PAK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.72549087
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.14067271
3locomotory exploration behavior (GO:0035641)5.90337693
4vocalization behavior (GO:0071625)5.73597605
5layer formation in cerebral cortex (GO:0021819)5.61576032
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56073700
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.53077901
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39028689
9glutamate secretion (GO:0014047)5.31939590
10protein localization to synapse (GO:0035418)5.06180502
11exploration behavior (GO:0035640)5.00142354
12regulation of glutamate receptor signaling pathway (GO:1900449)4.99783089
13proline transport (GO:0015824)4.98960030
14synaptic vesicle exocytosis (GO:0016079)4.98601767
15pyrimidine nucleobase catabolic process (GO:0006208)4.96549402
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.87154248
17neuron cell-cell adhesion (GO:0007158)4.77063881
18regulation of synaptic vesicle exocytosis (GO:2000300)4.75941529
19dendritic spine morphogenesis (GO:0060997)4.72281317
20regulation of synapse structural plasticity (GO:0051823)4.70017451
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.39199878
22neurotransmitter-gated ion channel clustering (GO:0072578)4.28528894
23regulation of neuronal synaptic plasticity (GO:0048168)4.24552004
24nucleobase catabolic process (GO:0046113)4.18994724
25regulation of synaptic vesicle transport (GO:1902803)4.18898036
26neurotransmitter secretion (GO:0007269)4.15158936
27positive regulation of synapse maturation (GO:0090129)4.09358338
28postsynaptic membrane organization (GO:0001941)4.08147674
29ionotropic glutamate receptor signaling pathway (GO:0035235)4.00534108
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98767435
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.89578300
32dendrite morphogenesis (GO:0048813)3.87311622
33central nervous system projection neuron axonogenesis (GO:0021952)3.81562862
34mitochondrion transport along microtubule (GO:0047497)3.78970057
35establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.78970057
36neuron recognition (GO:0008038)3.78819937
37synaptic transmission, glutamatergic (GO:0035249)3.76996749
38auditory behavior (GO:0031223)3.75667932
39gamma-aminobutyric acid transport (GO:0015812)3.74771970
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68598415
41regulation of dendritic spine morphogenesis (GO:0061001)3.67042484
42cell migration in hindbrain (GO:0021535)3.66171356
43regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.65227564
44chemosensory behavior (GO:0007635)3.63563315
45positive regulation of membrane potential (GO:0045838)3.61506607
46activation of protein kinase A activity (GO:0034199)3.60676216
47axonal fasciculation (GO:0007413)3.55441651
48long-term memory (GO:0007616)3.53119561
49glutamate receptor signaling pathway (GO:0007215)3.52961881
50establishment of mitochondrion localization (GO:0051654)3.46086642
51neuron-neuron synaptic transmission (GO:0007270)3.43094643
52regulation of voltage-gated calcium channel activity (GO:1901385)3.40750720
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34589216
54response to auditory stimulus (GO:0010996)3.32565352
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.32114956
56clathrin coat assembly (GO:0048268)3.31834522
57neuromuscular process controlling balance (GO:0050885)3.30712921
58cellular sodium ion homeostasis (GO:0006883)3.29863833
59dendritic spine organization (GO:0097061)3.29044435
60organelle transport along microtubule (GO:0072384)3.28562693
61regulation of heart rate by cardiac conduction (GO:0086091)3.28372473
62axon extension (GO:0048675)3.27025314
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27006574
64negative regulation of dendrite morphogenesis (GO:0050774)3.25596648
65regulation of synaptic plasticity (GO:0048167)3.25547783
66neurotransmitter transport (GO:0006836)3.25526332
67neuronal action potential propagation (GO:0019227)3.24172776
68cardiac conduction (GO:0061337)3.23406562
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21433570
70positive regulation of neurotransmitter secretion (GO:0001956)3.18457013
71regulation of postsynaptic membrane potential (GO:0060078)3.17880574
72membrane depolarization during action potential (GO:0086010)3.15281848
73regulation of dendritic spine development (GO:0060998)3.14611876
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13940173
75regulation of neurotransmitter secretion (GO:0046928)3.13531612
76synapse assembly (GO:0007416)3.12908632
77positive regulation of axon extension (GO:0045773)3.12722347
78positive regulation of dendritic spine morphogenesis (GO:0061003)3.12600150
79positive regulation of dendritic spine development (GO:0060999)3.11753372
80vesicle transport along microtubule (GO:0047496)3.11384857
81cell communication involved in cardiac conduction (GO:0086065)3.10503710
82detection of calcium ion (GO:0005513)3.10479402
83dopamine receptor signaling pathway (GO:0007212)3.09297870
84adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.07735218
85cell communication by electrical coupling (GO:0010644)3.07611309
86sodium ion export (GO:0071436)3.07523898
87regulation of synapse maturation (GO:0090128)3.07377835
88signal release (GO:0023061)3.06441111
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.03671271
90regulation of female receptivity (GO:0045924)3.02143766
91regulation of vesicle fusion (GO:0031338)3.01682855
92neuron projection extension (GO:1990138)3.00688545
93behavioral fear response (GO:0001662)2.99079127
94behavioral defense response (GO:0002209)2.99079127
95synaptic transmission (GO:0007268)2.98930666
96social behavior (GO:0035176)2.98544580
97intraspecies interaction between organisms (GO:0051703)2.98544580
98cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96954424
99synaptic vesicle endocytosis (GO:0048488)2.96904173
100cellular potassium ion homeostasis (GO:0030007)2.95734702
101positive regulation of neurotransmitter transport (GO:0051590)2.95607842
102regulation of neurotransmitter levels (GO:0001505)2.93866658
103regulation of calcium ion-dependent exocytosis (GO:0017158)2.93782703
104regulation of cAMP-dependent protein kinase activity (GO:2000479)2.93057004
105neuronal ion channel clustering (GO:0045161)2.92968457
106membrane depolarization (GO:0051899)2.92844927
107potassium ion homeostasis (GO:0055075)2.92630174
108central nervous system neuron axonogenesis (GO:0021955)2.91954137
109glycine transport (GO:0015816)2.91134901
110presynaptic membrane organization (GO:0097090)2.91095973
111cochlea development (GO:0090102)2.90457893
112neuromuscular synaptic transmission (GO:0007274)2.90212922
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.89690179
114synapse organization (GO:0050808)2.89578047
115transmission of nerve impulse (GO:0019226)2.88915267
116negative regulation of microtubule polymerization (GO:0031115)2.88410851
117learning (GO:0007612)2.88201418
118multicellular organismal signaling (GO:0035637)2.87884754
119innervation (GO:0060384)2.87681598
120presynaptic membrane assembly (GO:0097105)2.87663026
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84385862
122cerebellar granule cell differentiation (GO:0021707)2.84282113
123cerebral cortex neuron differentiation (GO:0021895)2.82974568
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.82033631
125regulation of neurotransmitter transport (GO:0051588)2.81580550
126atrial cardiac muscle cell action potential (GO:0086014)2.80052102
127desmosome organization (GO:0002934)2.79246747
128mechanosensory behavior (GO:0007638)2.76476275
129negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76373597
130regulation of exocytosis (GO:0017157)2.74596660
131regulation of synaptic transmission (GO:0050804)2.74269923
132establishment of synaptic vesicle localization (GO:0097480)2.69571677
133synaptic vesicle transport (GO:0048489)2.69571677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49244786
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.05110699
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98971744
4GBX2_23144817_ChIP-Seq_PC3_Human2.85677871
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.78177739
6REST_21632747_ChIP-Seq_MESCs_Mouse2.78021955
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67132716
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67132716
9RARB_27405468_Chip-Seq_BRAIN_Mouse2.66733078
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.54920446
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54187247
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48599667
13DROSHA_22980978_ChIP-Seq_HELA_Human2.44583415
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42375913
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.42274455
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38910181
17* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.34135760
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.31495146
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29975802
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29777819
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.29716758
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.28561277
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.25996787
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21383629
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.01556328
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99788109
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97497074
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.96827365
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.95248797
30AR_21572438_ChIP-Seq_LNCaP_Human1.89812045
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77831370
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.72734189
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65741575
34TAF15_26573619_Chip-Seq_HEK293_Human1.59993461
35KDM2B_26808549_Chip-Seq_K562_Human1.53538153
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51571474
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.49101519
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48157110
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47913719
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46762328
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41987611
42* RING1B_27294783_Chip-Seq_NPCs_Mouse1.41159857
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34166313
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33286330
45SMAD4_21799915_ChIP-Seq_A2780_Human1.32131636
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.31327450
47* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28680358
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27250012
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27057969
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.25338643
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23974028
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20883090
53AR_19668381_ChIP-Seq_PC3_Human1.20673615
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20260526
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19963950
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19310692
57RNF2_27304074_Chip-Seq_NSC_Mouse1.18274511
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16698480
59AHR_22903824_ChIP-Seq_MCF-7_Human1.14981133
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.13931034
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12008595
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11392901
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10707096
64RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09970832
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09419227
66SMAD3_21741376_ChIP-Seq_HESCs_Human1.07885972
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07638785
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06603279
69NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05512464
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04871196
71ZNF274_21170338_ChIP-Seq_K562_Hela1.04471973
72IGF1R_20145208_ChIP-Seq_DFB_Human1.03560976
73SMAD4_21741376_ChIP-Seq_HESCs_Human1.03134704
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02789258
75STAT3_23295773_ChIP-Seq_U87_Human1.02557942
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.02091738
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00724597
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00081792
79TP53_20018659_ChIP-ChIP_R1E_Mouse0.99469282
80CTCF_27219007_Chip-Seq_Bcells_Human0.99373679
81AR_25329375_ChIP-Seq_VCAP_Human0.98710060
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97995248
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97918371
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97902442
85* TET1_21490601_ChIP-Seq_MESCs_Mouse0.97730097
86* CBX2_27304074_Chip-Seq_ESCs_Mouse0.97586287
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96651863
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96218737
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95861071
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94665918
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94055948
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92902477
93SMAD_19615063_ChIP-ChIP_OVARY_Human0.90656102
94SMAD3_21741376_ChIP-Seq_ESCs_Human0.89562285
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89206368
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89163730
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88776065
98HTT_18923047_ChIP-ChIP_STHdh_Human0.87708859
99ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87248209
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86884658
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86884658
102PIAS1_25552417_ChIP-Seq_VCAP_Human0.86255697
103RUNX2_22187159_ChIP-Seq_PCA_Human0.85725358
104NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.85442093
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84139736
106P300_19829295_ChIP-Seq_ESCs_Human0.83823295
107SMC4_20622854_ChIP-Seq_HELA_Human0.83820287
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83396375
109TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83122744
110TP53_22573176_ChIP-Seq_HFKS_Human0.82224157
111TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81321289
112TCF4_23295773_ChIP-Seq_U87_Human0.81086502
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.80655827
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.80628688
115DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80481130
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.80359192
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80342232
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77748459
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76456626
120OCT4_19829295_ChIP-Seq_ESCs_Human0.76142914
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.75745182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.89025547
2MP0004270_analgesia4.21491800
3MP0003635_abnormal_synaptic_transmissio4.07619565
4MP0003880_abnormal_central_pattern3.72633451
5* MP0002063_abnormal_learning/memory/cond3.40866973
6MP0005423_abnormal_somatic_nervous3.12352106
7MP0009745_abnormal_behavioral_response3.08803452
8MP0002734_abnormal_mechanical_nocicepti2.80128026
9MP0004858_abnormal_nervous_system2.70871168
10MP0002064_seizures2.69654512
11* MP0002572_abnormal_emotion/affect_behav2.69129767
12MP0001968_abnormal_touch/_nociception2.60733579
13MP0009780_abnormal_chondrocyte_physiolo2.51066111
14MP0009046_muscle_twitch2.44067698
15MP0001486_abnormal_startle_reflex2.39363886
16MP0000778_abnormal_nervous_system2.36452996
17MP0002822_catalepsy2.22091430
18MP0002733_abnormal_thermal_nociception2.19551134
19MP0001440_abnormal_grooming_behavior2.17173806
20MP0002735_abnormal_chemical_nociception2.16127189
21MP0002909_abnormal_adrenal_gland1.99109126
22MP0004811_abnormal_neuron_physiology1.97374280
23MP0002184_abnormal_innervation1.94553840
24MP0003329_amyloid_beta_deposits1.93739732
25MP0001970_abnormal_pain_threshold1.91849960
26MP0002272_abnormal_nervous_system1.86512742
27* MP0002557_abnormal_social/conspecific_i1.78954333
28MP0002736_abnormal_nociception_after1.75585690
29MP0004924_abnormal_behavior1.75043915
30MP0005386_behavior/neurological_phenoty1.75043915
31MP0001501_abnormal_sleep_pattern1.71714083
32MP0000955_abnormal_spinal_cord1.71267617
33MP0002876_abnormal_thyroid_physiology1.62723365
34MP0005394_taste/olfaction_phenotype1.60157017
35MP0005499_abnormal_olfactory_system1.60157017
36MP0004885_abnormal_endolymph1.58223745
37MP0002067_abnormal_sensory_capabilities1.55396070
38MP0008877_abnormal_DNA_methylation1.52496498
39MP0008569_lethality_at_weaning1.51573611
40MP0003879_abnormal_hair_cell1.49945372
41MP0008961_abnormal_basal_metabolism1.41232312
42MP0003787_abnormal_imprinting1.41028542
43* MP0002882_abnormal_neuron_morphology1.39787076
44MP0001984_abnormal_olfaction1.37648577
45MP0003122_maternal_imprinting1.34533037
46MP0003123_paternal_imprinting1.30312111
47* MP0002066_abnormal_motor_capabilities/c1.28844837
48MP0006276_abnormal_autonomic_nervous1.24519915
49MP0005551_abnormal_eye_electrophysiolog1.21474437
50MP0001348_abnormal_lacrimal_gland1.19947299
51MP0002152_abnormal_brain_morphology1.19130004
52MP0010678_abnormal_skin_adnexa1.15208693
53MP0005645_abnormal_hypothalamus_physiol1.14228944
54MP0000569_abnormal_digit_pigmentation1.09585756
55MP0003137_abnormal_impulse_conducting1.09348336
56MP0000427_abnormal_hair_cycle1.07712541
57MP0000751_myopathy1.06557216
58MP0003633_abnormal_nervous_system1.05523143
59MP0000383_abnormal_hair_follicle1.04954134
60MP0000566_synostosis1.04347385
61MP0003121_genomic_imprinting1.04243750
62MP0004085_abnormal_heartbeat1.03463842
63MP0005646_abnormal_pituitary_gland1.02833088
64MP0001986_abnormal_taste_sensitivity1.01312382
65MP0001188_hyperpigmentation1.01148213
66MP0000631_abnormal_neuroendocrine_gland0.99275278
67MP0010234_abnormal_vibrissa_follicle0.98060171
68MP0010386_abnormal_urinary_bladder0.96379065
69MP0001905_abnormal_dopamine_level0.95234327
70MP0002069_abnormal_eating/drinking_beha0.92945788
71MP0002234_abnormal_pharynx_morphology0.92833379
72MP0003283_abnormal_digestive_organ0.90274868
73MP0003631_nervous_system_phenotype0.90204957
74MP0006072_abnormal_retinal_apoptosis0.88982073
75MP0002638_abnormal_pupillary_reflex0.87819674
76MP0001502_abnormal_circadian_rhythm0.86628344
77MP0004215_abnormal_myocardial_fiber0.86077473
78MP0003861_abnormal_nervous_system0.86026074
79MP0002796_impaired_skin_barrier0.84497347
80MP0006292_abnormal_olfactory_placode0.83412601
81MP0003119_abnormal_digestive_system0.82806348
82MP0008872_abnormal_physiological_respon0.80875900
83MP0001765_abnormal_ion_homeostasis0.79722484
84MP0001529_abnormal_vocalization0.79624618
85MP0001485_abnormal_pinna_reflex0.78838172
86MP0004142_abnormal_muscle_tone0.78801614
87MP0004147_increased_porphyrin_level0.76909571
88MP0003634_abnormal_glial_cell0.76773924
89MP0005187_abnormal_penis_morphology0.76459511
90MP0004484_altered_response_of0.76042704
91MP0004133_heterotaxia0.75866119
92MP0002102_abnormal_ear_morphology0.74894261
93MP0002837_dystrophic_cardiac_calcinosis0.74393803
94MP0002752_abnormal_somatic_nervous0.73783120
95MP0003938_abnormal_ear_development0.73380209
96MP0008874_decreased_physiological_sensi0.72937006
97MP0005379_endocrine/exocrine_gland_phen0.72816935
98MP0001177_atelectasis0.71234654
99MP0008789_abnormal_olfactory_epithelium0.70944573
100MP0002229_neurodegeneration0.69930381
101MP0010771_integument_phenotype0.69677303
102MP0003632_abnormal_nervous_system0.69406323
103MP0001944_abnormal_pancreas_morphology0.68938122
104MP0005248_abnormal_Harderian_gland0.66514440
105MP0005623_abnormal_meninges_morphology0.66122705
106MP0000604_amyloidosis0.65358097
107MP0005377_hearing/vestibular/ear_phenot0.65196680
108MP0003878_abnormal_ear_physiology0.65196680
109MP0003075_altered_response_to0.63138177
110MP0002254_reproductive_system_inflammat0.62806572
111MP0000920_abnormal_myelination0.62542827
112MP0004130_abnormal_muscle_cell0.62181129
113MP0001963_abnormal_hearing_physiology0.62100519
114MP0003890_abnormal_embryonic-extraembry0.61361282
115MP0005535_abnormal_body_temperature0.59562012
116MP0002090_abnormal_vision0.59537230
117MP0000026_abnormal_inner_ear0.59471905
118MP0000579_abnormal_nail_morphology0.59118291
119MP0004043_abnormal_pH_regulation0.57089341
120MP0002081_perinatal_lethality0.56892355
121MP0010769_abnormal_survival0.56848200
122MP0001346_abnormal_lacrimal_gland0.55360301
123MP0004742_abnormal_vestibular_system0.55290904
124MP0008875_abnormal_xenobiotic_pharmacok0.54696902
125MP0008770_decreased_survivor_rate0.54154364
126MP0004233_abnormal_muscle_weight0.54020361
127MP0003646_muscle_fatigue0.53634903
128MP0010768_mortality/aging0.52994461

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.92274999
2Focal motor seizures (HP:0011153)4.99711876
3Focal seizures (HP:0007359)4.77345093
4Epileptic encephalopathy (HP:0200134)4.65226798
5Visual hallucinations (HP:0002367)4.59550325
6Amyotrophic lateral sclerosis (HP:0007354)4.30653634
7Mutism (HP:0002300)4.28666696
8Increased circulating renin level (HP:0000848)3.96876052
9Supranuclear gaze palsy (HP:0000605)3.82195084
10Abnormality of the lower motor neuron (HP:0002366)3.80443299
11Papilledema (HP:0001085)3.73130446
12Ankle clonus (HP:0011448)3.65760245
13Decreased circulating renin level (HP:0003351)3.51142504
14Hepatoblastoma (HP:0002884)3.46574054
15Febrile seizures (HP:0002373)3.45556718
16Hyperventilation (HP:0002883)3.43005410
17Poor eye contact (HP:0000817)3.34865083
18Hyperkalemia (HP:0002153)3.29020747
19Broad-based gait (HP:0002136)3.24794866
20Abnormality of the corticospinal tract (HP:0002492)3.19936937
21Limb dystonia (HP:0002451)3.15738735
22Progressive cerebellar ataxia (HP:0002073)3.11829350
23Generalized tonic-clonic seizures (HP:0002069)3.11119098
24Excessive salivation (HP:0003781)3.10028342
25Drooling (HP:0002307)3.10028342
26Hyperactive renin-angiotensin system (HP:0000841)3.04670488
27Absence seizures (HP:0002121)3.03778200
28Impaired social interactions (HP:0000735)3.01750590
29Abnormal social behavior (HP:0012433)3.01750590
30Obstructive sleep apnea (HP:0002870)3.00211819
31Amblyopia (HP:0000646)3.00105734
32Atonic seizures (HP:0010819)2.98313965
33Dialeptic seizures (HP:0011146)2.97946226
34Urinary bladder sphincter dysfunction (HP:0002839)2.85679977
35Cerebral inclusion bodies (HP:0100314)2.85435029
36Neurofibrillary tangles (HP:0002185)2.84483865
37Torticollis (HP:0000473)2.84059998
38Depression (HP:0000716)2.81658883
39Hyperaldosteronism (HP:0000859)2.76562836
40Akinesia (HP:0002304)2.73675039
41Inappropriate behavior (HP:0000719)2.73478766
42Apathy (HP:0000741)2.71214929
43Genetic anticipation (HP:0003743)2.69766287
44Hemiparesis (HP:0001269)2.67591569
45Inability to walk (HP:0002540)2.66937073
46Polyphagia (HP:0002591)2.62518214
47Abnormal eating behavior (HP:0100738)2.60867131
48Abnormality of binocular vision (HP:0011514)2.60797087
49Diplopia (HP:0000651)2.60797087
50Syncope (HP:0001279)2.57290061
51Lower limb amyotrophy (HP:0007210)2.52584055
52Action tremor (HP:0002345)2.51853345
53Impaired vibration sensation in the lower limbs (HP:0002166)2.51347270
54Urinary urgency (HP:0000012)2.49699016
55Stereotypic behavior (HP:0000733)2.48837493
56Progressive inability to walk (HP:0002505)2.47761816
57Fetal akinesia sequence (HP:0001989)2.44199000
58Focal dystonia (HP:0004373)2.43063616
59Abnormality of renin-angiotensin system (HP:0000847)2.42490969
60Megalencephaly (HP:0001355)2.41154298
61Postural instability (HP:0002172)2.39075177
62Diminished motivation (HP:0000745)2.37801689
63Ankyloglossia (HP:0010296)2.37067377
64Dysdiadochokinesis (HP:0002075)2.36108888
65Diminished movement (HP:0002374)2.35930962
66Epileptiform EEG discharges (HP:0011182)2.30405558
67EEG with generalized epileptiform discharges (HP:0011198)2.30113706
68Anxiety (HP:0000739)2.29777682
69Hypsarrhythmia (HP:0002521)2.27031396
70Status epilepticus (HP:0002133)2.26166295
71Spastic gait (HP:0002064)2.25147060
72Bradykinesia (HP:0002067)2.22195922
73Craniofacial dystonia (HP:0012179)2.22162319
74Lower limb muscle weakness (HP:0007340)2.18280016
75Spastic tetraparesis (HP:0001285)2.17819522
76Intellectual disability, profound (HP:0002187)2.16778646
77Absent speech (HP:0001344)2.14710648
78Pheochromocytoma (HP:0002666)2.13305633
79Termporal pattern (HP:0011008)2.11851503
80Insidious onset (HP:0003587)2.11851503
81Astrocytoma (HP:0009592)2.10056079
82Abnormality of the astrocytes (HP:0100707)2.10056079
83Delusions (HP:0000746)2.09269694
84Tetraplegia (HP:0002445)2.06148787
85Dysmetria (HP:0001310)2.05933208
86Open mouth (HP:0000194)2.05482245
87Morphological abnormality of the pyramidal tract (HP:0002062)2.03420841
88Generalized myoclonic seizures (HP:0002123)2.03318482
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02646764
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.02646764
91Ventricular fibrillation (HP:0001663)2.02355180
92Cerebral hypomyelination (HP:0006808)2.01736567
93Intention tremor (HP:0002080)2.01235602
94Truncal ataxia (HP:0002078)2.00581953
95Generalized hypotonia (HP:0001290)1.98979656
96Atrophy/Degeneration involving motor neurons (HP:0007373)1.97873913
97Sleep apnea (HP:0010535)1.96741309
98Insomnia (HP:0100785)1.95893649
99Abnormality of potassium homeostasis (HP:0011042)1.95435695
100Abnormality of salivation (HP:0100755)1.94155280
101Gaze-evoked nystagmus (HP:0000640)1.93989033
102Muscular hypotonia of the trunk (HP:0008936)1.92079438
103Bilateral microphthalmos (HP:0007633)1.91950495
104Conjunctival hamartoma (HP:0100780)1.90167500
105Agitation (HP:0000713)1.89413487
106Pachygyria (HP:0001302)1.89230128
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89038763
108Abnormal EKG (HP:0003115)1.88952446
109Neuronal loss in central nervous system (HP:0002529)1.84454552
110Impaired smooth pursuit (HP:0007772)1.83926134
111Sudden death (HP:0001699)1.83027464
112Palmoplantar hyperkeratosis (HP:0000972)1.82134437
113Plantar hyperkeratosis (HP:0007556)1.81664212
114Widely spaced teeth (HP:0000687)1.81526641
115Neoplasm of the adrenal cortex (HP:0100641)1.79853342
116CNS hypomyelination (HP:0003429)1.79598922
117Congenital malformation of the right heart (HP:0011723)1.79470768
118Double outlet right ventricle (HP:0001719)1.79470768
119Clonus (HP:0002169)1.79137126
120Lissencephaly (HP:0001339)1.78522901
121Rapidly progressive (HP:0003678)1.78431379
122Intellectual disability, severe (HP:0010864)1.78311775
123Aqueductal stenosis (HP:0002410)1.77851709
124Bronchomalacia (HP:0002780)1.76176293
125Bundle branch block (HP:0011710)1.75480092
126Unilateral renal agenesis (HP:0000122)1.75445634
127Choreoathetosis (HP:0001266)1.75038221
128Adrenal overactivity (HP:0002717)1.73649568
129Hamartoma of the eye (HP:0010568)1.73589424
130Spastic tetraplegia (HP:0002510)1.72723891
131Palmar hyperkeratosis (HP:0010765)1.69684471
132Neuroendocrine neoplasm (HP:0100634)1.69542348
133Hyperthyroidism (HP:0000836)1.68355628
134Abnormality of chloride homeostasis (HP:0011422)1.67527135
135Nuclear cataract (HP:0100018)1.66001609
136Hypokinesia (HP:0002375)1.63886887
137Impaired vibratory sensation (HP:0002495)1.63050670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.58096691
2MAP3K94.41448986
3NTRK33.35463798
4EPHA43.30569732
5MINK12.60712406
6NTRK22.45227372
7MAP3K42.38790184
8DAPK22.38777403
9GRK52.17297290
10PHKG12.15504489
11PHKG22.15504489
12PAK62.07840615
13LATS22.06462627
14FRK2.01712044
15MAP2K71.99829785
16NTRK11.86153836
17KSR21.69501620
18MAP2K41.68730972
19PRKD31.66465544
20KSR11.61020875
21MAPK131.60274747
22CAMKK11.58972171
23SIK21.56086867
24TYRO31.54195474
25DYRK21.52231155
26CDK51.45808277
27PINK11.44940507
28TAOK11.42264134
29MARK21.34154955
30DAPK11.33187969
31OXSR11.30065354
32MAP3K21.17493276
33PRPF4B1.16108587
34MAP3K121.12970831
35TNIK1.12126346
36PLK21.11918411
37NME11.10200788
38ERBB31.08021245
39CASK1.07972011
40PRKCG1.06116861
41STK381.03459697
42WNK41.02824721
43PAK30.99432064
44* MAP2K60.98897564
45ALK0.95847295
46CSNK1G20.95714847
47TAOK20.94807343
48UHMK10.92848289
49DYRK1A0.92340484
50WNK30.91778588
51MAPK120.89564413
52STK110.86940838
53CDK180.85183571
54CDK150.84724523
55CDK140.79706753
56FGFR20.78445160
57STK390.77797746
58EPHA20.77635245
59CAMK10.76492073
60RET0.74467023
61CDK11A0.73725568
62BMPR1B0.73644688
63PKN10.73004034
64CAMK2A0.68812212
65TRIM280.66848066
66PRKCZ0.64404705
67SCYL20.63203272
68RPS6KA20.60681192
69LMTK20.60489374
70ADRBK20.60291448
71PRKCH0.59773397
72BCR0.59145861
73RIPK10.56839211
74GRK60.56708105
75MAPK70.55987071
76CAMK40.55867352
77CDK190.55489124
78CAMK2G0.55396566
79PRKG20.55009536
80MAP3K60.53589235
81SGK10.53122449
82MAP4K20.52871993
83CDK120.51426556
84NEK10.50700585
85CAMK1G0.46747564
86FYN0.46382536
87CCNB10.46202619
88FES0.46102457
89SGK4940.44978546
90SGK2230.44978546
91MAP3K70.44772299
92RAF10.44234039
93PNCK0.43150977
94PDK10.42114882
95RPS6KA30.41952678
96CAMK2D0.41555398
97RIPK40.40828008
98PRKCE0.40590703
99INSRR0.40462172
100MST1R0.40192338
101MST40.39716262
102ARAF0.39576658
103CSNK1A1L0.39515635
104SGK30.38784819
105PRKAA10.38657392
106PRKCI0.38001940
107EPHB20.37589490
108PRKCA0.36214798
109SGK20.35886267
110GRK70.35854302
111PDK40.35808108
112PDK30.35808108
113MAP2K10.35757691
114CAMKK20.34487704
115RPS6KB10.34155252
116DMPK0.33864098
117CSNK1G30.33289407
118CAMK2B0.33131987
119NEK60.32876731
120ROCK20.32433217
121BRSK10.31658614
122CSNK1A10.31521881
123LIMK10.31135097
124PDPK10.31036658
125MAPK100.30995965
126STK38L0.30368076
127EIF2AK20.30058555
128FER0.29948571
129CDC42BPA0.29906964
130DAPK30.27732153
131MAPK90.27419165
132CSNK1D0.27266761

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.01724719
2Synaptic vesicle cycle_Homo sapiens_hsa047213.00022565
3Olfactory transduction_Homo sapiens_hsa047402.67928123
4Circadian entrainment_Homo sapiens_hsa047132.57583702
5GABAergic synapse_Homo sapiens_hsa047272.52217440
6Long-term potentiation_Homo sapiens_hsa047202.44517392
7Glutamatergic synapse_Homo sapiens_hsa047242.38961649
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38865313
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30286417
10Morphine addiction_Homo sapiens_hsa050322.25895776
11Dopaminergic synapse_Homo sapiens_hsa047282.12735330
12Amphetamine addiction_Homo sapiens_hsa050312.09673148
13Salivary secretion_Homo sapiens_hsa049701.96191898
14Cholinergic synapse_Homo sapiens_hsa047251.91237426
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79076778
16Insulin secretion_Homo sapiens_hsa049111.76446591
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73456472
18Gastric acid secretion_Homo sapiens_hsa049711.72587293
19Renin secretion_Homo sapiens_hsa049241.69584227
20Oxytocin signaling pathway_Homo sapiens_hsa049211.69266007
21Vitamin B6 metabolism_Homo sapiens_hsa007501.62441505
22Long-term depression_Homo sapiens_hsa047301.61889355
23Serotonergic synapse_Homo sapiens_hsa047261.61411362
24* Axon guidance_Homo sapiens_hsa043601.58264179
25Cocaine addiction_Homo sapiens_hsa050301.54816679
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53149113
27GnRH signaling pathway_Homo sapiens_hsa049121.51559697
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51000435
29Gap junction_Homo sapiens_hsa045401.46945330
30Taste transduction_Homo sapiens_hsa047421.45676820
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.45269949
32Calcium signaling pathway_Homo sapiens_hsa040201.40451018
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36163395
34Glioma_Homo sapiens_hsa052141.29801548
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.29323488
36Estrogen signaling pathway_Homo sapiens_hsa049151.29105825
37cAMP signaling pathway_Homo sapiens_hsa040241.25210953
38Type II diabetes mellitus_Homo sapiens_hsa049301.22002349
39Melanogenesis_Homo sapiens_hsa049161.17616851
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14871653
41* ErbB signaling pathway_Homo sapiens_hsa040121.09766313
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09554738
43Butanoate metabolism_Homo sapiens_hsa006501.08304289
44Circadian rhythm_Homo sapiens_hsa047101.04733590
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.03832994
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03696145
47Endometrial cancer_Homo sapiens_hsa052131.01510214
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01365928
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.96837035
50Oxidative phosphorylation_Homo sapiens_hsa001900.96505216
51Collecting duct acid secretion_Homo sapiens_hsa049660.93906672
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93056855
53Dilated cardiomyopathy_Homo sapiens_hsa054140.92055133
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.90080988
55mTOR signaling pathway_Homo sapiens_hsa041500.89780009
56VEGF signaling pathway_Homo sapiens_hsa043700.89309463
57Choline metabolism in cancer_Homo sapiens_hsa052310.88770621
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.88477774
59Oocyte meiosis_Homo sapiens_hsa041140.86996497
60Alzheimers disease_Homo sapiens_hsa050100.86178972
61Dorso-ventral axis formation_Homo sapiens_hsa043200.85756244
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85495097
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84247858
64Cardiac muscle contraction_Homo sapiens_hsa042600.82801540
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79642223
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78453446
67Ether lipid metabolism_Homo sapiens_hsa005650.76599115
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76215480
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75623993
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75575735
71MAPK signaling pathway_Homo sapiens_hsa040100.74920032
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.74365361
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73523325
74Arginine biosynthesis_Homo sapiens_hsa002200.72014394
75Colorectal cancer_Homo sapiens_hsa052100.71981250
76Rap1 signaling pathway_Homo sapiens_hsa040150.70071120
77Linoleic acid metabolism_Homo sapiens_hsa005910.70026600
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69977217
79* Ras signaling pathway_Homo sapiens_hsa040140.69279362
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67853261
81Non-small cell lung cancer_Homo sapiens_hsa052230.63906668
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62681629
83Wnt signaling pathway_Homo sapiens_hsa043100.62298777
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62038402
85Vibrio cholerae infection_Homo sapiens_hsa051100.61619258
86Insulin signaling pathway_Homo sapiens_hsa049100.59717597
87Pancreatic secretion_Homo sapiens_hsa049720.59286764
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58233056
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57725020
90Ovarian steroidogenesis_Homo sapiens_hsa049130.56805406
91Endocytosis_Homo sapiens_hsa041440.56757994
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55437415
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53678572
94Thyroid hormone synthesis_Homo sapiens_hsa049180.53525456
95Glucagon signaling pathway_Homo sapiens_hsa049220.51825918
96Parkinsons disease_Homo sapiens_hsa050120.50935754
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50298989
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49670078
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49612332
100* Renal cell carcinoma_Homo sapiens_hsa052110.49025672
101Folate biosynthesis_Homo sapiens_hsa007900.48686706
102Alcoholism_Homo sapiens_hsa050340.48375219
103Phototransduction_Homo sapiens_hsa047440.48180259
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46365162
105Hippo signaling pathway_Homo sapiens_hsa043900.45428636
106Nitrogen metabolism_Homo sapiens_hsa009100.44725814
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44457200
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44359426
109Tight junction_Homo sapiens_hsa045300.44073116
110beta-Alanine metabolism_Homo sapiens_hsa004100.44028006
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43986287
112Inositol phosphate metabolism_Homo sapiens_hsa005620.43936995
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.43043659
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42768045
115Mineral absorption_Homo sapiens_hsa049780.40552421
116Prolactin signaling pathway_Homo sapiens_hsa049170.40084051
117ABC transporters_Homo sapiens_hsa020100.40018207
118Hedgehog signaling pathway_Homo sapiens_hsa043400.39287344
119Prion diseases_Homo sapiens_hsa050200.38234783
120* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37213027
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.36774302
122Bile secretion_Homo sapiens_hsa049760.35913513
123Chemokine signaling pathway_Homo sapiens_hsa040620.34930912
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32706957
125Fatty acid biosynthesis_Homo sapiens_hsa000610.30233714
126Protein export_Homo sapiens_hsa030600.30117429
127Arginine and proline metabolism_Homo sapiens_hsa003300.28460500
128Histidine metabolism_Homo sapiens_hsa003400.27064339

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