PAK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)5.34878844
2polyketide metabolic process (GO:0030638)4.71296396
3doxorubicin metabolic process (GO:0044598)4.71296396
4daunorubicin metabolic process (GO:0044597)4.71296396
5paraxial mesoderm development (GO:0048339)4.69014894
6regulation of gene silencing by RNA (GO:0060966)4.54737086
7regulation of posttranscriptional gene silencing (GO:0060147)4.54737086
8regulation of gene silencing by miRNA (GO:0060964)4.54737086
9sulfur amino acid catabolic process (GO:0000098)4.02374007
10planar cell polarity pathway involved in neural tube closure (GO:0090179)3.99324051
11protein localization to kinetochore (GO:0034501)3.88667723
12proline biosynthetic process (GO:0006561)3.73312700
13regulation of hippo signaling (GO:0035330)3.67498656
14mitotic metaphase plate congression (GO:0007080)3.65108079
15mitotic sister chromatid segregation (GO:0000070)3.58065627
16regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.54001028
17epithelial cell-cell adhesion (GO:0090136)3.53450570
18negative regulation of cell size (GO:0045792)3.53264360
19determination of adult lifespan (GO:0008340)3.50491853
20intestinal epithelial cell development (GO:0060576)3.46699091
21mitotic nuclear envelope disassembly (GO:0007077)3.46399426
22regulation of fatty acid beta-oxidation (GO:0031998)3.46063637
23heterochromatin organization (GO:0070828)3.43000736
24establishment of apical/basal cell polarity (GO:0035089)3.42988958
25DNA replication-dependent nucleosome assembly (GO:0006335)3.42631543
26DNA replication-dependent nucleosome organization (GO:0034723)3.42631543
27semaphorin-plexin signaling pathway (GO:0071526)3.38003551
28positive regulation of histone deacetylation (GO:0031065)3.37847410
29pre-miRNA processing (GO:0031054)3.37050909
30folic acid-containing compound biosynthetic process (GO:0009396)3.34569461
31nuclear pore organization (GO:0006999)3.34562647
32convergent extension (GO:0060026)3.34488696
33protein localization to chromosome, centromeric region (GO:0071459)3.33667166
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33127699
35positive regulation of fatty acid beta-oxidation (GO:0032000)3.29113147
36GDP-mannose metabolic process (GO:0019673)3.25927600
37cell-cell junction maintenance (GO:0045217)3.22079860
38activation of Rac GTPase activity (GO:0032863)3.22009310
39notochord development (GO:0030903)3.17626303
40membrane disassembly (GO:0030397)3.17530561
41nuclear envelope disassembly (GO:0051081)3.17530561
42regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.17295508
43positive regulation of SMAD protein import into nucleus (GO:0060391)3.17230946
44aminoglycoside antibiotic metabolic process (GO:0030647)3.17108502
45sister chromatid segregation (GO:0000819)3.17074344
46regulation of glucose import in response to insulin stimulus (GO:2001273)3.13645410
47DNA unwinding involved in DNA replication (GO:0006268)3.13579923
48regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09336224
49histone H4-K12 acetylation (GO:0043983)3.07770262
50nuclear pore complex assembly (GO:0051292)3.05980926
51branching involved in salivary gland morphogenesis (GO:0060445)3.04834035
52DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.04198490
53metaphase plate congression (GO:0051310)3.03591055
54regulation of translational fidelity (GO:0006450)2.99727532
55negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.98953265
56regulation of sister chromatid cohesion (GO:0007063)2.98503054
57regulation of telomere maintenance via telomerase (GO:0032210)2.98081473
58apoptotic process involved in morphogenesis (GO:0060561)2.97320792
59negative regulation of meiosis (GO:0045835)2.96014677
60DNA replication initiation (GO:0006270)2.95864350
61intracellular estrogen receptor signaling pathway (GO:0030520)2.95461140
62trophectodermal cell differentiation (GO:0001829)2.94603572
63DNA damage response, signal transduction resulting in transcription (GO:0042772)2.93432259
64DNA replication checkpoint (GO:0000076)2.91897196
65positive regulation of triglyceride biosynthetic process (GO:0010867)2.90264620
66mammary gland epithelial cell differentiation (GO:0060644)2.89453916
67atrioventricular valve morphogenesis (GO:0003181)2.89260999
68branching involved in mammary gland duct morphogenesis (GO:0060444)2.87875800
69proline metabolic process (GO:0006560)2.87410919
70formation of translation preinitiation complex (GO:0001731)2.85576110
71Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.84634021
72dosage compensation (GO:0007549)2.83546217
73regulation of SMAD protein import into nucleus (GO:0060390)2.82814966
74peptidyl-arginine omega-N-methylation (GO:0035247)2.81614016
75endothelial cell chemotaxis (GO:0035767)2.81291035
76protein insertion into membrane (GO:0051205)2.81098447
77regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.80553913
78regulation of spindle organization (GO:0090224)2.80464603
79bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79841079
80columnar/cuboidal epithelial cell development (GO:0002066)2.79687203
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.79343981
82response to food (GO:0032094)2.78585831
83nodal signaling pathway (GO:0038092)2.77128517
84negative regulation of histone methylation (GO:0031061)2.76960438
85regulation of gene silencing (GO:0060968)2.76598307
86biotin metabolic process (GO:0006768)2.76003192
87regulation of cholesterol biosynthetic process (GO:0045540)2.75365473
88UTP biosynthetic process (GO:0006228)2.75331667
89L-serine metabolic process (GO:0006563)2.74662084
90regulation of stem cell maintenance (GO:2000036)2.74231554
91somatic hypermutation of immunoglobulin genes (GO:0016446)2.74013622
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.74013622
93mitotic chromosome condensation (GO:0007076)2.73797146
94maternal placenta development (GO:0001893)2.73330681
95histone H2A monoubiquitination (GO:0035518)2.73221586
96glucose catabolic process (GO:0006007)2.72754040
97diaphragm development (GO:0060539)2.72713960
98establishment or maintenance of monopolar cell polarity (GO:0061339)2.72642067
99establishment of monopolar cell polarity (GO:0061162)2.72642067
100negative regulation of chromosome segregation (GO:0051985)2.69646523
101positive regulation of chromosome segregation (GO:0051984)2.69319198
102ear development (GO:0043583)2.68908149
103establishment of chromosome localization (GO:0051303)2.66178427
104ribosome assembly (GO:0042255)2.66075510
105regulation of chromosome segregation (GO:0051983)2.64459024
106regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62609197
107embryonic camera-type eye development (GO:0031076)2.62290590
108regulation of establishment of planar polarity (GO:0090175)2.62032616
109nucleoside transmembrane transport (GO:1901642)2.61333804
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61328716
111protein complex localization (GO:0031503)2.61099537
112protein localization to chromosome (GO:0034502)2.60774111
113lung epithelium development (GO:0060428)2.59876082
114DNA strand elongation involved in DNA replication (GO:0006271)2.59703181
115signal transduction involved in regulation of gene expression (GO:0023019)2.59220546
116collecting duct development (GO:0072044)2.58784274
117regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.58699913
118epithelial cell fate commitment (GO:0072148)2.57605168
119Golgi transport vesicle coating (GO:0048200)2.57174287
120COPI coating of Golgi vesicle (GO:0048205)2.57174287
121chromatin assembly (GO:0031497)2.56879265
122polarized epithelial cell differentiation (GO:0030859)2.56600251
123protein retention in ER lumen (GO:0006621)2.55631684
124regulation of centrosome cycle (GO:0046605)2.55105013
125post-embryonic morphogenesis (GO:0009886)2.54571509
126cell junction maintenance (GO:0034331)2.52928644
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.52339820
128negative regulation of sister chromatid segregation (GO:0033046)2.52339820
129negative regulation of mitotic sister chromatid separation (GO:2000816)2.52339820
130negative regulation of mitotic sister chromatid segregation (GO:0033048)2.52339820
131negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.51550558
132establishment or maintenance of apical/basal cell polarity (GO:0035088)2.51078480
133establishment or maintenance of bipolar cell polarity (GO:0061245)2.51078480
134nuclear envelope organization (GO:0006998)2.50179534
135DNA strand elongation (GO:0022616)2.49713410
136regulation of cell proliferation involved in kidney development (GO:1901722)2.49230723
137mitotic spindle assembly checkpoint (GO:0007094)2.48290743
138regulation of water loss via skin (GO:0033561)2.47867326
139kinetochore assembly (GO:0051382)2.47461881
140DNA duplex unwinding (GO:0032508)2.47021120
141DNA geometric change (GO:0032392)2.46929805
142positive regulation of DNA-dependent DNA replication (GO:2000105)2.46927357
143ribosomal small subunit biogenesis (GO:0042274)2.46722913
144spindle checkpoint (GO:0031577)2.46358070
145establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.46043798
146spindle assembly checkpoint (GO:0071173)2.45920948
147pore complex assembly (GO:0046931)2.45896105
148anterior/posterior axis specification, embryo (GO:0008595)2.45813653
149epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.45732654
150basement membrane organization (GO:0071711)2.45143204
151positive regulation of fatty acid oxidation (GO:0046321)2.44961957
152hemidesmosome assembly (GO:0031581)2.44599535
153prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.44281510
154negative regulation of glial cell proliferation (GO:0060253)2.44156714
155negative regulation of gene silencing (GO:0060969)2.43677561
156adherens junction assembly (GO:0034333)2.43201794
157adenine nucleotide transport (GO:0051503)2.42523967
158lung secretory cell differentiation (GO:0061140)2.42155813
159regulation of mitotic spindle organization (GO:0060236)2.41267507
160regulation of helicase activity (GO:0051095)2.40415491
161negative regulation of cell fate specification (GO:0009996)2.39991785
162regulation of double-strand break repair via homologous recombination (GO:0010569)2.39376637
163insulin-like growth factor receptor signaling pathway (GO:0048009)2.39137955
164gap junction assembly (GO:0016264)2.38881327
165histone arginine methylation (GO:0034969)2.38738340
166mitotic spindle checkpoint (GO:0071174)2.38589018
167gene silencing by RNA (GO:0031047)2.36974897
168nuclear envelope reassembly (GO:0031468)2.36611263
169mitotic nuclear envelope reassembly (GO:0007084)2.36611263
170negative regulation of cell fate commitment (GO:0010454)2.36582539
171UTP metabolic process (GO:0046051)2.36517929
172purine nucleotide transport (GO:0015865)2.35906258
173non-canonical Wnt signaling pathway (GO:0035567)2.35509525
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.35480083
175pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.33892038
176white fat cell differentiation (GO:0050872)2.33650257
177skeletal muscle organ development (GO:0060538)2.33636675
178cardiac right ventricle morphogenesis (GO:0003215)2.32914857
179GTP biosynthetic process (GO:0006183)2.32315086
180purine ribonucleotide transport (GO:0015868)2.31748674
181negative regulation of viral release from host cell (GO:1902187)2.31566773
182cochlea morphogenesis (GO:0090103)2.30964722
183protein-DNA complex disassembly (GO:0032986)2.30014097
184nucleosome disassembly (GO:0006337)2.30014097
185cell migration involved in gastrulation (GO:0042074)2.29291566
186morphogenesis of embryonic epithelium (GO:0016331)2.29137902
187apoptotic process involved in development (GO:1902742)2.28017120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.04521289
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.76251727
3ZNF263_19887448_ChIP-Seq_K562_Human3.28309232
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24908187
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.16021549
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.14764462
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.02126252
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.02126252
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.02126252
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69091702
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.60135451
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51411374
13LXR_22292898_ChIP-Seq_THP-1_Human2.49925945
14* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.46419407
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.33570244
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27511026
17NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26802477
18NANOG_18555785_ChIP-Seq_MESCs_Mouse2.24401617
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.23636730
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.21993529
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.13536281
22ESR1_21235772_ChIP-Seq_MCF-7_Human2.10726426
23* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.07956378
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.07022798
25* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.05966400
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.04636654
27ESR1_15608294_ChIP-ChIP_MCF-7_Human2.03924294
28MYC_22102868_ChIP-Seq_BL_Human2.02421530
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.02325202
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01968935
31AR_21909140_ChIP-Seq_LNCAP_Human2.01220929
32* P68_20966046_ChIP-Seq_HELA_Human1.98872394
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.96740593
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.96538826
35MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94233929
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91603737
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91561636
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.90753454
39* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.90203704
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.90079212
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.84985059
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77891289
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.74401884
44* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74366098
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.71702161
46* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.71695390
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.69188804
48* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68577304
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66866146
50HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66680770
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65338172
52XRN2_22483619_ChIP-Seq_HELA_Human1.64697280
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.63347578
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60709070
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60607806
56CREB1_26743006_Chip-Seq_LNCaP_Human1.56923310
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55423002
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54871830
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53501264
60CTCF_27219007_Chip-Seq_Bcells_Human1.51598680
61* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.50652682
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50536767
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49690771
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49437459
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47849113
66* RUNX1_27514584_Chip-Seq_MCF-7_Human1.47261126
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.44885098
68* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44720362
69* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44207839
70SMC4_20622854_ChIP-Seq_HELA_Human1.44182376
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.43091961
72* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42668685
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41913976
74KDM2B_26808549_Chip-Seq_K562_Human1.41376851
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36937373
76* NANOG_21062744_ChIP-ChIP_HESCs_Human1.36160628
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35639958
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35482391
79KDM5A_27292631_Chip-Seq_BREAST_Human1.32994304
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32967810
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.32106367
82* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.31993427
83POU5F1_16518401_ChIP-PET_MESCs_Mouse1.31522111
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30996654
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30936341
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.30082438
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29008455
88TP53_22127205_ChIP-Seq_IMR90_Human1.28977746
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26827861
90PHF8_20622854_ChIP-Seq_HELA_Human1.26483047
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26379718
92SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25739356
93SOX2_18692474_ChIP-Seq_MESCs_Mouse1.25319378
94SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24913124
95* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24248058
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.24094352
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24094235
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23183135
99GABP_19822575_ChIP-Seq_HepG2_Human1.21590642
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.20153577
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.19762100
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19691173
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17979813
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.17814365
105TTF2_22483619_ChIP-Seq_HELA_Human1.17663649
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17572727
107FOXP1_21924763_ChIP-Seq_HESCs_Human1.17270284
108KDM2B_26808549_Chip-Seq_DND41_Human1.15508674
109YY1_21170310_ChIP-Seq_MESCs_Mouse1.15434587
110* ELF1_20517297_ChIP-Seq_JURKAT_Human1.14111241
111TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13623653
112* KAP1_27257070_Chip-Seq_ESCs_Mouse1.13530536
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13328354
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12286401
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12064721
116ATF3_27146783_Chip-Seq_COLON_Human1.11823127
117TCF7_22412390_ChIP-Seq_EML_Mouse1.10936001
118* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.10366374
119EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.10288351
120OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10139656
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10074297
122* E2F1_20622854_ChIP-Seq_HELA_Human1.09935256
123POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09232204
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08655359
125TP63_22573176_ChIP-Seq_HFKS_Human1.08604828
126* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08437931
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06462594
128SALL1_21062744_ChIP-ChIP_HESCs_Human1.06121123
129CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05679845
130CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05624887
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05378913
132GATA6_25053715_ChIP-Seq_YYC3_Human1.05311993
133VDR_21846776_ChIP-Seq_THP-1_Human1.04689290
134CIITA_25753668_ChIP-Seq_RAJI_Human1.04141969
135BCOR_27268052_Chip-Seq_Bcells_Human1.02790046
136ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02647936
137ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02163575
138KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01166568
139DCP1A_22483619_ChIP-Seq_HELA_Human1.01111427
140PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00596062
141SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99983629
142BCL6_27268052_Chip-Seq_Bcells_Human0.99938187
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99823164
144ESR1_20079471_ChIP-ChIP_T-47D_Human0.98915728
145THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98796940
146* CTCF_20526341_ChIP-Seq_ESCs_Human0.98386473
147HIF1A_21447827_ChIP-Seq_MCF-7_Human0.98145285
148NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.98089412
149CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97334417
150WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96430662
151KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95090837
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94557206
153* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93676169
154* RACK7_27058665_Chip-Seq_MCF-7_Human0.93378359
155ELK3_25401928_ChIP-Seq_HUVEC_Human0.92261101
156TFEB_21752829_ChIP-Seq_HELA_Human0.90382433
157GABP_17652178_ChIP-ChIP_JURKAT_Human0.88895643
158NANOG_16153702_ChIP-ChIP_HESCs_Human0.88400878
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87884945
160CHD1_26751641_Chip-Seq_LNCaP_Human0.87466810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.45649397
2MP0010030_abnormal_orbit_morphology3.39964546
3MP0003111_abnormal_nucleus_morphology3.08269220
4MP0004957_abnormal_blastocyst_morpholog3.01739058
5MP0002653_abnormal_ependyma_morphology2.90497395
6MP0004858_abnormal_nervous_system2.77776245
7MP0003077_abnormal_cell_cycle2.54029978
8MP0003878_abnormal_ear_physiology2.50290102
9MP0005377_hearing/vestibular/ear_phenot2.50290102
10MP0000566_synostosis2.47667609
11MP0010094_abnormal_chromosome_stability2.43481883
12MP0008057_abnormal_DNA_replication2.27718315
13MP0010352_gastrointestinal_tract_polyps2.19234019
14MP0004264_abnormal_extraembryonic_tissu2.13467856
15MP0005076_abnormal_cell_differentiation2.04012222
16MP0000678_abnormal_parathyroid_gland2.03859871
17MP0003705_abnormal_hypodermis_morpholog1.94077010
18MP0003283_abnormal_digestive_organ1.92939117
19MP0003119_abnormal_digestive_system1.92879471
20MP0003941_abnormal_skin_development1.90657672
21MP0000537_abnormal_urethra_morphology1.90606921
22MP0001730_embryonic_growth_arrest1.88189060
23MP0005083_abnormal_biliary_tract1.88132173
24* MP0002085_abnormal_embryonic_tissue1.82477397
25MP0003890_abnormal_embryonic-extraembry1.78609875
26MP0002084_abnormal_developmental_patter1.78401561
27MP0005670_abnormal_white_adipose1.73173592
28* MP0000350_abnormal_cell_proliferation1.70719505
29MP0008932_abnormal_embryonic_tissue1.68843267
30MP0008007_abnormal_cellular_replicative1.68449494
31MP0000579_abnormal_nail_morphology1.67191755
32* MP0005380_embryogenesis_phenotype1.62847645
33* MP0001672_abnormal_embryogenesis/_devel1.62847645
34MP0000467_abnormal_esophagus_morphology1.57869269
35MP0003123_paternal_imprinting1.55479299
36MP0009053_abnormal_anal_canal1.53818726
37MP0005257_abnormal_intraocular_pressure1.51538379
38MP0008058_abnormal_DNA_repair1.49554724
39MP0001293_anophthalmia1.48296891
40MP0004133_heterotaxia1.48032585
41MP0000490_abnormal_crypts_of1.47752003
42* MP0001697_abnormal_embryo_size1.47128342
43MP0004197_abnormal_fetal_growth/weight/1.45995211
44* MP0002086_abnormal_extraembryonic_tissu1.45952429
45MP0001849_ear_inflammation1.42866114
46MP0000383_abnormal_hair_follicle1.41376923
47* MP0003984_embryonic_growth_retardation1.40968646
48MP0000462_abnormal_digestive_system1.40783984
49MP0002254_reproductive_system_inflammat1.40526678
50* MP0002088_abnormal_embryonic_growth/wei1.38602558
51MP0002249_abnormal_larynx_morphology1.38220583
52MP0000538_abnormal_urinary_bladder1.36102650
53MP0002089_abnormal_postnatal_growth/wei1.35067965
54MP0003937_abnormal_limbs/digits/tail_de1.32962637
55MP0010678_abnormal_skin_adnexa1.32229609
56MP0008004_abnormal_stomach_pH1.30689657
57MP0003136_yellow_coat_color1.30517037
58MP0005360_urolithiasis1.30453993
59MP0003718_maternal_effect1.28327330
60MP0000003_abnormal_adipose_tissue1.28189110
61MP0009384_cardiac_valve_regurgitation1.28099684
62MP0005409_darkened_coat_color1.27823692
63MP0002098_abnormal_vibrissa_morphology1.24471102
64MP0004381_abnormal_hair_follicle1.24133080
65* MP0002080_prenatal_lethality1.21965367
66MP0002111_abnormal_tail_morphology1.20193304
67MP0002796_impaired_skin_barrier1.20000463
68MP0009379_abnormal_foot_pigmentation1.17379833
69MP0006292_abnormal_olfactory_placode1.16619356
70MP0005501_abnormal_skin_physiology1.15452252
71MP0001664_abnormal_digestion1.14623806
72MP0003453_abnormal_keratinocyte_physiol1.14205788
73MP0010771_integument_phenotype1.13073121
74MP0000428_abnormal_craniofacial_morphol1.10996679
75MP0003315_abnormal_perineum_morphology1.09841149
76MP0005248_abnormal_Harderian_gland1.09703294
77MP0010307_abnormal_tumor_latency1.09318869
78MP0003786_premature_aging1.08638887
79MP0005367_renal/urinary_system_phenotyp1.08503432
80MP0000516_abnormal_urinary_system1.08503432
81MP0004272_abnormal_basement_membrane1.06862090
82MP0001346_abnormal_lacrimal_gland1.05513794
83MP0002736_abnormal_nociception_after1.03994854
84MP0003935_abnormal_craniofacial_develop1.03669520
85MP0002877_abnormal_melanocyte_morpholog1.03493449
86MP0005666_abnormal_adipose_tissue1.01568355
87MP0003121_genomic_imprinting1.00822433
88MP0001873_stomach_inflammation1.00809944
89MP0000432_abnormal_head_morphology1.00594165
90MP0002697_abnormal_eye_size1.00457662
91MP0010234_abnormal_vibrissa_follicle1.00366390
92MP0004185_abnormal_adipocyte_glucose1.00023719
93MP0001286_abnormal_eye_development0.99812497
94MP0000377_abnormal_hair_follicle0.98572092
95MP0005451_abnormal_body_composition0.97099442
96MP0005375_adipose_tissue_phenotype0.96270259
97MP0002092_abnormal_eye_morphology0.96033837
98MP0001216_abnormal_epidermal_layer0.95626066
99MP0008875_abnormal_xenobiotic_pharmacok0.94982900
100MP0000762_abnormal_tongue_morphology0.92952781
101MP0003115_abnormal_respiratory_system0.92855109
102MP0009278_abnormal_bone_marrow0.92529448
103MP0000049_abnormal_middle_ear0.92455764
104MP0003755_abnormal_palate_morphology0.91341321
105MP0002932_abnormal_joint_morphology0.90637450
106* MP0000313_abnormal_cell_death0.88722071
107MP0000470_abnormal_stomach_morphology0.85390095
108MP0001348_abnormal_lacrimal_gland0.84248517
109MP0002116_abnormal_craniofacial_bone0.83901361
110* MP0003861_abnormal_nervous_system0.83577515
111* MP0003566_abnormal_cell_adhesion0.83302448
112MP0005023_abnormal_wound_healing0.83295213
113MP0002938_white_spotting0.82821924
114MP0001188_hyperpigmentation0.82584845
115MP0001881_abnormal_mammary_gland0.82005322
116MP0003567_abnormal_fetal_cardiomyocyte0.81982694
117MP0000477_abnormal_intestine_morphology0.81890784
118MP0002210_abnormal_sex_determination0.81616398
119MP0004782_abnormal_surfactant_physiolog0.81161006
120MP0002060_abnormal_skin_morphology0.81109486
121MP0000733_abnormal_muscle_development0.80865867
122MP0002233_abnormal_nose_morphology0.79982932
123MP0003936_abnormal_reproductive_system0.79387252
124MP0002909_abnormal_adrenal_gland0.79299289
125MP0001915_intracranial_hemorrhage0.79167152
126MP0000613_abnormal_salivary_gland0.78477820
127MP0005171_absent_coat_pigmentation0.77907633
128MP0003942_abnormal_urinary_system0.77589600
129MP0002822_catalepsy0.77129847
130MP0004233_abnormal_muscle_weight0.76443727
131MP0000534_abnormal_ureter_morphology0.76045623
132MP0003938_abnormal_ear_development0.75940781
133MP0001145_abnormal_male_reproductive0.75031185
134* MP0002925_abnormal_cardiovascular_devel0.74697411
135MP0005220_abnormal_exocrine_pancreas0.74609850
136MP0002019_abnormal_tumor_incidence0.74489774
137MP0009672_abnormal_birth_weight0.74292310
138MP0001968_abnormal_touch/_nociception0.73079498
139MP0000627_abnormal_mammary_gland0.70839962
140MP0001944_abnormal_pancreas_morphology0.70580936
141MP0005623_abnormal_meninges_morphology0.69665891
142MP0002160_abnormal_reproductive_system0.67784090

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)3.76290052
2Testicular atrophy (HP:0000029)3.68817555
3Ependymoma (HP:0002888)3.38897368
4Septate vagina (HP:0001153)3.16154554
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15560147
6Breast hypoplasia (HP:0003187)3.07200996
7Rib fusion (HP:0000902)3.07082985
8Chromsome breakage (HP:0040012)3.03292523
9Absent radius (HP:0003974)3.02304724
10Patellar aplasia (HP:0006443)2.93047176
11Shawl scrotum (HP:0000049)2.91348454
12Absent forearm bone (HP:0003953)2.87800543
13Aplasia involving forearm bones (HP:0009822)2.87800543
14Concave nail (HP:0001598)2.84265213
15Stridor (HP:0010307)2.81926114
16Hyperacusis (HP:0010780)2.81459420
17Selective tooth agenesis (HP:0001592)2.77015981
18Alopecia of scalp (HP:0002293)2.72496721
19Aplasia/Hypoplasia of the patella (HP:0006498)2.69064242
20Medulloblastoma (HP:0002885)2.64670005
21Adenoma sebaceum (HP:0009720)2.61324926
22Angiofibromas (HP:0010615)2.61324926
23Abnormality of the phalanges of the hallux (HP:0010057)2.49351101
24Abnormality of the labia minora (HP:0012880)2.44221366
25Ectopic kidney (HP:0000086)2.43634211
26Bronchomalacia (HP:0002780)2.42593082
27Aplasia/hypoplasia of the humerus (HP:0006507)2.39931329
28Broad face (HP:0000283)2.37733001
29Esophageal atresia (HP:0002032)2.37027864
30Abnormality of the astrocytes (HP:0100707)2.34532719
31Astrocytoma (HP:0009592)2.34532719
32Abnormal number of incisors (HP:0011064)2.34217514
33Short humerus (HP:0005792)2.31442504
34Birth length less than 3rd percentile (HP:0003561)2.27022356
35Flat acetabular roof (HP:0003180)2.25264728
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.23273855
37Neoplasm of the oral cavity (HP:0100649)2.23196094
38Broad distal phalanx of finger (HP:0009836)2.22259294
39Abnormality of the ileum (HP:0001549)2.19246928
40Pterygium (HP:0001059)2.18582837
41Deviation of the thumb (HP:0009603)2.18424476
42Proximal placement of thumb (HP:0009623)2.17359617
43Agnosia (HP:0010524)2.17311130
44Rhabdomyosarcoma (HP:0002859)2.16517791
45Thin bony cortex (HP:0002753)2.16321753
46Lymphangioma (HP:0100764)2.15336588
47Obstructive sleep apnea (HP:0002870)2.13380213
48Shallow orbits (HP:0000586)2.12488311
49Abnormality of the distal phalanges of the toes (HP:0010182)2.11855564
50Abdominal situs inversus (HP:0003363)2.11401331
51Abnormality of abdominal situs (HP:0011620)2.11401331
52Malignant gastrointestinal tract tumors (HP:0006749)2.11191759
53Gastrointestinal carcinoma (HP:0002672)2.11191759
54Neoplasm of striated muscle (HP:0009728)2.08476384
55Meckel diverticulum (HP:0002245)2.07017712
56Pili torti (HP:0003777)2.06649528
57Bilateral sensorineural hearing impairment (HP:0008619)2.06605368
58Trismus (HP:0000211)2.06579643
59Partial duplication of thumb phalanx (HP:0009944)2.06388297
60Abnormality of the aortic arch (HP:0012303)2.05651902
61Amelogenesis imperfecta (HP:0000705)2.04154192
62Premature skin wrinkling (HP:0100678)2.01792829
63Flattened epiphyses (HP:0003071)2.00979263
64Blepharitis (HP:0000498)1.99666852
65Glioma (HP:0009733)1.99432407
66Supernumerary spleens (HP:0009799)1.98650572
67Pendular nystagmus (HP:0012043)1.98220025
68Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.97855466
69J-shaped sella turcica (HP:0002680)1.96915575
70Missing ribs (HP:0000921)1.95669957
71Hemivertebrae (HP:0002937)1.95461369
72Distal upper limb amyotrophy (HP:0007149)1.95427010
73Upper limb amyotrophy (HP:0009129)1.95427010
74Vertebral clefting (HP:0008428)1.95011050
75Hyperthyroidism (HP:0000836)1.94083294
76Carpal bone hypoplasia (HP:0001498)1.93995015
77Gastrointestinal atresia (HP:0002589)1.93848479
78Germ cell neoplasia (HP:0100728)1.91442099
79Skull defect (HP:0001362)1.91400120
80Congenital glaucoma (HP:0001087)1.90383398
81Small intestinal stenosis (HP:0012848)1.88825293
82Duodenal stenosis (HP:0100867)1.88825293
83High anterior hairline (HP:0009890)1.88376952
84Turricephaly (HP:0000262)1.87284367
85Abdominal distention (HP:0003270)1.85904933
86Abnormality of the salivary glands (HP:0010286)1.85734187
87Abnormality of the preputium (HP:0100587)1.85021012
88Biliary tract neoplasm (HP:0100574)1.85010255
89Intestinal fistula (HP:0100819)1.84210307
90Rectal prolapse (HP:0002035)1.84034011
91Anal stenosis (HP:0002025)1.84021529
92Partial duplication of the phalanx of hand (HP:0009999)1.83248477
93Ulnar bowing (HP:0003031)1.82785705
94Atresia of the external auditory canal (HP:0000413)1.82444348
95Advanced eruption of teeth (HP:0006288)1.81442966
96Vertebral fusion (HP:0002948)1.80948322
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80701262
98Increased nuchal translucency (HP:0010880)1.80495558
99Renal duplication (HP:0000075)1.80453808
100Neoplasm of the pancreas (HP:0002894)1.80087138
101Abnormality of the anterior horn cell (HP:0006802)1.79626688
102Degeneration of anterior horn cells (HP:0002398)1.79626688
103Mildly elevated creatine phosphokinase (HP:0008180)1.79608449
104Abnormality of chromosome stability (HP:0003220)1.78625304
105Breast aplasia (HP:0100783)1.78277724
106Urethral obstruction (HP:0000796)1.78213032
107Spinal muscular atrophy (HP:0007269)1.78154800
108Focal segmental glomerulosclerosis (HP:0000097)1.76532198
109Nasolacrimal duct obstruction (HP:0000579)1.76403349
110Absent thumb (HP:0009777)1.75751511
111Aplasia involving bones of the extremities (HP:0009825)1.75686744
112Aplasia involving bones of the upper limbs (HP:0009823)1.75686744
113Aplasia of the phalanges of the hand (HP:0009802)1.75686744
114Abnormality of the distal phalanx of the thumb (HP:0009617)1.75677412
115Cheilitis (HP:0100825)1.75230076
116Sparse lateral eyebrow (HP:0005338)1.75067101
117Rectovaginal fistula (HP:0000143)1.75037214
118Rectal fistula (HP:0100590)1.75037214
119Difficulty climbing stairs (HP:0003551)1.74524405
120Short thumb (HP:0009778)1.73537820
121Bowed forearm bones (HP:0003956)1.73509555
122Bowing of the arm (HP:0006488)1.73509555
123Tracheal stenosis (HP:0002777)1.73478787
124Abnormality of the duodenum (HP:0002246)1.72944361
125Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.72782261
126Absent eyebrow (HP:0002223)1.72223709
127Rough bone trabeculation (HP:0100670)1.71981130
128Microretrognathia (HP:0000308)1.71805931
129Impulsivity (HP:0100710)1.71581643
130Abnormal number of erythroid precursors (HP:0012131)1.71122852
131Intestinal atresia (HP:0011100)1.71078443
132Aplasia/Hypoplasia of the breasts (HP:0010311)1.70940751
133Right ventricular cardiomyopathy (HP:0011663)1.70820914
134Easy fatigability (HP:0003388)1.69018661
135Uterine neoplasm (HP:0010784)1.68710359
136Hypoplastic labia majora (HP:0000059)1.66579401
137Hypoplasia of the radius (HP:0002984)1.66146088
138Short phalanx of the thumb (HP:0009660)1.66088059
139Overlapping toe (HP:0001845)1.65930207
140Bifid scrotum (HP:0000048)1.65796832
141Facial hemangioma (HP:0000329)1.65679955
142Spinal cord compression (HP:0002176)1.64609634
143Tracheoesophageal fistula (HP:0002575)1.63924674
144Supernumerary ribs (HP:0005815)1.63414107
145Acanthosis nigricans (HP:0000956)1.63324636
146Duplicated collecting system (HP:0000081)1.63257222
147Hemorrhage of the eye (HP:0011885)1.62648835
148Absent eyelashes (HP:0000561)1.61995291
149Diaphragmatic weakness (HP:0009113)1.61711390
150Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61668075
151Absent epiphyses (HP:0010577)1.61668075
152Aplasia cutis congenita (HP:0001057)1.61617753
153Long palpebral fissure (HP:0000637)1.61525530
154Choanal atresia (HP:0000453)1.61506114
155Distal lower limb amyotrophy (HP:0008944)1.61395389
156Cervical subluxation (HP:0003308)1.60608020
157Short nail (HP:0001799)1.60551281
158Premature ovarian failure (HP:0008209)1.60483920
159Vaginal fistula (HP:0004320)1.60382079
160Renal dysplasia (HP:0000110)1.60184949
161Oral leukoplakia (HP:0002745)1.59551739
162Bicornuate uterus (HP:0000813)1.58958505
163Short 4th metacarpal (HP:0010044)1.58810418
164Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.58810418
165Horseshoe kidney (HP:0000085)1.58432329
166Fragile nails (HP:0001808)1.56190741
167Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.55904036
168Achilles tendon contracture (HP:0001771)1.55199842
169Late onset (HP:0003584)1.55118277
170Abnormality of the lacrimal duct (HP:0011481)1.54878846
171Cerebellar dysplasia (HP:0007033)1.53420392
172Coronal craniosynostosis (HP:0004440)1.52084788
173Myopathic facies (HP:0002058)1.51865762
174Patellar dislocation (HP:0002999)1.51395436
175Choanal stenosis (HP:0000452)1.50819930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.53833111
2CDK124.10121735
3PASK3.49546539
4LATS13.44678876
5BUB13.24429757
6SMG13.22711128
7SIK33.14679026
8IRAK33.12839255
9NEK22.58856992
10MST1R2.51466463
11CDC72.48848966
12TTK2.47318071
13STK38L2.20840640
14VRK22.17028878
15LATS22.12985711
16CDK72.05942808
17SIK12.04492592
18LMTK21.97169598
19PRKD31.93455128
20CAMK1D1.92521518
21MAP3K101.85916114
22EEF2K1.77284330
23WEE11.77188307
24NME21.75359087
25CDK81.70832630
26RPS6KB21.69075450
27ICK1.57907549
28ERN11.54455723
29PLK11.50647301
30CHEK21.47862595
31STK101.40148914
32MUSK1.33924478
33NEK11.33878735
34STK31.31743210
35DYRK31.28935417
36CDK41.24461366
37AURKB1.22898134
38MAP2K21.21629035
39PLK41.21449160
40ILK1.17588195
41EPHB21.17188154
42PRKD21.14602635
43MAPKAPK31.14053554
44CAMK1G1.12624931
45MAP3K81.12514719
46SRPK11.11623246
47MTOR1.09707193
48TRIB31.06580145
49CHEK11.05920437
50BRD41.05805301
51ATR1.03024106
52PRKCI0.97011476
53NME10.95509849
54DDR20.93548200
55AURKA0.92558316
56WNK40.91957599
57MELK0.90527159
58IRAK20.89232490
59RPS6KA40.88894522
60RPS6KA20.88570647
61FGFR40.86589906
62PTK20.85441538
63TESK20.84466837
64MET0.84309923
65PKN20.82644214
66MAP3K110.81215119
67STK40.80986809
68ACVR1B0.80772999
69BRAF0.80580608
70TAOK20.80170898
71ERBB40.78021288
72BRSK20.77431548
73PDGFRA0.76134113
74TYRO30.75450086
75MARK30.75331863
76AKT30.73916209
77MAP4K20.72731254
78PRKG20.71448666
79PIM10.70890107
80CDK20.69203507
81ARAF0.68952395
82CDK60.68429341
83ATM0.65950628
84MAPK150.65657854
85BMX0.63248909
86FLT30.62568429
87LIMK10.61663480
88TLK10.60899661
89MAPK110.60688745
90PIM20.60398213
91TNK20.59313869
92TESK10.59282662
93CDK90.59015574
94HIPK20.58559609
95PHKG20.57272785
96PHKG10.57272785
97BRSK10.57079996
98PTK60.56618010
99AKT20.56088503
100TSSK60.56085259
101TAOK10.55670683
102KSR10.54147712
103CHUK0.53636299
104RPS6KA60.52377834
105EIF2AK10.52218680
106RIPK10.51026814
107DAPK10.50455822
108RPS6KC10.50267644
109RPS6KL10.50267644
110* PAK40.50260509
111PLK30.49941291
112PAK10.49711449
113FER0.48887385
114ERBB20.48759306
115SIK20.48669552
116MATK0.48549760
117TAF10.47914317
118FGFR10.47197120
119MAP3K60.46287561
120DYRK1B0.46252293
121CDK10.44709929
122BCKDK0.44517733
123PDPK10.43562201
124MKNK20.42826240
125EPHB10.41968196
126MARK20.41450961
127PRKAA10.41040513
128BCR0.40750892
129ALK0.40048340
130TGFBR10.37581616
131MAP3K30.35840925
132TTN0.35201787
133AKT10.35144057
134CAMK2B0.34389684
135RPS6KA10.34174207
136SCYL20.33958716
137STK380.33871236
138CSNK1E0.33058068
139CAMK2G0.31902563
140MAP2K10.27841681
141STK390.27055759
142MAPKAPK20.26549240
143IRAK10.26432031
144MAP2K60.24767458
145MAPK80.24316694
146CAMK2D0.23902262
147FGFR20.23660454
148NTRK10.22640864

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.34560888
2DNA replication_Homo sapiens_hsa030303.30073377
3Mismatch repair_Homo sapiens_hsa034303.08369104
4Cell cycle_Homo sapiens_hsa041103.02215411
5RNA transport_Homo sapiens_hsa030132.80071540
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.71486349
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.70368224
8Spliceosome_Homo sapiens_hsa030402.61982205
9Base excision repair_Homo sapiens_hsa034102.46611194
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.20632663
11Homologous recombination_Homo sapiens_hsa034402.17119897
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.15117403
13Basal cell carcinoma_Homo sapiens_hsa052172.13166252
14One carbon pool by folate_Homo sapiens_hsa006702.13010689
15Notch signaling pathway_Homo sapiens_hsa043302.08127024
16p53 signaling pathway_Homo sapiens_hsa041151.94089731
17Hippo signaling pathway_Homo sapiens_hsa043901.92217382
18mRNA surveillance pathway_Homo sapiens_hsa030151.89183037
19Fanconi anemia pathway_Homo sapiens_hsa034601.85644600
20Nucleotide excision repair_Homo sapiens_hsa034201.85127141
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84222037
22Basal transcription factors_Homo sapiens_hsa030221.73786577
23Bladder cancer_Homo sapiens_hsa052191.72092181
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.71970994
25Hedgehog signaling pathway_Homo sapiens_hsa043401.67277399
26RNA polymerase_Homo sapiens_hsa030201.66972663
27Fatty acid biosynthesis_Homo sapiens_hsa000611.61990653
28RNA degradation_Homo sapiens_hsa030181.60175487
29Adherens junction_Homo sapiens_hsa045201.60136191
30* MicroRNAs in cancer_Homo sapiens_hsa052061.46988955
31Vitamin digestion and absorption_Homo sapiens_hsa049771.44870831
32Phenylalanine metabolism_Homo sapiens_hsa003601.43715798
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.41984977
34Lysine degradation_Homo sapiens_hsa003101.36073645
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.34200655
36Pyrimidine metabolism_Homo sapiens_hsa002401.32026201
37Selenocompound metabolism_Homo sapiens_hsa004501.31300593
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30570147
39Small cell lung cancer_Homo sapiens_hsa052221.29855057
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28968736
41Folate biosynthesis_Homo sapiens_hsa007901.24442919
42TGF-beta signaling pathway_Homo sapiens_hsa043501.22406913
43Thyroid cancer_Homo sapiens_hsa052161.21740185
44Arginine biosynthesis_Homo sapiens_hsa002201.18689472
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.14218133
46Pyruvate metabolism_Homo sapiens_hsa006201.08957881
47Non-homologous end-joining_Homo sapiens_hsa034501.06743259
48HTLV-I infection_Homo sapiens_hsa051661.06192484
49Tight junction_Homo sapiens_hsa045301.01269065
50Sulfur relay system_Homo sapiens_hsa041220.99033720
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96044900
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94350839
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93988487
54Viral carcinogenesis_Homo sapiens_hsa052030.93727078
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93676590
56Chronic myeloid leukemia_Homo sapiens_hsa052200.88197816
57mTOR signaling pathway_Homo sapiens_hsa041500.86993872
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85804149
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85556344
60Wnt signaling pathway_Homo sapiens_hsa043100.85460248
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85000574
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83687556
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83558341
64* Axon guidance_Homo sapiens_hsa043600.82477374
65Colorectal cancer_Homo sapiens_hsa052100.82146968
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79285763
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79142525
68Tyrosine metabolism_Homo sapiens_hsa003500.78291047
69Insulin signaling pathway_Homo sapiens_hsa049100.77412833
70Herpes simplex infection_Homo sapiens_hsa051680.77370816
71Histidine metabolism_Homo sapiens_hsa003400.77098022
72Pathways in cancer_Homo sapiens_hsa052000.77006459
73Mineral absorption_Homo sapiens_hsa049780.76508868
74Epstein-Barr virus infection_Homo sapiens_hsa051690.76409207
75VEGF signaling pathway_Homo sapiens_hsa043700.76341559
76Glucagon signaling pathway_Homo sapiens_hsa049220.74536812
77Melanoma_Homo sapiens_hsa052180.73970175
78Endometrial cancer_Homo sapiens_hsa052130.73925504
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72469953
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72103531
81Fructose and mannose metabolism_Homo sapiens_hsa000510.71511543
82Ribosome_Homo sapiens_hsa030100.71360924
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70069592
84Carbon metabolism_Homo sapiens_hsa012000.70012780
85Pancreatic cancer_Homo sapiens_hsa052120.69877138
86Bile secretion_Homo sapiens_hsa049760.69566048
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69223240
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68364770
89Apoptosis_Homo sapiens_hsa042100.67052613
90Prostate cancer_Homo sapiens_hsa052150.66086795
91Linoleic acid metabolism_Homo sapiens_hsa005910.65846310
92Proteoglycans in cancer_Homo sapiens_hsa052050.65345815
93Arginine and proline metabolism_Homo sapiens_hsa003300.65236092
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.64871360
95Vibrio cholerae infection_Homo sapiens_hsa051100.64766067
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64693818
97Oocyte meiosis_Homo sapiens_hsa041140.63755239
98Biosynthesis of amino acids_Homo sapiens_hsa012300.63527561
99Melanogenesis_Homo sapiens_hsa049160.62274745
100Sulfur metabolism_Homo sapiens_hsa009200.61896827
101Fat digestion and absorption_Homo sapiens_hsa049750.61876396
102Insulin resistance_Homo sapiens_hsa049310.61842000
103Acute myeloid leukemia_Homo sapiens_hsa052210.57659316
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57464058
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56422686
106Proteasome_Homo sapiens_hsa030500.56231898
107Steroid biosynthesis_Homo sapiens_hsa001000.55993477
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55387019
109Vitamin B6 metabolism_Homo sapiens_hsa007500.53434503
110Sphingolipid metabolism_Homo sapiens_hsa006000.52932715
111ABC transporters_Homo sapiens_hsa020100.52456587
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52044240
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.51512104
114Fatty acid metabolism_Homo sapiens_hsa012120.51308313
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49864614
116Purine metabolism_Homo sapiens_hsa002300.49624394
117Metabolic pathways_Homo sapiens_hsa011000.49327451
118Estrogen signaling pathway_Homo sapiens_hsa049150.48682623
119Galactose metabolism_Homo sapiens_hsa000520.48219121
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47961224
121Legionellosis_Homo sapiens_hsa051340.46719398
122Glutathione metabolism_Homo sapiens_hsa004800.46662116
123Taste transduction_Homo sapiens_hsa047420.46460631
124Shigellosis_Homo sapiens_hsa051310.45963453
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44496609
126Pentose phosphate pathway_Homo sapiens_hsa000300.42590193
127Dorso-ventral axis formation_Homo sapiens_hsa043200.41753024
128N-Glycan biosynthesis_Homo sapiens_hsa005100.41261156
129* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41160944
130Renin-angiotensin system_Homo sapiens_hsa046140.39710664
131Systemic lupus erythematosus_Homo sapiens_hsa053220.39578350
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.39404659
133Protein digestion and absorption_Homo sapiens_hsa049740.39223870
134ECM-receptor interaction_Homo sapiens_hsa045120.38109158
135Hepatitis B_Homo sapiens_hsa051610.37233563
136Non-small cell lung cancer_Homo sapiens_hsa052230.36402423
137FoxO signaling pathway_Homo sapiens_hsa040680.34939742
138Circadian rhythm_Homo sapiens_hsa047100.34904352
139Prolactin signaling pathway_Homo sapiens_hsa049170.33608048
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32706996
141Arachidonic acid metabolism_Homo sapiens_hsa005900.32197991
142HIF-1 signaling pathway_Homo sapiens_hsa040660.31205373
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.29068409
144AMPK signaling pathway_Homo sapiens_hsa041520.28857951
145Antigen processing and presentation_Homo sapiens_hsa046120.28062068
146Drug metabolism - other enzymes_Homo sapiens_hsa009830.25990633

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