PAM16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.12671428
2energy coupled proton transport, down electrochemical gradient (GO:0015985)7.86944852
3ATP synthesis coupled proton transport (GO:0015986)7.86944852
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.41840380
5respiratory electron transport chain (GO:0022904)6.43036292
6electron transport chain (GO:0022900)6.29959313
7chaperone-mediated protein transport (GO:0072321)5.89122081
8ribosomal small subunit biogenesis (GO:0042274)5.75557134
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.53484100
10protein neddylation (GO:0045116)5.30656042
11viral transcription (GO:0019083)5.25613729
12mitochondrial respiratory chain complex I assembly (GO:0032981)5.19589087
13NADH dehydrogenase complex assembly (GO:0010257)5.19589087
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.19589087
15protein complex biogenesis (GO:0070271)5.17597817
16translational termination (GO:0006415)5.08519099
17cotranslational protein targeting to membrane (GO:0006613)4.76582851
18mitochondrial respiratory chain complex assembly (GO:0033108)4.73215108
19GTP biosynthetic process (GO:0006183)4.72565820
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.69848964
21proteasome assembly (GO:0043248)4.68337936
22protein targeting to ER (GO:0045047)4.66743446
23protein localization to endoplasmic reticulum (GO:0070972)4.46487879
24establishment of protein localization to endoplasmic reticulum (GO:0072599)4.46422296
25purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.25168382
26translational elongation (GO:0006414)4.24905812
27ribosomal small subunit assembly (GO:0000028)4.24704484
28pseudouridine synthesis (GO:0001522)4.23432953
29cellular protein complex disassembly (GO:0043624)4.15742011
30purine nucleoside triphosphate biosynthetic process (GO:0009145)4.14317864
31hydrogen ion transmembrane transport (GO:1902600)4.13147469
32ATP biosynthetic process (GO:0006754)4.11626256
33termination of RNA polymerase III transcription (GO:0006386)4.11203538
34transcription elongation from RNA polymerase III promoter (GO:0006385)4.11203538
35maturation of SSU-rRNA (GO:0030490)4.08361722
36viral life cycle (GO:0019058)4.04835091
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.03804559
38UTP biosynthetic process (GO:0006228)4.03063734
39inner mitochondrial membrane organization (GO:0007007)3.96768814
40regulation of mitochondrial translation (GO:0070129)3.96603978
41respiratory chain complex IV assembly (GO:0008535)3.92011844
42translation (GO:0006412)3.89119066
43guanosine-containing compound biosynthetic process (GO:1901070)3.87901911
44translational initiation (GO:0006413)3.76844484
45* protein targeting to mitochondrion (GO:0006626)3.75928425
46ribonucleoside triphosphate biosynthetic process (GO:0009201)3.75651538
47* establishment of protein localization to mitochondrion (GO:0072655)3.74879796
48DNA deamination (GO:0045006)3.73379804
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.72637936
50cullin deneddylation (GO:0010388)3.69937252
51ribosomal large subunit biogenesis (GO:0042273)3.69860094
52spliceosomal snRNP assembly (GO:0000387)3.68587215
53proton transport (GO:0015992)3.68076220
54exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.65711305
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62002252
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60491978
57rRNA processing (GO:0006364)3.60259580
58dopamine transport (GO:0015872)3.59075902
597-methylguanosine mRNA capping (GO:0006370)3.58800457
60hydrogen transport (GO:0006818)3.58525640
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.56892543
62regulation of cellular amino acid metabolic process (GO:0006521)3.56603720
63RNA capping (GO:0036260)3.55560678
647-methylguanosine RNA capping (GO:0009452)3.55560678
65establishment of integrated proviral latency (GO:0075713)3.53991096
66oxidative phosphorylation (GO:0006119)3.51671489
67cytochrome complex assembly (GO:0017004)3.49681940
68rRNA metabolic process (GO:0016072)3.46039696
69protein complex disassembly (GO:0043241)3.45562266
70protein deneddylation (GO:0000338)3.44569601
71* protein localization to mitochondrion (GO:0070585)3.43884949
72RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37304229
73tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37304229
74cellular component biogenesis (GO:0044085)3.37089480
75UTP metabolic process (GO:0046051)3.35431401
76chromatin remodeling at centromere (GO:0031055)3.34747529
77negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33428529
78negative regulation of ligase activity (GO:0051352)3.33428529
79CTP metabolic process (GO:0046036)3.33401075
80CTP biosynthetic process (GO:0006241)3.33401075
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.31588273
82rRNA methylation (GO:0031167)3.31337643
83macromolecular complex disassembly (GO:0032984)3.30607347
84nucleoside triphosphate biosynthetic process (GO:0009142)3.29875437
85CENP-A containing nucleosome assembly (GO:0034080)3.29725537
86DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25611376
87positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.23179599
88base-excision repair, AP site formation (GO:0006285)3.22663781
89DNA replication checkpoint (GO:0000076)3.20778987
90transcription from mitochondrial promoter (GO:0006390)3.18409002
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17651284
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17178611
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17178611
94peptidyl-histidine modification (GO:0018202)3.15757206
95purine nucleobase biosynthetic process (GO:0009113)3.15697843
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.14794075
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.14794075
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.14794075
99establishment of viral latency (GO:0019043)3.12827236
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.12105849
101maturation of 5.8S rRNA (GO:0000460)3.10762082
102telomere maintenance via semi-conservative replication (GO:0032201)3.10264687
103nucleoside diphosphate phosphorylation (GO:0006165)3.09838744
104protein targeting to membrane (GO:0006612)3.08591858
105deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.08082425
106regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.07745556
107kinetochore assembly (GO:0051382)3.06591524
108pyrimidine nucleotide catabolic process (GO:0006244)3.05232843
109signal transduction involved in DNA integrity checkpoint (GO:0072401)3.04831518
110signal transduction involved in DNA damage checkpoint (GO:0072422)3.04831518
111protein-cofactor linkage (GO:0018065)3.04222481
112positive regulation of ligase activity (GO:0051351)3.04156269
113ribonucleoprotein complex biogenesis (GO:0022613)3.04086397
114tRNA processing (GO:0008033)3.03879481
115ribosome biogenesis (GO:0042254)3.02996322
116signal transduction involved in cell cycle checkpoint (GO:0072395)3.02184868
117rRNA modification (GO:0000154)3.00842746
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99981533
119transcription elongation from RNA polymerase I promoter (GO:0006362)2.96871086
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95290522
121* mitochondrial transport (GO:0006839)2.95150062
122energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93068034
123ATP hydrolysis coupled proton transport (GO:0015991)2.93068034
124regulation of oxidative phosphorylation (GO:0002082)2.92364167
125pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.91710529
126regulation of cellular amine metabolic process (GO:0033238)2.91037590
127pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.89153207
128L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85694316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.02023854
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.42927949
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.19430599
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.89369701
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.79533002
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.70312653
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.68690401
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.55868841
9E2F7_22180533_ChIP-Seq_HELA_Human3.50182121
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.41709817
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.23995092
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.00494774
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.90563484
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.88532151
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87240382
16EZH2_22144423_ChIP-Seq_EOC_Human2.79648461
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44716457
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32571153
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28131419
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21231764
21YY1_21170310_ChIP-Seq_MESCs_Mouse2.14579136
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.14275590
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.12738373
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09713282
25VDR_23849224_ChIP-Seq_CD4+_Human2.05163280
26DCP1A_22483619_ChIP-Seq_HELA_Human1.97828331
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88967275
28VDR_22108803_ChIP-Seq_LS180_Human1.88672062
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86325919
30MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85081774
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80901831
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.80686529
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76888041
34XRN2_22483619_ChIP-Seq_HELA_Human1.74264483
35TTF2_22483619_ChIP-Seq_HELA_Human1.73826722
36TAF15_26573619_Chip-Seq_HEK293_Human1.68343270
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.66991634
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63585823
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.62471779
40ELK1_19687146_ChIP-ChIP_HELA_Human1.61781745
41KDM5A_27292631_Chip-Seq_BREAST_Human1.61760930
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60746938
43FOXP3_21729870_ChIP-Seq_TREG_Human1.55808094
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54342187
45IRF1_19129219_ChIP-ChIP_H3396_Human1.52858677
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52117127
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46400016
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.41662056
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41498403
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40886069
51GABP_19822575_ChIP-Seq_HepG2_Human1.40578567
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.40172414
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39390805
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36050897
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34302064
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.31765626
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30835071
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30782275
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30360037
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28342475
61FUS_26573619_Chip-Seq_HEK293_Human1.28305627
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.25573637
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24405379
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.24399443
65ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24168604
66BP1_19119308_ChIP-ChIP_Hs578T_Human1.19790021
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19585271
68POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19268365
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17544252
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.15395768
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15211981
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.14620458
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13393769
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13296765
75FOXP1_21924763_ChIP-Seq_HESCs_Human1.12774065
76GBX2_23144817_ChIP-Seq_PC3_Human1.11848021
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11794708
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08421876
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08165538
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07384017
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.06735377
82MYC_18940864_ChIP-ChIP_HL60_Human1.06460399
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06286650
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05592747
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03963118
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02622819
87CIITA_25753668_ChIP-Seq_RAJI_Human1.00631651
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00428482
89REST_21632747_ChIP-Seq_MESCs_Mouse0.97258507
90HOXB4_20404135_ChIP-ChIP_EML_Mouse0.95974618
91JARID2_20064375_ChIP-Seq_MESCs_Mouse0.95472789
92ER_23166858_ChIP-Seq_MCF-7_Human0.95461471
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95048757
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94486014
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93540692
96RNF2_27304074_Chip-Seq_NSC_Mouse0.93525558
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91770517
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88566730
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87136534
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.86929953
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86783156
102IGF1R_20145208_ChIP-Seq_DFB_Human0.86150097
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85836418
104NOTCH1_21737748_ChIP-Seq_TLL_Human0.85761614
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85036563
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84869281
107KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84768683
108FLI1_27457419_Chip-Seq_LIVER_Mouse0.84213976
109EED_16625203_ChIP-ChIP_MESCs_Mouse0.82852930
110CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82706030
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82304716
112TET1_21451524_ChIP-Seq_MESCs_Mouse0.81759396
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81297646
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.81119331
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80135175
116TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.79871711
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79842847
118ZNF263_19887448_ChIP-Seq_K562_Human0.79701813
119TFEB_21752829_ChIP-Seq_HELA_Human0.78683195
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78583671
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.78468194
122TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78298534
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.78068401
124JARID2_20075857_ChIP-Seq_MESCs_Mouse0.76729278
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.76722607
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76017057
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75377831
128CTCF_26484167_Chip-Seq_Bcells_Mouse0.75164719
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.74794656
130REST_18959480_ChIP-ChIP_MESCs_Mouse0.74695480
131SOX17_20123909_ChIP-Seq_XEN_Mouse0.74505049
132ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73817587
133ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73501168
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.73373317
135CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73032896
136TP53_22573176_ChIP-Seq_HFKS_Human0.72793605
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.72743817
138ZNF274_21170338_ChIP-Seq_K562_Hela0.72499918
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72200444
140P300_19829295_ChIP-Seq_ESCs_Human0.72045112
141RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69849682
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.69778069

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.04970719
2MP0001529_abnormal_vocalization3.96488369
3MP0003880_abnormal_central_pattern3.93062296
4MP0003806_abnormal_nucleotide_metabolis3.50752699
5MP0010094_abnormal_chromosome_stability3.37118708
6MP0006276_abnormal_autonomic_nervous3.30119859
7MP0001905_abnormal_dopamine_level3.05361377
8MP0003111_abnormal_nucleus_morphology2.95593839
9MP0003077_abnormal_cell_cycle2.50730659
10MP0001188_hyperpigmentation2.38267262
11MP0003136_yellow_coat_color2.30608623
12MP0002837_dystrophic_cardiac_calcinosis2.30177830
13MP0002638_abnormal_pupillary_reflex2.07121063
14MP0004142_abnormal_muscle_tone2.06451104
15MP0002736_abnormal_nociception_after2.04088330
16MP0005423_abnormal_somatic_nervous2.03022666
17MP0006292_abnormal_olfactory_placode2.00253862
18MP0001968_abnormal_touch/_nociception1.98943212
19MP0002272_abnormal_nervous_system1.98592662
20MP0002735_abnormal_chemical_nociception1.95235608
21MP0008007_abnormal_cellular_replicative1.92211949
22MP0006036_abnormal_mitochondrial_physio1.86915354
23MP0003122_maternal_imprinting1.84425759
24MP0009745_abnormal_behavioral_response1.82423352
25MP0001440_abnormal_grooming_behavior1.81986780
26MP0009046_muscle_twitch1.73619540
27MP0001764_abnormal_homeostasis1.73508608
28MP0002064_seizures1.73164544
29MP0002572_abnormal_emotion/affect_behav1.71705900
30MP0006035_abnormal_mitochondrial_morpho1.71475206
31MP0002160_abnormal_reproductive_system1.68003738
32MP0002734_abnormal_mechanical_nocicepti1.67872870
33MP0004145_abnormal_muscle_electrophysio1.64699518
34MP0002163_abnormal_gland_morphology1.64444026
35MP0003693_abnormal_embryo_hatching1.62390715
36MP0003718_maternal_effect1.60485237
37MP0003635_abnormal_synaptic_transmissio1.57109006
38MP0001984_abnormal_olfaction1.54962429
39MP0001970_abnormal_pain_threshold1.54291721
40MP0002210_abnormal_sex_determination1.54268824
41MP0006072_abnormal_retinal_apoptosis1.54216625
42MP0001986_abnormal_taste_sensitivity1.53448459
43MP0008875_abnormal_xenobiotic_pharmacok1.52575861
44MP0003646_muscle_fatigue1.47768938
45MP0005410_abnormal_fertilization1.44377042
46MP0004270_analgesia1.43817256
47MP0009697_abnormal_copulation1.43520117
48MP0005409_darkened_coat_color1.43439469
49MP0005379_endocrine/exocrine_gland_phen1.41720777
50MP0002733_abnormal_thermal_nociception1.41210833
51MP0002102_abnormal_ear_morphology1.40631279
52MP0002184_abnormal_innervation1.39419216
53MP0001501_abnormal_sleep_pattern1.38218416
54MP0008057_abnormal_DNA_replication1.37390369
55MP0000358_abnormal_cell_content/1.37329135
56MP0002063_abnormal_learning/memory/cond1.37155919
57MP0008789_abnormal_olfactory_epithelium1.36879700
58MP0001486_abnormal_startle_reflex1.36634714
59MP0000751_myopathy1.36232227
60MP0001929_abnormal_gametogenesis1.36121597
61MP0002234_abnormal_pharynx_morphology1.35814724
62MP0005645_abnormal_hypothalamus_physiol1.35301479
63MP0004742_abnormal_vestibular_system1.34724730
64MP0002067_abnormal_sensory_capabilities1.33577809
65MP0010030_abnormal_orbit_morphology1.27322118
66MP0004147_increased_porphyrin_level1.25374557
67MP0002938_white_spotting1.25299842
68MP0001145_abnormal_male_reproductive1.23865442
69MP0005332_abnormal_amino_acid1.23200634
70MP0005075_abnormal_melanosome_morpholog1.19656243
71MP0000778_abnormal_nervous_system1.19107077
72MP0005646_abnormal_pituitary_gland1.18639966
73MP0002751_abnormal_autonomic_nervous1.17797168
74MP0000653_abnormal_sex_gland1.17282514
75MP0005389_reproductive_system_phenotype1.15509489
76MP0005394_taste/olfaction_phenotype1.14030027
77MP0005499_abnormal_olfactory_system1.14030027
78MP0004924_abnormal_behavior1.12488105
79MP0005386_behavior/neurological_phenoty1.12488105
80MP0004859_abnormal_synaptic_plasticity1.09770441
81MP0003315_abnormal_perineum_morphology1.08182413
82MP0001485_abnormal_pinna_reflex1.08059665
83MP0008877_abnormal_DNA_methylation1.06014793
84MP0001727_abnormal_embryo_implantation1.05716220
85MP0000372_irregular_coat_pigmentation1.05615572
86MP0008932_abnormal_embryonic_tissue1.04964712
87MP0004215_abnormal_myocardial_fiber1.04381779
88MP0002876_abnormal_thyroid_physiology1.04042385
89MP0000313_abnormal_cell_death1.03908491
90MP0005083_abnormal_biliary_tract1.03387329
91MP0003011_delayed_dark_adaptation1.02869299
92MP0000631_abnormal_neuroendocrine_gland1.01958153
93MP0003186_abnormal_redox_activity1.01599949
94MP0003786_premature_aging1.01239164
95MP0002557_abnormal_social/conspecific_i1.00632434
96MP0004133_heterotaxia0.98968063
97MP0005551_abnormal_eye_electrophysiolog0.97432672
98MP0001293_anophthalmia0.96721983
99MP0008872_abnormal_physiological_respon0.96714413
100MP0001963_abnormal_hearing_physiology0.96688803
101MP0009333_abnormal_splenocyte_physiolog0.96651658
102MP0002752_abnormal_somatic_nervous0.96605932
103MP0000026_abnormal_inner_ear0.95257053
104MP0001697_abnormal_embryo_size0.94685426
105MP0003567_abnormal_fetal_cardiomyocyte0.93008418
106MP0008995_early_reproductive_senescence0.89914780
107MP0003121_genomic_imprinting0.89437029
108MP0000350_abnormal_cell_proliferation0.88970244
109MP0003137_abnormal_impulse_conducting0.88905312
110MP0010386_abnormal_urinary_bladder0.88875284
111MP0004036_abnormal_muscle_relaxation0.88618621
112MP0002066_abnormal_motor_capabilities/c0.87971810
113MP0001730_embryonic_growth_arrest0.87085532
114MP0005266_abnormal_metabolism0.84386806
115MP0005253_abnormal_eye_physiology0.83161148
116MP0002882_abnormal_neuron_morphology0.83150773
117MP0002822_catalepsy0.82411181
118MP0000749_muscle_degeneration0.82048893
119MP0005636_abnormal_mineral_homeostasis0.81625604
120MP0002229_neurodegeneration0.81215310
121MP0003938_abnormal_ear_development0.81077205
122MP0000750_abnormal_muscle_regeneration0.79221639
123MP0004957_abnormal_blastocyst_morpholog0.78919162
124MP0002332_abnormal_exercise_endurance0.78087375
125MP0002019_abnormal_tumor_incidence0.77715936
126MP0003698_abnormal_male_reproductive0.77356341
127MP0000049_abnormal_middle_ear0.76399717
128MP0005670_abnormal_white_adipose0.76140291
129MP0001502_abnormal_circadian_rhythm0.75552529
130MP0003123_paternal_imprinting0.74678135
131MP0002161_abnormal_fertility/fecundity0.74364645
132MP0002277_abnormal_respiratory_mucosa0.73825090
133MP0002080_prenatal_lethality0.73759962
134MP0002132_abnormal_respiratory_system0.72551160
135MP0001881_abnormal_mammary_gland0.72119182
136MP0001119_abnormal_female_reproductive0.71921713
137MP0005084_abnormal_gallbladder_morpholo0.71829525
138MP0008058_abnormal_DNA_repair0.70756777
139MP0003879_abnormal_hair_cell0.70755747
140MP0008873_increased_physiological_sensi0.69852166
141MP0005360_urolithiasis0.68514073
142MP0001661_extended_life_span0.68476267
143MP0001919_abnormal_reproductive_system0.66100724
144MP0002095_abnormal_skin_pigmentation0.64099566
145MP0001873_stomach_inflammation0.63773539
146MP0002085_abnormal_embryonic_tissue0.62052628
147MP0002653_abnormal_ependyma_morphology0.60922228

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.01865100
2Abnormal mitochondria in muscle tissue (HP:0008316)6.22211859
3Mitochondrial inheritance (HP:0001427)6.14632347
4Progressive macrocephaly (HP:0004481)5.78589921
5Acute encephalopathy (HP:0006846)5.52531320
6Increased CSF lactate (HP:0002490)5.13814922
7Hepatocellular necrosis (HP:0001404)5.12598612
8Increased hepatocellular lipid droplets (HP:0006565)4.97660376
9Renal Fanconi syndrome (HP:0001994)4.44755233
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.32138430
11Abnormality of cells of the erythroid lineage (HP:0012130)4.27500334
12Lipid accumulation in hepatocytes (HP:0006561)4.26147359
13Hepatic necrosis (HP:0002605)4.25245798
14Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.14038845
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.86598350
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.86598350
173-Methylglutaconic aciduria (HP:0003535)3.85024752
18Cerebral edema (HP:0002181)3.73998374
19Increased intramyocellular lipid droplets (HP:0012240)3.69826273
20Exercise intolerance (HP:0003546)3.68263143
21Optic disc pallor (HP:0000543)3.67791731
22Abnormal number of erythroid precursors (HP:0012131)3.66578796
23Respiratory failure (HP:0002878)3.58219201
24Leukodystrophy (HP:0002415)3.48698736
25Increased serum pyruvate (HP:0003542)3.46112722
26Abnormality of glycolysis (HP:0004366)3.46112722
27Lactic acidosis (HP:0003128)3.43845547
28Exertional dyspnea (HP:0002875)3.28172432
29Increased serum lactate (HP:0002151)3.27933742
30Macrocytic anemia (HP:0001972)2.98440448
31Increased muscle lipid content (HP:0009058)2.96513807
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.95284580
33Respiratory difficulties (HP:0002880)2.95152569
34Abnormality of renal resorption (HP:0011038)2.88456063
35Myokymia (HP:0002411)2.81946488
36Reticulocytopenia (HP:0001896)2.76699346
37Generalized aminoaciduria (HP:0002909)2.55149885
38Aplastic anemia (HP:0001915)2.48361389
39Pallor (HP:0000980)2.44201797
40Testicular atrophy (HP:0000029)2.41341241
41Cerebral hypomyelination (HP:0006808)2.38279482
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38069013
43Abnormality of alanine metabolism (HP:0010916)2.38069013
44Hyperalaninemia (HP:0003348)2.38069013
45Hypothermia (HP:0002045)2.34753095
46X-linked dominant inheritance (HP:0001423)2.30379429
47Colon cancer (HP:0003003)2.28807181
48Methylmalonic aciduria (HP:0012120)2.28344041
49Abnormal respiratory epithelium morphology (HP:0012253)2.27731094
50Abnormal respiratory motile cilium morphology (HP:0005938)2.27731094
51Medial flaring of the eyebrow (HP:0010747)2.27657136
52Emotional lability (HP:0000712)2.27487631
53Abnormal protein glycosylation (HP:0012346)2.25433500
54Abnormal glycosylation (HP:0012345)2.25433500
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.25433500
56Abnormal protein N-linked glycosylation (HP:0012347)2.25433500
57CNS demyelination (HP:0007305)2.22535198
58Absent/shortened dynein arms (HP:0200106)2.21433778
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.21433778
60Limb dystonia (HP:0002451)2.20468733
61Microvesicular hepatic steatosis (HP:0001414)2.20128184
62Parakeratosis (HP:0001036)2.19948247
63Hyperphosphaturia (HP:0003109)2.18482919
64Retinal dysplasia (HP:0007973)2.16505474
65Abnormal ciliary motility (HP:0012262)2.14246522
66Methylmalonic acidemia (HP:0002912)2.13924559
67Progressive muscle weakness (HP:0003323)2.12833051
68Absent thumb (HP:0009777)2.12799001
69Pancytopenia (HP:0001876)2.12562333
70Progressive microcephaly (HP:0000253)2.11391629
71Dicarboxylic aciduria (HP:0003215)2.09015815
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09015815
73Meckel diverticulum (HP:0002245)2.07641705
74Degeneration of anterior horn cells (HP:0002398)2.07410068
75Abnormality of the anterior horn cell (HP:0006802)2.07410068
76Neuroendocrine neoplasm (HP:0100634)2.06702385
77Poor suck (HP:0002033)2.06310249
78Gait imbalance (HP:0002141)2.03713348
79Reduced antithrombin III activity (HP:0001976)2.03647720
80Delusions (HP:0000746)2.02996365
81Hyperglycinemia (HP:0002154)2.00400712
82Abnormal hair whorl (HP:0010721)1.98857641
83Abnormality of the preputium (HP:0100587)1.97869187
84Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96610207
85Microretrognathia (HP:0000308)1.96028187
86Congenital ichthyosiform erythroderma (HP:0007431)1.95640846
87Abnormality of the ileum (HP:0001549)1.95018143
88Congenital primary aphakia (HP:0007707)1.94631240
89Multiple enchondromatosis (HP:0005701)1.93152771
90Cleft eyelid (HP:0000625)1.91435049
91Abnormality of the labia minora (HP:0012880)1.90702190
92Pheochromocytoma (HP:0002666)1.89541072
93Oral leukoplakia (HP:0002745)1.88700387
94Abnormality of secondary sexual hair (HP:0009888)1.88036134
95Abnormality of the axillary hair (HP:0100134)1.88036134
96Abnormal respiratory motile cilium physiology (HP:0012261)1.87681035
97Focal motor seizures (HP:0011153)1.86155896
98Nephrogenic diabetes insipidus (HP:0009806)1.86071293
99Sensory axonal neuropathy (HP:0003390)1.85709595
100Aplasia/Hypoplasia of the uvula (HP:0010293)1.85637335
101Glycosuria (HP:0003076)1.83779807
102Abnormality of urine glucose concentration (HP:0011016)1.83779807
103Lethargy (HP:0001254)1.83495909
104Horseshoe kidney (HP:0000085)1.83408716
105Pancreatic fibrosis (HP:0100732)1.82897628
106Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81908305
107Type I transferrin isoform profile (HP:0003642)1.79409760
108Abnormality of serum amino acid levels (HP:0003112)1.77599473
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77253176
110Abnormal urine phosphate concentration (HP:0012599)1.76174075
111Molar tooth sign on MRI (HP:0002419)1.75768016
112Abnormality of midbrain morphology (HP:0002418)1.75768016
113Esotropia (HP:0000565)1.75548040
114Abnormal pupillary function (HP:0007686)1.75527207
115Rough bone trabeculation (HP:0100670)1.75063498
116Opisthotonus (HP:0002179)1.74617016
117Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71069979
118Aplasia/hypoplasia of the uterus (HP:0008684)1.71000416
119Progressive external ophthalmoplegia (HP:0000590)1.69371212
120Genital tract atresia (HP:0001827)1.69150964
121Blindness (HP:0000618)1.68861819
122Renal tubular dysfunction (HP:0000124)1.68743228
123Vaginal atresia (HP:0000148)1.68264169
124Abnormality of methionine metabolism (HP:0010901)1.68192530
125Abnormality of the pons (HP:0007361)1.67880620
126Vomiting (HP:0002013)1.67475737
127Hypoplasia of the pons (HP:0012110)1.67408061
128Polyphagia (HP:0002591)1.66243907
129Chromsome breakage (HP:0040012)1.66140270
130Abnormality of placental membranes (HP:0011409)1.64855457
131Amniotic constriction ring (HP:0009775)1.64855457
132Pancreatic cysts (HP:0001737)1.64465900
133Sclerocornea (HP:0000647)1.64009193
134Gliosis (HP:0002171)1.62978344
135Ragged-red muscle fibers (HP:0003200)1.61867212
136Sparse eyelashes (HP:0000653)1.61632111
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.59851950
138Stenosis of the external auditory canal (HP:0000402)1.59643832
139Concave nail (HP:0001598)1.55723397
140Irregular epiphyses (HP:0010582)1.54189600
141Myotonia (HP:0002486)1.53993259
142Short tibia (HP:0005736)1.53836528
143Atonic seizures (HP:0010819)1.53680924
144True hermaphroditism (HP:0010459)1.51175507
145Congenital malformation of the right heart (HP:0011723)1.48272664
146Double outlet right ventricle (HP:0001719)1.48272664
147Hyperventilation (HP:0002883)1.47325660
148Rhinitis (HP:0012384)1.46324665
149Muscle hypertrophy of the lower extremities (HP:0008968)1.46286509

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.32975165
2NME23.41068084
3STK163.33129750
4NME13.06462978
5ARAF2.98712570
6BUB12.96537255
7CASK2.82544327
8NEK12.67908522
9GRK52.63514233
10CDC72.55405416
11PNCK2.25205527
12MAP3K122.22169823
13NUAK11.90503557
14STK391.87455136
15TNIK1.84758275
16GRK71.84571522
17PDK21.78510901
18VRK11.78176508
19MYLK1.72610973
20BRAF1.70852941
21MUSK1.70513266
22PIM21.66217804
23DYRK21.60118517
24BMPR1B1.58916168
25LIMK11.56602074
26BCR1.52719842
27TTK1.50752973
28ADRBK21.44636746
29WEE11.41179035
30MST41.40924838
31MAPK131.39258227
32MAP4K21.33990172
33PLK11.33453484
34EIF2AK31.32602053
35OXSR11.31668214
36MARK11.26541387
37SRPK11.24292925
38CDK191.21958802
39MAP2K71.21358100
40WNK31.20994803
41MAPKAPK51.20820611
42UHMK11.18767780
43TLK11.16828751
44TRIM281.16583764
45DYRK31.15527818
46CSNK1G31.15415366
47WNK41.13718475
48OBSCN1.10019388
49BMPR21.08901394
50PLK21.08077473
51CAMK2B1.05398116
52PBK1.04411222
53PLK41.04363542
54ATR1.04132754
55TSSK61.02154631
56CHEK20.98911143
57DAPK10.98044321
58NEK20.96396298
59NTRK30.95983618
60AURKB0.92602577
61SIK30.88355307
62ADRBK10.88047387
63CAMK2A0.87175528
64EIF2AK10.87001644
65BRSK10.86566628
66FGR0.81748862
67TAF10.79558475
68CAMK2D0.78996628
69PKN10.77183438
70GRK10.75985855
71TESK20.73783618
72CAMK2G0.73572333
73STK40.73158895
74PAK40.72289691
75CDK80.72260885
76CDK70.70528352
77EPHA40.70049593
78NTRK20.68962124
79KDR0.68530269
80MOS0.68212411
81AURKA0.66677215
82BCKDK0.66331324
83ILK0.65695029
84BRSK20.65552646
85MKNK10.65530507
86ABL20.65479521
87PRKCI0.63937901
88CDK140.61971031
89RPS6KA50.60805981
90PASK0.60403680
91PLK30.59573331
92CSNK1G20.59352439
93PRKCE0.59087479
94CCNB10.59074918
95CSNK1G10.58748729
96PRKCG0.58220462
97PAK10.57948197
98CSNK2A20.57830432
99IRAK20.57539651
100CDK180.57199235
101AKT30.56520073
102CSNK2A10.56236119
103CHEK10.55062428
104ROCK20.54763560
105CDK11A0.53994088
106PDK30.53964657
107PDK40.53964657
108CDK150.53115685
109MAP3K110.52926363
110DAPK30.52920569
111LRRK20.50699901
112TESK10.50639535
113PRKACA0.49644194
114ZAK0.49630345
115PHKG20.49338672
116PHKG10.49338672
117MINK10.48660740
118ATM0.47696303
119MAP3K40.47391134
120MKNK20.45797623
121FES0.43781014
122MAPK40.42686806
123RAF10.42064410
124EIF2AK20.41926201
125CDK50.41245015
126CSNK1A1L0.40566322
127FLT30.39442813
128CDK30.39423797
129DYRK1A0.38940211
130CSNK1E0.37835409
131PINK10.37134700
132PTK2B0.36833851
133IKBKB0.34798813
134MAP3K80.33978523
135INSRR0.32974455
136RPS6KB20.32038122
137CDK10.31003311
138CSNK1A10.30091426
139CDK20.29416739
140AKT20.29063086
141RPS6KA40.28178036
142TNK20.25640348

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001906.01066819
2Parkinsons disease_Homo sapiens_hsa050125.14247839
3Ribosome_Homo sapiens_hsa030104.96447307
4Proteasome_Homo sapiens_hsa030504.00095097
5Alzheimers disease_Homo sapiens_hsa050103.83763867
6Huntingtons disease_Homo sapiens_hsa050163.75254225
7RNA polymerase_Homo sapiens_hsa030203.24899475
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.02705579
9Protein export_Homo sapiens_hsa030602.89857980
10Cardiac muscle contraction_Homo sapiens_hsa042602.62301179
11Collecting duct acid secretion_Homo sapiens_hsa049661.91953751
12Pyrimidine metabolism_Homo sapiens_hsa002401.76028367
13One carbon pool by folate_Homo sapiens_hsa006701.75722345
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68576222
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64815716
16Nicotine addiction_Homo sapiens_hsa050331.51447082
17Spliceosome_Homo sapiens_hsa030401.46818829
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44378661
19Fatty acid elongation_Homo sapiens_hsa000621.40068936
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32694270
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29694589
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27506604
23Basal transcription factors_Homo sapiens_hsa030221.24856231
24Vibrio cholerae infection_Homo sapiens_hsa051101.19610154
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.18275604
26Purine metabolism_Homo sapiens_hsa002301.17323704
27Nucleotide excision repair_Homo sapiens_hsa034201.12941136
28SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97154040
29Synaptic vesicle cycle_Homo sapiens_hsa047210.91011189
30Biosynthesis of amino acids_Homo sapiens_hsa012300.90672148
31Cell cycle_Homo sapiens_hsa041100.89739741
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89235840
33Serotonergic synapse_Homo sapiens_hsa047260.88912771
34Mismatch repair_Homo sapiens_hsa034300.87801129
35Sulfur metabolism_Homo sapiens_hsa009200.86759162
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86659204
37RNA transport_Homo sapiens_hsa030130.86566522
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.86095291
39Homologous recombination_Homo sapiens_hsa034400.85669857
40DNA replication_Homo sapiens_hsa030300.84411596
41Carbon metabolism_Homo sapiens_hsa012000.84335737
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82326655
43Metabolic pathways_Homo sapiens_hsa011000.82283612
44Phototransduction_Homo sapiens_hsa047440.81229834
45RNA degradation_Homo sapiens_hsa030180.79655048
46Taste transduction_Homo sapiens_hsa047420.77829335
47Regulation of autophagy_Homo sapiens_hsa041400.76416001
48Rheumatoid arthritis_Homo sapiens_hsa053230.75936931
49Ether lipid metabolism_Homo sapiens_hsa005650.75895640
50Selenocompound metabolism_Homo sapiens_hsa004500.75551673
51Peroxisome_Homo sapiens_hsa041460.70026395
52Glutathione metabolism_Homo sapiens_hsa004800.69262073
53GABAergic synapse_Homo sapiens_hsa047270.69161892
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67446791
55Arachidonic acid metabolism_Homo sapiens_hsa005900.66250958
56Steroid biosynthesis_Homo sapiens_hsa001000.65519029
57Pyruvate metabolism_Homo sapiens_hsa006200.63449974
58Vitamin B6 metabolism_Homo sapiens_hsa007500.62660643
59Sulfur relay system_Homo sapiens_hsa041220.61109754
60Non-homologous end-joining_Homo sapiens_hsa034500.60421150
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.58613858
62Base excision repair_Homo sapiens_hsa034100.58570627
63mRNA surveillance pathway_Homo sapiens_hsa030150.57126328
64Linoleic acid metabolism_Homo sapiens_hsa005910.54448050
65Morphine addiction_Homo sapiens_hsa050320.51912626
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50833180
67Fructose and mannose metabolism_Homo sapiens_hsa000510.49673778
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.48353133
69Glutamatergic synapse_Homo sapiens_hsa047240.47735750
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47593420
71Fanconi anemia pathway_Homo sapiens_hsa034600.47108062
72Amphetamine addiction_Homo sapiens_hsa050310.46767702
73Pentose phosphate pathway_Homo sapiens_hsa000300.44122294
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43259986
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41663303
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41292074
77N-Glycan biosynthesis_Homo sapiens_hsa005100.39940566
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38555603
79Phagosome_Homo sapiens_hsa041450.38446832
80Tyrosine metabolism_Homo sapiens_hsa003500.37859953
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37347568
82Folate biosynthesis_Homo sapiens_hsa007900.36803796
83Dopaminergic synapse_Homo sapiens_hsa047280.35514659
84p53 signaling pathway_Homo sapiens_hsa041150.35490722
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35332553
86Alcoholism_Homo sapiens_hsa050340.34439395
87Circadian entrainment_Homo sapiens_hsa047130.34250375
88Long-term depression_Homo sapiens_hsa047300.33832880
89Epstein-Barr virus infection_Homo sapiens_hsa051690.33524718
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33170889
91Tryptophan metabolism_Homo sapiens_hsa003800.32273701
92Caffeine metabolism_Homo sapiens_hsa002320.31812106
93Chemical carcinogenesis_Homo sapiens_hsa052040.31281705
94Arginine and proline metabolism_Homo sapiens_hsa003300.30797767
95Cocaine addiction_Homo sapiens_hsa050300.30308305
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29782704
97Autoimmune thyroid disease_Homo sapiens_hsa053200.29481975
98Galactose metabolism_Homo sapiens_hsa000520.29275679
99Butanoate metabolism_Homo sapiens_hsa006500.28795694
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.28329257
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27813378
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27572803
103Sphingolipid metabolism_Homo sapiens_hsa006000.26538277
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.25816171
105Calcium signaling pathway_Homo sapiens_hsa040200.25648900
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25435415
107Arginine biosynthesis_Homo sapiens_hsa002200.25363466
108Vitamin digestion and absorption_Homo sapiens_hsa049770.25140778
109Long-term potentiation_Homo sapiens_hsa047200.23834874
110Oocyte meiosis_Homo sapiens_hsa041140.23612500
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.23408822
112Graft-versus-host disease_Homo sapiens_hsa053320.23003734
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22815056
114Fatty acid metabolism_Homo sapiens_hsa012120.22317491
115Fatty acid degradation_Homo sapiens_hsa000710.22039699
116Phenylalanine metabolism_Homo sapiens_hsa003600.21867379
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.21280271
118beta-Alanine metabolism_Homo sapiens_hsa004100.20093394
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19617080
120Asthma_Homo sapiens_hsa053100.19548946
121Nitrogen metabolism_Homo sapiens_hsa009100.18610631
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18069581
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18059359
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17991172
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17485995
126Systemic lupus erythematosus_Homo sapiens_hsa053220.17358274
127Cholinergic synapse_Homo sapiens_hsa047250.16905372
128Propanoate metabolism_Homo sapiens_hsa006400.16092531
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.15135177
130Allograft rejection_Homo sapiens_hsa053300.15108612
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14993233
132Type I diabetes mellitus_Homo sapiens_hsa049400.14517781
133Olfactory transduction_Homo sapiens_hsa047400.13179956
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12452449
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11540109
136Gap junction_Homo sapiens_hsa045400.11335668
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10945944
138Retinol metabolism_Homo sapiens_hsa008300.09641607

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