Rank | Gene Set | Z-score |
---|---|---|
1 | maturation of SSU-rRNA (GO:0030490) | 4.92505530 |
2 | proteasome assembly (GO:0043248) | 4.69463219 |
3 | purine nucleobase biosynthetic process (GO:0009113) | 4.54291956 |
4 | nucleobase biosynthetic process (GO:0046112) | 4.45227597 |
5 | formation of translation preinitiation complex (GO:0001731) | 4.36857004 |
6 | mitotic metaphase plate congression (GO:0007080) | 4.36647216 |
7 | chaperone-mediated protein transport (GO:0072321) | 4.36505556 |
8 | establishment of integrated proviral latency (GO:0075713) | 4.33552431 |
9 | DNA replication checkpoint (GO:0000076) | 4.31796174 |
10 | ribosome biogenesis (GO:0042254) | 4.19930221 |
11 | DNA replication initiation (GO:0006270) | 4.15061250 |
12 | ribosome assembly (GO:0042255) | 4.11818389 |
13 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.11288580 |
14 | CENP-A containing nucleosome assembly (GO:0034080) | 4.07598408 |
15 | DNA deamination (GO:0045006) | 3.99880485 |
16 | ribosomal small subunit assembly (GO:0000028) | 3.98254442 |
17 | chromatin remodeling at centromere (GO:0031055) | 3.97314428 |
18 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.96587959 |
19 | rRNA modification (GO:0000154) | 3.95037764 |
20 | DNA double-strand break processing (GO:0000729) | 3.94665146 |
21 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.93437297 |
22 | maturation of 5.8S rRNA (GO:0000460) | 3.92780005 |
23 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.91297890 |
24 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.90938308 |
25 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.89575368 |
26 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.88709574 |
27 | cullin deneddylation (GO:0010388) | 3.81287716 |
28 | protein deneddylation (GO:0000338) | 3.78676412 |
29 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.75701560 |
30 | termination of RNA polymerase III transcription (GO:0006386) | 3.75701560 |
31 | ribosomal large subunit biogenesis (GO:0042273) | 3.75590014 |
32 | 7-methylguanosine mRNA capping (GO:0006370) | 3.74827615 |
33 | DNA strand elongation (GO:0022616) | 3.74624151 |
34 | metaphase plate congression (GO:0051310) | 3.74081075 |
35 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.70399949 |
36 | regulation of mitochondrial translation (GO:0070129) | 3.69560542 |
37 | transcription from mitochondrial promoter (GO:0006390) | 3.69311962 |
38 | rRNA processing (GO:0006364) | 3.67123661 |
39 | 7-methylguanosine RNA capping (GO:0009452) | 3.66996406 |
40 | RNA capping (GO:0036260) | 3.66996406 |
41 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.56745997 |
42 | negative regulation of ligase activity (GO:0051352) | 3.56745997 |
43 | ribosomal small subunit biogenesis (GO:0042274) | 3.54265063 |
44 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.54168245 |
45 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.54168245 |
46 | rRNA metabolic process (GO:0016072) | 3.54002417 |
47 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.52171952 |
48 | mitochondrial RNA metabolic process (GO:0000959) | 3.51203779 |
49 | telomere maintenance via recombination (GO:0000722) | 3.50289234 |
50 | termination of RNA polymerase I transcription (GO:0006363) | 3.49164042 |
51 | DNA replication-independent nucleosome organization (GO:0034724) | 3.48649861 |
52 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.48649861 |
53 | protein localization to kinetochore (GO:0034501) | 3.48066159 |
54 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.48048398 |
55 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.47445278 |
56 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.44860800 |
57 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.41883715 |
58 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.41761938 |
59 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.41761938 |
60 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.41709936 |
61 | ATP synthesis coupled proton transport (GO:0015986) | 3.41709936 |
62 | negative regulation of DNA-dependent DNA replication (GO:2000104) | 3.41295406 |
63 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.41042347 |
64 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.41042347 |
65 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.41042347 |
66 | mitotic nuclear envelope disassembly (GO:0007077) | 3.40596014 |
67 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.40091321 |
68 | establishment of viral latency (GO:0019043) | 3.37660220 |
69 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.37365012 |
70 | rRNA methylation (GO:0031167) | 3.37166783 |
71 | respiratory chain complex IV assembly (GO:0008535) | 3.37081279 |
72 | spliceosomal snRNP assembly (GO:0000387) | 3.36407465 |
73 | protein targeting to mitochondrion (GO:0006626) | 3.35525972 |
74 | histone exchange (GO:0043486) | 3.35321197 |
75 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.35165786 |
76 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.35165786 |
77 | positive regulation of ligase activity (GO:0051351) | 3.34496318 |
78 | transcription from RNA polymerase I promoter (GO:0006360) | 3.33147659 |
79 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.31760750 |
80 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.30567138 |
81 | establishment of chromosome localization (GO:0051303) | 3.30325943 |
82 | DNA damage response, detection of DNA damage (GO:0042769) | 3.30294030 |
83 | IMP biosynthetic process (GO:0006188) | 3.29551095 |
84 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.27893921 |
85 | cell cycle G1/S phase transition (GO:0044843) | 3.27893921 |
86 | mitotic recombination (GO:0006312) | 3.26936077 |
87 | spindle checkpoint (GO:0031577) | 3.25159877 |
88 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.24468387 |
89 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.22889568 |
90 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.22889568 |
91 | pseudouridine synthesis (GO:0001522) | 3.22767789 |
92 | protein complex biogenesis (GO:0070271) | 3.20938889 |
93 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.20662302 |
94 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.18941918 |
95 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.18941918 |
96 | isotype switching (GO:0045190) | 3.18941918 |
97 | regulation of spindle organization (GO:0090224) | 3.18013823 |
98 | translational initiation (GO:0006413) | 3.16878728 |
99 | histone mRNA metabolic process (GO:0008334) | 3.16737232 |
100 | kinetochore organization (GO:0051383) | 3.16723777 |
101 | tRNA aminoacylation (GO:0043039) | 3.16717454 |
102 | amino acid activation (GO:0043038) | 3.16717454 |
103 | cellular component biogenesis (GO:0044085) | 3.15386215 |
104 | tRNA aminoacylation for protein translation (GO:0006418) | 3.15146982 |
105 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.14944392 |
106 | NADH dehydrogenase complex assembly (GO:0010257) | 3.14836940 |
107 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.14836940 |
108 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.14836940 |
109 | replication fork processing (GO:0031297) | 3.14782881 |
110 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.14529507 |
111 | mitotic spindle checkpoint (GO:0071174) | 3.14189181 |
112 | translational termination (GO:0006415) | 3.14035334 |
113 | nuclear envelope disassembly (GO:0051081) | 3.13876668 |
114 | membrane disassembly (GO:0030397) | 3.13876668 |
115 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.10783861 |
116 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.10783861 |
117 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.10783861 |
118 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.10783861 |
119 | negative regulation of sister chromatid segregation (GO:0033046) | 3.10783861 |
120 | viral transcription (GO:0019083) | 3.10328171 |
121 | telomere maintenance via telomere lengthening (GO:0010833) | 3.10071531 |
122 | protein neddylation (GO:0045116) | 3.09971303 |
123 | viral mRNA export from host cell nucleus (GO:0046784) | 3.09476247 |
124 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.09147565 |
125 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.07807005 |
126 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.07599787 |
127 | DNA unwinding involved in DNA replication (GO:0006268) | 3.05948370 |
128 | nuclear pore organization (GO:0006999) | 3.04555958 |
129 | IMP metabolic process (GO:0046040) | 3.03671091 |
130 | kinetochore assembly (GO:0051382) | 3.01367371 |
131 | folic acid metabolic process (GO:0046655) | 2.99464353 |
132 | protein K6-linked ubiquitination (GO:0085020) | 2.99041649 |
133 | transcription elongation from RNA polymerase II promoter (GO:0006368) | 2.98770493 |
134 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 2.96597445 |
135 | regulation of ligase activity (GO:0051340) | 2.96169403 |
136 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.95827302 |
137 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 2.94558138 |
138 | folic acid-containing compound biosynthetic process (GO:0009396) | 2.92534268 |
139 | DNA-templated transcription, elongation (GO:0006354) | 2.91552069 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.11019734 |
2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.47008904 |
3 | * KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.01890514 |
4 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.69430621 |
5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.61018568 |
6 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.58441713 |
7 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.54190685 |
8 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.33315279 |
9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.26710842 |
10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.12707291 |
11 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.98990275 |
12 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.96891747 |
13 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.95591884 |
14 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.95583097 |
15 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.83735199 |
16 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.74586087 |
17 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.61325869 |
18 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.60530912 |
19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.60400558 |
20 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.53035302 |
21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.37988243 |
22 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.36752572 |
23 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.29471380 |
24 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.27168791 |
25 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.26845380 |
26 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.22634543 |
27 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.16201607 |
28 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.07642169 |
29 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.06679689 |
30 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.04882923 |
31 | * ELK1_19687146_ChIP-ChIP_HELA_Human | 2.01919867 |
32 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.00975273 |
33 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.00115502 |
34 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.98276350 |
35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.97653954 |
36 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.91991870 |
37 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.90612163 |
38 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.89946055 |
39 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.89179060 |
40 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.84018630 |
41 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.83875628 |
42 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.82501087 |
43 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.82186838 |
44 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.76207157 |
45 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.73263292 |
46 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.72996715 |
47 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.70539224 |
48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.64349824 |
49 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.64101537 |
50 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.58347882 |
51 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.58208804 |
52 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.53691352 |
53 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.53661837 |
54 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.47323657 |
55 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.41830046 |
56 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.41351625 |
57 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.37974280 |
58 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.35888019 |
59 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.35111958 |
60 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.33786721 |
61 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.32497563 |
62 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.26563286 |
63 | EWS_26573619_Chip-Seq_HEK293_Human | 1.26447287 |
64 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.24342033 |
65 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.22406458 |
66 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.21787466 |
67 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.21197333 |
68 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20353474 |
69 | VDR_22108803_ChIP-Seq_LS180_Human | 1.17873815 |
70 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.16724824 |
71 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.16479346 |
72 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.15925799 |
73 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.13990455 |
74 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.13257979 |
75 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.10688176 |
76 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.10280995 |
77 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.10191189 |
78 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.09987150 |
79 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.09610097 |
80 | * MYC_18940864_ChIP-ChIP_HL60_Human | 1.09377624 |
81 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.08534076 |
82 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.06629963 |
83 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03685908 |
84 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.02822003 |
85 | FUS_26573619_Chip-Seq_HEK293_Human | 1.01998789 |
86 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.00060590 |
87 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.98031507 |
88 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.98010534 |
89 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.97136923 |
90 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97037939 |
91 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.96934406 |
92 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.94106123 |
93 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.91679133 |
94 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.91355609 |
95 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.90929973 |
96 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.88821285 |
97 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.87856229 |
98 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.87594296 |
99 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.85348681 |
100 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.85109143 |
101 | * CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84998227 |
102 | * GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.83313173 |
103 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.82230040 |
104 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.82223682 |
105 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.80346338 |
106 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.78589521 |
107 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 0.78562713 |
108 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.77551855 |
109 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.77294561 |
110 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.77212904 |
111 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.76768807 |
112 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.76419064 |
113 | * SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.74597663 |
114 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.74451156 |
115 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 0.73794699 |
116 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.73665819 |
117 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.73442523 |
118 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.72535155 |
119 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.68138434 |
120 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.65725348 |
121 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.65121505 |
122 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.64185832 |
123 | P300_19829295_ChIP-Seq_ESCs_Human | 0.61427991 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0003693_abnormal_embryo_hatching | 6.28682867 |
2 | MP0010094_abnormal_chromosome_stability | 4.85140720 |
3 | MP0004957_abnormal_blastocyst_morpholog | 4.80378295 |
4 | MP0003111_abnormal_nucleus_morphology | 4.30423167 |
5 | MP0003077_abnormal_cell_cycle | 4.00330842 |
6 | MP0008058_abnormal_DNA_repair | 3.91662902 |
7 | MP0008057_abnormal_DNA_replication | 3.40831037 |
8 | MP0008877_abnormal_DNA_methylation | 3.17041814 |
9 | MP0003718_maternal_effect | 2.99738034 |
10 | MP0008932_abnormal_embryonic_tissue | 2.93637971 |
11 | MP0003786_premature_aging | 2.93162449 |
12 | MP0008007_abnormal_cellular_replicative | 2.86878960 |
13 | MP0003123_paternal_imprinting | 2.53186203 |
14 | MP0003806_abnormal_nucleotide_metabolis | 2.15935020 |
15 | MP0002396_abnormal_hematopoietic_system | 2.10369989 |
16 | MP0001730_embryonic_growth_arrest | 2.08051836 |
17 | MP0000350_abnormal_cell_proliferation | 1.99327206 |
18 | MP0009333_abnormal_splenocyte_physiolog | 1.90280541 |
19 | MP0002102_abnormal_ear_morphology | 1.81195903 |
20 | MP0003186_abnormal_redox_activity | 1.78338219 |
21 | MP0002210_abnormal_sex_determination | 1.64948055 |
22 | MP0006072_abnormal_retinal_apoptosis | 1.63240624 |
23 | MP0000490_abnormal_crypts_of | 1.62869028 |
24 | MP0008260_abnormal_autophagy | 1.62632698 |
25 | MP0002938_white_spotting | 1.56147680 |
26 | MP0004147_increased_porphyrin_level | 1.54244294 |
27 | MP0006292_abnormal_olfactory_placode | 1.53293162 |
28 | MP0003890_abnormal_embryonic-extraembry | 1.50744909 |
29 | MP0010307_abnormal_tumor_latency | 1.49215417 |
30 | MP0001697_abnormal_embryo_size | 1.46346195 |
31 | MP0000313_abnormal_cell_death | 1.43081325 |
32 | MP0005380_embryogenesis_phenotype | 1.40419217 |
33 | MP0001672_abnormal_embryogenesis/_devel | 1.40419217 |
34 | MP0002019_abnormal_tumor_incidence | 1.38973769 |
35 | MP0002080_prenatal_lethality | 1.37871075 |
36 | MP0002132_abnormal_respiratory_system | 1.36785954 |
37 | MP0003763_abnormal_thymus_physiology | 1.36378521 |
38 | MP0008789_abnormal_olfactory_epithelium | 1.36251036 |
39 | MP0003315_abnormal_perineum_morphology | 1.34815419 |
40 | MP0001145_abnormal_male_reproductive | 1.33326462 |
41 | MP0003195_calcinosis | 1.31822325 |
42 | MP0010352_gastrointestinal_tract_polyps | 1.29821967 |
43 | MP0001929_abnormal_gametogenesis | 1.28128149 |
44 | MP0005171_absent_coat_pigmentation | 1.28115037 |
45 | MP0000653_abnormal_sex_gland | 1.27343676 |
46 | MP0001119_abnormal_female_reproductive | 1.25388231 |
47 | MP0001542_abnormal_bone_strength | 1.21197432 |
48 | MP0003984_embryonic_growth_retardation | 1.20727041 |
49 | MP0005397_hematopoietic_system_phenotyp | 1.18918864 |
50 | MP0001545_abnormal_hematopoietic_system | 1.18918864 |
51 | MP0004808_abnormal_hematopoietic_stem | 1.18035137 |
52 | MP0002088_abnormal_embryonic_growth/wei | 1.16649014 |
53 | MP0009379_abnormal_foot_pigmentation | 1.15682253 |
54 | MP0005075_abnormal_melanosome_morpholog | 1.14599366 |
55 | MP0003136_yellow_coat_color | 1.13315431 |
56 | MP0009697_abnormal_copulation | 1.13255374 |
57 | MP0006036_abnormal_mitochondrial_physio | 1.11871261 |
58 | MP0002398_abnormal_bone_marrow | 1.08910517 |
59 | MP0002160_abnormal_reproductive_system | 1.08563375 |
60 | MP0003937_abnormal_limbs/digits/tail_de | 1.08177989 |
61 | MP0003121_genomic_imprinting | 1.07683773 |
62 | MP0002085_abnormal_embryonic_tissue | 1.04904066 |
63 | MP0001188_hyperpigmentation | 1.02587592 |
64 | MP0005389_reproductive_system_phenotype | 1.02478069 |
65 | MP0000689_abnormal_spleen_morphology | 1.02401741 |
66 | MP0008995_early_reproductive_senescence | 1.01835405 |
67 | MP0000358_abnormal_cell_content/ | 1.01435925 |
68 | MP0002086_abnormal_extraembryonic_tissu | 1.00647624 |
69 | MP0001764_abnormal_homeostasis | 1.00041913 |
70 | MP0005671_abnormal_response_to | 0.99726308 |
71 | MP0002722_abnormal_immune_system | 0.99060782 |
72 | MP0000858_altered_metastatic_potential | 0.97713228 |
73 | MP0003567_abnormal_fetal_cardiomyocyte | 0.97513585 |
74 | MP0006035_abnormal_mitochondrial_morpho | 0.96253984 |
75 | MP0002254_reproductive_system_inflammat | 0.94546759 |
76 | MP0000703_abnormal_thymus_morphology | 0.92756981 |
77 | MP0001853_heart_inflammation | 0.91620997 |
78 | MP0002090_abnormal_vision | 0.91567224 |
79 | MP0002429_abnormal_blood_cell | 0.90492486 |
80 | MP0005253_abnormal_eye_physiology | 0.90013532 |
81 | MP0000647_abnormal_sebaceous_gland | 0.88439807 |
82 | MP0003646_muscle_fatigue | 0.88171110 |
83 | MP0002736_abnormal_nociception_after | 0.87847127 |
84 | MP0009785_altered_susceptibility_to | 0.87632702 |
85 | MP0002084_abnormal_developmental_patter | 0.87364608 |
86 | MP0004215_abnormal_myocardial_fiber | 0.85135487 |
87 | MP0002653_abnormal_ependyma_morphology | 0.85126297 |
88 | MP0009672_abnormal_birth_weight | 0.83804898 |
89 | MP0001835_abnormal_antigen_presentation | 0.83315148 |
90 | MP0005395_other_phenotype | 0.82937487 |
91 | MP0005408_hypopigmentation | 0.82533009 |
92 | MP0003941_abnormal_skin_development | 0.82488005 |
93 | MP0003950_abnormal_plasma_membrane | 0.81740810 |
94 | MP0002095_abnormal_skin_pigmentation | 0.81656502 |
95 | MP0005384_cellular_phenotype | 0.81179123 |
96 | MP0002234_abnormal_pharynx_morphology | 0.78973623 |
97 | MP0003656_abnormal_erythrocyte_physiolo | 0.77725814 |
98 | MP0002233_abnormal_nose_morphology | 0.76673727 |
99 | MP0003699_abnormal_female_reproductive | 0.76202212 |
100 | MP0003119_abnormal_digestive_system | 0.76072841 |
101 | MP0004197_abnormal_fetal_growth/weight/ | 0.75279058 |
102 | MP0003221_abnormal_cardiomyocyte_apopto | 0.74384537 |
103 | MP0005621_abnormal_cell_physiology | 0.74196415 |
104 | MP0002837_dystrophic_cardiac_calcinosis | 0.73577733 |
105 | MP0000716_abnormal_immune_system | 0.73042421 |
106 | MP0005084_abnormal_gallbladder_morpholo | 0.72831726 |
107 | MP0005499_abnormal_olfactory_system | 0.72701779 |
108 | MP0005394_taste/olfaction_phenotype | 0.72701779 |
109 | MP0001986_abnormal_taste_sensitivity | 0.71769921 |
110 | MP0001919_abnormal_reproductive_system | 0.71587958 |
111 | MP0001286_abnormal_eye_development | 0.70985089 |
112 | MP0005266_abnormal_metabolism | 0.69123591 |
113 | MP0001727_abnormal_embryo_implantation | 0.67820615 |
114 | MP0002751_abnormal_autonomic_nervous | 0.67770576 |
115 | MP0001984_abnormal_olfaction | 0.66719947 |
116 | MP0010030_abnormal_orbit_morphology | 0.66498367 |
117 | MP0001324_abnormal_eye_pigmentation | 0.66051478 |
118 | MP0002111_abnormal_tail_morphology | 0.65638303 |
119 | MP0002420_abnormal_adaptive_immunity | 0.64579696 |
120 | MP0005332_abnormal_amino_acid | 0.63262159 |
121 | MP0005023_abnormal_wound_healing | 0.63168817 |
122 | MP0001819_abnormal_immune_cell | 0.63080957 |
123 | MP0002723_abnormal_immune_serum | 0.62180907 |
124 | MP0002161_abnormal_fertility/fecundity | 0.61198670 |
125 | MP0003698_abnormal_male_reproductive | 0.60929462 |
126 | MP0003448_altered_tumor_morphology | 0.60926097 |
127 | MP0000372_irregular_coat_pigmentation | 0.60359653 |
128 | MP0002452_abnormal_antigen_presenting | 0.60123125 |
129 | MP0002405_respiratory_system_inflammati | 0.59694036 |
130 | MP0008872_abnormal_physiological_respon | 0.59340264 |
131 | MP0000015_abnormal_ear_pigmentation | 0.57989428 |
132 | MP0005410_abnormal_fertilization | 0.57847036 |
133 | MP0001800_abnormal_humoral_immune | 0.57047618 |
134 | MP0001529_abnormal_vocalization | 0.56386312 |
135 | MP0005551_abnormal_eye_electrophysiolog | 0.55743896 |
136 | MP0002148_abnormal_hypersensitivity_rea | 0.54801116 |
137 | MP0001661_extended_life_span | 0.54076994 |
138 | MP0001293_anophthalmia | 0.53995324 |
139 | MP0000427_abnormal_hair_cycle | 0.53891399 |
140 | MP0000750_abnormal_muscle_regeneration | 0.53255751 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Birth length less than 3rd percentile (HP:0003561) | 5.46046667 |
2 | Breast hypoplasia (HP:0003187) | 4.59894096 |
3 | Carpal bone hypoplasia (HP:0001498) | 3.69397598 |
4 | Reticulocytopenia (HP:0001896) | 3.63843346 |
5 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.58020880 |
6 | Abnormal number of erythroid precursors (HP:0012131) | 3.53289644 |
7 | Degeneration of anterior horn cells (HP:0002398) | 3.49154188 |
8 | Abnormality of the anterior horn cell (HP:0006802) | 3.49154188 |
9 | Oral leukoplakia (HP:0002745) | 3.37761973 |
10 | Rough bone trabeculation (HP:0100670) | 3.36794615 |
11 | Chromsome breakage (HP:0040012) | 3.32160314 |
12 | Patellar aplasia (HP:0006443) | 3.26908043 |
13 | Aplastic anemia (HP:0001915) | 3.26124388 |
14 | Cerebral hypomyelination (HP:0006808) | 3.25703360 |
15 | Cerebral edema (HP:0002181) | 3.19085820 |
16 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.08563496 |
17 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.03527103 |
18 | Premature ovarian failure (HP:0008209) | 2.97865787 |
19 | Abnormality of methionine metabolism (HP:0010901) | 2.96315118 |
20 | Agnosia (HP:0010524) | 2.91805100 |
21 | Methylmalonic acidemia (HP:0002912) | 2.89928992 |
22 | Irregular epiphyses (HP:0010582) | 2.88203794 |
23 | Abnormality of the labia minora (HP:0012880) | 2.83362927 |
24 | Abnormality of the preputium (HP:0100587) | 2.80475176 |
25 | Renal Fanconi syndrome (HP:0001994) | 2.79650230 |
26 | Secondary amenorrhea (HP:0000869) | 2.77611603 |
27 | Macrocytic anemia (HP:0001972) | 2.75994065 |
28 | Acute necrotizing encephalopathy (HP:0006965) | 2.68161652 |
29 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.66977166 |
30 | 11 pairs of ribs (HP:0000878) | 2.63236456 |
31 | Increased CSF lactate (HP:0002490) | 2.62049168 |
32 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.61980062 |
33 | Meckel diverticulum (HP:0002245) | 2.61457385 |
34 | Abnormality of chromosome stability (HP:0003220) | 2.58616106 |
35 | Increased serum lactate (HP:0002151) | 2.58120196 |
36 | Abnormal trabecular bone morphology (HP:0100671) | 2.57568522 |
37 | Abnormal spermatogenesis (HP:0008669) | 2.52700397 |
38 | Abnormality of serum amino acid levels (HP:0003112) | 2.52179992 |
39 | Mitochondrial inheritance (HP:0001427) | 2.50121994 |
40 | Abnormality of the ileum (HP:0001549) | 2.50051156 |
41 | Abnormality of glycolysis (HP:0004366) | 2.49424121 |
42 | Increased serum pyruvate (HP:0003542) | 2.49424121 |
43 | Absent thumb (HP:0009777) | 2.48733081 |
44 | Pallor (HP:0000980) | 2.48722859 |
45 | Microretrognathia (HP:0000308) | 2.48039540 |
46 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.47714136 |
47 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.47714136 |
48 | Methylmalonic aciduria (HP:0012120) | 2.47210834 |
49 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.45942234 |
50 | Hepatocellular necrosis (HP:0001404) | 2.45477898 |
51 | Selective tooth agenesis (HP:0001592) | 2.45369310 |
52 | Colon cancer (HP:0003003) | 2.44722819 |
53 | Myelodysplasia (HP:0002863) | 2.43389575 |
54 | 3-Methylglutaconic aciduria (HP:0003535) | 2.43152364 |
55 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.43120955 |
56 | Hyperglycinemia (HP:0002154) | 2.39778232 |
57 | Absent radius (HP:0003974) | 2.37721596 |
58 | Type 2 muscle fiber atrophy (HP:0003554) | 2.36436619 |
59 | Abnormality of alanine metabolism (HP:0010916) | 2.35730542 |
60 | Hyperalaninemia (HP:0003348) | 2.35730542 |
61 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.35730542 |
62 | Leukodystrophy (HP:0002415) | 2.34062427 |
63 | Horseshoe kidney (HP:0000085) | 2.32191086 |
64 | Increased hepatocellular lipid droplets (HP:0006565) | 2.30904634 |
65 | Bone marrow hypocellularity (HP:0005528) | 2.29414283 |
66 | Respiratory failure (HP:0002878) | 2.28860208 |
67 | Impulsivity (HP:0100710) | 2.27798295 |
68 | Premature graying of hair (HP:0002216) | 2.26943459 |
69 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.26353732 |
70 | Glossoptosis (HP:0000162) | 2.25418773 |
71 | Muscle fiber atrophy (HP:0100295) | 2.23862808 |
72 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.21830851 |
73 | Hepatic necrosis (HP:0002605) | 2.21635010 |
74 | Absent forearm bone (HP:0003953) | 2.20594133 |
75 | Aplasia involving forearm bones (HP:0009822) | 2.20594133 |
76 | Cleft eyelid (HP:0000625) | 2.19943730 |
77 | Trismus (HP:0000211) | 2.19198608 |
78 | Abnormality of the duodenum (HP:0002246) | 2.19027454 |
79 | Increased intramyocellular lipid droplets (HP:0012240) | 2.17467169 |
80 | Reduced antithrombin III activity (HP:0001976) | 2.15343477 |
81 | Amaurosis fugax (HP:0100576) | 2.13061877 |
82 | Ependymoma (HP:0002888) | 2.12291635 |
83 | Pancytopenia (HP:0001876) | 2.11604739 |
84 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.11500054 |
85 | Medulloblastoma (HP:0002885) | 2.11053742 |
86 | Small intestinal stenosis (HP:0012848) | 2.09809971 |
87 | Duodenal stenosis (HP:0100867) | 2.09809971 |
88 | CNS hypomyelination (HP:0003429) | 2.08443796 |
89 | Lethargy (HP:0001254) | 2.07171338 |
90 | Supernumerary spleens (HP:0009799) | 2.06744408 |
91 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.06480811 |
92 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.06480811 |
93 | Abnormal protein glycosylation (HP:0012346) | 2.06480811 |
94 | Abnormal glycosylation (HP:0012345) | 2.06480811 |
95 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.06243923 |
96 | Neoplasm of the pancreas (HP:0002894) | 2.04547259 |
97 | Acute encephalopathy (HP:0006846) | 2.04540177 |
98 | Microvesicular hepatic steatosis (HP:0001414) | 2.02241573 |
99 | Multiple enchondromatosis (HP:0005701) | 2.00307461 |
100 | Neoplasm of the adrenal gland (HP:0100631) | 1.98954610 |
101 | Rhabdomyosarcoma (HP:0002859) | 1.98856644 |
102 | Sparse eyelashes (HP:0000653) | 1.98301602 |
103 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.97511053 |
104 | Progressive macrocephaly (HP:0004481) | 1.96879011 |
105 | Respiratory difficulties (HP:0002880) | 1.96250028 |
106 | Cellular immunodeficiency (HP:0005374) | 1.95516930 |
107 | Exertional dyspnea (HP:0002875) | 1.95279367 |
108 | Azoospermia (HP:0000027) | 1.94895240 |
109 | Amniotic constriction ring (HP:0009775) | 1.94637026 |
110 | Abnormality of placental membranes (HP:0011409) | 1.94637026 |
111 | Lipid accumulation in hepatocytes (HP:0006561) | 1.91761389 |
112 | Type I transferrin isoform profile (HP:0003642) | 1.91589543 |
113 | Optic disc pallor (HP:0000543) | 1.90263592 |
114 | Sloping forehead (HP:0000340) | 1.89736444 |
115 | Exercise intolerance (HP:0003546) | 1.88243678 |
116 | Abnormality of the pons (HP:0007361) | 1.88159049 |
117 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.87803800 |
118 | Postnatal microcephaly (HP:0005484) | 1.87608106 |
119 | Lymphoma (HP:0002665) | 1.87358924 |
120 | Sensory axonal neuropathy (HP:0003390) | 1.85211415 |
121 | CNS demyelination (HP:0007305) | 1.84851610 |
122 | Megaloblastic anemia (HP:0001889) | 1.83378777 |
123 | Absent epiphyses (HP:0010577) | 1.83139283 |
124 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.83139283 |
125 | Lactic acidosis (HP:0003128) | 1.82886929 |
126 | Abnormal lung lobation (HP:0002101) | 1.82366677 |
127 | Facial cleft (HP:0002006) | 1.81486942 |
128 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.80689727 |
129 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.80585333 |
130 | Hypoplasia of the fovea (HP:0007750) | 1.80585333 |
131 | Embryonal renal neoplasm (HP:0011794) | 1.80324171 |
132 | Hypoplasia of the pons (HP:0012110) | 1.79901970 |
133 | Abnormality of homocysteine metabolism (HP:0010919) | 1.78730869 |
134 | Homocystinuria (HP:0002156) | 1.78730869 |
135 | Abnormality of the carotid arteries (HP:0005344) | 1.77410369 |
136 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.77280744 |
137 | Abnormality of glycine metabolism (HP:0010895) | 1.77280744 |
138 | Triphalangeal thumb (HP:0001199) | 1.76986684 |
139 | Median cleft lip (HP:0000161) | 1.76819760 |
140 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.75399438 |
141 | Glioma (HP:0009733) | 1.74501249 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BUB1 | 4.87493424 |
2 | WEE1 | 4.37931018 |
3 | EIF2AK1 | 4.02261958 |
4 | VRK2 | 3.14058267 |
5 | CDC7 | 3.13947002 |
6 | TSSK6 | 3.06650439 |
7 | STK16 | 2.82846731 |
8 | SRPK1 | 2.80206489 |
9 | NME2 | 2.59697332 |
10 | TRIM28 | 2.51036578 |
11 | PLK4 | 2.41299291 |
12 | ACVR1B | 2.41296994 |
13 | EIF2AK3 | 2.36736354 |
14 | BRSK2 | 2.05782841 |
15 | TTK | 2.02093080 |
16 | NUAK1 | 1.97720691 |
17 | NEK1 | 1.94961715 |
18 | VRK1 | 1.94755393 |
19 | PLK3 | 1.94259252 |
20 | PLK1 | 1.90788576 |
21 | NEK2 | 1.85185631 |
22 | CCNB1 | 1.74215010 |
23 | TAF1 | 1.64166578 |
24 | PIM2 | 1.52415141 |
25 | MKNK1 | 1.47167261 |
26 | PBK | 1.46716054 |
27 | WNK3 | 1.44549607 |
28 | NME1 | 1.41093778 |
29 | AURKB | 1.37052397 |
30 | EPHA2 | 1.36447909 |
31 | MST4 | 1.33881710 |
32 | BMPR1B | 1.32717487 |
33 | RPS6KB2 | 1.31032027 |
34 | BRAF | 1.25944941 |
35 | ZAK | 1.25848280 |
36 | MKNK2 | 1.25842297 |
37 | RPS6KA4 | 1.21374497 |
38 | PNCK | 1.21035953 |
39 | AURKA | 1.19909166 |
40 | CDK7 | 1.17774798 |
41 | BRSK1 | 1.16126078 |
42 | AKT3 | 1.15500601 |
43 | ATR | 1.14530123 |
44 | TNIK | 1.12940140 |
45 | ARAF | 1.08329871 |
46 | MAP4K2 | 1.08319249 |
47 | EIF2AK2 | 1.07107767 |
48 | DYRK3 | 1.03799784 |
49 | CHEK2 | 1.01650183 |
50 | TLK1 | 1.00089600 |
51 | ERBB3 | 0.99531983 |
52 | BCR | 0.96894229 |
53 | CSNK1G1 | 0.94599328 |
54 | STK38L | 0.91283715 |
55 | BMPR2 | 0.91170704 |
56 | TESK2 | 0.90657988 |
57 | MAP3K12 | 0.87875810 |
58 | PDK4 | 0.87210074 |
59 | PDK3 | 0.87210074 |
60 | MAP3K8 | 0.85879344 |
61 | PIM1 | 0.85590830 |
62 | PDK2 | 0.85395213 |
63 | CSNK1G3 | 0.83582246 |
64 | CHEK1 | 0.82693077 |
65 | CDK8 | 0.82607552 |
66 | PASK | 0.81352318 |
67 | MAP3K3 | 0.80148309 |
68 | TXK | 0.79893566 |
69 | ALK | 0.77214449 |
70 | FRK | 0.76645589 |
71 | STK10 | 0.75634057 |
72 | MAPKAPK3 | 0.74381662 |
73 | OXSR1 | 0.70753853 |
74 | CSNK1G2 | 0.70613813 |
75 | CSNK2A1 | 0.70540637 |
76 | CSNK2A2 | 0.70040426 |
77 | FLT3 | 0.66355095 |
78 | PAK4 | 0.65132102 |
79 | RAF1 | 0.65049714 |
80 | BCKDK | 0.64857052 |
81 | PRKCI | 0.61164851 |
82 | CSNK1A1L | 0.60925612 |
83 | STK24 | 0.58738845 |
84 | IRAK3 | 0.58507754 |
85 | MAP2K3 | 0.58347832 |
86 | MOS | 0.58288788 |
87 | SCYL2 | 0.58140433 |
88 | PAK1 | 0.57633438 |
89 | GRK1 | 0.56622901 |
90 | MAP3K11 | 0.55762613 |
91 | CSNK1E | 0.55670108 |
92 | ATM | 0.55176220 |
93 | STK39 | 0.55145572 |
94 | IRAK4 | 0.53644444 |
95 | ABL2 | 0.52677485 |
96 | TGFBR1 | 0.51803499 |
97 | CDK4 | 0.51258815 |
98 | PLK2 | 0.51226238 |
99 | CLK1 | 0.49333019 |
100 | KDR | 0.48970297 |
101 | CDK2 | 0.48565217 |
102 | ERBB4 | 0.48281030 |
103 | ZAP70 | 0.45812745 |
104 | TAOK2 | 0.43844911 |
105 | MAP3K5 | 0.43618639 |
106 | TEC | 0.43342822 |
107 | FGFR1 | 0.42930923 |
108 | ADRBK2 | 0.42521831 |
109 | DYRK2 | 0.41350809 |
110 | MAP4K1 | 0.40382414 |
111 | STK4 | 0.39699206 |
112 | MAP3K6 | 0.38747105 |
113 | IKBKB | 0.37988684 |
114 | MAP3K4 | 0.37194938 |
115 | * CDK1 | 0.35294489 |
116 | CDK3 | 0.33472257 |
117 | DAPK1 | 0.31739259 |
118 | LATS2 | 0.30897768 |
119 | MAPKAPK5 | 0.30896352 |
120 | MARK3 | 0.30084081 |
121 | RPS6KA5 | 0.29912944 |
122 | MAP2K7 | 0.29821282 |
123 | TESK1 | 0.29636607 |
124 | NEK9 | 0.28098598 |
125 | PRKDC | 0.26756185 |
126 | WNK4 | 0.26029382 |
127 | STK3 | 0.25400093 |
128 | MINK1 | 0.25377475 |
129 | MELK | 0.24952623 |
130 | LIMK1 | 0.23311453 |
131 | CSNK1A1 | 0.21395660 |
132 | CDK9 | 0.20338714 |
133 | PRKCG | 0.19823867 |
134 | INSRR | 0.19478010 |
135 | LYN | 0.19326445 |
136 | YES1 | 0.19161441 |
137 | PRKACB | 0.17884234 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Proteasome_Homo sapiens_hsa03050 | 4.66516120 |
2 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 4.14288836 |
3 | RNA polymerase_Homo sapiens_hsa03020 | 4.12334814 |
4 | DNA replication_Homo sapiens_hsa03030 | 4.08072276 |
5 | Mismatch repair_Homo sapiens_hsa03430 | 3.57891213 |
6 | Ribosome_Homo sapiens_hsa03010 | 3.46192521 |
7 | RNA transport_Homo sapiens_hsa03013 | 3.04938328 |
8 | Spliceosome_Homo sapiens_hsa03040 | 2.98541113 |
9 | Homologous recombination_Homo sapiens_hsa03440 | 2.87373116 |
10 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.64802735 |
11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.62462167 |
12 | Base excision repair_Homo sapiens_hsa03410 | 2.59493700 |
13 | Basal transcription factors_Homo sapiens_hsa03022 | 2.39369671 |
14 | Cell cycle_Homo sapiens_hsa04110 | 2.31798486 |
15 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.25239065 |
16 | RNA degradation_Homo sapiens_hsa03018 | 2.05567555 |
17 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.02770187 |
18 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.91918953 |
19 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.82774429 |
20 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.65277204 |
21 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.62449543 |
22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.61451546 |
23 | Purine metabolism_Homo sapiens_hsa00230 | 1.56119029 |
24 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.46897513 |
25 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.40428764 |
26 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.35258569 |
27 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.34461897 |
28 | Huntingtons disease_Homo sapiens_hsa05016 | 1.24146829 |
29 | Parkinsons disease_Homo sapiens_hsa05012 | 1.23603106 |
30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.20953455 |
31 | Protein export_Homo sapiens_hsa03060 | 1.17600370 |
32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.16205483 |
33 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.09721956 |
34 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.05149185 |
35 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.04139820 |
36 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.03965626 |
37 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.03815682 |
38 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.92597617 |
39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.90254178 |
40 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.85486136 |
41 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.84054009 |
42 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.82233265 |
43 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.77784757 |
44 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.77130436 |
45 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.76853863 |
46 | Legionellosis_Homo sapiens_hsa05134 | 0.76659982 |
47 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.74693409 |
48 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.72689787 |
49 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.71993218 |
50 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.71550241 |
51 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.69706350 |
52 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.67141921 |
53 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.66021313 |
54 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.64405093 |
55 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.61991652 |
56 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.57509662 |
57 | Thyroid cancer_Homo sapiens_hsa05216 | 0.55400276 |
58 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.55227786 |
59 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.54552865 |
60 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.53573401 |
61 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.52772692 |
62 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.51627635 |
63 | Sulfur relay system_Homo sapiens_hsa04122 | 0.50275261 |
64 | Peroxisome_Homo sapiens_hsa04146 | 0.50119700 |
65 | Alzheimers disease_Homo sapiens_hsa05010 | 0.50098599 |
66 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.47226479 |
67 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.46358462 |
68 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.43734441 |
69 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.43682340 |
70 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.43124473 |
71 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.42670745 |
72 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.42511523 |
73 | Carbon metabolism_Homo sapiens_hsa01200 | 0.42493720 |
74 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.42155120 |
75 | Allograft rejection_Homo sapiens_hsa05330 | 0.41486055 |
76 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.40928200 |
77 | Metabolic pathways_Homo sapiens_hsa01100 | 0.39330699 |
78 | HTLV-I infection_Homo sapiens_hsa05166 | 0.38857431 |
79 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.38590743 |
80 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.37476591 |
81 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.37353113 |
82 | Measles_Homo sapiens_hsa05162 | 0.37322659 |
83 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.37076606 |
84 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.36306450 |
85 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.35216908 |
86 | Apoptosis_Homo sapiens_hsa04210 | 0.33990514 |
87 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.33650897 |
88 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.33405097 |
89 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.33268351 |
90 | Shigellosis_Homo sapiens_hsa05131 | 0.32476906 |
91 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.31065174 |
92 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.30004385 |
93 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.29626088 |
94 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.29486620 |
95 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.29395527 |
96 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.28575726 |
97 | Influenza A_Homo sapiens_hsa05164 | 0.28194420 |
98 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.26600446 |
99 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.26568490 |
100 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.22070272 |
101 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.21874256 |
102 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.21733537 |
103 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.19846666 |
104 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.19775941 |
105 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.19437153 |
106 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.17813922 |
107 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.17055685 |
108 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.16648095 |
109 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.16336348 |
110 | Galactose metabolism_Homo sapiens_hsa00052 | 0.16024523 |
111 | Hepatitis B_Homo sapiens_hsa05161 | 0.14855167 |
112 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.14543991 |
113 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.13647046 |
114 | Phototransduction_Homo sapiens_hsa04744 | 0.13267508 |
115 | Phagosome_Homo sapiens_hsa04145 | 0.13052637 |
116 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.13012425 |
117 | Retinol metabolism_Homo sapiens_hsa00830 | 0.12580559 |
118 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.12494182 |
119 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.12096827 |
120 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.11954042 |
121 | Asthma_Homo sapiens_hsa05310 | 0.11953229 |
122 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.11859960 |
123 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.11158516 |
124 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.10910439 |
125 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.10210528 |
126 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.08533534 |
127 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.08347241 |
128 | Circadian rhythm_Homo sapiens_hsa04710 | 0.06600112 |
129 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.06018830 |
130 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.05906877 |
131 | Alcoholism_Homo sapiens_hsa05034 | 0.05219235 |
132 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.04955094 |
133 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.03938754 |
134 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.02400823 |