PALM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons and other cell types. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.41131440
2locomotory exploration behavior (GO:0035641)5.92783416
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.79870032
4layer formation in cerebral cortex (GO:0021819)5.60356096
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.40476395
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.09734757
7vocalization behavior (GO:0071625)5.04231656
8regulation of synapse structural plasticity (GO:0051823)5.01901976
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.97601457
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.94199267
11glutamate secretion (GO:0014047)4.81662638
12synaptic vesicle exocytosis (GO:0016079)4.78643679
13exploration behavior (GO:0035640)4.56179679
14regulation of glutamate receptor signaling pathway (GO:1900449)4.55545910
15regulation of synaptic vesicle exocytosis (GO:2000300)4.54202341
16dendritic spine morphogenesis (GO:0060997)4.53253588
17protein localization to synapse (GO:0035418)4.42932120
18positive regulation of synapse maturation (GO:0090129)4.39572420
19regulation of neuronal synaptic plasticity (GO:0048168)4.28954431
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.19646594
21axon ensheathment in central nervous system (GO:0032291)4.12803640
22central nervous system myelination (GO:0022010)4.12803640
23cell migration in hindbrain (GO:0021535)4.07634923
24regulation of synaptic vesicle transport (GO:1902803)4.02648872
25proline transport (GO:0015824)4.00653887
26cerebellar granule cell differentiation (GO:0021707)3.96646978
27neurotransmitter secretion (GO:0007269)3.92965867
28sodium ion export (GO:0071436)3.88449710
29response to pheromone (GO:0019236)3.83310634
30neuron recognition (GO:0008038)3.81889350
31activation of protein kinase A activity (GO:0034199)3.77258100
32auditory behavior (GO:0031223)3.76735305
33neuron cell-cell adhesion (GO:0007158)3.75451511
34negative regulation of microtubule polymerization (GO:0031115)3.74358122
35cell communication by electrical coupling (GO:0010644)3.73940002
36axonal fasciculation (GO:0007413)3.72439465
37L-amino acid import (GO:0043092)3.65450138
38neuromuscular process controlling balance (GO:0050885)3.64815656
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62773961
40dendrite morphogenesis (GO:0048813)3.61992988
41neurotransmitter-gated ion channel clustering (GO:0072578)3.60783845
42pyrimidine nucleobase catabolic process (GO:0006208)3.59566832
43regulation of dendritic spine morphogenesis (GO:0061001)3.58927304
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.58092028
45regulation of voltage-gated calcium channel activity (GO:1901385)3.56483332
46G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.49078317
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45717552
48potassium ion homeostasis (GO:0055075)3.45181436
49* positive regulation of dendritic spine development (GO:0060999)3.44697775
50cellular potassium ion homeostasis (GO:0030007)3.42857363
51cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.39984948
52establishment of nucleus localization (GO:0040023)3.38817220
53membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36925734
54positive regulation of membrane potential (GO:0045838)3.35368548
55cerebellar Purkinje cell layer development (GO:0021680)3.34223010
56synaptic transmission, glutamatergic (GO:0035249)3.32307790
57amino acid import (GO:0043090)3.29723126
58long-term memory (GO:0007616)3.28635306
59response to auditory stimulus (GO:0010996)3.27389566
60dopamine receptor signaling pathway (GO:0007212)3.25442814
61presynaptic membrane organization (GO:0097090)3.23844905
62central nervous system projection neuron axonogenesis (GO:0021952)3.23501444
63transmission of nerve impulse (GO:0019226)3.23392896
64regulation of synaptic plasticity (GO:0048167)3.20020816
65presynaptic membrane assembly (GO:0097105)3.19556131
66regulation of synapse maturation (GO:0090128)3.19388878
67clathrin coat assembly (GO:0048268)3.17835940
68potassium ion import (GO:0010107)3.17773041
69neuronal action potential propagation (GO:0019227)3.16676608
70dendritic spine organization (GO:0097061)3.16507444
71neuronal ion channel clustering (GO:0045161)3.16293847
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.14667536
73gamma-aminobutyric acid transport (GO:0015812)3.14604846
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.12725626
75positive regulation of dendritic spine morphogenesis (GO:0061003)3.11519285
76prepulse inhibition (GO:0060134)3.10474774
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.10346292
78establishment of mitochondrion localization (GO:0051654)3.10262871
79membrane depolarization (GO:0051899)3.07886331
80adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06925015
81regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05722479
82glutamate receptor signaling pathway (GO:0007215)3.05315205
83nucleobase catabolic process (GO:0046113)3.01086536
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.00268131
85response to dietary excess (GO:0002021)2.99495924
86cytoskeletal anchoring at plasma membrane (GO:0007016)2.98657552
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98235560
88neuron-neuron synaptic transmission (GO:0007270)2.97891663
89positive regulation of axon extension (GO:0045773)2.96300125
90neuromuscular synaptic transmission (GO:0007274)2.94314239
91regulation of postsynaptic membrane potential (GO:0060078)2.94029645
92regulation of ARF protein signal transduction (GO:0032012)2.93568883
93postsynaptic membrane organization (GO:0001941)2.93514946
94neurotransmitter transport (GO:0006836)2.93067483
95positive regulation of fibroblast migration (GO:0010763)2.92191504
96regulation of neurotransmitter secretion (GO:0046928)2.92071046
97synaptic vesicle endocytosis (GO:0048488)2.90919695
98cerebellar Purkinje cell differentiation (GO:0021702)2.90413431
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88470506
100cellular sodium ion homeostasis (GO:0006883)2.87873024
101glycine transport (GO:0015816)2.87507457
102regulation of synaptic transmission (GO:0050804)2.86840242
103negative regulation of dendrite morphogenesis (GO:0050774)2.86101744
104axon extension (GO:0048675)2.83706138
105positive regulation of neurotransmitter secretion (GO:0001956)2.82455957
106organelle transport along microtubule (GO:0072384)2.79549180
107axon cargo transport (GO:0008088)2.77266405
108innervation (GO:0060384)2.77177601
109* regulation of dendritic spine development (GO:0060998)2.76493412
110* positive regulation of dendrite development (GO:1900006)2.75053061
111chemosensory behavior (GO:0007635)2.74800425
112regulation of neurotransmitter levels (GO:0001505)2.74600469
113membrane hyperpolarization (GO:0060081)2.74560849
114membrane depolarization during action potential (GO:0086010)2.73572081
115neuromuscular process (GO:0050905)2.73408423
116regulation of vesicle fusion (GO:0031338)2.73230304
117positive regulation of neurotransmitter transport (GO:0051590)2.72979960
118cell communication involved in cardiac conduction (GO:0086065)2.72887685
119vesicle transport along microtubule (GO:0047496)2.72807617
120behavioral defense response (GO:0002209)2.72576855
121behavioral fear response (GO:0001662)2.72576855
122mechanosensory behavior (GO:0007638)2.69411915
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.68754399
124regulation of neurotransmitter transport (GO:0051588)2.68747105
125positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.68636967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.65889500
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.16974614
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94983499
4RNF2_18974828_ChIP-Seq_MESCs_Mouse2.93356561
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.93356561
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89596833
7* RARB_27405468_Chip-Seq_BRAIN_Mouse2.89268283
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.87540507
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.83699699
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75608705
11DROSHA_22980978_ChIP-Seq_HELA_Human2.64326714
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.62993981
13REST_21632747_ChIP-Seq_MESCs_Mouse2.53692728
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47455016
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.44442173
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44071168
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.43938834
18* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.43486722
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41910360
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40987111
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38929239
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.36592052
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.35332042
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.28847618
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23111605
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19978112
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.15533475
28* KDM2B_26808549_Chip-Seq_K562_Human2.05745570
29* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05662709
30ERG_21242973_ChIP-ChIP_JURKAT_Human2.01038218
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90164444
32GBX2_23144817_ChIP-Seq_PC3_Human1.86695422
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.85296476
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.83751317
35* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.81356157
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73664886
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.71369563
38LXR_22292898_ChIP-Seq_THP-1_Human1.64779210
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64673829
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53024762
41RING1B_27294783_Chip-Seq_NPCs_Mouse1.50742771
42KDM2B_26808549_Chip-Seq_DND41_Human1.48847079
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48528585
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46482161
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.46119790
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41545657
47AR_21572438_ChIP-Seq_LNCaP_Human1.40233435
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39885806
49DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.39573901
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34677793
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33768797
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32357097
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.31776440
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30533221
55CTCF_27219007_Chip-Seq_Bcells_Human1.28982166
56ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28809658
57TET1_21490601_ChIP-Seq_MESCs_Mouse1.26521299
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24550245
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.24524971
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.24030331
61RNF2_27304074_Chip-Seq_NSC_Mouse1.14780809
62TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13066406
63SMC4_20622854_ChIP-Seq_HELA_Human1.11788240
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.10672598
65ZNF274_21170338_ChIP-Seq_K562_Hela1.09923231
66AR_19668381_ChIP-Seq_PC3_Human1.09920129
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.09514560
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07893099
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05074048
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01062092
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00975690
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00675786
73CREB1_26743006_Chip-Seq_LNCaP_Human0.99456460
74STAT6_21828071_ChIP-Seq_BEAS2B_Human0.99431159
75SOX2_21211035_ChIP-Seq_LN229_Gbm0.99269397
76NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98385165
77ZNF263_19887448_ChIP-Seq_K562_Human0.97405349
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95216165
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94267288
80* ESR2_21235772_ChIP-Seq_MCF-7_Human0.94184110
81OCT4_19829295_ChIP-Seq_ESCs_Human0.93214789
82KLF4_19829295_ChIP-Seq_ESCs_Human0.91067931
83P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90828977
84CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90308042
85SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89876920
86P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88502375
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.88123467
88* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88039425
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87428201
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87293963
91RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86764191
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86509007
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.86062648
94* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85809134
95TP53_23651856_ChIP-Seq_MEFs_Mouse0.85633253
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.84948671
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.84771115
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.84709897
99TET1_21451524_ChIP-Seq_MESCs_Mouse0.84696471
100SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.81439224
101* P68_20966046_ChIP-Seq_HELA_Human0.81189032
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79945508
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79463224
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.79057979
105AHR_22903824_ChIP-Seq_MCF-7_Human0.77551180
106SOX3_22085726_ChIP-Seq_NPCs_Mouse0.76107604
107VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75619599
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.75436690
109SMAD4_21741376_ChIP-Seq_ESCs_Human0.75350069
110* MYC_27129775_Chip-Seq_CORNEA_Mouse0.75253214
111SA1_27219007_Chip-Seq_ERYTHROID_Human0.74679268
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.73916300
113TCF7_22412390_ChIP-Seq_EML_Mouse0.73794553
114RUNX1_26923725_Chip-Seq_HPCs_Mouse0.73573223
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73534936
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73522544
117NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73008423
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72588797
119SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69900915

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.80062851
2MP0003635_abnormal_synaptic_transmissio3.86659081
3MP0003880_abnormal_central_pattern3.67709286
4MP0004270_analgesia3.53075421
5MP0002063_abnormal_learning/memory/cond3.14412999
6MP0005423_abnormal_somatic_nervous3.10965398
7MP0004858_abnormal_nervous_system2.84191951
8MP0009745_abnormal_behavioral_response2.71686484
9MP0002822_catalepsy2.53831225
10MP0002064_seizures2.49849714
11MP0001968_abnormal_touch/_nociception2.44180094
12MP0002734_abnormal_mechanical_nocicepti2.37114284
13MP0000778_abnormal_nervous_system2.36862063
14MP0002572_abnormal_emotion/affect_behav2.27679817
15MP0009046_muscle_twitch2.19923686
16MP0004811_abnormal_neuron_physiology2.12571227
17MP0009780_abnormal_chondrocyte_physiolo2.12364693
18MP0002733_abnormal_thermal_nociception2.11053076
19MP0001486_abnormal_startle_reflex2.02867885
20MP0002735_abnormal_chemical_nociception1.99980171
21MP0003329_amyloid_beta_deposits1.94658920
22MP0002184_abnormal_innervation1.94506387
23MP0001970_abnormal_pain_threshold1.87049898
24MP0002909_abnormal_adrenal_gland1.85674985
25MP0002272_abnormal_nervous_system1.81729526
26MP0000955_abnormal_spinal_cord1.79647200
27MP0008569_lethality_at_weaning1.75883783
28MP0003122_maternal_imprinting1.71293800
29MP0008961_abnormal_basal_metabolism1.67446923
30MP0000751_myopathy1.63995330
31MP0002736_abnormal_nociception_after1.62845623
32MP0002557_abnormal_social/conspecific_i1.62265284
33MP0001440_abnormal_grooming_behavior1.60153099
34MP0006276_abnormal_autonomic_nervous1.58033594
35MP0002882_abnormal_neuron_morphology1.46282217
36MP0002067_abnormal_sensory_capabilities1.45867273
37MP0000569_abnormal_digit_pigmentation1.44888170
38MP0003690_abnormal_glial_cell1.44653534
39MP0002653_abnormal_ependyma_morphology1.44625939
40MP0005386_behavior/neurological_phenoty1.44334823
41MP0004924_abnormal_behavior1.44334823
42MP0004885_abnormal_endolymph1.41231907
43MP0003283_abnormal_digestive_organ1.40756864
44MP0005623_abnormal_meninges_morphology1.39514712
45MP0001501_abnormal_sleep_pattern1.38643414
46MP0001984_abnormal_olfaction1.38350875
47MP0002152_abnormal_brain_morphology1.30947140
48MP0002066_abnormal_motor_capabilities/c1.29629690
49MP0003879_abnormal_hair_cell1.28275917
50MP0002638_abnormal_pupillary_reflex1.25961852
51MP0000566_synostosis1.24905409
52MP0005645_abnormal_hypothalamus_physiol1.20598319
53MP0005499_abnormal_olfactory_system1.18399019
54MP0005394_taste/olfaction_phenotype1.18399019
55MP0000920_abnormal_myelination1.15715660
56MP0002089_abnormal_postnatal_growth/wei1.14375941
57MP0004233_abnormal_muscle_weight1.13060776
58MP0003633_abnormal_nervous_system1.09658813
59MP0003137_abnormal_impulse_conducting1.07440977
60MP0005670_abnormal_white_adipose1.07166236
61MP0003861_abnormal_nervous_system1.02829109
62MP0005167_abnormal_blood-brain_barrier1.00963186
63MP0002249_abnormal_larynx_morphology0.97988222
64MP0004742_abnormal_vestibular_system0.96408224
65MP0001963_abnormal_hearing_physiology0.96242025
66MP0000013_abnormal_adipose_tissue0.93708223
67MP0003631_nervous_system_phenotype0.93270737
68MP0002069_abnormal_eating/drinking_beha0.92893966
69MP0003787_abnormal_imprinting0.92171533
70MP0000534_abnormal_ureter_morphology0.91687776
71MP0003075_altered_response_to0.90305364
72MP0001529_abnormal_vocalization0.90178705
73MP0005646_abnormal_pituitary_gland0.89184984
74MP0001348_abnormal_lacrimal_gland0.89166877
75MP0004085_abnormal_heartbeat0.88766479
76MP0001502_abnormal_circadian_rhythm0.86542664
77MP0005187_abnormal_penis_morphology0.85257044
78MP0010030_abnormal_orbit_morphology0.85151032
79MP0005551_abnormal_eye_electrophysiolog0.83265466
80MP0003634_abnormal_glial_cell0.82214270
81MP0002229_neurodegeneration0.82150527
82MP0002837_dystrophic_cardiac_calcinosis0.81779642
83MP0001299_abnormal_eye_distance/0.80938532
84MP0004130_abnormal_muscle_cell0.80339739
85MP0000026_abnormal_inner_ear0.79940878
86MP0004145_abnormal_muscle_electrophysio0.77794356
87MP0003705_abnormal_hypodermis_morpholog0.76249074
88MP0003938_abnormal_ear_development0.76170877
89MP0005535_abnormal_body_temperature0.75720329
90MP0000631_abnormal_neuroendocrine_gland0.75240154
91MP0001346_abnormal_lacrimal_gland0.75169431
92MP0001177_atelectasis0.74501118
93MP0001485_abnormal_pinna_reflex0.74184052
94MP0002876_abnormal_thyroid_physiology0.72985123
95MP0002234_abnormal_pharynx_morphology0.72349610
96MP0002752_abnormal_somatic_nervous0.72233230
97MP0003172_abnormal_lysosome_physiology0.72209450
98MP0001188_hyperpigmentation0.71539129
99MP0008874_decreased_physiological_sensi0.69697891
100MP0004142_abnormal_muscle_tone0.68072542
101MP0004215_abnormal_myocardial_fiber0.66969151
102MP0003121_genomic_imprinting0.66906852
103MP0008789_abnormal_olfactory_epithelium0.66575522
104MP0001943_abnormal_respiration0.66093030
105MP0003632_abnormal_nervous_system0.65607580
106MP0005409_darkened_coat_color0.65465784
107MP0003123_paternal_imprinting0.65197371
108MP0002081_perinatal_lethality0.64144948
109MP0001958_emphysema0.63496591
110MP0002751_abnormal_autonomic_nervous0.62864926
111MP0000537_abnormal_urethra_morphology0.61704218
112MP0003119_abnormal_digestive_system0.61600908
113MP0010769_abnormal_survival0.60688461
114MP0000003_abnormal_adipose_tissue0.59708460
115MP0009379_abnormal_foot_pigmentation0.59427019
116MP0001905_abnormal_dopamine_level0.58480327
117MP0000579_abnormal_nail_morphology0.57558481
118MP0000604_amyloidosis0.57245469
119MP0000747_muscle_weakness0.57169270
120MP0004133_heterotaxia0.56464094
121MP0010768_mortality/aging0.56251022
122MP0008770_decreased_survivor_rate0.55711275
123MP0010770_preweaning_lethality0.55569239

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.12958161
2Focal motor seizures (HP:0011153)4.27610111
3Visual hallucinations (HP:0002367)4.20202158
4Focal seizures (HP:0007359)4.16991847
5Ankle clonus (HP:0011448)3.67055821
6Supranuclear gaze palsy (HP:0000605)3.45837150
7Abnormality of the lower motor neuron (HP:0002366)3.42759030
8Papilledema (HP:0001085)3.40734722
9Insomnia (HP:0100785)3.26010657
10Mutism (HP:0002300)3.13916107
11Hyperacusis (HP:0010780)3.13795288
12Action tremor (HP:0002345)3.12361406
13Epileptic encephalopathy (HP:0200134)3.03764461
14Poor eye contact (HP:0000817)2.99432507
15Pointed chin (HP:0000307)2.98569074
16Abnormal eating behavior (HP:0100738)2.97610593
17Amyotrophic lateral sclerosis (HP:0007354)2.89969511
18Torticollis (HP:0000473)2.88709022
19Depression (HP:0000716)2.85327399
20Urinary urgency (HP:0000012)2.81348828
21Megalencephaly (HP:0001355)2.73582936
22Progressive cerebellar ataxia (HP:0002073)2.73475845
23Elfin facies (HP:0004428)2.71455002
24Annular pancreas (HP:0001734)2.68994260
25Impaired social interactions (HP:0000735)2.68770886
26Abnormal social behavior (HP:0012433)2.68770886
27Impaired vibration sensation in the lower limbs (HP:0002166)2.67506519
28Turricephaly (HP:0000262)2.60255187
29Amblyopia (HP:0000646)2.60178305
30Urinary bladder sphincter dysfunction (HP:0002839)2.59086042
31Obstructive sleep apnea (HP:0002870)2.58261233
32Focal dystonia (HP:0004373)2.54973560
33Broad-based gait (HP:0002136)2.53848313
34Intention tremor (HP:0002080)2.46307596
35Renal duplication (HP:0000075)2.44116071
36Akinesia (HP:0002304)2.40668954
37Bronchomalacia (HP:0002780)2.40587487
38Generalized tonic-clonic seizures (HP:0002069)2.39826390
39Aplasia involving bones of the extremities (HP:0009825)2.38682843
40Aplasia involving bones of the upper limbs (HP:0009823)2.38682843
41Aplasia of the phalanges of the hand (HP:0009802)2.38682843
42Polyphagia (HP:0002591)2.37035932
43Epileptiform EEG discharges (HP:0011182)2.37026737
44Craniofacial dystonia (HP:0012179)2.36460937
45Overriding aorta (HP:0002623)2.35894925
46Absence seizures (HP:0002121)2.35753852
47Genetic anticipation (HP:0003743)2.35106363
48Apathy (HP:0000741)2.35001412
49Status epilepticus (HP:0002133)2.33024655
50Atonic seizures (HP:0010819)2.32714696
51Limb dystonia (HP:0002451)2.28087369
52Stereotypic behavior (HP:0000733)2.27489526
53Hemiplegia (HP:0002301)2.26904771
54Insidious onset (HP:0003587)2.22097176
55Termporal pattern (HP:0011008)2.22097176
56Upper limb amyotrophy (HP:0009129)2.21769434
57Distal upper limb amyotrophy (HP:0007149)2.21769434
58Ankyloglossia (HP:0010296)2.19726586
59Anxiety (HP:0000739)2.19376750
60Postural instability (HP:0002172)2.18236494
61Febrile seizures (HP:0002373)2.17816532
62Cerebral hypomyelination (HP:0006808)2.17400983
63Hypoventilation (HP:0002791)2.17253585
64Neoplasm of the heart (HP:0100544)2.16714502
65Diminished motivation (HP:0000745)2.16479031
66Hemiparesis (HP:0001269)2.16137548
67Truncal ataxia (HP:0002078)2.16121024
68Spastic gait (HP:0002064)2.15825757
69Renovascular hypertension (HP:0100817)2.15165223
70Ventricular fibrillation (HP:0001663)2.15139549
71Lower limb amyotrophy (HP:0007210)2.13726633
72Delusions (HP:0000746)2.13723436
73Shallow orbits (HP:0000586)2.13286596
74EEG with generalized epileptiform discharges (HP:0011198)2.11709337
75Dialeptic seizures (HP:0011146)2.08645921
76Peripheral hypomyelination (HP:0007182)2.07912923
77Dysdiadochokinesis (HP:0002075)2.07161177
78Lower limb muscle weakness (HP:0007340)2.07016056
79Cerebral inclusion bodies (HP:0100314)2.05217360
80Bowel diverticulosis (HP:0005222)2.04510935
81Tetraplegia (HP:0002445)2.01954913
82Flat cornea (HP:0007720)2.01324154
83Hypsarrhythmia (HP:0002521)2.01295357
84Spastic tetraparesis (HP:0001285)2.00022029
85Bundle branch block (HP:0011710)1.98037787
86Hand muscle atrophy (HP:0009130)1.96732043
87Failure to thrive in infancy (HP:0001531)1.96659245
88Drooling (HP:0002307)1.94683853
89Excessive salivation (HP:0003781)1.94683853
90Abnormality of the corticospinal tract (HP:0002492)1.93897009
91Impaired smooth pursuit (HP:0007772)1.93490456
92Hyperthyroidism (HP:0000836)1.91270577
93Agitation (HP:0000713)1.89184356
94Spinal canal stenosis (HP:0003416)1.89136674
95Lymphangioma (HP:0100764)1.88330381
96Lower limb asymmetry (HP:0100559)1.87586056
97Rapidly progressive (HP:0003678)1.87553098
98Sacral dimple (HP:0000960)1.86288233
99Dysmetria (HP:0001310)1.85648128
100Bradykinesia (HP:0002067)1.85409693
101Intellectual disability, profound (HP:0002187)1.84702756
102Neurofibrillary tangles (HP:0002185)1.84222503
103Hypercortisolism (HP:0001578)1.83988134
104Generalized hypotonia (HP:0001290)1.83310978
105Hypoplasia of the brainstem (HP:0002365)1.83250534
106Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83250534
107Diplopia (HP:0000651)1.81769522
108Abnormality of binocular vision (HP:0011514)1.81769522
109Sleep apnea (HP:0010535)1.81261282
110Dysmetric saccades (HP:0000641)1.81182976
111Abnormal EKG (HP:0003115)1.80976040
112Bladder diverticulum (HP:0000015)1.80966679
113Fetal akinesia sequence (HP:0001989)1.80822022
114Incomplete penetrance (HP:0003829)1.79171338
115Morphological abnormality of the pyramidal tract (HP:0002062)1.77095778
116Neuronal loss in central nervous system (HP:0002529)1.75009229
117Enlarged penis (HP:0000040)1.74261364
118Clonus (HP:0002169)1.73237167
119Inappropriate behavior (HP:0000719)1.72571172
120Abnormality of the astrocytes (HP:0100707)1.71734939
121Prolonged QT interval (HP:0001657)1.69158662
122Rigidity (HP:0002063)1.67398143
123Split foot (HP:0001839)1.64595042
124Truncus arteriosus (HP:0001660)1.63961513
125Megalocornea (HP:0000485)1.62279721
126Hypoplasia of the corpus callosum (HP:0002079)1.61508328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.45328682
2MAP3K94.01809678
3EPHA43.43446289
4NTRK33.03207697
5MINK12.88413898
6PAK62.55423924
7DAPK22.42467676
8PRKD32.39783556
9CASK2.25055034
10KSR22.23386421
11CAMKK12.19645191
12TRIB32.18605705
13NTRK22.11842957
14MAP3K42.00358526
15KSR11.99597166
16LATS21.98957379
17NTRK11.85498637
18SIK21.75378386
19PHKG21.70651833
20PHKG11.70651833
21TYRO31.57856938
22RIPK11.56081230
23TAOK11.53851887
24CDK51.47830522
25UHMK11.43548974
26DAPK11.41573133
27PINK11.37611201
28PKN21.36348791
29NEK11.34759599
30MAPK131.27700995
31LMTK21.22590067
32MAP2K41.16366766
33DDR21.14603789
34MAP2K71.14259730
35STK381.13485242
36ICK1.12008797
37ALK1.11291450
38CDK181.09282736
39CDK151.07423023
40CDK141.06258519
41PKN11.06061801
42RET1.02527122
43MAPK121.02407849
44CAMK2B1.01104364
45ARAF1.00452649
46MARK20.97203336
47PDGFRA0.96833687
48PAK30.95657397
49CDK11A0.95618626
50GRK50.94073029
51LIMK10.92741732
52SCYL20.92692102
53PRKCG0.92566473
54EPHB20.91145943
55MAP3K120.89357180
56CDK190.88555402
57EEF2K0.83027314
58PRPF4B0.81623765
59STK110.81135624
60ERBB30.80253140
61DYRK20.80182607
62FES0.80180578
63MAP3K20.80074953
64SGK20.79558579
65CAMK10.78831622
66FGFR20.77806878
67RPS6KA20.77446605
68CAMK2G0.77371131
69CAMK1D0.77148349
70PRKCH0.74693227
71MAP3K110.74314574
72CAMKK20.73736556
73RAF10.73116870
74PRKCZ0.70295904
75MAP3K100.69103730
76PLK20.68351683
77DMPK0.67682613
78BRSK10.66337177
79WNK30.65700013
80NEK60.63981272
81CSNK1G20.62328711
82TESK10.58018265
83PTK2B0.57271933
84TIE10.56749493
85DAPK30.55085012
86SGK2230.54960603
87SGK4940.54960603
88CAMK1G0.54926349
89CAMK40.53918542
90CDC42BPA0.51751543
91ERBB20.47951733
92TNIK0.47717887
93PDPK10.47389163
94FYN0.46819422
95BRAF0.46543758
96MAPK40.46136551
97TESK20.45925650
98ROCK10.45452786
99MAP3K70.45069956
100BMX0.44542758
101CAMK2D0.44204038
102WNK40.43629708
103SGK10.43288478
104MAP2K10.43120903
105CAMK2A0.42233983
106PTK20.42227518
107DYRK1A0.41835704
108PDK10.41532738
109RIPK40.40674634
110FER0.40577719
111TNK20.39511440
112ROCK20.39500323
113RPS6KA30.38812805
114SIK30.38689196
115MAPK100.38344178
116MAPK80.37365304
117SGK30.37324132
118ILK0.35177760
119WNK10.33014749
120PRKAA10.32719003
121* PRKCA0.29328773
122PRKG10.29288559

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.84169467
2Olfactory transduction_Homo sapiens_hsa047402.69133994
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.47469109
4Nicotine addiction_Homo sapiens_hsa050332.38861232
5Circadian entrainment_Homo sapiens_hsa047132.36326617
6Long-term potentiation_Homo sapiens_hsa047202.19028850
7GABAergic synapse_Homo sapiens_hsa047272.16212425
8Glutamatergic synapse_Homo sapiens_hsa047242.13427513
9Dopaminergic synapse_Homo sapiens_hsa047282.04011201
10Morphine addiction_Homo sapiens_hsa050322.02895057
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94916995
12Amphetamine addiction_Homo sapiens_hsa050311.89717968
13Cholinergic synapse_Homo sapiens_hsa047251.86309915
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.86055859
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79331868
16Gastric acid secretion_Homo sapiens_hsa049711.74578373
17Salivary secretion_Homo sapiens_hsa049701.74038050
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73988442
19Insulin secretion_Homo sapiens_hsa049111.65588251
20Gap junction_Homo sapiens_hsa045401.64823000
21Axon guidance_Homo sapiens_hsa043601.59391665
22Oxytocin signaling pathway_Homo sapiens_hsa049211.59192466
23Vitamin B6 metabolism_Homo sapiens_hsa007501.53737254
24Cocaine addiction_Homo sapiens_hsa050301.52300525
25Glioma_Homo sapiens_hsa052141.51973405
26GnRH signaling pathway_Homo sapiens_hsa049121.46985264
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42432221
28Renin secretion_Homo sapiens_hsa049241.35661102
29Long-term depression_Homo sapiens_hsa047301.34876865
30Estrogen signaling pathway_Homo sapiens_hsa049151.34394773
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23821400
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23059389
33Melanogenesis_Homo sapiens_hsa049161.20561831
34Calcium signaling pathway_Homo sapiens_hsa040201.18254011
35Taste transduction_Homo sapiens_hsa047421.17887261
36Serotonergic synapse_Homo sapiens_hsa047261.14744223
37ErbB signaling pathway_Homo sapiens_hsa040121.14741598
38cAMP signaling pathway_Homo sapiens_hsa040241.14664839
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.14300293
40Oocyte meiosis_Homo sapiens_hsa041141.13040738
41Type II diabetes mellitus_Homo sapiens_hsa049301.10962592
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10783225
43Endometrial cancer_Homo sapiens_hsa052131.10281158
44VEGF signaling pathway_Homo sapiens_hsa043701.08932453
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.05641495
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05520615
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02375001
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02249757
49Dilated cardiomyopathy_Homo sapiens_hsa054140.99901987
50mTOR signaling pathway_Homo sapiens_hsa041500.99275425
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96688424
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96326983
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94505994
54Non-small cell lung cancer_Homo sapiens_hsa052230.90861146
55Dorso-ventral axis formation_Homo sapiens_hsa043200.90554932
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89286569
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88251811
58Colorectal cancer_Homo sapiens_hsa052100.87616431
59Choline metabolism in cancer_Homo sapiens_hsa052310.86022445
60Rap1 signaling pathway_Homo sapiens_hsa040150.81569314
61Phototransduction_Homo sapiens_hsa047440.80554895
62Renal cell carcinoma_Homo sapiens_hsa052110.79114717
63Cardiac muscle contraction_Homo sapiens_hsa042600.79079417
64Endocytosis_Homo sapiens_hsa041440.78566524
65Insulin signaling pathway_Homo sapiens_hsa049100.78328286
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.76557302
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.75239011
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74287841
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73404234
70MAPK signaling pathway_Homo sapiens_hsa040100.72880913
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71789971
72Thyroid hormone synthesis_Homo sapiens_hsa049180.71569393
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71142283
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71070986
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69537662
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69351105
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68947268
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68630827
79Nitrogen metabolism_Homo sapiens_hsa009100.68454264
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.68140747
81Hippo signaling pathway_Homo sapiens_hsa043900.67539557
82Wnt signaling pathway_Homo sapiens_hsa043100.65058005
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63364441
84Ras signaling pathway_Homo sapiens_hsa040140.63057467
85Glucagon signaling pathway_Homo sapiens_hsa049220.62734721
86Hedgehog signaling pathway_Homo sapiens_hsa043400.62286406
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61772511
88Alcoholism_Homo sapiens_hsa050340.61667200
89Chronic myeloid leukemia_Homo sapiens_hsa052200.61205490
90Arginine and proline metabolism_Homo sapiens_hsa003300.60364441
91Collecting duct acid secretion_Homo sapiens_hsa049660.59709092
92Fatty acid biosynthesis_Homo sapiens_hsa000610.57607809
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55177971
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54523982
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52623173
96Basal cell carcinoma_Homo sapiens_hsa052170.52135883
97Ovarian steroidogenesis_Homo sapiens_hsa049130.52112606
98Proteoglycans in cancer_Homo sapiens_hsa052050.51983391
99Vibrio cholerae infection_Homo sapiens_hsa051100.51850191
100AMPK signaling pathway_Homo sapiens_hsa041520.51288052
101Inositol phosphate metabolism_Homo sapiens_hsa005620.49878048
102Focal adhesion_Homo sapiens_hsa045100.49173997
103Pancreatic secretion_Homo sapiens_hsa049720.48927262
104Bladder cancer_Homo sapiens_hsa052190.48296250
105Notch signaling pathway_Homo sapiens_hsa043300.48140106
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48070337
107Tight junction_Homo sapiens_hsa045300.47100475
108Arginine biosynthesis_Homo sapiens_hsa002200.46558080
109Histidine metabolism_Homo sapiens_hsa003400.45482182
110PPAR signaling pathway_Homo sapiens_hsa033200.44674910
111beta-Alanine metabolism_Homo sapiens_hsa004100.43789625
112Bile secretion_Homo sapiens_hsa049760.42618576
113Prion diseases_Homo sapiens_hsa050200.42428196
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41119003
115Chemokine signaling pathway_Homo sapiens_hsa040620.40799732
116Glycerolipid metabolism_Homo sapiens_hsa005610.39211716
117Protein digestion and absorption_Homo sapiens_hsa049740.32191286
118ECM-receptor interaction_Homo sapiens_hsa045120.31777294
119Alzheimers disease_Homo sapiens_hsa050100.29921599

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