002859)1.44373074
162EMG: neuropathic changes (HP:0003445)1.43796336
163Febrile seizures (HP:0002373)1.43497648
164Breast hypoplasia (HP:0003187)1.43201547
165Germ cell neoplasia (HP:0100728)1.42914053
166Cutaneous finger syndactyly (HP:0010554)1.42296421
167Morphological abnormality of the pyramidal tract (HP:0002062)1.41837447
168Hyperthyroidism (HP:0000836)1.41397991
169Myotonia (HP:0002486)1.41096790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.79296902
2LATS23.82317051
3MAP3K92.98061829
4STK38L2.54871347
5MAP3K42.51401545
6PRKD32.48153752
7DAPK22.33538689
8AKT32.32857960
9CASK2.17043553
10MARK12.17004941
11TNIK1.98992565
12KSR21.98692202
13MAP3K61.92222418
14NEK11.72851235
15FRK1.67216390
16STK381.60172366
17STK31.59101285
18EEF2K1.58959122
19PAK61.58428111
20MAP2K71.57518977
21WNK31.53361305
22TTK1.53184916
23MAP3K21.52683623
24MAP2K41.51760738
25ERBB41.50692175
26NTRK31.47713699
27CAMK11.44655425
28PHKG11.41531599
29PHKG21.41531599
30CDC71.40461480
31PASK1.39001792
32NEK21.28832471
33CDK191.28823542
34CAMK2B1.27641578
35TYRO31.27274383
36OXSR11.24923329
37MAPK131.24032831
38PLK41.23547177
39PDK41.22142717
40PDK31.22142717
41MAP4K21.18622115
42TAOK11.18238820
43TTN1.14740170
44CAMK2A1.13423911
45STK391.11589169
46RET1.11078111
47PRKCG1.10090619
48CDK121.06658157
49CAMK2D1.04243793
50TRIM281.03856054
51PLK31.02593690
52CHEK21.02190134
53PKN11.01326355
54DYRK21.00732067
55KSR11.00378517
56ALK0.97151810
57CAMK2G0.95395641
58OBSCN0.93675128
59PDGFRA0.93067687
60MELK0.93026038
61BRAF0.89421635
62BRSK20.87583067
63CAMK40.87552773
64BRSK10.87349874
65MINK10.87331113
66TAOK30.87249609
67PINK10.85922759
68NTRK10.85918313
69FER0.85351899
70EPHA40.83971922
71PDK20.83288533
72MAPK120.82270212
73SGK10.80347132
74STK240.78686171
75TRIB30.78646650
76PRKAA10.78493870
77NTRK20.78332329
78SGK30.78047042
79MAP3K70.77614274
80PLK20.76065911
81GRK50.75777742
82PLK10.75313364
83CDK80.74026839
84INSRR0.73689769
85WNK10.72497080
86BMPR1B0.70324829
87PRKG10.68960415
88HIPK20.67182251
89CSNK1G20.66058236
90STK110.64432424
91DAPK10.63841892
92PRKCE0.63812400
93CHEK10.63779490
94MAPKAPK30.63716424
95RPS6KB20.60709352
96MKNK20.60606074
97PRKCI0.60107812
98NLK0.59937740
99CAMK1G0.58929309
100SRPK10.57569409
101PKN20.56693982
102PDGFRB0.55857844
103PAK30.55395122
104TSSK60.54908101
105CAMKK20.53269479
106ERBB30.53229508
107CAMKK10.51876198
108AURKA0.51719088
109ICK0.51511212
110CSNK1E0.51084206
111MAPK100.50694959
112ATM0.50632125
113CDK20.50599990
114DMPK0.50204536
115GRK10.49788741
116PRKCH0.49463068
117PRKACA0.49434670
118CSNK1D0.48602178
119RPS6KB10.48156690
120RAF10.48122601
121CDK10.47605855
122PRKAA20.46386795
123NEK60.45031860
124CSNK1G10.44801746
125ACVR1B0.44343627
126CDK50.44220267
127DYRK1A0.44116736
128RIPK10.44060879
129ARAF0.42820416
130MTOR0.42477692
131MAPKAPK50.41421717
132PNCK0.40063636
133AURKB0.39865046
134ROCK10.39381554
135ROCK20.39326515
136SGK20.38936258
137MARK20.38257011
138CSNK1A10.38177435
139FGFR20.38000756
140PRKD10.37265390
141PRKDC0.37004906
142RPS6KA30.36560503
143MAP2K60.36343293
144GSK3B0.36186348
145UHMK10.35814760
146PRKACB0.35149659
147PRKCZ0.34906979
148PIK3CA0.34109772
149MAPK140.33190542
150SGK4940.31712802
151SGK2230.31712802

Predicted pathways (KEGG)

RankGene SetZ-score
1Oocyte meiosis_Homo sapiens_hsa041142.21780554
2mTOR signaling pathway_Homo sapiens_hsa041502.09970166
3Cardiac muscle contraction_Homo sapiens_hsa042602.07500007
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.02413443
5Long-term potentiation_Homo sapiens_hsa047201.95696730
6Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.91134389
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87920650
8Circadian rhythm_Homo sapiens_hsa047101.80824548
9Insulin secretion_Homo sapiens_hsa049111.76109670
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.76081217
11Synaptic vesicle cycle_Homo sapiens_hsa047211.72247251
12RNA transport_Homo sapiens_hsa030131.64754362
13Propanoate metabolism_Homo sapiens_hsa006401.64384229
14mRNA surveillance pathway_Homo sapiens_hsa030151.62987906
15Endometrial cancer_Homo sapiens_hsa052131.60392761
16Arginine and proline metabolism_Homo sapiens_hsa003301.58212595
17Dopaminergic synapse_Homo sapiens_hsa047281.56725676
18Amphetamine addiction_Homo sapiens_hsa050311.55356941
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51012177
20Dorso-ventral axis formation_Homo sapiens_hsa043201.50862767
21Histidine metabolism_Homo sapiens_hsa003401.50802453
22Hippo signaling pathway_Homo sapiens_hsa043901.50056007
23beta-Alanine metabolism_Homo sapiens_hsa004101.47922915
24GnRH signaling pathway_Homo sapiens_hsa049121.44566937
25Type II diabetes mellitus_Homo sapiens_hsa049301.38653044
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37036002
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36484801
28Pancreatic secretion_Homo sapiens_hsa049721.35167206
29Cell cycle_Homo sapiens_hsa041101.32912426
30Vitamin B6 metabolism_Homo sapiens_hsa007501.32742196
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32718702
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.31830810
33Olfactory transduction_Homo sapiens_hsa047401.30803341
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30797094
35Cholinergic synapse_Homo sapiens_hsa047251.30050077
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.28799492
37Nicotine addiction_Homo sapiens_hsa050331.28249499
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27532399
39Estrogen signaling pathway_Homo sapiens_hsa049151.25725768
40Basal transcription factors_Homo sapiens_hsa030221.25277409
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.23959676
42Tight junction_Homo sapiens_hsa045301.23211177
43RNA degradation_Homo sapiens_hsa030181.22264910
44Insulin signaling pathway_Homo sapiens_hsa049101.19962842
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.19720544
46Glioma_Homo sapiens_hsa052141.17778168
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17743422
48Butanoate metabolism_Homo sapiens_hsa006501.17212682
49Long-term depression_Homo sapiens_hsa047301.16839035
50GABAergic synapse_Homo sapiens_hsa047271.16546746
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16064650
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15727154
53Prolactin signaling pathway_Homo sapiens_hsa049171.15257475
54Oxytocin signaling pathway_Homo sapiens_hsa049211.13752502
55Glucagon signaling pathway_Homo sapiens_hsa049221.12653152
56Colorectal cancer_Homo sapiens_hsa052101.11559341
57Circadian entrainment_Homo sapiens_hsa047131.11201849
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10541980
59Renal cell carcinoma_Homo sapiens_hsa052111.09148605
60Thyroid cancer_Homo sapiens_hsa052161.08818207
61Inositol phosphate metabolism_Homo sapiens_hsa005621.07938075
62Glutamatergic synapse_Homo sapiens_hsa047241.07188840
63ErbB signaling pathway_Homo sapiens_hsa040121.06766222
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05549696
65Arginine biosynthesis_Homo sapiens_hsa002201.04634675
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03222470
67Taste transduction_Homo sapiens_hsa047421.02820538
68Wnt signaling pathway_Homo sapiens_hsa043101.02624201
69Phototransduction_Homo sapiens_hsa047441.01426140
70Bile secretion_Homo sapiens_hsa049761.00876072
71Melanogenesis_Homo sapiens_hsa049160.99683434
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99337788
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98450508
74Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97960256
75Ovarian steroidogenesis_Homo sapiens_hsa049130.97803488
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97610102
77Renin secretion_Homo sapiens_hsa049240.95346955
78Cocaine addiction_Homo sapiens_hsa050300.94968851
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94693211
80Adherens junction_Homo sapiens_hsa045200.93458704
81Salivary secretion_Homo sapiens_hsa049700.93060622
82Hedgehog signaling pathway_Homo sapiens_hsa043400.92796158
83FoxO signaling pathway_Homo sapiens_hsa040680.92031244
84Non-small cell lung cancer_Homo sapiens_hsa052230.91563429
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91171479
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90942230
87VEGF signaling pathway_Homo sapiens_hsa043700.90043091
88Gap junction_Homo sapiens_hsa045400.89377808
89Gastric acid secretion_Homo sapiens_hsa049710.87951746
90TGF-beta signaling pathway_Homo sapiens_hsa043500.86790620
91AMPK signaling pathway_Homo sapiens_hsa041520.86386539
92Morphine addiction_Homo sapiens_hsa050320.82712101
93Pyruvate metabolism_Homo sapiens_hsa006200.81418008
94Fatty acid degradation_Homo sapiens_hsa000710.80594080
95Protein export_Homo sapiens_hsa030600.80400431
96Regulation of autophagy_Homo sapiens_hsa041400.78415961
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77436480
98Serotonergic synapse_Homo sapiens_hsa047260.76809257
99Choline metabolism in cancer_Homo sapiens_hsa052310.76776811
100Prostate cancer_Homo sapiens_hsa052150.76655893
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75599487
102RNA polymerase_Homo sapiens_hsa030200.74934336
103Nitrogen metabolism_Homo sapiens_hsa009100.73605351
104MicroRNAs in cancer_Homo sapiens_hsa052060.73521852
105Melanoma_Homo sapiens_hsa052180.70623007
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.70477586
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69500095
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.69408026
109Tryptophan metabolism_Homo sapiens_hsa003800.69111970
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.68483024
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.67883632
112Basal cell carcinoma_Homo sapiens_hsa052170.67731602
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66616524
114Axon guidance_Homo sapiens_hsa043600.66415460
115Calcium signaling pathway_Homo sapiens_hsa040200.66410068
116MAPK signaling pathway_Homo sapiens_hsa040100.66063159
117Dilated cardiomyopathy_Homo sapiens_hsa054140.65586679
118Insulin resistance_Homo sapiens_hsa049310.65159414
119cAMP signaling pathway_Homo sapiens_hsa040240.63845464
120Alcoholism_Homo sapiens_hsa050340.63422189
121Pancreatic cancer_Homo sapiens_hsa052120.63191095
122Vibrio cholerae infection_Homo sapiens_hsa051100.61925807
123Fatty acid metabolism_Homo sapiens_hsa012120.60578144
124Mineral absorption_Homo sapiens_hsa049780.60442441
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60023861
126Alzheimers disease_Homo sapiens_hsa050100.59585345
127Ether lipid metabolism_Homo sapiens_hsa005650.58815892
128Linoleic acid metabolism_Homo sapiens_hsa005910.58793660
129Collecting duct acid secretion_Homo sapiens_hsa049660.58258737
130Thyroid hormone synthesis_Homo sapiens_hsa049180.57086293
131Carbon metabolism_Homo sapiens_hsa012000.56890669
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56545878
133Ras signaling pathway_Homo sapiens_hsa040140.56119344
134Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52878080
135Parkinsons disease_Homo sapiens_hsa050120.52808944
136Oxidative phosphorylation_Homo sapiens_hsa001900.48263578
137Phenylalanine metabolism_Homo sapiens_hsa003600.47437081
138Fatty acid elongation_Homo sapiens_hsa000620.46728872
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45134918
140Peroxisome_Homo sapiens_hsa041460.44093657
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37261725

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