PAK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.85083437
2glutamate secretion (GO:0014047)5.72589531
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.69659158
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66958438
5synaptic vesicle maturation (GO:0016188)5.50632117
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45296088
7regulation of synaptic vesicle exocytosis (GO:2000300)5.45033423
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.33287889
9neuronal action potential propagation (GO:0019227)5.23302617
10vocalization behavior (GO:0071625)5.17309000
11locomotory exploration behavior (GO:0035641)5.02491689
12neuron cell-cell adhesion (GO:0007158)5.02176861
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83029016
14protein localization to synapse (GO:0035418)4.80397204
15presynaptic membrane assembly (GO:0097105)4.75520917
16regulation of synaptic vesicle transport (GO:1902803)4.71452942
17regulation of glutamate receptor signaling pathway (GO:1900449)4.70057217
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.61446877
19presynaptic membrane organization (GO:0097090)4.59699573
20cerebellar granule cell differentiation (GO:0021707)4.41602107
21synaptic transmission, glutamatergic (GO:0035249)4.38745478
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.33259403
23neurotransmitter secretion (GO:0007269)4.31792888
24negative regulation of cell killing (GO:0031342)4.28472979
25negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.28472979
26neurotransmitter-gated ion channel clustering (GO:0072578)4.26342245
27neuron-neuron synaptic transmission (GO:0007270)4.26022054
28glutamate receptor signaling pathway (GO:0007215)4.22420226
29regulation of ARF protein signal transduction (GO:0032012)4.14277913
30gamma-aminobutyric acid signaling pathway (GO:0007214)4.12068247
31positive regulation by organism of defense response of other organism involved in symbiotic interact4.11339208
32modulation by symbiont of host immune response (GO:0052553)4.11339208
33positive regulation by symbiont of host defense response (GO:0052509)4.11339208
34modulation by symbiont of host defense response (GO:0052031)4.11339208
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.11339208
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.11339208
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.03557397
38regulation of neuronal synaptic plasticity (GO:0048168)4.00996114
39regulation of long-term neuronal synaptic plasticity (GO:0048169)4.00272135
40postsynaptic membrane organization (GO:0001941)3.96613214
41exploration behavior (GO:0035640)3.94582819
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.92351912
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91352552
44negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.89934390
45positive regulation of membrane potential (GO:0045838)3.85451878
46gamma-aminobutyric acid transport (GO:0015812)3.80177272
47long-term synaptic potentiation (GO:0060291)3.74610087
48regulation of postsynaptic membrane potential (GO:0060078)3.72184014
49amino acid import (GO:0043090)3.71715865
50regulation of neurotransmitter secretion (GO:0046928)3.70438477
51sodium ion export (GO:0071436)3.69612008
52macrophage activation involved in immune response (GO:0002281)3.69361507
53dendritic spine morphogenesis (GO:0060997)3.67232743
54cerebellar Purkinje cell differentiation (GO:0021702)3.64652124
55neuron recognition (GO:0008038)3.62700249
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61793011
57neurotransmitter transport (GO:0006836)3.59263833
58regulation of synaptic plasticity (GO:0048167)3.58709194
59long-term memory (GO:0007616)3.52245881
60regulation of synapse structural plasticity (GO:0051823)3.52114234
61synaptic vesicle endocytosis (GO:0048488)3.51971680
62positive regulation of synapse maturation (GO:0090129)3.49384635
63layer formation in cerebral cortex (GO:0021819)3.48606551
64transmission of nerve impulse (GO:0019226)3.47752971
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.46638685
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.46043690
67axonal fasciculation (GO:0007413)3.42835485
68positive regulation of neurotransmitter secretion (GO:0001956)3.40717209
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.39288847
70regulation of B cell receptor signaling pathway (GO:0050855)3.37856752
71regulation of neurotransmitter transport (GO:0051588)3.36066152
72adult walking behavior (GO:0007628)3.34855036
73mechanosensory behavior (GO:0007638)3.34251074
74axon ensheathment in central nervous system (GO:0032291)3.32051449
75central nervous system myelination (GO:0022010)3.32051449
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.30895446
77auditory behavior (GO:0031223)3.29899181
78L-amino acid import (GO:0043092)3.29886658
79regulation of regulated secretory pathway (GO:1903305)3.29545377
80regulation of neurotransmitter levels (GO:0001505)3.28749928
81detection of other organism (GO:0098543)3.28475491
82regulation of dendritic spine morphogenesis (GO:0061001)3.26040352
83cellular potassium ion homeostasis (GO:0030007)3.24009448
84regulation of voltage-gated calcium channel activity (GO:1901385)3.23980627
85negative regulation of type 2 immune response (GO:0002829)3.23600474
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.23219136
87positive regulation of neurotransmitter transport (GO:0051590)3.21872587
88microglial cell activation (GO:0001774)3.21824721
89negative regulation of neurotransmitter transport (GO:0051589)3.21379962
90positive regulation of mast cell activation (GO:0033005)3.21297497
91response to histamine (GO:0034776)3.18862131
92regulation of vesicle fusion (GO:0031338)3.18022588
93neutrophil activation involved in immune response (GO:0002283)3.17869348
94membrane depolarization (GO:0051899)3.15050047
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14741127
96proline transport (GO:0015824)3.14301077
97neuromuscular process controlling posture (GO:0050884)3.14088207
98respiratory burst (GO:0045730)3.10012647
99membrane hyperpolarization (GO:0060081)3.09827813
100positive regulation of gamma-delta T cell activation (GO:0046645)3.09288956
101detection of bacterium (GO:0016045)3.06535654
102signal complex assembly (GO:0007172)3.05570836
103regulation of dendritic spine development (GO:0060998)3.05185875
104positive regulation of mast cell activation involved in immune response (GO:0033008)3.05140505
105positive regulation of mast cell degranulation (GO:0043306)3.05140505
106neuromuscular process controlling balance (GO:0050885)3.04550894
107positive regulation of synaptic transmission (GO:0050806)3.04157826
108regulation of synaptic transmission (GO:0050804)3.04106378
109G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03921760
110positive regulation of synapse assembly (GO:0051965)3.03751711
111cell differentiation in hindbrain (GO:0021533)3.00809403
112learning (GO:0007612)3.00282578
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97344710
114negative regulation of dendrite morphogenesis (GO:0050774)2.97272342
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.96656045
116synaptic transmission (GO:0007268)2.96142065
117regulation of respiratory system process (GO:0044065)2.96046930
118neurotransmitter uptake (GO:0001504)2.95899570
119synapse assembly (GO:0007416)2.95587598
120response to auditory stimulus (GO:0010996)2.95411270
121dendrite morphogenesis (GO:0048813)2.94092764
122activation of protein kinase A activity (GO:0034199)2.93851251
123positive regulation of Rap GTPase activity (GO:0032854)2.93270040
124neuronal ion channel clustering (GO:0045161)2.93053139
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92366656
126regulation of exocytosis (GO:0017157)2.92352196
127startle response (GO:0001964)2.91986212
128synaptic vesicle transport (GO:0048489)2.90368353
129establishment of synaptic vesicle localization (GO:0097480)2.90368353
130regulation of synapse maturation (GO:0090128)2.89938496
131detection of molecule of bacterial origin (GO:0032490)2.89206782
132regulation of glutamate secretion (GO:0014048)2.89199425
133behavioral response to cocaine (GO:0048148)2.89075566
134positive regulation of regulated secretory pathway (GO:1903307)2.88438236
135positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88345909
136positive regulation of dendritic spine morphogenesis (GO:0061003)2.82745546
137response to peptidoglycan (GO:0032494)2.81217469
138cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.81040855
139response to host immune response (GO:0052572)2.80868126
140response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.80868126
141detection of external biotic stimulus (GO:0098581)2.78060857
142negative regulation of lymphocyte mediated immunity (GO:0002707)2.76936147
143regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76729407
144regulation of mast cell degranulation (GO:0043304)2.74377358
145myeloid cell activation involved in immune response (GO:0002275)2.74048837
146regulation of T-helper 2 cell differentiation (GO:0045628)2.70249379
147positive regulation of dendritic spine development (GO:0060999)2.70230236
148vesicle docking involved in exocytosis (GO:0006904)2.68673701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.66285236
2GBX2_23144817_ChIP-Seq_PC3_Human4.09483969
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15983680
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07631718
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01415545
6THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.70886228
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69001868
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69001868
9REST_21632747_ChIP-Seq_MESCs_Mouse2.65808470
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58134726
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48067109
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.47660046
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.47657873
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.46861457
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44755043
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44589005
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43774758
18DROSHA_22980978_ChIP-Seq_HELA_Human2.36636762
19TAF15_26573619_Chip-Seq_HEK293_Human2.34606186
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.33698135
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.29342840
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.26984815
23RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.20748021
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.20020123
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19337784
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.15632881
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.12436461
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.10931772
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.99397916
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98276090
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95641017
32AR_21572438_ChIP-Seq_LNCaP_Human1.90434611
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88516285
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84346966
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83190558
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80452275
37IRF8_27001747_Chip-Seq_BMDM_Mouse1.80189946
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78642789
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77160270
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72055330
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.70222039
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65014818
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59009037
44P300_19829295_ChIP-Seq_ESCs_Human1.57463275
45GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.56073147
46SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.56053184
47KDM2B_26808549_Chip-Seq_K562_Human1.55622160
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53287659
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.49801012
50GATA1_26923725_Chip-Seq_HPCs_Mouse1.47945946
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47518269
52* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.47211211
53SPI1_23127762_ChIP-Seq_K562_Human1.45486039
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45442284
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44350209
56EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42831661
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.42133595
58SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41682924
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41498875
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.40435267
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.38535591
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37950710
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37597499
64EGR1_19032775_ChIP-ChIP_M12_Human1.35529130
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.33599888
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32936500
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32625924
68KDM2B_26808549_Chip-Seq_DND41_Human1.30048793
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29612031
70RNF2_27304074_Chip-Seq_NSC_Mouse1.29231757
71STAT3_23295773_ChIP-Seq_U87_Human1.28910870
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28882329
73AR_25329375_ChIP-Seq_VCAP_Human1.28490971
74FUS_26573619_Chip-Seq_HEK293_Human1.28332479
75TCF7_22412390_ChIP-Seq_EML_Mouse1.27772330
76OCT4_19829295_ChIP-Seq_ESCs_Human1.27727263
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27667573
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27350507
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.27346375
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.26585802
81ZNF274_21170338_ChIP-Seq_K562_Hela1.25905754
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24173845
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23753287
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22067424
85STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.20828131
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20199240
87TCF4_23295773_ChIP-Seq_U87_Human1.18589452
88* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.18071067
89ER_23166858_ChIP-Seq_MCF-7_Human1.16106471
90RING1B_27294783_Chip-Seq_ESCs_Mouse1.15883219
91* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15270784
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13848861
93PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10784277
94* AR_19668381_ChIP-Seq_PC3_Human1.10323214
95DPY_21335234_ChIP-Seq_ESCs_Mouse1.10212500
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09974660
97VDR_24763502_ChIP-Seq_THP-1_Human1.09776912
98KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.09696582
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09025135
100WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08626780
101VDR_22108803_ChIP-Seq_LS180_Human1.08307613
102* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08171527
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.06685919
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06185461
105TET1_21490601_ChIP-Seq_MESCs_Mouse1.06181822
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05673257
107ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05294088
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03896042
109MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02462451
110RING1B_27294783_Chip-Seq_NPCs_Mouse1.02418631
111AHR_22903824_ChIP-Seq_MCF-7_Human1.02236679
112YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01567399
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.01558061
114RUNX2_22187159_ChIP-Seq_PCA_Human1.00875617
115* SMAD4_21741376_ChIP-Seq_ESCs_Human1.00839163
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00800269
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00325677
118GATA1_19941827_ChIP-Seq_MEL_Mouse1.00285254
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99682206
120TP53_16413492_ChIP-PET_HCT116_Human0.99162947
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97842423
122LXR_22292898_ChIP-Seq_THP-1_Human0.97707865
123IGF1R_20145208_ChIP-Seq_DFB_Human0.96974638
124IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96546514
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96532483
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95462271
127RUNX1_22412390_ChIP-Seq_EML_Mouse0.95403204
128SOX9_26525672_Chip-Seq_HEART_Mouse0.93335945
129SMAD3_21741376_ChIP-Seq_ESCs_Human0.93219734
130JUN_21703547_ChIP-Seq_K562_Human0.93069339
131RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92825837
132SMC4_20622854_ChIP-Seq_HELA_Human0.92659653
133TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92158437
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92025024
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91290823
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90704124
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.90688342
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90654370
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90654370
140TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89742096
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89512458
142RXR_22108803_ChIP-Seq_LS180_Human0.89009876
143* KLF4_19829295_ChIP-Seq_ESCs_Human0.88933743
144MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88745788
145E2F1_18555785_Chip-Seq_ESCs_Mouse0.88617128
146WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88084887
147SPI1_23547873_ChIP-Seq_NB4_Human0.87948130
148RUNX_20019798_ChIP-Seq_JUKART_Human0.86657867
149GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85798243
150STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85206289
151PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84795554
152GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84387187
153VDR_21846776_ChIP-Seq_THP-1_Human0.84132398
154VDR_24787735_ChIP-Seq_THP-1_Human0.83152281
155OCT1_27270436_Chip-Seq_PROSTATE_Human0.82998343
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82677690
157PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81168758
158CTCF_27219007_Chip-Seq_Bcells_Human0.80900043
159SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80898042
160DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80896550
161TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80437596
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.78953766
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78618101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.11951427
2MP0003880_abnormal_central_pattern5.60571548
3MP0003635_abnormal_synaptic_transmissio4.10322763
4MP0004270_analgesia4.07558758
5MP0009046_muscle_twitch3.50245958
6MP0002064_seizures3.42503303
7MP0009745_abnormal_behavioral_response3.42106930
8MP0002063_abnormal_learning/memory/cond3.24832577
9MP0001968_abnormal_touch/_nociception3.01778518
10MP0002572_abnormal_emotion/affect_behav2.87074166
11MP0002272_abnormal_nervous_system2.86398906
12MP0001486_abnormal_startle_reflex2.76336796
13MP0002734_abnormal_mechanical_nocicepti2.72143908
14MP0005423_abnormal_somatic_nervous2.55278409
15MP0002736_abnormal_nociception_after2.48234851
16MP0001440_abnormal_grooming_behavior2.26533257
17MP0002067_abnormal_sensory_capabilities2.19371493
18MP0001501_abnormal_sleep_pattern2.16182480
19MP0003724_increased_susceptibility_to2.13602348
20MP0008569_lethality_at_weaning2.10504827
21MP0003303_peritoneal_inflammation2.06647573
22MP0000778_abnormal_nervous_system2.04553425
23MP0002735_abnormal_chemical_nociception2.01144025
24MP0002733_abnormal_thermal_nociception1.89686946
25MP0001970_abnormal_pain_threshold1.89400827
26MP0004924_abnormal_behavior1.85855290
27MP0005386_behavior/neurological_phenoty1.85855290
28MP0003787_abnormal_imprinting1.85388293
29MP0003329_amyloid_beta_deposits1.84107121
30MP0009780_abnormal_chondrocyte_physiolo1.78241764
31MP0001529_abnormal_vocalization1.72284151
32MP0002184_abnormal_innervation1.70642050
33MP0004811_abnormal_neuron_physiology1.70016681
34MP0002557_abnormal_social/conspecific_i1.67222067
35MP0004142_abnormal_muscle_tone1.67093267
36MP0005646_abnormal_pituitary_gland1.64102082
37MP0001905_abnormal_dopamine_level1.63533145
38MP0008260_abnormal_autophagy1.61598259
39MP0000955_abnormal_spinal_cord1.61177114
40MP0000920_abnormal_myelination1.59696128
41MP0003879_abnormal_hair_cell1.58184443
42MP0004885_abnormal_endolymph1.58099433
43MP0003436_decreased_susceptibility_to1.57412113
44MP0001835_abnormal_antigen_presentation1.56722194
45MP0003172_abnormal_lysosome_physiology1.55402158
46MP0002066_abnormal_motor_capabilities/c1.53075473
47MP0006276_abnormal_autonomic_nervous1.50750745
48MP0002882_abnormal_neuron_morphology1.49751813
49MP0002822_catalepsy1.49671412
50MP0002419_abnormal_innate_immunity1.40288135
51MP0003633_abnormal_nervous_system1.40056211
52MP0004742_abnormal_vestibular_system1.38025017
53MP0005671_abnormal_response_to1.33218508
54MP0003123_paternal_imprinting1.31540377
55MP0001984_abnormal_olfaction1.30633441
56MP0003631_nervous_system_phenotype1.29680001
57MP0003122_maternal_imprinting1.27236648
58MP0001986_abnormal_taste_sensitivity1.23457735
59MP0003690_abnormal_glial_cell1.20738762
60MP0001502_abnormal_circadian_rhythm1.20163623
61MP0005025_abnormal_response_to1.17716477
62MP0001800_abnormal_humoral_immune1.16540111
63MP0002229_neurodegeneration1.16515472
64MP0001188_hyperpigmentation1.16352903
65MP0002152_abnormal_brain_morphology1.15849249
66MP0004145_abnormal_muscle_electrophysio1.14068254
67MP0004858_abnormal_nervous_system1.12861841
68MP0001963_abnormal_hearing_physiology1.11636351
69MP0003632_abnormal_nervous_system1.10575967
70MP0005645_abnormal_hypothalamus_physiol1.09844436
71MP0006082_CNS_inflammation1.08661541
72MP0002909_abnormal_adrenal_gland1.08575501
73MP0001485_abnormal_pinna_reflex1.07329695
74MP0003634_abnormal_glial_cell1.03929200
75MP0002723_abnormal_immune_serum1.02449785
76* MP0001819_abnormal_immune_cell1.02259202
77* MP0002420_abnormal_adaptive_immunity1.01930333
78MP0005000_abnormal_immune_tolerance1.00767192
79MP0001790_abnormal_immune_system0.98175717
80MP0005387_immune_system_phenotype0.98175717
81MP0005310_abnormal_salivary_gland0.98138051
82MP0000751_myopathy0.96115839
83MP0000685_abnormal_immune_system0.95187900
84MP0002452_abnormal_antigen_presenting0.95180884
85MP0005166_decreased_susceptibility_to0.91796234
86MP0005171_absent_coat_pigmentation0.90685231
87MP0008872_abnormal_physiological_respon0.89677711
88MP0009785_altered_susceptibility_to0.88739138
89MP0005551_abnormal_eye_electrophysiolog0.87703374
90MP0008874_decreased_physiological_sensi0.86515814
91MP0004130_abnormal_muscle_cell0.86098990
92MP0002752_abnormal_somatic_nervous0.84670404
93MP0004510_myositis0.84388719
94MP0002069_abnormal_eating/drinking_beha0.84383221
95MP0009278_abnormal_bone_marrow0.84037223
96MP0003183_abnormal_peptide_metabolism0.82791038
97MP0003866_abnormal_defecation0.80163209
98MP0000631_abnormal_neuroendocrine_gland0.79111651
99MP0005623_abnormal_meninges_morphology0.76092703
100MP0001177_atelectasis0.75877389
101MP0000604_amyloidosis0.75105798
102MP0003191_abnormal_cellular_cholesterol0.70527916
103MP0001664_abnormal_digestion0.69851170
104MP0000716_abnormal_immune_system0.68909620
105MP0008877_abnormal_DNA_methylation0.67597788
106MP0003045_fibrosis0.67589630
107MP0004085_abnormal_heartbeat0.66808892
108MP0004043_abnormal_pH_regulation0.66617858
109MP0000569_abnormal_digit_pigmentation0.66125782
110MP0001533_abnormal_skeleton_physiology0.66123870
111MP0002148_abnormal_hypersensitivity_rea0.65848731
112MP0005394_taste/olfaction_phenotype0.65325544
113MP0005499_abnormal_olfactory_system0.65325544
114MP0002398_abnormal_bone_marrow0.64795949
115MP0001943_abnormal_respiration0.63694977
116MP0010386_abnormal_urinary_bladder0.63671509
117MP0001299_abnormal_eye_distance/0.63609239
118MP0005409_darkened_coat_color0.63425127
119MP0000026_abnormal_inner_ear0.62913392
120MP0004147_increased_porphyrin_level0.62307970
121MP0000013_abnormal_adipose_tissue0.61887295
122MP0002876_abnormal_thyroid_physiology0.61189940
123MP0003861_abnormal_nervous_system0.61055487
124MP0003075_altered_response_to0.61036526
125MP0002133_abnormal_respiratory_system0.60696479
126MP0005388_respiratory_system_phenotype0.60696479
127MP0005377_hearing/vestibular/ear_phenot0.59489701
128MP0003878_abnormal_ear_physiology0.59489701
129MP0010769_abnormal_survival0.58178550
130MP0002653_abnormal_ependyma_morphology0.57006642
131MP0002082_postnatal_lethality0.56776735
132MP0010770_preweaning_lethality0.56776735
133MP0004484_altered_response_of0.55820848
134MP0010768_mortality/aging0.55007435
135MP0003121_genomic_imprinting0.52810772
136MP0005535_abnormal_body_temperature0.52347283
137MP0003137_abnormal_impulse_conducting0.50442577
138MP0002090_abnormal_vision0.50347838

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.85717144
2Myokymia (HP:0002411)6.18441030
3Epileptic encephalopathy (HP:0200134)5.71916268
4Focal seizures (HP:0007359)5.56642195
5Atonic seizures (HP:0010819)5.55652097
6Visual hallucinations (HP:0002367)4.53516610
7Febrile seizures (HP:0002373)4.48811463
8Progressive cerebellar ataxia (HP:0002073)4.34593733
9Hyperventilation (HP:0002883)4.19169904
10Absence seizures (HP:0002121)4.17081646
11Broad-based gait (HP:0002136)4.01380604
12Dialeptic seizures (HP:0011146)3.95056380
13Recurrent bacterial skin infections (HP:0005406)3.89894816
14Gaze-evoked nystagmus (HP:0000640)3.82525699
15Eczematoid dermatitis (HP:0000976)3.65965036
16Recurrent abscess formation (HP:0002722)3.60381917
17Generalized tonic-clonic seizures (HP:0002069)3.60028958
18Action tremor (HP:0002345)3.59866055
19Dysmetria (HP:0001310)3.45947751
20Supranuclear gaze palsy (HP:0000605)3.37347802
21Hypochromic microcytic anemia (HP:0004840)3.30073474
22Abnormality of the corticospinal tract (HP:0002492)3.27378207
23Degeneration of the lateral corticospinal tracts (HP:0002314)3.27112210
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.27112210
25Impaired vibration sensation in the lower limbs (HP:0002166)3.23079743
26Ankle clonus (HP:0011448)3.20349555
27Scanning speech (HP:0002168)3.20070947
28Poor eye contact (HP:0000817)3.18115581
29Dysdiadochokinesis (HP:0002075)3.14500459
30Slow saccadic eye movements (HP:0000514)3.09113685
31Spastic gait (HP:0002064)3.07278780
32Abnormal eating behavior (HP:0100738)3.05465767
33Truncal ataxia (HP:0002078)3.00511039
34Urinary bladder sphincter dysfunction (HP:0002839)2.95754834
35Amyotrophic lateral sclerosis (HP:0007354)2.91808657
36Abnormality of macrophages (HP:0004311)2.86357917
37Amblyopia (HP:0000646)2.84869551
38Annular pancreas (HP:0001734)2.81385659
39Insidious onset (HP:0003587)2.80887289
40Termporal pattern (HP:0011008)2.80887289
41Depression (HP:0000716)2.80493670
42Sensory axonal neuropathy (HP:0003390)2.80222330
43Retrobulbar optic neuritis (HP:0100654)2.78782569
44Optic neuritis (HP:0100653)2.78782569
45Excessive salivation (HP:0003781)2.77118540
46Drooling (HP:0002307)2.77118540
47Orchitis (HP:0100796)2.76906928
48Neurofibrillary tangles (HP:0002185)2.74584698
49Intention tremor (HP:0002080)2.72840810
50Myositis (HP:0100614)2.71970302
51Abnormal social behavior (HP:0012433)2.69367193
52Impaired social interactions (HP:0000735)2.69367193
53Urinary urgency (HP:0000012)2.64271052
54Pheochromocytoma (HP:0002666)2.58433658
55Memory impairment (HP:0002354)2.58058175
56Recurrent gram-negative bacterial infections (HP:0005420)2.57391603
57Obstructive sleep apnea (HP:0002870)2.56309851
58Anxiety (HP:0000739)2.55649377
59Fetal akinesia sequence (HP:0001989)2.55319644
60Agnosia (HP:0010524)2.55230072
61Hypochromic anemia (HP:0001931)2.53786965
62Impaired smooth pursuit (HP:0007772)2.52651951
63Postural instability (HP:0002172)2.52390189
64Cerebral inclusion bodies (HP:0100314)2.50754029
65Dysmetric saccades (HP:0000641)2.50249301
66Genetic anticipation (HP:0003743)2.48776214
67Progressive inability to walk (HP:0002505)2.47726811
68Tetraplegia (HP:0002445)2.46298887
69Abnormality of binocular vision (HP:0011514)2.46138641
70Diplopia (HP:0000651)2.46138641
71Urticaria (HP:0001025)2.45487078
72Chronic obstructive pulmonary disease (HP:0006510)2.44902793
73Obstructive lung disease (HP:0006536)2.44902793
74Epileptiform EEG discharges (HP:0011182)2.44892045
75Mutism (HP:0002300)2.44665753
76Amyloidosis (HP:0011034)2.41833904
77Akinesia (HP:0002304)2.40584978
78Absent speech (HP:0001344)2.39157547
79Apathy (HP:0000741)2.38156389
80Papilledema (HP:0001085)2.35593574
81Polyphagia (HP:0002591)2.34778518
82Stereotypic behavior (HP:0000733)2.32183765
83Inability to walk (HP:0002540)2.31522857
84Generalized myoclonic seizures (HP:0002123)2.28429454
85Megalencephaly (HP:0001355)2.27975477
86Mediastinal lymphadenopathy (HP:0100721)2.27916751
87Neuroendocrine neoplasm (HP:0100634)2.27266670
88Gingivitis (HP:0000230)2.27158531
89Abnormal hair whorl (HP:0010721)2.26609969
90Impaired vibratory sensation (HP:0002495)2.26290265
91Protruding tongue (HP:0010808)2.26124699
92Inappropriate behavior (HP:0000719)2.23741480
93Thickened helices (HP:0000391)2.23524930
94Meningitis (HP:0001287)2.22791237
95Diminished motivation (HP:0000745)2.22201200
96Hemiparesis (HP:0001269)2.21578643
97Lower limb muscle weakness (HP:0007340)2.20456174
98Recurrent skin infections (HP:0001581)2.19540689
99EEG with generalized epileptiform discharges (HP:0011198)2.17674012
100Abnormality of ocular smooth pursuit (HP:0000617)2.17673244
101Rigidity (HP:0002063)2.17540207
102Gait imbalance (HP:0002141)2.15478694
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14399928
104Specific learning disability (HP:0001328)2.13792238
105Limb dystonia (HP:0002451)2.13051039
106Chest pain (HP:0100749)2.11686853
107Ventricular fibrillation (HP:0001663)2.10282205
108Bradykinesia (HP:0002067)2.10151868
109Peripheral hypomyelination (HP:0007182)2.08249493
110Stomatitis (HP:0010280)2.08055905
111Disinhibition (HP:0000734)2.07848721
112Abnormal delayed hypersensitivity skin test (HP:0002963)2.07803875
113Gastrointestinal infarctions (HP:0005244)2.07460097
114Hypsarrhythmia (HP:0002521)2.06695475
115Torticollis (HP:0000473)2.05585123
116Spastic tetraparesis (HP:0001285)2.03899885
117Incomplete penetrance (HP:0003829)2.03870479
118Abnormality of saccadic eye movements (HP:0000570)2.02870080
119Gait ataxia (HP:0002066)2.02533539
120Blue irides (HP:0000635)2.02506531
121Focal dystonia (HP:0004373)1.99800908
122Abnormality of the lower motor neuron (HP:0002366)1.99100535
123Sleep apnea (HP:0010535)1.97484958
124Abnormality of the labia minora (HP:0012880)1.97468492
125Abnormality of salivation (HP:0100755)1.95774665
126Keratoconjunctivitis sicca (HP:0001097)1.93752106
127Status epilepticus (HP:0002133)1.93386479
128Hemiplegia (HP:0002301)1.91841198
129Cerebral hypomyelination (HP:0006808)1.90029068
130Cellulitis (HP:0100658)1.89167688
131Rapidly progressive (HP:0003678)1.88847087
132Dementia (HP:0000726)1.88356795
133Failure to thrive in infancy (HP:0001531)1.84210697
134Clumsiness (HP:0002312)1.82874473
135Neuronal loss in central nervous system (HP:0002529)1.81109553
136Congenital primary aphakia (HP:0007707)1.80190724
137Delusions (HP:0000746)1.76596504
138Clonus (HP:0002169)1.75666096
139Psychosis (HP:0000709)1.74517966
140Retinal dysplasia (HP:0007973)1.73408386
141Postural tremor (HP:0002174)1.70720730
142Craniofacial dystonia (HP:0012179)1.70243128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.91089859
2EPHA43.73145032
3NTRK33.66985587
4MAP3K93.35068578
5MAP3K43.17987826
6MAP2K72.89059683
7DAPK22.86523651
8MAP3K122.85311989
9MARK12.46867938
10MINK12.31697906
11PAK62.27123492
12PRPF4B2.22738189
13MAP2K41.98068754
14PLK21.95935271
15DAPK11.92134819
16TNIK1.77634233
17NTRK21.66053931
18MAP3K111.65504216
19CCNB11.64820854
20STK391.60831344
21CAMKK21.58654232
22CAMKK11.53852656
23KSR21.51263117
24KSR11.50183337
25BLK1.47187829
26PNCK1.46481252
27* CDK51.46277914
28RIPK41.45808296
29UHMK11.40777974
30NTRK11.34572067
31GRK51.31189667
32MAPK131.28236819
33ARAF1.27122054
34BCR1.25432951
35SGK2231.21227671
36SGK4941.21227671
37CAMK2B1.20794896
38MAP2K31.19110813
39CSK1.17852285
40PRKCG1.14957767
41MAP4K11.13055683
42CAMK2A1.11153354
43PRKD31.09994458
44IRAK41.09369490
45AKT31.04599229
46MAPK121.03279835
47MAP3K11.01763938
48TYRO31.01599079
49* CDK180.99848270
50CAMK1G0.98995520
51SYK0.96272996
52* CDK150.94742163
53* CDK140.94720975
54FES0.88638894
55* JAK20.86847342
56WNK10.86237571
57CSNK1G20.84850670
58MAP3K130.84436389
59PTK2B0.84368012
60TYK20.83630845
61* CDK11A0.82124476
62BMPR20.80956206
63CAMK10.80943639
64FGR0.79829051
65GRK60.77806546
66CSF1R0.77133131
67PRKCZ0.77027601
68NEK60.76829154
69SGK20.75976808
70MAP3K20.75573925
71SIK30.74383852
72STK380.73668796
73ROCK20.73103300
74PAK30.70961945
75YES10.69511155
76RIPK10.69230571
77* OXSR10.68801690
78CAMK2D0.68799416
79FGFR20.68141091
80HCK0.67887685
81DYRK1A0.66950256
82CAMK2G0.66143376
83PHKG20.63890290
84PHKG10.63890290
85DAPK30.63718695
86SGK10.63578454
87MAPKAPK50.63094919
88SIK20.62009108
89BRAF0.61741258
90PRKCH0.61559361
91MARK20.61233544
92IRAK20.59464125
93JAK10.59184016
94SGK30.59122333
95RAF10.57623516
96NME10.57218441
97TAOK20.56914585
98PKN10.56205986
99PRKCE0.56151123
100LIMK10.55937429
101RET0.55264140
102ZAP700.55162914
103TAOK10.54396215
104CAMK1D0.53741844
105MAP3K70.52901409
106* STK110.51173463
107MAP3K50.51129072
108MAP2K60.50107400
109WNK40.49991026
110TNK20.48692746
111LYN0.47813002
112CSNK1G30.47724971
113EPHB10.47591773
114FYN0.47329064
115MAP3K60.47096025
116BTK0.46893872
117DYRK1B0.45279160
118CAMK40.44719087
119TSSK60.43544907
120PRKG20.43133452
121WNK30.42440544
122PINK10.41418590
123RPS6KA30.40595941
124MAPK70.39380646
125ALK0.38762821
126* PDK10.38097388
127ADRBK10.37857601
128LATS20.37725265
129MAPK100.37334955
130* PDPK10.34840261
131CSNK1A1L0.34355871

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.02934551
2Synaptic vesicle cycle_Homo sapiens_hsa047213.82852199
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80765873
4Long-term potentiation_Homo sapiens_hsa047202.68438664
5Circadian entrainment_Homo sapiens_hsa047132.64882194
6GABAergic synapse_Homo sapiens_hsa047272.64716805
7Glutamatergic synapse_Homo sapiens_hsa047242.64293147
8Olfactory transduction_Homo sapiens_hsa047402.60009936
9Morphine addiction_Homo sapiens_hsa050322.56305613
10Amphetamine addiction_Homo sapiens_hsa050312.47925097
11Collecting duct acid secretion_Homo sapiens_hsa049662.35436116
12Salivary secretion_Homo sapiens_hsa049702.17335913
13Dopaminergic synapse_Homo sapiens_hsa047282.14120716
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92015438
15Long-term depression_Homo sapiens_hsa047301.91218928
16Gastric acid secretion_Homo sapiens_hsa049711.87387504
17Insulin secretion_Homo sapiens_hsa049111.82358850
18Taste transduction_Homo sapiens_hsa047421.81977075
19Serotonergic synapse_Homo sapiens_hsa047261.77099507
20Cholinergic synapse_Homo sapiens_hsa047251.73252389
21Leishmaniasis_Homo sapiens_hsa051401.70316351
22Renin secretion_Homo sapiens_hsa049241.62528705
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60899484
24Oxytocin signaling pathway_Homo sapiens_hsa049211.59361010
25Vibrio cholerae infection_Homo sapiens_hsa051101.54336515
26Tuberculosis_Homo sapiens_hsa051521.53337587
27Cocaine addiction_Homo sapiens_hsa050301.52133425
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49714454
29Calcium signaling pathway_Homo sapiens_hsa040201.49053502
30Allograft rejection_Homo sapiens_hsa053301.43233556
31Osteoclast differentiation_Homo sapiens_hsa043801.42664851
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41825237
33Type I diabetes mellitus_Homo sapiens_hsa049401.39593939
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34059170
35Graft-versus-host disease_Homo sapiens_hsa053321.33505903
36GnRH signaling pathway_Homo sapiens_hsa049121.32330919
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31779984
38Autoimmune thyroid disease_Homo sapiens_hsa053201.31756913
39Gap junction_Homo sapiens_hsa045401.31193580
40* Axon guidance_Homo sapiens_hsa043601.30396714
41B cell receptor signaling pathway_Homo sapiens_hsa046621.28870817
42* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.21074547
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18500884
44* cAMP signaling pathway_Homo sapiens_hsa040241.16786289
45* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15873236
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14976380
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13790506
48Staphylococcus aureus infection_Homo sapiens_hsa051501.13199597
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08446169
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03806888
51* ErbB signaling pathway_Homo sapiens_hsa040121.02453142
52Estrogen signaling pathway_Homo sapiens_hsa049151.00737107
53Glioma_Homo sapiens_hsa052140.93066516
54Melanogenesis_Homo sapiens_hsa049160.92949392
55Type II diabetes mellitus_Homo sapiens_hsa049300.92297072
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90286744
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89655205
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.89415802
59Asthma_Homo sapiens_hsa053100.89182616
60Cardiac muscle contraction_Homo sapiens_hsa042600.88234145
61Oocyte meiosis_Homo sapiens_hsa041140.86846659
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82467571
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81117815
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.79123592
65Viral myocarditis_Homo sapiens_hsa054160.78223174
66Phototransduction_Homo sapiens_hsa047440.77458753
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77171560
68Pancreatic secretion_Homo sapiens_hsa049720.76836060
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.76295251
70Dorso-ventral axis formation_Homo sapiens_hsa043200.75965840
71Oxidative phosphorylation_Homo sapiens_hsa001900.72971311
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72769409
73* MAPK signaling pathway_Homo sapiens_hsa040100.72696823
74Influenza A_Homo sapiens_hsa051640.71980173
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71631279
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71505464
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71172472
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68666751
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68069035
80Salmonella infection_Homo sapiens_hsa051320.65836601
81Rheumatoid arthritis_Homo sapiens_hsa053230.65250445
82Inositol phosphate metabolism_Homo sapiens_hsa005620.65112265
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65003788
84* Ras signaling pathway_Homo sapiens_hsa040140.64962769
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.64931769
86Alzheimers disease_Homo sapiens_hsa050100.63674145
87Thyroid hormone synthesis_Homo sapiens_hsa049180.63632008
88Choline metabolism in cancer_Homo sapiens_hsa052310.62118954
89Endocytosis_Homo sapiens_hsa041440.60036668
90Toxoplasmosis_Homo sapiens_hsa051450.56643955
91Intestinal immune network for IgA production_Homo sapiens_hsa046720.56365534
92Antigen processing and presentation_Homo sapiens_hsa046120.55913223
93Dilated cardiomyopathy_Homo sapiens_hsa054140.55323511
94Platelet activation_Homo sapiens_hsa046110.53598252
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52579037
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52426273
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52298009
98Rap1 signaling pathway_Homo sapiens_hsa040150.51815041
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51571096
100Endometrial cancer_Homo sapiens_hsa052130.51557080
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.51457837
102Circadian rhythm_Homo sapiens_hsa047100.50268722
103Alcoholism_Homo sapiens_hsa050340.48945890
104VEGF signaling pathway_Homo sapiens_hsa043700.48890712
105Wnt signaling pathway_Homo sapiens_hsa043100.48668418
106Prolactin signaling pathway_Homo sapiens_hsa049170.47665266
107Phagosome_Homo sapiens_hsa041450.47229726
108* T cell receptor signaling pathway_Homo sapiens_hsa046600.46561778
109Legionellosis_Homo sapiens_hsa051340.45564812
110Ether lipid metabolism_Homo sapiens_hsa005650.45383567
111Acute myeloid leukemia_Homo sapiens_hsa052210.43802569
112Regulation of autophagy_Homo sapiens_hsa041400.43704751
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42936548
114* Renal cell carcinoma_Homo sapiens_hsa052110.42913011
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42050310
116Ovarian steroidogenesis_Homo sapiens_hsa049130.36616853
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36217738
118Parkinsons disease_Homo sapiens_hsa050120.34506137
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33357075
120Tight junction_Homo sapiens_hsa045300.31242733
121Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31111984
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30349103
123Glucagon signaling pathway_Homo sapiens_hsa049220.30068253
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29080148
125African trypanosomiasis_Homo sapiens_hsa051430.28860872
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27108917
127* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26731110
128* Chemokine signaling pathway_Homo sapiens_hsa040620.25779379
129Non-small cell lung cancer_Homo sapiens_hsa052230.25251922
130Nitrogen metabolism_Homo sapiens_hsa009100.24775223
131* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24153291
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23889581

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