PALB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)4.75586871
2DNA strand elongation involved in DNA replication (GO:0006271)4.71284759
3DNA strand elongation (GO:0022616)4.50927118
4telomere maintenance via recombination (GO:0000722)4.47123929
5DNA replication initiation (GO:0006270)4.46825332
6kinetochore organization (GO:0051383)4.42662847
7mitotic recombination (GO:0006312)4.41401236
8CENP-A containing nucleosome assembly (GO:0034080)4.28359950
9pore complex assembly (GO:0046931)4.28041068
10DNA replication checkpoint (GO:0000076)4.27633617
11chromatin remodeling at centromere (GO:0031055)4.25667578
12DNA replication-dependent nucleosome organization (GO:0034723)4.19996092
13DNA replication-dependent nucleosome assembly (GO:0006335)4.19996092
14kinetochore assembly (GO:0051382)4.13482045
15non-recombinational repair (GO:0000726)4.09457380
16double-strand break repair via nonhomologous end joining (GO:0006303)4.09457380
17mitotic metaphase plate congression (GO:0007080)4.02667550
18protein localization to kinetochore (GO:0034501)3.88858333
19meiotic chromosome segregation (GO:0045132)3.88689181
20DNA replication-independent nucleosome assembly (GO:0006336)3.88227820
21DNA replication-independent nucleosome organization (GO:0034724)3.88227820
22DNA double-strand break processing (GO:0000729)3.88036287
23DNA unwinding involved in DNA replication (GO:0006268)3.86068005
24telomere maintenance via telomere lengthening (GO:0010833)3.84905588
25establishment of integrated proviral latency (GO:0075713)3.84720874
26protein K6-linked ubiquitination (GO:0085020)3.80541983
27positive regulation of chromosome segregation (GO:0051984)3.78584712
28somatic hypermutation of immunoglobulin genes (GO:0016446)3.77960153
29somatic diversification of immune receptors via somatic mutation (GO:0002566)3.77960153
30microtubule depolymerization (GO:0007019)3.77568900
31metaphase plate congression (GO:0051310)3.76626760
32nuclear envelope disassembly (GO:0051081)3.74015443
33membrane disassembly (GO:0030397)3.74015443
34mismatch repair (GO:0006298)3.73717164
35regulation of double-strand break repair via homologous recombination (GO:0010569)3.73100317
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.70687518
37attachment of spindle microtubules to kinetochore (GO:0008608)3.63468036
38establishment of chromosome localization (GO:0051303)3.62929238
39ribosome assembly (GO:0042255)3.61353988
40nucleotide-excision repair, DNA gap filling (GO:0006297)3.60546587
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55535470
42positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.51108467
43positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.51108467
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.51108467
45protein localization to chromosome, centromeric region (GO:0071459)3.50146582
46histone exchange (GO:0043486)3.44002625
47regulation of mitotic spindle checkpoint (GO:1903504)3.43032360
48regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43032360
49regulation of sister chromatid cohesion (GO:0007063)3.41918353
50regulation of DNA endoreduplication (GO:0032875)3.38496000
51mitotic sister chromatid cohesion (GO:0007064)3.35449839
52positive regulation of histone H3-K4 methylation (GO:0051571)3.34089621
53folic acid-containing compound biosynthetic process (GO:0009396)3.31941101
54mitotic sister chromatid segregation (GO:0000070)3.31705716
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.30454078
56regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.26792369
57nuclear pore organization (GO:0006999)3.25027612
58mitotic G2/M transition checkpoint (GO:0044818)3.24663499
59telomere maintenance (GO:0000723)3.23995026
60heterochromatin organization (GO:0070828)3.23648096
61mitotic chromosome condensation (GO:0007076)3.23131161
62telomere organization (GO:0032200)3.22285553
63purine nucleobase biosynthetic process (GO:0009113)3.20304346
64spindle checkpoint (GO:0031577)3.20197718
65IMP biosynthetic process (GO:0006188)3.17580961
66nuclear pore complex assembly (GO:0051292)3.15452381
67regulation of helicase activity (GO:0051095)3.14852385
68negative regulation of DNA-dependent DNA replication (GO:2000104)3.14719790
69spindle assembly checkpoint (GO:0071173)3.14476930
70regulation of spindle checkpoint (GO:0090231)3.13433801
71rRNA methylation (GO:0031167)3.12349131
72intra-S DNA damage checkpoint (GO:0031573)3.11542585
73regulation of centrosome duplication (GO:0010824)3.10037860
74regulation of translational fidelity (GO:0006450)3.09967678
75ribosomal small subunit assembly (GO:0000028)3.08449685
76DNA synthesis involved in DNA repair (GO:0000731)3.07278975
77negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06891738
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06891738
79negative regulation of sister chromatid segregation (GO:0033046)3.06891738
80negative regulation of mitotic sister chromatid separation (GO:2000816)3.06891738
81negative regulation of chromosome segregation (GO:0051985)3.06201074
82chromatin assembly or disassembly (GO:0006333)3.05807045
83sister chromatid segregation (GO:0000819)3.03152910
84mitotic spindle assembly checkpoint (GO:0007094)3.02545855
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.02158927
86regulation of mitotic metaphase/anaphase transition (GO:0030071)3.01623127
87transcription-coupled nucleotide-excision repair (GO:0006283)3.00974717
88mitotic nuclear envelope disassembly (GO:0007077)3.00617211
89response to X-ray (GO:0010165)2.98829993
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.98085696
91mitotic spindle checkpoint (GO:0071174)2.97380670
92replication fork processing (GO:0031297)2.97058232
93maturation of 5.8S rRNA (GO:0000460)2.96167299
94chromosome segregation (GO:0007059)2.96084510
95DNA duplex unwinding (GO:0032508)2.95125228
96DNA geometric change (GO:0032392)2.95105890
97DNA replication (GO:0006260)2.93532326
98DNA strand renaturation (GO:0000733)2.92209315
99DNA catabolic process, exonucleolytic (GO:0000738)2.91387960
100regulation of mitotic sister chromatid separation (GO:0010965)2.88758339
101regulation of mitotic sister chromatid segregation (GO:0033047)2.88758339
102regulation of sister chromatid segregation (GO:0033045)2.88758339
103regulation of chromosome segregation (GO:0051983)2.83332500
104postreplication repair (GO:0006301)2.81560979
105maturation of SSU-rRNA (GO:0030490)2.81489224
106regulation of double-strand break repair (GO:2000779)2.81108876
107nucleobase biosynthetic process (GO:0046112)2.81053864
108deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.81008132
109regulation of histone H3-K9 methylation (GO:0051570)2.79241002
110regulation of centrosome cycle (GO:0046605)2.79039464
111B cell mediated immunity (GO:0019724)2.75878038
112* recombinational repair (GO:0000725)2.75447022
113DNA ligation (GO:0006266)2.75267559
114ATP-dependent chromatin remodeling (GO:0043044)2.75066414
115DNA topological change (GO:0006265)2.74778803
116regulation of spindle organization (GO:0090224)2.74325894
117mature B cell differentiation involved in immune response (GO:0002313)2.74224473
118somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.73657963
119somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.73657963
120isotype switching (GO:0045190)2.73657963
121rRNA modification (GO:0000154)2.72482000
122* DNA recombination (GO:0006310)2.71654068
123regulation of centriole replication (GO:0046599)2.71198878
124IMP metabolic process (GO:0046040)2.70260634
125protein localization to chromosome (GO:0034502)2.70048979
126somatic recombination of immunoglobulin gene segments (GO:0016447)2.69853494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.99846351
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.67330934
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.75775007
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.34442058
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92801421
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51307499
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.46166701
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35319876
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.34027844
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29408938
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20872895
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19481057
13MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.19096361
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11306393
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10470900
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.06646996
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.03352203
18E2F7_22180533_ChIP-Seq_HELA_Human11.9665231
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.96962433
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94907600
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94465304
22ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92699228
23VDR_23849224_ChIP-Seq_CD4+_Human1.92416069
24* FOXP3_21729870_ChIP-Seq_TREG_Human1.89328678
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89305801
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.88324866
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.87814233
28* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85539168
29AR_21909140_ChIP-Seq_LNCAP_Human1.84634221
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80191617
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79964861
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.76257728
33ELK1_19687146_ChIP-ChIP_HELA_Human1.71104525
34XRN2_22483619_ChIP-Seq_HELA_Human1.67158673
35* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64136966
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62620791
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60406208
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59895564
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59476561
40PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.58750722
41* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56609536
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56057650
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55577003
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53563457
45TTF2_22483619_ChIP-Seq_HELA_Human1.52252946
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51079290
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47161489
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41587780
49DCP1A_22483619_ChIP-Seq_HELA_Human1.41194692
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39308298
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38198795
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.32464463
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.31404206
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31269659
55CIITA_25753668_ChIP-Seq_RAJI_Human1.31078514
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29637488
57* GABP_19822575_ChIP-Seq_HepG2_Human1.29521689
58* SRF_21415370_ChIP-Seq_HL-1_Mouse1.29156702
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28768893
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28625384
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28568092
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26662323
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24868444
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22173572
65MYC_18940864_ChIP-ChIP_HL60_Human1.20267156
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19736910
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19192407
68SPI1_23547873_ChIP-Seq_NB4_Human1.18438558
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17224720
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.09752011
71KDM5A_27292631_Chip-Seq_BREAST_Human1.08633333
72SCL_19346495_ChIP-Seq_HPC-7_Human1.07672574
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07383018
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.06133743
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05227693
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04754922
77NANOG_16153702_ChIP-ChIP_HESCs_Human1.03212405
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02721576
79IRF1_19129219_ChIP-ChIP_H3396_Human1.02628349
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02317528
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.01835869
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.00369745
83MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00357425
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99492194
85EWS_26573619_Chip-Seq_HEK293_Human0.96978012
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96941110
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96394117
88ZNF274_21170338_ChIP-Seq_K562_Hela0.95719116
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95305399
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94763841
91PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93903824
92* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93814193
93* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91237668
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91018243
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88260299
96DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83995559
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83982833
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83277219
99TFEB_21752829_ChIP-Seq_HELA_Human0.82644685
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81946552
101FUS_26573619_Chip-Seq_HEK293_Human0.79427732
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.78624232
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.77917872
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77611995
105ELK1_22589737_ChIP-Seq_MCF10A_Human0.77059514
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.76744352
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75398173
108MYC_22102868_ChIP-Seq_BL_Human0.74247271
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.73411021
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.73311542
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.73311542
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.73311542
113CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72850417
114VDR_21846776_ChIP-Seq_THP-1_Human0.72814761
115KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71001444
116MYB_21317192_ChIP-Seq_ERMYB_Mouse0.70839132
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.70488148
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70131745
119BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69210358
120PCGF2_27294783_Chip-Seq_ESCs_Mouse0.68410914
121CHD1_26751641_Chip-Seq_LNCaP_Human0.67085833
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66992020
123IRF8_22096565_ChIP-ChIP_GC-B_Human0.66025927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.91128837
2MP0010094_abnormal_chromosome_stability4.79291235
3MP0003111_abnormal_nucleus_morphology4.50843953
4MP0008057_abnormal_DNA_replication4.23595938
5MP0008058_abnormal_DNA_repair3.80244901
6MP0003077_abnormal_cell_cycle3.55069604
7MP0004957_abnormal_blastocyst_morpholog3.21583336
8MP0002396_abnormal_hematopoietic_system3.19581386
9MP0008877_abnormal_DNA_methylation2.86779397
10MP0008007_abnormal_cellular_replicative2.79027743
11MP0006292_abnormal_olfactory_placode2.45509045
12MP0003786_premature_aging2.23910057
13* MP0008932_abnormal_embryonic_tissue2.16278773
14* MP0003890_abnormal_embryonic-extraembry2.13917372
15MP0010307_abnormal_tumor_latency2.12071575
16MP0001835_abnormal_antigen_presentation1.83311899
17MP0009672_abnormal_birth_weight1.76795137
18MP0000350_abnormal_cell_proliferation1.70988467
19MP0003763_abnormal_thymus_physiology1.65247315
20MP0000490_abnormal_crypts_of1.64214301
21MP0010352_gastrointestinal_tract_polyps1.63539941
22MP0003718_maternal_effect1.51166682
23MP0002210_abnormal_sex_determination1.49729232
24MP0003136_yellow_coat_color1.47575625
25MP0006035_abnormal_mitochondrial_morpho1.41867377
26MP0004808_abnormal_hematopoietic_stem1.40297026
27MP0001730_embryonic_growth_arrest1.39134271
28MP0002019_abnormal_tumor_incidence1.39081950
29MP0001545_abnormal_hematopoietic_system1.38954346
30MP0005397_hematopoietic_system_phenotyp1.38954346
31MP0003787_abnormal_imprinting1.36590335
32MP0005174_abnormal_tail_pigmentation1.35901148
33MP0002398_abnormal_bone_marrow1.34372669
34MP0000313_abnormal_cell_death1.32999424
35MP0001188_hyperpigmentation1.27991181
36MP0002006_tumorigenesis1.27028864
37MP0009333_abnormal_splenocyte_physiolog1.24186023
38MP0000358_abnormal_cell_content/1.22931998
39* MP0003937_abnormal_limbs/digits/tail_de1.22523894
40MP0005671_abnormal_response_to1.22450594
41MP0003121_genomic_imprinting1.21589523
42MP0000689_abnormal_spleen_morphology1.20561286
43MP0001145_abnormal_male_reproductive1.20480995
44MP0001119_abnormal_female_reproductive1.20258428
45MP0002102_abnormal_ear_morphology1.17718861
46MP0001800_abnormal_humoral_immune1.16860639
47MP0002722_abnormal_immune_system1.16539709
48MP0003315_abnormal_perineum_morphology1.15654348
49MP0002095_abnormal_skin_pigmentation1.14930700
50MP0002009_preneoplasia1.13904733
51MP0000703_abnormal_thymus_morphology1.13403038
52MP0002166_altered_tumor_susceptibility1.12734808
53MP0005075_abnormal_melanosome_morpholog1.11593244
54MP0002160_abnormal_reproductive_system1.11558171
55MP0000653_abnormal_sex_gland1.11354915
56MP0009785_altered_susceptibility_to1.08858352
57MP0001929_abnormal_gametogenesis1.08726622
58MP0002132_abnormal_respiratory_system1.08516038
59* MP0005380_embryogenesis_phenotype1.07869874
60* MP0001672_abnormal_embryogenesis/_devel1.07869874
61MP0003806_abnormal_nucleotide_metabolis1.07368510
62MP0002452_abnormal_antigen_presenting1.06930588
63MP0002420_abnormal_adaptive_immunity1.05923687
64MP0002697_abnormal_eye_size1.05573226
65MP0001819_abnormal_immune_cell1.05332788
66MP0010234_abnormal_vibrissa_follicle1.05245808
67MP0009703_decreased_birth_body1.04881560
68MP0002111_abnormal_tail_morphology1.03821547
69* MP0001697_abnormal_embryo_size1.03265583
70MP0001286_abnormal_eye_development1.02669560
71MP0000716_abnormal_immune_system1.02483208
72MP0002429_abnormal_blood_cell1.02106636
73MP0005395_other_phenotype1.01348814
74MP0004133_heterotaxia1.00033781
75MP0001529_abnormal_vocalization0.99217313
76MP0005394_taste/olfaction_phenotype0.99148883
77MP0005499_abnormal_olfactory_system0.99148883
78MP0009697_abnormal_copulation0.98405518
79MP0005408_hypopigmentation0.97768695
80* MP0002085_abnormal_embryonic_tissue0.97471503
81MP0003221_abnormal_cardiomyocyte_apopto0.96442701
82MP0005389_reproductive_system_phenotype0.96090906
83MP0002723_abnormal_immune_serum0.95309468
84MP0002938_white_spotting0.94871626
85MP0002796_impaired_skin_barrier0.93783789
86MP0003699_abnormal_female_reproductive0.93429575
87MP0002419_abnormal_innate_immunity0.93313842
88MP0008995_early_reproductive_senescence0.92213915
89MP0000858_altered_metastatic_potential0.92113166
90MP0000566_synostosis0.91409430
91* MP0002080_prenatal_lethality0.90368592
92MP0003984_embryonic_growth_retardation0.90281872
93MP0000015_abnormal_ear_pigmentation0.90198059
94MP0002277_abnormal_respiratory_mucosa0.90138655
95MP0005384_cellular_phenotype0.88756314
96MP0003950_abnormal_plasma_membrane0.88344058
97MP0003567_abnormal_fetal_cardiomyocyte0.88049063
98MP0005025_abnormal_response_to0.87893491
99MP0005501_abnormal_skin_physiology0.85645218
100MP0002088_abnormal_embryonic_growth/wei0.85592090
101MP0002233_abnormal_nose_morphology0.84891476
102MP0002075_abnormal_coat/hair_pigmentati0.84848859
103MP0004147_increased_porphyrin_level0.84724449
104MP0000428_abnormal_craniofacial_morphol0.84343691
105* MP0002086_abnormal_extraembryonic_tissu0.83732535
106MP0002877_abnormal_melanocyte_morpholog0.83403907
107MP0001186_pigmentation_phenotype0.82836059
108MP0001919_abnormal_reproductive_system0.82539731
109MP0003123_paternal_imprinting0.82068468
110MP0001915_intracranial_hemorrhage0.81664698
111MP0005000_abnormal_immune_tolerance0.81650699
112MP0002405_respiratory_system_inflammati0.81404509
113MP0001661_extended_life_span0.81216138
114MP0003941_abnormal_skin_development0.78821574
115MP0005409_darkened_coat_color0.78124279
116MP0002092_abnormal_eye_morphology0.77399117
117MP0000579_abnormal_nail_morphology0.76635517
118MP0001853_heart_inflammation0.75450580
119MP0002148_abnormal_hypersensitivity_rea0.74336105
120MP0003656_abnormal_erythrocyte_physiolo0.73571362
121* MP0002084_abnormal_developmental_patter0.72646915
122MP0001293_anophthalmia0.72351475
123MP0000372_irregular_coat_pigmentation0.72261281
124MP0000685_abnormal_immune_system0.72250395
125MP0004185_abnormal_adipocyte_glucose0.71822459
126MP0005621_abnormal_cell_physiology0.71740474
127MP0003436_decreased_susceptibility_to0.71384460
128MP0004197_abnormal_fetal_growth/weight/0.69402314
129MP0003448_altered_tumor_morphology0.69342978
130MP0008789_abnormal_olfactory_epithelium0.67880966
131MP0005076_abnormal_cell_differentiation0.67730185
132MP0004264_abnormal_extraembryonic_tissu0.65900085
133MP0002161_abnormal_fertility/fecundity0.65507667
134MP0004233_abnormal_muscle_weight0.65140618
135MP0002751_abnormal_autonomic_nervous0.63835616
136MP0003119_abnormal_digestive_system0.63573376
137MP0003755_abnormal_palate_morphology0.62785166
138MP0000762_abnormal_tongue_morphology0.62771283
139MP0000465_gastrointestinal_hemorrhage0.62651312
140MP0006054_spinal_hemorrhage0.57671907
141MP0000432_abnormal_head_morphology0.57145288
142MP0006036_abnormal_mitochondrial_physio0.56875663
143MP0006072_abnormal_retinal_apoptosis0.56437894
144MP0003935_abnormal_craniofacial_develop0.56051158
145MP0000647_abnormal_sebaceous_gland0.53449185
146MP0003698_abnormal_male_reproductive0.53417897

Predicted human phenotypes

RankGene SetZ-score
1* Chromosomal breakage induced by crosslinking agents (HP:0003221)6.43095858
2* Chromsome breakage (HP:0040012)6.32401024
3* Abnormality of chromosome stability (HP:0003220)4.28644448
4Birth length less than 3rd percentile (HP:0003561)4.18505243
5Reticulocytopenia (HP:0001896)4.17883256
6Ectopic kidney (HP:0000086)4.00817049
7Duplicated collecting system (HP:0000081)3.77374104
8* Abnormality of the preputium (HP:0100587)3.73538200
9* Meckel diverticulum (HP:0002245)3.72120556
10* Aplasia/Hypoplasia of the uvula (HP:0010293)3.70391720
11* Abnormality of the ileum (HP:0001549)3.62729556
12Abnormality of DNA repair (HP:0003254)3.41783009
13Abnormality of the renal collecting system (HP:0004742)3.39430922
14Agnosia (HP:0010524)3.35681707
15* Medulloblastoma (HP:0002885)3.24555387
16* Duodenal stenosis (HP:0100867)3.05851840
17* Small intestinal stenosis (HP:0012848)3.05851840
18* Clubbing of toes (HP:0100760)3.05778726
19Absent thumb (HP:0009777)3.04289031
20Multiple enchondromatosis (HP:0005701)2.98947784
21* Myelodysplasia (HP:0002863)2.98654815
22Prostate neoplasm (HP:0100787)2.95307118
23Colon cancer (HP:0003003)2.93817566
24Patellar aplasia (HP:0006443)2.89479563
25Abnormal lung lobation (HP:0002101)2.86784767
26Breast hypoplasia (HP:0003187)2.75742820
27Increased nuchal translucency (HP:0010880)2.72285411
28Supernumerary spleens (HP:0009799)2.71385107
29Aplasia/Hypoplasia of the patella (HP:0006498)2.66500570
30* Bone marrow hypocellularity (HP:0005528)2.66345343
31Impulsivity (HP:0100710)2.66023232
32Ependymoma (HP:0002888)2.61548694
33Facial cleft (HP:0002006)2.57222533
34* Nephroblastoma (Wilms tumor) (HP:0002667)2.52793238
35Papillary thyroid carcinoma (HP:0002895)2.52292019
36Asymmetry of the thorax (HP:0001555)2.51084941
37* Abnormality of the duodenum (HP:0002246)2.46498830
38* Abnormality of the carotid arteries (HP:0005344)2.46031231
39* Sloping forehead (HP:0000340)2.42059357
40* Embryonal neoplasm (HP:0002898)2.41553970
41Asplenia (HP:0001746)2.35938682
42Amaurosis fugax (HP:0100576)2.34302788
43Oral leukoplakia (HP:0002745)2.33404261
44* Embryonal renal neoplasm (HP:0011794)2.32685670
45Rhabdomyosarcoma (HP:0002859)2.31197829
46Absent radius (HP:0003974)2.30355910
47Abnormal number of erythroid precursors (HP:0012131)2.29600643
48Poikiloderma (HP:0001029)2.29326403
49Volvulus (HP:0002580)2.26801296
50* Short thumb (HP:0009778)2.26336323
51Abnormality of cells of the erythroid lineage (HP:0012130)2.25680579
52* Aplastic anemia (HP:0001915)2.24930579
53Abnormality of the prostate (HP:0008775)2.24776622
54Abnormality of pyrimidine metabolism (HP:0004353)2.23529868
55Progressive external ophthalmoplegia (HP:0000590)2.22378920
56Abnormal number of incisors (HP:0011064)2.21942320
57* Triphalangeal thumb (HP:0001199)2.21541307
58Type I transferrin isoform profile (HP:0003642)2.19606787
59Aplasia/Hypoplasia of the spleen (HP:0010451)2.17208804
60Pancreatic islet-cell hyperplasia (HP:0004510)2.17075054
61Sensory axonal neuropathy (HP:0003390)2.16459232
62Cleft eyelid (HP:0000625)2.16033385
63Rough bone trabeculation (HP:0100670)2.15422783
64Lymphoma (HP:0002665)2.13613096
65Aplasia involving forearm bones (HP:0009822)2.12620619
66Absent forearm bone (HP:0003953)2.12620619
67Overlapping toe (HP:0001845)2.09705389
68IgM deficiency (HP:0002850)2.09601641
6911 pairs of ribs (HP:0000878)2.08042389
70Acute myeloid leukemia (HP:0004808)2.02875290
71Acute lymphatic leukemia (HP:0006721)2.02703139
72Horseshoe kidney (HP:0000085)2.01241307
73Aplasia/Hypoplasia of the sternum (HP:0006714)2.00369235
74* Tracheoesophageal fistula (HP:0002575)1.99665393
75Abnormality of the labia minora (HP:0012880)1.99176780
76Abnormality of the fingertips (HP:0001211)1.97871272
77Spastic paraparesis (HP:0002313)1.97836495
78Duplication of thumb phalanx (HP:0009942)1.96475651
79Ovarian neoplasm (HP:0100615)1.95988372
80Premature graying of hair (HP:0002216)1.95100284
81Clitoromegaly (HP:0000057)1.93822493
82Abnormality of glycolysis (HP:0004366)1.93401204
83Increased serum pyruvate (HP:0003542)1.92771499
84Pallor (HP:0000980)1.92461190
85Selective tooth agenesis (HP:0001592)1.92276984
86Optic nerve coloboma (HP:0000588)1.91042539
87* Choanal atresia (HP:0000453)1.89771889
88Carpal bone hypoplasia (HP:0001498)1.89700398
89Broad alveolar ridges (HP:0000187)1.88610612
90Diastasis recti (HP:0001540)1.88265275
91Hyperglycinemia (HP:0002154)1.88022516
92Abnormal spermatogenesis (HP:0008669)1.87319381
93Hypoplasia of the pons (HP:0012110)1.84817651
94Thyroid carcinoma (HP:0002890)1.84810349
95Glioma (HP:0009733)1.83155586
96Obstructive lung disease (HP:0006536)1.83031508
97Chronic obstructive pulmonary disease (HP:0006510)1.83031508
98Abnormality of the pons (HP:0007361)1.81552927
99Anal stenosis (HP:0002025)1.81033265
100Neoplasm of the pancreas (HP:0002894)1.79838230
101Fibular aplasia (HP:0002990)1.78699657
102* Cafe-au-lait spot (HP:0000957)1.78320077
103Recurrent abscess formation (HP:0002722)1.78151125
104Abnormality of cochlea (HP:0000375)1.76267170
105Abdominal situs inversus (HP:0003363)1.76010121
106Abnormality of abdominal situs (HP:0011620)1.76010121
107Increased hepatocellular lipid droplets (HP:0006565)1.74881780
108* Arteriovenous malformation (HP:0100026)1.74617734
109High anterior hairline (HP:0009890)1.74542224
110IgG deficiency (HP:0004315)1.74013940
111Proximal placement of thumb (HP:0009623)1.73952684
112Capillary hemangiomas (HP:0005306)1.73531603
113* Oligohydramnios (HP:0001562)1.73224246
114Squamous cell carcinoma (HP:0002860)1.73087258
115Biliary tract neoplasm (HP:0100574)1.71930863
116Abnormality of chromosome segregation (HP:0002916)1.71768883
117Mediastinal lymphadenopathy (HP:0100721)1.69430387
118Progressive muscle weakness (HP:0003323)1.69331353
119Neoplasm of the oral cavity (HP:0100649)1.69198787
120Abnormal foot bone ossification (HP:0010675)1.69118121
121* Pancytopenia (HP:0001876)1.69036759
122Premature ovarian failure (HP:0008209)1.68621104
123Neoplasm of the colon (HP:0100273)1.68447484
124Acanthocytosis (HP:0001927)1.68045231
125Malignant gastrointestinal tract tumors (HP:0006749)1.66835149
126Gastrointestinal carcinoma (HP:0002672)1.66835149
127Deviation of the thumb (HP:0009603)1.65397569
128Anomalous pulmonary venous return (HP:0010772)1.65385761
129Lipid accumulation in hepatocytes (HP:0006561)1.65096754
130Absent eyebrow (HP:0002223)1.65047531
131Type 2 muscle fiber atrophy (HP:0003554)1.64660904
132Microvesicular hepatic steatosis (HP:0001414)1.64543999
133Cortical dysplasia (HP:0002539)1.64476187
134Septate vagina (HP:0001153)1.64343825
135Microtia (HP:0008551)1.64186643
136Pulmonary fibrosis (HP:0002206)1.63767737
137Abnormality of the astrocytes (HP:0100707)1.63581403
138Astrocytoma (HP:0009592)1.63581403
139Secondary amenorrhea (HP:0000869)1.63487694
140Abnormality of the alveolar ridges (HP:0006477)1.62720616
141Stomach cancer (HP:0012126)1.62635848
142Progressive inability to walk (HP:0002505)1.62182054
143Abnormal trabecular bone morphology (HP:0100671)1.61653913
144Cellular immunodeficiency (HP:0005374)1.60550705
145Hepatoblastoma (HP:0002884)1.60340448
146* Leukopenia (HP:0001882)1.59938975
147Facial hemangioma (HP:0000329)1.59755813
148Fibular hypoplasia (HP:0003038)1.59008557
149Neoplasm of striated muscle (HP:0009728)1.58591660
150Abnormality of the heme biosynthetic pathway (HP:0010472)1.57708274
151Abnormality of the intervertebral disk (HP:0005108)1.57412672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.22507593
2WEE13.79645604
3BUB12.93709064
4SRPK12.69661983
5PLK42.68411371
6TTK2.58691497
7NEK22.39899499
8BRSK22.38813518
9MKNK22.24180454
10MKNK12.20438090
11ZAK2.12322694
12STK38L2.11727359
13ATR2.02931824
14STK162.00054206
15PLK11.97258678
16CDK71.86776898
17VRK11.86355584
18ACVR1B1.83070092
19LATS11.83045624
20IRAK41.79966090
21EIF2AK11.76713456
22MST41.73610810
23EIF2AK31.66648035
24CHEK21.61592665
25CLK11.57650976
26NME21.54834529
27AURKB1.53999575
28BRSK11.53889432
29CDK121.48205142
30SCYL21.47461361
31STK41.47366671
32TLK11.43254688
33IRAK31.41315686
34CDK41.36780527
35PLK31.35176579
36TXK1.32595549
37TSSK61.31293273
38TRIM281.27406694
39EIF2AK21.27179191
40MAP3K141.26732948
41CCNB11.26453953
42TEC1.25978214
43TAF11.25358119
44KIT1.24198505
45VRK21.23109204
46CHEK11.21796487
47BTK1.20000711
48PIK3CG1.14743273
49YES11.11910190
50RPS6KA41.11648601
51ATM1.10393960
52PASK1.06581328
53STK241.04302317
54STK101.03679903
55BMPR1B1.03379964
56DYRK31.02563606
57AURKA1.00693603
58MAP3K80.98398112
59MAP4K10.97811816
60BRD40.95810963
61PIM10.93623560
62BCR0.92638032
63NME10.90891278
64MELK0.88252148
65TNIK0.86475880
66RPS6KB20.84934152
67MAP3K90.84759964
68NEK10.84007771
69ERBB40.83630453
70MAP3K60.83466168
71NUAK10.83277974
72TNK20.82605509
73TAOK30.79131152
74CDK20.77694738
75WNK30.76840371
76BRAF0.74788042
77PBK0.74689240
78CDK30.72467988
79CSNK2A10.68934274
80CSF1R0.67882950
81FGFR10.67008875
82FLT30.66388041
83CSNK1A1L0.66185267
84CDK10.65982146
85LYN0.64587185
86GRK10.63217434
87CSNK1G10.60584194
88EPHA20.60477471
89CDK80.59724124
90RAF10.59534395
91PRKCI0.58115888
92MAP2K30.57327648
93NEK60.56991788
94CSNK1E0.56935446
95TRPM70.55716747
96RPS6KA50.53704604
97IKBKB0.53598012
98NEK90.52654920
99TGFBR10.51567783
100CHUK0.51466247
101MET0.50388574
102CDK60.49802238
103CSNK2A20.49698187
104TAOK20.49525278
105LATS20.48649844
106CSNK1G30.47456722
107STK30.46725459
108BMPR20.46562617
109BLK0.46470920
110MATK0.45917258
111ERBB30.43804560
112TYK20.42468189
113CDK90.41866608
114PAK40.41772779
115SMG10.41438356
116JAK30.41402387
117AKT30.40483895
118RPS6KC10.40348216
119RPS6KL10.40348216
120CSNK1D0.39814598
121AKT10.38857955
122TESK20.38769207
123CAMK1D0.38592455
124ARAF0.38105480
125MAP3K100.36112834
126MAPK140.36062853
127LCK0.35589910
128RPS6KA60.35459638
129PLK20.35399961
130EEF2K0.35112906
131RPS6KB10.34786168
132ALK0.33474208
133PRKDC0.32541158
134DAPK10.32478465
135MST1R0.32321886
136CAMK1G0.28706669
137MARK30.28521743

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08269446
2Mismatch repair_Homo sapiens_hsa034304.71321959
3Homologous recombination_Homo sapiens_hsa034403.66133252
4* Fanconi anemia pathway_Homo sapiens_hsa034603.37471045
5Base excision repair_Homo sapiens_hsa034103.16917597
6Nucleotide excision repair_Homo sapiens_hsa034202.98362575
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.91842383
8Cell cycle_Homo sapiens_hsa041102.83072589
9Spliceosome_Homo sapiens_hsa030402.79529318
10RNA polymerase_Homo sapiens_hsa030202.54008146
11Ribosome_Homo sapiens_hsa030102.40067706
12Non-homologous end-joining_Homo sapiens_hsa034502.39001440
13RNA transport_Homo sapiens_hsa030132.34287668
14One carbon pool by folate_Homo sapiens_hsa006702.33648969
15Basal transcription factors_Homo sapiens_hsa030222.30907467
16Pyrimidine metabolism_Homo sapiens_hsa002402.16312328
17RNA degradation_Homo sapiens_hsa030181.95663918
18Proteasome_Homo sapiens_hsa030501.80651716
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69116834
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.59692773
21p53 signaling pathway_Homo sapiens_hsa041151.59306743
22Steroid biosynthesis_Homo sapiens_hsa001001.58973314
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58575613
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51227761
25mRNA surveillance pathway_Homo sapiens_hsa030151.49383990
26Systemic lupus erythematosus_Homo sapiens_hsa053221.38301179
27Selenocompound metabolism_Homo sapiens_hsa004501.33204731
28Herpes simplex infection_Homo sapiens_hsa051681.32261658
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29470914
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26020720
31Biosynthesis of amino acids_Homo sapiens_hsa012301.23836954
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22114440
33Purine metabolism_Homo sapiens_hsa002301.20707376
34Primary immunodeficiency_Homo sapiens_hsa053401.11755094
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.06345606
36Lysine degradation_Homo sapiens_hsa003101.06024461
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05987329
38Pyruvate metabolism_Homo sapiens_hsa006201.05018272
39Epstein-Barr virus infection_Homo sapiens_hsa051691.00623390
40Propanoate metabolism_Homo sapiens_hsa006401.00206757
41Carbon metabolism_Homo sapiens_hsa012000.92444176
42Measles_Homo sapiens_hsa051620.91201550
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87903935
44Viral carcinogenesis_Homo sapiens_hsa052030.87648584
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85129415
46Hematopoietic cell lineage_Homo sapiens_hsa046400.84810012
47Asthma_Homo sapiens_hsa053100.84398864
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82596367
49Antigen processing and presentation_Homo sapiens_hsa046120.82342800
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.82212791
51Allograft rejection_Homo sapiens_hsa053300.80029832
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77328733
53Fatty acid biosynthesis_Homo sapiens_hsa000610.76662138
54Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76437838
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73570994
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73513064
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71987343
58Autoimmune thyroid disease_Homo sapiens_hsa053200.70588302
59HTLV-I infection_Homo sapiens_hsa051660.70100753
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68594458
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68023234
62Graft-versus-host disease_Homo sapiens_hsa053320.67500544
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66863842
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64572410
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63530360
66Influenza A_Homo sapiens_hsa051640.62907053
67Legionellosis_Homo sapiens_hsa051340.62141917
68Leishmaniasis_Homo sapiens_hsa051400.60205948
69MicroRNAs in cancer_Homo sapiens_hsa052060.60175153
70Apoptosis_Homo sapiens_hsa042100.58027551
71Arachidonic acid metabolism_Homo sapiens_hsa005900.56513473
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55497238
73Small cell lung cancer_Homo sapiens_hsa052220.55455621
74Oocyte meiosis_Homo sapiens_hsa041140.55366346
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52768182
76Hepatitis B_Homo sapiens_hsa051610.50880818
77Sulfur relay system_Homo sapiens_hsa041220.50619840
78Fatty acid metabolism_Homo sapiens_hsa012120.49242139
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49074836
80Folate biosynthesis_Homo sapiens_hsa007900.48831868
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48329844
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47046999
83Protein export_Homo sapiens_hsa030600.46769228
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.46001170
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.45989561
86Fatty acid elongation_Homo sapiens_hsa000620.45588603
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45132136
88Vitamin digestion and absorption_Homo sapiens_hsa049770.45029125
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44694818
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44589302
91Notch signaling pathway_Homo sapiens_hsa043300.43241674
92Metabolic pathways_Homo sapiens_hsa011000.42372669
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42124996
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41785011
95Alcoholism_Homo sapiens_hsa050340.39866488
96Hippo signaling pathway_Homo sapiens_hsa043900.39469375
97Vitamin B6 metabolism_Homo sapiens_hsa007500.39321313
98Colorectal cancer_Homo sapiens_hsa052100.39168251
99Adherens junction_Homo sapiens_hsa045200.39034817
100TNF signaling pathway_Homo sapiens_hsa046680.34221540
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33407408
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33222466
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32660635
104Shigellosis_Homo sapiens_hsa051310.31704560
105Pertussis_Homo sapiens_hsa051330.31522710
106Sulfur metabolism_Homo sapiens_hsa009200.31225759
107Acute myeloid leukemia_Homo sapiens_hsa052210.29673297
108Linoleic acid metabolism_Homo sapiens_hsa005910.29396275
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28913234
110Other glycan degradation_Homo sapiens_hsa005110.28716660
111Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28632946
112Fatty acid degradation_Homo sapiens_hsa000710.28248262
113Thyroid cancer_Homo sapiens_hsa052160.28179660
114Sphingolipid metabolism_Homo sapiens_hsa006000.27923301
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.27263698
116Pathways in cancer_Homo sapiens_hsa052000.27076260
117B cell receptor signaling pathway_Homo sapiens_hsa046620.26361803
118TGF-beta signaling pathway_Homo sapiens_hsa043500.25285893
119Huntingtons disease_Homo sapiens_hsa050160.24738063
120Ether lipid metabolism_Homo sapiens_hsa005650.24718439
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24577466
122Arginine biosynthesis_Homo sapiens_hsa002200.24303719
123Type I diabetes mellitus_Homo sapiens_hsa049400.23902530
124Malaria_Homo sapiens_hsa051440.22239710
125Bladder cancer_Homo sapiens_hsa052190.21749230
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.21407269
127N-Glycan biosynthesis_Homo sapiens_hsa005100.21280730
128Pentose phosphate pathway_Homo sapiens_hsa000300.21279171
129Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20888685
130Prostate cancer_Homo sapiens_hsa052150.20756093
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.20025226
132Glutathione metabolism_Homo sapiens_hsa004800.19907454
133FoxO signaling pathway_Homo sapiens_hsa040680.19756039
134Basal cell carcinoma_Homo sapiens_hsa052170.19690880
135Pancreatic cancer_Homo sapiens_hsa052120.19652830
136Toxoplasmosis_Homo sapiens_hsa051450.19205384
137Tuberculosis_Homo sapiens_hsa051520.18406637
138Viral myocarditis_Homo sapiens_hsa054160.17434481
139Peroxisome_Homo sapiens_hsa041460.15665919
140Wnt signaling pathway_Homo sapiens_hsa043100.15587409
141Caffeine metabolism_Homo sapiens_hsa002320.15188524
142Butanoate metabolism_Homo sapiens_hsa006500.13783743
143Phototransduction_Homo sapiens_hsa047440.13716126
144Melanoma_Homo sapiens_hsa052180.12384488
145Parkinsons disease_Homo sapiens_hsa050120.12176697
146Tight junction_Homo sapiens_hsa045300.11658270

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