PAK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.14400327
2axon ensheathment in central nervous system (GO:0032291)8.14400327
3short-term memory (GO:0007614)5.75218009
4presynaptic membrane assembly (GO:0097105)5.21251526
5positive regulation of gamma-delta T cell activation (GO:0046645)4.90603989
6presynaptic membrane organization (GO:0097090)4.85760045
7limb bud formation (GO:0060174)4.67243862
8positive regulation of protein kinase C signaling (GO:0090037)4.61775692
9positive regulation by symbiont of host defense response (GO:0052509)4.58985282
10modulation by symbiont of host defense response (GO:0052031)4.58985282
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58985282
12modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58985282
13positive regulation by organism of defense response of other organism involved in symbiotic interact4.58985282
14modulation by symbiont of host immune response (GO:0052553)4.58985282
15retina layer formation (GO:0010842)4.29559223
16myelination (GO:0042552)4.16514596
17ensheathment of neurons (GO:0007272)4.14694269
18axon ensheathment (GO:0008366)4.14694269
19long-chain fatty acid biosynthetic process (GO:0042759)4.10463334
20neuron cell-cell adhesion (GO:0007158)4.08214771
21fatty acid elongation (GO:0030497)3.99771563
22regulation of histone H3-K27 methylation (GO:0061085)3.93052429
23negative regulation of erythrocyte differentiation (GO:0045647)3.90421874
24neuron remodeling (GO:0016322)3.87979701
25negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.85605740
26regulation of gamma-delta T cell activation (GO:0046643)3.79812712
27hepatocyte apoptotic process (GO:0097284)3.79318993
28detection of molecule of bacterial origin (GO:0032490)3.77806058
29regulation of gamma-delta T cell differentiation (GO:0045586)3.77355492
30oligodendrocyte differentiation (GO:0048709)3.72596534
31cellular extravasation (GO:0045123)3.71977898
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.71605644
33postsynaptic membrane organization (GO:0001941)3.64495890
34response to peptidoglycan (GO:0032494)3.63900203
35photoreceptor cell differentiation (GO:0046530)3.60415154
36eye photoreceptor cell differentiation (GO:0001754)3.60415154
37negative regulation of cell killing (GO:0031342)3.49864808
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49864808
39macrophage activation involved in immune response (GO:0002281)3.41423656
40import into cell (GO:0098657)3.36150897
41metanephric tubule development (GO:0072170)3.34500591
42metanephric nephron tubule development (GO:0072234)3.34500591
43regulation of B cell receptor signaling pathway (GO:0050855)3.32222357
44cerebral cortex radially oriented cell migration (GO:0021799)3.30945040
45organ growth (GO:0035265)3.29303495
46regulation of pigment cell differentiation (GO:0050932)3.28905269
47lateral sprouting from an epithelium (GO:0060601)3.26613220
48negative regulation of neurotransmitter transport (GO:0051589)3.26517779
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22206622
50histone H2B ubiquitination (GO:0033523)3.19656354
51leukocyte aggregation (GO:0070486)3.18111564
52response to host defenses (GO:0052200)3.18093708
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18093708
54response to host (GO:0075136)3.18093708
55negative regulation of neurotransmitter secretion (GO:0046929)3.11546692
56JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.11433234
57metanephric nephron epithelium development (GO:0072243)3.11228615
58positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09516750
59regulation of RNA export from nucleus (GO:0046831)3.05162700
60detection of external biotic stimulus (GO:0098581)3.05047426
61response to host immune response (GO:0052572)3.04618769
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.04618769
63neuronal action potential propagation (GO:0019227)3.02635906
64otic vesicle formation (GO:0030916)3.02544727
65regulation of timing of cell differentiation (GO:0048505)3.00272023
66B cell receptor signaling pathway (GO:0050853)2.99669738
67keratinocyte development (GO:0003334)2.99269025
68neuron recognition (GO:0008038)2.98321982
69detection of other organism (GO:0098543)2.98048096
70hypotonic response (GO:0006971)2.97526242
71histone H3-K36 demethylation (GO:0070544)2.96827014
72cranial nerve morphogenesis (GO:0021602)2.96723053
73negative regulation of T cell mediated immunity (GO:0002710)2.95946594
74response to interleukin-15 (GO:0070672)2.95456005
75antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.95073982
76iron ion import (GO:0097286)2.94316090
77negative regulation of protein localization to cell surface (GO:2000009)2.92371540
78metanephric epithelium development (GO:0072207)2.91513094
79spermatid nucleus differentiation (GO:0007289)2.90446617
80negative regulation of keratinocyte proliferation (GO:0010839)2.90425357
81response to muramyl dipeptide (GO:0032495)2.88410338
82neutrophil activation involved in immune response (GO:0002283)2.88408422
83positive regulation of synapse assembly (GO:0051965)2.86429592
84nuclear pore complex assembly (GO:0051292)2.84691704
85transmission of nerve impulse (GO:0019226)2.83002761
86regulation of collateral sprouting (GO:0048670)2.82097937
87germinal center formation (GO:0002467)2.80603281
88embryonic process involved in female pregnancy (GO:0060136)2.80262572
89antigen processing and presentation of endogenous antigen (GO:0019883)2.79983947
90negative thymic T cell selection (GO:0045060)2.79718053
91eyelid development in camera-type eye (GO:0061029)2.78709012
92regulation of nucleobase-containing compound transport (GO:0032239)2.78290728
93antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.78179003
94L-amino acid import (GO:0043092)2.77807430
95positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76940470
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.76324374
97regulation of protein kinase A signaling (GO:0010738)2.76278395
98protein localization to endosome (GO:0036010)2.75624090
99COPI coating of Golgi vesicle (GO:0048205)2.74974919
100Golgi transport vesicle coating (GO:0048200)2.74974919
1013-UTR-mediated mRNA stabilization (GO:0070935)2.74248344
102cytoplasmic mRNA processing body assembly (GO:0033962)2.74147982
103righting reflex (GO:0060013)2.72872655
104thymic T cell selection (GO:0045061)2.72615335
105regulation of somitogenesis (GO:0014807)2.72450237
106regulation of interferon-beta biosynthetic process (GO:0045357)2.71789019
107nephron epithelium development (GO:0072009)2.71363400
108T cell selection (GO:0045058)2.70883948
109negative T cell selection (GO:0043383)2.70512267
110negative regulation of interleukin-12 production (GO:0032695)2.68373505
111cellular response to epinephrine stimulus (GO:0071872)2.67571015
112endothelium development (GO:0003158)2.67523745
113microglial cell activation (GO:0001774)2.66231460
114cilium movement (GO:0003341)2.65260468
115* regulation of defense response to virus by virus (GO:0050690)2.64810793
116regulation of leukocyte degranulation (GO:0043300)2.64344967
117detection of bacterium (GO:0016045)2.63802777
118positive regulation of oligodendrocyte differentiation (GO:0048714)2.63664898
119regulation of feeding behavior (GO:0060259)2.63045555
120membrane assembly (GO:0071709)2.63021717
121mesenchymal cell differentiation involved in renal system development (GO:2001012)2.61951796
122mesenchymal cell differentiation involved in kidney development (GO:0072161)2.61951796
123negative regulation of lymphocyte mediated immunity (GO:0002707)2.61903891
124positive regulation of Cdc42 GTPase activity (GO:0043089)2.60165045
125phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.59807003
126negative regulation of myoblast differentiation (GO:0045662)2.59064104
127regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59026814
128positive regulation of B cell differentiation (GO:0045579)2.57673283
129regulation of development, heterochronic (GO:0040034)2.57223907
130spinal cord motor neuron differentiation (GO:0021522)2.57098880
131response to laminar fluid shear stress (GO:0034616)2.56985365
132detection of biotic stimulus (GO:0009595)2.56932693
133positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.56111917
134branch elongation of an epithelium (GO:0060602)2.55504475
135negative regulation of synaptic transmission, GABAergic (GO:0032229)2.52770510
136ionotropic glutamate receptor signaling pathway (GO:0035235)2.52326082
137cranial nerve development (GO:0021545)2.52236726
138amino acid import (GO:0043090)2.52079845
139dendritic spine morphogenesis (GO:0060997)2.51957001
140macrophage activation (GO:0042116)2.51906220
141glutamate receptor signaling pathway (GO:0007215)2.51701868
142lipopolysaccharide-mediated signaling pathway (GO:0031663)2.51460812
143interferon-gamma secretion (GO:0072643)2.51304886
144negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.51158473
145positive regulation of action potential (GO:0045760)2.50968858
146neutrophil activation (GO:0042119)2.50508663
147positive regulation of meiosis (GO:0045836)2.50211363
148protein palmitoylation (GO:0018345)2.49737032
149positive regulation of keratinocyte differentiation (GO:0045618)2.49245051
150developmental pigmentation (GO:0048066)2.47526155
151positive regulation of meiotic cell cycle (GO:0051446)2.47343952
152positive regulation of neurological system process (GO:0031646)2.46757764
153antigen processing and presentation via MHC class Ib (GO:0002475)2.46667323
154megakaryocyte development (GO:0035855)2.44781248
155forebrain neuron differentiation (GO:0021879)2.42578240
156neutrophil mediated immunity (GO:0002446)2.42376470
157regulation of protein kinase C signaling (GO:0090036)2.42111247
158regulation of mast cell degranulation (GO:0043304)2.41616409
159collecting duct development (GO:0072044)2.40698437
160cellular response to interleukin-15 (GO:0071350)2.40560710
161granulocyte activation (GO:0036230)2.40088721
162melanin metabolic process (GO:0006582)2.39941381
163activated T cell proliferation (GO:0050798)2.39639625
164response to epinephrine (GO:0071871)2.39147182
165positive thymic T cell selection (GO:0045059)2.38880310
166axonemal dynein complex assembly (GO:0070286)2.38673732
167asymmetric protein localization (GO:0008105)2.37124693
168cell proliferation in forebrain (GO:0021846)2.36995881
169myelin maintenance (GO:0043217)2.36575127
170glial cell differentiation (GO:0010001)2.36038137
171glycerophospholipid catabolic process (GO:0046475)2.35993303
172protein localization to synapse (GO:0035418)2.35121967
173epithelial cell differentiation involved in prostate gland development (GO:0060742)2.34411421
174negative regulation of axon extension (GO:0030517)2.34187372
175GMP metabolic process (GO:0046037)2.33213626
176head development (GO:0060322)2.32919908
177melanin biosynthetic process (GO:0042438)2.32725790
178Leydig cell differentiation (GO:0033327)2.32675524
179enteric nervous system development (GO:0048484)2.32656326
180polyol transport (GO:0015791)2.32525063
181startle response (GO:0001964)2.31155401
182positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.31143438
183astrocyte development (GO:0014002)2.30825804
184regulation of B cell differentiation (GO:0045577)2.30591963
185T cell migration (GO:0072678)2.29330749
186positive T cell selection (GO:0043368)2.29032872
187regulation of regulated secretory pathway (GO:1903305)2.27957376
188histone lysine demethylation (GO:0070076)2.27599688
189negative regulation of leukocyte mediated immunity (GO:0002704)2.27147646
190corticosteroid receptor signaling pathway (GO:0031958)2.26081772
191insulin-like growth factor receptor signaling pathway (GO:0048009)2.24490237
192regulation of myeloid leukocyte mediated immunity (GO:0002886)2.24072628
193positive regulation of protein import into nucleus, translocation (GO:0033160)2.23446729
194myeloid cell activation involved in immune response (GO:0002275)2.22717741
195mRNA stabilization (GO:0048255)2.21308289
196RNA stabilization (GO:0043489)2.21308289
197negative regulation of fibroblast apoptotic process (GO:2000270)2.20962083
198negative regulation of toll-like receptor signaling pathway (GO:0034122)2.20560004
199positive regulation of regulated secretory pathway (GO:1903307)2.20287159
200glucocorticoid receptor signaling pathway (GO:0042921)2.20028077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.31192664
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.30085397
3EZH2_22144423_ChIP-Seq_EOC_Human4.11215090
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.61382153
5MYC_22102868_ChIP-Seq_BL_Human3.38476157
6GBX2_23144817_ChIP-Seq_PC3_Human3.05884158
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.92907561
8ESR1_20079471_ChIP-ChIP_T-47D_Human2.84278952
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84252262
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.80733074
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.80299497
12TAF15_26573619_Chip-Seq_HEK293_Human2.69877657
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68594784
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62812557
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.55813655
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.55024019
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.54798545
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48544518
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.48371815
20VDR_21846776_ChIP-Seq_THP-1_Human2.46619527
21AR_21572438_ChIP-Seq_LNCaP_Human2.46572792
22TCF7_22412390_ChIP-Seq_EML_Mouse2.45330687
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45048209
24VDR_22108803_ChIP-Seq_LS180_Human2.42354861
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40748045
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.38563856
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32245079
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28833811
29BMI1_23680149_ChIP-Seq_NPCS_Mouse2.26917669
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25673421
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25600942
32RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25600942
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23669373
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22649711
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14783863
36IRF8_27001747_Chip-Seq_BMDM_Mouse2.13294321
37VDR_24763502_ChIP-Seq_THP-1_Human2.12047425
38TP63_17297297_ChIP-ChIP_HaCaT_Human2.11848518
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11674837
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10704454
41JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06894383
42MAF_26560356_Chip-Seq_TH1_Human2.05866911
43BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05502202
44SCL_19346495_ChIP-Seq_HPC-7_Human2.02297039
45IRF8_21731497_ChIP-ChIP_J774_Mouse2.01474206
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.99627838
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99381783
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98968178
49RUNX_20019798_ChIP-Seq_JUKART_Human1.96165770
50SPI1_23127762_ChIP-Seq_K562_Human1.94067185
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92176980
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90338379
53MYB_26560356_Chip-Seq_TH2_Human1.88707340
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.88398084
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.88312359
56KDM2B_26808549_Chip-Seq_DND41_Human1.86982459
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85791549
58* SPI1_23547873_ChIP-Seq_NB4_Human1.83079382
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82295037
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.82190734
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80708832
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.79960298
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79405767
64MYB_26560356_Chip-Seq_TH1_Human1.79138082
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78932658
66FUS_26573619_Chip-Seq_HEK293_Human1.78463600
67MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78211638
68ELK3_25401928_ChIP-Seq_HUVEC_Human1.77703093
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77679120
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.77280653
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76862959
72RNF2_27304074_Chip-Seq_NSC_Mouse1.76322055
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76229587
74TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74385026
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.73804101
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73588747
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73402746
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.72094679
79TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71812488
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.69633773
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.68563575
82P300_19829295_ChIP-Seq_ESCs_Human1.67142539
83* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66447346
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66207212
85UTX_26944678_Chip-Seq_JUKART_Human1.65899748
86FOXM1_23109430_ChIP-Seq_U2OS_Human1.62964904
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62573331
88* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61944238
89E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61083479
90* ER_23166858_ChIP-Seq_MCF-7_Human1.57551963
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.57207138
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53932368
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.53219297
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52125296
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51707908
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.50974037
97WT1_19549856_ChIP-ChIP_CCG9911_Human1.50680070
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.47162746
99BP1_19119308_ChIP-ChIP_Hs578T_Human1.46726781
100* KDM2B_26808549_Chip-Seq_JURKAT_Human1.46328109
101RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.45860730
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45430356
103GATA1_22025678_ChIP-Seq_K562_Human1.44270869
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42931331
105* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38182314
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36351719
107IGF1R_20145208_ChIP-Seq_DFB_Human1.36289574
108NFE2_27457419_Chip-Seq_LIVER_Mouse1.36248972
109IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36243490
110KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36134509
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36030474
112SMAD4_21799915_ChIP-Seq_A2780_Human1.35333317
113RACK7_27058665_Chip-Seq_MCF-7_Human1.35008862
114PU_27001747_Chip-Seq_BMDM_Mouse1.34165331
115CLOCK_20551151_ChIP-Seq_293T_Human1.33450477
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.33201784
117UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32906401
118* MAF_26560356_Chip-Seq_TH2_Human1.32617497
119STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31869507
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.30033063
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.29280098
122GATA1_19941827_ChIP-Seq_MEL_Mouse1.29245451
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28869039
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.27940752
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27437789
126* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27429975
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.27340023
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27211080
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.25859348
130TP53_18474530_ChIP-ChIP_U2OS_Human1.25836840
131P53_22387025_ChIP-Seq_ESCs_Mouse1.25446247
132VDR_24787735_ChIP-Seq_THP-1_Human1.24747979
133P300_18555785_Chip-Seq_ESCs_Mouse1.24569602
134HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24494168
135GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23248056
136P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21415061
137TP53_16413492_ChIP-PET_HCT116_Human1.20560056
138TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19041693
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19041693
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18778709
141RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18534712
142IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17986632
143GATA2_21666600_ChIP-Seq_HMVEC_Human1.17501566
144TRIM28_21343339_ChIP-Seq_HEK293_Human1.17021793
145TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.16762183
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16456935
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16456935
148RUNX1_27514584_Chip-Seq_MCF-7_Human1.16201514
149KDM2B_26808549_Chip-Seq_K562_Human1.15146764
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15083986
151GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13827004
152RING1B_27294783_Chip-Seq_NPCs_Mouse1.12976450
153RUNX2_22187159_ChIP-Seq_PCA_Human1.11659936
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11058942
155NCOR1_26117541_ChIP-Seq_K562_Human1.10973604
156TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10130271
157ESR1_21235772_ChIP-Seq_MCF-7_Human1.09990312
158RUNX1_27457419_Chip-Seq_LIVER_Mouse1.09616384
159RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09607218
160E2F7_22180533_ChIP-Seq_HELA_Human1.09602952
161STAT3_18555785_Chip-Seq_ESCs_Mouse1.09543213
162SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09231545
163TAL1_26923725_Chip-Seq_HPCs_Mouse1.08901818
164NMYC_18555785_Chip-Seq_ESCs_Mouse1.08394067
165AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08349190
166PRDM14_20953172_ChIP-Seq_ESCs_Human1.07954679
167SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07858846
168FOXO3_23340844_ChIP-Seq_DLD1_Human1.07625062
169NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07468429
170WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07386107
171SOX2_18555785_Chip-Seq_ESCs_Mouse1.07241665
172TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06205580
173TFEB_21752829_ChIP-Seq_HELA_Human1.06201863
174GATA1_19941826_ChIP-Seq_K562_Human1.06162083
175STAT3_23295773_ChIP-Seq_U87_Human1.05206243
176IRF1_19129219_ChIP-ChIP_H3396_Human1.05115005
177SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04839366
178OCT4_18555785_Chip-Seq_ESCs_Mouse1.04406207
179RING1B_27294783_Chip-Seq_ESCs_Mouse1.04071928
180KDM2B_26808549_Chip-Seq_REH_Human1.04049466
181EWS_26573619_Chip-Seq_HEK293_Human1.03350719
182* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02962232
183NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02040394
184KLF4_18555785_Chip-Seq_ESCs_Mouse1.01558356
185CHD1_26751641_Chip-Seq_LNCaP_Human1.00872018
186FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.00254748
187MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99904364
188CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99870139
189TCF4_23295773_ChIP-Seq_U87_Human0.99405280
190GATA3_27048872_Chip-Seq_THYMUS_Human0.98881822
191TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97918993
192GATA2_19941826_ChIP-Seq_K562_Human0.96888566
193PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95046056
194* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92092751
195* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91672559
196FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90783894
197SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90217570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.63729984
2MP0005409_darkened_coat_color4.95894776
3MP0001188_hyperpigmentation4.20970345
4MP0004381_abnormal_hair_follicle4.13694970
5MP0003880_abnormal_central_pattern3.84631030
6MP0002877_abnormal_melanocyte_morpholog3.00774250
7MP0003300_gastrointestinal_ulcer2.98350208
8MP0004742_abnormal_vestibular_system2.85895866
9MP0009379_abnormal_foot_pigmentation2.66744654
10MP0002102_abnormal_ear_morphology2.66204438
11MP0002009_preneoplasia2.51984125
12MP0003705_abnormal_hypodermis_morpholog2.51597453
13MP0003436_decreased_susceptibility_to2.50793700
14MP0000920_abnormal_myelination2.46452936
15MP0002396_abnormal_hematopoietic_system2.37175657
16MP0003191_abnormal_cellular_cholesterol2.34492171
17MP0001835_abnormal_antigen_presentation2.33527689
18MP0004264_abnormal_extraembryonic_tissu2.31989892
19MP0003183_abnormal_peptide_metabolism2.30531096
20MP0003763_abnormal_thymus_physiology2.28556297
21MP0005423_abnormal_somatic_nervous2.13319818
22MP0002166_altered_tumor_susceptibility2.12845164
23MP0006292_abnormal_olfactory_placode2.06283420
24MP0005076_abnormal_cell_differentiation1.95979694
25MP0001486_abnormal_startle_reflex1.94827214
26MP0004947_skin_inflammation1.92327496
27MP0003950_abnormal_plasma_membrane1.91482779
28MP0003938_abnormal_ear_development1.91467932
29MP0000778_abnormal_nervous_system1.86432295
30MP0010234_abnormal_vibrissa_follicle1.86416032
31MP0002419_abnormal_innate_immunity1.85814191
32MP0005171_absent_coat_pigmentation1.83955108
33MP0001800_abnormal_humoral_immune1.80384710
34MP0003566_abnormal_cell_adhesion1.75586168
35MP0005000_abnormal_immune_tolerance1.71853684
36MP0002272_abnormal_nervous_system1.70285149
37MP0003091_abnormal_cell_migration1.69443731
38MP0002006_tumorigenesis1.67700349
39MP0000685_abnormal_immune_system1.67452778
40MP0000566_synostosis1.64508146
41MP0005174_abnormal_tail_pigmentation1.63344186
42MP0004185_abnormal_adipocyte_glucose1.62171104
43MP0001968_abnormal_touch/_nociception1.61835244
44MP0004808_abnormal_hematopoietic_stem1.61309661
45MP0005025_abnormal_response_to1.60863899
46MP0000015_abnormal_ear_pigmentation1.60574100
47MP0002452_abnormal_antigen_presenting1.60398587
48MP0002420_abnormal_adaptive_immunity1.59839787
49MP0003828_pulmonary_edema1.59439519
50MP0000383_abnormal_hair_follicle1.58722009
51MP0001819_abnormal_immune_cell1.58268805
52MP0004270_analgesia1.57318537
53MP0002398_abnormal_bone_marrow1.57138524
54MP0002723_abnormal_immune_serum1.57038665
55MP0003172_abnormal_lysosome_physiology1.50852990
56MP0008057_abnormal_DNA_replication1.50687817
57MP0005387_immune_system_phenotype1.50431031
58MP0001790_abnormal_immune_system1.50431031
59MP0004142_abnormal_muscle_tone1.49021869
60MP0004233_abnormal_muscle_weight1.48987579
61MP0005464_abnormal_platelet_physiology1.48870343
62MP0000858_altered_metastatic_potential1.48542287
63MP0003937_abnormal_limbs/digits/tail_de1.47357112
64MP0010352_gastrointestinal_tract_polyps1.45982170
65MP0008260_abnormal_autophagy1.45835189
66MP0001873_stomach_inflammation1.45654248
67MP0009745_abnormal_behavioral_response1.44616590
68MP0002249_abnormal_larynx_morphology1.44470886
69MP0005671_abnormal_response_to1.41534391
70MP0005551_abnormal_eye_electrophysiolog1.41290628
71MP0000703_abnormal_thymus_morphology1.40352155
72MP0003724_increased_susceptibility_to1.38475355
73MP0009250_abnormal_appendicular_skeleto1.37717768
74MP0002064_seizures1.37386484
75MP0001905_abnormal_dopamine_level1.37113879
76MP0000569_abnormal_digit_pigmentation1.36018712
77MP0000716_abnormal_immune_system1.35744537
78MP0002796_impaired_skin_barrier1.34581301
79MP0002405_respiratory_system_inflammati1.34253332
80MP0009278_abnormal_bone_marrow1.33631029
81MP0003221_abnormal_cardiomyocyte_apopto1.33222250
82MP0006072_abnormal_retinal_apoptosis1.32656613
83MP0000026_abnormal_inner_ear1.29303707
84MP0002067_abnormal_sensory_capabilities1.28698249
85MP0010155_abnormal_intestine_physiology1.28335173
86MP0002277_abnormal_respiratory_mucosa1.28135664
87MP0009046_muscle_twitch1.27679504
88MP0002177_abnormal_outer_ear1.26066099
89MP0001440_abnormal_grooming_behavior1.25843487
90MP0002722_abnormal_immune_system1.25744242
91MP0003635_abnormal_synaptic_transmissio1.25443856
92MP0005058_abnormal_lysosome_morphology1.25387150
93MP0004883_abnormal_blood_vessel1.24308486
94MP0001529_abnormal_vocalization1.22972177
95MP0001485_abnormal_pinna_reflex1.22704675
96MP0001533_abnormal_skeleton_physiology1.21841729
97MP0002752_abnormal_somatic_nervous1.19771653
98MP0009785_altered_susceptibility_to1.18674462
99MP0003315_abnormal_perineum_morphology1.18570191
100MP0010678_abnormal_skin_adnexa1.17354189
101MP0005248_abnormal_Harderian_gland1.17240784
102MP0000462_abnormal_digestive_system1.17051643
103MP0009333_abnormal_splenocyte_physiolog1.15745344
104MP0003453_abnormal_keratinocyte_physiol1.15165998
105MP0002734_abnormal_mechanical_nocicepti1.14780339
106MP0002429_abnormal_blood_cell1.13478998
107MP0000689_abnormal_spleen_morphology1.13419990
108MP0000762_abnormal_tongue_morphology1.13364136
109MP0006276_abnormal_autonomic_nervous1.12224093
110MP0000631_abnormal_neuroendocrine_gland1.12030318
111MP0000049_abnormal_middle_ear1.11083113
112MP0002572_abnormal_emotion/affect_behav1.09480314
113MP0000627_abnormal_mammary_gland1.08355750
114MP0001963_abnormal_hearing_physiology1.08133121
115MP0003656_abnormal_erythrocyte_physiolo1.06304637
116MP0002148_abnormal_hypersensitivity_rea1.06008703
117MP0005310_abnormal_salivary_gland1.05409097
118MP0001970_abnormal_pain_threshold1.05313364
119MP0003448_altered_tumor_morphology1.03259137
120MP0006082_CNS_inflammation1.02379675
121MP0005623_abnormal_meninges_morphology1.01797548
122MP0000467_abnormal_esophagus_morphology1.01440688
123MP0003634_abnormal_glial_cell1.01139670
124MP0002882_abnormal_neuron_morphology1.00856203
125MP0005666_abnormal_adipose_tissue1.00711084
126MP0005379_endocrine/exocrine_gland_phen0.99997061
127MP0009384_cardiac_valve_regurgitation0.99807360
128MP0003690_abnormal_glial_cell0.99620832
129MP0001340_abnormal_eyelid_morphology0.99450913
130MP0004885_abnormal_endolymph0.98593116
131MP0005195_abnormal_posterior_eye0.98356765
132MP0002998_abnormal_bone_remodeling0.96852356
133MP0005164_abnormal_response_to0.96348001
134MP0001501_abnormal_sleep_pattern0.96092596
135MP0002098_abnormal_vibrissa_morphology0.95815071
136MP0000647_abnormal_sebaceous_gland0.95197948
137MP0001845_abnormal_inflammatory_respons0.94964627
138MP0000465_gastrointestinal_hemorrhage0.93113041
139MP0003866_abnormal_defecation0.92851230
140MP0005083_abnormal_biliary_tract0.92805168
141MP0001661_extended_life_span0.91921575
142MP0003385_abnormal_body_wall0.91514441
143MP0000579_abnormal_nail_morphology0.91351323
144MP0009115_abnormal_fat_cell0.91141768
145MP0002557_abnormal_social/conspecific_i0.90597346
146MP0002086_abnormal_extraembryonic_tissu0.90191034
147MP0001216_abnormal_epidermal_layer0.89947327
148MP0002184_abnormal_innervation0.89901979
149MP0005621_abnormal_cell_physiology0.89271612
150MP0001849_ear_inflammation0.88767389
151MP0001346_abnormal_lacrimal_gland0.88647085
152MP0003941_abnormal_skin_development0.88577052
153MP0003303_peritoneal_inflammation0.87167662
154MP0005451_abnormal_body_composition0.86417327
155MP0002938_white_spotting0.86350004
156MP0000767_abnormal_smooth_muscle0.85032338
157MP0002229_neurodegeneration0.84934663
158MP0001986_abnormal_taste_sensitivity0.83654721
159MP0003755_abnormal_palate_morphology0.83510263
160MP0001881_abnormal_mammary_gland0.83251951
161MP0002282_abnormal_trachea_morphology0.81709878
162MP0005397_hematopoietic_system_phenotyp0.78524947
163MP0001545_abnormal_hematopoietic_system0.78524947
164MP0002063_abnormal_learning/memory/cond0.78090772
165MP0005501_abnormal_skin_physiology0.77303139
166MP0004145_abnormal_muscle_electrophysio0.76964362
167MP0002751_abnormal_autonomic_nervous0.75382547
168MP0001851_eye_inflammation0.75256542
169MP0002735_abnormal_chemical_nociception0.75010901
170MP0002152_abnormal_brain_morphology0.74086211
171MP0000955_abnormal_spinal_cord0.73764050
172MP0000613_abnormal_salivary_gland0.73237527
173MP0001853_heart_inflammation0.73222578
174MP0005253_abnormal_eye_physiology0.73105139
175MP0001915_intracranial_hemorrhage0.72411947
176MP0001299_abnormal_eye_distance/0.71170603
177MP0002066_abnormal_motor_capabilities/c0.71128541
178MP0001286_abnormal_eye_development0.71084601
179MP0000427_abnormal_hair_cycle0.70936343
180MP0005375_adipose_tissue_phenotype0.70717439
181MP0001730_embryonic_growth_arrest0.70381916
182MP0002019_abnormal_tumor_incidence0.70376228
183MP0005595_abnormal_vascular_smooth0.70273740
184MP0000371_diluted_coat_color0.70107766
185MP0002733_abnormal_thermal_nociception0.69867343
186MP0001348_abnormal_lacrimal_gland0.69662938
187MP0002233_abnormal_nose_morphology0.67830680
188MP0008995_early_reproductive_senescence0.67696843
189MP0003011_delayed_dark_adaptation0.67460386
190MP0005645_abnormal_hypothalamus_physiol0.65714859
191MP0000432_abnormal_head_morphology0.65371263
192MP0002736_abnormal_nociception_after0.64338562

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.25627436
2Abnormality of secondary sexual hair (HP:0009888)4.22494914
3Abnormality of the axillary hair (HP:0100134)4.22494914
4Parakeratosis (HP:0001036)4.21637343
5Abnormal ciliary motility (HP:0012262)4.09708467
6Absent/shortened dynein arms (HP:0200106)3.72754591
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.72754591
8Abnormal respiratory motile cilium physiology (HP:0012261)3.65489974
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.55605840
10Eczematoid dermatitis (HP:0000976)3.52214998
11Sex reversal (HP:0012245)3.46450421
12Abnormal sex determination (HP:0012244)3.46450421
13Degeneration of the lateral corticospinal tracts (HP:0002314)3.38519331
14Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.38519331
15Peripheral hypomyelination (HP:0007182)3.29389654
16Septo-optic dysplasia (HP:0100842)3.27614390
17Obstructive sleep apnea (HP:0002870)3.19595836
18Asymmetry of the thorax (HP:0001555)3.14958676
19Alacrima (HP:0000522)3.14612599
20Neurofibrillary tangles (HP:0002185)3.12247692
21Abnormal respiratory motile cilium morphology (HP:0005938)3.06727500
22Abnormal respiratory epithelium morphology (HP:0012253)3.06727500
23Recurrent abscess formation (HP:0002722)3.02284198
24Absent septum pellucidum (HP:0001331)2.97647530
25Chin dimple (HP:0010751)2.97141928
26Sensory axonal neuropathy (HP:0003390)2.95548937
27Recurrent bacterial skin infections (HP:0005406)2.93322326
28T lymphocytopenia (HP:0005403)2.86504429
29Concave nail (HP:0001598)2.80346048
30Flat acetabular roof (HP:0003180)2.80113777
31Abnormality of the septum pellucidum (HP:0007375)2.79923663
32Absent speech (HP:0001344)2.73150559
33Orchitis (HP:0100796)2.70428606
34Abnormality of macrophages (HP:0004311)2.67372481
35Attenuation of retinal blood vessels (HP:0007843)2.66939328
36Myositis (HP:0100614)2.66366055
37Decreased lacrimation (HP:0000633)2.64373515
38Subacute progressive viral hepatitis (HP:0006572)2.59890021
39White forelock (HP:0002211)2.58721221
40Cellulitis (HP:0100658)2.54736693
41Hyperacusis (HP:0010780)2.54577773
42Cupped ear (HP:0000378)2.52680135
43Optic neuritis (HP:0100653)2.48254572
44Retrobulbar optic neuritis (HP:0100654)2.48254572
45Papillary thyroid carcinoma (HP:0002895)2.47715568
46Overfolded helix (HP:0000396)2.43679407
47Patchy hypopigmentation of hair (HP:0011365)2.42645176
48Recurrent fungal infections (HP:0002841)2.41332955
49Aplasia cutis congenita (HP:0001057)2.41216442
50Recurrent viral infections (HP:0004429)2.41131888
51Abnormality of T cell number (HP:0011839)2.40194668
52Gastrointestinal infarctions (HP:0005244)2.39399368
53Rhinitis (HP:0012384)2.35747709
54Optic nerve hypoplasia (HP:0000609)2.35270636
55Deep philtrum (HP:0002002)2.34280257
56Broad-based gait (HP:0002136)2.34231550
57Spontaneous hematomas (HP:0007420)2.33382193
58Atelectasis (HP:0100750)2.32923412
59Termporal pattern (HP:0011008)2.32820712
60Insidious onset (HP:0003587)2.32820712
61Meningitis (HP:0001287)2.29453059
62Focal motor seizures (HP:0011153)2.28985534
63Ankyloglossia (HP:0010296)2.23558760
64Viral hepatitis (HP:0006562)2.20617027
65Abnormally folded helix (HP:0008544)2.19530673
66Hypoplasia of the iris (HP:0007676)2.18318631
67Arterial thrombosis (HP:0004420)2.17202613
68Curly hair (HP:0002212)2.16617806
69Onion bulb formation (HP:0003383)2.16455001
70Spinal cord lesions (HP:0100561)2.16034576
71Syringomyelia (HP:0003396)2.16034576
72Gingivitis (HP:0000230)2.15227900
73Macroorchidism (HP:0000053)2.14707935
74Sparse lateral eyebrow (HP:0005338)2.13584974
75Slow saccadic eye movements (HP:0000514)2.13375217
76Cerebral inclusion bodies (HP:0100314)2.12391729
77Congenital ichthyosiform erythroderma (HP:0007431)2.11907962
78Retinal dysplasia (HP:0007973)2.10223264
79Heterotopia (HP:0002282)2.08447597
80Conical tooth (HP:0000698)2.07314999
81Esotropia (HP:0000565)2.06943328
82Optic disc pallor (HP:0000543)2.06887378
83Chest pain (HP:0100749)2.06519694
84Abnormality of the corticospinal tract (HP:0002492)2.06230171
85Split foot (HP:0001839)2.05406622
86Thickened helices (HP:0000391)2.05231315
87Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.05057970
88Sleep apnea (HP:0010535)2.04051528
89Humeroradial synostosis (HP:0003041)2.03715128
90Synostosis involving the elbow (HP:0003938)2.03715128
91Peritonitis (HP:0002586)2.03199780
92Broad face (HP:0000283)2.01969959
93Hypoplastic pelvis (HP:0008839)2.00799816
94Abnormality of liposaccharide metabolism (HP:0010968)2.00754796
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.00754796
96Abnormality of glycolipid metabolism (HP:0010969)2.00754796
97Nasolacrimal duct obstruction (HP:0000579)2.00380610
98Abnormality of the fingertips (HP:0001211)2.00313118
99Abnormality of oral frenula (HP:0000190)1.99871887
100Short tibia (HP:0005736)1.97210519
101Micronodular cirrhosis (HP:0001413)1.96272389
102Partial duplication of thumb phalanx (HP:0009944)1.95899988
103Nephronophthisis (HP:0000090)1.95810779
104Asplenia (HP:0001746)1.95708923
105Absent frontal sinuses (HP:0002688)1.94927677
106Congenital sensorineural hearing impairment (HP:0008527)1.94860071
107Arterial tortuosity (HP:0005116)1.93817931
108Anomalous pulmonary venous return (HP:0010772)1.93816095
109Coarse hair (HP:0002208)1.93742990
110Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93559954
111Mixed hearing impairment (HP:0000410)1.93518993
112Abnormality of the pulmonary veins (HP:0011718)1.92961022
113Seborrheic dermatitis (HP:0001051)1.92399836
114Recurrent skin infections (HP:0001581)1.92266434
115Intellectual disability, moderate (HP:0002342)1.92156101
116Gingival bleeding (HP:0000225)1.91976528
117Increased IgE level (HP:0003212)1.91635339
118Recurrent cutaneous fungal infections (HP:0011370)1.89020728
119Chronic mucocutaneous candidiasis (HP:0002728)1.89020728
120Mediastinal lymphadenopathy (HP:0100721)1.88825758
121Decreased central vision (HP:0007663)1.88484759
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.88469105
123Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87706465
124Esophageal atresia (HP:0002032)1.86946967
125Keratoconjunctivitis sicca (HP:0001097)1.85673337
126Submucous cleft hard palate (HP:0000176)1.85009730
127Gastrointestinal inflammation (HP:0004386)1.84923091
128Abnormality of the thoracic spine (HP:0100711)1.84751944
129Recurrent gram-negative bacterial infections (HP:0005420)1.83923745
130Abnormality of the distal phalanx of the thumb (HP:0009617)1.83557375
131Thoracic kyphosis (HP:0002942)1.82923184
132Clumsiness (HP:0002312)1.82102472
133Upper limb muscle weakness (HP:0003484)1.81855941
134Dysostosis multiplex (HP:0000943)1.81838608
135Aplasia involving bones of the extremities (HP:0009825)1.80989480
136Aplasia involving bones of the upper limbs (HP:0009823)1.80989480
137Aplasia of the phalanges of the hand (HP:0009802)1.80989480
138Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80769187
139Abnormality of the lumbar spine (HP:0100712)1.80444337
140Vasculitis (HP:0002633)1.78130055
141Partial duplication of the phalanx of hand (HP:0009999)1.78066790
142Thickened calvaria (HP:0002684)1.78058983
143Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78026828
144Hypophosphatemic rickets (HP:0004912)1.77958296
145Aplasia/Hypoplasia of the spleen (HP:0010451)1.77949195
146Thyroid-stimulating hormone excess (HP:0002925)1.77595306
147Bowel incontinence (HP:0002607)1.77555101
148Supernumerary spleens (HP:0009799)1.76833522
149Adrenal hypoplasia (HP:0000835)1.76292617
150Granulocytopenia (HP:0001913)1.75908805
151Renal agenesis (HP:0000104)1.75343793
152Morphological abnormality of the inner ear (HP:0011390)1.75017202
153Inflammation of the large intestine (HP:0002037)1.74556555
154Osteolytic defects of the hand bones (HP:0009699)1.74439742
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.74439742
156Abnormal delayed hypersensitivity skin test (HP:0002963)1.74070183
157Abnormal auditory evoked potentials (HP:0006958)1.73968738
158Metaphyseal cupping (HP:0003021)1.73772402
159Osteomyelitis (HP:0002754)1.73350600
160Obstructive lung disease (HP:0006536)1.73335637
161Chronic obstructive pulmonary disease (HP:0006510)1.73335637
162Duplication of thumb phalanx (HP:0009942)1.72219290
163Abnormal large intestine physiology (HP:0012700)1.72119112
164Abnormality of the renal medulla (HP:0100957)1.71937658
165Duplicated collecting system (HP:0000081)1.71781128
166Encephalitis (HP:0002383)1.71447221
167Abnormality of the endocardium (HP:0004306)1.71155215
168Dysmetria (HP:0001310)1.70940072
169Abnormality of the peritoneum (HP:0002585)1.70668174
170Hemiparesis (HP:0001269)1.69694224
171Partial agenesis of the corpus callosum (HP:0001338)1.69546670
172Aplasia/hypoplasia of the uterus (HP:0008684)1.68847687
173Acute myeloid leukemia (HP:0004808)1.68781487
174Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68456509
175Polygenic inheritance (HP:0010982)1.68417068
176Congenital malformation of the right heart (HP:0011723)1.68178271
177Double outlet right ventricle (HP:0001719)1.68178271
178Myelomeningocele (HP:0002475)1.67792353
179Amaurosis fugax (HP:0100576)1.67102140
180Long nose (HP:0003189)1.66758241
181Ulnar claw (HP:0001178)1.66753248
182Missing ribs (HP:0000921)1.65102267
183Widely spaced teeth (HP:0000687)1.64993315
184Aneurysm (HP:0002617)1.63183751
185Interstitial pulmonary disease (HP:0006530)1.63094571
186Periodontitis (HP:0000704)1.62910340
187Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62398335
188Vascular tortuosity (HP:0004948)1.62048592
189Epistaxis (HP:0000421)1.61591453
190Patellar dislocation (HP:0002999)1.61240399
191Abnormal platelet volume (HP:0011876)1.60822269
192Fatigue (HP:0012378)1.60743046
193Germ cell neoplasia (HP:0100728)1.60072104
194Panhypogammaglobulinemia (HP:0003139)1.60010395
195Transitional cell carcinoma of the bladder (HP:0006740)1.58388562
196Craniofacial hyperostosis (HP:0004493)1.57797919
197Prolonged bleeding time (HP:0003010)1.57660669
198Renal cell carcinoma (HP:0005584)1.57304394
199Dilatation of the ascending aorta (HP:0005111)1.56486356

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.36695203
2TRIB33.77963795
3STK393.33399684
4MKNK23.10674341
5PRPF4B2.83469160
6CDK122.82478164
7PNCK2.76882823
8BLK2.49363558
9SMG12.44502774
10ERN12.39015785
11ICK2.34421205
12PKN12.30716311
13TNIK2.28643413
14MAP3K142.27517469
15OXSR12.17415780
16PHKG22.06760283
17PHKG12.06760283
18TLK12.01383450
19MAPK151.94664454
20SCYL21.93142565
21PKN21.91526623
22FES1.89361641
23MKNK11.86771582
24MAP3K131.84386657
25FGFR41.80118283
26MAP2K31.71597151
27FGR1.70751329
28GRK11.69784341
29EPHB11.69689543
30SIK31.69052149
31MAP4K11.67613330
32KSR21.66927912
33CLK11.51548700
34ZAP701.49579776
35NEK91.46282693
36TYK21.44431319
37IRAK11.44317229
38SIK11.44079839
39MST41.43684168
40MAP3K101.34141525
41JAK31.32796566
42KSR11.32713412
43BTK1.32413338
44FGFR31.32287206
45LRRK21.30371387
46MAPKAPK51.29426918
47RIPK11.26669349
48PBK1.26019322
49MUSK1.22809614
50TAF11.22419968
51JAK11.21966400
52IRAK21.19010748
53PTK61.19000588
54CAMK2B1.17700439
55NEK61.15890007
56JAK21.15308794
57RPS6KB21.13794980
58BCR1.11929799
59MAP3K21.10846848
60RET1.10342426
61EEF2K1.09976030
62ROCK21.09641249
63DYRK21.09453840
64WNK41.09209971
65EPHA41.08929966
66CAMK1D1.06414214
67BMPR1B1.06401152
68CDK61.05697634
69HCK1.05191591
70GRK71.04868624
71NTRK31.03244638
72MAP3K61.03234035
73PDGFRA1.03084763
74MAP3K31.02639659
75BRD41.01246158
76UHMK11.00494648
77YES11.00328245
78CSNK1G10.98981238
79SGK30.96179785
80CSNK1A1L0.96015831
81CAMK1G0.95214721
82PDGFRB0.94063129
83CSF1R0.92695985
84CDK30.92235097
85TTN0.92039109
86STK160.91975950
87NTRK20.90768165
88MTOR0.90649780
89WNK10.89488210
90GRK60.87619669
91NLK0.85079146
92DMPK0.84867680
93CSNK1G30.83659463
94STK100.83612717
95CAMK2D0.82487467
96SYK0.82457458
97CAMK2A0.81972832
98MAPK130.81711501
99IRAK40.81222170
100MAP3K90.80558632
101ADRBK20.79349758
102DYRK1A0.77693631
103MARK20.76844656
104PRKCE0.76057045
105FER0.75542031
106MELK0.75335632
107CDK40.74025721
108SRPK10.72404878
109CAMKK10.70193264
110PDK10.69316921
111FGFR20.67641099
112PDPK10.66484923
113TAOK10.66321660
114PRKCQ0.66307636
115MARK10.66203641
116IKBKE0.65908645
117CSK0.65408571
118CSNK1G20.64430251
119NUAK10.63031363
120MET0.62650844
121INSRR0.61089992
122RAF10.60884413
123RPS6KA50.60666242
124PRKD20.59174206
125CDK190.58483453
126ITK0.58195332
127MAP3K80.57700539
128GSK3A0.56850597
129PAK40.56381599
130SGK20.55156900
131BMPR20.55110783
132CDC42BPA0.55022067
133RIPK40.54685547
134STK110.53204837
135NME10.52741849
136MAPKAPK20.51935071
137EPHA20.51533564
138CAMK2G0.51402886
139MAP2K20.50932407
140ERBB40.50583143
141CDK70.49851953
142LATS10.49750454
143EIF2AK10.48920038
144MOS0.48768825
145HIPK20.48501656
146* PRKG10.48159970
147NEK20.47710934
148TXK0.47542785
149MARK30.47414553
150PRKD10.47312805
151PIK3CA0.47199114
152CAMKK20.47076330
153TGFBR20.46898271
154TRPM70.46407221
155EIF2AK20.46203752
156CSNK1D0.45883015
157CDK90.45832002
158LCK0.45709284
159VRK10.45703905
160LATS20.44614304
161CDK50.44526891
162TAOK20.44314229
163FYN0.42453053
164NTRK10.42362713
165IRAK30.40454962
166SIK20.38664857
167EPHB20.36946415
168MAPK100.36011216
169PAK10.33837020
170PRKACA0.33680978
171PAK30.32845179
172INSR0.30682219
173EPHA30.30036207
174MAP3K10.29779743
175PAK60.28951880
176TAOK30.28837790
177ROCK10.27485677

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.84022390
2Ether lipid metabolism_Homo sapiens_hsa005652.51598065
3Nicotine addiction_Homo sapiens_hsa050332.46804792
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42435126
5Chronic myeloid leukemia_Homo sapiens_hsa052202.35287588
6Acute myeloid leukemia_Homo sapiens_hsa052212.31755938
7B cell receptor signaling pathway_Homo sapiens_hsa046622.27550281
8Sphingolipid metabolism_Homo sapiens_hsa006002.16727271
9Cell adhesion molecules (CAMs)_Homo sapiens_hsa045142.15075146
10Non-small cell lung cancer_Homo sapiens_hsa052232.13965205
11Pancreatic cancer_Homo sapiens_hsa052122.04469493
12Fatty acid elongation_Homo sapiens_hsa000621.96239171
13* Axon guidance_Homo sapiens_hsa043601.92387275
14Osteoclast differentiation_Homo sapiens_hsa043801.89524560
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85343105
16Serotonergic synapse_Homo sapiens_hsa047261.84117600
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.80164809
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.79063980
19Long-term depression_Homo sapiens_hsa047301.77656044
20Endometrial cancer_Homo sapiens_hsa052131.75259125
21Glutamatergic synapse_Homo sapiens_hsa047241.74260943
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73249036
23Protein export_Homo sapiens_hsa030601.72298664
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71323141
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68979025
26* T cell receptor signaling pathway_Homo sapiens_hsa046601.68474391
27Leishmaniasis_Homo sapiens_hsa051401.68320225
28Thyroid cancer_Homo sapiens_hsa052161.68194116
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63713451
30Oxidative phosphorylation_Homo sapiens_hsa001901.62231985
31Measles_Homo sapiens_hsa051621.58037362
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56894770
33Hepatitis B_Homo sapiens_hsa051611.55191022
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.54380481
35Steroid biosynthesis_Homo sapiens_hsa001001.54070697
36Prolactin signaling pathway_Homo sapiens_hsa049171.53633481
37Autoimmune thyroid disease_Homo sapiens_hsa053201.47878462
38VEGF signaling pathway_Homo sapiens_hsa043701.47322027
39Taste transduction_Homo sapiens_hsa047421.46490295
40Morphine addiction_Homo sapiens_hsa050321.46401989
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42517792
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.39818800
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37958630
44Notch signaling pathway_Homo sapiens_hsa043301.34600048
45GABAergic synapse_Homo sapiens_hsa047271.32591772
46Colorectal cancer_Homo sapiens_hsa052101.32153133
47Hepatitis C_Homo sapiens_hsa051601.31580894
48Tuberculosis_Homo sapiens_hsa051521.26600451
49Linoleic acid metabolism_Homo sapiens_hsa005911.25757882
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25419585
51* ErbB signaling pathway_Homo sapiens_hsa040121.25028360
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.24918942
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24817564
54Toxoplasmosis_Homo sapiens_hsa051451.24687195
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22877518
56TNF signaling pathway_Homo sapiens_hsa046681.22348694
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20451848
58Influenza A_Homo sapiens_hsa051641.20315925
59Alzheimers disease_Homo sapiens_hsa050101.20302193
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.18933537
61mTOR signaling pathway_Homo sapiens_hsa041501.18251328
62Salivary secretion_Homo sapiens_hsa049701.17568718
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17207390
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17092075
65Shigellosis_Homo sapiens_hsa051311.14564072
66Cocaine addiction_Homo sapiens_hsa050301.13066759
67Glioma_Homo sapiens_hsa052141.12707286
68Platelet activation_Homo sapiens_hsa046111.12571946
69Bladder cancer_Homo sapiens_hsa052191.09083778
70Small cell lung cancer_Homo sapiens_hsa052221.08820895
71Renin secretion_Homo sapiens_hsa049241.08602348
72NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08357661
73Arachidonic acid metabolism_Homo sapiens_hsa005901.08170245
74Primary immunodeficiency_Homo sapiens_hsa053401.05444683
75Calcium signaling pathway_Homo sapiens_hsa040201.04807813
76Fanconi anemia pathway_Homo sapiens_hsa034601.04491188
77Central carbon metabolism in cancer_Homo sapiens_hsa052301.03713686
78Melanogenesis_Homo sapiens_hsa049161.03294668
79FoxO signaling pathway_Homo sapiens_hsa040681.03092514
80Hedgehog signaling pathway_Homo sapiens_hsa043401.02775671
81Dorso-ventral axis formation_Homo sapiens_hsa043201.01993875
82Asthma_Homo sapiens_hsa053100.99848477
83Wnt signaling pathway_Homo sapiens_hsa043100.99779221
84Apoptosis_Homo sapiens_hsa042100.98807071
85Legionellosis_Homo sapiens_hsa051340.98646003
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97221350
87Proteoglycans in cancer_Homo sapiens_hsa052050.96685181
88Amoebiasis_Homo sapiens_hsa051460.96293129
89Cardiac muscle contraction_Homo sapiens_hsa042600.95753370
90Adherens junction_Homo sapiens_hsa045200.94834420
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.93996840
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93893111
93Herpes simplex infection_Homo sapiens_hsa051680.93207598
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92055456
95Viral carcinogenesis_Homo sapiens_hsa052030.91745865
96Inositol phosphate metabolism_Homo sapiens_hsa005620.90402511
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86957659
98Insulin signaling pathway_Homo sapiens_hsa049100.86735525
99Estrogen signaling pathway_Homo sapiens_hsa049150.86692081
100Circadian entrainment_Homo sapiens_hsa047130.86232751
101* Ras signaling pathway_Homo sapiens_hsa040140.86199347
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.85680272
103Salmonella infection_Homo sapiens_hsa051320.84699331
104Parkinsons disease_Homo sapiens_hsa050120.83498224
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83034005
106Endocytosis_Homo sapiens_hsa041440.82933415
107Viral myocarditis_Homo sapiens_hsa054160.82737573
108Amphetamine addiction_Homo sapiens_hsa050310.82723254
109Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82605428
110Basal cell carcinoma_Homo sapiens_hsa052170.82583579
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82425144
112* Focal adhesion_Homo sapiens_hsa045100.80849614
113Insulin resistance_Homo sapiens_hsa049310.80774500
114ECM-receptor interaction_Homo sapiens_hsa045120.79833989
115HIF-1 signaling pathway_Homo sapiens_hsa040660.79781948
116Malaria_Homo sapiens_hsa051440.79528408
117Gastric acid secretion_Homo sapiens_hsa049710.78762181
118Rheumatoid arthritis_Homo sapiens_hsa053230.78686453
119Choline metabolism in cancer_Homo sapiens_hsa052310.78417685
120HTLV-I infection_Homo sapiens_hsa051660.78346949
121Huntingtons disease_Homo sapiens_hsa050160.77712139
122Phospholipase D signaling pathway_Homo sapiens_hsa040720.77617930
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77577791
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76316264
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75189391
126Dopaminergic synapse_Homo sapiens_hsa047280.74367703
127Pancreatic secretion_Homo sapiens_hsa049720.74107648
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73269983
129cAMP signaling pathway_Homo sapiens_hsa040240.72812155
130Oxytocin signaling pathway_Homo sapiens_hsa049210.72477528
131Staphylococcus aureus infection_Homo sapiens_hsa051500.72435004
132Cholinergic synapse_Homo sapiens_hsa047250.71556088
133Ribosome_Homo sapiens_hsa030100.71247540
134Tight junction_Homo sapiens_hsa045300.70161813
135Graft-versus-host disease_Homo sapiens_hsa053320.69762291
136Ovarian steroidogenesis_Homo sapiens_hsa049130.69028513
137GnRH signaling pathway_Homo sapiens_hsa049120.68901425
138Gap junction_Homo sapiens_hsa045400.68076689
139Antigen processing and presentation_Homo sapiens_hsa046120.67991971
140Epstein-Barr virus infection_Homo sapiens_hsa051690.65698949
141Allograft rejection_Homo sapiens_hsa053300.65277336
142Phagosome_Homo sapiens_hsa041450.65102874
143Long-term potentiation_Homo sapiens_hsa047200.62892732
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.62575731
145Lysosome_Homo sapiens_hsa041420.62495041
146African trypanosomiasis_Homo sapiens_hsa051430.61640586
147Histidine metabolism_Homo sapiens_hsa003400.61233690
148Hematopoietic cell lineage_Homo sapiens_hsa046400.60559059
149* MAPK signaling pathway_Homo sapiens_hsa040100.60210747
150Other glycan degradation_Homo sapiens_hsa005110.58439035
151* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57678060
152Melanoma_Homo sapiens_hsa052180.57104031
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56666870
154Mineral absorption_Homo sapiens_hsa049780.56538310
155AMPK signaling pathway_Homo sapiens_hsa041520.55832129
156Prion diseases_Homo sapiens_hsa050200.54945698
157* Renal cell carcinoma_Homo sapiens_hsa052110.54773301
158Basal transcription factors_Homo sapiens_hsa030220.54527994
159Prostate cancer_Homo sapiens_hsa052150.53686469
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52655031
161Rap1 signaling pathway_Homo sapiens_hsa040150.52630218
162MicroRNAs in cancer_Homo sapiens_hsa052060.51239385
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50865174
164Dilated cardiomyopathy_Homo sapiens_hsa054140.50250929
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49604697
166Glycosaminoglycan degradation_Homo sapiens_hsa005310.48660583
167Type II diabetes mellitus_Homo sapiens_hsa049300.47146833
168Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47085857
169Collecting duct acid secretion_Homo sapiens_hsa049660.46556610
170Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46479450
171Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45785872
172Leukocyte transendothelial migration_Homo sapiens_hsa046700.45487372
173Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45429186
174cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45331223
175Pathways in cancer_Homo sapiens_hsa052000.42645853
176Chemokine signaling pathway_Homo sapiens_hsa040620.42493930
177Vibrio cholerae infection_Homo sapiens_hsa051100.41864434
178TGF-beta signaling pathway_Homo sapiens_hsa043500.41486432
179Non-homologous end-joining_Homo sapiens_hsa034500.40528744

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