PAN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K9 demethylation (GO:0033169)7.91732085
2histone H3-K36 demethylation (GO:0070544)7.81380178
3histone lysine demethylation (GO:0070076)5.07325621
4synaptonemal complex assembly (GO:0007130)5.01709504
5negative regulation of erythrocyte differentiation (GO:0045647)4.90995027
6histone demethylation (GO:0016577)4.85776619
7chromosome organization involved in meiosis (GO:0070192)4.83774382
8synapsis (GO:0007129)4.73680715
9signal complex assembly (GO:0007172)4.67410258
10negative regulation of histone methylation (GO:0031061)4.56246128
11DNA methylation involved in gamete generation (GO:0043046)4.56127552
12DNA synthesis involved in DNA repair (GO:0000731)4.48709930
13mitotic chromosome condensation (GO:0007076)4.42775178
14piRNA metabolic process (GO:0034587)4.31231710
15protein demethylation (GO:0006482)4.27134181
16protein dealkylation (GO:0008214)4.27134181
17mannose metabolic process (GO:0006013)4.22787154
18pre-miRNA processing (GO:0031054)4.21464447
19nuclear pore organization (GO:0006999)4.21045468
20synaptonemal complex organization (GO:0070193)4.20900086
21protein localization to kinetochore (GO:0034501)4.17668638
22nuclear pore complex assembly (GO:0051292)4.11133707
23histone H4 deacetylation (GO:0070933)4.02938264
24male meiosis I (GO:0007141)3.97049994
25mitotic nuclear envelope disassembly (GO:0007077)3.96383690
26histone H4-K16 acetylation (GO:0043984)3.94934236
27male meiosis (GO:0007140)3.90013732
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89522379
29growth hormone receptor signaling pathway (GO:0060396)3.84373118
30protein localization to chromosome, centromeric region (GO:0071459)3.81456481
31mitotic metaphase plate congression (GO:0007080)3.79874404
32mitotic sister chromatid cohesion (GO:0007064)3.77847147
33regulation of sister chromatid cohesion (GO:0007063)3.73184922
34positive regulation of gene expression, epigenetic (GO:0045815)3.71076157
35membrane disassembly (GO:0030397)3.70950969
36nuclear envelope disassembly (GO:0051081)3.70950969
37meiotic nuclear division (GO:0007126)3.67224053
38regulation of NFAT protein import into nucleus (GO:0051532)3.60164342
39poly(A)+ mRNA export from nucleus (GO:0016973)3.60014767
40sister chromatid cohesion (GO:0007062)3.59513014
41regulation of ARF protein signal transduction (GO:0032012)3.57789060
42mitotic sister chromatid segregation (GO:0000070)3.56731413
43sister chromatid segregation (GO:0000819)3.56516434
44DNA unwinding involved in DNA replication (GO:0006268)3.56135851
45regulation of ARF GTPase activity (GO:0032312)3.52775512
46regulation of spindle organization (GO:0090224)3.47992417
47folic acid-containing compound biosynthetic process (GO:0009396)3.45069839
48positive regulation of gamma-delta T cell activation (GO:0046645)3.44483629
49regulation of nucleobase-containing compound transport (GO:0032239)3.41996887
50cellular response to growth hormone stimulus (GO:0071378)3.41899954
51gene silencing by RNA (GO:0031047)3.40354224
52negative regulation of cell size (GO:0045792)3.39262724
53histone H2A monoubiquitination (GO:0035518)3.38740278
54positive regulation of chromosome segregation (GO:0051984)3.37041364
55regulation of mitotic spindle organization (GO:0060236)3.33116403
56metaphase plate congression (GO:0051310)3.32048339
57histone H3 deacetylation (GO:0070932)3.31004897
58regulation of histone H3-K9 methylation (GO:0051570)3.30547068
59establishment of nucleus localization (GO:0040023)3.28238184
60histone H4-K8 acetylation (GO:0043982)3.28120244
61histone H4-K5 acetylation (GO:0043981)3.28120244
62dosage compensation (GO:0007549)3.25016285
63regulation of histone H3-K27 methylation (GO:0061085)3.24171340
64protein localization to chromosome (GO:0034502)3.20169839
65positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.18923868
66regulation of chromatin binding (GO:0035561)3.18490342
67DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.16757492
68regulation of histone methylation (GO:0031060)3.15083016
69attachment of spindle microtubules to kinetochore (GO:0008608)3.14022926
70paraxial mesoderm development (GO:0048339)3.11844644
71nuclear envelope organization (GO:0006998)3.11160376
72histone H3-K9 modification (GO:0061647)3.11093518
73negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.07603845
74regulation of gamma-delta T cell differentiation (GO:0045586)3.06850815
75gene silencing (GO:0016458)3.06121086
76regulation of hippo signaling (GO:0035330)3.05942535
77histone H3-K4 trimethylation (GO:0080182)3.05302000
78DNA replication-dependent nucleosome organization (GO:0034723)3.04594927
79DNA replication-dependent nucleosome assembly (GO:0006335)3.04594927
80meiosis I (GO:0007127)3.04242406
81DNA duplex unwinding (GO:0032508)3.03497854
82peptidyl-lysine trimethylation (GO:0018023)3.02383265
83DNA geometric change (GO:0032392)3.01538663
84DNA damage response, signal transduction resulting in transcription (GO:0042772)3.01462551
85histone deubiquitination (GO:0016578)2.96624451
86macroautophagy (GO:0016236)2.95874744
87regulation of chromosome segregation (GO:0051983)2.93327394
88definitive hemopoiesis (GO:0060216)2.90483990
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88085762
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.88085762
91regulation of gene silencing by RNA (GO:0060966)2.87948884
92regulation of posttranscriptional gene silencing (GO:0060147)2.87948884
93regulation of gene silencing by miRNA (GO:0060964)2.87948884
94pore complex assembly (GO:0046931)2.87568680
95histone H4-K12 acetylation (GO:0043983)2.87449850
96B cell receptor signaling pathway (GO:0050853)2.87443904
97establishment of chromosome localization (GO:0051303)2.85428359
98regulation of gamma-delta T cell activation (GO:0046643)2.84756083
99regulation of translational fidelity (GO:0006450)2.84447854
100DNA methylation (GO:0006306)2.84434029
101DNA alkylation (GO:0006305)2.84434029
102histone lysine methylation (GO:0034968)2.83104405
103positive regulation of mitotic sister chromatid separation (GO:1901970)2.82726606
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.82726606
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.82726606
106regulation of transcription from RNA polymerase I promoter (GO:0006356)2.81613983
107meiotic chromosome segregation (GO:0045132)2.80540951
108positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.79597150
109regulation of telomere maintenance via telomerase (GO:0032210)2.79254147
110regulation of RNA export from nucleus (GO:0046831)2.78972575
111glucocorticoid receptor signaling pathway (GO:0042921)2.77180345
112mRNA stabilization (GO:0048255)2.76880723
113RNA stabilization (GO:0043489)2.76880723
114heterochromatin organization (GO:0070828)2.75440083
115mating behavior (GO:0007617)2.75324364
116histone H4 acetylation (GO:0043967)2.75293224
117chromosome condensation (GO:0030261)2.75186029
118chromatin assembly or disassembly (GO:0006333)2.75161449
119regulation of DNA damage checkpoint (GO:2000001)2.74904017
120peptidyl-lysine methylation (GO:0018022)2.74416424
121intracellular estrogen receptor signaling pathway (GO:0030520)2.73370039
122negative regulation of gene silencing (GO:0060969)2.73162061
123peptidyl-lysine dimethylation (GO:0018027)2.72889892
124histone H2A acetylation (GO:0043968)2.72566284
125monoubiquitinated protein deubiquitination (GO:0035520)2.72228192
126glycine metabolic process (GO:0006544)2.70705510
127genitalia morphogenesis (GO:0035112)2.70694967
128kinetochore organization (GO:0051383)2.70086859
129negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.68629483
130DNA conformation change (GO:0071103)2.68574199
131negative regulation of inclusion body assembly (GO:0090084)2.67449216
132positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.66824159
133negative regulation of chromosome segregation (GO:0051985)2.66047834
134ATP-dependent chromatin remodeling (GO:0043044)2.65973844
135mRNA transport (GO:0051028)2.65392747
136positive regulation of Rap GTPase activity (GO:0032854)2.65026075
137negative regulation of histone modification (GO:0031057)2.64542748
138regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.64458281
139chromosome segregation (GO:0007059)2.64120560
140negative regulation of mRNA processing (GO:0050686)2.64071664
141DNA replication checkpoint (GO:0000076)2.63553591
142negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.62645849
143DNA replication-independent nucleosome assembly (GO:0006336)2.61426489
144DNA replication-independent nucleosome organization (GO:0034724)2.61426489
145mitotic spindle assembly checkpoint (GO:0007094)2.60524444
146cytoplasmic mRNA processing body assembly (GO:0033962)2.59773250
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.59586314
148spindle assembly checkpoint (GO:0071173)2.58779809
149DNA packaging (GO:0006323)2.58293706
150histone H3-K9 methylation (GO:0051567)2.58091624
151spindle checkpoint (GO:0031577)2.58001932
152positive regulation of response to oxidative stress (GO:1902884)2.57351275
153positive regulation of cellular response to oxidative stress (GO:1900409)2.57351275
154thymic T cell selection (GO:0045061)2.57144244
155nucleus localization (GO:0051647)2.56978457
156positive regulation of granulocyte differentiation (GO:0030854)2.56832271
157negative regulation of RNA splicing (GO:0033119)2.56304431
158regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.56237865
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.55969754
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55969754
161negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55969754
162negative regulation of sister chromatid segregation (GO:0033046)2.55969754
163one-carbon metabolic process (GO:0006730)2.55655087
164mitotic spindle checkpoint (GO:0071174)2.53659236
1653-UTR-mediated mRNA stabilization (GO:0070935)2.53433944
166regulation of mitotic metaphase/anaphase transition (GO:0030071)2.53384494
167regulation of histone H3-K4 methylation (GO:0051569)2.53295184
168Peyers patch development (GO:0048541)2.52618697
169mucosal-associated lymphoid tissue development (GO:0048537)2.52618697
170negative regulation of mRNA metabolic process (GO:1903312)2.52506795
171folic acid metabolic process (GO:0046655)2.52126157
172positive thymic T cell selection (GO:0045059)2.51368729
173histone H3-K4 methylation (GO:0051568)2.51143337
174histone deacetylation (GO:0016575)2.51104498
175translesion synthesis (GO:0019985)2.51076729
176cellular response to reactive nitrogen species (GO:1902170)2.48362100
177insulin-like growth factor receptor signaling pathway (GO:0048009)2.47353928
178regulation of fatty acid beta-oxidation (GO:0031998)2.47221815
179positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.46811021
180protein-DNA complex disassembly (GO:0032986)2.45756120
181nucleosome disassembly (GO:0006337)2.45756120
182embryonic process involved in female pregnancy (GO:0060136)2.44392657
183interkinetic nuclear migration (GO:0022027)2.42837254
184body morphogenesis (GO:0010171)2.42142043
185positive regulation of histone deacetylation (GO:0031065)2.41944015
186negative regulation of fatty acid biosynthetic process (GO:0045717)2.41533197
187COPII vesicle coating (GO:0048208)2.40988530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.98695826
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.66436555
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.25739887
4MYC_22102868_ChIP-Seq_BL_Human3.24178810
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23097475
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.65072508
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60974274
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.38670293
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30631259
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.29103504
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28853276
12AR_21909140_ChIP-Seq_LNCAP_Human2.26855579
13LXR_22292898_ChIP-Seq_THP-1_Human2.13128033
14CIITA_25753668_ChIP-Seq_RAJI_Human2.12380309
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11215345
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.11065903
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.03462083
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02390923
19E2F1_21310950_ChIP-Seq_MCF-7_Human1.99455289
20MAF_26560356_Chip-Seq_TH2_Human1.99395715
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.98495976
22SMC4_20622854_ChIP-Seq_HELA_Human1.93811109
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.86480868
24KDM2B_26808549_Chip-Seq_K562_Human1.82463390
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.76782318
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.76558086
27KDM2B_26808549_Chip-Seq_JURKAT_Human1.76376543
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.75653034
29CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74876543
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73549278
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71636596
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.69011802
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67557358
34RACK7_27058665_Chip-Seq_MCF-7_Human1.66139636
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61878146
36KDM5A_27292631_Chip-Seq_BREAST_Human1.61629607
37TCF7_22412390_ChIP-Seq_EML_Mouse1.60759618
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58737703
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58342506
40CREB1_26743006_Chip-Seq_LNCaP_Human1.57560359
41* XRN2_22483619_ChIP-Seq_HELA_Human1.56954538
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.55273044
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.54657881
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52837941
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52447718
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51903014
47* VDR_24763502_ChIP-Seq_THP-1_Human1.51530609
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49148066
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49089057
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.48675832
51SCL_19346495_ChIP-Seq_HPC-7_Human1.48191843
52* VDR_21846776_ChIP-Seq_THP-1_Human1.47912342
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.47005005
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46895919
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45741089
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45537959
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44814815
58RUNX_20019798_ChIP-Seq_JUKART_Human1.42549710
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41325702
60MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38258981
61IRF8_22096565_ChIP-ChIP_GC-B_Human1.38247157
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38026554
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.37950299
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.37800510
65NANOG_21062744_ChIP-ChIP_HESCs_Human1.36835808
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36340408
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31323339
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31127009
69UTX_26944678_Chip-Seq_JUKART_Human1.30522259
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.29228821
71GATA1_19941826_ChIP-Seq_K562_Human1.28999518
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28460830
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28442969
74* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27777609
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27375417
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27329027
77KDM2B_26808549_Chip-Seq_DND41_Human1.26611630
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23342433
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.22983723
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22898989
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22776706
82SPI1_23127762_ChIP-Seq_K562_Human1.22561371
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21675922
84BCOR_27268052_Chip-Seq_Bcells_Human1.21235404
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20668626
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19440004
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18830395
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18053300
89TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17915294
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17895947
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16649461
92LXR_22158963_ChIP-Seq_LIVER_Mouse1.16624582
93* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16577599
94CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16008385
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13899974
96NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13807418
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13384261
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13292183
99KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11258155
100ZNF263_19887448_ChIP-Seq_K562_Human1.10471132
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10463058
102CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09433434
103FOXP3_21729870_ChIP-Seq_TREG_Human1.09183199
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08964981
105MAF_26560356_Chip-Seq_TH1_Human1.08862066
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07409337
107GABP_19822575_ChIP-Seq_HepG2_Human1.06217073
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05844207
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05791673
110CHD1_26751641_Chip-Seq_LNCaP_Human1.05448871
111SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04995571
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04837335
113SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04728928
114* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04490726
115PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04282470
116NCOR1_26117541_ChIP-Seq_K562_Human1.03604971
117FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03532729
118MYB_26560356_Chip-Seq_TH2_Human1.03459999
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.03341267
120RARB_27405468_Chip-Seq_BRAIN_Mouse1.02673573
121MYB_26560356_Chip-Seq_TH1_Human1.02580313
122* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02349104
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02071423
124DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01172098
125CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00956778
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00281234
127* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99514994
128* ELK3_25401928_ChIP-Seq_HUVEC_Human0.99038846
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98044200
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97882041
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97442234
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.96798809
133POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95773099
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95718998
135ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94872930
136ATF3_27146783_Chip-Seq_COLON_Human0.93856065
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93703789
138TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93149451
139CLOCK_20551151_ChIP-Seq_293T_Human0.92967244
140* GATA6_25053715_ChIP-Seq_YYC3_Human0.92934511
141KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92048620
142KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92048620
143KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92048620
144TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91733457
145CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90562224
146ZFP281_18757296_ChIP-ChIP_E14_Mouse0.89303323
147NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89138304
148E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88908963
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87605363
150KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86963395
151SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86679646
152TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.85406284
153EST1_17652178_ChIP-ChIP_JURKAT_Human0.84327663
154FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82952477
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82529914
156P68_20966046_ChIP-Seq_HELA_Human0.82258995
157ETS1_20019798_ChIP-Seq_JURKAT_Human0.82111802
158TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81210066
159TFEB_21752829_ChIP-Seq_HELA_Human0.80581887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color4.14313305
2MP0003172_abnormal_lysosome_physiology3.38125557
3MP0003111_abnormal_nucleus_morphology3.28991122
4MP0003693_abnormal_embryo_hatching3.19052282
5MP0002009_preneoplasia3.17882194
6MP0010094_abnormal_chromosome_stability3.16651025
7MP0002653_abnormal_ependyma_morphology3.13129418
8MP0003077_abnormal_cell_cycle2.81833372
9MP0004957_abnormal_blastocyst_morpholog2.60700708
10MP0003705_abnormal_hypodermis_morpholog2.43431428
11MP0005365_abnormal_bile_salt2.29217693
12MP0008260_abnormal_autophagy2.26215727
13MP0008057_abnormal_DNA_replication2.22780257
14MP0002139_abnormal_hepatobiliary_system2.22433325
15MP0010030_abnormal_orbit_morphology2.20026150
16MP0001730_embryonic_growth_arrest2.13712754
17MP0005666_abnormal_adipose_tissue2.11528017
18MP0008877_abnormal_DNA_methylation2.02824951
19MP0005360_urolithiasis2.01903200
20MP0002132_abnormal_respiratory_system1.99611675
21MP0010352_gastrointestinal_tract_polyps1.92746290
22MP0000678_abnormal_parathyroid_gland1.89467195
23MP0005058_abnormal_lysosome_morphology1.87649573
24MP0008058_abnormal_DNA_repair1.85348096
25MP0005380_embryogenesis_phenotype1.85003995
26MP0001672_abnormal_embryogenesis/_devel1.85003995
27MP0000350_abnormal_cell_proliferation1.83841834
28MP0003984_embryonic_growth_retardation1.80031415
29MP0002088_abnormal_embryonic_growth/wei1.77199132
30MP0004381_abnormal_hair_follicle1.73504651
31MP0003698_abnormal_male_reproductive1.72327668
32MP0003123_paternal_imprinting1.71444792
33MP0005085_abnormal_gallbladder_physiolo1.67955878
34MP0000383_abnormal_hair_follicle1.66983469
35MP0002084_abnormal_developmental_patter1.65644707
36MP0001697_abnormal_embryo_size1.65201497
37MP0003806_abnormal_nucleotide_metabolis1.64318569
38MP0005076_abnormal_cell_differentiation1.63945714
39MP0004264_abnormal_extraembryonic_tissu1.63855143
40MP0003436_decreased_susceptibility_to1.61705304
41MP0003890_abnormal_embryonic-extraembry1.59336264
42MP0002085_abnormal_embryonic_tissue1.58361928
43MP0002086_abnormal_extraembryonic_tissu1.57267503
44MP0010678_abnormal_skin_adnexa1.54742100
45MP0003121_genomic_imprinting1.53070314
46MP0004197_abnormal_fetal_growth/weight/1.52909760
47MP0008007_abnormal_cellular_replicative1.50314672
48MP0003943_abnormal_hepatobiliary_system1.48825081
49MP0003690_abnormal_glial_cell1.48304221
50MP0005375_adipose_tissue_phenotype1.47420213
51MP0000003_abnormal_adipose_tissue1.41930949
52MP0003300_gastrointestinal_ulcer1.41333949
53MP0002080_prenatal_lethality1.41295723
54MP0009672_abnormal_birth_weight1.40710473
55MP0003656_abnormal_erythrocyte_physiolo1.40141087
56MP0001661_extended_life_span1.37788078
57MP0002971_abnormal_brown_adipose1.32472663
58MP0001915_intracranial_hemorrhage1.31678989
59MP0003252_abnormal_bile_duct1.30399300
60MP0010234_abnormal_vibrissa_follicle1.30377120
61MP0002089_abnormal_postnatal_growth/wei1.29440866
62MP0002166_altered_tumor_susceptibility1.26935302
63MP0002396_abnormal_hematopoietic_system1.25725783
64MP0008932_abnormal_embryonic_tissue1.25033203
65MP0000015_abnormal_ear_pigmentation1.22573562
66MP0005397_hematopoietic_system_phenotyp1.18314956
67MP0001545_abnormal_hematopoietic_system1.18314956
68MP0003567_abnormal_fetal_cardiomyocyte1.17888171
69MP0010307_abnormal_tumor_latency1.17365966
70MP0003115_abnormal_respiratory_system1.16252297
71MP0003119_abnormal_digestive_system1.14931103
72MP0009053_abnormal_anal_canal1.13926265
73MP0001849_ear_inflammation1.12364885
74MP0002970_abnormal_white_adipose1.12333893
75MP0002722_abnormal_immune_system1.10520629
76MP0009115_abnormal_fat_cell1.10125468
77MP0003763_abnormal_thymus_physiology1.09432511
78MP0008789_abnormal_olfactory_epithelium1.08316937
79MP0003718_maternal_effect1.07215667
80MP0001800_abnormal_humoral_immune1.06819687
81MP0002019_abnormal_tumor_incidence1.05596906
82MP0009703_decreased_birth_body1.05484078
83MP0002822_catalepsy1.04486295
84MP0002210_abnormal_sex_determination1.03216341
85MP0000609_abnormal_liver_physiology1.02866372
86MP0008995_early_reproductive_senescence1.02811060
87MP0009278_abnormal_bone_marrow1.02640164
88MP0001293_anophthalmia1.02181311
89MP0008961_abnormal_basal_metabolism1.00864824
90MP0004036_abnormal_muscle_relaxation1.00664917
91MP0005310_abnormal_salivary_gland1.00475037
92MP0003183_abnormal_peptide_metabolism0.99227769
93MP0000703_abnormal_thymus_morphology0.97918824
94MP0000313_abnormal_cell_death0.97448918
95MP0001929_abnormal_gametogenesis0.96908592
96MP0004233_abnormal_muscle_weight0.96446701
97MP0004808_abnormal_hematopoietic_stem0.95987344
98MP0005451_abnormal_body_composition0.95885290
99MP0010329_abnormal_lipoprotein_level0.94137207
100MP0000537_abnormal_urethra_morphology0.93355904
101MP0001119_abnormal_female_reproductive0.93187717
102MP0003453_abnormal_keratinocyte_physiol0.92960251
103MP0005499_abnormal_olfactory_system0.92279822
104MP0005394_taste/olfaction_phenotype0.92279822
105MP0003699_abnormal_female_reproductive0.91616127
106MP0002092_abnormal_eye_morphology0.91514385
107MP0003787_abnormal_imprinting0.91369118
108MP0005621_abnormal_cell_physiology0.91009815
109MP0001666_abnormal_nutrient_absorption0.90762498
110MP0000689_abnormal_spleen_morphology0.90474236
111MP0000566_synostosis0.89930611
112MP0000653_abnormal_sex_gland0.89370599
113MP0002161_abnormal_fertility/fecundity0.89326968
114MP0003935_abnormal_craniofacial_develop0.89008681
115MP0003868_abnormal_feces_composition0.88438252
116MP0001145_abnormal_male_reproductive0.88333122
117MP0009840_abnormal_foam_cell0.86965476
118MP0004185_abnormal_adipocyte_glucose0.85407012
119MP0003937_abnormal_limbs/digits/tail_de0.84500627
120MP0002925_abnormal_cardiovascular_devel0.84343782
121MP0006054_spinal_hemorrhage0.84032967
122MP0002269_muscular_atrophy0.83621160
123MP0000685_abnormal_immune_system0.82052019
124MP0002249_abnormal_larynx_morphology0.81942355
125MP0004947_skin_inflammation0.81616048
126MP0005023_abnormal_wound_healing0.81405190
127MP0000428_abnormal_craniofacial_morphol0.80976659
128MP0000598_abnormal_liver_morphology0.78930682
129MP0001873_stomach_inflammation0.78692302
130MP0006072_abnormal_retinal_apoptosis0.78069656
131MP0005220_abnormal_exocrine_pancreas0.77773431
132MP0005187_abnormal_penis_morphology0.77622550
133MP0000716_abnormal_immune_system0.77305861
134MP0001502_abnormal_circadian_rhythm0.77217631
135MP0002932_abnormal_joint_morphology0.76175339
136MP0003786_premature_aging0.76110685
137MP0000427_abnormal_hair_cycle0.75646279
138MP0003566_abnormal_cell_adhesion0.74421923
139MP0000013_abnormal_adipose_tissue0.73588978
140MP0010630_abnormal_cardiac_muscle0.73511282
141MP0001835_abnormal_antigen_presentation0.73236003
142MP0000490_abnormal_crypts_of0.72249471
143MP0002420_abnormal_adaptive_immunity0.72074010
144MP0010155_abnormal_intestine_physiology0.71899666
145MP0000733_abnormal_muscle_development0.71635417
146MP0000377_abnormal_hair_follicle0.71166439
147MP0001819_abnormal_immune_cell0.70580270
148MP0003303_peritoneal_inflammation0.70301304
149MP0002075_abnormal_coat/hair_pigmentati0.70027312
150MP0001790_abnormal_immune_system0.69881041
151MP0000569_abnormal_digit_pigmentation0.69597099
152MP0002398_abnormal_bone_marrow0.69585968
153MP0001286_abnormal_eye_development0.68853187
154MP0002697_abnormal_eye_size0.68637942

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.53841981
2Ependymoma (HP:0002888)3.40853496
3Increased nuchal translucency (HP:0010880)3.07674701
4Heterotopia (HP:0002282)3.02762217
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.99319859
611 pairs of ribs (HP:0000878)2.91864500
7Colitis (HP:0002583)2.80495702
8Reticulocytosis (HP:0001923)2.79235906
9Medulloblastoma (HP:0002885)2.77920554
10Pendular nystagmus (HP:0012043)2.77373731
11Macroorchidism (HP:0000053)2.75190142
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70981346
13Short 4th metacarpal (HP:0010044)2.70981346
14Patellar aplasia (HP:0006443)2.68556222
15Deep venous thrombosis (HP:0002625)2.63994061
16Pseudobulbar signs (HP:0002200)2.59719342
17Exercise-induced myalgia (HP:0003738)2.57182266
18Hyperacusis (HP:0010780)2.54723133
19Long eyelashes (HP:0000527)2.54456118
20Progressive external ophthalmoplegia (HP:0000590)2.53407497
21Chorioretinal atrophy (HP:0000533)2.51873791
22Neoplasm of the oral cavity (HP:0100649)2.49539886
23Renovascular hypertension (HP:0100817)2.48903399
24Gastrointestinal inflammation (HP:0004386)2.47111018
25Aplasia/Hypoplasia of the patella (HP:0006498)2.44258435
26Ankyloglossia (HP:0010296)2.40157519
27Dislocated radial head (HP:0003083)2.40016957
28Bowel incontinence (HP:0002607)2.39796214
29Truncal obesity (HP:0001956)2.38741086
30Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.36766459
31Neonatal hypoglycemia (HP:0001998)2.35768883
32Volvulus (HP:0002580)2.33737479
33Hemorrhage of the eye (HP:0011885)2.32953797
34Abnormality of the intervertebral disk (HP:0005108)2.32480390
35Neoplasm of striated muscle (HP:0009728)2.32463799
36Rhabdomyosarcoma (HP:0002859)2.32338951
37Cholecystitis (HP:0001082)2.30813056
38Abnormal gallbladder physiology (HP:0012438)2.30813056
39Tubulointerstitial nephritis (HP:0001970)2.29840894
40Malignant gastrointestinal tract tumors (HP:0006749)2.29212770
41Gastrointestinal carcinoma (HP:0002672)2.29212770
42Horizontal nystagmus (HP:0000666)2.28188787
43Astrocytoma (HP:0009592)2.24162122
44Abnormality of the astrocytes (HP:0100707)2.24162122
45Anal stenosis (HP:0002025)2.23431975
46Abnormality of the 4th metacarpal (HP:0010012)2.22714937
47Lip pit (HP:0100267)2.22518273
48Flat acetabular roof (HP:0003180)2.22484943
49Obstructive sleep apnea (HP:0002870)2.21023750
50Renal duplication (HP:0000075)2.20849296
51Inflammation of the large intestine (HP:0002037)2.20722281
52Hyperkalemia (HP:0002153)2.19371506
53Dysmetric saccades (HP:0000641)2.19175267
54Abnormality of the radial head (HP:0003995)2.17599544
55Colon cancer (HP:0003003)2.17543297
56Birth length less than 3rd percentile (HP:0003561)2.15357108
57Prominent nose (HP:0000448)2.15184726
58Broad distal phalanx of finger (HP:0009836)2.15145984
59Rhizomelia (HP:0008905)2.15094409
60Selective tooth agenesis (HP:0001592)2.14801152
61Flattened epiphyses (HP:0003071)2.14199753
62Abnormal large intestine physiology (HP:0012700)2.13660514
63Trigonocephaly (HP:0000243)2.11345276
64Agammaglobulinemia (HP:0004432)2.10891273
65Ectopic kidney (HP:0000086)2.10506963
66Hypochromic microcytic anemia (HP:0004840)2.09849402
67Cerebral aneurysm (HP:0004944)2.09612226
68Intrahepatic cholestasis (HP:0001406)2.08743747
69Proximal placement of thumb (HP:0009623)2.08647097
70Shawl scrotum (HP:0000049)2.06179327
71Abnormality of monocarboxylic acid metabolism (HP:0010996)2.05829216
72Complement deficiency (HP:0004431)2.05271602
73Sandal gap (HP:0001852)2.05083965
74Abnormality of the lower motor neuron (HP:0002366)2.05027195
75Abnormality of pyrimidine metabolism (HP:0004353)2.04290178
76Osteomalacia (HP:0002749)2.03819641
77Chromsome breakage (HP:0040012)2.03776251
78Large hands (HP:0001176)2.03321857
79Papillary thyroid carcinoma (HP:0002895)2.03272481
80Skull defect (HP:0001362)2.03126031
81Germ cell neoplasia (HP:0100728)2.02743696
82Elfin facies (HP:0004428)2.02236908
83Cutis marmorata (HP:0000965)2.01838821
84Deviation of the thumb (HP:0009603)2.00103583
85Cellulitis (HP:0100658)1.99879833
86Abnormal number of incisors (HP:0011064)1.99257308
87Carpal bone hypoplasia (HP:0001498)1.98391445
88Spastic diplegia (HP:0001264)1.97521088
89Abnormality of chromosome segregation (HP:0002916)1.95765569
90Cafe-au-lait spot (HP:0000957)1.95764751
91Short 5th finger (HP:0009237)1.94945661
92Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.94579859
93Abnormality of the thoracic spine (HP:0100711)1.94521898
94Abnormality of cochlea (HP:0000375)1.93744484
95Fatigue (HP:0012378)1.92796224
96Basal cell carcinoma (HP:0002671)1.92515946
97Posterior subcapsular cataract (HP:0007787)1.91754944
98Joint hemorrhage (HP:0005261)1.89863935
99Atelectasis (HP:0100750)1.89606384
100Glioma (HP:0009733)1.88498136
101Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.87669064
102Abnormality of sulfur amino acid metabolism (HP:0004339)1.87152207
103Upper motor neuron abnormality (HP:0002127)1.86647315
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.85681370
105Vitreoretinal degeneration (HP:0000655)1.84176363
106Broad face (HP:0000283)1.84146809
107Truncus arteriosus (HP:0001660)1.84134595
108J-shaped sella turcica (HP:0002680)1.83618353
109Impulsivity (HP:0100710)1.83198069
110Broad palm (HP:0001169)1.83100447
111Metaphyseal cupping (HP:0003021)1.83068909
112Eczematoid dermatitis (HP:0000976)1.83018597
113High pitched voice (HP:0001620)1.82735255
114Cortical dysplasia (HP:0002539)1.82446702
115High anterior hairline (HP:0009890)1.81973876
116Deep philtrum (HP:0002002)1.81282741
117Abnormality of reticulocytes (HP:0004312)1.80840496
118Oligodactyly (HP:0012165)1.79768688
119Pigmentary retinal degeneration (HP:0001146)1.77539163
120Leiomyosarcoma (HP:0100243)1.76995156
121Uterine leiomyosarcoma (HP:0002891)1.76995156
122Prolonged partial thromboplastin time (HP:0003645)1.76920664
123Ankle clonus (HP:0011448)1.76891392
124Increased IgE level (HP:0003212)1.76702403
125Facial hemangioma (HP:0000329)1.76519193
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76268739
127Deep palmar crease (HP:0006191)1.76125432
128Recurrent gram-negative bacterial infections (HP:0005420)1.75171112
129Peripheral hypomyelination (HP:0007182)1.75058421
130Seborrheic dermatitis (HP:0001051)1.74836083
131Broad thumb (HP:0011304)1.74474799
132Thin ribs (HP:0000883)1.74104392
133Amaurosis fugax (HP:0100576)1.73751282
134Synophrys (HP:0000664)1.73720750
135Microvesicular hepatic steatosis (HP:0001414)1.73433799
136Abnormality of lateral ventricle (HP:0030047)1.73389747
137Rimmed vacuoles (HP:0003805)1.73360813
138Menstrual irregularities (HP:0000858)1.72789849
139Limited elbow extension (HP:0001377)1.71878002
140Asymmetry of the thorax (HP:0001555)1.71227603
141Abnormality of complement system (HP:0005339)1.71226713
142Overlapping toe (HP:0001845)1.70642853
143Hemangiomatosis (HP:0007461)1.69669455
144Neuronal loss in central nervous system (HP:0002529)1.69584078
145Visceral angiomatosis (HP:0100761)1.69430832
146Skin tags (HP:0010609)1.69135699
147Ulnar bowing (HP:0003031)1.68928571
148Thin bony cortex (HP:0002753)1.68398792
149Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68155632
150Asymmetric growth (HP:0100555)1.67418274
151Slow saccadic eye movements (HP:0000514)1.66831144
152Biliary tract neoplasm (HP:0100574)1.66702928
153Gingivitis (HP:0000230)1.66654342
154Vertebral arch anomaly (HP:0008438)1.66619965
155Abnormality of the periventricular white matter (HP:0002518)1.66022221
156Abnormality of chromosome stability (HP:0003220)1.65760082
157Papilledema (HP:0001085)1.64952020
158Bony spicule pigmentary retinopathy (HP:0007737)1.64494103
159Abnormality of oral frenula (HP:0000190)1.63905623
160Thoracic kyphosis (HP:0002942)1.63749852
161Obsessive-compulsive behavior (HP:0000722)1.63587280
162Bell-shaped thorax (HP:0001591)1.63487407
163Centrally nucleated skeletal muscle fibers (HP:0003687)1.63087855
164Rectal prolapse (HP:0002035)1.62706855
165Oligodactyly (hands) (HP:0001180)1.62260322
166Acute hepatic failure (HP:0006554)1.61719750
167Gonadotropin excess (HP:0000837)1.61432440
168Abdominal distention (HP:0003270)1.61417736
169Bicuspid aortic valve (HP:0001647)1.60768178
170Urethral obstruction (HP:0000796)1.60192535
171Absent radius (HP:0003974)1.60173297
172Abnormality of the salivary glands (HP:0010286)1.60036528
173Abnormality of the lumbar spine (HP:0100712)1.60026367
174Overriding aorta (HP:0002623)1.59328296
175Acanthocytosis (HP:0001927)1.59317150
176Gastrointestinal stroma tumor (HP:0100723)1.59105741
177Spina bifida occulta (HP:0003298)1.58032976
178Abnormality of the labia minora (HP:0012880)1.57970835
179Broad phalanges of the hand (HP:0009768)1.57390532
180Aplasia involving forearm bones (HP:0009822)1.56792543
181Absent forearm bone (HP:0003953)1.56792543
182Myelodysplasia (HP:0002863)1.56288461
183Aortic aneurysm (HP:0004942)1.55888867
184Depressed nasal tip (HP:0000437)1.55687054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.37393910
2EEF2K4.01688423
3CDK123.75464450
4MAP3K103.24944865
5NEK22.99169930
6CDC72.93543709
7MET2.91032000
8PRPF4B2.80160182
9BRD42.41844889
10TTK2.37902933
11LATS12.27283739
12BMX2.22260301
13BUB12.20251745
14CSF1R2.05602662
15RET2.01385173
16FGR1.91260251
17TRIB31.90769859
18PKN21.89959404
19ERN11.89138066
20STK101.75347006
21RPS6KB21.73434590
22MAP3K21.70016660
23CDK41.68397428
24RIPK41.67144946
25SRPK11.66491359
26WEE11.63037151
27ACVR1B1.51083716
28STK31.45096461
29PTK2B1.44322637
30MELK1.43992816
31ICK1.42632472
32FGFR41.42076368
33SMG11.37038699
34SIK11.36063518
35EPHA31.34916929
36MAP4K11.32002728
37RIPK11.31423988
38ATR1.30417874
39MTOR1.30159129
40NEK11.29328461
41PLK11.28511831
42PDGFRB1.23117688
43TAOK31.23091734
44CHEK11.20905735
45TNK21.18849209
46PTK61.18665904
47MARK21.17222568
48CDK71.16791013
49CDK91.15265412
50CHEK21.13592007
51CDK61.08605047
52MAP3K61.07345418
53MAP3K81.04846766
54NEK61.04534436
55MAPKAPK31.02357790
56CAMK1D1.02199287
57NTRK31.00621742
58AURKB1.00352262
59FGFR20.97553939
60MAP3K130.97352199
61PDPK10.93786834
62PLK40.91522538
63WNK10.90429091
64FGFR30.90327709
65PDK10.90007037
66BCKDK0.88769290
67MAP2K20.88713952
68PASK0.88271264
69DYRK30.87770189
70YES10.86926413
71STK40.86702026
72TYRO30.85570778
73JAK30.85480553
74CDK20.85411766
75STK38L0.85132774
76CAMKK10.84327896
77CAMK1G0.84039584
78KSR20.83158877
79LRRK20.82815124
80CDC42BPA0.82664900
81ATM0.82216998
82MAPK110.81230136
83GRK60.79819381
84TGFBR10.77378237
85MAPK120.76786795
86FLT30.74981208
87TAOK10.74851766
88MST1R0.73129986
89ERBB20.72847021
90BRSK10.72704761
91BTK0.72103075
92FGFR10.71468083
93MAP3K70.71155677
94LATS20.70966693
95CDK190.69599898
96RAF10.69508967
97BLK0.68101931
98JAK20.67376323
99MAP3K140.66908424
100ZAP700.66731243
101MAP3K10.65956235
102ALK0.64886331
103CDK10.64790782
104SGK10.64780855
105MAPK70.64573915
106PDGFRA0.64458602
107BRSK20.62675753
108CHUK0.60181067
109RPS6KA40.60050417
110PAK40.58111617
111MAPK100.57452321
112TYK20.57055773
113DMPK0.55855575
114PLK30.55191555
115SGK20.54425488
116HIPK20.53453145
117MARK30.52946937
118NUAK10.52617936
119JAK10.52273117
120PRKD20.52245585
121RPS6KB10.51746327
122KSR10.51195817
123NEK90.51104079
124PIM10.49673545
125PRKAA20.48244976
126CCNB10.46906556
127PRKAA10.46631803
128HCK0.46584950
129TTN0.46018517
130MAP2K30.45654597
131EPHA20.44509866
132UHMK10.43952934
133MAPK150.43894464
134SYK0.43703987
135MAPK10.43578556
136MAPK140.43544846
137SIK20.43368451
138MAP3K90.42600215
139TSSK60.41792200
140MAP2K60.41493262
141MAPK30.41385339
142SGK30.40569554
143SIK30.39763832
144PRKD30.39728291
145SGK4940.38949527
146SGK2230.38949527
147GSK3B0.38699666
148ITK0.38363378
149CSNK1D0.37962650
150CDK30.37578920
151NLK0.37310772
152DYRK1B0.36874478
153PTK20.36609710
154PRKDC0.36086101
155RPS6KA10.35286863
156CDK80.33453704
157STK110.33100503

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.61028024
2DNA replication_Homo sapiens_hsa030302.56295624
3Cell cycle_Homo sapiens_hsa041102.52289294
4Lysine degradation_Homo sapiens_hsa003102.44898613
5One carbon pool by folate_Homo sapiens_hsa006702.33022635
6RNA transport_Homo sapiens_hsa030132.20939044
7Mismatch repair_Homo sapiens_hsa034302.18319580
8Base excision repair_Homo sapiens_hsa034102.17979901
9mRNA surveillance pathway_Homo sapiens_hsa030152.09360969
10Selenocompound metabolism_Homo sapiens_hsa004502.04169438
11VEGF signaling pathway_Homo sapiens_hsa043701.88970755
12Spliceosome_Homo sapiens_hsa030401.85340518
13Choline metabolism in cancer_Homo sapiens_hsa052311.80155948
14Non-homologous end-joining_Homo sapiens_hsa034501.76441565
15Notch signaling pathway_Homo sapiens_hsa043301.73031408
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.72891904
17ErbB signaling pathway_Homo sapiens_hsa040121.72519764
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66556945
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66195341
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.60218490
21Arginine biosynthesis_Homo sapiens_hsa002201.55426224
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54382912
23Inositol phosphate metabolism_Homo sapiens_hsa005621.54227919
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52096338
25Biosynthesis of amino acids_Homo sapiens_hsa012301.51299435
26Nitrogen metabolism_Homo sapiens_hsa009101.48906075
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46138172
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45885117
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45691055
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44493902
31Homologous recombination_Homo sapiens_hsa034401.41786491
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38000337
33* RNA degradation_Homo sapiens_hsa030181.32033903
34Insulin signaling pathway_Homo sapiens_hsa049101.26868713
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.26399902
36Renal cell carcinoma_Homo sapiens_hsa052111.24063041
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.23305214
38Nucleotide excision repair_Homo sapiens_hsa034201.22232937
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21891610
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20837873
41p53 signaling pathway_Homo sapiens_hsa041151.18476005
42Basal transcription factors_Homo sapiens_hsa030221.17952424
43Prolactin signaling pathway_Homo sapiens_hsa049171.17542044
44Fanconi anemia pathway_Homo sapiens_hsa034601.17234135
45Estrogen signaling pathway_Homo sapiens_hsa049151.16721239
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14518974
47Adipocytokine signaling pathway_Homo sapiens_hsa049201.13762357
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12388047
49Glioma_Homo sapiens_hsa052141.11415366
50Fatty acid degradation_Homo sapiens_hsa000711.09936438
51MicroRNAs in cancer_Homo sapiens_hsa052061.09839395
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09590636
53T cell receptor signaling pathway_Homo sapiens_hsa046601.09577412
54GnRH signaling pathway_Homo sapiens_hsa049121.08521808
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.07478237
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.07356347
57Chronic myeloid leukemia_Homo sapiens_hsa052201.06733088
58Prion diseases_Homo sapiens_hsa050201.04943462
59mTOR signaling pathway_Homo sapiens_hsa041501.04933683
60Basal cell carcinoma_Homo sapiens_hsa052171.03534903
61Small cell lung cancer_Homo sapiens_hsa052221.01894405
62Type II diabetes mellitus_Homo sapiens_hsa049301.01250957
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01017091
64Phenylalanine metabolism_Homo sapiens_hsa003601.00476928
65Tryptophan metabolism_Homo sapiens_hsa003801.00054459
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.99478456
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.99134645
68Oocyte meiosis_Homo sapiens_hsa041140.93948242
69HTLV-I infection_Homo sapiens_hsa051660.93868782
70Pancreatic cancer_Homo sapiens_hsa052120.93162546
71Fat digestion and absorption_Homo sapiens_hsa049750.92762784
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91171523
73Influenza A_Homo sapiens_hsa051640.91107640
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90899666
75Colorectal cancer_Homo sapiens_hsa052100.90726348
76Osteoclast differentiation_Homo sapiens_hsa043800.89404065
77Herpes simplex infection_Homo sapiens_hsa051680.89095628
78Adherens junction_Homo sapiens_hsa045200.87228351
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86934656
80Hippo signaling pathway_Homo sapiens_hsa043900.86305839
81Complement and coagulation cascades_Homo sapiens_hsa046100.84973961
82Vitamin B6 metabolism_Homo sapiens_hsa007500.84633383
83Primary immunodeficiency_Homo sapiens_hsa053400.82932792
84Pentose phosphate pathway_Homo sapiens_hsa000300.82915357
85Long-term potentiation_Homo sapiens_hsa047200.82646509
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82576772
87Insulin resistance_Homo sapiens_hsa049310.82246360
88Non-small cell lung cancer_Homo sapiens_hsa052230.80797647
89Carbon metabolism_Homo sapiens_hsa012000.79827477
90N-Glycan biosynthesis_Homo sapiens_hsa005100.78162452
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.77507627
92Hepatitis C_Homo sapiens_hsa051600.77489297
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.77229559
94Fructose and mannose metabolism_Homo sapiens_hsa000510.76673329
95Viral carcinogenesis_Homo sapiens_hsa052030.76489455
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76156136
97Leishmaniasis_Homo sapiens_hsa051400.76087761
98Endometrial cancer_Homo sapiens_hsa052130.75835094
99Folate biosynthesis_Homo sapiens_hsa007900.75504677
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72768850
101ABC transporters_Homo sapiens_hsa020100.72643786
102Staphylococcus aureus infection_Homo sapiens_hsa051500.72111843
103Pyrimidine metabolism_Homo sapiens_hsa002400.71823844
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69696671
105Fatty acid biosynthesis_Homo sapiens_hsa000610.69496898
106HIF-1 signaling pathway_Homo sapiens_hsa040660.69329645
107Toxoplasmosis_Homo sapiens_hsa051450.66850753
108Measles_Homo sapiens_hsa051620.66726915
109Fatty acid metabolism_Homo sapiens_hsa012120.66669365
110Epstein-Barr virus infection_Homo sapiens_hsa051690.66610372
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66591173
112AMPK signaling pathway_Homo sapiens_hsa041520.65018584
113B cell receptor signaling pathway_Homo sapiens_hsa046620.64685378
114RNA polymerase_Homo sapiens_hsa030200.64310339
115TGF-beta signaling pathway_Homo sapiens_hsa043500.63667846
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62636293
117Dorso-ventral axis formation_Homo sapiens_hsa043200.62350827
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62094913
119Propanoate metabolism_Homo sapiens_hsa006400.62077489
120Bladder cancer_Homo sapiens_hsa052190.60938329
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60678815
122Bile secretion_Homo sapiens_hsa049760.59913825
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59546683
124PPAR signaling pathway_Homo sapiens_hsa033200.59514536
125Acute myeloid leukemia_Homo sapiens_hsa052210.58571622
126Caffeine metabolism_Homo sapiens_hsa002320.57136439
127FoxO signaling pathway_Homo sapiens_hsa040680.55686703
128Regulation of autophagy_Homo sapiens_hsa041400.55609368
129Thyroid cancer_Homo sapiens_hsa052160.55241491
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.55226075
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53824726
132MAPK signaling pathway_Homo sapiens_hsa040100.53100669
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.53077037
134Glycerolipid metabolism_Homo sapiens_hsa005610.52262675
135Leukocyte transendothelial migration_Homo sapiens_hsa046700.51492786
136Hedgehog signaling pathway_Homo sapiens_hsa043400.51326548
137Thyroid hormone synthesis_Homo sapiens_hsa049180.51213864
138Histidine metabolism_Homo sapiens_hsa003400.50661317
139Prostate cancer_Homo sapiens_hsa052150.50485370
140Chemokine signaling pathway_Homo sapiens_hsa040620.50127910
141Circadian rhythm_Homo sapiens_hsa047100.50102914
142Pyruvate metabolism_Homo sapiens_hsa006200.50001849
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49158865
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48111830
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.47915383
146Retinol metabolism_Homo sapiens_hsa008300.47884508
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45145763
148Platelet activation_Homo sapiens_hsa046110.45024550
149Amoebiasis_Homo sapiens_hsa051460.44909217
150Hepatitis B_Homo sapiens_hsa051610.44825552
151Antigen processing and presentation_Homo sapiens_hsa046120.42301354
152Glucagon signaling pathway_Homo sapiens_hsa049220.42010650
153Proteoglycans in cancer_Homo sapiens_hsa052050.39961467
154Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39768891
155Apoptosis_Homo sapiens_hsa042100.39558402

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »