PALLD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)6.33088892
2sarcomere organization (GO:0045214)6.31121840
3muscle filament sliding (GO:0030049)5.90771816
4actin-myosin filament sliding (GO:0033275)5.90771816
5myofibril assembly (GO:0030239)5.40264380
6actin-mediated cell contraction (GO:0070252)5.26889548
7cardiac muscle cell development (GO:0055013)4.92672879
8plasma membrane repair (GO:0001778)4.72532063
9cardiac cell development (GO:0055006)4.71265072
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.69768082
11actomyosin structure organization (GO:0031032)4.52441351
12cardiac muscle tissue morphogenesis (GO:0055008)4.47348406
13negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.44921637
14ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.36339919
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.12664276
16muscle tissue morphogenesis (GO:0060415)4.10854588
17negative regulation of striated muscle cell apoptotic process (GO:0010664)4.09287203
18chondrocyte proliferation (GO:0035988)4.07914170
19actin filament-based movement (GO:0030048)4.02963512
20cardiac muscle contraction (GO:0060048)4.00842848
21regulation of skeletal muscle contraction (GO:0014819)4.00767540
22regulation of cardioblast differentiation (GO:0051890)3.82223183
23heart trabecula formation (GO:0060347)3.80582858
24ventricular cardiac muscle cell development (GO:0055015)3.78223287
25adult heart development (GO:0007512)3.78124266
26collagen fibril organization (GO:0030199)3.73192890
27glomerular basement membrane development (GO:0032836)3.64865382
28sequestering of extracellular ligand from receptor (GO:0035581)3.62869177
29negative regulation of potassium ion transmembrane transport (GO:1901380)3.60741270
30epithelial cell-cell adhesion (GO:0090136)3.60464196
31atrial septum morphogenesis (GO:0060413)3.56961127
32desmosome organization (GO:0002934)3.55558872
33trabecula formation (GO:0060343)3.52112817
34endodermal cell differentiation (GO:0035987)3.47184119
35endocardial cushion development (GO:0003197)3.46601876
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44755408
37bone trabecula formation (GO:0060346)3.42907816
38cardiac muscle hypertrophy (GO:0003300)3.41702928
39protein heterotrimerization (GO:0070208)3.41249718
40wound healing, spreading of epidermal cells (GO:0035313)3.34024425
41atrioventricular valve morphogenesis (GO:0003181)3.33356875
42regulation of actin filament-based movement (GO:1903115)3.33332983
43regulation of relaxation of muscle (GO:1901077)3.33162862
44kidney mesenchyme development (GO:0072074)3.27294092
45heart process (GO:0003015)3.25780934
46heart contraction (GO:0060047)3.25780934
47striated muscle hypertrophy (GO:0014897)3.23239683
48ventricular cardiac muscle cell action potential (GO:0086005)3.22560778
49regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.22371365
50paraxial mesoderm development (GO:0048339)3.19986343
51cardiac right ventricle morphogenesis (GO:0003215)3.18956598
52hemidesmosome assembly (GO:0031581)3.18825518
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.18513919
54positive regulation of endothelial cell apoptotic process (GO:2000353)3.18181355
55regulation of sarcomere organization (GO:0060297)3.17785384
56regulation of transforming growth factor beta2 production (GO:0032909)3.14059573
57cell adhesion mediated by integrin (GO:0033627)3.11999057
58extracellular matrix assembly (GO:0085029)3.11471493
59striated muscle contraction (GO:0006941)3.11044587
60outflow tract septum morphogenesis (GO:0003148)3.07414499
61gap junction assembly (GO:0016264)3.07245287
62regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.03339721
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.02727401
64skin morphogenesis (GO:0043589)3.02639249
65negative regulation of chondrocyte differentiation (GO:0032331)3.00776193
66negative regulation of protein localization to cell surface (GO:2000009)3.00741495
67response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.99134768
68renal filtration (GO:0097205)2.98103133
69regulation of integrin-mediated signaling pathway (GO:2001044)2.97216239
70basement membrane organization (GO:0071711)2.96826483
71peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.96230023
72regulation of tight junction assembly (GO:2000810)2.95176693
73muscle hypertrophy (GO:0014896)2.94834091
74glomerular filtration (GO:0003094)2.93407735
75muscle cell fate commitment (GO:0042693)2.92499699
76regulation of striated muscle cell apoptotic process (GO:0010662)2.92452885
77regulation of striated muscle contraction (GO:0006942)2.92279959
78striated muscle cell development (GO:0055002)2.88061100
79cell-substrate junction assembly (GO:0007044)2.87626731
80extracellular fibril organization (GO:0043206)2.86216671
81cell migration involved in heart development (GO:0060973)2.85133715
82myoblast fusion (GO:0007520)2.83484497
83smooth muscle tissue development (GO:0048745)2.82998373
84hippo signaling (GO:0035329)2.81681972
85vascular endothelial growth factor signaling pathway (GO:0038084)2.81514147
86actin filament depolymerization (GO:0030042)2.79990341
87cell migration involved in sprouting angiogenesis (GO:0002042)2.79560489
88regulation of the force of heart contraction (GO:0002026)2.79309219
89cell communication involved in cardiac conduction (GO:0086065)2.76006518
90carnitine shuttle (GO:0006853)2.75612587
91retina vasculature morphogenesis in camera-type eye (GO:0061299)2.72986675
92regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.72669532
93negative regulation of fatty acid transport (GO:2000192)2.72464777
94planar cell polarity pathway involved in neural tube closure (GO:0090179)2.71949708
95positive regulation of myotube differentiation (GO:0010831)2.70814221
96wound healing, spreading of cells (GO:0044319)2.68761751
97heart valve morphogenesis (GO:0003179)2.65873612
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.65414524
99axon extension involved in axon guidance (GO:0048846)2.65414524
100regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65353758
101collagen metabolic process (GO:0032963)2.65147090
102muscle cell cellular homeostasis (GO:0046716)2.63657350
103metanephric mesenchyme development (GO:0072075)2.63349779
104G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.63225301
105positive regulation of stem cell differentiation (GO:2000738)2.62388236
106fibroblast migration (GO:0010761)2.61301294
107substrate adhesion-dependent cell spreading (GO:0034446)2.60518065
108regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58972959
109mesenchymal-epithelial cell signaling (GO:0060638)2.58784909
110cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58691405
111collagen catabolic process (GO:0030574)2.57798066
112cellular response to vitamin D (GO:0071305)2.57437382
113regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.55966833
114regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.55860528
115cellular response to vitamin (GO:0071295)2.55192547
116positive regulation of epithelial to mesenchymal transition (GO:0010718)2.54537677
117muscle cell development (GO:0055001)2.54211380
118regulation of heart morphogenesis (GO:2000826)2.53898529
119fatty acid transmembrane transport (GO:1902001)2.53206461
120regulation of cell communication by electrical coupling (GO:0010649)2.51617770
121mesenchyme morphogenesis (GO:0072132)2.49681512
122cardiac muscle tissue development (GO:0048738)2.48932426
123mesenchyme development (GO:0060485)2.48382570
124multicellular organismal macromolecule metabolic process (GO:0044259)2.48324301
125cell communication by electrical coupling (GO:0010644)2.47819024
126syncytium formation by plasma membrane fusion (GO:0000768)2.47590510
127pericardium development (GO:0060039)2.46123772
128extracellular matrix disassembly (GO:0022617)2.44875162
129substrate-dependent cell migration (GO:0006929)2.44748818
130muscle contraction (GO:0006936)2.44642957
131muscle cell migration (GO:0014812)2.40584792
132multicellular organismal metabolic process (GO:0044236)2.36599843
133multicellular organismal catabolic process (GO:0044243)2.36001322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.01293668
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.92658785
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.40499079
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.10623196
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.85866903
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.76585658
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.51596639
8CLOCK_20551151_ChIP-Seq_293T_Human2.54797372
9TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.50607951
10* MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.48346580
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.44754284
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.41813918
13* TBX20_22080862_ChIP-Seq_HEART_Mouse2.37706209
14* TBX20_22328084_ChIP-Seq_HEART_Mouse2.37706209
15CJUN_26792858_Chip-Seq_BT549_Human2.35378316
16ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29806371
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.26550161
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16059618
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.15143215
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13411351
21ESR1_20079471_ChIP-ChIP_T-47D_Human2.12141736
22* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.11250755
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07722100
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.02748135
25* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.96436018
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.86809377
27CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.86707318
28SALL4_18804426_ChIP-ChIP_XEN_Mouse1.81741817
29SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.81338098
30SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.81338098
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.80631636
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74026070
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73770795
34NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72730916
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69123925
36NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67847416
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67847416
38* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67624094
39* BRD4_25478319_ChIP-Seq_HGPS_Human1.65377453
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.64967533
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.63700273
42* PIAS1_25552417_ChIP-Seq_VCAP_Human1.63273866
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.62705018
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58081497
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.57587710
46ISL1_27105846_Chip-Seq_CPCs_Mouse1.56198016
47NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.55389336
48GATA4_21415370_ChIP-Seq_HL-1_Mouse1.53049260
49SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52232052
50GBX2_23144817_ChIP-Seq_PC3_Human1.51146183
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.50991709
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49952702
53LXR_22158963_ChIP-Seq_LIVER_Mouse1.48728342
54PPARA_22158963_ChIP-Seq_LIVER_Mouse1.47735213
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.45381913
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44706319
57TP53_18474530_ChIP-ChIP_U2OS_Human1.43003874
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40532551
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34024831
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33784093
61AHR_22903824_ChIP-Seq_MCF-7_Human1.33708424
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33070462
63* UBF1/2_26484160_Chip-Seq_HMECs_Human1.30823653
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30690398
65* SOX2_20726797_ChIP-Seq_SW620_Human1.29952481
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29102248
67SMC1_22415368_ChIP-Seq_MEFs_Mouse1.28126979
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27469326
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26963388
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.26166935
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25982697
72* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.25114869
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23576287
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.23549639
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.22367492
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22023519
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.21840952
78SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20674419
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19383280
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19260318
81GATA2_21666600_ChIP-Seq_HMVEC_Human1.18610088
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17464541
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.17435535
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17122648
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16270678
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15406803
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13486158
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13292826
89* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13139841
90TP53_16413492_ChIP-PET_HCT116_Human1.12016954
91TCF3_18692474_ChIP-Seq_MEFs_Mouse1.10606461
92RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10108067
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07854328
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.06022163
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.05659190
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05386699
97ATF3_27146783_Chip-Seq_COLON_Human1.04571110
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00860431
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00406008
100FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99813673
101NFI_21473784_ChIP-Seq_ESCs_Mouse0.99758834
102SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.99391850
103* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98697758
104SA1_22415368_ChIP-Seq_MEFs_Mouse0.98328292
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97217271
106* TP53_23651856_ChIP-Seq_MEFs_Mouse0.96979652
107PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96231681
108SMAD3_21741376_ChIP-Seq_EPCs_Human0.95666059
109RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95248789
110FOXO3_23340844_ChIP-Seq_DLD1_Human0.95029112
111* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94899541
112RACK7_27058665_Chip-Seq_MCF-7_Human0.94561695
113JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94065957
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94054681
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93561866
116* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93272368
117* SMAD3_21741376_ChIP-Seq_HESCs_Human0.92160226
118JARID2_20064375_ChIP-Seq_MESCs_Mouse0.92004575
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90988269
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89930975
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89720001
122PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89355198
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.88593237
124TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.87007794
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86880635
126* TP63_23658742_ChIP-Seq_EP156T_Human0.84830685
127ZNF263_19887448_ChIP-Seq_K562_Human0.84643766
128RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84601010
129EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84601010
130* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82658041
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.81025181
132BCAT_22108803_ChIP-Seq_LS180_Human0.79733540
133* TP53_22127205_ChIP-Seq_IMR90_Human0.79315143
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77928775
135NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77559091
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76443714
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75519699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.56887241
2MP0004084_abnormal_cardiac_muscle3.93023960
3MP0005275_abnormal_skin_tensile3.18675107
4MP0002837_dystrophic_cardiac_calcinosis3.02813401
5MP0005503_abnormal_tendon_morphology2.88226658
6MP0003705_abnormal_hypodermis_morpholog2.80391906
7MP0003279_aneurysm2.71802196
8MP0000749_muscle_degeneration2.67430957
9MP0004272_abnormal_basement_membrane2.62962744
10MP0005330_cardiomyopathy2.62704874
11MP0000751_myopathy2.56493662
12MP0004036_abnormal_muscle_relaxation2.56078322
13MP0009384_cardiac_valve_regurgitation2.38962851
14MP0005623_abnormal_meninges_morphology2.38724824
15MP0009780_abnormal_chondrocyte_physiolo2.35809824
16MP0004215_abnormal_myocardial_fiber2.27949650
17MP0002972_abnormal_cardiac_muscle2.21020636
18MP0004087_abnormal_muscle_fiber2.14054265
19MP0003941_abnormal_skin_development2.13753236
20MP0000750_abnormal_muscle_regeneration2.12082210
21MP0008775_abnormal_heart_ventricle2.11099432
22MP0003828_pulmonary_edema2.10217666
23MP0006138_congestive_heart_failure2.08949510
24MP0000013_abnormal_adipose_tissue2.05302111
25MP0010630_abnormal_cardiac_muscle1.99092415
26MP0010030_abnormal_orbit_morphology1.95459265
27MP0010368_abnormal_lymphatic_system1.95444111
28* MP0003566_abnormal_cell_adhesion1.91831452
29MP0005620_abnormal_muscle_contractility1.87318613
30MP0005385_cardiovascular_system_phenoty1.82088784
31MP0001544_abnormal_cardiovascular_syste1.82088784
32MP0003646_muscle_fatigue1.77294886
33MP0003385_abnormal_body_wall1.70867826
34MP0003137_abnormal_impulse_conducting1.63530875
35MP0009250_abnormal_appendicular_skeleto1.57265770
36MP0009053_abnormal_anal_canal1.56203141
37MP0000579_abnormal_nail_morphology1.51359304
38MP0000733_abnormal_muscle_development1.50846732
39MP0001958_emphysema1.46576117
40MP0002106_abnormal_muscle_physiology1.45877940
41MP0004145_abnormal_muscle_electrophysio1.44731493
42MP0003950_abnormal_plasma_membrane1.44632755
43MP0005508_abnormal_skeleton_morphology1.42889939
44MP0003567_abnormal_fetal_cardiomyocyte1.42817619
45MP0000767_abnormal_smooth_muscle1.39626160
46MP0000759_abnormal_skeletal_muscle1.36757984
47MP0005369_muscle_phenotype1.33977590
48MP0002249_abnormal_larynx_morphology1.28994062
49MP0001879_abnormal_lymphatic_vessel1.27101479
50MP0002060_abnormal_skin_morphology1.26639528
51MP0002269_muscular_atrophy1.25824111
52MP0005023_abnormal_wound_healing1.24923793
53MP0005257_abnormal_intraocular_pressure1.24339014
54MP0004484_altered_response_of1.21929943
55MP0002127_abnormal_cardiovascular_syste1.20536199
56MP0002108_abnormal_muscle_morphology1.17902179
57MP0006054_spinal_hemorrhage1.17398453
58MP0000462_abnormal_digestive_system1.17128643
59MP0000762_abnormal_tongue_morphology1.16042226
60MP0002282_abnormal_trachea_morphology1.15061264
61MP0002295_abnormal_pulmonary_circulatio1.14365442
62MP0002128_abnormal_blood_circulation1.11430370
63MP0000049_abnormal_middle_ear1.11109990
64MP0004085_abnormal_heartbeat1.05964516
65MP0000003_abnormal_adipose_tissue1.05669310
66MP0003942_abnormal_urinary_system1.05180422
67MP0002234_abnormal_pharynx_morphology1.03012051
68MP0000266_abnormal_heart_morphology1.02085754
69MP0004233_abnormal_muscle_weight0.99490955
70MP0003221_abnormal_cardiomyocyte_apopto0.97317621
71MP0003755_abnormal_palate_morphology0.96448137
72MP0000747_muscle_weakness0.96447391
73MP0003283_abnormal_digestive_organ0.96318782
74MP0000428_abnormal_craniofacial_morphol0.95027764
75MP0005409_darkened_coat_color0.94932139
76MP0003935_abnormal_craniofacial_develop0.93510790
77MP0010352_gastrointestinal_tract_polyps0.91330795
78MP0001542_abnormal_bone_strength0.91184205
79MP0003937_abnormal_limbs/digits/tail_de0.89943612
80MP0004130_abnormal_muscle_cell0.89818439
81MP0005666_abnormal_adipose_tissue0.89168561
82* MP0003091_abnormal_cell_migration0.88742236
83MP0002896_abnormal_bone_mineralization0.87769597
84MP0000163_abnormal_cartilage_morphology0.87545451
85MP0004510_myositis0.86883321
86MP0000343_altered_response_to0.86585941
87MP0004134_abnormal_chest_morphology0.86464300
88MP0005451_abnormal_body_composition0.85977519
89MP0000467_abnormal_esophagus_morphology0.85424293
90MP0005367_renal/urinary_system_phenotyp0.85026717
91MP0000516_abnormal_urinary_system0.85026717
92MP0001614_abnormal_blood_vessel0.84897720
93MP0003115_abnormal_respiratory_system0.84560217
94MP0002168_other_aberrant_phenotype0.83862147
95MP0002932_abnormal_joint_morphology0.82752730
96MP0002925_abnormal_cardiovascular_devel0.82350982
97MP0005165_increased_susceptibility_to0.81334702
98MP0000537_abnormal_urethra_morphology0.80503517
99MP0005595_abnormal_vascular_smooth0.80428890
100MP0003045_fibrosis0.79262215
101MP0001243_abnormal_dermal_layer0.77451220
102MP0000534_abnormal_ureter_morphology0.76349498
103MP0002877_abnormal_melanocyte_morpholog0.74439052
104MP0010386_abnormal_urinary_bladder0.74360776
105MP0000432_abnormal_head_morphology0.74236966
106MP0001299_abnormal_eye_distance/0.73652615
107MP0005197_abnormal_uvea_morphology0.73510107
108MP0000538_abnormal_urinary_bladder0.72174868
109MP0001348_abnormal_lacrimal_gland0.72001145
110MP0005670_abnormal_white_adipose0.70288318
111MP0005187_abnormal_penis_morphology0.69479632
112MP0002233_abnormal_nose_morphology0.69074983
113MP0002115_abnormal_skeleton_extremities0.68665892
114MP0001849_ear_inflammation0.68500741
115MP0005390_skeleton_phenotype0.68451663
116MP0010234_abnormal_vibrissa_follicle0.68224371
117MP0005248_abnormal_Harderian_gland0.65574027
118MP0001661_extended_life_span0.64870932
119MP0005193_abnormal_anterior_eye0.63667152

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.68484982
2Protrusio acetabuli (HP:0003179)5.66945790
3Sudden death (HP:0001699)5.40505257
4Right ventricular cardiomyopathy (HP:0011663)5.01015528
5Ventricular tachycardia (HP:0004756)4.88260157
6Lipoatrophy (HP:0100578)4.22002779
7Atrial fibrillation (HP:0005110)4.17346087
8Vascular tortuosity (HP:0004948)4.12554374
9Muscle fiber splitting (HP:0003555)4.08948871
10Abnormality of the calf musculature (HP:0001430)4.05272826
11Type 1 muscle fiber predominance (HP:0003803)4.04751032
12Increased connective tissue (HP:0009025)3.95483206
13Arterial tortuosity (HP:0005116)3.90007641
14Primary atrial arrhythmia (HP:0001692)3.85881788
15Subaortic stenosis (HP:0001682)3.82791947
16Abnormality of the left ventricular outflow tract (HP:0011103)3.82791947
17Aortic dissection (HP:0002647)3.82204259
18Supraventricular arrhythmia (HP:0005115)3.69136763
19Supraventricular tachycardia (HP:0004755)3.68175632
20Atrophic scars (HP:0001075)3.66880115
21Hyporeflexia of lower limbs (HP:0002600)3.63561200
22Calf muscle hypertrophy (HP:0008981)3.62911429
23Exercise-induced muscle cramps (HP:0003710)3.47869006
24Shallow orbits (HP:0000586)3.29250904
25Aortic aneurysm (HP:0004942)3.20724897
26Muscle hypertrophy of the lower extremities (HP:0008968)3.17025219
27Ankle contracture (HP:0006466)3.16642534
28Dilated cardiomyopathy (HP:0001644)3.14239419
29EMG: myopathic abnormalities (HP:0003458)3.12740083
30Fragile skin (HP:0001030)3.10202292
31Peritonitis (HP:0002586)3.09174128
32Broad metatarsal (HP:0001783)3.02897691
33Popliteal pterygium (HP:0009756)3.00430390
34Spinal rigidity (HP:0003306)2.92927420
35Mildly elevated creatine phosphokinase (HP:0008180)2.87411665
36Exercise-induced myalgia (HP:0003738)2.84672743
37Soft skin (HP:0000977)2.83369986
38Ventricular arrhythmia (HP:0004308)2.82031777
39Distal lower limb muscle weakness (HP:0009053)2.76005704
40Syncope (HP:0001279)2.74109392
41Cerebral aneurysm (HP:0004944)2.60236866
42Spondylolisthesis (HP:0003302)2.58614653
43Round ear (HP:0100830)2.56691347
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.47684576
45Scapular winging (HP:0003691)2.46970503
46Hip contracture (HP:0003273)2.46871423
47Abnormality of dentin (HP:0010299)2.45180936
48Dilatation of the ascending aorta (HP:0005111)2.44941495
49Prolonged QT interval (HP:0001657)2.44707247
50Difficulty climbing stairs (HP:0003551)2.43874209
51Blue sclerae (HP:0000592)2.38804726
52Asymmetric septal hypertrophy (HP:0001670)2.37931451
53Knee flexion contracture (HP:0006380)2.33853852
54Aortic regurgitation (HP:0001659)2.33039446
55Palpitations (HP:0001962)2.32053662
56Increased variability in muscle fiber diameter (HP:0003557)2.30569537
57Muscle fiber inclusion bodies (HP:0100299)2.29684493
58Abnormal atrioventricular conduction (HP:0005150)2.27077626
59Ulnar bowing (HP:0003031)2.22578703
60Neonatal short-limb short stature (HP:0008921)2.20800058
61Atrioventricular block (HP:0001678)2.19459048
62Bladder diverticulum (HP:0000015)2.18757234
63Wide anterior fontanel (HP:0000260)2.18041612
64Abnormality of skeletal muscle fiber size (HP:0012084)2.16335164
65Mitral valve prolapse (HP:0001634)2.16152316
66Mitral regurgitation (HP:0001653)2.13527666
67Osteolytic defects of the hand bones (HP:0009699)2.11752139
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.11752139
69Myoglobinuria (HP:0002913)2.11240066
70Aneurysm (HP:0002617)2.09834958
71Distal lower limb amyotrophy (HP:0008944)2.09066224
72Biconcave vertebral bodies (HP:0004586)2.09009553
73Pulmonary artery stenosis (HP:0004415)2.08020502
74Coronal craniosynostosis (HP:0004440)2.06020971
75Mitral stenosis (HP:0001718)2.04791072
76Absent frontal sinuses (HP:0002688)2.04567042
77Wormian bones (HP:0002645)2.04120930
78Abnormal delivery (HP:0001787)2.03539193
79Gowers sign (HP:0003391)2.03012578
80Bowel diverticulosis (HP:0005222)2.01820078
81Hyperextensible skin (HP:0000974)2.01419796
82Wrist flexion contracture (HP:0001239)1.99159127
83Heart block (HP:0012722)1.97180212
84Vertebral compression fractures (HP:0002953)1.96195325
85Difficulty running (HP:0009046)1.96043977
86Calcaneovalgus deformity (HP:0001848)1.95773931
87Ulnar deviation of the wrist (HP:0003049)1.95758203
88Rhabdomyolysis (HP:0003201)1.95311787
89Elbow flexion contracture (HP:0002987)1.94750480
90Cervical subluxation (HP:0003308)1.93379188
91Distal arthrogryposis (HP:0005684)1.91041979
92Joint laxity (HP:0001388)1.90201313
93Bradycardia (HP:0001662)1.89507282
94Neck muscle weakness (HP:0000467)1.88956888
95Deformed tarsal bones (HP:0008119)1.87427602
96Slender build (HP:0001533)1.86559687
97Morphological abnormality of the middle ear (HP:0008609)1.86212720
98Limited hip movement (HP:0008800)1.86141229
99Abnormality of the neuromuscular junction (HP:0003398)1.85660931
100Fatigable weakness (HP:0003473)1.85660931
101Palmoplantar keratoderma (HP:0000982)1.85420247
102Nemaline bodies (HP:0003798)1.84949559
103Abnormality of the ischium (HP:0003174)1.84897773
104Hypoplastic ischia (HP:0003175)1.83506635
105Short nail (HP:0001799)1.83332099
106Mesangial abnormality (HP:0001966)1.83055066
107Thin ribs (HP:0000883)1.82787693
108Lymphangioma (HP:0100764)1.82676614
109Generalized muscle weakness (HP:0003324)1.81496808
110Mesomelia (HP:0003027)1.79776171
111Hypoplasia of the iris (HP:0007676)1.79290589
112Generalized amyotrophy (HP:0003700)1.79007326
113Ectopia lentis (HP:0001083)1.77544729
114Tibial bowing (HP:0002982)1.77529223
115Breech presentation (HP:0001623)1.76918088
116Pterygium (HP:0001059)1.76262689
117Delayed gross motor development (HP:0002194)1.76055907
118Natal tooth (HP:0000695)1.75793552
119Overgrowth (HP:0001548)1.75227172
120Infantile muscular hypotonia (HP:0008947)1.75218295
121Absent phalangeal crease (HP:0006109)1.74790832
122Limb-girdle muscle atrophy (HP:0003797)1.74399541
123Camptodactyly of toe (HP:0001836)1.72465641
124Hypoplastic heart (HP:0001961)1.72084960
125Genu recurvatum (HP:0002816)1.71381577
126Follicular hyperkeratosis (HP:0007502)1.70578816
127Bundle branch block (HP:0011710)1.69506925
128Thin bony cortex (HP:0002753)1.68209687
129Syringomyelia (HP:0003396)1.68044517
130Spinal cord lesions (HP:0100561)1.68044517

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.31921331
2MYLK4.25602562
3OBSCN3.98430557
4PKN23.09224370
5EPHB22.96976751
6LATS12.73513059
7TRIB32.71557749
8PIK3CA2.70689470
9STK38L2.57137982
10DMPK2.52820505
11STK242.17323263
12LMTK22.07856989
13LATS21.93656233
14DDR21.83879168
15ZAK1.78889704
16TRPM71.76226109
17FER1.72109911
18PDGFRA1.71411061
19PAK31.61625879
20PAK21.58607540
21MUSK1.53354448
22NTRK11.52754877
23PIK3CG1.51015959
24ILK1.48293440
25TIE11.43879943
26ROCK11.43535426
27EPHA31.41125162
28SIK11.34036815
29CDC42BPA1.29222230
30STK31.29128819
31PHKG11.28334240
32PHKG21.28334240
33LIMK11.26178386
34TESK11.24584140
35NEK91.24554807
36BCKDK1.23864043
37RIPK11.14885526
38NME21.13813495
39MAP3K121.09688019
40PIM21.07500212
41MARK11.04635641
42PTK2B1.04115389
43FLT31.03172670
44DAPK31.01841259
45PTK60.98488096
46PTK20.96998283
47MOS0.96428182
48GRK70.94381913
49TGFBR20.92206709
50PRKD10.90845477
51PDK40.89418030
52PDK30.89418030
53ERN10.89333503
54NUAK10.88631845
55KDR0.85283208
56MAP3K30.84373893
57AKT30.82256840
58PRKG20.81501836
59MAP3K70.80758155
60CAMK2G0.79633261
61MAPKAPK30.76560946
62FGFR10.76279609
63MET0.74680177
64EPHA20.74503725
65LRRK20.70885337
66MAP3K60.69771536
67NEK10.69712896
68BMX0.69566173
69PDK20.69449710
70PNCK0.66771556
71PRKAA20.64692544
72RPS6KA40.64630525
73STK40.64513891
74RPS6KA20.64274230
75MAPK70.60897802
76ERBB40.58717785
77GSK3A0.58461844
78ABL20.58020065
79PAK40.57643332
80MTOR0.57256200
81MAP3K50.55780758
82CAMK2D0.54820443
83ROCK20.54333151
84STK390.53686247
85CAMK2B0.53317788
86TGFBR10.53086795
87WNK40.52972634
88PINK10.52205509
89WNK10.51816292
90PRKD20.48586715
91ERBB20.47946825
92MAP2K10.47093487
93MELK0.46851811
94CAMK2A0.44761485
95PAK60.44723111
96EPHB10.44473493
97ERBB30.43201867
98MAP3K100.43158027
99FGFR20.41106675
100CDK60.40524181
101DYRK1B0.40468336
102MAP2K30.40259778
103EIF2AK20.39126897
104KSR10.39026001
105RET0.37525619
106AKT20.36713926
107CAMK1G0.36611517
108PRKCE0.36399176
109PRKD30.36312299
110STK380.36084015
111NLK0.35050692
112CAMK10.34492164
113MAPKAPK20.34471030
114MAPK120.33946256
115PLK20.33738313
116RPS6KC10.33367284
117RPS6KL10.33367284
118MST1R0.33139269
119MKNK10.32829317
120ADRBK10.31894525
121MKNK20.31566642
122PAK10.30365797
123FGFR40.29133117
124PDGFRB0.29113945
125PRKAA10.28923033
126BCR0.28667838
127TAOK20.28628808
128PRKG10.28585092
129ICK0.28329587
130INSR0.26557163
131FRK0.23113222

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.23116635
2Dilated cardiomyopathy_Homo sapiens_hsa054143.93399902
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.31771748
4ECM-receptor interaction_Homo sapiens_hsa045123.07028200
5Cardiac muscle contraction_Homo sapiens_hsa042603.06109842
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90689409
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.50999505
8Focal adhesion_Homo sapiens_hsa045102.40748449
9Fatty acid degradation_Homo sapiens_hsa000712.21703867
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97922954
11Viral myocarditis_Homo sapiens_hsa054161.92108138
12Adherens junction_Homo sapiens_hsa045201.90406986
13Propanoate metabolism_Homo sapiens_hsa006401.76162760
14Amoebiasis_Homo sapiens_hsa051461.70835755
15Proteoglycans in cancer_Homo sapiens_hsa052051.68114444
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61258208
17Basal cell carcinoma_Homo sapiens_hsa052171.59509272
18Hippo signaling pathway_Homo sapiens_hsa043901.49628665
19Carbon metabolism_Homo sapiens_hsa012001.49466796
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47810605
21Small cell lung cancer_Homo sapiens_hsa052221.47392721
22Fatty acid metabolism_Homo sapiens_hsa012121.46834779
23Tight junction_Homo sapiens_hsa045301.44932305
24Circadian rhythm_Homo sapiens_hsa047101.44272470
25TGF-beta signaling pathway_Homo sapiens_hsa043501.43757654
26PPAR signaling pathway_Homo sapiens_hsa033201.30238765
27Starch and sucrose metabolism_Homo sapiens_hsa005001.27999049
28Tryptophan metabolism_Homo sapiens_hsa003801.27996528
29Protein digestion and absorption_Homo sapiens_hsa049741.27740590
30Bladder cancer_Homo sapiens_hsa052191.26393065
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23408415
32Renin secretion_Homo sapiens_hsa049241.21787700
33Parkinsons disease_Homo sapiens_hsa050121.19436948
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19232938
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14252143
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13364007
37Malaria_Homo sapiens_hsa051441.13180843
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11365000
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.09835880
40Axon guidance_Homo sapiens_hsa043601.04692212
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03438437
42Complement and coagulation cascades_Homo sapiens_hsa046101.03094138
43MicroRNAs in cancer_Homo sapiens_hsa052061.02399543
44Gap junction_Homo sapiens_hsa045401.01944700
45Oxidative phosphorylation_Homo sapiens_hsa001900.99442637
46Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96245184
47Hedgehog signaling pathway_Homo sapiens_hsa043400.95252674
48HIF-1 signaling pathway_Homo sapiens_hsa040660.94660059
49PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94586657
50Insulin secretion_Homo sapiens_hsa049110.94508692
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94295245
52Lysine degradation_Homo sapiens_hsa003100.92822771
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90264624
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88407340
55p53 signaling pathway_Homo sapiens_hsa041150.88378132
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87656448
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87434375
58Oxytocin signaling pathway_Homo sapiens_hsa049210.86924943
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85055692
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84825798
61Fatty acid elongation_Homo sapiens_hsa000620.83775012
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.82235951
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82078389
64Biosynthesis of amino acids_Homo sapiens_hsa012300.78476188
65Insulin resistance_Homo sapiens_hsa049310.78219487
66cAMP signaling pathway_Homo sapiens_hsa040240.76688801
67Alzheimers disease_Homo sapiens_hsa050100.76351720
68Pyruvate metabolism_Homo sapiens_hsa006200.75959674
69Sulfur metabolism_Homo sapiens_hsa009200.75467106
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75223050
71Arginine biosynthesis_Homo sapiens_hsa002200.73508970
72Phenylalanine metabolism_Homo sapiens_hsa003600.73347961
73Arginine and proline metabolism_Homo sapiens_hsa003300.73074155
74Thyroid hormone synthesis_Homo sapiens_hsa049180.72960963
75Melanoma_Homo sapiens_hsa052180.71459589
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71340065
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71309243
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71219422
79Calcium signaling pathway_Homo sapiens_hsa040200.70035270
80Huntingtons disease_Homo sapiens_hsa050160.68805723
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68726208
82Pathways in cancer_Homo sapiens_hsa052000.67877777
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.67142337
84Renal cell carcinoma_Homo sapiens_hsa052110.66160186
85beta-Alanine metabolism_Homo sapiens_hsa004100.65906841
86Gastric acid secretion_Homo sapiens_hsa049710.64936493
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64059130
88Glioma_Homo sapiens_hsa052140.63023099
89Galactose metabolism_Homo sapiens_hsa000520.62430908
90Toxoplasmosis_Homo sapiens_hsa051450.61879215
91Chemical carcinogenesis_Homo sapiens_hsa052040.61736174
92Wnt signaling pathway_Homo sapiens_hsa043100.61279072
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.61088836
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.60266348
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60163187
96GnRH signaling pathway_Homo sapiens_hsa049120.59083588
97Endometrial cancer_Homo sapiens_hsa052130.57619781
98Peroxisome_Homo sapiens_hsa041460.56702316
99Pancreatic secretion_Homo sapiens_hsa049720.56529878
100Estrogen signaling pathway_Homo sapiens_hsa049150.56260187
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56215509
102Dorso-ventral axis formation_Homo sapiens_hsa043200.56067869
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55869461
104Cocaine addiction_Homo sapiens_hsa050300.54800657
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.52772737
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.51027650
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50989367
108Tyrosine metabolism_Homo sapiens_hsa003500.50833513
109Vibrio cholerae infection_Homo sapiens_hsa051100.49539309
110Prion diseases_Homo sapiens_hsa050200.49446013
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49110413
112Circadian entrainment_Homo sapiens_hsa047130.47707597
113Glucagon signaling pathway_Homo sapiens_hsa049220.47699027
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47106057
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46118226
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45201553
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.44346521
118AMPK signaling pathway_Homo sapiens_hsa041520.44151898
119Glutathione metabolism_Homo sapiens_hsa004800.43957440
120Insulin signaling pathway_Homo sapiens_hsa049100.43674239
121Prostate cancer_Homo sapiens_hsa052150.43456061
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42599430
123HTLV-I infection_Homo sapiens_hsa051660.42369158
124Retinol metabolism_Homo sapiens_hsa008300.42353179
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40651713
126Butanoate metabolism_Homo sapiens_hsa006500.40110556
127Folate biosynthesis_Homo sapiens_hsa007900.39492850
128Salivary secretion_Homo sapiens_hsa049700.39310643
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39276408
130Melanogenesis_Homo sapiens_hsa049160.39241840
131Notch signaling pathway_Homo sapiens_hsa043300.39128139
132Chronic myeloid leukemia_Homo sapiens_hsa052200.38287861
133Dopaminergic synapse_Homo sapiens_hsa047280.38012420
134FoxO signaling pathway_Homo sapiens_hsa040680.37495546
135Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37336294
136Platelet activation_Homo sapiens_hsa046110.37285305
137Mineral absorption_Homo sapiens_hsa049780.36498261
138Ovarian steroidogenesis_Homo sapiens_hsa049130.35428000
139Amphetamine addiction_Homo sapiens_hsa050310.35288226
140Thyroid cancer_Homo sapiens_hsa052160.35222230
141Cholinergic synapse_Homo sapiens_hsa047250.34822754
142Sphingolipid metabolism_Homo sapiens_hsa006000.34561933
143Ras signaling pathway_Homo sapiens_hsa040140.34553950
144Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34505894
145Rap1 signaling pathway_Homo sapiens_hsa040150.32889235
146Arachidonic acid metabolism_Homo sapiens_hsa005900.32827489
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32799737
148TNF signaling pathway_Homo sapiens_hsa046680.31652909

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